Iridocyclitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IRD001 MIFTS: 45	Iridocyclitis Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Iridocyclitis

MalaCards integrated aliases for Iridocyclitis:

Name: Iridocyclitis ¹² ⁷⁷ ⁵⁶ ⁴⁵ ¹⁵ ⁷⁴

Primary Iridocyclitis ¹² ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of sclera, cornea, iris and ciliary body

Disorders of iris and ciliary body in diseases classified elsewhere

Iridocyclitis in other diseases classified elsewhere

Iridocyclitis

Iridocyclitis, unspecified

External Ids:

Disease Ontology ¹² DOID:9383

ICD9CM ³⁶ 364.01 364.2

MeSH ⁴⁵ D015863

SNOMED-CT ⁶⁹ 12630008

ICD10 ³⁴ H20 H20.01 H20.9 more

UMLS ⁷⁴ C0007832 C0022073 C0154909

Sources

Summaries for Iridocyclitis

MalaCards based summary : Iridocyclitis, also known as primary iridocyclitis, is related to fuchs' heterochromic uveitis and anterior uveitis. An important gene associated with Iridocyclitis is DEK (DEK Proto-Oncogene), and among its related pathways/superpathways are Interferon gamma signaling and Immune response Role of DAP12 receptors in NK cells. The drugs Adalimumab and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁷ Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Sources

Related Diseases for Iridocyclitis

Diseases related to Iridocyclitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)

#	Related Disease	Score	Top Affiliating Genes
1	fuchs' heterochromic uveitis	33.8	CYP11B1 MRAP
2	anterior uveitis	32.7	HLA-A HLA-B
3	juvenile rheumatoid arthritis	30.3	DEK HLA-DPB1
4	vogt-koyanagi-harada disease	30.2	HLA-A HLA-B
5	iritis	30.1	HLA-B MRAP
6	pars planitis	30.1	HLA-A HLA-B
7	cytomegalovirus retinitis	29.7	HLA-A HLA-B
8	rubella	29.7	HLA-A HLA-B HLA-DPB1
9	herpes zoster	29.6	HLA-A HLA-B
10	spondyloarthropathy 1	29.6	HLA-B MRAP
11	glaucomatocyclitic crisis	29.0	CYP11B1 HLA-A HLA-B HLA-DPB1 MRAP
12	lens-induced iridocyclitis	12.3
13	gonococcal iridocyclitis	12.1
14	infectious anterior uveitis	11.7
15	phacoanaphylactic uveitis	11.6
16	retinal vasculitis	11.2
17	uveitis	10.8
18	idiopathic anterior uveitis	10.6
19	arthritis	10.6
20	rheumatoid arthritis	10.5
21	cataract	10.4
22	herpes simplex	10.2
23	diffuse infiltrative lymphocytosis syndrome	10.2	MRAP TNFRSF10B
24	chikungunya	10.1
25	hypopyon	10.1
26	toxoplasmosis	10.1
27	phenytoin or carbamazepine toxicity	10.1	HLA-A HLA-B
28	postherpetic neuralgia	10.1	HLA-A HLA-B
29	atrial tachyarrhythmia with short pr interval	10.1	HLA-A HLA-B
30	htlv-1 associated myelopathy/tropical spastic paraparesis	10.1	HLA-A HLA-B
31	pityriasis rosea	10.1	HLA-A HLA-B
32	chronic pyelonephritis	10.1	HLA-A HLA-B
33	uveal disease	10.0	HLA-B MRAP
34	human herpesvirus 8	10.0	HLA-A HLA-B
35	nontuberculous mycobacterial lung disease	10.0	HLA-A HLA-B
36	idiopathic bronchiectasis	10.0	HLA-A HLA-B
37	histoplasmosis	10.0	HLA-A HLA-B
38	retinitis	10.0
39	syphilis	10.0
40	conjunctivitis	10.0
41	psoriasis	10.0
42	ocular toxoplasmosis	10.0
43	alveolar echinococcosis	10.0	HLA-A HLA-B
44	hematopoietic stem cell transplantation	10.0	HLA-A HLA-B
45	separation anxiety disorder	10.0	HLA-A HLA-B
46	stevens-johnson syndrome/toxic epidermal necrolysis	10.0	HLA-A HLA-B
47	aphthous stomatitis	10.0	HLA-A HLA-B
48	spondyloarthropathy	10.0	HLA-A HLA-B
49	paraneoplastic pemphigus	10.0	HLA-A HLA-B
50	astigmatism	9.9

Graphical network of the top 20 diseases related to Iridocyclitis:

Sources

Symptoms & Phenotypes for Iridocyclitis

GenomeRNAi Phenotypes related to Iridocyclitis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-103	9.58	HLA-A HLA-B
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	9.58	HLA-A HLA-B
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	9.58	HLA-A HLA-B
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-156	9.58	HLA-A HLA-B
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	9.58	HLA-A HLA-B
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.58	HLA-A HLA-B
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-31	9.58	HLA-A HLA-B
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	9.58	HLA-A HLA-B
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.58	HLA-A HLA-B

Sources

Drugs & Therapeutics for Iridocyclitis

Drugs for Iridocyclitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Adalimumab

Approved

Phase 4,Phase 3

331731-18-1

16219006

Ganciclovir

Approved, Investigational

Phase 4,Phase 2,Phase 3,Not Applicable

82410-32-0

3454

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2921-57-5

Acyclovir

Approved

Phase 4,Phase 3

59277-89-3

2022

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-24-8

5755

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83-43-2

6741

leucovorin

Approved

Phase 4,Phase 1,Not Applicable

58-05-9

143 6006

Methotrexate

Approved

Phase 4,Not Applicable

1959-05-2, 59-05-2

126941

Dinoprost tromethamine

Approved, Vet_approved

Phase 4

38562-01-5

5282415

Dinoprost

Approved, Investigational

Phase 4

551-11-1

5283078

Bimatoprost

Approved, Investigational

Phase 4

155206-00-1

5311027

Difluprednate

Approved

Phase 4,Phase 3,Phase 2

23674-86-4

443936

Certolizumab pegol

Approved

Phase 4,Phase 3

428863-50-7

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 1,Not Applicable

59-30-3

6037

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2920-86-7

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antirheumatic Agents

Phase 4,Phase 3,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Ganciclovir triphosphate

Phase 4,Phase 2,Phase 3,Not Applicable

Antiviral Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Methylprednisolone Acetate

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Prednisolone acetate

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antimetabolites, Antineoplastic

Phase 4,Not Applicable

Folate

Phase 4,Phase 1,Not Applicable

Vitamin B9

Phase 4,Phase 1,Not Applicable

Vitamin B Complex

Phase 4,Phase 1,Not Applicable

Folic Acid Antagonists

Phase 4,Phase 1,Not Applicable

Dermatologic Agents

Phase 4,Phase 3,Not Applicable

Antimetabolites

Phase 4,Not Applicable

Melanocyte-Stimulating Hormones

Phase 4,Not Applicable

beta-endorphin

Phase 4,Not Applicable

Adrenocorticotropic Hormone

Phase 4,Not Applicable

Oxytocics

Phase 4

Benzalkonium Compounds

Phase 4,Phase 3

Ophthalmic Solutions

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Lubricant Eye Drops

Phase 4

Antihypertensive Agents

Phase 4

Anti-Infective Agents, Local

Phase 4,Phase 3

Pharmaceutical Solutions

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

valacyclovir

Phase 4

Ranibizumab

Approved

Phase 2, Phase 3

347396-82-1

459903

Etanercept

Approved, Investigational

Phase 3,Not Applicable

185243-69-0

Fluprednisolone

Approved

Phase 3,Phase 2

53-34-9

Interventional clinical trials:

(show top 50) (show all 69)

#	Name	Status	NCT ID	Phase	Drugs
1	Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients	Completed	NCT02764697	Phase 4	H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2	Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)	Completed	NCT02059655	Phase 4	Bimatoprost;Eye drop solution
3	A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment	Completed	NCT02897115	Phase 4
4	Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis	Recruiting	NCT02943057	Phase 4	2% guttae ganciclovir
5	A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU	Active, not recruiting	NCT03020992	Phase 4	Certolizumab Pegol
6	Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis	Not yet recruiting	NCT03626376	Phase 4	oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
7	Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis	Terminated	NCT02769702	Phase 4	Acthar
8	Methotrexate in the Treatment of Axial Spondyloarthritis	Withdrawn	NCT00298012	Phase 4	Methotrexate
9	Herpetic Eye Disease Study (HEDS) I	Unknown status	NCT00000138	Phase 3	Prednisolone Phosphate;Acyclovir
10	Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy	Unknown status	NCT02769169	Phase 2, Phase 3	Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
11	Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis	Completed	NCT01201798	Phase 3	Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
12	A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis	Completed	NCT00404885	Phase 3	Placebo;LX211;LX211;LX211
13	Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis	Completed	NCT02517619	Phase 3	Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
14	Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis	Completed	NCT00406887	Phase 3	Difluprednate Ophthalmic Emulsion
15	Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis	Completed	NCT01505088	Phase 3	40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
16	Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis	Completed	NCT00407056	Phase 3	Difluprednate Ophthalmic Emulsion
17	Herpetic Eye Disease Study (HEDS) II	Completed	NCT00000139	Phase 3	Acyclovir
18	Study of Difluprednate in the Treatment of Uveitis	Completed	NCT00501579	Phase 3	Difluprednate;Prednisolone Acetate
19	CLARITY Extension Study	Completed	NCT00641537	Phase 3	Cladribine;Placebo;Cladribine;Cladribine;Placebo
20	Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis	Completed	NCT03097315	Phase 3
21	Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis	Completed	NCT02595398	Phase 3	4mg CLS-TA Suprachoriodal Injection;Sham Procedure
22	A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis	Completed	NCT02696785	Phase 3	Ixekizumab;Placebo;Adalimumab
23	SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis.	Recruiting	NCT03131154	Phase 3	ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
24	Treatment Tapering in JIA With Inactive Disease	Recruiting	NCT02840175	Phase 3	etanercept;adalimumab;Abatacept;Tocilizumab
25	A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis	Active, not recruiting	NCT03129100	Phase 3	Ixekizumab;Placebo
26	Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS	Active, not recruiting	NCT02552212	Phase 3
27	A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis	Active, not recruiting	NCT02757352	Phase 3	Ixekizumab;Placebo
28	A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis	Active, not recruiting	NCT02696798	Phase 3	Ixekizumab;Placebo
29	Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes	Not yet recruiting	NCT03586284	Phase 2, Phase 3	Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
30	Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis	Not yet recruiting	NCT03576898	Phase 2, Phase 3	Topical ganciclovir versus oral valganciclovir versus placebo
31	Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)	Not yet recruiting	NCT03841357	Phase 3	Abatacept Injection
32	A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis	Terminated	NCT00333996	Phase 2, Phase 3	Dexamethasone
33	Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis	Completed	NCT02482129	Phase 2	LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
34	A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis	Completed	NCT02406209	Phase 2	NS2;Prednisolone acetate ophthalmic suspension (1%)
35	Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis	Completed	NCT02309385	Phase 1, Phase 2	8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
36	Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis	Completed	NCT00823173	Phase 2
37	Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis	Completed	NCT00405496	Phase 2	Difluprednate Ophthalmic Emulsion
38	Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis	Completed	NCT00130637	Phase 2	Daclizumab
39	Topical Interferon Gamma for Macular Edema Secondary to Uveitis	Completed	NCT01376362	Phase 1, Phase 2	Interferon Gamma-1b
40	Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis	Completed	NCT00694135	Phase 2	EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
41	Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis	Completed	NCT02255032	Phase 2	4 mg CLS-TA;0.8 mg CLS-TA
42	Safety and Efficacy of AIN457 in Noninfectious Uveitis	Completed	NCT00685399	Phase 2	AIN457;AIN 457;AIN457
43	A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis	Withdrawn	NCT00499551	Phase 1, Phase 2
44	Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti	Completed	NCT00876434	Phase 1	Sirolimus
45	Study to Evaluate GSK3052230 in Combination With Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects With Solid Malignancies and Deregulated Fibroblast Growth Factor (FGF) Pathway Signaling	Completed	NCT01868022	Phase 1	GSK3052230;paclitaxel;carboplatin;docetaxel;pemetrexed;cisplatin
46	Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions	Withdrawn	NCT02042027	Phase 1	Gamunex-C
47	Acute Anterior Uveitis: Psychic Burden and Pain	Unknown status	NCT01156285
48	Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis	Unknown status	NCT01486693
49	Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis	Unknown status	NCT02879084
50	Quality of Life and Visual Function in Uveitis Patients	Unknown status	NCT00407316

Search NIH Clinical Center for Iridocyclitis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

scopolamine

scopolamine hydrobromide

tropicamide

Cochrane evidence based reviews: iridocyclitis

Sources

Genetic Tests for Iridocyclitis

Sources

Anatomical Context for Iridocyclitis

MalaCards organs/tissues related to Iridocyclitis:

⁴²

Eye, Retina, Endothelial, Thyroid, Testes, Skin, Liver

Sources

Publications for Iridocyclitis

Articles related to Iridocyclitis:

(show top 50) (show all 288)

#	Title	Authors	Year
1	Intraocular Lymphoma Masquerading as Recurrent Iridocyclitis: Findings Based on in vivo Confocal Microscopy. ( 29099641 )	Zhang P...Gao L	2018
2	Fever of unknown origin, bilateral sensorineural hearing loss with canal paresis and uveitis with iridocyclitis and episcleritis: a case of Cogan's syndrome. ( 29703835 )	Watari T...Tokuda Y	2018
3	Fuchs heterochromic iridocyclitis-associated glaucoma: a retrospective comparison of primary Ahmed glaucoma valve implantation and trabeculectomy with mitomycin C. ( 30410728 )	Esfandiari H...Pakravan M	2018
4	Moth-eaten appearance of the iris in Fuchs heterochromic iridocyclitis. ( 30447956 )	Kouisbahi A...Berraho A	2018
5	Anti-dense Fine Speckled 70 Autoantibodies in Japanese Children with Dermatomyositis, Localized Scleroderma, and Idiopathic Arthritis with Iridocyclitis. ( 28461535 )	Muro Y...Akiyama M	2017
6	Risk Factors for Glaucoma in a Cohort of Patients with Fuchs Heterochromic Iridocyclitis. ( 27494676 )	Toniolo JT...Lim LL	2017
7	The unusual association of inverse retinitis pigmentosa and Fuchs' heterochromic iridocyclitis. ( 28127443 )	D?ez-Cattini GF...Morales-Cant?n V	2017
8	Leprosy Presenting with Iridocyclitis: A Diagnostic Dilemma. ( 29090057 )	Kaushik J...Agarwal S	2017
9	Niemann-Pick Disease Type C Associated with Fuchs Heterochromic Iridocyclitis. ( 29387679 )	Kianersi F...Sonbolestan SA	2017
10	Phacoemulsification Versus Manual Small Incision Cataract Surgery in Patients With Fuchs Heterochromic Iridocyclitis. ( 26939115 )	Bhargava R...Arora Y	2016
11	Zika virus-related hypertensive iridocyclitis. ( 26840174 )	Fontes BM	2016
12	Syphilis iridocyclitis in a patient with type 1 diabetes. ( 27180731 )	Comassi M...Solini A	2016
13	Fuchs' Heterochromic Iridocyclitis in an Italian Tertiary Referral Centre: Epidemiology, Clinical Features, and Prognosis. ( 27781126 )	Accorinti M...Iannetti L	2016
14	Recurrent iridocyclitis due to cotton fiber in anterior chamber. ( 28242892 )	Joshi RS	2016
15	Polymorphisms in cytomegalovirus genotype in immunocompetent patients with corneal endotheliitis or iridocyclitis. ( 25963863 )	Oka N...Ohashi Y	2015
16	Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses. ( 25399915 )	Pinto NI...Gilger BC	2015
17	Acute granulomatous iridocyclitis in a child with tubulointerstitial nephritis and uveitis syndrome. ( 25861394 )	Barut K...Kasapcopur O	2015
18	Bilateral acute iris transillumination (BAIT) initially misdiagnosed as acute iridocyclitis. ( 25945534 )	Gonul S...Bozkurt B	2015
19	Analysis on the psychological characteristics of patients with acute iridocyclitis. ( 26086022 )	Sun W...Li XY	2015
20	Fuch's Heterochromic Iridocyclitis in Iran: Is the Disease Going to Fade Away? ( 26730326 )	Piri N...Kaplan HJ	2015
21	Hypertensive iridocyclitis associated with delayed onset biopsy proven Cytomegalovirus retinitis. ( 23548320 )	Squirrell DM...Rennie IG	2014
22	Polymorphisms of TNFAIP3 gene in a Chinese Han population with fuchs heterochromic iridocyclitis. ( 23463983 )	Li H...Liu Q	2014
23	Implantation of iris-claw Artisan intraocular lens for aphakia in Fuchs' heterochromic iridocyclitis. ( 23571252 )	Kheirkhah A...Ghadimi H	2014
24	Small-incision cataract surgery in patients with Fuch's heterochromic iridocyclitis. ( 25680261 )	Bhargava R...Godara R	2014
25	Herniation of the retina in the central macula in an adult after iridocyclitis. ( 26011975 )	Guo Q...Gao T	2014
26	Associations of Fuchs heterochromic iridocyclitis in a South Indian patient population. ( 23514352 )	Babu K...Murthy KR	2013
27	Surgical management of secondary glaucoma in Fuchs' heterochromic iridocyclitis. ( 23519886 )	You YA...Hu S	2013
28	Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. ( 22218256 )	Babu K...Murthy GJ	2012
29	Frequency of iridocyclitis in patients with early psoriatic arthritis: a prospective, follow up study. ( 22898222 )	Niccoli L...Cantini F	2012
30	Corneal astigmatism in unilateral Fuchs heterochromic iridocyclitis. ( 21595529 )	Faramarzi A...Yaseri M	2011
31	Bilateral acute depigmentation of the iris first misdiagnosed as acute iridocyclitis. ( 21633847 )	Goktas A...Goktas S	2011
32	Fuchs heterochromic iridocyclitis and the rubella virus. ( 21897135 )	Liu Y...Pasquale LR	2011
33	Adenoma of the nonpigmented ciliary epithelium presenting with recurrent iridocyclitis: unique expression of glial fibrillary acidic protein. ( 21088853 )	Bae JH...Lee SC	2011
34	Fuchs' heterochromic iridocyclitis associated with ocular toxocariasis. ( 21331701 )	Hashida N...Maruyama H	2011
35	Levocetirizine-induced iridocyclitis in a patient with allergic rhinitis. ( 20232781 )	Konstantinou GN...Ligeros MP	2010
36	Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. ( 20952847 )	Mahendradas P...Madhavan HN	2010
37	The possible role of systemic azithromycin for idiopathic iridocyclitis. ( 19891670 )	Wirostko BM...Wirostko WJ	2010
38	Confocal scan features of keratic precipitates in Fuchs heterochromic iridocyclitis. ( 19907293 )	Kanavi MR...Peyman GA	2010
39	Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis. ( 20585798 )	Suzuki J...Okamoto K	2010
40	Sarcoidosis presenting with massive splenomegaly in a child with a history of iridocyclitis and sensorineural deafness. ( 20615071 )	Alsultan A...Alsubaie S	2010
41	Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis. ( 20737053 )	Suzuki K...Nakazawa M	2010
42	Klebsiella pneumoniae endophthalmitis secondary to liver abscess presenting as acute iridocyclitis. ( 19772282 )	Dodson D...Ayyala RS	2009
43	Presumed Fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and -negative eyes. ( 19463548 )	Wong M...Tessler HH	2009
44	Retinal thickening in iridocyclitis. ( 19477710 )	Castellano CG...Jaffe GJ	2009
45	Fuchs heterochromic iridocyclitis--syndrome, disease, or both? ( 19782794 )	Cunningham ET...Baglivo E	2009
46	Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis. ( 18435976 )	Van Gelder RN	2008
47	Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. ( 19027423 )	Chee SP...Jap A	2008
48	Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis. ( 17522780 )	Kawaguchi T...Mochizuki M	2007
49	Epidemiologic relationship between fuchs heterochromic iridocyclitis and the United States rubella vaccination program. ( 17631266 )	Birnbaum AD...Goldstein DA	2007
50	Rubella virus is associated with fuchs heterochromic iridocyclitis. ( 16387009 )	de Groot-Mijnes JD...Weersink AJ	2006

Sources

Genes for Iridocyclitis

Genes related to Iridocyclitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	DEK	DEK Proto-Oncogene	Protein Coding	20.55	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9058666
2	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	19.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	17.78	DISEASES inferred ¹⁵
4	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	16.81	DISEASES inferred ¹⁵
5	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	15.46	DISEASES inferred ¹⁵
6	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	15.1	DISEASES inferred ¹⁵
7	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	Protein Coding	15.06	DISEASES inferred ¹⁵
8	WDR11	WD Repeat Domain 11	Protein Coding	14.68	DISEASES inferred ¹⁵
9	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	14.42	DISEASES inferred ¹⁵

Sources

Variations for Iridocyclitis

Sources

Expression for Iridocyclitis

Search GEO for disease gene expression data for Iridocyclitis.

Sources

Pathways for Iridocyclitis

Pathways related to Iridocyclitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Interferon gamma signaling ⁶⁷ Show member pathways Interferon Signaling ⁶⁷ Regulation of IFNG signaling ⁶⁷	12.04	HLA-A HLA-B HLA-DPB1
2	Immune response Role of DAP12 receptors in NK cells ²³ Show member pathways Immune response CD16 signaling in NK cells ²³ Natural killer cell mediated cytotoxicity ³⁸	11.97	HLA-A HLA-B TNFRSF10B
3	Human T-cell leukemia virus 1 infection ³⁸	11.77	HLA-A HLA-B HLA-DPB1
4	Phagosome ³⁸	11.31	HLA-A HLA-B HLA-DPB1
5	Cell adhesion molecules (CAMs) ³⁸	10.96	HLA-A HLA-B HLA-DPB1
6	Antigen Presentation- Folding, assembly and peptide loading of class I MHC ⁶⁷	10.55	HLA-A HLA-B

Sources

GO Terms for Iridocyclitis

Cellular components related to Iridocyclitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.56	HLA-A HLA-B HLA-DPB1 TNFRSF10B
2	recycling endosome membrane	GO:0055038	9.37	HLA-A HLA-B
3	phagocytic vesicle membrane	GO:0030670	9.32	HLA-A HLA-B
4	MHC class I protein complex	GO:0042612	9.16	HLA-A HLA-B
5	ER to Golgi transport vesicle membrane	GO:0012507	9.13	HLA-A HLA-B HLA-DPB1
6	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	8.8	HLA-A HLA-B HLA-DPB1

Biological processes related to Iridocyclitis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.67	CYP11B1 HLA-A HLA-B HLA-DPB1
2	type I interferon signaling pathway	GO:0060337	9.49	HLA-A HLA-B
3	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	9.48	TNFAIP3 TNFRSF10B
4	antigen processing and presentation of peptide antigen via MHC class I	GO:0002474	9.46	HLA-A HLA-B
5	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:0002479	9.43	HLA-A HLA-B
6	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.4	HLA-A HLA-B
7	interferon-gamma-mediated signaling pathway	GO:0060333	9.33	HLA-A HLA-B HLA-DPB1
8	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:0002480	9.32	HLA-A HLA-B
9	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	GO:0002476	9.26	HLA-A HLA-B
10	protection from natural killer cell mediated cytotoxicity	GO:0042270	8.96	HLA-A HLA-B
11	antigen processing and presentation	GO:0019882	8.8	HLA-A HLA-B HLA-DPB1

Molecular functions related to Iridocyclitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptide antigen binding	GO:0042605	8.8	HLA-A HLA-B HLA-DPB1

Sources

Sources for Iridocyclitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Iridocyclitis

Aliases & Classifications for Iridocyclitis

MalaCards integrated aliases for Iridocyclitis:

Classifications:

External Ids:

Summaries for Iridocyclitis

Related Diseases for Iridocyclitis

Diseases related to Iridocyclitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Iridocyclitis:

Symptoms & Phenotypes for Iridocyclitis

GenomeRNAi Phenotypes related to Iridocyclitis according to GeneCards Suite gene sharing:

Drugs & Therapeutics for Iridocyclitis

Drugs for Iridocyclitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: iridocyclitis

Genetic Tests for Iridocyclitis

Anatomical Context for Iridocyclitis

MalaCards organs/tissues related to Iridocyclitis:

Publications for Iridocyclitis

Articles related to Iridocyclitis:

Genes for Iridocyclitis

Genes related to Iridocyclitis (0 elite genes):

Variations for Iridocyclitis

Expression for Iridocyclitis

Pathways for Iridocyclitis

Pathways related to Iridocyclitis according to GeneCards Suite gene sharing:

GO Terms for Iridocyclitis

Cellular components related to Iridocyclitis according to GeneCards Suite gene sharing:

Biological processes related to Iridocyclitis according to GeneCards Suite gene sharing:

Molecular functions related to Iridocyclitis according to GeneCards Suite gene sharing:

Sources for Iridocyclitis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :