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MCID: IRD001
MIFTS: 53

Iridocyclitis

Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Iridocyclitis

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MalaCards integrated aliases for Iridocyclitis:

Name: Iridocyclitis 12 74 20 58 54 15 71 32
Anterior Uveitis 20 58 17
Primary Iridocyclitis 12 71

Characteristics:

Orphanet epidemiological data:

58
anterior uveitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9383
ICD9CM 34 364.01 364.2
SNOMED-CT 67 193485000 193496008
ICD10 via Orphanet 33 H20.0 H20.1 H20.2 more
UMLS via Orphanet 72 C0022073 C0042165
Orphanet 58 ORPHA280886
UMLS 71 C0007832 C0022073 C0154909
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Summaries for Iridocyclitis

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MalaCards based summary : Iridocyclitis, also known as anterior uveitis, is related to fuchs' heterochromic uveitis and systemic onset juvenile idiopathic arthritis. An important gene associated with Iridocyclitis is DEK (DEK Proto-Oncogene), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Certolizumab pegol and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

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Related Diseases for Iridocyclitis

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Diseases related to Iridocyclitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1033)
# Related Disease Score Top Affiliating Genes
1 fuchs' heterochromic uveitis 32.7 IL6 ACE
2 systemic onset juvenile idiopathic arthritis 31.8 TNF IL6
3 retinal vasculitis 31.7 TNF RBP3 CD4 ACE
4 uveoparotid fever 31.5 TNF CD8A CD4 ACE
5 blau syndrome 31.2 VEGFA TNF IL1B IL10
6 idiopathic anterior uveitis 31.1 TNF IL6
7 spondylarthropathy 30.8 TNF HLA-B
8 neuroretinitis 30.6 CRP CD4 ACE
9 back pain 30.5 IL6 IL1B
10 ocular tuberculosis 30.4 CD4 ACE
11 conjunctivitis 30.4 TNF IL6 IL10
12 panophthalmitis 30.4 CRP CD4
13 posterior uveitis 30.3 TNF RBP3 IL6
14 keratoconjunctivitis 30.3 TNF IL6 IL17A
15 pustulosis of palm and sole 30.3 TNF IL17A CRP
16 juvenile ankylosing spondylitis 30.3 TNF MRAP
17 facial hemiatrophy 30.2 MRAP CRP
18 systemic autoimmune disease 30.2 IL6 IL17A CRP
19 multifocal choroiditis 30.2 TNF IL10
20 neurosyphilis 30.2 IL17A IL10
21 uveitis 30.2 TNF RBP3 IL6 IL1B IL17A IL10
22 spotted fever rickettsiosis 30.2 TNF IL10
23 juvenile rheumatoid arthritis 30.1 TNF IL6 IL1B IL10 DEK CRP
24 drug reaction with eosinophilia and systemic symptoms 30.1 TNF HLA-B CRP
25 toxoplasmosis 30.1 TNF IL6 IL1B IL10
26 pyomyositis 30.1 CRP CD4
27 chikungunya 30.1 TNF IL6 IL1B
28 anterior scleritis 30.1 TNF CRP ACE
29 pertussis 30.1 TNF IL6 IL1B IL10
30 juvenile arthritis 30.1 IL6 IL10 DEK CRP
31 urticaria 30.1 TNF IL6 CRP
32 retinal detachment 30.1 VEGFA TNF IL6 IL10
33 asymptomatic neurosyphilis 30.1 IL17A CD4
34 pleural empyema 30.1 IL6 CRP CD4
35 secondary syphilis 30.0 CRP CD8A CD4
36 schistosomiasis 30.0 TNF IL17A IL10
37 cat-scratch disease 30.0 CRP CD4 ACE
38 spondyloarthropathy 1 30.0 TNF MRAP IL6 IL17A HLA-B CRP
39 sympathetic ophthalmia 30.0 TNF RBP3 IL10
40 papilledema 29.9 VEGFA CRP CD4 ACE
41 drug allergy 29.9 CRP CD4 ACE
42 helicobacter pylori infection 29.9 TNF IL1B IL10
43 syphilis 29.9 IL17A CRP CD8A CD4 ACE
44 intermediate uveitis 29.9 TNF IL6 IL10 HLA-B
45 blepharitis 29.9 TNF CD8A CD4
46 mumps 29.9 TNF IL6 IL1B IL10
47 enterocolitis 29.8 TNF IL6 IL10 CRP
48 vasculitis 29.8 TNF IL6 IL17A HLA-B CRP
49 vogt-koyanagi-harada disease 29.8 IL17A IL10 HLA-B CD8A
50 autoimmune uveitis 29.8 TNF RBP3 IL1B IL17A IL10

Graphical network of the top 20 diseases related to Iridocyclitis:



Diseases related to Iridocyclitis
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Symptoms & Phenotypes for Iridocyclitis

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GenomeRNAi Phenotypes related to Iridocyclitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 IL10 IL17A IL1B TNF TNFAIP3 TNFRSF10A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 ACE IL10 IL17A IL1B TNF TNFAIP3

MGI Mouse Phenotypes related to Iridocyclitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 ACE CD4 CD8A IL10 IL17A IL6
2 homeostasis/metabolism MP:0005376 10.13 ACE CD4 CRP DEK IL10 IL17A
3 hematopoietic system MP:0005397 10.11 ACE CD4 CD8A IL10 IL17A IL1B
4 immune system MP:0005387 10.03 ACE CD4 CD8A CRP IL10 IL17A
5 integument MP:0010771 9.81 CD4 CD8A IL10 IL17A IL1B IL6
6 neoplasm MP:0002006 9.56 ACE DEK IL10 IL1B IL6 TNF
7 no phenotypic analysis MP:0003012 9.17 CD4 IL10 IL17A TNF TNFAIP3 TNFRSF10A
Sources

Drugs & Therapeutics for Iridocyclitis

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Drugs for Iridocyclitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Certolizumab pegol Approved Phase 4 428863-50-7
2
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
10
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
11
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
12 Immunologic Factors Phase 4
13 Antirheumatic Agents Phase 4
14 Immunosuppressive Agents Phase 4
15 Anti-Infective Agents Phase 4
16 Antiviral Agents Phase 4
17 Ganciclovir triphosphate Phase 4
18 Protective Agents Phase 4
19 Anti-Inflammatory Agents Phase 4
20 Gastrointestinal Agents Phase 4
21 Methylprednisolone Acetate Phase 4
22 Ophthalmic Solutions Phase 4
23 Neuroprotective Agents Phase 4
24 glucocorticoids Phase 4
25 Antineoplastic Agents, Hormonal Phase 4
26 Antiemetics Phase 4
27 BB 1101 Phase 4
28 Anesthetics Phase 4
29 Hormones Phase 4
30 Hormone Antagonists Phase 4
31 Melanocyte-Stimulating Hormones Phase 4
32 Adrenocorticotropic Hormone Phase 4
33 beta-Endorphin Phase 4
34
Difluprednate Approved Phase 3 23674-86-4 443936
35
Sodium citrate Approved, Investigational Phase 3 68-04-2
36
Valganciclovir Approved, Investigational Phase 2, Phase 3 175865-60-8 64147
37
Fluorometholone Approved, Investigational Phase 3 426-13-1 9878
38
Tropicamide Approved, Investigational Phase 3 1508-75-4 5593
39
Atropine Approved, Vet_approved Phase 3 5908-99-6, 51-55-8 174174
40
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
41
Pyrazinamide Approved, Investigational Phase 3 98-96-4 1046
42
Dipivefrin Approved Phase 3 52365-63-6 3105
43
Ethambutol Approved Phase 3 74-55-5 3279 14052
44
Phenylephrine Approved Phase 3 59-42-7 6041
45
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
46
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
47
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
48 Dexamethasone 21-phosphate Phase 3
49 Citrate Phase 3
50 Anticoagulants Phase 3

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Multicenter, Open-Label Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis Flares in Axial Spondyloarthritis Subjects With a History of Anterior Uveitis (C-VIEW) Completed NCT03020992 Phase 4 Certolizumab Pegol
2 Prospective Open Label Study of H.P. Acthar Gel Injection in Patients With Active Non-Infectious Uveitis With Associated Glaucoma Thus High Frequency Regional Corticosteroid and Oral Corticosteroids Cause Intolerable Side-Effects Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
3 Intra-cameral Penetration and Efficacy of Ganciclovir Following Topical Administration of 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
4 Evaluation of DEXTENZA on the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids Not yet recruiting NCT04426734 Phase 4 Topical Prednisolone Acetate 1%
5 Prospective Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Who Are Not Well Controlled With, or Intolerant of, Topical or Systemic Corticosteroids Terminated NCT02769702 Phase 4 Acthar
6 Phase 3 Confirmatory Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Including Panuveitis). Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
7 A Prospective, Multi-Center, Randomized, Double-Masked, Positive Controlled, Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspension (1%) in Patients With Non-Infectious Anterior Segment Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
8 A Phase 3 Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
9 A Prospective, Multi-Center, Randomized, Double-Masked, Positive-Controlled Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspension (1%) in Patients With Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
10 A Phase 3, Randomized, Double-masked, Vehicle-controlled Trial to Evaluate the Safety and Efficacy of ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Completed NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
11 A Double-Masked, Placebo-Controlled, Parallel-Group, Multi-Center, Dose-Ranging Study With an Optional Extension to Assess the Efficacy and Safety of LX211 as Therapy in Subjects With Active Sight Threatening, Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
12 Phase 3 Open-Labeled Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Severe Anterior Uveitis (Including Panuveitis). Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
13 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
14 Multicenter, Randomized Study Evaluating the Value of Antitubercular Treatment During Recurent Anterior Uveitis (URBA) Not yet recruiting NCT04117698 Phase 3 Antitubercular treatment (RIFATER ©);Ethambutol;RIFINAH ©
15 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
16 A Phase 2 Randomized, Investigator-Masked, Comparator-controlled Trial to Evaluate the Safety and Efficacy of NS2 Eye Drops in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
17 A Randomized, Parallel Group, Double-masked, Active-controlled Phase 1/2 Clinical Trial to Evaluate the Efficacy and Safety of Dexamethasone Sodium Phosphate Visulex System for the Treatment of Non-infectious Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
18 A Randomized, Masked, Multicenter Study to Assess the Safety and Efficacy of CLS-TA, Triamcinolone Acetonide Injectable Suspension in the Treatment of Subjects With Macular Edema Following Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
19 Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Inluding Iritis, Cyclitis, Iridocyclitis, and Panuveitis). Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
20 The Treatment of Macular Edema Secondary to Uveitis Using Topical Interferon Gamma Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
21 Treatment of Active Anterior Uveitis Associated With JIA, Using Humanized Anti-Tac (HAT, Daclizumab) Completed NCT00130637 Phase 2 Daclizumab
22 A Multicenter, Randomized, Double-Masked, Active-Controlled Study to Evaluate the Safety and Efficacy of LME636 in Patients With Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
23 An Open Label Exploratory Study to Assess the Safety, Tolerability and Clinical Activity of Topically Applied ESBA105 in Patients With Acute Anterior Uveitis Completed NCT00823173 Phase 2
24 A Randomized, Double-Masked, Dose-Ranging Study to Evaluate the Safety and Tolerability of TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis. Completed NCT04222712 Phase 1, Phase 2 TRS01 eye drops;TRS01 eye drops
25 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveitis Completed NCT00876434 Phase 1 Sirolimus
26 Quality of Life and Visual Function in Uveitis Patients Unknown status NCT00407316
27 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
28 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
29 PEMF an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
30 Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis Completed NCT02879084
31 Efficacy and Adverse Effects of Cyclosporine A in the Treatment of Chronic Anterior Uveitis in Patients With Juvenile Idiopathic Arthritis Completed NCT00404482 Cyclosporine A
32 Intra-cameral Penetration of Ganciclovir Following Topical Administration of 0.15% Ganciclovir Gel (VIRGAN©) for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Ganciclovir
33 Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function. Completed NCT00476593 Diclofenac;Dexamethasone
34 Ocular Findings in Women With Primary Antiphospholipid Syndrome and Their Association to Bad Obstetric Outcome Completed NCT03459508
35 A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429
36 The Contribution of Altered Aqueous Dynamics in the Development of Raised Intraocular Pressure in Patients With Uveitis Completed NCT02765308
37 Evaluation and Treatment Protocol for Patients With Intraocular Inflammatory Disease (Uveitis) Completed NCT00006188
38 Ocular Sarcoidosis Open Label Trial of ACTHAR Gel Recruiting NCT02725177 Repository Corticotropin Injection;Repository Corticotropin Injection -Treatment Extension
39 Pathogen Detection in Infectious Uveitis in China Recruiting NCT04521673
40 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
41 Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis Not yet recruiting NCT04126850

Search NIH Clinical Center for Iridocyclitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Scopolamine
Scopolamine Hydrobromide
Tropicamide
Sources

Genetic Tests for Iridocyclitis

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Anatomical Context for Iridocyclitis

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MalaCards organs/tissues related to Iridocyclitis:

40
Eye, Retina, Endothelial, Neutrophil, T Cells, Bone Marrow, Lymph Node
Sources

Publications for Iridocyclitis

About this section

Articles related to Iridocyclitis:

(show top 50) (show all 4643)
# Title Authors PMID Year
1
Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. 54 61
9058666 1997
2
Epidemiology of 2000 Chinese uveitis patients from Northeast China. 61
32424058 2021
3
Epidemiology of Uveitis in a tertiary care centre in Portugal. 61
33593242 2021
4
Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a Pilot Study. 61
33593448 2021
5
Panuveitis in a patient with active Crohn's disease. 61
33541992 2021
6
Clinical Characteristics of Uveitis in Patients with Psoriasis in Korea: A Retrospective Multicenter Case Series. 61
33307622 2021
7
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis. 61
32603726 2021
8
Prognosis of Ocular Tuberculosis Following Long-Term Antitubercular Therapy. 61
33524301 2021
9
Cytomegalovirus endotheliitis with recurrent anterior uveitis and secondary glaucoma misdiagnosed as HLA-B27 uveitis. 61
33608341 2021
10
Enthesitis-related Arthritis: Prevalence and Complications of Associated Uveitis in Children and Adolescents From a Population-based Nationwide Study in Germany. 61
32173656 2021
11
5-year longitudinal study of clinical and patient-reported outcomes in acute anterior uveitis. 61
32405048 2021
12
Pyogenic granuloma after cosmetic eye whitening. 61
33158667 2021
13
Endoscopic Cyclophotocoagulation Combined with Phacoemulsification Increases Risk of Persistent Anterior Uveitis Compared to Phacoemulsification Surgery Alone. 61
33574652 2021
14
Pattern of Uveitis in Iran: A Systematic Review. 61
33520132 2021
15
Incidence of ocular inflammation among patients with active tuberculosis or nontuberculous mycobacterial infections in a tertiary hospital in Japan. 61
33475908 2021
16
Association of Anterior Uveitis With Acute Zika Virus Infection in Adults. 61
33237306 2021
17
Etiology of Uveitis in Upper Egypt. 61
33500612 2021
18
Comprehensive assessment of quality of life, functioning and mental health in children with juvenile idiopathic arthritis and non-infectious uveitis. 61
33421338 2021
19
Recommendations for the management of childhood juvenile idiopathic arthritis-type chronic anterior uveitis. 61
33426782 2021
20
Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Changes on Optical Coherence Tomography in Patients with Unilateral Hypertensive Cytomegalovirus Anterior Uveitis. 61
33460814 2021
21
Uveitis as the first symptom in spondyloarthritis and its association with the evolution of the disease. Results from the REGISPONSER registry. 61
33486107 2021
22
Zika Virus and Anterior Uveitis-4 Years After the Pandemic. 61
33237295 2021
23
Endothelin-1 Serum Concentration in Pediatric Chronic Idiopathic Uveitis. 61
33469261 2021
24
HLA-A26 is a risk factor for Behçet's disease ocular lesions. 61
31851572 2021
25
Brimonidine-associated uveitis - a descriptive case series. 61
33334316 2020
26
Acanthamoeba sclerokeratitis in a cat. 61
33269959 2020
27
Clinical course of von Szily reaction: Case report and comprehensive review of the literature. 61
33015408 2020
28
Current Approach for the Diagnosis and Management of Noninfective Scleritis. 61
33290287 2020
29
A case report of pseudo-exfoliation syndrome with prolonged corneal epithelial regeneration because of erlotinib-induced unilateral corneal ulcer and anterior uveitis. 61
32483873 2020
30
[Ocular manifestations of Crohn's disease]. 61
32950292 2020
31
Factors associated with ocular adverse event after immune checkpoint inhibitor treatment. 61
32556494 2020
32
Ocular sarcoidosis: clinical experience and recent pathogenetic and therapeutic advancements. 61
32740881 2020
33
Cataract Surgery Outcomes in Human Immunodeficiency Virus Positive Patients at a Tertiary Care Academic Medical Center in the United States. 61
33369513 2020
34
Clinical manifestations of intravitreal bortezomib injection. 61
33163689 2020
35
Belatacept associated - cytomegalovirus retinitis in a kidney transplant recipient: a case report and review of the literature. 61
33256663 2020
36
Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study. 61
31435074 2020
37
Randomized Phase 2 Trial of Reproxalap, a Novel Reactive Aldehyde Species Inhibitor, in Patients with Noninfectious Anterior Uveitis: Model for Corticosteroid Replacement. 61
32955967 2020
38
Efficacy and safety of immunomodulatory drugs in patients with non-infectious intermediate and posterior uveitis, panuveitis and macular edema: A systematic literature review. 61
33065425 2020
39
Recommendations statement on the immunosuppressive treatment of non-infectious, non-neoplastic, non-anterior uveitis. 61
33280835 2020
40
Vision loss in anterior uveitis. 61
32245851 2020
41
A white circular-spot pattern of iridian atrophy associated with Varicella-zoster virus and Toxoplasma gondii coinfection: a case report. 61
33287739 2020
42
Drug-induced ocular inflammation. 61
33332330 2020
43
Polychromasia capsulare in Fuchs heterochromic iridocyclitis: case report and literature review. 61
32822659 2020
44
Anterior chamber granuloma: conservative treatment versus surgical intervention. 61
31970931 2020
45
Heerfordt-Waldenström Syndrome. 61
33247650 2020
46
Ocular Tuberculosis in HIV-infected Individuals. 61
32809898 2020
47
Adverse Events of Intense Pulsed Light Combined With Meibomian Gland Expression Versus Meibomian Gland Expression in the Treatment of Meibomian Gland Dysfunction. 61
33161597 2020
48
Incidence of extra-articular manifestations in ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis: results from a national register-based cohort study. 61
33216939 2020
49
Title: BILATERAL UVEITIS AND HYPOTONY FOLLOWING TREATMENT WITH TOPICAL CIDOFOVIR. 61
33252508 2020
50
Clinical management of the most common extra-intestinal manifestations in patients with inflammatory bowel disease focused on the joints, skin and eyes. 61
32921269 2020
Sources

Variations for Iridocyclitis

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Expression for Iridocyclitis

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Search GEO for disease gene expression data for Iridocyclitis.
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Pathways for Iridocyclitis

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Pathways related to Iridocyclitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.02 VEGFA TNFAIP3 TNF IL6 IL1B IL17A
2
TGF-Beta Pathway 63
Show member pathways
 13.53 VEGFA TNFRSF10A TNF IL6 IL1B IL17A
3
Akt Signaling 63
Show member pathways
 13.4 TNFRSF10A TNF IL6 IL1B IL17A IL10
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.36 VEGFA TNF IL6 IL1B IL17A IL10
5
PAK Pathway 63
Show member pathways
 13.29 TNFRSF10A TNF IL6 IL1B IL17A IL10
6
TNFR1 Pathway 63
Show member pathways
 13.06 VEGFA TNFRSF10A TNFAIP3 TNF IL6 CD4
7
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.05 TNFAIP3 TNF IL6 IL1B IL10 ACE
8
Human cytomegalovirus infection 36
Show member pathways
 12.94 VEGFA TNF IL6 IL1B HLA-B CD4
9
Measles 36
Show member pathways
 12.83 TNFRSF10A TNFAIP3 TNF IL6 IL1B HLA-B
10
Allograft rejection 36 1
Show member pathways
 12.72 VEGFA TNF IL6 IL1B IL17A IL10
11
Th17 cell differentiation 36
Show member pathways
 12.61 TNF IL6 IL1B IL17A IL10 CD4
12
Immune response IL-23 signaling pathway 23
Show member pathways
 12.59 TNF IL6 IL1B IL17A IL10 CD4
13
NF-kappaB Signaling 4
12.56 TNFAIP3 TNF IL1B IL17A IL10 CD8A
14
T cell receptor signaling pathway 36
Show member pathways
 12.52 TNF IL6 IL1B IL17A IL10 CD8A
15
IL-17 Family Signaling Pathways 64
Show member pathways
 12.35 TNFAIP3 TNF IL6 IL1B IL17A
16
Human T-cell leukemia virus 1 infection 36
12.34 TNF IL6 HLA-B CD4
17
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.34 TNFRSF10A TNF IL6 IL10
18
Folate Metabolism 1
Show member pathways
 12.33 TNF IL6 IL1B CRP
19
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.28 TNF IL6 IL1B IL17A IL10 HLA-B
20
NOD-like receptor signaling pathway 36
12.23 TNFAIP3 TNF IL6 IL1B
21
Tuberculosis 36
12.23 TNF IL6 IL1B IL10
22
C-type lectin receptor signaling pathway 36
Show member pathways
 12.21 TNF IL6 IL1B IL10
23
Necroptosis 36
Show member pathways
 12.2 TNFRSF10A TNFAIP3 TNF IL1B
24
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.18 VEGFA TNF IL6 IL1B IL10
25
Yersinia infection 36
12.02 TNF IL6 IL1B IL10 CD8A CD4
26
TNF signaling pathway 36
12 TNFAIP3 TNF IL6 IL1B
27
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12 TNF IL6 IL10 CD8A CD4
28
Amoebiasis 36
11.95 TNF IL6 IL1B IL10
29
AGE-RAGE signaling pathway in diabetic complications 36
11.93 VEGFA TNF IL6 IL1B
30
Interleukin-4 and 13 signaling 65
11.9 VEGFA TNF IL6 IL1B IL17A IL10
31
Th17 Differentiation Pathway 64
Show member pathways
 11.89 IL6 IL1B IL17A CD4
32
Hematopoietic cell lineage 36
11.87 TNF IL6 IL1B CD8A CD4
33
Rheumatoid arthritis 36
11.82 VEGFA TNF IL6 IL1B IL17A
34
Pertussis 36
11.79 TNF IL6 IL1B IL10
35
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.71 VEGFA TNF IL6 IL1B
36
IgA-Producing B Cells in the Intestine 64
11.69 TNF IL6 IL10
37
Lung fibrosis 1
11.67 TNF IL6 IL1B
38
Innate Lymphoid Cell Differentiation Pathways 64
11.64 TNF IL1B IL17A IL10 CD8A CD4
39
Legionellosis 36
11.61 TNF IL6 IL1B
40
Malaria 36
11.56 TNF IL6 IL1B IL10
41
Interleukin-10 signaling 65
11.54 TNF IL6 IL1B IL10
42
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.49 TNF IL6 IL1B
43
African trypanosomiasis 36
11.39 TNF IL6 IL1B IL10
44
IL-10 Pathway 63
11.36 TNF IL6 IL1B IL10
45
Antifolate resistance 36
11.32 TNF IL6 IL1B
46
Th1 Differentiation Pathway 64
Show member pathways
 11.31 TNF IL6 IL1B IL17A IL10 CD4
47
Development and heterogeneity of the ILC family 1
11.3 TNF IL6 IL1B IL17A
48
Overview of nanoparticle effects 1
11.08 TNF IL6 CRP
49
Cytokines and Inflammatory Response 1
11.02 TNF IL6 IL1B IL10 CD4
50
G-protein signaling_Rap2B regulation pathway 23
11.01 TNF IL6 IL1B IL17A IL10
Sources

GO Terms for Iridocyclitis

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Cellular components related to Iridocyclitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 VEGFA TNF RBP3 IL6 IL1B IL17A
2 external side of plasma membrane GO:0009897 9.55 TNF IL17A CD8A CD4 ACE
3 extracellular region GO:0005576 9.32 VEGFA TNF RBP3 IL6 IL1B IL17A

Biological processes related to Iridocyclitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.05 VEGFA TNF IL6 IL1B CRP
2 positive regulation of protein phosphorylation GO:0001934 9.92 VEGFA TNF IL1B CD4
3 inflammatory response GO:0006954 9.91 TNFAIP3 TNF IL6 IL1B IL17A CRP
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 VEGFA TNF IL6
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 TNF IL6 IL1B IL10
6 defense response to Gram-negative bacterium GO:0050829 9.84 IL6 IL17A CD4
7 regulation of insulin secretion GO:0050796 9.82 TNF IL6 IL1B
8 negative regulation of interleukin-6 production GO:0032715 9.82 TNFAIP3 TNF IL10
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 VEGFA TNF IL6
10 defense response to Gram-positive bacterium GO:0050830 9.81 TNF IL6 IL17A CRP
11 response to glucocorticoid GO:0051384 9.8 TNF IL6 IL10
12 positive regulation of T cell proliferation GO:0042102 9.8 IL6 IL1B CD4
13 positive regulation of interleukin-8 production GO:0032757 9.79 TNF IL6 IL1B
14 positive regulation of interleukin-6 production GO:0032755 9.78 TNF IL6 IL1B IL17A
15 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF IL6 IL17A
16 cellular response to lipopolysaccharide GO:0071222 9.77 TNFAIP3 TNF IL6 IL1B IL10
17 positive regulation of JAK-STAT cascade GO:0046427 9.73 TNF IL6 IL10
18 negative regulation of neurogenesis GO:0050768 9.7 TNF IL6 IL1B
19 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.67 TNF IL6 IL17A
20 response to molecule of bacterial origin GO:0002237 9.66 TNFAIP3 IL10
21 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
22 neutrophil mediated immunity GO:0002446 9.65 IL6 ACE
23 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
24 positive regulation of glial cell proliferation GO:0060252 9.63 TNF IL6 IL1B
25 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
26 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.59 VEGFA ACE
27 positive regulation of fever generation GO:0031622 9.58 TNF IL1B
28 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 TNF IL1B IL10
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 TNF IL1B
31 negative regulation of gap junction assembly GO:1903597 9.54 IL1B ACE
32 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
33 cytokine-mediated signaling pathway GO:0019221 9.5 VEGFA TNF IL6 IL1B IL17A IL10
34 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
35 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
36 immune response GO:0006955 9.23 TNF IL6 IL1B IL17A IL10 HLA-B

Molecular functions related to Iridocyclitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 VEGFA UBAC2 TNFRSF10A TNFAIP3 TNF TMEM134
2 cytokine activity GO:0005125 9.1 VEGFA TNF IL6 IL1B IL17A IL10
Sources

Sources for Iridocyclitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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