MCID: IRN007
MIFTS: 26

Irinotecan Toxicity

Categories: Rare diseases

Aliases & Classifications for Irinotecan Toxicity

MalaCards integrated aliases for Irinotecan Toxicity:

Name: Irinotecan Toxicity 59

Classifications:



External Ids:

Orphanet 59 ORPHA240885

Summaries for Irinotecan Toxicity

MalaCards based summary : Irinotecan Toxicity is related to crigler-najjar syndrome, type i and glucosephosphate dehydrogenase deficiency. An important gene associated with Irinotecan Toxicity is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways/superpathways are Statin Pathway - Generalized, Pharmacokinetics and Steroid hormone biosynthesis. The drugs Irinotecan and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include testes.

Related Diseases for Irinotecan Toxicity

Graphical network of the top 20 diseases related to Irinotecan Toxicity:



Diseases related to Irinotecan Toxicity

Symptoms & Phenotypes for Irinotecan Toxicity

Drugs & Therapeutics for Irinotecan Toxicity

Drugs for Irinotecan Toxicity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Irinotecan Approved, Investigational Phase 4,Phase 2 97682-44-5, 100286-90-6 60838
2
Fluorouracil Approved Phase 4 51-21-8 3385
3
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
4
Camptothecin Experimental Phase 4,Phase 2 7689-03-4
5 topoisomerase I inhibitors Phase 4,Phase 2
6 Topoisomerase Inhibitors Phase 4,Phase 2
7 Antineoplastic Agents, Phytogenic Phase 4,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients Active, not recruiting NCT01271582 Phase 4 Irinotecan, 5FU, leucovorin
2 A Phase II Multicenter, Randomized, Placebo Controlled, Double Blinded Clinical Study of KD018 as a Modulator of Irinotecan Chemotherapy in Patients With Metastatic Colorectal Cancer Suspended NCT00730158 Phase 2 KD018;Irinotecan;Placebo

Search NIH Clinical Center for Irinotecan Toxicity

Genetic Tests for Irinotecan Toxicity

Anatomical Context for Irinotecan Toxicity

MalaCards organs/tissues related to Irinotecan Toxicity:

41
Testes

Publications for Irinotecan Toxicity

Articles related to Irinotecan Toxicity:

(show all 30)
# Title Authors Year
1
Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results ofA the PETACC-3 trial. ( 29909091 )
2018
2
Effect of UGT, SLCO, ABCB and ABCC polymorphisms on irinotecan toxicity. ( 29499902 )
2018
3
Pharmacokinetic and pharmacogenetic markers of irinotecan toxicity. ( 29932028 )
2018
4
Impact of diet on irinotecan toxicity in mice. ( 29913120 )
2018
5
Rapid and sensitive detection of UGT1A1 polymorphisms associated with irinotecan toxicity by a novel DNA microarray. ( 28474802 )
2017
6
Allelic expression of phase II metabolizing enzymes and relationship to irinotecan toxicity. ( 24969255 )
2014
7
Polymorphisms of uridine glucuronosyltransferase gene and irinotecan toxicity: low dose does not protect from toxicity. ( 24834123 )
2014
8
Prevalence of the UGT1A1*6 (c.211G>A) Polymorphism and Prediction of Irinotecan Toxicity in Iranian Populations of Different Ethnicities. ( 25967674 )
2014
9
The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats. ( 24454707 )
2014
10
Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer. ( 23631285 )
2012
11
Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice. ( 19931604 )
2010
12
[Assessment of total bilirubin or SN-38/SN-38G ratio as a predictor of severe irinotecan toxicity]. ( 19755821 )
2009
13
Irinotecan toxicity: genes or intestinal microflora? ( 19293816 )
2009
14
UGT1A and irinotecan toxicity: keeping it in the family. ( 19364959 )
2009
15
UGT1A1*28 and other UGT1A polymorphisms as determinants of irinotecan toxicity. ( 18467239 )
2008
16
Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients. ( 18082937 )
2008
17
Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. ( 18349289 )
2008
18
Clinical and pharmacogenetic factors associated with irinotecan toxicity. ( 18558463 )
2008
19
[Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. ( 18478930 )
2007
20
The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity. ( 17192505 )
2007
21
Irinotecan toxicity. ( 18660722 )
2007
22
Irinotecan toxicity to human blood cells in vitro: relationship between various biomarkers. ( 17516995 )
2007
23
Invader UGT1A1 molecular assay for irinotecan toxicity. A genetic test for an increased risk of toxicity from the cancer chemotherapy drug irinotecan (Camptosar). ( 16685247 )
2006
24
Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity. ( 16895999 )
2006
25
Genetic polymorphism in the phenobarbital-responsive enhancer module of the UDP-glucuronosyltransferase 1A1 gene and irinotecan toxicity. ( 15864124 )
2005
26
Pharmacogenetics of irinotecan toxicity. ( 15469406 )
2004
27
Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients. ( 12036456 )
2002
28
Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity. ( 12181419 )
2002
29
UGT1A1 polymorphism predicts irinotecan toxicity: evolving proof. ( 11783425 )
2001
30
Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. ( 11156391 )
2000

Variations for Irinotecan Toxicity

Expression for Irinotecan Toxicity

Search GEO for disease gene expression data for Irinotecan Toxicity.

Pathways for Irinotecan Toxicity

Pathways related to Irinotecan Toxicity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.37 SLCO1B1 UGT1A1
2
Show member pathways
11.22 UGT1A1 UGT1A7
3
Show member pathways
11.16 SLCO1B1 UGT1A1
4
Show member pathways
11.11 UGT1A1 UGT1A7
5
Show member pathways
10.84 SLCO1B1 UGT1A1
6 10.81 EGFR UGT1A1 UGT1A7
7
Show member pathways
10.66 SLCO1B1 TOP1 UGT1A1 UGT1A7
8
Show member pathways
10.54 EGFR UGT1A1

GO Terms for Irinotecan Toxicity

Biological processes related to Irinotecan Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 circadian rhythm GO:0007623 9.48 EGFR TOP1
2 liver development GO:0001889 9.46 EGFR UGT1A1
3 negative regulation of catalytic activity GO:0043086 9.43 UGT1A1 UGT1A7
4 cellular response to estradiol stimulus GO:0071392 9.4 EGFR UGT1A1
5 drug metabolic process GO:0017144 9.37 UGT1A1 UGT1A7
6 retinoic acid metabolic process GO:0042573 9.32 UGT1A1 UGT1A7
7 cellular glucuronidation GO:0052695 9.26 UGT1A1 UGT1A7
8 xenobiotic glucuronidation GO:0052697 9.16 UGT1A1 UGT1A7
9 flavonoid glucuronidation GO:0052696 8.96 UGT1A1 UGT1A7
10 flavone metabolic process GO:0051552 8.62 UGT1A1 UGT1A7

Molecular functions related to Irinotecan Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.54 EGFR UGT1A1 UGT1A7
2 transferase activity, transferring hexosyl groups GO:0016758 9.32 UGT1A1 UGT1A7
3 enzyme inhibitor activity GO:0004857 9.26 UGT1A1 UGT1A7
4 glucuronosyltransferase activity GO:0015020 9.16 UGT1A1 UGT1A7
5 retinoic acid binding GO:0001972 8.96 UGT1A1 UGT1A7
6 UDP-glycosyltransferase activity GO:0008194 8.62 UGT1A1 UGT1A7

Sources for Irinotecan Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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