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MCID: IRS003
MIFTS: 30

Iris Disease

Categories: Eye diseases
Genes Tissues Related diseases Pathways Drugs
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Aliases & Classifications for Iris Disease

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MalaCards integrated aliases for Iris Disease:

Name: Iris Disease 12 15
Iris Diseases 45 74

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:240
MeSH 45 D007499
NCIt 51 C34737
SNOMED-CT 69 85478004
UMLS 74 C0022078
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Summaries for Iris Disease

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MalaCards based summary : Iris Disease, also known as iris diseases, is related to aniridia 2 and morgagni cataract. An important gene associated with Iris Disease is PAX6 (Paired Box 6), and among its related pathways/superpathways is Mesodermal Commitment Pathway. The drugs Timolol and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina.

Wikipedia : 77 In humans and most mammals and birds, the iris (plural: irides or irises) is a thin, circular structure... more...

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Related Diseases for Iris Disease

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Diseases related to Iris Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 aniridia 2 10.3 ELP4 PAX6
2 morgagni cataract 10.3 CRYAA PHEX
3 isolated aniridia 10.3 FOXC1 PAX6
4 conjunctival degeneration 10.3 CRYAA PAX6
5 glaucoma-related pigment dispersion syndrome 10.3 LOXL1 PITX2
6 hereditary wilms' tumor 10.3 PAX6 WT1
7 enthesopathy 10.2 MRAP PHEX
8 axenfeld-rieger syndrome, type 2 10.2 FOXC1 PITX2
9 hydrophthalmos 10.2 FOXC1 PITX2
10 iridocyclitis 10.2 CRYAA MRAP
11 isolated foveal hypoplasia 10.2 PAX6 SLC38A8
12 anterior segment dysgenesis 4 10.2 FOXC1 PITX2
13 congenital aphakia 10.1 FOXE3 PAX6
14 pinguecula 10.1 CRYAA PAX6
15 axenfeld-rieger syndrome, type 3 10.1 FOXC1 PAX6 PITX2
16 axenfeld-rieger syndrome 10.1 FOXC1 PAX6 PITX2
17 phacogenic glaucoma 10.1 CRYAA LOXL1 PEX19 PHEX
18 intestinal atresia 10.1 FOXC1 PAX6 PITX2
19 glaucoma 3, primary congenital, a 10.1 FOXC1 PAX6 PITX2
20 congenital nystagmus 10.1 PAX6 SLC38A8
21 primary congenital glaucoma 10.0 FOXC1 PITX2
22 cataract 10.0 CRYAA FOXE3 PAX6
23 glaucomatocyclitic crisis 10.0 MRAP PITX2
24 persistent hyperplastic primary vitreous 10.0 FOXC1 PITX2
25 anterior segment dysgenesis 1 10.0 FOXE3 PAX6 PITX2
26 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 10.0 ELP4 FSHB PAX6 WT1
27 adamantinoma of long bones 10.0 FOXC1 PAX6 PITX2
28 juvenile glaucoma 9.9 FOXC1 PAX6 PHEX PITX2
29 axenfeld-rieger syndrome, type 1 9.9 PAX6 PITX2
30 uveal disease 9.8 LOXL1 MRAP PAX6 PEX19 PHEX
31 lens disease 9.8 CRYAA FOXE3 PAX6 PEX19 PHEX
32 peters-plus syndrome 9.8 FOXC1 FOXE3 PAX6 PITX2
33 anterior segment dysgenesis 9.4 FOXC1 FOXE3 PAX6 PITX2 SLC38A8
34 aniridia 1 8.1 DCDC1 ELP4 FOXC1 FOXE3 FSHB IMMP1L

Graphical network of the top 20 diseases related to Iris Disease:



Diseases related to Iris Disease
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Symptoms & Phenotypes for Iris Disease

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Drugs & Therapeutics for Iris Disease

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Drugs for Iris Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 125)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 4,Phase 3,Not Applicable 26839-75-8 5478 33624
2
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
3
Dorzolamide Approved Phase 4 120279-96-1 5284549 3154
4
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
5
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
8
Certolizumab pegol Approved Phase 4 428863-50-7
9
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
10
Bromfenac Approved July 1997 Phase 4 91714-94-2 60726
11 Adrenergic beta-Antagonists Phase 4,Phase 3,Not Applicable
12 Anti-Arrhythmia Agents Phase 4,Phase 3,Not Applicable
13 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Adrenergic Agents Phase 4,Phase 3,Not Applicable
15 Adrenergic Antagonists Phase 4,Phase 3,Not Applicable
16 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Ganciclovir triphosphate Phase 4,Phase 2,Phase 3,Not Applicable
21 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
23 Carbonic Anhydrase Inhibitors Phase 4,Not Applicable
24 calcium heparin Phase 4
25 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Analgesics Phase 4,Not Applicable
32 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Antirheumatic Agents Phase 4,Not Applicable
35 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Analgesics, Non-Narcotic Phase 4,Not Applicable
37 Anti-Bacterial Agents Phase 4,Phase 1
38 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Antibiotics, Antitubercular Phase 4,Phase 1
40 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Not Applicable
43
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Melanocyte-Stimulating Hormones Phase 4,Not Applicable
45 beta-endorphin Phase 4,Not Applicable
46 Adrenocorticotropic Hormone Phase 4,Not Applicable
47 Immunologic Factors Phase 4,Phase 2,Phase 1
48 Immunosuppressive Agents Phase 4,Phase 2,Phase 1
49
Pilocarpine Approved, Investigational Phase 3,Not Applicable 54-71-7, 92-13-7 5910
50
Difluprednate Approved Phase 3,Phase 2 23674-86-4 443936

Interventional clinical trials:

(show top 50) (show all 95)
# Name Status NCT ID Phase Drugs
1 Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT01357122 Phase 4
2 Assessing Cosopt Switch Patients Completed NCT00273442 Phase 4 timolol maleate;dorzolamide/timolol maleate fixed combination
3 Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties Completed NCT01767012 Phase 4
4 Bromfenac to Reduce Inflammation in Patients With Pseudoexfoliation Syndrome After Cataract Surgery Completed NCT02137161 Phase 4 Dexamethasone+Tobramycin eye drop;Bromfenac eye drop
5 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
6 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
7 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
8 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Terminated NCT02769702 Phase 4 Acthar
9 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
10 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
11 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
12 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
13 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
14 Randomized Prospective Study of Selective Laser Trabeculoplasty (SLT) Versus Argon Trabeculoplasty (ALT) in Patients With Pseudoexfoliation Glaucoma and Ocular Hypertension Completed NCT01126203 Phase 3
15 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination Completed NCT00331240 Phase 3 travoprost/timolol fixed combination;placebo (artificial tears)
16 SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
17 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes Not yet recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
18 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis Not yet recruiting NCT03576898 Phase 2, Phase 3 Topical ganciclovir versus oral valganciclovir versus placebo
19 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
20 Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
21 A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
22 Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
23 Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis Completed NCT00823173 Phase 2
24 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
25 A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma Completed NCT01936389 Phase 2 AR-12286
26 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
27 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
28 Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy Recruiting NCT03575130 Phase 2 Ripasudil eye drops;Optive eye drops
29 A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED) Active, not recruiting NCT02653391 Phase 1, Phase 2 Elamipretide 1.0% Ophthalmic Solution;Elamipretide 3.0% Ophthalmic Solution
30 Study of Ataluren in Participants With Nonsense Mutation Aniridia Active, not recruiting NCT02647359 Phase 2 Ataluren;Placebo
31 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Completed NCT00876434 Phase 1 Sirolimus
32 Quality of Life and Visual Function in Uveitis Patients Unknown status NCT00407316
33 Following Patients After Selective and Pascal Laser Trabeculoplasty for Treatment of Chronic Open-Angle Glaucoma Unknown status NCT02679482
34 Comparison of the Capsular Stability With Two Different IOL Models in Patients With Pseudoexfoliation Syndrome: an Exploratory Study Unknown status NCT02155478 Not Applicable
35 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
36 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
37 LOXL1 Polymorphism in Pseudoexfoliation Syndrome Unknown status NCT01515735
38 The International Collaborative Exfoliation Syndrome Treatment Study Unknown status NCT00804115 Not Applicable Latanoprost with Pilocarpine vs Timolol or Cosopt
39 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty Unknown status NCT00744796 Not Applicable
40 Efficacy of a Capsular Tension Ring in Preventing Anterior Capsule Shrinkage After Cataract Surgery in Exfoliation Syndrome Unknown status NCT01455168
41 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
42 Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis Unknown status NCT02879084
43 The Diurnal and Nocturnal Effect of Simbrinza and Timolol on Intraocular Pressure and Ocular Perfusion Pressure Completed NCT02165631
44 Adherence With Fixed Versus Unfixed Glaucoma Therapy Completed NCT01281020
45 Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan Completed NCT00121147 Not Applicable Travatan;Azopt;Alphagan P
46 Micropulse Laser Trabeculoplasty as Adjunctive Treatment in Patients With Pseudoexfoliation Glaucoma Completed NCT03483402 Not Applicable
47 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Not Applicable Ganciclovir
48 Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty Completed NCT00485108 Not Applicable prednisolone 1%;ketorolac 0.5%;Artificial Tears (Methyl cellulose drops)
49 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010 Not Applicable
50 Optical Low Coherence Reflectometry Enables Preoperative Detection of Zonular Weakness in Pseudoexfoliation Syndrome Completed NCT01298895

Search NIH Clinical Center for Iris Disease

Cochrane evidence based reviews: iris diseases

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Genetic Tests for Iris Disease

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Anatomical Context for Iris Disease

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MalaCards organs/tissues related to Iris Disease:

42
Eye, Endothelial, Retina, Testes, Bone
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Publications for Iris Disease

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Variations for Iris Disease

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Expression for Iris Disease

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Search GEO for disease gene expression data for Iris Disease.
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Pathways for Iris Disease

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Pathways related to Iris Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Mesodermal Commitment Pathway 1
Show member pathways
 11.41 ELP4 FOXC1 PAX6 PITX2
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GO Terms for Iris Disease

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Biological processes related to Iris Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.91 ELP4 FOXC1 FOXE3 PAX6 PITX2 WT1
2 positive regulation of gene expression GO:0010628 9.76 FOXC1 FSHB PAX6 WT1
3 anatomical structure morphogenesis GO:0009653 9.58 FOXC1 FOXE3 PITX2
4 ureteric bud development GO:0001657 9.49 FOXC1 WT1
5 lens development in camera-type eye GO:0002088 9.48 FOXE3 PAX6
6 transcription by RNA polymerase II GO:0006366 9.37 FOXE3 PAX6
7 eye development GO:0001654 9.33 FOXC1 FOXE3 PAX6
8 cornea development in camera-type eye GO:0061303 9.32 FOXE3 PAX6
9 lacrimal gland development GO:0032808 9.26 FOXC1 PAX6
10 iris morphogenesis GO:0061072 9.13 FOXE3 PAX6 PITX2
11 camera-type eye development GO:0043010 9.02 FOXC1 FOXE3 PAX6 PITX2 WT1

Molecular functions related to Iris Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.35 FOXC1 FOXE3 PAX6 PITX2 WT1
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.33 FOXC1 PAX6 WT1
3 sequence-specific DNA binding GO:0043565 9.02 FOXC1 FOXE3 PAX6 PITX2 WT1
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Sources for Iris Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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