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MCID: IRT001
MIFTS: 45

Iritis

Categories: Eye diseases, Neuronal diseases
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Aliases & Classifications for Iritis

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MalaCards integrated aliases for Iritis:

Name: Iritis 11 75 43 14 16 71 75

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:1406
MeSH 43 D007500
NCIt 49 C50621
SNOMED-CT 68 65074000
UMLS 71 C0022081
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Summaries for Iritis

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MalaCards based summary: Iritis is related to severe cutaneous adverse reaction and juvenile rheumatoid arthritis. An important gene associated with Iritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Difluprednate and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Wikipedia: 75 Uveitis (/ˌjuːvɪaɪtɪs/) is inflammation of the uvea, the pigmented layer of the eye between the inner... more...
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Related Diseases for Iritis

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Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1057)
# Related Disease Score Top Affiliating Genes
1 severe cutaneous adverse reaction 30.5 TNF IL6 HLA-B HLA-A CRP CD8A
2 juvenile rheumatoid arthritis 30.2 TNF IL6 CRP CD4 CCR6
3 scleritis 30.1 TNF CRP CCR6
4 rubeosis iridis 30.1 VEGFA IL6
5 arthropathy 30.0 TNF NOD2 IL6 CRP CCR6
6 deep keratitis 30.0 RBP3 CRP
7 pouchitis 30.0 TNF NOD2
8 coccidioidomycosis 30.0 IL17A CD4 CCR6
9 reactive arthritis 29.9 TNF IL17A HLA-B ERAP1 CRP CCR6
10 neutrophilic dermatosis, acute febrile 29.9 TNF IL17A CRP
11 spondyloarthropathy 1 29.9 TNF NOD2 IL6 IL17A IL10 HLA-B
12 acute kidney failure 29.9 IL6 ALB ACE
13 conjunctivitis 29.9 TNF IL6 IL10 HLA-B
14 cataract 29.9 VEGFA TNF IL6 CRP ALB ACE
15 osteoarthritis 29.9 TNF IL6 IL17A CRP
16 neovascular glaucoma 29.8 VEGFA IL6 EPO
17 optic papillitis 29.8 TNF RBP3 CRP CD4 ACE
18 typhoid fever 29.8 TNF IL6 CRP CCR6 ALB
19 blau syndrome 29.8 TNF NOD2 IL10
20 corneal ulcer 29.8 VEGFA TNF IL6
21 pericarditis 29.8 TNF IL6 CRP ACE
22 macular dystrophy, dominant cystoid 29.8 VEGFA TNF RBP3 IL6 ACE
23 lyme disease 29.7 TNF IL6 IL17A CRP
24 macular retinal edema 29.7 VEGFA TNF IL6 ALB ACE
25 gout 29.7 TNF IL6 HLA-B CRP ALB
26 mumps 29.6 TNF IL6 IL10
27 thrombocytosis 29.6 IL6 EPO CRP ALB
28 anterior uveitis 29.6 VEGFA TNF RBP3 IL6 IL17A IL10
29 fuchs' heterochromic uveitis 29.5 IL6 IL10 ACE
30 cysticercosis 29.5 IL6 IL10 CD4
31 paine syndrome 29.5 TNF IL6 IL10
32 erythema nodosum 29.5 TNF NOD2 IL6 IL10 CRP
33 secondary syphilis 29.4 TNF CRP CD8A CD4 ACE
34 lipid storage disease 29.4 TNF IL6 CRP CCR6 ALB
35 dermatitis herpetiformis 29.4 TNF IL17A IL10 HLA-B
36 chlamydia 29.3 TNF IL6 IL17A IL10 CRP
37 endophthalmitis 29.3 VEGFA TNF RBP3 IL6 CRP CD4
38 vitiligo-associated multiple autoimmune disease susceptibility 1 29.2 TNF IL17A HLA-B CD8A CD4 CCR6
39 interstitial nephritis 29.2 TNF CRP CD8A CD4 CCR6 ALB
40 inflammatory bowel disease 1 29.2 TNF NOD2 IL6 IL17A IL10 CCR6
41 syphilis 29.2 TNF IL17A CRP CD8A CD4 CCR6
42 spondylitis 29.2 TNF NOD2 IL6 IL17A IL10 HLA-B
43 brucellosis 29.2 TNF IL6 IL17A IL10 HLA-B CRP
44 herpes zoster 29.1 IL10 HLA-B HLA-A CD8A CD4 CCR6
45 hypersensitivity vasculitis 29.1 TNF IL6 CRP CD4 CCR6 ALB
46 lepromatous leprosy 29.0 TNF IL10 CD8A CD4 CCR6
47 ulcerative colitis 29.0 TNF NOD2 IL6 IL17A IL10 CRP
48 vasculitis 29.0 TNF IL6 IL17A IL10 HLA-B CRP
49 melanoma, uveal 29.0 VEGFA HLA-B HLA-A CD8A CD4
50 keratitis, hereditary 29.0 VEGFA TNF IL6 IL17A IL10 CD8A

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis
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Symptoms & Phenotypes for Iritis

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GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.11 ACE ALB CCR6 CD4 CD8A CRP
2 no effect GR00402-S-2 10.11 ACE ALB CCR6 CD4 CRP EPO
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.7 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.7 CD4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.7 CD4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.7 CD4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.7 CD4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.7 NOD2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.7 CD4
10 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.7 NOD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.7 HLA-A HLA-B

MGI Mouse Phenotypes related to Iritis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACE ALB CCR6 CD4 CRP EPO
2 nervous system MP:0003631 10.22 CCR6 CD4 CD8A HLA-A HLA-B IL10
3 endocrine/exocrine gland MP:0005379 10.21 ACE ALB CD4 CD8A ERAP1 HLA-A
4 no phenotypic analysis MP:0003012 10.15 CD4 ERAP1 HLA-A HLA-B IL10 IL17A
5 liver/biliary system MP:0005370 10.09 ACE ALB EPO ERAP1 IL10 IL17A
6 immune system MP:0005387 10.09 ACE ALB CCR6 CD4 CD8A CRP
7 renal/urinary system MP:0005367 10.06 ACE ALB CD8A ERAP1 IL17A IL6
8 neoplasm MP:0002006 10.05 ACE ALB IL10 IL6 PTGER2 TNF
9 cardiovascular system MP:0005385 10 ACE ALB CCR6 CRP EPO HLA-B
10 digestive/alimentary MP:0005381 9.97 ALB CD4 HLA-B IL10 IL17A IL6
11 hematopoietic system MP:0005397 9.83 ACE CCR6 CD4 CD8A EPO ERAP1
12 mortality/aging MP:0010768 9.47 ACE ALB CD4 CD8A EPO HLA-A
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Drugs & Therapeutics for Iritis

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Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Difluprednate Approved Phase 2 23674-86-4 443936
2
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
3
Daclizumab Investigational, Withdrawn Phase 2 152923-56-3
4
Triamcinolone hexacetonide Phase 2
5
Triamcinolone diacetate Phase 2
6
Triamcinolone Acetonide Phase 2 6436
7 Immunosuppressive Agents Phase 2
8 Immunologic Factors Phase 2
9
Lactitol Approved, Investigational 585-86-4 157355
10
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3 3680
11
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 3003 5743
12
Diclofenac Approved, Vet_approved 15307-86-5, 15307-79-6 3033
13 Cathartics
14 Antirheumatic Agents
15 Laxatives
16 Cyclooxygenase Inhibitors
17 Anti-Inflammatory Agents, Non-Steroidal
18 Pharmaceutical Solutions
19 Ophthalmic Solutions
20 BB 1101
21 Analgesics, Non-Narcotic
22 Analgesics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Inluding Iritis, Cyclitis, Iridocyclitis, and Panuveitis). Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
2 Treatment of Active Anterior Uveitis Associated With JIA, Using Humanized Anti-Tac (HAT, Daclizumab) Completed NCT00130637 Phase 2 Daclizumab
3 Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function. Completed NCT00476593 Diclofenac;Dexamethasone
4 Evaluation and Treatment Protocol for Patients With Intraocular Inflammatory Disease (Uveitis) Completed NCT00006188
5 Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Ocular Inflammatory or Immunologic Diseases Completed NCT00001734
6 PEMF an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
7 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Withdrawn NCT02416128 Euphrasia;Prednisolone acetate

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Loteprednol
loteprednol etabonate
Tropicamide

Cochrane evidence based reviews: iritis

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Genetic Tests for Iritis

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Anatomical Context for Iritis

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Organs/tissues related to Iritis:

MalaCards : Eye, Retina, Endothelial, Lymph Node, Skin, Lung, Brain
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Publications for Iritis

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Articles related to Iritis:

(show top 50) (show all 1347)
# Title Authors PMID Year
1
Bilateral posterior scleritis due to giant cell arteritis. 62
36428030 2022
2
Complications of manual small-incision cataract surgery. 62
36308100 2022
3
Epidemiology and characteristics of common forms of anterior uveitis at initial presentation in a tertiary facility in Japan. 62
36346554 2022
4
Evaluation of efficacy of intracameral lidocaine and tropicamide injection in manual small-incision cataract surgery: A prospective clinical study. 62
36308110 2022
5
OCULAR INJURIES ASSOCIATED WITH ELASTIC EXERCISE BANDS. 62
33165305 2022
6
Effectiveness of Topical Ganciclovir 2% Monotherapy Versus Combined Steroid Therapy in Cytomegalovirus Endotheliitis. 62
36233679 2022
7
Acute Onset Endophthalmitis Following Bilateral Upper and Lower Eyelid Blepharoplasty. 62
35470337 2022
8
Response to Letter to the Editor: Self-Identified Black Race as a Risk Factor for Intraocular Pressure Elevation and Iritis Following Prophylactic Laser Peripheral Iridotomy. 62
35797698 2022
9
Letter to the Editor: Self-Identified Black Race as a Risk Factor for Intraocular Pressure Elevation and Iritis Following Prophylactic Laser Peripheral Iridotomy. 62
35797696 2022
10
Ocular mycobacterial lesions in cats. 62
35587045 2022
11
Bilateral microsporidial keratoconjunctivitis in a clinically healthy female receiving intravitreal steroid injections: Associations and potential risk factors. 62
35865661 2022
12
Younger Age and Longer Case Times Associated With Emergency Department Visits After Cataract Surgery. 62
36029826 2022
13
COMPARISON OF POST CATARACT SURGERY ANTI-INFLAMMATORY REGIMENS ON THE INCIDENCE OF CYSTOID MACULAR EDEMA, IRITIS, PAIN, AND PHOTOPHOBIA. 62
35862832 2022
14
Short-term results for brolucizumab in treatment-naïve neovascular age-related macular degeneration: a Japanese multicenter study. 62
35595951 2022
15
A Comparative Study on Accuracy of SRK-T And Haigis Formulas in IOL Power Calculation in Axial Myopes Undergoing Cataract Surgery. 62
36110819 2022
16
One-Year Efficacy and Safety of Omidenepag Isopropyl in Patients with Normal-Tension Glaucoma. 62
35613407 2022
17
Manual small incision cataract surgery: a viable option for cataract with pseudoexfoliation. 62
34839453 2022
18
Zoster Eye Disease Study: Rationale and Design. 62
35090154 2022
19
COVID-19 Hospitalizations, Intensive Care Unit Stays, Ventilation, and Death Among Patients With Immune-mediated Inflammatory Diseases Compared to Controls. 62
35105713 2022
20
Self-identified Black Race as a Risk Factor for Intraocular Pressure Elevation and Iritis Following Prophylactic Laser Peripheral Iridotomy. 62
35131983 2022
21
Peripheral Ulcerative Keratitis: A Review. 62
35765625 2022
22
Ocular Adverse Events after Inactivated COVID-19 Vaccination in Xiamen. 62
35335114 2022
23
Diagnosis and Management of Idiopathic Persistent Iritis after Cataract Surgery (IPICS). 62
34653354 2022
24
Severe fishhook-related ocular injury: A case series. 62
34917740 2022
25
COVID-19 mRNA Vaccine-Associated Uveitis Leading to Diagnosis of Sarcoidosis: Case Report and Review of Literature. 62
35313760 2022
26
Analysis of urgent follow up visits and complications after intravitreal injections: a retrospective cohort study. 62
35042547 2022
27
A Case of an Intraorbital Wooden Chip Foreign Body Diagnosed and Removed Several Months after Injury Despite Repeated Imaging Study. 62
35350231 2022
28
Liposomal drug delivery system for anti-inflammatory treatment after cataract surgery: a phase I/II clinical trial. 62
33569720 2022
29
Super aggregated amphotericin B with a thermoreversible in situ gelling ophthalmic system for amoebic keratitis treatment. 62
34562424 2021
30
Efficacy of intravitreal povidone-iodine administration for the treatment of Candida albicans endophthalmitis in rabbits. 62
34637791 2021
31
Sutured Custom Foldable Silicone Artificial Iris Implantation Combined With Intraocular Lens Implantation and Penetrating Keratoplasty: Safety and Efficacy Outcomes. 62
33086281 2021
32
[Ocular manifestations of toxocariasis in schoolchildren from the state from the Anzoátegui state in Venezuela]. 62
35385016 2021
33
Factors relating to bone mineral density in young and middle-aged patients with ankylosing spondylitis. 62
34653076 2021
34
[Unusual iritis-A case report of endophthalmitis caused by Listeria monocytogenes]. 62
33103228 2021
35
Rebound iritis with a well-circumscribed anterior chamber fibrin mass after uncomplicated cataract surgery. 62
34637008 2021
36
[Ocular ischemic syndrome : An important differential diagnosis]. 62
32975660 2021
37
Sterile iris abscess associated with herpes zoster ophthalmicus. 62
34195477 2021
38
Tubulointerstitial nephritis and uveitis syndrome following meningitis and systemic lymphadenopathy with persistent Toxoplasma immunoglobulin M: a case report. 62
34556154 2021
39
Understanding COVID-19 Risk in Patients With Immune-Mediated Inflammatory Diseases: A Population-Based Analysis of SARS-CoV-2 Testing. 62
34486829 2021
40
Effects of Neodymium-Doped Yttrium Aluminium Garnet (Nd:YAG) Laser Capsulotomy on Visual Outcomes From a Lower-Middle Income Country. 62
34660093 2021
41
Repositioning surgery of different intraocular lens designs in eyes with late in-the-bag intraocular lens dislocation. 62
33754659 2021
42
Anti-Neutrophil Cytoplasmic Antibody-Associated Ocular Manifestations in Japan: A Review of 18 Patients. 62
32078414 2021
43
Patient-Reported Complications after Intravitreal Injection and Their Predictive Factors. 62
33059077 2021
44
A Rare Case of Renal Sarcoidosis. 62
34268026 2021
45
A Retrospective Study of Herpetic Keratitis in Patients with Keratoconus after Crosslinking Surgery. 62
34207081 2021
46
A Rare Autoinflammatory Syndrome Involving Acute Severe Ulcerative Colitis Combined With Iritis. 62
33694367 2021
47
Castleman's disease masquerading as pancreatic neuroendocrine tumour. 62
34167983 2021
48
Unilateral Ocular Siderosis Bulbi Due to Missed Metallic Intraocular Foreign Body Masquerading as Anisocoria of Neurological Origin: A Case Report. 62
33947824 2021
49
Clinical features of uveitis in elderly patients in central Tokyo (2013-2018). 62
33544350 2021
50
Case of Macular Hole Secondary to Ocular Toxoplasmosis Treated Successfully by Vitrectomy with Inverted Internal Limiting Membrane Flap. 62
34054485 2021
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Variations for Iritis

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Expression for Iritis

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Search GEO for disease gene expression data for Iritis.
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Pathways for Iritis

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Pathways related to Iritis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.84 VEGFA TNF NOD2 IL6 IL17A IL10
2
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.57 VEGFA TNF IL6 IL17A IL10 EPO
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.23 CD4 HLA-A HLA-B IL10 IL17A IL6
4
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.57 TNF IL6 IL17A IL10 HLA-B HLA-A
5
Immune response IL-23 signaling pathway 22
Show member pathways
 12.53 TNF IL6 IL17A IL10 CD4
6
Colorectal Cancer Metastasis 64
12.14 VEGFA TNF PTGER2 IL6
7
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.11 VEGFA TNF IL6 IL10
8
T-cell activation SARS-CoV-2 74
Show member pathways
 12.09 TNF IL17A IL10 CD8A CD4
9
Interleukin-4 and Interleukin-13 signaling 66
11.89 VEGFA TNF IL6 IL17A IL10
10
CCL18 signaling pathway 74
11.86 VEGFA IL6 IL10 CCR6
11
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.86 TNF IL6 IL10 EPO CD8A CD4
12
IL27-mediated signaling events 61
Show member pathways
 11.83 CD4 IL10 IL17A IL6 TNF
13
Th17 Differentiation 65
Show member pathways
 11.81 IL6 IL17A CD4
14
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.75 IL6 CRP CD8A CD4
15
Burn wound healing 74
11.72 VEGFA TNF IL6
16
Acute viral myocarditis 74
11.72 IL6 IL10 CD4
17
Extrafollicular B cell activation by SARS-CoV-2 74
11.7 TNF IL6 IL10 CRP
18
Allograft rejection 74
11.7 VEGFA TNF IL17A IL10 HLA-B HLA-A
19
AP-1 transcription factor network 61
11.67 HLA-A IL10 IL6
20
Th17 cell differentiation pathway 74
11.67 CD4 IL17A IL6
21
Dendritic Cells Developmental Lineage Pathway 65
11.64 TNF IL6 IL10 CD8A CD4
22
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.63 VEGFA TNF IL6
23
miRNAs involvement in the immune response in sepsis 74
11.62 TNF IL6 IL10
24
IL 10 signaling pathway 67
11.61 TNF IL6 IL10
25
Inflammatory bowel disease signaling 74
Show member pathways
 11.61 IL10 IL6 NOD2 TNF
26
Innate Lymphoid Cells Differentiation 65
11.54 TNF IL17A IL10 CD8A CD4 CCR6
27
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.52 TNF NOD2 IL6
28
Pluripotent stem cell differentiation pathway 74
11.49 EPO IL6 VEGFA
29
Interleukin-10 signaling 66
11.47 TNF IL6 IL10
30
IL-10 Pathway 64
11.32 TNF IL6 IL10
31
Development and heterogeneity of the ILC family 74
11.27 IL17A IL6 TNF
32
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 66
11.22 HLA-B HLA-A ERAP1
33
Cytokines and inflammatory response 74
11.17 TNF IL6 IL10 CD4
34
Overview of nanoparticle effects 74
11.02 TNF IL6 CRP
35
Prostaglandin signaling 74
10.8 VEGFA TNF PTGER2 IL6 IL17A
36
Immune infiltration in pancreatic cancer 74
10.45 VEGFA TNF IL6 IL17A IL10
37
Cells and molecules involved in local acute inflammatory response 74
Show member pathways
 10.34 TNF IL6
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GO Terms for Iritis

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Cellular components related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.3 ACE ALB CRP EPO ERAP1 IL10
2 plasma membrane GO:0005887 10.23 ACE CCR6 CD4 CD8A HLA-A HLA-B
3 plasma membrane GO:0005886 10.23 ACE CCR6 CD4 CD8A HLA-A HLA-B
4 external side of plasma membrane GO:0009897 10.1 TNF IL17A CD8A CD4 CCR6 ACE
5 extracellular region GO:0005576 10.03 ACE ALB CD8A CRP EPO ERAP1
6 cell surface GO:0009986 9.5 VEGFA TNF NOD2 HLA-B HLA-A EPO

Biological processes related to Iritis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.32 IL17A HLA-B HLA-A ERAP1 CD8A CD4
2 negative regulation of apoptotic process GO:0043066 10.31 ALB EPO IL10 IL6 TNF VEGFA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.19 VEGFA TNF NOD2 EPO CD4
4 positive regulation of interleukin-6 production GO:0032755 10.15 TNF NOD2 IL6 IL17A
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.13 CD4 IL6 NOD2 VEGFA
6 response to activity GO:0014823 10.1 TNF IL6 IL10
7 acute-phase response GO:0006953 10.08 IL6 EPO CRP
8 positive regulation of MAPK cascade GO:0043410 10.08 VEGFA TNF NOD2 IL6 CD4
9 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.06 IL10 IL6 TNF
10 positive regulation of interleukin-1 beta production GO:0032731 10.06 IL17A IL6 NOD2 TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.04 VEGFA TNF IL6 EPO
12 liver regeneration GO:0097421 10.03 IL10 IL6 TNF
13 immune system process GO:0002376 9.98 NOD2 IL17A HLA-B HLA-A ERAP1 CD8A
14 protection from natural killer cell mediated cytotoxicity GO:0042270 9.94 HLA-B HLA-A
15 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.93 TNF NOD2
16 negative regulation of cytokine production involved in immune response GO:0002719 9.92 TNF IL10
17 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.92 HLA-B HLA-A
18 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.92 TNF NOD2 IL6 IL17A
19 response to lipopolysaccharide GO:0032496 9.91 TNF PTGER2 NOD2 IL10 EPO ACE
20 negative regulation of interleukin-18 production GO:0032701 9.9 NOD2 IL10
21 defense response to Gram-positive bacterium GO:0050830 9.9 CRP HLA-A IL17A IL6 NOD2 TNF
22 antigen processing and presentation GO:0019882 9.89 CD8A HLA-A HLA-B
23 detection of bacterium GO:0016045 9.88 NOD2 HLA-B HLA-A
24 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.87 VEGFA ACE
25 negative regulation of lipid storage GO:0010888 9.85 CRP IL6 TNF
26 chronic inflammatory response to antigenic stimulus GO:0002439 9.81 TNF IL10
27 immune response GO:0006955 9.5 TNF IL6 IL17A IL10 HLA-B HLA-A
28 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 HLA-B HLA-A ERAP1 ACE

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.4 VEGFA TNF IL6 IL17A IL10 EPO
2 TAP binding GO:0046977 9.26 HLA-B HLA-A
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Sources for Iritis

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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