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MCID: IRT001
MIFTS: 37

Iritis

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Iritis

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MalaCards integrated aliases for Iritis:

Name: Iritis 12 75 44 15 17 72

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1406
MeSH 44 D007500
NCIt 50 C50621
SNOMED-CT 68 65074000
UMLS 72 C0022081
Sources

Summaries for Iritis

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MalaCards based summary : Iritis is related to spondyloarthropathy 1 and iridocyclitis. An important gene associated with Iritis is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Inflammatory Response Pathway. The drugs Antiviral Agents and valacyclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related phenotype is Increased shRNA abundance.

Wikipedia : 75 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

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Related Diseases for Iritis

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Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 32.0 TNFRSF1B MRAP HLA-B
2 iridocyclitis 31.1 MRAP HLA-B
3 spondylitis 30.6 TNFRSF1B HLA-B
4 acquired immunodeficiency syndrome 30.2 HLA-B EPO
5 rheumatic disease 29.9 HLA-B CD40LG
6 pustulosis of palm and sole 29.6 TNFRSF1B MRAP
7 bone inflammation disease 29.3 TNFRSF1B MRAP
8 vasculitis 29.2 TNFRSF1B HLA-B CD40LG
9 panuveitis 29.2 TNFRSF1B MRAP HLA-B
10 behcet syndrome 29.1 TNFRSF1B MRAP HLA-B
11 endotheliitis 11.6
12 norrie disease 11.4
13 severe cutaneous adverse reaction 11.2
14 uveitis 10.5
15 anterior uveitis 10.5
16 intraocular pressure quantitative trait locus 10.4
17 inflammatory spondylopathy 10.4
18 cataract 10.4
19 keratitis, hereditary 10.3
20 hypopyon 10.3
21 toxic optic neuropathy 10.3 MRAP EPO
22 sarcoidosis 1 10.3
23 herpes simplex 10.3
24 glaucomatocyclitic crisis 10.2 MRAP HLA-B
25 syphilis 10.2
26 yemenite deaf-blind hypopigmentation syndrome 10.2
27 neuroretinitis 10.2
28 retinitis 10.2
29 conjunctivitis 10.1
30 juvenile rheumatoid arthritis 10.1
31 blau syndrome 10.1
32 exanthem 10.1
33 colitis 10.1
34 cytomegalovirus retinitis 10.1
35 interstitial nephritis 10.1
36 open-angle glaucoma 10.1
37 diabetic autonomic neuropathy 10.1
38 autonomic neuropathy 10.1
39 typhoid fever 10.1
40 enthesopathy 10.1
41 endophthalmitis 10.1
42 arthritis 10.1
43 herpes zoster 10.1
44 chickenpox 10.1
45 neuropathy 10.1
46 meningitis 10.1
47 47,xyy 10.1
48 herpes zoster ophthalmicus 10.1
49 rubella 10.1 HLA-B CD40LG
50 bladder cancer 10.0

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis
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Symptoms & Phenotypes for Iritis

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GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CNOT1 EPO HLA-B
Sources

Drugs & Therapeutics for Iritis

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Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antiviral Agents Phase 4
2 valacyclovir Phase 4
3
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
4
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
5
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
6
Acetazolamide Approved, Vet_approved Phase 2, Phase 3 59-66-5 1986
7
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
8
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
9
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
10
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
11 Anti-Inflammatory Agents Phase 2, Phase 3
12 Analgesics Phase 2, Phase 3
13 Cyclooxygenase Inhibitors Phase 2, Phase 3
14 Peripheral Nervous System Agents Phase 2, Phase 3
15 Analgesics, Non-Narcotic Phase 2, Phase 3
16 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
17 Antirheumatic Agents Phase 2, Phase 3
18 Narcotics Phase 2, Phase 3
19 Central Nervous System Depressants Phase 2, Phase 3
20 Fibrinolytic Agents Phase 2, Phase 3
21 diuretics Phase 2, Phase 3
22 Natriuretic Agents Phase 2, Phase 3
23 Respiratory System Agents Phase 2, Phase 3
24 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
25 Analgesics, Opioid Phase 2, Phase 3
26 Platelet Aggregation Inhibitors Phase 2, Phase 3
27 Anticonvulsants Phase 2, Phase 3
28 Antitussive Agents Phase 2, Phase 3
29 Antipyretics Phase 2, Phase 3
30 Carbonic Anhydrase Inhibitors Phase 2, Phase 3
31
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
32
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
33
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
34
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
35
Difluprednate Approved Phase 2 23674-86-4 443936
36
Fluprednisolone Approved Phase 2 53-34-9
37
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
38
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
39 Antiemetics Phase 2
40 Gastrointestinal Agents Phase 2
41 Antineoplastic Agents, Hormonal Phase 2
42 Autonomic Agents Phase 2
43 Neuroprotective Agents Phase 2
44 Methylprednisolone Acetate Phase 2
45 Protective Agents Phase 2
46 Prednisolone acetate Phase 2
47 glucocorticoids Phase 2
48 Hormones Phase 2
49 Hormone Antagonists Phase 2
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
2 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
3 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
4 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2 Euphrasia;Prednisolone acetate
5 Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Inluding Iritis, Cyclitis, Iridocyclitis, and Panuveitis). Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
6 Treatment of Active Anterior Uveitis Associated With JIA, Using Humanized Anti-Tac (HAT, Daclizumab) Completed NCT00130637 Phase 2 Daclizumab
7 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1 Chicken type II collagen
8 Postoperative Events in Patients With and Without Retained Nuclear Fragments in the Anterior Vitreous After Routine Phacoemulsification Unknown status NCT02058394
9 EyeKon Medical, Inc. Capsular Tension Ring Clinical Study Unknown status NCT02332369
10 PEMF an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
11 Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Ocular Inflammatory or Immunologic Diseases Completed NCT00001734
12 Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function. Completed NCT00476593 Diclofenac;Dexamethasone
13 Evaluation and Treatment Protocol for Patients With Intraocular Inflammatory Disease (Uveitis) Completed NCT00006188
14 Evaluation of the Acrysof Toric SN60T3 Intraocular Lens in Patients With Predicted Residual Corneal Astigmatism Between 0.75 and 1.00 D. Completed NCT00542581
15 Connection Between Periodontitis and Exudative Age-related Macular Degeneration Not yet recruiting NCT03958461

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Corticotropin
Cortisone acetate
Dexamethasone
Hydrocortisone
Loteprednol
Loteprednol
loteprednol etabonate
Methylprednisolone
Prednisolone
Prednisone
Tetracosactide
Tropicamide

Cochrane evidence based reviews: iritis

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Genetic Tests for Iritis

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Anatomical Context for Iritis

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MalaCards organs/tissues related to Iritis:

41
Eye, Retina, Testes, Endothelial, Skin, Brain, Lung
Sources

Publications for Iritis

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Articles related to Iritis:

(show top 50) (show all 1248)
# Title Authors PMID Year
1
Known and novel ocular toxicities of biologics, targeted agents, and traditional chemotherapeutics. 38
31098752 2019
2
West Indies Glaucoma Laser Study (WIGLS) 3. Anterior Chamber Inflammation Following Selective Laser Trabeculoplasty in Afro-Caribbeans with Open-angle Glaucoma. 38
30921277 2019
3
Cost and Visit Duration of Same-Day Access at an Academic Ophthalmology Department vs Emergency Department. 38
31021382 2019
4
Selective laser trabeculoplasty in exfoliative glaucoma eyes with prior argon laser trabeculoplasty. 38
31091010 2019
5
Clinical features of anterior uveitis caused by three different herpes viruses. 38
31134426 2019
6
Calcified mucinous adenocarcinoma of the stomach metastatic to the iris: a case report. 38
30841908 2019
7
Frontal fibrosing alopecia demographics: a survey of 29 patients. 38
30893399 2019
8
The Impact of Inflammatory Bowel Disease in Canada 2018: Extra-intestinal Diseases in IBD. 38
31294387 2019
9
Evaluation of the etiology of persistent iritis after cataract surgery. 38
30778743 2019
10
Comparative analysis of retropupillary iris claw versus scleral-fixated intraocular lens in the management of post-cataract aphakia. 38
30574894 2019
11
Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients. 38
30403300 2018
12
Safety of IBI-10090 for inflammation associated with cataract surgery: Phase 3 multicenter study. 38
30139638 2018
13
Effectiveness of real-time PCR for diagnosis and prognosis of varicella-zoster virus keratitis. 38
29948430 2018
14
Herpes Zoster Optic Neuropathy. 38
29266031 2018
15
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. 38
29801472 2018
16
Extraintestinal Manifestations in Vedolizumab and Anti-TNF-Treated Patients With Inflammatory Bowel Disease. 38
29668916 2018
17
Cyclodestructive procedures for non-refractory glaucoma. 38
29694684 2018
18
Visually Significant Cystoid Macula Edema After Glaucoma Drainage Implant Surgery. 38
29271812 2018
19
[Candida infiltrations in the iris and lens during iritis and situation after sepsis]. 38
28144736 2018
20
Medical Malpractice in Uveitis: A Review of Clinical Entities and Outcomes. 38
27715388 2018
21
Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. 38
29670780 2018
22
The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science. 38
30505307 2018
23
Assessment, care and management of patients with red eye. 38
29210535 2017
24
[The clinical analysis of corneal interface fluid syndrome after Laser lamellar corneal refractive surgery]. 38
29141390 2017
25
Birdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset. 38
27070723 2017
26
Long-term safety and efficacy of ziv-aflibercept in retinal diseases. 38
28270485 2017
27
Safety and effectiveness of gold glaucoma micro shunt for reducing intraocular pressure in Japanese patients with open angle glaucoma. 38
28600745 2017
28
Systemic Sarcoidosis with Thyroid Involvement. 38
28781308 2017
29
Reactions with Antisera and Pathological Effects of Staphylococcus aureus Gamma-Toxin in the Cornea. 38
28346009 2017
30
Ophthalmologic manifestations in patients with inflammatory bowel disease. 38
28670235 2017
31
Headache, TIA and subarachnoid haemorrhage: dissecting an unusual cause for stroke-like symptoms. 38
28705843 2017
32
The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. 38
28465249 2017
33
Single-pass four-throw technique for pupilloplasty. 38
28009401 2017
34
A Case of Rhegmatogenous Retinal Detachment at Late Stage following Endogenous Bacterial Endophthalmitis. 38
28690534 2017
35
Granulomatosis with polyangiitis: seeing the diagnosis. 38
28487300 2017
36
Practice patterns for herpes simplex keratitis: A survey of ophthalmologists in Gulf Coast countries. 38
28559714 2017
37
Leprosy reactions in postelimination stage: the Bangladesh experience. 38
27859670 2017
38
Efficacy of neodymium-doped yttrium aluminum garnet laser iridotomies in primary angle-closure diseases: superior peripheral iridotomy versus inferior peripheral iridotomy. 38
28035845 2017
39
Gender specific differences in patients with psoriatic arthritis. 38
27415964 2017
40
Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD). 38
26997338 2017
41
Refractive lens exchange in younger and older presbyopes: comparison of complication rates, 3 months clinical and patient-reported outcomes. 38
28894356 2017
42
The Spectrum of Uveitis in Southern Vietnam. 38
27726522 2017
43
Uveitis incidence in Jichi Medical University Hospital, Japan, during 2011-2015. 38
28670107 2017
44
[Iritis : What has glaucoma to do with it?] 38
27272635 2017
45
Recurrent Uveal Effusion after Laser Iridotomy. 38
28203193 2017
46
A case of keratitis associated with limbal relaxing incision. 38
28112139 2016
47
Ocular Jellyfish Stings: Report of 2 Cases and Literature Review. 38
27436284 2016
48
Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant. 38
26719491 2016
49
A Novel Technique of a Transcorneal Suture to Manage an Iris Tuck into the Tube of a Glaucoma Drainage Device. 38
27175991 2016
50
Don't Forget What You Can't See: A Case of Ocular Syphilis. 38
27429702 2016
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Variations for Iritis

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Expression for Iritis

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Search GEO for disease gene expression data for Iritis.
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Pathways for Iritis

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Pathways related to Iritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 10.82 TNFRSF1B CD40LG
2
Inflammatory Response Pathway 1
10.14 TNFRSF1B CD40LG
Sources

GO Terms for Iritis

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Biological processes related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 TNFRSF1B HLA-B CD40LG
2 tumor necrosis factor-mediated signaling pathway GO:0033209 8.96 TNFRSF1B CD40LG
3 inflammatory response GO:0006954 8.8 TNFRSF1B PLA2G2D CD40LG
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Sources for Iritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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