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MCID: IRT001
MIFTS: 35

Iritis

Categories: Eye diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Iritis

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MalaCards integrated aliases for Iritis:

Name: Iritis 12 77 45 15 17 74

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1406
MeSH 45 D007500
NCIt 51 C50621
SNOMED-CT 69 65074000
UMLS 74 C0022081
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Summaries for Iritis

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MalaCards based summary : Iritis is related to spondylitis and spondyloarthropathy 1. An important gene associated with Iritis is MRAP (Melanocortin 2 Receptor Accessory Protein). The drugs Infliximab and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and skin, and related phenotype is Increased shRNA abundance.

Wikipedia : 77 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

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Related Diseases for Iritis

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Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 spondylitis 30.7 HLA-B TNFRSF1B
2 spondyloarthropathy 1 30.2 HLA-B MRAP TNFRSF1B
3 iridocyclitis 30.2 HLA-B MRAP
4 enthesopathy 29.8 MRAP PHB2
5 behcet syndrome 29.7 HLA-B MRAP TNFRSF1B
6 vasculitis 29.3 HLA-B TNFRSF1B
7 bone inflammation disease 29.1 MRAP PHB2 TNFRSF1B
8 norrie disease 11.3
9 severe cutaneous adverse reaction 11.2
10 endotheliitis 11.2
11 arthritis 10.3
12 cataract 10.2
13 herpes simplex 10.2
14 toxic optic neuropathy 10.2 EPO MRAP
15 hypopyon 10.2
16 uveitis 10.1
17 syphilis 10.1
18 conjunctivitis 10.1
19 glaucomatocyclitic crisis 10.1 HLA-B MRAP
20 scleral disease 10.1 MRAP TNFRSF1B
21 pustulosis of palm and sole 10.1 MRAP TNFRSF1B
22 tenosynovitis 10.0 MRAP TNFRSF1B
23 rheumatoid arthritis 10.0
24 colitis 10.0
25 diabetic autonomic neuropathy 10.0
26 autonomic neuropathy 10.0
27 retinitis 10.0
28 juvenile rheumatoid arthritis 10.0
29 herpes zoster 10.0
30 neuropathy 10.0
31 herpes zoster ophthalmicus 10.0
32 orbital plasma cell granuloma 10.0 MRAP TNFRSF1B
33 inclusion conjunctivitis 10.0 MRAP PSEN2
34 chronic orbital inflammation 10.0 MRAP TNFRSF1B
35 acute salpingitis 10.0 MRAP TNFRSF1B
36 conjunctival disease 10.0 MRAP PSEN2
37 anterior scleritis 10.0 MRAP TNFRSF1B
38 acquired immunodeficiency syndrome 10.0 EPO HLA-B
39 bladder cancer 10.0
40 keratitis, hereditary 10.0
41 blau syndrome 10.0
42 hepatitis 10.0
43 ulcerative colitis 10.0
44 optic papillitis 10.0
45 myopia 10.0
46 melanoma 10.0
47 meningitis 10.0
48 refractive error 10.0
49 anterior uveitis 10.0
50 stromal keratitis 10.0

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis
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Symptoms & Phenotypes for Iritis

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GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CNOT1 EPO HLA-B
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Drugs & Therapeutics for Iritis

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Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Dermatologic Agents Phase 4
4 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Not Applicable
5 valacyclovir Phase 4
6 Antiviral Agents Phase 4,Phase 2
7 Anti-Infective Agents Phase 4,Phase 2
8
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
9
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
10
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
11
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
12
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
13
Difluprednate Approved Phase 3,Phase 2 23674-86-4 443936
14
Fluprednisolone Approved Phase 3,Phase 2 53-34-9
15
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
16
Azathioprine Approved Phase 3 446-86-6 2265
17
carbamide peroxide Approved Phase 3 124-43-6
18
Prednisolone hemisuccinate Experimental Phase 3,Phase 2 2920-86-7
19 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Not Applicable
20 Protective Agents Phase 3,Phase 2
21 Prednisolone acetate Phase 3,Phase 2
22 glucocorticoids Phase 3,Phase 2,Not Applicable
23 Neuroprotective Agents Phase 3,Phase 2
24 Hormones Phase 3,Phase 2,Not Applicable
25 Hormone Antagonists Phase 3,Phase 2,Not Applicable
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
27 Antiemetics Phase 3,Phase 2,Not Applicable
28 Methylprednisolone Acetate Phase 3,Phase 2
29 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
31 Autonomic Agents Phase 3,Phase 2,Not Applicable
32 Antimetabolites Phase 3,Phase 2
33 Liver Extracts Phase 3
34 alanine Phase 3
35 Immunologic Factors Phase 3,Phase 2
36 Immunosuppressive Agents Phase 3,Phase 2
37 Aspartic Acid Phase 3
38 N-Methylaspartate Phase 3
39 Antimetabolites, Antineoplastic Phase 3,Phase 2
40
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
41
Ranibizumab Approved Phase 2 347396-82-1 459903
42
Talimogene laherparepvec Approved, Experimental, Investigational Phase 1, Phase 2 1187560-31-1
43
Ipilimumab Approved Phase 1, Phase 2 477202-00-9
44
Pembrolizumab Approved Phase 2 1374853-91-4
45
Gemcitabine Approved Phase 2 95058-81-4 60750
46
Bromfenac Approved July 1997 Phase 2 91714-94-2 60726
47 Triamcinolone hexacetonide Phase 2
48 Triamcinolone diacetate Phase 2
49 triamcinolone acetonide Phase 2
50 Analgesics Phase 2,Not Applicable

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
3 Zoster Eye Disease Study Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
4 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
5 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
6 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
7 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2 Euphrasia;Prednisolone acetate
8 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
9 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
10 Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration Completed NCT00805233 Phase 2 combination ranibizumab + bromfenac;ranibizumab injection alone
11 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
12 Trial to Evaluate Efficacy and Safety of Pembrolizumab and Gemcitabine in HER2-negative ABC Active, not recruiting NCT03025880 Phase 2 Pembrolizumab;Gemcitabine
13 Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease Terminated NCT00584740 Phase 2 AIN457;Placebo
14 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1 Chicken type II collagen
15 Safety Study of Latanoprost Slow Release Insert Terminated NCT01180062 Phase 1 Latanoprost;Arm 2;Latanoprost SR insert
16 Safety and Surgical Performance Study of Aurosleek Surgical Blades Unknown status NCT01763593
17 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010 Not Applicable
18 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
19 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593 Not Applicable Diclofenac;Dexamethasone
20 Screening for NEI Clinical Studies Completed NCT00001734
21 Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases Completed NCT03206983 Not Applicable
22 To Evaluate Eye Installation-Tear Free Completed NCT02802917 Not Applicable SPF 50 Y49 091 (BAY 987516);SPF 50 X15 158 (BAY 987516);SPF 50 X15 160 (BAY 987516);SPF 50 X57 162 (BAY 987516)
23 Effect of Intra-subject Phaco/Trabectome vs. Phaco/Kahook Dual Blade on Intraocular Pressure Recruiting NCT03894631 Not Applicable

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: iritis

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Genetic Tests for Iritis

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Anatomical Context for Iritis

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MalaCards organs/tissues related to Iritis:

42
Eye, Retina, Skin, Endothelial, Liver, Bone, Testes
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Publications for Iritis

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Articles related to Iritis:

(show top 50) (show all 272)
# Title Authors Year
1
Evaluation of the etiology of persistent iritis after cataract surgery. ( 30778743 )
2019
2
Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant. ( 26719491 )
2016
3
Corneal Endothelial Cell Loss and Iritis Associated With a New Cosmetic Iris Implant. ( 25811391 )
2015
4
Intravitreal aflibercept after bilateral bevacizumab-induced iritis. ( 25871873 )
2015
5
Chronic iritis associated with cutaneous leukocytoclastic vasculitis. ( 25939124 )
2015
6
Free-Floating Iris Cyst in a Patient with Recurrent Iritis. ( 26120316 )
2015
7
Bilateral Iritis after Vaccine for Bladder Cancer. ( 26258277 )
2015
8
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. ( 24417640 )
2014
9
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. ( 24135297 )
2013
10
Visante OCT in the diagnosis of caterpillar-induced iritis. ( 23931492 )
2013
11
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. ( 23089088 )
2012
12
Restrictive (Mechanical) Strabismus: An Epidemic? DNA or Not, Twins Faces, Texas, DRS, Iritis Monitoring. ( 22747761 )
2012
13
Lay Person Slit Lamp Detection of Iritis in Absence of an Eye MD: Test of a Portable Model of Cells and Flare. ( 22747766 )
2012
14
Iritis and pupillary distortion after periorbital cosmetic alexandrite laser. ( 21057804 )
2011
15
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. ( 21573094 )
2011
16
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. ( 22205833 )
2011
17
Iritis, ptosis, and sequential severe loss of vision in a patient with essential thrombocytosis. ( 19696799 )
2010
18
Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success. ( 20581051 )
2010
19
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. ( 19606176 )
2009
20
Severe iritis and choroidal effusion following selective laser trabeculoplasty. ( 18831426 )
2008
21
Hypopyon iritis after primary fresh amniotic membrane transplantation. ( 18043192 )
2007
22
Bilateral ankle edema with bilateral iritis. ( 16633708 )
2007
23
Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. ( 17964410 )
2007
24
Latanoprost induced iritis after vitrectomy surgery. ( 25390234 )
2007
25
Iritis presumed as secondary to disseminated coccidioidomycosis. ( 17145566 )
2006
26
Intravitreal ganciclovir injections in aqueous cytomegalovirus DNA positive hypertensive iritis. ( 16200055 )
2006
27
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. ( 16751847 )
2006
28
Recurrent iritis after implantation of an iris-fixated phakic intraocular lens for the correction of myopia Case report and clinicopathologic correlation. ( 16863980 )
2006
29
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. Does a normal-shaped pupil exclude the diagnosis of iritis. ( 17057143 )
2006
30
Central serous chorioretinopathy associated with periocular corticosteroid injection treatment for HLA-B27-associated iritis. ( 15197074 )
2004
31
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. ( 15327114 )
2004
32
Effect of etanercept on iritis in patients with ankylosing spondylitis. ( 15529379 )
2004
33
The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis. ( 12966615 )
2003
34
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. ( 12027105 )
2002
35
Pouchitis-associated iritis (uveitis) following total proctocolectomy and ileal pouch-to-anal anastomosis in ulcerative colitis. ( 11240384 )
2001
36
Diffuse lamellar keratitis associated with iritis 10 months after laser in situ keratomileusis. ( 11489588 )
2001
37
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. ( 11899428 )
2001
38
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. ( 19078446 )
2000
39
Iritis associated with Sweet's syndrome. ( 10971503 )
2000
40
Intravenous cidofovir-induced iritis. ( 10028099 )
1999
41
Iritis associated with intravenous cidofovir. ( 10084411 )
1999
42
Low-dose methotrexate in the treatment of severe juvenile rheumatoid arthritis and sarcoid iritis. ( 10358815 )
1999
43
Expression of stress-response protein 60 in iritis associated with experimental autoimmune encephalomyelitis. ( 10672873 )
1999
44
Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. ( 9508240 )
1998
45
Prevention of herpes simplex keratitis and iritis. ( 9488290 )
1998
46
Cataract surgery in a patient with severe chronic iritis and corneal endothelial damage. ( 9682104 )
1998
47
Cytomegalovirus iritis. ( 9824866 )
1998
48
Sensorineural hearing loss, iritis and ankylosing spondylitis. ( 9973173 )
1998
49
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. ( 9194724 )
1997
50
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. ( 9194719 )
1997
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Variations for Iritis

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Expression for Iritis

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Search GEO for disease gene expression data for Iritis.
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Pathways for Iritis

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GO Terms for Iritis

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Biological processes related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 8.62 CNOT1 PHB2

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.56 CNOT1 EPO HLA-B MRAP PHB2 PSEN2
2 estrogen receptor binding GO:0030331 8.62 CNOT1 PHB2
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Sources for Iritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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