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MCID: IRT001
MIFTS: 43

Iritis

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Iritis

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MalaCards integrated aliases for Iritis:

Name: Iritis 12 74 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1406
MeSH 43 D007500
NCIt 49 C50621
SNOMED-CT 67 65074000
UMLS 71 C0022081
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Summaries for Iritis

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MalaCards based summary : Iritis is related to severe cutaneous adverse reaction and spondyloarthropathy 1. An important gene associated with Iritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs valacyclovir and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

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Related Diseases for Iritis

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Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 673)
# Related Disease Score Top Affiliating Genes
1 severe cutaneous adverse reaction 31.4 TNFRSF1B TNF HLA-B CRP CD40LG CD4
2 spondyloarthropathy 1 31.1 TNFRSF1B TNF NOD2 MRAP HLA-B ERAP1
3 cytomegalovirus retinitis 30.5 TNF HLA-B CD4
4 conjunctivitis 30.5 TNF IL6 HLA-B
5 interstitial nephritis 30.4 CRP CD40LG ACE
6 keratitis, hereditary 30.3 TNF IL6 CD4 CCR6
7 poliomyelitis 30.3 TNF CD40LG CD4
8 latent syphilis 30.3 CD40LG CD4
9 uveitis 30.2 TNFRSF1B TNF NOD2 IL6 HLA-B
10 coccidioidomycosis 30.2 CD40LG CD4 CCR6
11 vitiligo-associated multiple autoimmune disease susceptibility 1 30.1 HLA-B CD4 CCR6
12 spondyloarthropathy 30.1 TNF IL6 HLA-B
13 pustulosis of palm and sole 30.1 TNFRSF1B TNF MRAP CCR6
14 juvenile rheumatoid arthritis 30.0 TNFRSF1B TNF IL6 CRP
15 neuroretinitis 30.0 MRAP CRP CD40LG CD4 ACE
16 arthropathy 29.9 TNF IL6 HLA-B CRP
17 mumps 29.9 TNFRSF1B TNF IL6 CD40LG
18 chlamydia 29.9 TNF IL6 CRP CD40LG
19 cysticercosis 29.8 IL6 CD40LG CD4
20 brucellosis 29.8 TNF IL6 CRP CD40LG
21 hypopyon 29.8 TNFRSF1B MRAP IL6 HLA-B CRP CD4
22 syphilis 29.8 MRAP CRP CD40LG CD4 CCR6 ACE
23 colitis 29.8 TNF NOD2 IL6 CCR6
24 thrombocytosis 29.8 IL6 EPO CRP
25 enthesopathy 29.8 TNFRSF1B TNF MRAP ERAP1 CRP CCR6
26 meningitis 29.7 TNF IL6 HLA-B CRP CD40LG
27 scleritis 29.7 TNFRSF1B TNF MRAP CRP CCR6
28 typhoid fever 29.7 TNF IL6 CRP CD40LG CCR6
29 reactive arthritis 29.6 TNF IL6 HLA-B CRP CCR6
30 herpes zoster 29.6 TNFRSF1B TNF HLA-B CRP CD40LG CD4
31 intestinal perforation 29.6 NOD2 IL6 CRP
32 lipid storage disease 29.6 TNF IL6 CCR6
33 endophthalmitis 29.6 TNF MRAP IL6 CRP CD4
34 endocarditis 29.6 TNFRSF1B TNF IL6 CRP
35 lyme disease 29.6 TNF IL6 CRP CD40LG
36 rheumatic fever 29.6 TNF IL6 CD40LG ACE
37 salmonellosis 29.6 TNF IL6 CD4 CCR6
38 rheumatic disease 29.6 TNFRSF1B TNF HLA-B ERAP1 CRP CD40LG
39 choroiditis 29.5 TNF MRAP CD40LG CD4 ACE
40 dermatitis 29.4 TNF NOD2 IL6 CCR6
41 optic papillitis 29.4 TNFRSF1B MRAP CRP CD40LG CD4 ACE
42 chlamydia pneumonia 29.4 TNF IL6 CRP CD40LG CD4
43 macular retinal edema 29.4 TNFRSF1B TNF MRAP IL6 ACE
44 essential thrombocythemia 29.3 TNF IL6 EPO CRP CD40LG
45 vasculitis 29.3 TNFRSF1B TNF IL6 HLA-B CRP CD40LG
46 ulcerative colitis 29.3 TNF NOD2 IL6 CRP CCR6
47 pericarditis 29.2 TNF IL6 CRP CD40LG ACE
48 spondylitis 29.1 TNFRSF1B TNF NOD2 IL6 HLA-B ERAP1
49 iridocyclitis 29.1 TNFRSF1B TNF MRAP IL6 HLA-B CRP
50 chickenpox 29.0 TNFRSF1B TNF IL6 CRP CD40LG CD4

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis
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Symptoms & Phenotypes for Iritis

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MGI Mouse Phenotypes related to Iritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ACE CCR6 CD4 CD40LG EPO ERAP1
2 homeostasis/metabolism MP:0005376 9.73 ACE CCR6 CD4 CD40LG CRP EPO
3 immune system MP:0005387 9.4 ACE CCR6 CD4 CD40LG CRP EPO
Sources

Drugs & Therapeutics for Iritis

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Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 valacyclovir Phase 4
2 Antiviral Agents Phase 4
3
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
4
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
5
Acetazolamide Approved, Vet_approved Phase 2, Phase 3 59-66-5 1986
6
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
7
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
8
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
9
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
10
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
11 Anti-Inflammatory Agents Phase 2, Phase 3
12 Analgesics Phase 2, Phase 3
13 Analgesics, Non-Narcotic Phase 2, Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
15 Cyclooxygenase Inhibitors Phase 2, Phase 3
16 Antirheumatic Agents Phase 2, Phase 3
17 Central Nervous System Depressants Phase 2, Phase 3
18 Fibrinolytic Agents Phase 2, Phase 3
19 Narcotics Phase 2, Phase 3
20 Respiratory System Agents Phase 2, Phase 3
21 Platelet Aggregation Inhibitors Phase 2, Phase 3
22 Antipyretics Phase 2, Phase 3
23 Natriuretic Agents Phase 2, Phase 3
24 Analgesics, Opioid Phase 2, Phase 3
25 Antitussive Agents Phase 2, Phase 3
26 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
27 Anticonvulsants Phase 2, Phase 3
28 Carbonic Anhydrase Inhibitors Phase 2, Phase 3
29 diuretics Phase 2, Phase 3
30
Difluprednate Approved Phase 2 23674-86-4 443936
31
Fluprednisolone Approved Phase 2 53-34-9
32
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
33 Triamcinolone hexacetonide Phase 2
34 triamcinolone acetonide Phase 2
35 Triamcinolone diacetate Phase 2
36 Immunosuppressive Agents Phase 2
37 Immunologic Factors Phase 2
38
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
39
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
40
Diclofenac Approved, Vet_approved 15307-86-5 3033
41
Lactitol Investigational 585-86-4, 585-88-6 493591
42 Polymethyl Methacrylate
43 Cathartics
44 HIV Protease Inhibitors
45
protease inhibitors
46 Laxatives
47 Pharmaceutical Solutions
48 Ophthalmic Solutions
49 BB 1101
50 Dexamethasone 21-phosphate

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
2 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
3 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
4 Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Inluding Iritis, Cyclitis, Iridocyclitis, and Panuveitis). Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
5 Treatment of Active Anterior Uveitis Associated With JIA, Using Humanized Anti-Tac (HAT, Daclizumab) Completed NCT00130637 Phase 2 Daclizumab
6 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1 Chicken type II collagen
7 Postoperative Events in Patients With and Without Retained Nuclear Fragments in the Anterior Vitreous After Routine Phacoemulsification Unknown status NCT02058394
8 EyeKon Medical, Inc. Capsular Tension Ring Clinical Study Unknown status NCT02332369
9 PEMF an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
10 Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Ocular Inflammatory or Immunologic Diseases Completed NCT00001734
11 Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function. Completed NCT00476593 Diclofenac;Dexamethasone
12 Evaluation and Treatment Protocol for Patients With Intraocular Inflammatory Disease (Uveitis) Completed NCT00006188
13 Evaluation of the Acrysof Toric SN60T3 Intraocular Lens in Patients With Predicted Residual Corneal Astigmatism Between 0.75 and 1.00 D. Completed NCT00542581
14 Connection Between Periodontitis and Exudative Age-related Macular Degeneration Not yet recruiting NCT03958461
15 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Withdrawn NCT02416128 Euphrasia;Prednisolone acetate

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Loteprednol
loteprednol etabonate
Tropicamide

Cochrane evidence based reviews: iritis

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Genetic Tests for Iritis

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Anatomical Context for Iritis

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MalaCards organs/tissues related to Iritis:

40
Eye, Skin, Retina, Lung, Bone, Heart, Kidney
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Publications for Iritis

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Articles related to Iritis:

(show top 50) (show all 1251)
# Title Authors PMID Year
1
Selective laser trabeculoplasty in exfoliative glaucoma eyes with prior argon laser trabeculoplasty. 61
31091010 2020
2
Clinical features of anterior uveitis caused by three different herpes viruses. 61
31134426 2019
3
The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: a review of the literature. 61
31485882 2019
4
Epidemiology of Adult Uveitis in a Northern Ireland Tertiary Referral Centre. 61
31619852 2019
5
Known and novel ocular toxicities of biologics, targeted agents, and traditional chemotherapeutics. 61
31098752 2019
6
West Indies Glaucoma Laser Study (WIGLS) 3. Anterior Chamber Inflammation Following Selective Laser Trabeculoplasty in Afro-Caribbeans with Open-angle Glaucoma. 61
30921277 2019
7
Cost and Visit Duration of Same-Day Access at an Academic Ophthalmology Department vs Emergency Department. 61
31021382 2019
8
Calcified mucinous adenocarcinoma of the stomach metastatic to the iris: a case report. 61
30841908 2019
9
The Impact of Inflammatory Bowel Disease in Canada 2018: Extra-intestinal Diseases in IBD. 61
31294387 2019
10
Frontal fibrosing alopecia demographics: a survey of 29 patients. 61
30893399 2019
11
Evaluation of the etiology of persistent iritis after cataract surgery. 61
30778743 2019
12
A Case of Unilateral Coccidioidal Chorioretinitis in a Patient with HIV-Associated Meningoencephalitis. 61
31687242 2019
13
Comparative analysis of retropupillary iris claw versus scleral-fixated intraocular lens in the management of post-cataract aphakia. 61
30574894 2019
14
Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients. 61
30403300 2018
15
Safety of IBI-10090 for inflammation associated with cataract surgery: Phase 3 multicenter study. 61
30139638 2018
16
Extraintestinal Manifestations in Vedolizumab and Anti-TNF-Treated Patients With Inflammatory Bowel Disease. 61
29668916 2018
17
Effectiveness of real-time PCR for diagnosis and prognosis of varicella-zoster virus keratitis. 61
29948430 2018
18
Herpes Zoster Optic Neuropathy. 61
29266031 2018
19
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. 61
29801472 2018
20
Cyclodestructive procedures for non-refractory glaucoma. 61
29694684 2018
21
Visually Significant Cystoid Macula Edema After Glaucoma Drainage Implant Surgery. 61
29271812 2018
22
[Candida infiltrations in the iris and lens during iritis and situation after sepsis]. 61
28144736 2018
23
Medical Malpractice in Uveitis: A Review of Clinical Entities and Outcomes. 61
27715388 2018
24
Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. 61
29670780 2018
25
The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science. 61
30505307 2018
26
Assessment, care and management of patients with red eye. 61
29210535 2017
27
[The clinical analysis of corneal interface fluid syndrome after Laser lamellar corneal refractive surgery]. 61
29141390 2017
28
Birdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset. 61
27070723 2017
29
Long-term safety and efficacy of ziv-aflibercept in retinal diseases. 61
28270485 2017
30
Safety and effectiveness of gold glaucoma micro shunt for reducing intraocular pressure in Japanese patients with open angle glaucoma. 61
28600745 2017
31
Systemic Sarcoidosis with Thyroid Involvement. 61
28781308 2017
32
Reactions with Antisera and Pathological Effects of Staphylococcus aureus Gamma-Toxin in the Cornea. 61
28346009 2017
33
Ophthalmologic manifestations in patients with inflammatory bowel disease. 61
28670235 2017
34
Headache, TIA and subarachnoid haemorrhage: dissecting an unusual cause for stroke-like symptoms. 61
28705843 2017
35
The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases. 61
28465249 2017
36
Single-pass four-throw technique for pupilloplasty. 61
28009401 2017
37
A Case of Rhegmatogenous Retinal Detachment at Late Stage following Endogenous Bacterial Endophthalmitis. 61
28690534 2017
38
Granulomatosis with polyangiitis: seeing the diagnosis. 61
28487300 2017
39
Practice patterns for herpes simplex keratitis: A survey of ophthalmologists in Gulf Coast countries. 61
28559714 2017
40
Leprosy reactions in postelimination stage: the Bangladesh experience. 61
27859670 2017
41
Efficacy of neodymium-doped yttrium aluminum garnet laser iridotomies in primary angle-closure diseases: superior peripheral iridotomy versus inferior peripheral iridotomy. 61
28035845 2017
42
Gender specific differences in patients with psoriatic arthritis. 61
27415964 2017
43
Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD). 61
26997338 2017
44
Refractive lens exchange in younger and older presbyopes: comparison of complication rates, 3 months clinical and patient-reported outcomes. 61
28894356 2017
45
The Spectrum of Uveitis in Southern Vietnam. 61
27726522 2017
46
Uveitis incidence in Jichi Medical University Hospital, Japan, during 2011-2015. 61
28670107 2017
47
[Iritis : What has glaucoma to do with it?] 61
27272635 2017
48
Recurrent Uveal Effusion after Laser Iridotomy. 61
28203193 2017
49
A case of keratitis associated with limbal relaxing incision. 61
28112139 2016
50
Ocular Jellyfish Stings: Report of 2 Cases and Literature Review. 61
27436284 2016
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Variations for Iritis

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Expression for Iritis

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Search GEO for disease gene expression data for Iritis.
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Pathways for Iritis

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Pathways related to Iritis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.13 TNFRSF1B TNF NOD2 IL6 HLA-B CD40LG
2
PAK Pathway 63
Show member pathways
 13.04 TNFRSF1B TNF PLA2G2D IL6 CD40LG CD4
3
Allograft rejection 1 36
Show member pathways
 12.69 TNF IL6 HLA-B CD40LG CD4
4
Human T-cell leukemia virus 1 infection 36
12.15 TNF IL6 HLA-B CD4
5
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.13 TNFRSF1B TNF IL6 CCR6
6
Innate Lymphoid Cell Differentiation Pathways 64
11.64 TNF CD4 CCR6
7
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 TNF IL6 EPO CD4
8
Dendritic Cells Developmental Lineage Pathway 64
11.58 TNF IL6 CD4
9
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.56 TNFRSF1B TNF CD40LG
10
TNF signaling pathway 36
11.51 TNFRSF1B TNF NOD2 IL6
11
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.43 TNF IL6 CD40LG
12
Malaria 36
11.28 TNF IL6 CD40LG
13
Hematopoietic cell lineage 36
11.25 TNF IL6 EPO CD4
14
Interleukin-10 signaling 65
11.23 TNFRSF1B TNF IL6
15
Cytokines and Inflammatory Response 1
10.96 TNF IL6 CD4
16
Overview of nanoparticle effects 1
10.08 TNF IL6 CRP
Sources

GO Terms for Iritis

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Cellular components related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 TNF IL6 HLA-B ERAP1 EPO CRP
2 extracellular region GO:0005576 9.81 TNFRSF1B TNF PLA2G2D IL6 ERAP1 EPO
3 external side of plasma membrane GO:0009897 9.43 TNF HLA-B CD40LG CD4 CCR6 ACE
4 cell surface GO:0009986 9.17 TNF NOD2 HLA-B EPO CD40LG CD4

Biological processes related to Iritis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 TNFRSF1B TNF IL6 CD4
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 TNF NOD2 EPO CD4
3 cellular response to lipopolysaccharide GO:0071222 9.73 TNFRSF1B TNF NOD2 IL6
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 TNF IL6 EPO
5 positive regulation of T cell proliferation GO:0042102 9.69 IL6 CD40LG CD4
6 positive regulation of interleukin-6 production GO:0032755 9.67 TNF NOD2 IL6
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 TNF NOD2 IL6 CD40LG
8 positive regulation of protein kinase activity GO:0045860 9.65 TNF EPO CD4
9 humoral immune response GO:0006959 9.63 TNF IL6 CCR6
10 inflammatory response GO:0006954 9.63 TNFRSF1B TNF PLA2G2D IL6 CRP CD40LG
11 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6
12 regulation of neuroinflammatory response GO:0150077 9.57 TNFRSF1B IL6
13 response to salt stress GO:0009651 9.56 TNF EPO
14 neutrophil mediated immunity GO:0002446 9.54 IL6 ACE
15 acute-phase response GO:0006953 9.5 IL6 EPO CRP
16 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 HLA-B ERAP1 ACE
17 regulation of immunoglobulin secretion GO:0051023 9.4 TNF CD40LG
18 immune response GO:0006955 9.17 TNFRSF1B TNF IL6 HLA-B CD40LG CD4
19 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 EPO CD40LG
2 interleukin-6 receptor binding GO:0005138 8.62 IL6 ERAP1
Sources

Sources for Iritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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