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MCID: IRT001
MIFTS: 34

Iritis

Categories: Eye diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Iritis

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MalaCards integrated aliases for Iritis:

Name: Iritis 12 76 44 15 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1406
MeSH 44 D007500
NCIt 50 C50621
SNOMED-CT 68 65074000
UMLS 73 C0022081
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Summaries for Iritis

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MalaCards based summary : Iritis is related to spondylitis and spondyloarthropathy 1. An important gene associated with Iritis is HLA-B (Major Histocompatibility Complex, Class I, B). The drugs Infliximab and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related phenotype is Increased shRNA abundance.

Wikipedia : 76 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

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Related Diseases for Iritis

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Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 spondylitis 30.6 HLA-B TNFRSF1B
2 spondyloarthropathy 1 30.3 HLA-B MRAP TNFRSF1B
3 iridocyclitis 30.1 HLA-B MRAP
4 vasculitis 29.4 HLA-B TNFRSF1B
5 norrie disease 11.3
6 severe cutaneous adverse reaction 11.1
7 endotheliitis 11.1
8 arthritis 10.3
9 herpes simplex 10.2
10 cataract 10.2
11 spondyloarthropathy 10.2 HLA-B MRAP
12 toxic optic neuropathy 10.1 EPO MRAP
13 hypopyon 10.1
14 pure red-cell aplasia 10.1 EPO HLA-B
15 scleral disease 10.1 MRAP TNFRSF1B
16 pustulosis of palm and sole 10.1 MRAP TNFRSF1B
17 uveitis 10.1
18 syphilis 10.1
19 conjunctivitis 10.1
20 tenosynovitis 10.1 MRAP TNFRSF1B
21 orbital plasma cell granuloma 10.1 MRAP TNFRSF1B
22 glaucomatocyclitic crisis 10.1 HLA-B MRAP
23 chronic orbital inflammation 10.0 MRAP TNFRSF1B
24 acute salpingitis 10.0 MRAP TNFRSF1B
25 anterior scleritis 10.0 MRAP TNFRSF1B
26 rheumatoid arthritis 10.0
27 colitis 10.0
28 diabetic autonomic neuropathy 10.0
29 autonomic neuropathy 10.0
30 retinitis 10.0
31 juvenile rheumatoid arthritis 10.0
32 herpes zoster 10.0
33 neuropathy 10.0
34 herpes zoster ophthalmicus 10.0
35 inclusion conjunctivitis 10.0 MRAP PSEN2
36 conjunctival disease 10.0 MRAP PSEN2
37 acquired immunodeficiency syndrome 10.0 EPO HLA-B
38 balanitis 10.0 MRAP PHB2
39 hypersensitivity reaction type iv disease 10.0 MRAP TNFRSF1B
40 panuveitis 10.0 HLA-B MRAP TNFRSF1B
41 uveal disease 10.0 HLA-B MRAP TNFRSF1B
42 enthesopathy 10.0 MRAP PHB2
43 bursitis 9.9 MRAP PHB2
44 behcet syndrome 9.9 HLA-B MRAP TNFRSF1B
45 palindromic rheumatism 9.9 MRAP TNFRSF1B
46 urethritis 9.9 MRAP PHB2
47 aplastic anemia 9.9 EPO HLA-B SRP72
48 tendinitis 9.9 MRAP PHB2
49 bladder cancer 9.9
50 blau syndrome 9.9

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis
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Symptoms & Phenotypes for Iritis

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GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CNOT1 EPO HLA-B
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Drugs & Therapeutics for Iritis

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Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2
Acyclovir Approved Phase 4 59277-89-3 2022
3 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Dermatologic Agents Phase 4
5 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Not Applicable
6 Anti-Infective Agents Phase 4,Phase 2
7 valacyclovir Phase 4
8 Antiviral Agents Phase 4,Phase 2
9
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
10
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
11
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
12
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
13
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
14
Fluprednisolone Approved Phase 3,Phase 2 53-34-9
15
Difluprednate Approved Phase 3,Phase 2 23674-86-4 443936
16
Azathioprine Approved Phase 3 446-86-6 2265
17
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
18
Prednisolone hemisuccinate Experimental Phase 3,Phase 2 2920-86-7
19 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Not Applicable
20 Hormone Antagonists Phase 3,Phase 2,Not Applicable
21 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
22 Prednisolone acetate Phase 3,Phase 2
23 Methylprednisolone acetate Phase 3,Phase 2
24 Autonomic Agents Phase 3,Phase 2,Not Applicable
25 Neuroprotective Agents Phase 3,Phase 2
26 Protective Agents Phase 3,Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
28 Hormones Phase 3,Phase 2,Not Applicable
29 glucocorticoids Phase 3,Phase 2,Not Applicable
30 Antiemetics Phase 3,Phase 2,Not Applicable
31 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
32 Aspartic Acid Phase 3
33 alanine Phase 3
34 Immunologic Factors Phase 3,Phase 2,Phase 1
35 Liver Extracts Phase 3
36 N-Methylaspartate Phase 3
37 Immunosuppressive Agents Phase 3,Phase 2
38 Antimetabolites Phase 3,Phase 2
39 Antimetabolites, Antineoplastic Phase 3,Phase 2
40
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
41
Ranibizumab Approved Phase 2 347396-82-1 459903
42
Gemcitabine Approved Phase 2 95058-81-4 60750
43
Pembrolizumab Approved Phase 2 1374853-91-4
44
Bromfenac Approved July 1997 Phase 2 91714-94-2 60726
45 Triamcinolone diacetate Phase 2
46 Antibodies Phase 2,Phase 1
47 Immunoglobulin G Phase 2
48 Triamcinolone hexacetonide Phase 2
49 Immunoglobulins Phase 2,Phase 1
50 triamcinolone acetonide Phase 2

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
3 Zoster Eye Disease Study Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
4 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
5 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
6 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
7 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2 Euphrasia;Prednisolone acetate
8 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
9 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
10 Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration Completed NCT00805233 Phase 2 combination ranibizumab + bromfenac;ranibizumab injection alone
11 Trial to Evaluate Efficacy and Safety of Pembrolizumab and Gemcitabine in HER2-negative ABC Recruiting NCT03025880 Phase 2 Pembrolizumab;Gemcitabine
12 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
13 Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease Terminated NCT00584740 Phase 2 AIN457;Placebo
14 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1 Chicken type II collagen
15 Safety Study of Latanoprost Slow Release Insert Terminated NCT01180062 Phase 1 Latanoprost;Arm 2;Latanoprost SR insert
16 Safety and Surgical Performance Study of Aurosleek Surgical Blades Unknown status NCT01763593
17 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010 Not Applicable
18 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
19 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593 Not Applicable Diclofenac;Dexamethasone
20 Screening for NEI Clinical Studies Completed NCT00001734
21 Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases Completed NCT03206983 Not Applicable
22 To Evaluate Eye Installation-Tear Free Completed NCT02802917 Not Applicable SPF 50 Y49 091 (BAY 987516);SPF 50 X15 158 (BAY 987516);SPF 50 X15 160 (BAY 987516);SPF 50 X57 162 (BAY 987516)

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: iritis

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Genetic Tests for Iritis

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Anatomical Context for Iritis

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MalaCards organs/tissues related to Iritis:

41
Eye, Retina, Testes, Skin, Endothelial, Bone
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Publications for Iritis

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Articles related to Iritis:

(show top 50) (show all 272)
# Title Authors Year
1
Iritis ( 28613659 )
2017
2
Bilateral Iritis after Vaccine for Bladder Cancer. ( 26258277 )
2015
3
Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant. ( 26719491 )
2015
4
Intravitreal aflibercept after bilateral bevacizumab-induced iritis. ( 25871873 )
2015
5
Chronic iritis associated with cutaneous leukocytoclastic vasculitis. ( 25939124 )
2015
6
Corneal Endothelial Cell Loss and Iritis Associated With a New Cosmetic Iris Implant. ( 25811391 )
2015
7
Free-Floating Iris Cyst in a Patient with Recurrent Iritis. ( 26120316 )
2015
8
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. ( 24417640 )
2014
9
Visante OCT in the diagnosis of caterpillar-induced iritis. ( 23931492 )
2013
10
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. ( 24135297 )
2013
11
Restrictive (Mechanical) Strabismus: An Epidemic? DNA or Not, Twins Faces, Texas, DRS, Iritis Monitoring. ( 22747761 )
2012
12
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. ( 23089088 )
2012
13
Lay Person Slit Lamp Detection of Iritis in Absence of an Eye MD: Test of a Portable Model of Cells and Flare. ( 22747766 )
2012
14
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. ( 22205833 )
2011
15
Iritis and pupillary distortion after periorbital cosmetic alexandrite laser. ( 21057804 )
2011
16
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. ( 21573094 )
2011
17
Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success. ( 20581051 )
2010
18
Iritis, ptosis, and sequential severe loss of vision in a patient with essential thrombocytosis. ( 19696799 )
2010
19
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. ( 19606176 )
2009
20
Severe iritis and choroidal effusion following selective laser trabeculoplasty. ( 18831426 )
2008
21
Hypopyon iritis after primary fresh amniotic membrane transplantation. ( 18043192 )
2007
22
Latanoprost induced iritis after vitrectomy surgery. ( 25390234 )
2007
23
Bilateral ankle edema with bilateral iritis. ( 16633708 )
2007
24
Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. ( 17964410 )
2007
25
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. ( 16751847 )
2006
26
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. Does a normal-shaped pupil exclude the diagnosis of iritis. ( 17057143 )
2006
27
Intravitreal ganciclovir injections in aqueous cytomegalovirus DNA positive hypertensive iritis. ( 16200055 )
2006
28
Recurrent iritis after implantation of an iris-fixated phakic intraocular lens for the correction of myopia Case report and clinicopathologic correlation. ( 16863980 )
2006
29
Iritis presumed as secondary to disseminated coccidioidomycosis. ( 17145566 )
2006
30
Effect of etanercept on iritis in patients with ankylosing spondylitis. ( 15529379 )
2004
31
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. ( 15327114 )
2004
32
Central serous chorioretinopathy associated with periocular corticosteroid injection treatment for HLA-B27-associated iritis. ( 15197074 )
2004
33
The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis. ( 12966615 )
2003
34
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. ( 12027105 )
2002
35
Diffuse lamellar keratitis associated with iritis 10 months after laser in situ keratomileusis. ( 11489588 )
2001
36
Pouchitis-associated iritis (uveitis) following total proctocolectomy and ileal pouch-to-anal anastomosis in ulcerative colitis. ( 11240384 )
2001
37
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. ( 11899428 )
2001
38
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. ( 19078446 )
2000
39
Iritis associated with Sweet's syndrome. ( 10971503 )
2000
40
Low-dose methotrexate in the treatment of severe juvenile rheumatoid arthritis and sarcoid iritis. ( 10358815 )
1999
41
Expression of stress-response protein 60 in iritis associated with experimental autoimmune encephalomyelitis. ( 10672873 )
1999
42
Intravenous cidofovir-induced iritis. ( 10028099 )
1999
43
Iritis associated with intravenous cidofovir. ( 10084411 )
1999
44
Cytomegalovirus iritis. ( 9824866 )
1998
45
Prevention of herpes simplex keratitis and iritis. ( 9488290 )
1998
46
Cataract surgery in a patient with severe chronic iritis and corneal endothelial damage. ( 9682104 )
1998
47
Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. ( 9508240 )
1998
48
Sensorineural hearing loss, iritis and ankylosing spondylitis. ( 9973173 )
1998
49
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. ( 9194719 )
1997
50
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. ( 9194724 )
1997
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Variations for Iritis

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Expression for Iritis

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Search GEO for disease gene expression data for Iritis.
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Pathways for Iritis

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GO Terms for Iritis

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Biological processes related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 8.62 CNOT1 PHB2

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.56 CNOT1 EPO HLA-B MRAP PHB2 PSEN2
2 estrogen receptor binding GO:0030331 8.62 CNOT1 PHB2
Sources

Sources for Iritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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