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MCID: IRT001
MIFTS: 36

Iritis

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Iritis

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MalaCards integrated aliases for Iritis:

Name: Iritis 12 76 44 15 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1406
MeSH 44 D007500
NCIt 50 C50621
SNOMED-CT 68 65074000
UMLS 73 C0022081
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Summaries for Iritis

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MalaCards based summary : Iritis is related to spondylitis and iridocyclitis. An important gene associated with Iritis is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Inflammatory Response Pathway. The drugs Infliximab and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and liver, and related phenotype is Increased shRNA abundance.

Wikipedia : 76 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

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Related Diseases for Iritis

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Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 spondylitis 29.2 CD40LG HLA-B TNFRSF1B
2 iridocyclitis 29.1 CD40LG HLA-B MRAP
3 spondyloarthropathy 1 28.5 CD40LG HLA-B MRAP TNFRSF1B
4 endotheliitis 11.3
5 norrie disease 11.1
6 severe cutaneous adverse reaction 11.0
7 glaucomatocyclitic crisis 10.6 HLA-B MRAP
8 pure red-cell aplasia 10.5 EPO HLA-B
9 toxic optic neuropathy 10.5 EPO MRAP
10 spondyloarthropathy 10.4 HLA-B MRAP
11 balanitis 10.4 MRAP PHB2
12 enthesopathy 10.3 MRAP PHB2
13 bursitis 10.3 MRAP PHB2
14 tendinitis 10.3 MRAP PHB2
15 penile disease 10.3 MRAP PHB2
16 scleral disease 10.2 MRAP TNFRSF1B
17 pustulosis of palm and sole 10.2 MRAP TNFRSF1B
18 tenosynovitis 10.2 MRAP TNFRSF1B
19 orbital plasma cell granuloma 10.2 MRAP TNFRSF1B
20 chronic orbital inflammation 10.2 MRAP TNFRSF1B
21 anterior scleritis 10.2 MRAP TNFRSF1B
22 arthritis 10.1
23 palindromic rheumatism 10.1 MRAP TNFRSF1B
24 herpes simplex 10.0
25 optic papillitis 10.0 CD40LG MRAP
26 splenic disease 10.0 CD40LG EPO
27 acute retinal necrosis syndrome 10.0 CD40LG MRAP
28 aplastic anemia 10.0 EPO HLA-B SRP72
29 chorioretinitis 10.0 CD40LG MRAP
30 indeterminate leprosy 10.0 CD40LG HLA-B
31 cataract 10.0
32 hypopyon 10.0
33 cervix disease 10.0 CD40LG MRAP
34 vulvitis 9.9 CD40LG MRAP
35 coccidiosis 9.9 CD40LG MRAP
36 intestinal disease 9.9 MRAP TNFRSF1B
37 uveitis 9.9
38 syphilis 9.9
39 byssinosis 9.9 CD40LG MRAP
40 echinococcosis 9.9 CD40LG HLA-B
41 conjunctival disease 9.9 CD40LG MRAP
42 rubella 9.9 CD40LG HLA-B
43 sclerosing cholangitis 9.9 CD40LG HLA-B
44 rheumatoid arthritis 9.9
45 colitis 9.9
46 diabetic autonomic neuropathy 9.9
47 autonomic neuropathy 9.9
48 retinitis 9.9
49 conjunctivitis 9.9
50 juvenile rheumatoid arthritis 9.9

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis
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Symptoms & Phenotypes for Iritis

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GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CNOT1 EPO HLA-B
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Drugs & Therapeutics for Iritis

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Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2
Acyclovir Approved Phase 4 59277-89-3 2022
3 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Not Applicable
5 Dermatologic Agents Phase 4
6 Anti-Infective Agents Phase 4,Phase 2
7 Antiviral Agents Phase 4,Phase 2
8 valacyclovir Phase 4
9
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
11
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
12
Difluprednate Approved Phase 3,Phase 2 23674-86-4 443936
13
Fluprednisolone Approved Phase 3,Phase 2 53-34-9
14
Azathioprine Approved Phase 3 446-86-6 2265
15
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
16 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Not Applicable
17 Antiemetics Phase 3,Phase 2,Not Applicable
18 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
19 Autonomic Agents Phase 3,Phase 2,Not Applicable
20 glucocorticoids Phase 3,Phase 2,Not Applicable
21 Hormone Antagonists Phase 3,Phase 2,Not Applicable
22 Hormones Phase 3,Phase 2,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
24 Methylprednisolone acetate Phase 3,Phase 2
25 Methylprednisolone Hemisuccinate Phase 3,Phase 2
26 Neuroprotective Agents Phase 3,Phase 2
27 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
28 Prednisolone acetate Phase 3,Phase 2
29 Prednisolone hemisuccinate Phase 3,Phase 2
30 Prednisolone phosphate Phase 3,Phase 2
31 Protective Agents Phase 3,Phase 2
32 Antimetabolites Phase 3,Phase 2
33 Antimetabolites, Antineoplastic Phase 3,Phase 2
34 Immunosuppressive Agents Phase 3,Phase 2
35 Liver Extracts Phase 3
36 N-Methylaspartate Phase 3
37 alanine Nutraceutical Phase 3
38 Aspartic Acid Nutraceutical Phase 3
39
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
40
Ranibizumab Approved Phase 2 347396-82-1 459903
41
Gemcitabine Approved Phase 2 95058-81-4 60750
42
Pembrolizumab Approved Phase 2 1374853-91-4
43
Bromfenac Approved July 1997 Phase 2 91714-94-2 60726
44 Antibodies Phase 2,Phase 1
45 Immunoglobulin G Phase 2
46 Immunoglobulins Phase 2,Phase 1
47 triamcinolone acetonide Phase 2
48 Triamcinolone diacetate Phase 2
49 Triamcinolone hexacetonide Phase 2
50 Analgesics Phase 2,Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
3 Zoster Eye Disease Study Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
4 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
5 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
6 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
7 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2 Euphrasia;Prednisolone acetate
8 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
9 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
10 Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration Completed NCT00805233 Phase 2 combination ranibizumab + bromfenac;ranibizumab injection alone
11 Trial to Evaluate Efficacy and Safety of Pembrolizumab and Gemcitabine in HER2-negative ABC Recruiting NCT03025880 Phase 2 Pembrolizumab;Gemcitabine
12 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
13 Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease Terminated NCT00584740 Phase 2 AIN457;Placebo
14 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1 Chicken type II collagen
15 Safety Study of Latanoprost Slow Release Insert Terminated NCT01180062 Phase 1 Latanoprost;Arm 2;Latanoprost SR insert
16 Safety and Surgical Performance Study of Aurosleek Surgical Blades Unknown status NCT01763593
17 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010 Not Applicable
18 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
19 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593 Not Applicable Diclofenac;Dexamethasone
20 Screening for NEI Clinical Studies Completed NCT00001734
21 Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases Completed NCT03206983 Not Applicable
22 To Evaluate Eye Installation-Tear Free Completed NCT02802917 Not Applicable SPF 50 Y49 091 (BAY 987516);SPF 50 X15 158 (BAY 987516);SPF 50 X15 160 (BAY 987516);SPF 50 X57 162 (BAY 987516)

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: iritis

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Genetic Tests for Iritis

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Anatomical Context for Iritis

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MalaCards organs/tissues related to Iritis:

41
Eye, Retina, Liver, Testes, Endothelial, Skin
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Publications for Iritis

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Articles related to Iritis:

(show top 50) (show all 231)
# Title Authors Year
1
Iritis ( 28613659 )
2017
2
Bilateral Iritis after Vaccine for Bladder Cancer. ( 26258277 )
2015
3
Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant. ( 26719491 )
2015
4
Intravitreal aflibercept after bilateral bevacizumab-induced iritis. ( 25871873 )
2015
5
Chronic iritis associated with cutaneous leukocytoclastic vasculitis. ( 25939124 )
2015
6
Corneal Endothelial Cell Loss and Iritis Associated With a New Cosmetic Iris Implant. ( 25811391 )
2015
7
Free-Floating Iris Cyst in a Patient with Recurrent Iritis. ( 26120316 )
2015
8
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. ( 24417640 )
2014
9
Visante OCT in the diagnosis of caterpillar-induced iritis. ( 23931492 )
2013
10
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. ( 24135297 )
2013
11
Restrictive (Mechanical) Strabismus: An Epidemic? DNA or Not, Twins Faces, Texas, DRS, Iritis Monitoring. ( 22747761 )
2012
12
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. ( 23089088 )
2012
13
Lay Person Slit Lamp Detection of Iritis in Absence of an Eye MD: Test of a Portable Model of Cells and Flare. ( 22747766 )
2012
14
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. ( 22205833 )
2011
15
Iritis and pupillary distortion after periorbital cosmetic alexandrite laser. ( 21057804 )
2011
16
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. ( 21573094 )
2011
17
Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success. ( 20581051 )
2010
18
Iritis, ptosis, and sequential severe loss of vision in a patient with essential thrombocytosis. ( 19696799 )
2010
19
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. ( 19606176 )
2009
20
Severe iritis and choroidal effusion following selective laser trabeculoplasty. ( 18831426 )
2008
21
Hypopyon iritis after primary fresh amniotic membrane transplantation. ( 18043192 )
2007
22
Latanoprost induced iritis after vitrectomy surgery. ( 25390234 )
2007
23
Bilateral ankle edema with bilateral iritis. ( 16633708 )
2007
24
Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. ( 17964410 )
2007
25
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. ( 16751847 )
2006
26
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. Does a normal-shaped pupil exclude the diagnosis of iritis. ( 17057143 )
2006
27
Intravitreal ganciclovir injections in aqueous cytomegalovirus DNA positive hypertensive iritis. ( 16200055 )
2006
28
Recurrent iritis after implantation of an iris-fixated phakic intraocular lens for the correction of myopia Case report and clinicopathologic correlation. ( 16863980 )
2006
29
Iritis presumed as secondary to disseminated coccidioidomycosis. ( 17145566 )
2006
30
Effect of etanercept on iritis in patients with ankylosing spondylitis. ( 15529379 )
2004
31
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. ( 15327114 )
2004
32
The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis. ( 12966615 )
2003
33
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. ( 12027105 )
2002
34
Diffuse lamellar keratitis associated with iritis 10 months after laser in situ keratomileusis. ( 11489588 )
2001
35
Pouchitis-associated iritis (uveitis) following total proctocolectomy and ileal pouch-to-anal anastomosis in ulcerative colitis. ( 11240384 )
2001
36
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. ( 11899428 )
2001
37
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. ( 19078446 )
2000
38
Iritis associated with Sweet's syndrome. ( 10971503 )
2000
39
Low-dose methotrexate in the treatment of severe juvenile rheumatoid arthritis and sarcoid iritis. ( 10358815 )
1999
40
Expression of stress-response protein 60 in iritis associated with experimental autoimmune encephalomyelitis. ( 10672873 )
1999
41
Intravenous cidofovir-induced iritis. ( 10028099 )
1999
42
Iritis associated with intravenous cidofovir. ( 10084411 )
1999
43
Cytomegalovirus iritis. ( 9824866 )
1998
44
Prevention of herpes simplex keratitis and iritis. ( 9488290 )
1998
45
Cataract surgery in a patient with severe chronic iritis and corneal endothelial damage. ( 9682104 )
1998
46
Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. ( 9508240 )
1998
47
Sensorineural hearing loss, iritis and ankylosing spondylitis. ( 9973173 )
1998
48
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. ( 9194719 )
1997
49
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. ( 9194724 )
1997
50
Recurrent iritis after intravenous administration of cidofovir. ( 9332544 )
1997
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Variations for Iritis

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Expression for Iritis

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Search GEO for disease gene expression data for Iritis.
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Pathways for Iritis

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Pathways related to Iritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 10.82 CD40LG TNFRSF1B
2
Inflammatory Response Pathway 1
10.14 CD40LG TNFRSF1B
Sources

GO Terms for Iritis

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Cellular components related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD40LG EPO HLA-B PHB2

Biological processes related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 8.62 CNOT1 PHB2

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 estrogen receptor binding GO:0030331 8.62 CNOT1 PHB2
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Sources for Iritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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