MCID: IRT001
MIFTS: 45

Iritis

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Iritis

MalaCards integrated aliases for Iritis:

Name: Iritis 12 74 44 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1406
MeSH 44 D007500
NCIt 50 C50621
SNOMED-CT 67 65074000
UMLS 71 C0022081

Summaries for Iritis

MalaCards based summary : Iritis is related to severe cutaneous adverse reaction and spondyloarthropathy 1. An important gene associated with Iritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Difluprednate and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Wikipedia : 74 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Iritis

Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 865)
# Related Disease Score Top Affiliating Genes
1 severe cutaneous adverse reaction 31.2 TNF HLA-B CRP CD8A CD4
2 spondyloarthropathy 1 30.5 TNF NOD2 MRAP IL6 IL17A HLA-B
3 neuroretinitis 30.4 CRP CD4 ACE
4 enthesopathy 30.2 TNF ERAP1 CRP CCR6
5 spondylarthropathy 30.2 TNF HLA-B
6 typhoid fever 30.1 TNF IL6 CRP CCR6
7 scleritis 30.1 TNF CRP CCR6
8 pouchitis 30.1 TNF NOD2
9 arthropathy 30.0 TNF IL6 HLA-B CRP
10 endophthalmitis 30.0 VEGFA TNF IL6 CRP
11 conjunctivitis 30.0 TNF IL6 IL10
12 latent syphilis 29.9 CD8A CD4
13 macular retinal edema 29.9 VEGFA TNF IL6 ACE
14 thrombocytosis 29.8 IL6 EPO CRP
15 secondary syphilis 29.8 CRP CD8A CD4
16 open-angle glaucoma 29.8 VEGFA TNF IL6 ACE
17 lipid storage disease 29.7 TNF IL6 CRP CCR6
18 pericarditis 29.7 TNF IL6 CRP ACE
19 juvenile rheumatoid arthritis 29.7 TNF IL6 IL10 CRP
20 coccidioidomycosis 29.7 IL17A CD4 CCR6
21 mumps 29.6 TNF IL6 IL10
22 optic papillitis 29.6 RBP3 MRAP CRP CD4 ACE
23 sarcoidosis 1 29.6 TNF NOD2 CRP CD8A CD4 CCR6
24 pustulosis of palm and sole 29.6 TNF IL17A CRP CCR6
25 syphilis 29.5 IL17A CRP CD8A CD4 CCR6 ACE
26 blau syndrome 29.4 VEGFA TNF NOD2 IL10
27 lyme disease 29.4 TNF IL6 IL17A CRP
28 cysticercosis 29.4 IL6 IL10 CD4
29 erythema nodosum 29.4 TNF NOD2 IL6 IL10 CRP
30 poliomyelitis 29.4 TNF IL10 CD8A CD4
31 essential thrombocythemia 29.3 VEGFA TNF IL6 EPO CRP
32 vasculitis 29.3 TNF IL6 IL17A HLA-B CRP
33 bacterial conjunctivitis 29.3 TNF IL6 IL10 CRP
34 rheumatic fever 29.3 TNF IL6 IL10 ACE
35 uveitis 29.3 TNF RBP3 NOD2 IL6 IL17A IL10
36 dermatitis herpetiformis 29.2 TNF IL17A IL10
37 cytomegalovirus retinitis 29.2 TNF IL10 HLA-B CD8A CD4
38 herpes zoster 29.2 TNF IL10 HLA-B CD8A CD4 CCR6
39 vitiligo-associated multiple autoimmune disease susceptibility 1 29.1 IL17A HLA-B CD8A CD4 CCR6
40 chlamydia 29.0 TNF IL6 IL17A IL10 CRP
41 intestinal perforation 29.0 VEGFA TNF NOD2 IL6 CRP CD4
42 brucellosis 29.0 TNF IL6 IL17A IL10 CRP
43 chlamydia pneumonia 28.9 TNF IL6 IL10 CRP CD8A CD4
44 spondyloarthropathy 28.8 TNF IL6 IL17A IL10 HLA-B
45 chickenpox 28.8 TNF IL6 IL10 CRP CD8A CD4
46 spondylitis 28.8 TNF NOD2 IL6 IL17A IL10 HLA-B
47 endocarditis 28.8 TNF IL6 IL17A IL10 CRP
48 reactive arthritis 28.7 TNF IL6 IL17A IL10 HLA-B CRP
49 colitis 28.7 TNF NOD2 IL6 IL17A IL10 CD4
50 meningitis 28.6 VEGFA TNF IL6 IL17A IL10 HLA-B

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis

Symptoms & Phenotypes for Iritis

MGI Mouse Phenotypes related to Iritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 ACE CCR6 CD4 CD8A EPO ERAP1
2 endocrine/exocrine gland MP:0005379 10.02 ACE CD4 CD8A ERAP1 IL10 IL17A
3 immune system MP:0005387 9.97 ACE CCR6 CD4 CD8A CRP EPO
4 digestive/alimentary MP:0005381 9.91 CD4 IL10 IL17A IL6 NOD2 TNF
5 liver/biliary system MP:0005370 9.5 ACE EPO IL10 IL6 MRAP TNF
6 respiratory system MP:0005388 9.17 EPO IL10 IL17A IL6 MRAP TNF

Drugs & Therapeutics for Iritis

Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Difluprednate Approved Phase 2 23674-86-4 443936
2
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
3 Immunologic Factors Phase 2
4 Triamcinolone hexacetonide Phase 2
5 triamcinolone acetonide Phase 2
6 Triamcinolone diacetate Phase 2
7 Immunosuppressive Agents Phase 2
8
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
9
Lactitol Approved, Investigational 585-86-4 157355
10
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
11
Diclofenac Approved, Vet_approved 15307-86-5 3033
12 Cathartics
13 Pharmaceutical Solutions
14 Cyclooxygenase Inhibitors
15 Anti-Inflammatory Agents, Non-Steroidal
16 Ophthalmic Solutions
17 BB 1101
18 Antirheumatic Agents
19 Analgesics, Non-Narcotic
20 Analgesics
21 Laxatives

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Inluding Iritis, Cyclitis, Iridocyclitis, and Panuveitis). Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
2 Treatment of Active Anterior Uveitis Associated With JIA, Using Humanized Anti-Tac (HAT, Daclizumab) Completed NCT00130637 Phase 2 Daclizumab
3 PEMF an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
4 Evaluation and Treatment Protocol for Patients With Intraocular Inflammatory Disease (Uveitis) Completed NCT00006188
5 Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Ocular Inflammatory or Immunologic Diseases Completed NCT00001734
6 Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function. Completed NCT00476593 Diclofenac;Dexamethasone
7 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Withdrawn NCT02416128 Euphrasia;Prednisolone acetate

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Loteprednol
loteprednol etabonate
Tropicamide

Cochrane evidence based reviews: iritis

Genetic Tests for Iritis

Anatomical Context for Iritis

MalaCards organs/tissues related to Iritis:

40
Eye, Retina, Endothelial, Skin, Brain, Lymph Node, Thyroid

Publications for Iritis

Articles related to Iritis:

(show top 50) (show all 1291)
# Title Authors PMID Year
1
Prevalence of autoimmune disorders among bladder pain syndrome patients' relatives. 61
32964777 2021
2
Clinical features of uveitis in elderly patients in central Tokyo (2013-2018). 61
33544350 2021
3
Liposomal drug delivery system for anti-inflammatory treatment after cataract surgery: a phase I/II clinical trial. 61
33569720 2021
4
Photoablative cosmetic iridoplasty: effective, safe, and predictable-eye color change in 1176 eyes. 61
33484383 2021
5
Comparison of the effect of teicoplanin and vancomycin on experimental methicillin-resistant staphylococcus aureus keratitis. 61
33506369 2021
6
Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1). 61
32544560 2020
7
Anti-interleukin-6 receptor therapy with tocilizumab for refractory pseudophakic cystoid macular edema. 61
32875161 2020
8
Ocular trauma secondary to exercise resistance bands during the COVID-19 pandemic. 61
33317864 2020
9
Ocular Injuries Associated with Elastic Exercise Bands. 61
33165305 2020
10
Retrospective analysis of visual outcomes in retropupillary iris-suture-fixated rigid intraocular lens in a tertiary eye center in southern India. 61
33179206 2020
11
[Intraocular lens explantation and retroiridal iris claw lens implantation via the pars plana : Video article]. 61
33034738 2020
12
Multiple evanescent white dot syndrome and panuveitis: a case report. 61
33123841 2020
13
[Unusual iritis-A case report of endophthalmitis caused by Listeria monocytogenes]. 61
33103228 2020
14
Patient-Reported Complications after Intravitreal Injection and Their Predictive Factors. 61
33059077 2020
15
Sutured Custom Foldable Silicone Artificial Iris Implantation Combined With Intraocular Lens Implantation and Penetrating Keratoplasty: Safety and Efficacy Outcomes. 61
33086281 2020
16
[Ocular ischemic syndrome : An important differential diagnosis]. 61
32975660 2020
17
Niosomes: Do They Increase the Potency of Topical Natamycin Ketorolac Formula in Treating Aspergillus Keratitis? An Experimental Study. 61
32357092 2020
18
Functional outcomes after combined iris and intraocular lens implantation in various iris and lens defects. 61
32933506 2020
19
The frequency of uveitis in patients with adult versus childhood spondyloarthritis. 61
32868451 2020
20
Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery. 61
32541407 2020
21
Safety and Efficacy of 0.1% Nepafenac versus 1% Prednisolone Acetate Eye Drops after Laser Peripheral Iridotomy: A Prospective, Randomized Trial. 61
32672612 2020
22
Reoperations for Complications Within 90 Days After Glaucoma Surgery. 61
32134830 2020
23
Effect of intracameral phenylephrine/ketorolac 1.0%/0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia following cataract surgery. 61
32221152 2020
24
Selective laser trabeculoplasty in exfoliative glaucoma eyes with prior argon laser trabeculoplasty. 61
31091010 2020
25
Anti-Neutrophil Cytoplasmic Antibody-Associated Ocular Manifestations in Japan: A Review of 18 Patients. 61
32078414 2020
26
Clinical Features of Japanese Patients with Ocular Inflammation and Their Surgical Procedures Over the Course of 20 Years. 61
33061264 2020
27
Clinical features of anterior uveitis caused by three different herpes viruses. 61
31134426 2019
28
The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: a review of the literature. 61
31485882 2019
29
Epidemiology of Adult Uveitis in a Northern Ireland Tertiary Referral Centre. 61
31619852 2019
30
Known and novel ocular toxicities of biologics, targeted agents, and traditional chemotherapeutics. 61
31098752 2019
31
West Indies Glaucoma Laser Study (WIGLS) 3. Anterior Chamber Inflammation Following Selective Laser Trabeculoplasty in Afro-Caribbeans with Open-angle Glaucoma. 61
30921277 2019
32
Cost and Visit Duration of Same-Day Access at an Academic Ophthalmology Department vs Emergency Department. 61
31021382 2019
33
Calcified mucinous adenocarcinoma of the stomach metastatic to the iris: a case report. 61
30841908 2019
34
Frontal fibrosing alopecia demographics: a survey of 29 patients. 61
30893399 2019
35
The Impact of Inflammatory Bowel Disease in Canada 2018: Extra-intestinal Diseases in IBD. 61
31294387 2019
36
Evaluation of the etiology of persistent iritis after cataract surgery. 61
30778743 2019
37
Comparative analysis of retropupillary iris claw versus scleral-fixated intraocular lens in the management of post-cataract aphakia. 61
30574894 2019
38
A Case of Unilateral Coccidioidal Chorioretinitis in a Patient with HIV-Associated Meningoencephalitis. 61
31687242 2019
39
Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients. 61
30403300 2018
40
Safety of IBI-10090 for inflammation associated with cataract surgery: Phase 3 multicenter study. 61
30139638 2018
41
Extraintestinal Manifestations in Vedolizumab and Anti-TNF-Treated Patients With Inflammatory Bowel Disease. 61
29668916 2018
42
Effectiveness of real-time PCR for diagnosis and prognosis of varicella-zoster virus keratitis. 61
29948430 2018
43
Herpes Zoster Optic Neuropathy. 61
29266031 2018
44
Iris metastasis preceding diagnosis of gastric signet ring cell adenocarcinoma: a case report. 61
29801472 2018
45
Cyclodestructive procedures for non-refractory glaucoma. 61
29694684 2018
46
Visually Significant Cystoid Macula Edema After Glaucoma Drainage Implant Surgery. 61
29271812 2018
47
[Candida infiltrations in the iris and lens during iritis and situation after sepsis]. 61
28144736 2018
48
Medical Malpractice in Uveitis: A Review of Clinical Entities and Outcomes. 61
27715388 2018
49
Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. 61
29670780 2018
50
The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science. 61
30505307 2018

Variations for Iritis

Expression for Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for Iritis

Pathways related to Iritis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 VEGFA TNF NOD2 IL6 IL17A IL10
2
Show member pathways
13.27 VEGFA TNF NOD2 IL6 IL17A IL10
3
Show member pathways
12.52 TNF IL6 IL17A IL10 CD4
4
Show member pathways
12.51 TNF IL6 IL17A IL10 CD8A CD4
5
Show member pathways
12.5 VEGFA TNF IL6 IL17A IL10 HLA-B
6
Show member pathways
12.49 TNF NOD2 IL6 IL17A IL10 CD4
7 12.28 TNF IL6 HLA-B CD4
8
Show member pathways
12.27 TNF IL6 IL10 CCR6
9
Show member pathways
12.21 TNF IL6 IL17A IL10 HLA-B
10 12.18 TNF NOD2 IL6 IL10
11 12.12 VEGFA TNF IL6 IL10
12 11.99 TNF IL6 IL10 CD8A CD4
13 11.89 VEGFA TNF IL6 IL17A IL10
14 11.82 VEGFA TNF IL6 IL17A
15 11.8 TNF IL6 EPO CD8A CD4
16
Show member pathways
11.79 IL6 IL17A CD4
17 11.7 TNF IL6 IL10
18 11.63 TNF IL6 IL10 CCR6
19
Show member pathways
11.61 VEGFA TNF IL6
20
Show member pathways
11.6 TNF IL6 IL17A IL10 CD4
21 11.52 TNF IL6 IL10 CD8A CD4
22 11.5 TNF IL6 IL10
23 11.5 TNF IL6 IL10 EPO CD8A CD4
24 11.48 TNF IL6 IL10
25 11.47 VEGFA IL6 EPO
26 11.33 TNF IL6 IL10
27 11.3 TNF IL6 IL10
28 11.25 TNF IL6 IL17A
29 11.13 TNF IL6 IL10 CD4
30 11 TNF IL17A IL10 CD8A CD4 CCR6
31 10.98 TNF IL6 CRP

GO Terms for Iritis

Cellular components related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.73 TNF IL17A CD8A CD4 CCR6 ACE
2 cell surface GO:0009986 9.7 VEGFA TNF NOD2 HLA-B EPO CD4
3 extracellular space GO:0005615 9.65 VEGFA TNF RBP3 IL6 IL17A IL10
4 extracellular region GO:0005576 9.36 VEGFA TNF RBP3 IL6 IL17A IL10

Biological processes related to Iritis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.09 NOD2 IL17A HLA-B ERAP1 CD8A CD4
2 adaptive immune response GO:0002250 10.03 IL17A HLA-B ERAP1 CD8A CD4
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 VEGFA TNF EPO
4 cellular response to lipopolysaccharide GO:0071222 9.85 TNF NOD2 IL6 IL10
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 VEGFA TNF IL6
6 positive regulation of tumor necrosis factor production GO:0032760 9.83 NOD2 IL6 IL17A
7 defense response to Gram-negative bacterium GO:0050829 9.83 IL6 IL17A CD4
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 VEGFA TNF NOD2 EPO CD4
9 response to glucocorticoid GO:0051384 9.81 TNF IL6 IL10
10 positive regulation of MAPK cascade GO:0043410 9.81 VEGFA NOD2 IL6 CD4
11 positive regulation of protein kinase activity GO:0045860 9.79 TNF EPO CD4
12 positive regulation of MAP kinase activity GO:0043406 9.78 VEGFA TNF NOD2
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 VEGFA NOD2 IL6 CD4
14 positive regulation of interleukin-8 production GO:0032757 9.76 TNF NOD2 IL6
15 positive regulation of interleukin-6 production GO:0032755 9.76 TNF NOD2 IL6 IL17A
16 humoral immune response GO:0006959 9.75 TNF IL6 CCR6
17 cytokine-mediated signaling pathway GO:0019221 9.73 VEGFA TNF IL6 IL17A IL10 CD4
18 acute-phase response GO:0006953 9.71 IL6 EPO CRP
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 VEGFA TNF IL6 EPO
20 positive regulation of JAK-STAT cascade GO:0046427 9.7 TNF IL6 IL10
21 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL6
22 detection of bacterium GO:0016045 9.67 NOD2 HLA-B
23 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.67 HLA-B ERAP1 ACE
24 positive regulation of interleukin-1 beta production GO:0032731 9.67 TNF NOD2 IL6 IL17A
25 response to salt stress GO:0009651 9.65 TNF EPO
26 neutrophil mediated immunity GO:0002446 9.65 IL6 ACE
27 endothelial cell apoptotic process GO:0072577 9.64 TNF IL10
28 response to peptidoglycan GO:0032494 9.64 NOD2 IL6
29 vascular endothelial growth factor production GO:0010573 9.62 TNF IL6
30 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.6 TNF NOD2
31 negative regulation of cytokine production involved in immune response GO:0002719 9.59 TNF IL10
32 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.57 VEGFA ACE
33 negative regulation of interleukin-18 production GO:0032701 9.56 NOD2 IL10
34 defense response to Gram-positive bacterium GO:0050830 9.55 TNF NOD2 IL6 IL17A CRP
35 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
36 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.26 TNF NOD2 IL6 IL17A
37 immune response GO:0006955 9.23 TNF IL6 IL17A IL10 HLA-B CD8A

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.09 VEGFA TNF SRP72 RBP3 NOD2 MRAP
2 cytokine activity GO:0005125 9.1 VEGFA TNF IL6 IL17A IL10 EPO
3 interleukin-6 receptor binding GO:0005138 8.96 IL6 ERAP1

Sources for Iritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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