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MCID: IRN001
MIFTS: 55

Iron Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Iron Deficiency Anemia

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MalaCards integrated aliases for Iron Deficiency Anemia:

Name: Iron Deficiency Anemia 12 29 55 6 15 73
Iron-Deficiency Anemia 63

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11758
ICD9CM 35 280.8
ICD10 33 D50
Sources

Summaries for Iron Deficiency Anemia

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PubMed Health : 63 About iron-deficiency anemia: Iron-deficiency anemia is a common, easily treated condition that occurs if you don't have enough iron in your body. Low iron levels usually are due to blood loss, poor diet, or an inability to absorb enough iron from food.

MalaCards based summary : Iron Deficiency Anemia, also known as iron-deficiency anemia, is related to iron-refractory iron deficiency anemia and hyperferritinemia with or without cataract. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways are Insulin receptor recycling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Iron and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A nutritional deficiency disease that is characterized by pallor, fatigue, lightheadedness, and weakness and has material basis in low total body iron causing impaired synthesis of red blood cells.

Wikipedia : 76 Iron-deficiency anemia is anemia caused by a lack of iron. Anemia is defined as a decrease in the number... more...

Sources

Related Diseases for Iron Deficiency Anemia

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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.4 EPO HJV TMPRSS6
2 hyperferritinemia with or without cataract 32.5 HFE TF
3 microcytic anemia 32.4 EPO SLC11A2 TF TFRC TMPRSS6
4 iron metabolism disease 31.8 EPO HFE HJV SLC11A2 SLC40A1 TF
5 thalassemia 31.0 EPO HFE TF TFRC
6 thrombocytosis 30.4 CRP EPO IL6 THPO
7 beta-thalassemia 30.4 EPO HFE TF TFR2 TFRC
8 restless legs syndrome 30.3 EPO SLC11A2 TFRC
9 hemoglobinopathy 30.2 EPO HAMP HFE TF
10 polycythemia 30.1 EPO TFRC THPO
11 acquired polycythemia 30.1 EPO TF
12 deficiency anemia 30.0 CRP EPO HAMP HFE HJV IL6
13 kidney disease 30.0 CRP EPO FGF23 IL6 TF
14 chronic kidney failure 29.9 CRP EPO FGF23 IL6 TF
15 hemosiderosis 29.9 EPO HAMP HFE SLC11A2 SLC40A1 TF
16 purpura 29.8 CRP IL6 THPO
17 intussusception 29.7 CRP IL6
18 malaria 29.6 CRP EPO HAMP IL6 TF TFRC
19 nutritional deficiency disease 29.2 CRP EPO HAMP IL6 TF TMPRSS6
20 hemochromatosis, type 1 28.8 HAMP HFE HJV SLC11A2 SLC40A1 TF
21 gastric antral vascular ectasia 11.5
22 plummer vinson syndrome 11.5
23 autoimmune atrophic gastritis 11.5
24 anemia, congenital dyserythropoietic, type iii 11.1
25 ancylostomiasis 11.1
26 celiac disease 1 10.6
27 inflammatory bowel disease 10.6
28 pica disease 10.4
29 helicobacter pylori infection 10.4
30 thrombosis 10.4
31 gastritis 10.4
32 pulmonary hemosiderosis 10.3
33 thrombocytopenia 10.3
34 hemochromatosis, type 2a 10.2 HAMP HJV
35 plethora of newborn 10.2 EPO TF
36 hemangioma 10.2
37 splenic disease 10.2 EPO THPO
38 melancholia 10.2 CRP TF
39 fetal erythroblastosis 10.2 EPO TFRC
40 angiomatous meningioma 10.2 TF TFRC
41 autoimmune gastritis 10.2
42 pure red-cell aplasia 10.2 EPO TF
43 hemoglobin h disease 10.2 EPO TF TFRC
44 hypochromic microcytic anemia 10.1 SLC11A2 TF TMPRSS6
45 vibrio vulnificus infection 10.1 EPO IL6
46 blue rubber bleb nevus 10.1
47 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
48 crohn's disease 10.1
49 diabetes mellitus 10.1
50 lymphoma 10.1

Comorbidity relations with Iron Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 99)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Alcoholic Liver Cirrhosis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Ascending Colon Cancer Atrophic Gastritis
Benign Essential Hypertension Bronchitis
Bronchopneumonia Cecal Benign Neoplasm
Celiac Disease 1 Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chronic Kidney Failure
Chronic Myocardial Ischemia Chylomicron Retention Disease
Colorectal Cancer Conjunctivitis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Duodenitis Dysthymic Disorder
Encephalopathy Esophageal Candidiasis
Esophageal Disease Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Folic Acid Deficiency Anemia Gastric Cancer
Gastrointestinal System Cancer Generalized Atherosclerosis
Gout Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypersplenism Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypoglycemic Coma Hypothyroidism

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to Iron Deficiency Anemia
Sources

Symptoms & Phenotypes for Iron Deficiency Anemia

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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 EPO FGF23 HFE HJV IL6 SLC11A2
2 homeostasis/metabolism MP:0005376 10.13 CRP EPO FGF23 HFE HJV IL6
3 cardiovascular system MP:0005385 10.11 CRP EPO FGF23 HJV IL6 SLC11A2
4 growth/size/body region MP:0005378 10.06 FGF23 HFE IL6 SLC11A2 SLC40A1 TF
5 immune system MP:0005387 10.03 CRP EPO FGF23 HFE HJV IL6
6 digestive/alimentary MP:0005381 9.91 FGF23 HFE IL6 SLC40A1 TFRC TMPRSS6
7 integument MP:0010771 9.76 EPO FGF23 HJV IL6 SLC11A2 SLC40A1
8 liver/biliary system MP:0005370 9.61 EPO HFE HJV IL6 SLC11A2 SLC40A1
9 mortality/aging MP:0010768 9.32 EPO FGF23 HFE HJV IL6 SLC11A2
Sources

Drugs & Therapeutics for Iron Deficiency Anemia

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PubMedHealth treatment related to Iron Deficiency Anemia: 63

Treatment for iron-deficiency anemia will depend on its cause and severity. Treatments may include dietary changes and supplements, medicines, and surgery.Severe iron-deficiency anemia may require a blood transfusion, iron injections, or intravenous (IV) iron therapy. Treatment may need to be done in a hospital.The goals of treating iron-deficiency anemia are to treat its underlying cause and restore normal levels of red blood cells, hemoglobin, and iron.

Drugs for Iron Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 283)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6 23925
2
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 1406-66-2 14986
3
Copper Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-50-8 27099
4
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 7440-66-6
5
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 6006 143
6
Ferrous gluconate Approved Phase 4,Phase 1,Not Applicable 299-29-6
7
Ferrous fumarate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 141-01-5
8
Halofantrine Approved Phase 4 69756-53-2 37393
9
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 44475014
10
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 13422-55-4
11
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
12
Nicotinamide Approved, Investigational Phase 4,Phase 3,Not Applicable 98-92-0 936
13
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7782-49-2
14
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
15
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
16
Clarithromycin Approved Phase 4 81103-11-9 84029
17 Iron protein succinylate Approved, Investigational Phase 4,Not Applicable 250705-13-6
18
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
19
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 59-02-9 14985
20
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 5785 54670067
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
22
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 11103-57-4, 68-26-8 445354
23
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
24
Vitamin D3 Approved, Nutraceutical Phase 4,Not Applicable 67-97-0 5280795 6221
25
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
26
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
27
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 68-19-9 44176380
28
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 59-67-6 938
29
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 65-23-6 1054
30
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
31
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 83-88-5 493570
32
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
33 Tocotrienol Investigational Phase 4,Phase 3,Phase 1,Not Applicable 6829-55-6
34
Cobalamin Experimental Phase 4,Phase 2,Phase 3,Not Applicable 13408-78-1 6438156
35 Antioxidants Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
36 Vitamin B9 Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Iron Supplement Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
38 Tocotrienols Phase 4,Phase 3,Phase 1,Not Applicable
39 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Folate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Tocopherols Phase 4,Phase 3,Phase 1,Not Applicable
45 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Hematinics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47 Ferric oxide, saccharated Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Teferrol Phase 4,Phase 3,Not Applicable
49 retinol Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
50 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 611)
# Name Status NCT ID Phase Drugs
1 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
2 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
3 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
4 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
5 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
6 Iron Deficiency In Pulmonary Hypertension Unknown status NCT01288651 Phase 4 Ferricarboxymaltose
7 Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance In Non Anemic Premenopausal Women With Low Ferritin Levels Unknown status NCT01374776 Phase 4 Double blind, randomized, placebo controlled inter
8 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
9 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
10 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
11 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Unknown status NCT02997046 Phase 4
12 Intravenous Iron for Correction of Anaemia After Colorectal Surgery Unknown status NCT02999217 Phase 4 Iron isomaltoside;Saline
13 Iron Absorption Trial Unknown status NCT02228902 Phase 4 Ferrous fumarate;Ferrous gluconate
14 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
15 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
16 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
17 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
18 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
19 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Completed NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
20 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
21 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
22 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
23 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
24 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
25 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
26 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
27 Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
28 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
29 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
30 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
31 Oral Lactoferrin Versus Iron Supplementation During Pregnancy Completed NCT03542825 Phase 4 Lactoferrin;Iron Supplement;Chelates, Iron
32 Iron Substitution in Blood Donors Completed NCT01519830 Phase 4 Iron carboxymaltose (Ferinject);Placebo
33 Optimizing Iron Suppletion After Roux-en-Y Gastric Bypass Completed NCT02271997 Phase 4 Ferrous fumarate;Ferrous gluconate;Iron(III)carboxymaltose
34 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
35 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
36 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
37 Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age Completed NCT01110356 Phase 4 Ferinject
38 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
39 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
40 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
41 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
42 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
43 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
44 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
45 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
46 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
47 Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study) Completed NCT01609387 Phase 4
48 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
49 Periodic Versus Continuous IV Iron Supplementation in HD Patients Completed NCT02787824 Phase 4 Iron Sucrose Supplement
50 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4

Search NIH Clinical Center for Iron Deficiency Anemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Iron Deficiency Anemia

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Genetic tests related to Iron Deficiency Anemia:

# Genetic test Affiliating Genes
1 Iron Deficiency Anemia 29
Sources

Anatomical Context for Iron Deficiency Anemia

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MalaCards organs/tissues related to Iron Deficiency Anemia:

41
Kidney, Heart, Testes, Liver, Bone, Brain, Thyroid
Sources

Publications for Iron Deficiency Anemia

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Articles related to Iron Deficiency Anemia:

(show top 50) (show all 1257)
# Title Authors Year
1
Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia. ( 29795991 )
2018
2
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
3
Protein-Losing Enteropathy in the Setting of Severe Iron Deficiency Anemia. ( 29511696 )
2018
4
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma. ( 29955854 )
2018
5
Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood are Associated with Behavior Problems in Adolescent Boys: Results from the BogotA! School Children Cohort. ( 29897579 )
2018
6
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis. ( 29499633 )
2018
7
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs. ( 29772815 )
2018
8
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
9
A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review. ( 29851802 )
2018
10
Cooking in Iron Pots for Iron Deficiency Anemia: The Traditional Way Forward? ( 29948738 )
2018
11
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
12
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
13
Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen. ( 29850236 )
2018
14
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
15
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
16
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
17
A comment on the comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia. ( 29981266 )
2018
18
Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia. ( 29868633 )
2018
19
Efficacy of ferrous bis-glycinate versus ferrous glycine sulfate in the treatment of iron deficiency anemia with pregnancy: a randomized double-blind clinical trial. ( 29843553 )
2018
20
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
21
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
22
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
23
The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia. ( 29928945 )
2018
24
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
25
Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis. ( 29767699 )
2018
26
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
27
Iron Deficiency Anemia with Menorrhagia: Ferric Carboxymaltose a Safer Alternative to Blood Transfusion. ( 29962808 )
2018
28
New Onset Iron Deficiency Anemia in Chronic Therapeutic Plasma Exchange Patients. ( 29970428 )
2018
29
Relation between Depressive Disorder and Iron Deficiency Anemia among Adults Reporting to a Secondary Healthcare Facility: A Hospital-Based Case Control Study. ( 29848423 )
2018
30
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial. ( 29917215 )
2018
31
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
32
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
33
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
34
Effects of an enhanced iron dense foods offering in the daily meals served in geriatric institutions on measures of iron deficiency anemia. ( 29801478 )
2018
35
Usefulness of Oral Ferric Citrate in Patients With Iron-Deficiency Anemia and Chronic Kidney Disease With or Without Heart Failure. ( 29961562 )
2018
36
A Toddler With Treatment-Resistant Iron Deficiency Anemia. ( 29950397 )
2018
37
Angular cheilitis induced by iron deficiency anemia. ( 30102595 )
2018
38
Intestinal DMT1 Is Essential for Optimal Assimilation of Dietary Copper in Male and Female Mice with Iron-Deficiency Anemia. ( 30137476 )
2018
39
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease. ( 30150549 )
2018
40
Unexplained iron deficiency anemia: does Helicobacter pylori have a role to play? ( 30151206 )
2018
41
Efficacy and safety of ferric carboxymaltose versus ferrous sulfate for iron deficiency anemia during pregnancy: subgroup analysis of Korean women. ( 30153811 )
2018
42
Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma. ( 30155291 )
2018
43
Koilonychia in Iron-Deficiency Anemia. ( 30157401 )
2018
44
Iron deficiency anemia in gastric cancer: a Canadian retrospective review. ( 30179903 )
2018
45
Ferumoxytol for the treatment of iron deficiency anemia. ( 30188740 )
2018
46
Safety and efficacy of intravenous ferric carboxymaltose in Japanese patients with iron-deficiency anemia caused by digestive diseases: an open-label, single-arm study. ( 30194568 )
2018
47
Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia. ( 30197123 )
2018
48
Severe iron deficiency anemia: red blood cell transfusion or intravenous iron? ( 30198610 )
2018
49
Earlier use of capsule endoscopy in inpatients with melena or severe iron deficiency anemia reduces need for colonoscopy and shortens hospital stay. ( 30211295 )
2018
50
Health-related quality of life in patients with iron deficiency anemia: impact of treatment with intravenous iron. ( 30214332 )
2018
Sources

Variations for Iron Deficiency Anemia

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ClinVar genetic disease variations for Iron Deficiency Anemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TF NM_001063.3(TF): c.829G> A (p.Gly277Ser) single nucleotide variant Likely benign rs1799899 GRCh37 Chromosome 3, 133475812: 133475812
2 TF NM_001063.3(TF): c.829G> A (p.Gly277Ser) single nucleotide variant Likely benign rs1799899 GRCh38 Chromosome 3, 133756968: 133756968
Sources

Expression for Iron Deficiency Anemia

About this section
Search GEO for disease gene expression data for Iron Deficiency Anemia.
Sources

Pathways for Iron Deficiency Anemia

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Pathways related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Insulin receptor recycling 66
Show member pathways
 12.2 SLC11A2 SLC40A1 TF TFRC
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.72 EPO IL6 THPO
3
HIF-1 signaling pathway 37
11.62 EPO IL6 TF TFRC
4
Hematopoietic cell lineage 37
11.54 EPO IL6 TFRC THPO
5
HIF-1-alpha transcription factor network 1
11.42 EPO TF TFRC
6
Mineral absorption 37
11.29 SLC11A2 SLC40A1 TF
7
Differentiation Pathway 1
11.23 EPO IL6 TF
8
Ferroptosis 37
11.06 SLC11A2 SLC40A1 TF TFRC
9
Overview of nanoparticle effects 1
10.77 CRP IL6
10
Iron metabolism in placenta 1
10.18 HAMP SLC11A2 SLC40A1 TF TFR2 TFRC
11
Hfe effect on hepcidin production 1
10.1 HAMP HFE HJV TMPRSS6
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GO Terms for Iron Deficiency Anemia

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Cellular components related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 CRP EPO FGF23 HAMP IL6 TF
2 cytoplasmic vesicle GO:0031410 9.83 HFE SLC11A2 TF TFR2 TFRC
3 cell surface GO:0009986 9.8 EPO HJV SLC11A2 TF TFRC
4 extracellular space GO:0005615 9.7 CRP EPO FGF23 HAMP HFE HJV
5 early endosome GO:0005769 9.67 HFE SLC11A2 TF TFRC
6 recycling endosome GO:0055037 9.56 HFE SLC11A2 TF TFRC
7 basal part of cell GO:0045178 9.33 HFE SLC11A2 TF
8 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC

Biological processes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.91 EPO FGF23 HAMP IL6 THPO
2 transferrin transport GO:0033572 9.71 HFE TF TFR2 TFRC
3 response to iron ion GO:0010039 9.67 HAMP HFE SLC11A2 TFR2
4 acute-phase response GO:0006953 9.63 CRP EPO HAMP HFE IL6 TFR2
5 iron ion transport GO:0006826 9.62 SLC11A2 SLC40A1 TF TFR2
6 cellular response to iron ion GO:0071281 9.61 HFE TF TFR2
7 cellular iron ion homeostasis GO:0006879 9.61 HAMP HFE HJV SLC11A2 SLC40A1 TF
8 positive regulation of receptor-mediated endocytosis GO:0048260 9.57 HFE TF
9 response to vitamin A GO:0033189 9.56 EPO HAMP
10 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A2 SLC40A1
11 cellular response to interleukin-6 GO:0071354 9.55 FGF23 HAMP
12 negative regulation of lipid storage GO:0010888 9.54 CRP IL6
13 positive regulation of peptide hormone secretion GO:0090277 9.52 HFE TFR2
14 iron ion import GO:0097286 9.49 TFR2 TFRC
15 regulation of iron ion import GO:1900390 9.48 HFE TF
16 response to iron ion starvation GO:1990641 9.46 HAMP HFE
17 iron ion homeostasis GO:0055072 9.17 HFE HJV SLC11A2 SLC40A1 TF TFR2

Molecular functions related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.61 FGF23 IL6 THPO
2 hormone activity GO:0005179 9.58 EPO HAMP THPO
3 co-receptor binding GO:0039706 9.37 HFE TFR2
4 iron ion transmembrane transporter activity GO:0005381 9.32 SLC11A2 SLC40A1
5 ferrous iron transmembrane transporter activity GO:0015093 9.26 SLC11A2 SLC40A1
6 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
7 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
8 transferrin receptor binding GO:1990459 8.8 HFE HJV TF
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Sources for Iron Deficiency Anemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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