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MCID: IRN001
MIFTS: 59

Iron Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Iron Deficiency Anemia

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MalaCards integrated aliases for Iron Deficiency Anemia:

Name: Iron Deficiency Anemia 12 29 54 6 15 71
Iron-Deficiency Anemia 62

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11758
ICD9CM 34 280.8
ICD10 32 D50 D50.9
UMLS 71 C0029810 C0162316
Sources

Summaries for Iron Deficiency Anemia

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PubMed Health : 62 About iron-deficiency anemia: Iron-deficiency anemia is a common, easily treated condition that occurs if you don't have enough iron in your body. Low iron levels usually are due to blood loss, poor diet, or an inability to absorb enough iron from food.

MalaCards based summary : Iron Deficiency Anemia, also known as iron-deficiency anemia, is related to iron-refractory iron deficiency anemia and hyperferritinemia with or without cataract. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways are Insulin receptor recycling and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Zinc and Halofantrine have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and heart, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A nutritional deficiency disease that is characterized by pallor, fatigue, lightheadedness, and weakness and has material basis in low total body iron causing impaired synthesis of red blood cells.

Wikipedia : 74 Iron-deficiency anemia is anemia caused by a lack of iron. Anemia is defined as a decrease in the number... more...

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Related Diseases for Iron Deficiency Anemia

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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 660)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 35.3 TMPRSS6 HJV EPO
2 hyperferritinemia with or without cataract 31.9 TFRC TFR2 TF SLC40A1 SLC11A2 HJV
3 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 31.6 TFRC TFR2 TF SLC11A2 HJV HFE
4 thrombocytosis 31.4 THPO IL6 EPO CRP
5 celiac disease 1 31.3 TNF TFRC IL6 HFE CRP
6 polycythemia 31.1 THPO TFRC HAMP EPO
7 hemolytic anemia 30.9 TNF TFRC TF G6PD EPO
8 congestive heart failure 30.8 TNF IL6 EPO CRP
9 hypochromic microcytic anemia 30.8 TMPRSS6 TFRC TFR2 TF SLC11A2 HJV
10 thrombocytopenia 30.7 TNF THPO TFRC IL6 EPO CRP
11 beta-thalassemia 30.6 TMPRSS6 TFRC TFR2 TF HJV HFE
12 purpura 30.6 TNF THPO IL6 CRP
13 chronic kidney disease 30.6 TNF TF IL6 HAMP FGF23 EPO
14 microcytic anemia 30.6 TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2
15 alpha-thalassemia 30.6 TNF TFRC HFE G6PD EPO
16 intestinal obstruction 30.5 TNF IL6 CRP
17 iron metabolism disease 30.5 TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2
18 hemoglobinopathy 30.5 TFRC TFR2 TF HJV HFE HAMP
19 intermediate coronary syndrome 30.5 MB IL6 CRP
20 vasculitis 30.5 TNF LTF IL6 CRP
21 sickle cell anemia 30.4 TNF IL6 G6PD EPO CRP
22 thalassemia 30.4 TMPRSS6 TFRC TFR2 TF SLC40A1 HJV
23 systemic autoimmune disease 30.4 IL6 CRP
24 exanthem 30.4 TNF IL6 CRP
25 paraneoplastic syndromes 30.4 IL6 FGF23
26 gastroenteritis 30.4 TNF IL6 CRP CP
27 pulmonary tuberculosis 30.4 TNF IL6 CRP CP
28 sleep disorder 30.3 TNF IL6 CRP
29 mental depression 30.3 TNF IL6 CRP
30 anemia of prematurity 30.3 HAMP EPO
31 essential thrombocythemia 30.3 TNF THPO IL6 EPO CRP
32 aplastic anemia 30.3 TNF THPO TFRC IL6 HFE EPO
33 hemoglobinuria 30.2 THPO MB G6PD EPO
34 congenital hemolytic anemia 30.2 TFRC TF HAMP G6PD EPO
35 disseminated intravascular coagulation 30.2 TNF MB IL6 CRP
36 adult-onset still's disease 30.2 TNF IL6 CRP
37 placenta disease 30.2 TNF IL6 CRP
38 ileus 30.1 TNF IL6 CRP
39 pancytopenia 30.1 THPO IL6 EPO CRP CP
40 peripheral nervous system disease 30.1 TNF IL6 EPO CRP
41 dysentery 30.1 TNF TF IL6 CRP
42 chorioamnionitis 30.1 TNF IL6 CRP
43 varicose veins 30.1 TNF IL6 HFE
44 uremia 30.1 TNF IL6 EPO CRP
45 end stage renal disease 30.1 TNF IL6 HFE FGF23 EPO CRP
46 pulmonary disease, chronic obstructive 30.1 TNF MB IL6 CRP
47 liver cirrhosis 30.0 THPO TF HFE CP
48 proteasome-associated autoinflammatory syndrome 1 30.0 TNF IL6 CRP
49 protein-energy malnutrition 30.0 TNF TF IL6 CP
50 bronchitis 30.0 TNF LTF IL6 CRP

Comorbidity relations with Iron Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 96)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Alcoholic Liver Cirrhosis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Ascending Colon Cancer Atrophic Gastritis
Benign Essential Hypertension Bronchitis
Bronchopneumonia Cecal Benign Neoplasm
Celiac Disease 1 Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chylomicron Retention Disease
Colorectal Cancer Conjunctivitis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Duodenitis Dysthymic Disorder
Encephalopathy Esophageal Candidiasis
Esophageal Disease Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Folic Acid Deficiency Anemia Gastric Cancer
Gastrointestinal System Cancer Generalized Atherosclerosis
Gout Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypersplenism Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypoglycemic Coma Hypothyroidism
Inflammatory Bowel Disease 1 Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to Iron Deficiency Anemia
Sources

Symptoms & Phenotypes for Iron Deficiency Anemia

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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 CP CRP EPO FGF23 G6PD HEPH
2 hematopoietic system MP:0005397 10.32 CP EPO FGF23 G6PD HEPH HFE
3 homeostasis/metabolism MP:0005376 10.3 CP CRP EPO FGF23 G6PD HEPH
4 cellular MP:0005384 10.2 CP EPO G6PD HFE IL6 LTF
5 immune system MP:0005387 10.19 CP CRP EPO FGF23 HEPH HFE
6 growth/size/body region MP:0005378 10.18 FGF23 G6PD HFE IL6 MB SLC11A2
7 digestive/alimentary MP:0005381 10.03 FGF23 HEPH HFE IL6 SLC40A1 TFRC
8 integument MP:0010771 9.85 EPO FGF23 HEPH HJV IL6 SLC11A2
9 liver/biliary system MP:0005370 9.77 CP EPO HEPH HFE HJV IL6
10 mortality/aging MP:0010768 9.44 EPO FGF23 G6PD HFE HJV IL6
Sources

Drugs & Therapeutics for Iron Deficiency Anemia

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PubMed Health treatment related to Iron Deficiency Anemia: 62

Treatment for iron -deficiency anemia will depend on its cause and severity. Treatments may include dietary changes and supplements, medicines, and surgery . Severe iron -deficiency anemia may require a blood transfusion , iron injections , or intravenous (IV) iron therapy . Treatment may need to be done in a hospital. The goals of treating iron -deficiency anemia are to treat its underlying cause and restore normal levels of red blood cells , hemoglobin , and iron.

Drugs for Iron Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 192)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4 7440-66-6 32051
2
Halofantrine Approved Phase 4 69756-53-2 37393
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Copper Approved, Investigational Phase 4 7440-50-8 27099
5
Iodine Approved, Investigational Phase 4 7553-56-2 807
6
Ferrous succinate Approved Phase 4 10030-90-7
7
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
8
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
9
Tranexamic Acid Approved Phase 4 1197-18-8 5526
10
tannic acid Approved Phase 4 1401-55-4
11
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
12
Ferrous fumarate Approved Phase 4 141-01-5
13
Sodium citrate Approved, Investigational Phase 4 68-04-2
14
Iron isomaltoside 1000 Approved, Investigational Phase 4 1370654-58-2
15
Ferric maltol Approved Phase 4 33725-54-1
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
18
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
19
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
20
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 59-43-8, 70-16-6 1130
21
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
22
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
23
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
24
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
25
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
26
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
27
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
28 Tocotrienol Investigational Phase 4 6829-55-6
29 Pharmaceutical Solutions Phase 4
30 Retinol palmitate Phase 4
31 retinol Phase 4
32 Copper Supplement Phase 4
33 Tocopherols Phase 4
34 Tocotrienols Phase 4
35 cadexomer iodine Phase 4
36 Calciferol Phase 4
37 Vitamin B 6 Phase 4
38 Thiamin Phase 4
39 Nicotinic Acids Phase 4
40 Vitamin B3 Phase 4
41 Vitamin B2 Phase 4
42 Hemostatics Phase 4
43 Coagulants Phase 4
44 Antifibrinolytic Agents Phase 4
45 Lactoferrin Phase 4
46 Chelating Agents Phase 4
47 Iron Chelating Agents Phase 4
48 Antioxidants Phase 4
49 Protective Agents Phase 4
50 Neurotransmitter Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 399)
# Name Status NCT ID Phase Drugs
1 The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children Unknown status NCT01418898 Phase 4
2 A Multi-Center, Randomized, Open Label Trial to Evaluate the Utility of Serum Hepcidin Levels to Predict Response to Oral or IV Iron and Compare the Safety, Effect on Quality of Life, and Resource Utilization of Injectafer vs. Intravenous Iron Standard of Care for the Treatment of Iron Deficiency Anemia (IDA) in an Infusion Center Setting Unknown status NCT01950247 Phase 4 Injectafer;SOC
3 Multicenter Randomized Open-label Controlled Study to Investigate Treatment Response of IV Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia Secondary to Inflammatory Bowel Disease or Gastric Bypass Unknown status NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
4 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
5 Randomized, Parallel Group, Clinical Trial Comparing Intravenous Iron Sucrose Versus Oral Ferrous Sulphate in the Treatment of Perioperative Iron Deficiency in Patients With Colo-Rectal Neoplasm and Iron Deficiency Anemia. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
6 Effektivität Der in Der Schwangerschaftsvorsorge routinemässig Angewandten Eisenprophylaxe Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
7 Effectiveness of Iron Supplementation in the Second Year of Life for Prevention of Iron Deficiency Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
8 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
9 Effect of Iron Supplementation on Psychomotor Development of Non-anemic Exclusively or Predominantly Breastfed Infants: Randomized, Double-blind, Placebo-controlled Trial. Unknown status NCT02242188 Phase 4 Iron
10 The Effect of Lactoferrin Versus Iron Supplement in Treating Iron Deficiency Anemia and Helping Weight Loss in Obese School Age Children Completed NCT04014855 Phase 4 Iron Supplement
11 Lactoferrin Efficacy Versus Ferrous Sulfate in Treatment of Patients With Iron Deficiency Anemia Completed NCT04267653 Phase 4 Lactoferrin Bovine;Ferrous Sulfate
12 A Prospective, Randomized, Multi-centered Trial to Compare the Efficacy and Safety of Intravenous Iron Sucrose (Venoferrum®) With Oral Iron Acetyl-transferrin Hydroglycerin (Bolgre®) in Pregnant Women With Iron Deficiency Anemia Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
13 Ferumoxytol for Anemia of CKD Trial (FACT): A Phase IV, Open-Label, Multicenter Trial, With MRI Substudy, of Repeated Doses of Ferumoxytol Compared With Iron Sucrose for the Treatment of Iron Deficiency Anemia (IDA) in Chronic Kidney Disease (CKD) Patients on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
14 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
15 Comparison of Lactoferrin vs Traditional Iron Therapy for Treatment of Iron Deficiency Anemia in School-age Children. Completed NCT04435574 Phase 4 Lactoferrin;Ferrous Sulfate
16 Ferrous Bis-glycinate Versus Ferrous Glycine Sulfate for the Treatment of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
17 Study of KRX-0502 (Ferric Citrate) Dose Regimens in Subjects With Non-Dialysis Dependent Chronic Kidney Disease and Iron-Deficiency Anemia Completed NCT03236246 Phase 4 KRX-0502
18 Dialysis Patients' Response to IV Iron With Elevated Ferritin Completed NCT00224081 Phase 4 Sodium ferric gluconate,
19 Randomized Double-Blind Parallel Group MultiCenter Study of the Efficacy of Two Doses of Ferrlecit® in Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Receiving Epoetin. Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
20 Comparison Between Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
21 Use of FERAHEME® (Ferumoxytol) for Severe Chronic Kidney Disease and Peritoneal Dialysis Completed NCT01942460 Phase 4 Ferumoxytol
22 Low Dose Intravenous Versus Oral Iron for Iron Deficiency Anemia Starting Late in Pregnancy: A Randomized Controlled Trial Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
23 A Randomized, Controlled, Open-label Study of the Safety and Efficacy of Ferrlecit® vs Oral Iron in Iron Deficient Patients With Chronic Kidney Disease Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
24 A Randomized, Controlled, Open-label Study of the Safety and Efficacy of Ferrlecit® vs Oral Iron in Iron Deficient Patients With Chronic Kidney Disease Being Treated With Erythropoietic Therapy Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
25 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
26 FLIPS: Ferfer Liposomal Iron Performance Study Completed NCT03112187 Phase 4 Iron Supplement
27 Outcome of Oral Lactoferrin in Comparison to Amino Acid Chelated Iron and Ferrous Sulphate Supplementation During Pregnancy: A Randomized Control Trial Completed NCT03542825 Phase 4 Lactoferrin;Iron Supplement;Chelates, Iron
28 A Single-center, Double-blinded, Randomized, 12 Week, Superiority Study in Infants and Young Children to Compare the Efficacy of NovaFerrum® Versus Ferrous Sulfate in the Treatment of Nutritional Iron Deficiency Anemia. Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
29 Treatment of Anemia of Chronic Disease With True Iron Deficiency in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
30 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
31 The Efficacy and Safety of Vitamin C for Iron Supplementation Therapy in Adult Patients With Iron Deficiency Anemia(IDA) Completed NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
32 Phase IV Study of Oral Administration of Bovine Lactoferrin (bLf) to Prevent and Cure Iron Deficiency (ID) and Iron Deficiency Anemia (IDA) Until Delivery in Hereditary Thrombophilia (HT) Affected Pregnant Women Completed NCT01221844 Phase 4 FerroGrad by Abbott
33 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Completed NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
34 Diarrhea, Malaria, Anemia, and Helminthiasis Prevention Through Household-based Interventions in Rural Western Kenya: the Nyando Integrated Child Health and Education (NICHE) Project Completed NCT01088958 Phase 4
35 A Randomized Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection Completed NCT01219764 Phase 4 Rabeprazole, metronidazole, Clarithromycin, Amoxicillin
36 A Randomised Controlled Trial Comparing the Efficacy of Intravenous Iron Sucrose and Oral Iron Sulfate in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
37 The Assessment of the Minimal Effective and Tolerated Dose of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4 tranexamic acid
38 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. Randomized Clinical Trial (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
39 Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial Recruiting NCT03438227 Phase 4 Iron dextran;Ferrous sulfate 325mg
40 the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis Recruiting NCT03748043 Phase 4 Lactoferrin;Ferric Hydroxide Polymaltose
41 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
42 Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia (ACCESS): A Double-Dummy Randomized Clinical Trial Recruiting NCT03524651 Phase 4 Ferrous Sulfate;Fe-ASP;Ferrous Sulfate;Fe-ASP
43 Amino Acid Chelated Iron Versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia With Pregnancy: Randomized Controlled Trial Recruiting NCT03830034 Phase 4 Amino Acid chelated iron tab 15 mg;Ferrous Fumarate tab 350 mg( 115 mg elemental iron)
44 Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy: a Randomised, Comparative, Open-label Trial Recruiting NCT03188445 Phase 4 Iron Isomaltoside 1000;ferrous fumarate with ascorbic acid
45 Does Eradication of H-pylori in Pregnant Patients With Iron Deficiency Anemia Have an Effect on Iron Replacement Therapy? Recruiting NCT03347513 Phase 4 triple attack therapy;Ferrous(II)-glycine-sulphate complex 567.7 mg capsules
46 Effectiveness of Weekly and Daily Iron Supplementation for the Prevention of Iron-deficiency Anemia in Infants. Impact on Genomic Stability Recruiting NCT03359447 Phase 4 Weekly Ferrous Sulfate;Daily Ferrous Sulfate
47 Feraheme As An MRI Contrast Agent For Pediatric Congenital Heart Disease Recruiting NCT02752191 Phase 4 ferumoxytol;gadofosveset
48 Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With Lower Extremity Peripheral Artery Disease Recruiting NCT04083755 Phase 4 Ferric Carboxymaltose Injection [Injectafer]
49 Preoperative, Single-dose Intravenous Iron Formulation to Reduce Post-surgical Complications in Patients Undergoing Major Abdominal Surgery: a Pilot Randomised Control Trial (PIRCAS Trial - Pilot) Recruiting NCT03295851 Phase 4 Ferric carboxymaltose;Ferrous Fumarate
50 A Randomized, Double-blind Comparative Study Comparing Ferric Carboxymaltose (Ferinject) and Iron Isomaltoside 1000 (Monofer) for Iron Substitution in Iron-deficiency Anemia Active, not recruiting NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose

Search NIH Clinical Center for Iron Deficiency Anemia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ferric citrate
ferric oxide
ferric oxide yellow
Ferrous fumarate
ferrous gluconate
ferrous sulfate
FERROUS SULFATE GRANULES
FERROUS SULFATE,DRIED
Iron
Iron Carbonyl
iron sucrose
IRON SUMALATE
IRON,PEPTONIZED
Iron-Dextran Complex
Polysaccharide iron complex
Sodium ferric gluconate complex
Sources

Genetic Tests for Iron Deficiency Anemia

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Genetic tests related to Iron Deficiency Anemia:

# Genetic test Affiliating Genes
1 Iron Deficiency Anemia 29
Sources

Anatomical Context for Iron Deficiency Anemia

About this section

MalaCards organs/tissues related to Iron Deficiency Anemia:

40
Kidney, Testes, Heart, Bone, Liver, Colon, Bone Marrow
Sources

Publications for Iron Deficiency Anemia

About this section

Articles related to Iron Deficiency Anemia:

(show top 50) (show all 7118)
# Title Authors PMID Year
1
Human transferrin G277S mutation and iron deficiency in pregnancy. 6
16398662 2006
2
The G277S mutation in transferrin does not disturb function. 6
12752114 2003
3
Human transferrin G277S mutation: a risk factor for iron deficiency anaemia. 6
11703331 2001
4
Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. 61 54
20407805 2010
5
[Soluble tranferrin receptor in the biological diagnosis of iron deficiency. Report of 24 cases]. 54 61
20209848 2009
6
Iron-refractory iron deficiency anemia: new molecular mechanisms. 61 54
19776721 2009
7
Food insecurity is associated with iron deficiency anemia in US adolescents. 61 54
19776137 2009
8
Concomitant severe normocytic and normochromic anemia in poststreptococcal acute glomerulonephritis. 61 54
19915313 2009
9
Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms. 61 54
19592582 2009
10
Is soluble transferrin receptor a good marker of iron deficiency anemia in chronic kidney disease patients? 54 61
20436728 2009
11
Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia. 54 61
19357398 2009
12
Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study. 54 61
19639462 2009
13
[Density-specific distribution of erythrocytes in different types of anemia]. 61 54
19253711 2009
14
Nutritional consequences of adjustable gastric banding and gastric bypass: a 1-year prospective study. 61 54
18542847 2009
15
Characterization and differentiation of iron status in anemic very low birth weight infants using a diagnostic nomogram. 54 61
18776731 2009
16
Unexplained decline in the prevalence of anemia among US children and women between 1988-1994 and 1999-2002. 54 61
19064522 2008
17
Safety issues with intravenous iron products in the management of anemia in chronic kidney disease. 61 54
19325171 2008
18
A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. 61 54
18603562 2008
19
Weekly training volume and hematological status in female top-level athletes of different sports. 61 54
18974729 2008
20
Serum pro-hepcidin as an indicator of iron status in dialysis patients. 61 54
18503700 2008
21
Iron deficiency in young Lebanese children: association with elevated blood lead levels. 61 54
18458574 2008
22
Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease. 61 54
18477354 2008
23
Preventive effect of lactoferrin intake on anemia in female long distance runners. 54 61
18391460 2008
24
Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. 61 54
18446719 2008
25
Iron fortification: its efficacy and safety in relation to infections. 54 61
18297896 2007
26
Features of iron deficiency anemia without increment in soluble transferrin receptor concentration. 54 61
17315212 2007
27
[The expression of TfR1 mRNA and IRP1 mRNA in the placenta from different maternal iron status]. 61 54
17877204 2007
28
[The comparison of diagnostic usefulness of transferrin determination by immunological and chemical method in iron deficiency anemia]. 61 54
17682669 2007
29
Prevalence of iron deficiency and anemia among healthy women of reproductive age in Bhaktapur, Nepal. 54 61
16929243 2007
30
Nonhematological benefits of iron. 61 54
17804903 2007
31
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice. 61 54
17003376 2007
32
[Study on serum erythropoietin levels in patients with hematologic malignancies]. 54 61
17172129 2006
33
Adjusting i.v. iron and EPO doses in patients on hemodialysis prior to continuing surgery: can we protect our patients education from iron-deficiency anemia? 61 54
17002001 2006
34
The interaction between heart failure and other heart diseases, renal failure, and anemia. 61 54
16949468 2006
35
Gastric antral vascular ectasia (watermelon stomach) in patients with ESRD. 54 61
16731286 2006
36
Iron indices: what do they really mean? 54 61
16830699 2006
37
Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency. 61 54
16503547 2006
38
Carbohydrate-deficient isoforms of transferrin (%CDT) and sialic acid (SA) in iron-deficiency anemia. 61 54
16178908 2005
39
Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia. 54 61
15820481 2005
40
Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children. 54 61
15755831 2005
41
Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis. 54 61
15843240 2005
42
Comparison of the serum erythropoietin levels in chemotherapy-naive and cisplatin-treated cancer patients. 54 61
15739025 2005
43
The soluble transferrin receptor (sTfR)-ferritin index is a potential predictor of celiac disease in children with refractory iron deficiency anemia. 54 61
15653440 2005
44
Iron status of the Taiwanese elderly: the prevalence of iron deficiency and elevated iron stores. 61 54
16169840 2005
45
Serum transferrin receptor levels in beta-thalassemia trait. 54 61
15537726 2004
46
Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method. 61 54
15531698 2004
47
Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. 61 54
15222487 2004
48
Factors associated with iron deficiency anemia in Brazilian preschool children. 61 54
15192767 2004
49
[Conventional and new laboratory parameters in the evaluation of hematologic disease]. 61 54
15018392 2004
50
Prevalence of iron depletion and anemia in top-level basketball players. 54 61
15129928 2004
Sources

Variations for Iron Deficiency Anemia

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ClinVar genetic disease variations for Iron Deficiency Anemia:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TF NM_001063.4(TF):c.829G>A (p.Gly277Ser)SNV Benign 12622 rs1799899 3:133475812-133475812 3:133756968-133756968
Sources

Expression for Iron Deficiency Anemia

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Search GEO for disease gene expression data for Iron Deficiency Anemia.
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Pathways for Iron Deficiency Anemia

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Pathways related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Insulin receptor recycling 65
Show member pathways
 12.25 TFRC TF SLC40A1 SLC11A2 HEPH CP
2
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.86 TNF THPO IL6 EPO
3
HIF-1 signaling pathway 36
11.82 TFRC TF IL6 EPO
4
Metal ion SLC transporters 65
Show member pathways
 11.74 SLC40A1 SLC11A2 HEPH CP
5
Hematopoietic cell lineage 36
11.65 TNF THPO TFRC IL6 EPO
6
HIF-1-alpha transcription factor network 1
11.52 TFRC TF EPO CP
7
Mineral absorption 36
11.43 TF SLC40A1 SLC11A2 HEPH
8
Differentiation Pathway 1
11.37 TF IL6 EPO
9
Ferroptosis 36
11.17 TFRC TF SLC40A1 SLC11A2 CP
10
Overview of nanoparticle effects 1
10.89 TNF IL6 CRP
11
Iron metabolism in placenta 1
10.18 TFRC TFR2 TF SLC40A1 SLC11A2 HAMP
12
Hfe effect on hepcidin production 1
10.1 TMPRSS6 HJV HFE HAMP
Sources

GO Terms for Iron Deficiency Anemia

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Cellular components related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.14 TNF THPO TFRC TF LTF IL6
2 extracellular space GO:0005615 10 TNF TMPRSS6 THPO TFRC TF LTF
3 cell surface GO:0009986 9.91 TNF TFRC TF SLC11A2 LTF HJV
4 recycling endosome GO:0055037 9.65 TNF TFRC TF SLC11A2 HFE
5 basal part of cell GO:0045178 9.5 TF SLC11A2 HFE
6 cell GO:0005623 9.47 TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2
7 HFE-transferrin receptor complex GO:1990712 9.35 TFRC TFR2 TF HJV HFE

Biological processes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.05 TF SLC40A1 SLC11A2 LTF HFE HEPH
2 positive regulation of gene expression GO:0010628 10.02 TNF TFRC IL6 HFE CRP
3 cellular protein metabolic process GO:0044267 9.92 TF LTF IL6 FGF23 CP
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 TNF THPO FGF23 EPO
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TFRC LTF IL6
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.8 TNF TFRC IL6
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 TNF IL6 EPO
8 humoral immune response GO:0006959 9.76 TNF LTF IL6
9 acute-phase response GO:0006953 9.73 TFR2 IL6 HFE HAMP EPO CRP
10 osteoclast differentiation GO:0030316 9.71 TNF TFRC TF
11 transferrin transport GO:0033572 9.71 TFRC TFR2 TF HFE
12 iron ion transport GO:0006826 9.7 TFRC TFR2 TF SLC40A1 SLC11A2 HEPH
13 copper ion transport GO:0006825 9.67 SLC11A2 HEPH CP
14 response to iron ion GO:0010039 9.67 TFR2 SLC11A2 HFE HAMP
15 negative regulation of lipid storage GO:0010888 9.65 TNF IL6 CRP
16 iron ion homeostasis GO:0055072 9.65 TMPRSS6 TFR2 TF SLC40A1 SLC11A2 LTF
17 iron ion transmembrane transport GO:0034755 9.63 TF SLC40A1 SLC11A2
18 positive regulation of neuroinflammatory response GO:0150078 9.62 TNF IL6
19 multicellular organismal iron ion homeostasis GO:0060586 9.62 SLC40A1 SLC11A2 HFE HAMP
20 response to salt stress GO:0009651 9.61 TNF EPO
21 cellular response to iron ion GO:0071281 9.61 TFR2 TF HFE
22 positive regulation of peptide hormone secretion GO:0090277 9.6 TFR2 HFE
23 negative regulation by host of viral process GO:0044793 9.57 LTF CRP
24 response to iron ion starvation GO:1990641 9.56 HFE HAMP
25 regulation of iron ion transport GO:0034756 9.55 TF HFE
26 cellular iron ion homeostasis GO:0006879 9.36 TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2

Molecular functions related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 TNF THPO IL6 EPO
2 iron ion transmembrane transporter activity GO:0005381 9.32 SLC40A1 SLC11A2
3 ferroxidase activity GO:0004322 9.26 HEPH CP
4 ferrous iron transmembrane transporter activity GO:0015093 9.16 SLC40A1 SLC11A2
5 transferrin receptor activity GO:0004998 8.96 TFRC TFR2
6 transferrin receptor binding GO:1990459 8.8 TF HJV HFE
Sources

Sources for Iron Deficiency Anemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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