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MCID: IRN001
MIFTS: 55

Iron Deficiency Anemia

Categories: Immune diseases, Blood diseases, Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Iron Deficiency Anemia

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MalaCards integrated aliases for Iron Deficiency Anemia:

Name: Iron Deficiency Anemia 12 29 55 6 15 73
Iron-Deficiency Anemia 63

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11758
ICD9CM 35 280.8
ICD10 33 D50
Sources

Summaries for Iron Deficiency Anemia

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PubMed Health : 63 About iron-deficiency anemia: Iron-deficiency anemia is a common, easily treated condition that occurs if you don't have enough iron in your body. Low iron levels usually are due to blood loss, poor diet, or an inability to absorb enough iron from food.

MalaCards based summary : Iron Deficiency Anemia, also known as iron-deficiency anemia, is related to iron-refractory iron deficiency anemia and microcytic anemia. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways are Insulin receptor recycling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Iron and Zinc have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Iron-deficiency anemia is anemia caused by a lack of iron. Anemia is defined as a decrease in the number... more...

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Related Diseases for Iron Deficiency Anemia

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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.7 EPO HJV TMPRSS6
2 microcytic anemia 32.0 EPO SLC11A2 TF TFRC TMPRSS6
3 thalassemia 30.8 EPO HFE TF TFRC
4 hemoglobinopathy 30.6 EPO HAMP TF
5 hyperferritinemia with or without cataract 30.5 HFE TF
6 restless legs syndrome 30.3 EPO SLC11A2 TFRC
7 hypochromic microcytic anemia 30.3 SLC11A2 TF TMPRSS6
8 polycythemia 30.2 EPO TFRC THPO
9 castleman disease 30.0 CRP IL6
10 intussusception 29.8 CRP IL6
11 thrombocytosis 29.7 CRP EPO IL6 THPO
12 iron metabolism disease 29.5 EPO HFE HJV SLC11A2 SLC40A1 TF
13 kidney disease 29.3 CRP EPO FGF23 TF
14 beta-thalassemia 29.1 EPO HAMP HFE TF TFR2 TFRC
15 malaria 28.7 CRP EPO HAMP IL6 TFRC
16 hemosiderosis 28.3 EPO HAMP HFE SLC11A2 SLC40A1 TF
17 chronic kidney failure 28.2 CRP EPO FGF23 IL6 TF
18 hemochromatosis, type 1 26.3 HAMP HFE HJV SLC11A2 SLC40A1 TF
19 deficiency anemia 25.3 CRP EPO HAMP HFE HJV IL6
20 plummer vinson syndrome 11.3
21 gastric antral vascular ectasia 11.3
22 autoimmune atrophic gastritis 11.3
23 anemia, congenital dyserythropoietic, type iii 11.0
24 ancylostomiasis 11.0
25 hemochromatosis, type 2a 10.7 HAMP HJV
26 iron overload in africa 10.7 HFE TF
27 splenic disease 10.7 EPO THPO
28 fetal erythroblastosis 10.5 EPO TFRC
29 melancholia 10.5 CRP TF
30 angiomatous meningioma 10.5 TF TFRC
31 hemoglobin h disease 10.5 EPO TF TFRC
32 pure red-cell aplasia 10.5 EPO TF
33 vibrio vulnificus infection 10.4 EPO IL6
34 aging 10.4
35 arteriovenous fistula 10.4 EPO IL6
36 hemochromatosis, type 3 10.4 HFE TFR2
37 analbuminemia 10.3 CRP EPO TF
38 hypersplenism 10.3 EPO THPO
39 acute monoblastic leukemia 10.3 EPO IL6
40 uremia 10.3 CRP EPO TF
41 poems syndrome 10.3 EPO IL6
42 celiac disease 1 10.3
43 inflammatory bowel disease 10.3
44 tenosynovitis 10.2 CRP SLC40A1
45 helicobacter pylori infection 10.2
46 hemochromatosis, type 4 10.2 SLC40A1 TFR2
47 thrombosis 10.2
48 liver cirrhosis 10.2 HFE TF THPO
49 cold agglutinin disease 10.2 CRP IL6
50 pulmonary hemosiderosis 10.2

Comorbidity relations with Iron Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 99)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Alcoholic Liver Cirrhosis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Ascending Colon Cancer Atrophic Gastritis
Benign Essential Hypertension Bronchitis
Bronchopneumonia Cecal Benign Neoplasm
Celiac Disease 1 Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chronic Kidney Failure
Chronic Myocardial Ischemia Chylomicron Retention Disease
Colorectal Cancer Conjunctivitis
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Duodenitis Dysthymic Disorder
Encephalopathy Esophageal Candidiasis
Esophageal Disease Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Folic Acid Deficiency Anemia Gastric Cancer
Gastrointestinal System Cancer Generalized Atherosclerosis
Gout Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypersplenism Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypoglycemic Coma Hypothyroidism

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to Iron Deficiency Anemia
Sources

Symptoms & Phenotypes for Iron Deficiency Anemia

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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 HFE SLC40A1 HJV EPO IL6 FGF23
2 homeostasis/metabolism MP:0005376 10.13 HFE SLC40A1 HJV CRP EPO IL6
3 cardiovascular system MP:0005385 10.11 SLC11A2 SLC40A1 HJV CRP EPO IL6
4 growth/size/body region MP:0005378 10.06 FGF23 SLC11A2 HFE IL6 TFRC SLC40A1
5 immune system MP:0005387 10.03 HFE SLC40A1 HJV CRP EPO IL6
6 digestive/alimentary MP:0005381 9.91 HFE IL6 FGF23 TFRC SLC40A1 TMPRSS6
7 integument MP:0010771 9.76 SLC11A2 SLC40A1 HJV EPO IL6 FGF23
8 liver/biliary system MP:0005370 9.61 HFE SLC40A1 HJV EPO IL6 SLC11A2
9 mortality/aging MP:0010768 9.32 SLC11A2 HFE SLC40A1 HJV EPO IL6
Sources

Drugs & Therapeutics for Iron Deficiency Anemia

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PubMedHealth treatment related to Iron Deficiency Anemia: 63

Treatment for iron-deficiency anemia will depend on its cause and severity. Treatments may include dietary changes and supplements, medicines, and surgery.Severe iron-deficiency anemia may require a blood transfusion, iron injections, or intravenous (IV) iron therapy. Treatment may need to be done in a hospital.The goals of treating iron-deficiency anemia are to treat its underlying cause and restore normal levels of red blood cells, hemoglobin, and iron.

Drugs for Iron Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 266)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6 23925
2
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 7440-66-6 23994
3
Halofantrine Approved Phase 4 69756-53-2 37393
4
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 44475014
5
Copper Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-50-8 27099
6
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
7
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7782-49-2
8
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
9
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
10
Clarithromycin Approved Phase 4 81103-11-9 84029
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 11103-57-4, 68-26-8 445354
13
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 5785 54670067
14
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
15
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 68-19-9 44176380
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
18
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 13422-55-4
19
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 59-67-6 938
20
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 98-92-0 936
21
Pyridoxal Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 66-72-8 1050
22
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 65-23-6 1054
23
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 83-88-5 493570
24
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
25
Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 1,Not Applicable 1406-66-2 14986
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
27
Vitamin D3 Approved, Nutraceutical Phase 4,Not Applicable 67-97-0 6221 5280795
28
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 59-02-9 14985
29
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
30
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
31 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Ferric oxide, saccharated Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Hematinics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
34 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Teferrol Phase 4,Phase 3,Not Applicable
37 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Ferrous fumarate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
40 Ferrous gluconate Phase 4,Phase 1,Not Applicable
41 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
42 Epoetin alfa Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113427-24-0
43 ferric gluconate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Hepcidins Phase 4,Phase 1,Phase 2,Not Applicable
45 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Blood Substitutes Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Dextrans Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Iron-Dextran Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Plasma Substitutes Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 567)
# Name Status NCT ID Phase Drugs
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
3 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
4 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
5 Iron Deficiency In Pulmonary Hypertension Unknown status NCT01288651 Phase 4 Ferricarboxymaltose
6 Optimizing Iron Suppletion After Roux-en-Y Gastric Bypass Unknown status NCT02271997 Phase 4 Ferrous fumarate;Ferrous gluconate;Iron(III)carboxymaltose
7 Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance In Non Anemic Premenopausal Women With Low Ferritin Levels Unknown status NCT01374776 Phase 4 Double blind, randomized, placebo controlled inter
8 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
9 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
10 Iron Absorption Trial Unknown status NCT02228902 Phase 4 Ferrous fumarate;Ferrous gluconate
11 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
12 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
13 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
14 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
15 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
16 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Completed NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
17 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
18 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
19 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
20 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
21 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
22 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
23 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
24 Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
25 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
26 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
27 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
28 Iron Substitution in Blood Donors Completed NCT01519830 Phase 4 Iron carboxymaltose (Ferinject);Placebo
29 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
30 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
31 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
32 Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age Completed NCT01110356 Phase 4 Ferinject
33 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
34 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
35 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
36 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
37 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
38 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
39 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
40 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
41 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
42 Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study) Completed NCT01609387 Phase 4
43 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
44 Periodic Versus Continuous IV Iron Supplementation in HD Patients Completed NCT02787824 Phase 4 Iron Sucrose Supplement
45 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
46 Vitamin B12 Pregnancy Supplementation Completed NCT03522428 Phase 4
47 The Use of Liposomated Iron After Bariatric Surgery in Patients That Are Receiving Parentheral Therapy With Iron Completed NCT02390921 Phase 4 Fisiogen Ferro Forte;Venofer
48 Prenatal Iron and Malaria Study Completed NCT01308112 Phase 4
49 Small Bowel Cleansing Prior to Video Capsule Endoscopy Examination Completed NCT00677794 Phase 4 Clear fluids;Picosalax;Polyethylene glycol
50 Effect of Iron Therapy as an Adjunct to Epoetin Alfa in the Anemia of Cancer Chemotherapy Completed NCT00224068 Phase 4 Sodium ferric gluconate, ferrous sulfate, standard of care

Search NIH Clinical Center for Iron Deficiency Anemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Iron Deficiency Anemia

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Genetic tests related to Iron Deficiency Anemia:

# Genetic test Affiliating Genes
1 Iron Deficiency Anemia 29
Sources

Anatomical Context for Iron Deficiency Anemia

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MalaCards organs/tissues related to Iron Deficiency Anemia:

41
Kidney, Heart, Testes, Brain, Skeletal Muscle, Liver, Bone
Sources

Publications for Iron Deficiency Anemia

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Articles related to Iron Deficiency Anemia:

(show top 50) (show all 820)
# Title Authors Year
1
Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia. ( 29795991 )
2018
2
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
3
Protein-Losing Enteropathy in the Setting of Severe Iron Deficiency Anemia. ( 29511696 )
2018
4
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma. ( 29955854 )
2018
5
Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood are Associated with Behavior Problems in Adolescent Boys: Results from the BogotA! School Children Cohort. ( 29897579 )
2018
6
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis. ( 29499633 )
2018
7
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs. ( 29772815 )
2018
8
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
9
A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review. ( 29851802 )
2018
10
Cooking in Iron Pots for Iron Deficiency Anemia: The Traditional Way Forward? ( 29948738 )
2018
11
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
12
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
13
Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen. ( 29850236 )
2018
14
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
15
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
16
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
17
A comment on the comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia. ( 29981266 )
2018
18
Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia. ( 29868633 )
2018
19
Efficacy of ferrous bis-glycinate versus ferrous glycine sulfate in the treatment of iron deficiency anemia with pregnancy: a randomized double-blind clinical trial. ( 29843553 )
2018
20
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
21
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
22
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
23
The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia. ( 29928945 )
2018
24
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
25
Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis. ( 29767699 )
2018
26
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
27
Iron Deficiency Anemia with Menorrhagia: Ferric Carboxymaltose a Safer Alternative to Blood Transfusion. ( 29962808 )
2018
28
New Onset Iron Deficiency Anemia in Chronic Therapeutic Plasma Exchange Patients. ( 29970428 )
2018
29
Relation between Depressive Disorder and Iron Deficiency Anemia among Adults Reporting to a Secondary Healthcare Facility: A Hospital-Based Case Control Study. ( 29848423 )
2018
30
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial. ( 29917215 )
2018
31
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
32
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
33
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
34
Effects of an enhanced iron dense foods offering in the daily meals served in geriatric institutions on measures of iron deficiency anemia. ( 29801478 )
2018
35
Usefulness of Oral Ferric Citrate in Patients With Iron-Deficiency Anemia and Chronic Kidney Disease With or Without Heart Failure. ( 29961562 )
2018
36
A Toddler With Treatment-Resistant Iron Deficiency Anemia. ( 29950397 )
2018
37
Effect of dietary intervention treatment on children with iron deficiency anemia in China: a meta-analysis. ( 29747646 )
2018
38
Correction to: Carvalho et al., Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease. ( 28853335 )
2017
39
Reply: Intravenous Ferumoxytol in Pediatric Patients With Iron-Deficiency Anemia. ( 28831808 )
2017
40
Cerebral Venous Thrombosis in a Patient with Iron Deficiency Anemia and Thrombocytopenia: A Case Report. ( 29362628 )
2017
41
VON WILLEBRAND FACTOR IMMUNOHISTOCHEMICAL STAINING QUANTITATIVE OPTICAL DENSITY PARAMETERS IN THE ENDOTHELIUM AND FIBRINOID OF THE PLACENTA DURING SECUNDINES INFLAMMATION AND CONCOMITANT IRON DEFICIENCY ANEMIA IN GRAVIDAS. ( 29328041 )
2017
42
Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia. ( 29282766 )
2017
43
The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease. ( 29023457 )
2017
44
Phase III randomized trial comparing intravenous to oral iron in patients with cancer-related iron deficiency anemia not on erythropoiesis stimulating agents. ( 28849623 )
2017
45
Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. ( 28460265 )
2017
46
New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia. ( 28934514 )
2017
47
A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia. ( 28052413 )
2017
48
Idiopathic Pulmonary Hemosiderosis Mimicking Iron Deficiency Anemia: A Delayed Diagnosis? ( 28670434 )
2017
49
Challenges in the diagnosis of iron deficiency anemia in aged people. ( 28830594 )
2017
50
Author's reply: Directly observed iron supplementation for control of iron deficiency anemia. ( 28928309 )
2017
Sources

Variations for Iron Deficiency Anemia

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Sources

Expression for Iron Deficiency Anemia

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Search GEO for disease gene expression data for Iron Deficiency Anemia.
Sources

Pathways for Iron Deficiency Anemia

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Pathways related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Insulin receptor recycling 66
Show member pathways
 12.2 SLC11A2 SLC40A1 TF TFRC
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.72 EPO IL6 THPO
3
HIF-1 signaling pathway 37
11.62 EPO IL6 TF TFRC
4
Hematopoietic cell lineage 37
11.54 EPO IL6 TFRC THPO
5
HIF-1-alpha transcription factor network 1
11.42 EPO TF TFRC
6
Mineral absorption 37
11.29 SLC11A2 SLC40A1 TF
7
Differentiation Pathway 1
11.23 EPO IL6 TF
8
Ferroptosis 37
11.06 SLC11A2 SLC40A1 TF TFRC
9
Overview of nanoparticle effects 1
10.77 CRP IL6
10
Iron metabolism in placenta 1
10.18 HAMP SLC11A2 SLC40A1 TF TFR2 TFRC
11
Hfe effect on hepcidin production 1
10.1 HAMP HFE HJV TMPRSS6
Sources

GO Terms for Iron Deficiency Anemia

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Cellular components related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CRP EPO FGF23 HAMP IL6 TF
2 cytoplasmic vesicle GO:0031410 9.83 HFE SLC11A2 TF TFR2 TFRC
3 cell surface GO:0009986 9.8 EPO HJV SLC11A2 TF TFRC
4 extracellular space GO:0005615 9.7 CRP EPO FGF23 HAMP HFE HJV
5 early endosome GO:0005769 9.62 HFE SLC11A2 TF TFRC
6 recycling endosome GO:0055037 9.56 HFE SLC11A2 TF TFRC
7 basal part of cell GO:0045178 9.33 HFE SLC11A2 TF
8 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC

Biological processes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.91 EPO FGF23 HAMP IL6 THPO
2 transferrin transport GO:0033572 9.71 HFE TF TFR2 TFRC
3 response to iron ion GO:0010039 9.67 HAMP HFE SLC11A2 TFR2
4 acute-phase response GO:0006953 9.63 CRP EPO HAMP HFE IL6 TFR2
5 iron ion transport GO:0006826 9.62 SLC11A2 SLC40A1 TF TFR2
6 cellular response to iron ion GO:0071281 9.61 HFE TF TFR2
7 positive regulation of receptor-mediated endocytosis GO:0048260 9.57 HFE TF
8 response to vitamin A GO:0033189 9.56 EPO HAMP
9 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A2 SLC40A1
10 cellular response to interleukin-6 GO:0071354 9.55 FGF23 HAMP
11 negative regulation of lipid storage GO:0010888 9.54 CRP IL6
12 positive regulation of peptide hormone secretion GO:0090277 9.52 HFE TFR2
13 iron ion homeostasis GO:0055072 9.5 HFE HJV SLC11A2 SLC40A1 TF TFR2
14 iron ion import GO:0097286 9.49 TFR2 TFRC
15 regulation of iron ion import GO:1900390 9.48 HFE TF
16 response to iron ion starvation GO:1990641 9.46 HAMP HFE
17 cellular iron ion homeostasis GO:0006879 9.28 HAMP HFE HJV SLC11A2 SLC40A1 TF

Molecular functions related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.61 FGF23 IL6 THPO
2 hormone activity GO:0005179 9.58 EPO HAMP THPO
3 co-receptor binding GO:0039706 9.37 HFE TFR2
4 iron ion transmembrane transporter activity GO:0005381 9.32 SLC11A2 SLC40A1
5 ferrous iron transmembrane transporter activity GO:0015093 9.26 SLC11A2 SLC40A1
6 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
7 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
8 transferrin receptor binding GO:1990459 8.8 HFE HJV TF
Sources

Sources for Iron Deficiency Anemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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