Iron Deficiency Anemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IRN001 MIFTS: 59	Iron Deficiency Anemia Categories: Blood diseases, Immune diseases, Metabolic diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Iron Deficiency Anemia

MalaCards integrated aliases for Iron Deficiency Anemia:

Name: Iron Deficiency Anemia ¹¹ ²⁸ ⁵³ ⁵ ¹⁴ ⁷¹

Iron-Deficiency Anemia ⁶³ ⁷⁵

Fe - [iron] Deficiency Anemia Nos ³³

Ida - [iron Deficiency Anemia] ³³

Fe Deficiency Anaemia ³³

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Nutritional anaemias

Iron deficiency anaemia

Iron deficiency anaemia, unspecified

ICD11: ³³

Diseases of the blood or blood-forming organs

Anaemias or other erythrocyte disorders

Nutritional or metabolic anaemias

Iron deficiency anaemia

Iron deficiency anaemia, unspecified

Other specified iron deficiency anaemia

External Ids:

Disease Ontology ¹¹ DOID:11758

ICD9CM ³⁴ 280.8

SNOMED-CT ⁶⁸ 191129007

ICD10 ³¹ D50 D50.9

ICD11 ³³ 1577750667 1577750667/other 1577750667/unspecified

UMLS ⁷¹ C0029810 C0162316

Sources

Summaries for Iron Deficiency Anemia

PubMed Health : ⁶³ Iron-deficiency anemia: Iron-deficiency anemia is a common, easily treated condition that occurs if you don't have enough iron in your body. Low iron levels usually are due to blood loss, poor diet, or an inability to absorb enough iron from food.

MalaCards based summary: Iron Deficiency Anemia, also known as iron-deficiency anemia, is related to iron-refractory iron deficiency anemia and celiac disease 1. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Disorders of transmembrane transporters. The drugs Tocopherol and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart, and related phenotypes are homeostasis/metabolism and liver/biliary system

Disease Ontology: ¹¹ A nutritional deficiency disease that is characterized by pallor, fatigue, lightheadedness, and weakness and has material basis in low total body iron causing impaired synthesis of red blood cells.

Wikipedia: ⁷⁵ Iron-deficiency anemia is anemia caused by a lack of iron. Anemia is defined as a decrease in the number... more...

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Related Diseases for Iron Deficiency Anemia

Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)

#	Related Disease	Score	Top Affiliating Genes
1	iron-refractory iron deficiency anemia	33.7	TMPRSS6 HJV
2	celiac disease 1	31.6	TNF TFRC IL6 HFE CRP
3	thrombocytosis	31.5	THPO IL6 EPO CRP
4	bowel dysfunction	31.5	TNF LTF IL6 CRP
5	thalassemia minor	31.4	HBG2 HAMP EPO
6	iron metabolism disease	31.4	TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2
7	microcytic anemia	31.3	TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2
8	chronic kidney disease	31.2	TNF TF IL6 EPO CRP
9	vitamin b12 deficiency	31.2	HAMP EPO CRP
10	peptic ulcer disease	31.1	TNF IL6 CRP
11	hemorrhoid	31.1	TNF IL6 CRP
12	restless legs syndrome	31.1	TFRC SLC11A2 HAMP FTL EPO
13	sickle cell disease	30.9	HBG2 G6PD EPO
14	nutritional deficiency disease	30.9	TMPRSS6 TFRC TF SLC11A2 IL6 HJV
15	thrombocytopenia	30.9	TNF THPO TFRC IL6 EPO CRP
16	kidney disease	30.9	TNF TF IL6 HFE HAMP EPO
17	crohn's disease	30.8	TNF LTF IL6 CRP
18	polycythemia	30.8	THPO TFRC HAMP EPO CRP
19	thalassemia	30.8	TMPRSS6 TFRC TFR2 TF SLC40A1 HJV
20	intracranial hypertension	30.8	TNF IL6 CRP
21	purpura	30.7	TNF THPO IL6 CRP
22	gastroenteritis	30.7	TNF IL6 CRP CP
23	anemia, sideroblastic, 1	30.7	TMPRSS6 TFRC TFR2 SLC40A1 SLC11A2 HJV
24	iron overload	30.7	TFR2 TF SLC40A1 SLC11A2 HJV HFE
25	asphyxia neonatorum	30.7	IL6 EPO CRP
26	urinary tract infection	30.7	TNF IL6 CRP
27	aplastic anemia	30.6	TNF THPO TFRC IL6 EPO
28	folic acid deficiency anemia	30.6	HAMP EPO CRP
29	lactose intolerance	30.6	TNF IL6 CRP
30	pouchitis	30.6	TNF LTF
31	hypochromic microcytic anemia	30.6	TMPRSS6 TFRC TF SLC40A1 SLC11A2 HJV
32	adult syndrome	30.6	TNF IL6 CRP
33	alpha-thalassemia	30.6	TNF TMPRSS6 TFRC HFE HBG2 HAMP
34	vasculitis	30.6	TNF LTF IL6 CRP
35	intestinal obstruction	30.6	TNF IL6 CRP
36	common cold	30.6	TNF IL6 CRP
37	chronic fatigue syndrome	30.6	TNF IL6 CRP
38	liver cirrhosis	30.5	TNF THPO TF IL6 HFE
39	exanthem	30.5	TNF IL6 CRP
40	hemoglobinuria	30.5	THPO G6PD EPO
41	sickle cell anemia	30.5	TNF TFRC IL6 HBG2 HAMP G6PD
42	deficiency anemia	30.5	TNF TMPRSS6 THPO TFRC TFR2 TF
43	alcohol use disorder	30.5	TNF TF IL6 HFE CRP
44	thyroiditis	30.5	TNF IL6 CRP
45	fibromyalgia	30.5	TNF IL6 CRP
46	anemia of prematurity	30.5	TFRC HAMP EPO
47	pulmonary tuberculosis	30.5	TNF IL6 CRP CP
48	sleep disorder	30.4	TNF IL6 CRP
49	hemolytic anemia	30.4	TMPRSS6 TFRC TF HFE HBG2 HAMP
50	substance abuse	30.4	TNF TF IL6 CRP

Comorbidity relations with Iron Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 97)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Acute Pancreatitis
Alcoholic Liver Cirrhosis	Alzheimer Disease, Familial, 1
Anxiety	Aortic Valve Disease 1
Ascending Colon Cancer	Atrophic Gastritis
Benign Essential Hypertension	Bronchitis
Bronchopneumonia	Cecal Benign Neoplasm
Celiac Disease 1	Cerebral Atherosclerosis
Cerebral Degeneration	Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency	Chronic Kidney Disease
Chylomicron Retention Disease	Colorectal Cancer
Conjunctivitis	Cystitis
Decubitus Ulcer	Deficiency Anemia
Dermatomycosis	Duodenitis
Dysthymic Disorder	Encephalopathy
Esophageal Candidiasis	Esophageal Disease
Esophagitis	Familial Atrial Fibrillation
First-Degree Atrioventricular Block	Folic Acid Deficiency Anemia
Gastric Cancer	Gastrointestinal System Cancer
Generalized Atherosclerosis	Gout
Heart Disease	Hepatic Flexure Cancer
Hydronephrosis	Hypersplenism
Hypertension, Essential	Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia	Hypoglycemic Coma
Hypothyroidism	Inflammatory Bowel Disease 1

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:

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Symptoms & Phenotypes for Iron Deficiency Anemia

GenomeRNAi Phenotypes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.11	CP CRP EPO FTL G6PD HAMP
2	no effect	GR00402-S-2	10.11	CP CRP EPO FTL HBG2 HEPH

MGI Mouse Phenotypes related to Iron Deficiency Anemia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.41	CP CRP EPO FTL G6PD HAMP
2	liver/biliary system	MP:0005370	10.33	CP EPO FTL HAMP HEPH HFE
3	nervous system	MP:0003631	10.29	CP FTL G6PD HEPH HFE HJV
4	growth/size/body region	MP:0005378	10.22	CP FTL G6PD HAMP HFE IL6
5	immune system	MP:0005387	10.21	CP CRP EPO FTL G6PD HAMP
6	cardiovascular system	MP:0005385	10.2	CP CRP EPO FTL G6PD HEPH
7	hematopoietic system	MP:0005397	10.11	CP EPO FTL G6PD HAMP HEPH
8	digestive/alimentary	MP:0005381	9.97	HEPH HFE IL6 SLC40A1 TFR2 TFRC
9	mortality/aging	MP:0010768	9.8	EPO FTL G6PD HAMP HFE HJV
10	integument	MP:0010771	9.28	HEPH HJV IL6 SLC11A2 SLC40A1 TF

Sources

Drugs & Therapeutics for Iron Deficiency Anemia

PubMed Health treatment related to Iron Deficiency Anemia: ⁶³

Treatment for iron -deficiency anemia will depend on its cause and severity. Treatments may include dietary changes and supplements, medicines, and surgery . Severe iron -deficiency anemia may require a blood transfusion , iron injections , or intravenous (IV) iron therapy . Treatment may need to be done in a hospital. The goals of treating iron -deficiency anemia are to treat its underlying cause and restore normal levels of red blood cells , hemoglobin , and iron.

Drugs for Iron Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tocopherol

Approved, Investigational

Phase 4

1406-66-2

Esomeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6, 119141-88-7

9568614 4594

Clarithromycin

Approved

Phase 4

81103-11-9

84029

Metronidazole

Approved

Phase 4

443-48-1, 69198-10-3

4173

Zinc cation

Approved, Experimental, Investigational

Phase 4

7440-66-6, 23713-49-7

32051

Copper

Approved, Investigational

Phase 4

7440-50-8

27099

Halofantrine

Approved

Phase 4

69756-53-2

37393

Mecobalamin

Approved, Investigational

Phase 4

13422-55-4

Hydroxocobalamin

Approved

Phase 4

13422-51-0

15589840 44475014

Iron isomaltoside 1000

Approved, Investigational

Phase 4

1370654-58-2

Ferrous succinate

Approved

Phase 4

10030-90-7

Ferric maltol

Approved

Phase 4

33725-54-1

Ferrous fumarate

Approved

Phase 4

141-01-5

DL-alpha-Tocopherol

Approved, Experimental, Investigational, Nutraceutical, Vet_approved

Phase 4

59-02-9, 10191-41-0

2116 14985

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 4

22737-96-8, 68-26-8

5280382 445354

Glycine

Approved, Nutraceutical, Vet_approved

Phase 4

56-40-6

750

Aspartic acid

Approved, Nutraceutical

Phase 4

56-84-8

5960

Cyanocobalamin

Approved, Nutraceutical

Phase 4

68-19-9

24892734 16212801 44176380

Tocotrienol

Investigational

Phase 4

6829-55-6

9929901

Cobalamin

Experimental

Phase 4

13408-78-1

6857388

Tocotrienols

Phase 4

Tocopherols

Phase 4

Copper Supplement

Phase 4

Retinol palmitate

Phase 4

Parenteral Nutrition Solutions

Phase 4

Ferrosoferric Oxide

Phase 4

Neurotransmitter Agents

Phase 4

Caseins

Phase 4

N-Methylaspartate

Phase 4

Vitamin B12

Phase 4

Vitamin B 12

Phase 4

Chondroitin

Phase 4

9007-27-6

14389182

Iron Supplement

Phase 4

Ferric Compounds

Phase 4

Ferric gluconate

Phase 4

Hemostatics

Phase 4

Trace Elements

Phase 4

Micronutrients

Phase 4

Blood Substitutes

Phase 4

Anticoagulants

Phase 4

Plasma Substitutes

Phase 4

Epoetin Alfa

Phase 4

Orange

Approved

Phase 3

Sorbitol

Approved, Investigational

Phase 3

69-65-8, 50-70-4

453 6251 5780

Coal tar

Approved

Phase 3

8007-45-2

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 3

67-97-0, 1406-16-2

5280795 10883523

Trichostatin A

Experimental

Phase 3

58880-19-6

5562 444732

Chelating Agents

Phase 2, Phase 3

Hibiscus

Phase 3

Calciferol

Phase 3

Interventional clinical trials:

(show top 50) (show all 312)

#	Name	Status	NCT ID	Phase	Drugs
1	A Multi-Center, Randomized, Open Label Trial to Evaluate the Utility of Serum Hepcidin Levels to Predict Response to Oral or IV Iron and Compare the Safety, Effect on Quality of Life, and Resource Utilization of Injectafer vs. Intravenous Iron Standard of Care for the Treatment of Iron Deficiency Anemia (IDA) in an Infusion Center Setting	Unknown status	NCT01950247	Phase 4	Injectafer;SOC
2	the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis	Unknown status	NCT03748043	Phase 4	Lactoferrin;Ferric Hydroxide Polymaltose
3	Effectiveness of Weekly and Daily Iron Supplementation for the Prevention of Iron-deficiency Anemia in Infants. Impact on Genomic Stability	Unknown status	NCT03359447	Phase 4	Weekly Ferrous Sulfate;Daily Ferrous Sulfate
4	Does Eradication of H-pylori in Pregnant Patients With Iron Deficiency Anemia Have an Effect on Iron Replacement Therapy?	Unknown status	NCT03347513	Phase 4	triple attack therapy;Ferrous(II)-glycine-sulphate complex 567.7 mg capsules
5	Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease	Unknown status	NCT02774057	Phase 4	Captafer®;Iron Sulfate
6	Amino Acid Chelated Iron Versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia With Pregnancy: Randomized Controlled Trial	Unknown status	NCT03830034	Phase 4	Amino Acid chelated iron tab 15 mg;Ferrous Fumarate tab 350 mg( 115 mg elemental iron)
7	Randomized, Parallel Group, Clinical Trial Comparing Intravenous Iron Sucrose Versus Oral Ferrous Sulphate in the Treatment of Perioperative Iron Deficiency in Patients With Colo-Rectal Neoplasm and Iron Deficiency Anemia.	Unknown status	NCT00199277	Phase 4	i.v. iron sucrose;Oral iron
8	Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial	Unknown status	NCT03202615	Phase 4	F (ferrous sulphate)
9	The Role Of IV Iron (Ferric Carboxymaltose) And IM Vitamin B12 (Hydroxycobalamin) Supplementation In The Management Of Anaemic Prevalent Indian Hemodialysis Patients: A Parallel Group, Quadruple Blind, Placebo-Controlled, Pragmatic Randomized Control Trial With 2x2 Factorial Design	Unknown status	NCT04627181	Phase 4	Ferric carboxymaltose;Hydroxycobalamin;Placebo
10	Effektivität Der in Der Schwangerschaftsvorsorge routinemässig Angewandten Eisenprophylaxe	Unknown status	NCT02487719	Phase 4	Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
11	The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children	Unknown status	NCT01418898	Phase 4
12	The Efficacy and Safety of Vitamin C for Iron Supplementation Therapy in Adult Patients With Iron Deficiency Anemia(IDA)	Completed	NCT02631668	Phase 4	ferrous succinate and vitamin C;ferrous succinate
13	Multicenter Randomized Open-label Controlled Study to Investigate Treatment Response of IV Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia Secondary to Inflammatory Bowel Disease or Gastric Bypass	Completed	NCT02086968	Phase 4	Injectafer;Ferrous Sulfate tablets
14	A Single-center, Double-blinded, Randomized, 12 Week, Superiority Study in Infants and Young Children to Compare the Efficacy of NovaFerrum® Versus Ferrous Sulfate in the Treatment of Nutritional Iron Deficiency Anemia.	Completed	NCT01904864	Phase 4	elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
15	Lactoferrin Efficacy Versus Ferrous Sulfate in Treatment of Patients With Iron Deficiency Anemia	Completed	NCT04267653	Phase 4	Lactoferrin Bovine;Ferrous Sulfate
16	Ferrous Bis-glycinate Versus Ferrous Glycine Sulfate for the Treatment of Iron Deficiency Anemia During Pregnancy	Completed	NCT02590224	Phase 4	Ferrous bis-glycinate;Ferrous glycine sulphate
17	A Prospective, Randomized, Multi-centered Trial to Compare the Efficacy and Safety of Intravenous Iron Sucrose (Venoferrum®) With Oral Iron Acetyl-transferrin Hydroglycerin (Bolgre®) in Pregnant Women With Iron Deficiency Anemia	Completed	NCT00802139	Phase 4	venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
18	Low Dose Intravenous Versus Oral Iron for Iron Deficiency Anemia Starting Late in Pregnancy: A Randomized Controlled Trial	Completed	NCT00746551	Phase 4	Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
19	Doubling the Iron Dose VS Single Dose Iron Supplementation to Prevent Iron Deficiency Anemia (IDA) in Twin Pregnant Women: A Randomized Controlled Trial	Completed	NCT03836703	Phase 4	Feroglobin single daily use;Feroglobin twice daily dose
20	Comparison Between Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy	Completed	NCT02086838	Phase 4	Theragran Hematinic;low molecular weight iron dextran
21	The Effect of Lactoferrin Versus Iron Supplement in Treating Iron Deficiency Anemia and Helping Weight Loss in Obese School Age Children	Completed	NCT04014855	Phase 4	Iron Supplement
22	Study of KRX-0502 (Ferric Citrate) Dose Regimens in Subjects With Non-Dialysis Dependent Chronic Kidney Disease and Iron-Deficiency Anemia	Completed	NCT03236246	Phase 4	KRX-0502
23	Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia (ACCESS): A Double-Dummy Randomized Clinical Trial	Completed	NCT03524651	Phase 4	Ferrous Sulfate;Fe-ASP
24	Comparison of Lactoferrin vs Traditional Iron Therapy for Treatment of Iron Deficiency Anemia in School-age Children.	Completed	NCT04435574	Phase 4	Lactoferrin;Ferrous Sulfate
25	Phase IV Study of Oral Administration of Bovine Lactoferrin (bLf) to Prevent and Cure Iron Deficiency (ID) and Iron Deficiency Anemia (IDA) Until Delivery in Hereditary Thrombophilia (HT) Affected Pregnant Women	Completed	NCT01221844	Phase 4	FerroGrad by Abbott
26	Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial	Completed	NCT03438227	Phase 4	Iron dextran;Ferrous sulfate 325mg
27	A Randomized, Double-blind Comparative Study Comparing Ferric Carboxymaltose (Ferinject) and Iron Isomaltoside 1000 (Monofer) for Iron Substitution in Iron-deficiency Anemia	Completed	NCT02905539	Phase 4	Iron Isomaltoside 1000;Ferric Carboxymaltose
28	Endovenous Versus Liposomal Iron in CKD	Completed	NCT01864161	Phase 4	gluconate iron;Liposomal iron
29	Use of FERAHEME® (Ferumoxytol) for Severe Chronic Kidney Disease and Peritoneal Dialysis	Completed	NCT01942460	Phase 4	Ferumoxytol
30	Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure	Completed	NCT01925703	Phase 4	Sodium ferric gluconate
31	Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy: a Randomised, Comparative, Open-label Trial	Completed	NCT03188445	Phase 4	Iron Isomaltoside 1000;ferrous fumarate with ascorbic acid
32	Iron Indices and Intravenous Ferumoxytol: Time to Steady State	Completed	NCT01148745	Phase 4	ferumoxytol
33	FLIPS: Ferfer Liposomal Iron Performance Study	Completed	NCT03112187	Phase 4	Iron Supplement
34	Effect of IVIR Frequency on Anemia Correction and Oxidative Stress Formation and in Hemodialysis Patients	Completed	NCT00298441	Phase 4	chondroitin sulfate-iron colloid
35	Ferumoxytol for Anemia of CKD Trial (FACT): A Phase IV, Open-Label, Multicenter Trial, With MRI Substudy, of Repeated Doses of Ferumoxytol Compared With Iron Sucrose for Treatment of IDA in CKD Patients on Hemodialysis	Completed	NCT01227616	Phase 4	Ferumoxytol;Iron Sucrose
36	Exploratory Study of the Efficacy, Practicability and Safety of Intravenous Iron Supplementation Therapy in Moderate to Severe Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy	Completed	NCT01245777	Phase 4	ferric carboxymaltose
37	Early Antenatal Support for Iron Deficiency Anemia: A Randomized Controlled Trial of Early Initiation of Intravenous Versus Oral Iron Therapy for Treatment of Iron Deficiency Anemia in Pregnancy	Recruiting	NCT04278651	Phase 4	Ferumoxytol;Ferrous Sulfate
38	Effect of Intravenous Ferric Carboxymaltose on Hemoglobin Response and Transfusion in Patients With Iron Deficiency Anemia After Off-Pump Coronary Artery Bypass Grafting	Recruiting	NCT04898569	Phase 4	Ferinject;Normal Saline Flush
39	Alternate Day Versus Daily Oral Iron Therapy in Adolescents With Iron Deficiency Anemia and Heavy Menstrual Bleeding: A Feasibility Trial	Recruiting	NCT05007899	Phase 4	Ferrous sulfate
40	Ferric Carboxymaltose With or Without Phosphate Substitution for the Treatment of Iron Deficiency or Iron Deficiency Anemia Before Elective Surgery - the DeFICIT Trial	Recruiting	NCT05098249	Phase 4	Verum;Placebo
41	A Randomized Trial of Intermittent Oral Iron Supplementation vs. Daily Oral Iron Supplementation for the Treatment of Anemia in Pregnancy	Recruiting	NCT04594070	Phase 4	Ferrous sulfate
42	Randomized Bilnded Controlled Trial Comparing The Effect of IV Sodium Ferric Gluconate Complex (FERRLECIT R) on Outcome of Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)	Recruiting	NCT04797832	Phase 4	IV Sodium Ferric Gluconate Complex
43	The Efficacy of Intermittent Versus Daily Oral Iron Supplementation in Anaemic Pregnant Women.	Recruiting	NCT05278793	Phase 4	Ferrous fumarate
44	Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients: a Randomized Controlled Trial'	Recruiting	NCT04913649	Phase 4	Ferric Derisomaltose 100 MG/ML;Sodium chloride
45	Reducing Anemia in Pregnancy in India: the RAPIDIRON Trial	Recruiting	NCT05358509	Phase 4	Ferric carboxymaltose;Iron isomaltoside;Ferric Sulfate
46	Prospective Study of Iron Deficiency Anemia in Twin Pregnancy	Not yet recruiting	NCT04975074	Phase 4	Iron
47	Effect of Preoperative Intravenous Ferric Carboxymaltose on Postoperative Transfusion Reduction in Anemia Patients Scheduled for Clipping Surgery for Unruptured Intracranial Aneurysms	Not yet recruiting	NCT04616092	Phase 4	FEFINJECT
48	Preoperative Intravenous Iron Therapy in Patients With Gastric Cancer	Not yet recruiting	NCT04168346	Phase 4	Ferric carboxymaltose;Placebos
49	Predicting Response to Iron Supplementation in Patients With Inflammatory Bowel Disease During Induction Therapy	Not yet recruiting	NCT05456932	Phase 4	Intravenous iron;Ferric maltol;Ferrous fumarate
50	A Randomized Double-Blind Safety Comparison of Intravenous Iron Dextran Versus Iron Sucrose in an Adult Non-Hemodialysis Outpatient Population: A Pilot Study	Suspended	NCT00593619	Phase 4	Iron dextran;Iron sucrose

Search NIH Clinical Center for Iron Deficiency Anemia

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

ferric citrate

ferric oxide

ferric oxide yellow

Ferrous fumarate

ferrous gluconate

ferrous sulfate

FERROUS SULFATE GRANULES

FERROUS SULFATE,DRIED

Iron

Iron Carbonyl

iron sucrose

IRON SUMALATE

IRON,PEPTONIZED

Iron-Dextran Complex

Polysaccharide iron complex

Sodium ferric gluconate complex

Sources

Genetic Tests for Iron Deficiency Anemia

Genetic tests related to Iron Deficiency Anemia:

#	Genetic test	Affiliating Genes
1	Iron Deficiency Anemia ²⁸

Sources

Anatomical Context for Iron Deficiency Anemia

Organs/tissues related to Iron Deficiency Anemia:

MalaCards : Kidney, Liver, Heart, Colon, Bone Marrow, Small Intestine, Brain

Sources

Publications for Iron Deficiency Anemia

Articles related to Iron Deficiency Anemia:

(show top 50) (show all 8298)

#	Title	Authors	PMID	Year
1	Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. ⁵³ ⁶²	Paesano R...Valenti P	20407805	2010
2	Iron-refractory iron deficiency anemia: new molecular mechanisms. ⁵³ ⁶²	Cui Y...Zhou Y	19776721	2009
3	[Soluble tranferrin receptor in the biological diagnosis of iron deficiency. Report of 24 cases]. ⁵³ ⁶²	Zorgati MM...Ben Ammar S	20209848	2009
4	Food insecurity is associated with iron deficiency anemia in US adolescents. ⁵³ ⁶²	Eicher-Miller HA...Boushey CJ	19776137	2009
5	Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms. ⁵³ ⁶²	Ramsay AJ...Lopez-Otin C	19592582	2009
6	Concomitant severe normocytic and normochromic anemia in poststreptococcal acute glomerulonephritis. ⁵³ ⁶²	Asano T...Fujino O	19915313	2009
7	Is soluble transferrin receptor a good marker of iron deficiency anemia in chronic kidney disease patients? ⁵³ ⁶²	Gupta S...Pawar B	20436728	2009
8	Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia. ⁵³ ⁶²	Silvestri L...Grandchamp B	19357398	2009
9	[Density-specific distribution of erythrocytes in different types of anemia]. ⁵³ ⁶²	Shurkhina ES...Ataullakhanov FI	19253711	2009
10	Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study. ⁵³ ⁶²	Nappi C...Di Carlo C	19639462	2009
11	Characterization and differentiation of iron status in anemic very low birth weight infants using a diagnostic nomogram. ⁵³ ⁶²	Kasper DC...Herkner KR	18776731	2009
12	Nutritional consequences of adjustable gastric banding and gastric bypass: a 1-year prospective study. ⁵³ ⁶²	Coupaye M...Ledoux S	18542847	2009
13	Unexplained decline in the prevalence of anemia among US children and women between 1988-1994 and 1999-2002. ⁵³ ⁶²	Cusick SE...Cogswell ME	19064522	2008
14	Safety issues with intravenous iron products in the management of anemia in chronic kidney disease. ⁵³ ⁶²	Hayat A	19325171	2008
15	A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. ⁵³ ⁶²	Melis MA...Galanello R	18603562	2008
16	Weekly training volume and hematological status in female top-level athletes of different sports. ⁵³ ⁶²	Ostojic SM...Ahmetovic Z	18974729	2008
17	Serum pro-hepcidin as an indicator of iron status in dialysis patients. ⁵³ ⁶²	Tsuchihashi D...Fukagawa M	18503700	2008
18	Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease. ⁵³ ⁶²	Gisbert JP...Gomollon F	18477354	2008
19	Iron deficiency in young Lebanese children: association with elevated blood lead levels. ⁵³ ⁶²	Muwakkit S...Abboud MR	18458574	2008
20	Preventive effect of lactoferrin intake on anemia in female long distance runners. ⁵³ ⁶²	Koikawa N...Sawaki K	18391460	2008
21	Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. ⁵³ ⁶²	Usmanov RI...Shaked M	18446719	2008
22	Iron fortification: its efficacy and safety in relation to infections. ⁵³ ⁶²	Hurrell RF	18297896	2007
23	Features of iron deficiency anemia without increment in soluble transferrin receptor concentration. ⁵³ ⁶²	Choi JW	17315212	2007
24	[The expression of TfR1 mRNA and IRP1 mRNA in the placenta from different maternal iron status]. ⁵³ ⁶²	Liu CY...Xu H	17877204	2007
25	[The comparison of diagnostic usefulness of transferrin determination by immunological and chemical method in iron deficiency anemia]. ⁵³ ⁶²	Krawiec A...Szmitkowski M	17682669	2007
26	Prevalence of iron deficiency and anemia among healthy women of reproductive age in Bhaktapur, Nepal. ⁵³ ⁶²	Chandyo RK...Sommerfelt H	16929243	2007
27	Nonhematological benefits of iron. ⁵³ ⁶²	Agarwal R	17804903	2007
28	Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice. ⁵³ ⁶²	Lyoumi S...Puy H	17003376	2007
29	[Study on serum erythropoietin levels in patients with hematologic malignancies]. ⁵³ ⁶²	Han B...Shen T	17172129	2006
30	The interaction between heart failure and other heart diseases, renal failure, and anemia. ⁵³ ⁶²	Silverberg DS...Schwartz D	16949468	2006
31	Adjusting i.v. iron and EPO doses in patients on hemodialysis prior to continuing surgery: can we protect our patients education from iron-deficiency anemia? ⁵³ ⁶²	Deaver K...Bennington L	17002001	2006
32	Gastric antral vascular ectasia (watermelon stomach) in patients with ESRD. ⁵³ ⁶²	Stefanidis I...Potamianos SP	16731286	2006
33	Iron indices: what do they really mean? ⁵³ ⁶²	Coyne D	16830699	2006
34	Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency. ⁵³ ⁶²	Recalcati S...Cairo G	16503547	2006
35	Carbohydrate-deficient isoforms of transferrin (%CDT) and sialic acid (SA) in iron-deficiency anemia. ⁵³ ⁶²	Cylwik B...Koput A	16178908	2005
36	Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia. ⁵³ ⁶²	Choi JW...Son BK	15820481	2005
37	Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children. ⁵³ ⁶²	Zimmermann MB...Hurrell RF	15755831	2005
38	Comparison of the serum erythropoietin levels in chemotherapy-naive and cisplatin-treated cancer patients. ⁵³ ⁶²	Arslan M...Manavoglu O	15739025	2005
39	Iron status of the Taiwanese elderly: the prevalence of iron deficiency and elevated iron stores. ⁵³ ⁶²	Wang JL...Shaw NS	16169840	2005
40	Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis. ⁵³ ⁶²	Margetic S...Kvaternik M	15843240	2005
41	The soluble transferrin receptor (sTfR)-ferritin index is a potential predictor of celiac disease in children with refractory iron deficiency anemia. ⁵³ ⁶²	De Caterina M...Scopacasa F	15653440	2005
42	Serum transferrin receptor levels in beta-thalassemia trait. ⁵³ ⁶²	Demir A...Kara A	15537726	2004
43	Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method. ⁵³ ⁶²	Tondeur MC...Zlotkin SH	15531698	2004
44	Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. ⁵³ ⁶²	Bethell DR...Huang J	15222487	2004
45	Factors associated with iron deficiency anemia in Brazilian preschool children. ⁵³ ⁶²	Almeida CA...Oliveira JE	15192767	2004
46	Prevalence of iron depletion and anemia in top-level basketball players. ⁵³ ⁶²	Dubnov G...Constantini NW	15129928	2004
47	[Conventional and new laboratory parameters in the evaluation of hematologic disease]. ⁵³ ⁶²	Herklotz R...Huber AR	15018392	2004
48	EPO and TPO sequences do not explain thrombocytosis in iron deficiency anemia. ⁵³ ⁶²	Racke FK	14608206	2003
49	Contribution of iron deficiency to anemia in chronic renal failure. ⁵³ ⁶²	Gupta M...Saxena R	15025343	2003
50	Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. ⁵³ ⁶²	Thuy PV...Khoi HH	12885710	2003

Sources

Genes for Iron Deficiency Anemia

Genes related to Iron Deficiency Anemia (0 elite genes):

(show all 30)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TMPRSS6	Transmembrane Serine Protease 6	Protein Coding	36.43	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	19357398 19592582 18603562
2	TFRC	Transferrin Receptor	Protein Coding	26.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7513628 12870058 15843240 (more) 10508130 20209848 11190796 10977038 12605386 15018392 1890732 12885710 17003376 16929243 15531698 17315212 15653440 15104997 12774668 8327847 17877204 18297896 15755831 12910643 12619948 12547240 10376576 15537726 9028338 12218295 1583389 20436728 15192767 15820481
3	EPO	Erythropoietin	Protein Coding	25.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11262469 10713657 1460322 (more) 15739025 1288287 11306899 8350498 1552389 8355412 16731286 8054570 17804903 9433147 16949468 17172129 10401012 8510335 1421381 19776721 17002001 12902931 10940653 18446719 18477354 11225250 8352231 8345655 1923199 2213753 18776731 15025343 18503700 7693989 1588794 11799582 7658327 8350509 2342534 1433935 1765284 1936885 19915313 7557862 14608206 8575124 19325171 16830699 9462542 9544165
4	SLC11A2	Solute Carrier Family 11 Member 2	Protein Coding	23.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12547214 11897618
5	TF	Transferrin	Protein Coding	23.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17682669 20209848 9492551 (more) 1486679 16178908 11237943 19064522 8278699 10772870 11190796 10469862 15018392 18458574 15129928 16169840 8122498 18974729 8561058 10367478 11431174 12547238 19776137 11010938 10376576 1305791 10442492 1874482 2178409 18542847
6	HFE	Homeostatic Iron Regulator	Protein Coding	20.81	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10979877 12547214 10772870
7	HAMP	Hepcidin Antimicrobial Peptide	Protein Coding	17.61	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	THPO	Thrombopoietin	Protein Coding	17.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14608206 12902931 9626028
9	HJV	Hemojuvelin BMP Co-Receptor	Protein Coding	15.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	LTF	Lactotransferrin	Protein Coding	15.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12859729 19639462 18391460 (more) 15222487 20407805
11	TFR2	Transferrin Receptor 2	Protein Coding	14.96	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	14.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10926279 19253711 1808415 (more) 10865417
13	CRP	C-Reactive Protein	Protein Coding	14.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	HEPH	Hephaestin	Protein Coding	14.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11897618
15	IL6	Interleukin 6	Protein Coding	13.78	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	SLC40A1	Solute Carrier Family 40 Member 1	Protein Coding	13.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11897618
17	TNF	Tumor Necrosis Factor	Protein Coding	13.43	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	CP	Ceruloplasmin	Protein Coding	12.85	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	FTL	Ferritin Light Chain	Protein Coding	12.85	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	HBG2	Hemoglobin Subunit Gamma 2	Protein Coding	12.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11692726
21	IL11	Interleukin 11	Protein Coding	11.19	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	ACO1	Aconitase 1	Protein Coding	11.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16503547 17877204
23	IREB2	Iron Responsive Element Binding Protein 2	Protein Coding	10.79	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16503547
24	GSR	Glutathione-Disulfide Reductase	Protein Coding	10.49	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	FECH	Ferrochelatase	Protein Coding	10.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11214507
26	CAT	Catalase	Protein Coding	7.63	GeneCards inferred via : Publications (show sections)
27	CYBRD1	Cytochrome B Reductase 1	Protein Coding	7.46	DISEASES inferred ¹⁴
28	CYGB	Cytoglobin	Protein Coding	7.43	DISEASES inferred ¹⁴
29	ERFE	Erythroferrone	Protein Coding	7.4	DISEASES inferred ¹⁴
30	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	7.28	DISEASES inferred ¹⁴

Sources

Variations for Iron Deficiency Anemia

ClinVar genetic disease variations for Iron Deficiency Anemia:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	TF	NM_001063.4(TF):c.829G>A (p.Gly277Ser)	SNV	Uncertain Significance	12622	rs1799899	GRCh37: 3:133475812-133475812 GRCh38: 3:133756968-133756968

Sources

Expression for Iron Deficiency Anemia

Search GEO for disease gene expression data for Iron Deficiency Anemia.

Sources

Pathways for Iron Deficiency Anemia

Pathways related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Transport of inorganic cations/anions and amino acids/oligopeptides ⁶⁶ Show member pathways Amino acid transport across the plasma membrane ⁶⁶ Bicarbonate transporters ⁶⁶ Cation-coupled Chloride cotransporters ⁶⁶ Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) ⁶⁶ Defective SLC12A1 causes Bartter syndrome 1 (BS1) ⁶⁶ Defective SLC12A3 causes Gitelman syndrome (GS) ⁶⁶ Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) ⁶⁶ Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) ⁶⁶ Defective SLC17A5 causes Salla disease (SD) and ISSD ⁶⁶ Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) ⁶⁶ Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) ⁶⁶ Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) ⁶⁶ Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) ⁶⁶ Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) ⁶⁶ Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) ⁶⁶ Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) ⁶⁶ Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) ⁶⁶ Defective SLC26A4 causes Pendred syndrome (PDS) ⁶⁶ Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) ⁶⁶ Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ⁶⁶ Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) ⁶⁶ Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) ⁶⁶ Defective SLC6A5 causes hyperekplexia 3 (HKPX3) ⁶⁶ Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) ⁶⁶ Defective SLC9A9 causes autism 16 (AUTS16) ⁶⁶ Inositol transporters ⁶⁶ Multifunctional anion exchangers ⁶⁶ Na+/Cl- dependent neurotransmitter transporters ⁶⁶ Organic anion transport ⁶⁶ Organic anion transporters ⁶⁶ Organic cation transport ⁶⁶ Organic cation/anion/zwitterion transport ⁶⁶ Proton/oligopeptide cotransporters ⁶⁶ Proton-coupled monocarboxylate transport ⁶⁶ Proton-coupled neutral amino acid transporters ⁶⁶ Rhesus glycoproteins mediate ammonium transport. ⁶⁶ SLC-mediated transmembrane transport ⁶⁶ Sodium/Calcium exchangers ⁶⁶ Sodium/Proton exchangers ⁶⁶ Sodium-coupled phosphate cotransporters ⁶⁶ Sodium-coupled sulphate, di- and tri-carboxylate transporters ⁶⁶ Transport of bile salts and organic acids, metal ions and amine compounds ⁶⁶ Transport of small molecules ⁶⁶ Type II Na+/Pi cotransporters ⁶⁶ Variant SLC6A14 may confer susceptibility towards obesity ⁶⁶	13.16	CP FTL HEPH HFE SLC11A2 SLC40A1
2	Disorders of transmembrane transporters ⁶⁶ Show member pathways SLC transporter disorders ⁶⁶	12.3	SLC40A1 SLC11A2 HEPH CP
3	Metal ion SLC transporters ⁶⁶ Show member pathways Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) ⁶⁶ Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) ⁶⁶ Metallothioneins bind metals ⁶⁶ MTF1 activates gene expression ⁶⁶ Response to metal ions ⁶⁶ Zinc efflux and compartmentalization by the SLC30 family ⁶⁶ Zinc homeostasis ⁷⁴ Zinc influx into cells by the SLC39 gene family ⁶⁶ Zinc transporters ⁶⁶	11.86	SLC40A1 SLC11A2 HEPH CP
4	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.82	TNF THPO IL6 EPO
5	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.56	TNF IL6 CRP
6	HIF-1-alpha transcription factor network ⁶¹	11.52	TFRC TF EPO CP
7	Insulin receptor recycling ⁶⁶ Show member pathways ATP biosynthesis ⁶¹ Events associated with phagocytolytic activity of PMN cells ⁶⁶ Iron uptake and transport ⁶⁶ melatonin degradation III ⁶¹ ROS and RNS production in phagocytes ⁶⁶ Transferrin endocytosis and recycling ⁶⁶	11.51	TFRC TFR2 TF SLC40A1 SLC11A2 HFE
8	3q29 copy number variation syndrome ⁷⁴	11.45	TFRC TF SLC40A1 HFE HAMP
9	Pluripotent stem cell differentiation pathway ⁷⁴	11.37	TF IL6 EPO
10	Ferroptosis ⁷⁴	11.24	TFRC TF SLC40A1 SLC11A2 FTL CP
11	Overview of nanoparticle effects ⁷⁴	10.89	TNF IL6 CRP
12	Nanoparticle triggered regulated necrosis ⁷⁴	10.63	TNF FTL
13	Iron metabolism in placenta ⁷⁴	10.4	TFR2 SLC40A1 SLC11A2
14	Hfe effect on hepcidin production ⁷⁴	10.3	TMPRSS6 HJV HFE HAMP
15	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.22	TNF IL6
16	Defective CP causes aceruloplasminemia (ACERULOP) ⁶⁶ Show member pathways Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) ⁶⁶	10.1	SLC40A1 CP

Sources

GO Terms for Iron Deficiency Anemia

Cellular components related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.45	TNF THPO TFRC TF LTF IL6
2	extracellular space	GO:0005615	10.27	CP CRP EPO HAMP HFE HJV
3	cell surface	GO:0009986	10.17	TNF TFRC TF SLC11A2 LTF HJV
4	blood microparticle	GO:0072562	9.97	CP HBG2 TF TFRC
5	basal part of cell	GO:0045178	9.73	HFE SLC11A2 TF
6	recycling endosome	GO:0055037	9.73	TNF TFRC TF SLC11A2 LTF HFE
7	HFE-transferrin receptor complex	GO:1990712	9.32	TFRC TFR2 TF HJV HFE

Biological processes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular iron ion homeostasis	GO:0006879	10.23	CP FTL HAMP HEPH HFE HJV
2	acute-phase response	GO:0006953	10.03	CRP EPO HAMP IL6 TFR2 TFRC
3	osteoclast differentiation	GO:0030316	10.02	TNF TFRC TF
4	monoatomic ion transport	GO:0006811	10.02	TF SLC40A1 SLC11A2 LTF HFE HEPH
5	response to iron ion	GO:0010039	10.02	TFRC TFR2 SLC11A2 HFE HAMP
6	liver regeneration	GO:0097421	10.01	TNF IL6 HAMP
7	iron ion homeostasis	GO:0055072	10	CP FTL HAMP HEPH HFE HJV
8	copper ion transport	GO:0006825	9.97	SLC11A2 HEPH CP
9	multicellular organismal iron ion homeostasis	GO:0060586	9.97	SLC40A1 SLC11A2 HFE HAMP
10	iron ion transmembrane transport	GO:0034755	9.93	HAMP SLC11A2 SLC40A1
11	negative regulation of lipid storage	GO:0010888	9.91	TNF IL6 CRP
12	cellular response to iron ion	GO:0071281	9.88	TFR2 TF HFE
13	response to iron ion starvation	GO:1990641	9.83	HFE HAMP
14	regulation of iron ion transport	GO:0034756	9.81	TF HFE
15	iron ion transport	GO:0006826	9.55	CP FTL HEPH LTF SLC11A2 SLC40A1

Molecular functions related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ferrous iron binding	GO:0008198	9.63	TF HEPH FTL
2	ferrous iron transmembrane transporter activity	GO:0015093	9.62	SLC40A1 SLC11A2
3	ferroxidase activity	GO:0004322	9.56	HEPH CP
4	transferrin receptor activity	GO:0004998	9.26	TFRC TFR2
5	transferrin receptor binding	GO:1990459	9.1	TF HJV HFE