MCID: IRN001
MIFTS: 59

Iron Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases
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Aliases & Classifications for Iron Deficiency Anemia

MalaCards integrated aliases for Iron Deficiency Anemia:

Name: Iron Deficiency Anemia 11 28 53 5 14 71
Iron-Deficiency Anemia 63 75
Fe - [iron] Deficiency Anemia Nos 33
Ida - [iron Deficiency Anemia] 33
Fe Deficiency Anaemia 33

Classifications:



External Ids:

Disease Ontology 11 DOID:11758
ICD9CM 34 280.8
SNOMED-CT 68 191129007
ICD10 31 D50 D50.9
UMLS 71 C0029810 C0162316

Summaries for Iron Deficiency Anemia

PubMed Health : 63 Iron-deficiency anemia: Iron-deficiency anemia is a common, easily treated condition that occurs if you don't have enough iron in your body. Low iron levels usually are due to blood loss, poor diet, or an inability to absorb enough iron from food.

MalaCards based summary: Iron Deficiency Anemia, also known as iron-deficiency anemia, is related to iron-refractory iron deficiency anemia and celiac disease 1. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Disorders of transmembrane transporters. The drugs Tocopherol and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart, and related phenotypes are homeostasis/metabolism and liver/biliary system

Disease Ontology: 11 A nutritional deficiency disease that is characterized by pallor, fatigue, lightheadedness, and weakness and has material basis in low total body iron causing impaired synthesis of red blood cells.

Wikipedia: 75 Iron-deficiency anemia is anemia caused by a lack of iron. Anemia is defined as a decrease in the number... more...

Related Diseases for Iron Deficiency Anemia

Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 33.7 TMPRSS6 HJV
2 celiac disease 1 31.6 TNF TFRC IL6 HFE CRP
3 thrombocytosis 31.5 THPO IL6 EPO CRP
4 bowel dysfunction 31.5 TNF LTF IL6 CRP
5 thalassemia minor 31.4 HBG2 HAMP EPO
6 iron metabolism disease 31.4 TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2
7 microcytic anemia 31.3 TMPRSS6 TFRC TFR2 TF SLC40A1 SLC11A2
8 chronic kidney disease 31.2 TNF TF IL6 EPO CRP
9 vitamin b12 deficiency 31.2 HAMP EPO CRP
10 peptic ulcer disease 31.1 TNF IL6 CRP
11 hemorrhoid 31.1 TNF IL6 CRP
12 restless legs syndrome 31.1 TFRC SLC11A2 HAMP FTL EPO
13 sickle cell disease 30.9 HBG2 G6PD EPO
14 nutritional deficiency disease 30.9 TMPRSS6 TFRC TF SLC11A2 IL6 HJV
15 thrombocytopenia 30.9 TNF THPO TFRC IL6 EPO CRP
16 kidney disease 30.9 TNF TF IL6 HFE HAMP EPO
17 crohn's disease 30.8 TNF LTF IL6 CRP
18 polycythemia 30.8 THPO TFRC HAMP EPO CRP
19 thalassemia 30.8 TMPRSS6 TFRC TFR2 TF SLC40A1 HJV
20 intracranial hypertension 30.8 TNF IL6 CRP
21 purpura 30.7 TNF THPO IL6 CRP
22 gastroenteritis 30.7 TNF IL6 CRP CP
23 anemia, sideroblastic, 1 30.7 TMPRSS6 TFRC TFR2 SLC40A1 SLC11A2 HJV
24 iron overload 30.7 TFR2 TF SLC40A1 SLC11A2 HJV HFE
25 asphyxia neonatorum 30.7 IL6 EPO CRP
26 urinary tract infection 30.7 TNF IL6 CRP
27 aplastic anemia 30.6 TNF THPO TFRC IL6 EPO
28 folic acid deficiency anemia 30.6 HAMP EPO CRP
29 lactose intolerance 30.6 TNF IL6 CRP
30 pouchitis 30.6 TNF LTF
31 hypochromic microcytic anemia 30.6 TMPRSS6 TFRC TF SLC40A1 SLC11A2 HJV
32 adult syndrome 30.6 TNF IL6 CRP
33 alpha-thalassemia 30.6 TNF TMPRSS6 TFRC HFE HBG2 HAMP
34 vasculitis 30.6 TNF LTF IL6 CRP
35 intestinal obstruction 30.6 TNF IL6 CRP
36 common cold 30.6 TNF IL6 CRP
37 chronic fatigue syndrome 30.6 TNF IL6 CRP
38 liver cirrhosis 30.5 TNF THPO TF IL6 HFE
39 exanthem 30.5 TNF IL6 CRP
40 hemoglobinuria 30.5 THPO G6PD EPO
41 sickle cell anemia 30.5 TNF TFRC IL6 HBG2 HAMP G6PD
42 deficiency anemia 30.5 TNF TMPRSS6 THPO TFRC TFR2 TF
43 alcohol use disorder 30.5 TNF TF IL6 HFE CRP
44 thyroiditis 30.5 TNF IL6 CRP
45 fibromyalgia 30.5 TNF IL6 CRP
46 anemia of prematurity 30.5 TFRC HAMP EPO
47 pulmonary tuberculosis 30.5 TNF IL6 CRP CP
48 sleep disorder 30.4 TNF IL6 CRP
49 hemolytic anemia 30.4 TMPRSS6 TFRC TF HFE HBG2 HAMP
50 substance abuse 30.4 TNF TF IL6 CRP

Comorbidity relations with Iron Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 97)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Alcoholic Liver Cirrhosis Alzheimer Disease, Familial, 1
Anxiety Aortic Valve Disease 1
Ascending Colon Cancer Atrophic Gastritis
Benign Essential Hypertension Bronchitis
Bronchopneumonia Cecal Benign Neoplasm
Celiac Disease 1 Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Intestinal Vascular Insufficiency Chronic Kidney Disease
Chylomicron Retention Disease Colorectal Cancer
Conjunctivitis Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Duodenitis
Dysthymic Disorder Encephalopathy
Esophageal Candidiasis Esophageal Disease
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Folic Acid Deficiency Anemia
Gastric Cancer Gastrointestinal System Cancer
Generalized Atherosclerosis Gout
Heart Disease Hepatic Flexure Cancer
Hydronephrosis Hypersplenism
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma
Hypothyroidism Inflammatory Bowel Disease 1

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to Iron Deficiency Anemia

Symptoms & Phenotypes for Iron Deficiency Anemia

GenomeRNAi Phenotypes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.11 CP CRP EPO FTL G6PD HAMP
2 no effect GR00402-S-2 10.11 CP CRP EPO FTL HBG2 HEPH

MGI Mouse Phenotypes related to Iron Deficiency Anemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 CP CRP EPO FTL G6PD HAMP
2 liver/biliary system MP:0005370 10.33 CP EPO FTL HAMP HEPH HFE
3 nervous system MP:0003631 10.29 CP FTL G6PD HEPH HFE HJV
4 growth/size/body region MP:0005378 10.22 CP FTL G6PD HAMP HFE IL6
5 immune system MP:0005387 10.21 CP CRP EPO FTL G6PD HAMP
6 cardiovascular system MP:0005385 10.2 CP CRP EPO FTL G6PD HEPH
7 hematopoietic system MP:0005397 10.11 CP EPO FTL G6PD HAMP HEPH
8 digestive/alimentary MP:0005381 9.97 HEPH HFE IL6 SLC40A1 TFR2 TFRC
9 mortality/aging MP:0010768 9.8 EPO FTL G6PD HAMP HFE HJV
10 integument MP:0010771 9.28 HEPH HJV IL6 SLC11A2 SLC40A1 TF

Drugs & Therapeutics for Iron Deficiency Anemia

PubMed Health treatment related to Iron Deficiency Anemia: 63

Treatment for iron -deficiency anemia will depend on its cause and severity. Treatments may include dietary changes and supplements, medicines, and surgery . Severe iron -deficiency anemia may require a blood transfusion , iron injections , or intravenous (IV) iron therapy . Treatment may need to be done in a hospital. The goals of treating iron -deficiency anemia are to treat its underlying cause and restore normal levels of red blood cells , hemoglobin , and iron.

Drugs for Iron Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2
2
Esomeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6, 119141-88-7 9568614 4594
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4
Metronidazole Approved Phase 4 443-48-1, 69198-10-3 4173
5
Zinc cation Approved, Experimental, Investigational Phase 4 7440-66-6, 23713-49-7 32051
6
Copper Approved, Investigational Phase 4 7440-50-8 27099
7
Halofantrine Approved Phase 4 69756-53-2 37393
8
Mecobalamin Approved, Investigational Phase 4 13422-55-4
9
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 44475014
10
Iron isomaltoside 1000 Approved, Investigational Phase 4 1370654-58-2
11
Ferrous succinate Approved Phase 4 10030-90-7
12
Ferric maltol Approved Phase 4 33725-54-1
13
Ferrous fumarate Approved Phase 4 141-01-5
14
DL-alpha-Tocopherol Approved, Experimental, Investigational, Nutraceutical, Vet_approved Phase 4 59-02-9, 10191-41-0 2116 14985
15
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8 5280382 445354
16
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
17
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
18
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 24892734 16212801 44176380
19
Tocotrienol Investigational Phase 4 6829-55-6 9929901
20
Cobalamin Experimental Phase 4 13408-78-1 6857388
21 Tocotrienols Phase 4
22 Tocopherols Phase 4
23 Copper Supplement Phase 4
24 Retinol palmitate Phase 4
25 Parenteral Nutrition Solutions Phase 4
26 Ferrosoferric Oxide Phase 4
27 Neurotransmitter Agents Phase 4
28 Caseins Phase 4
29 N-Methylaspartate Phase 4
30 Vitamin B12 Phase 4
31 Vitamin B 12 Phase 4
32
Chondroitin Phase 4 9007-27-6 14389182
33 Iron Supplement Phase 4
34 Ferric Compounds Phase 4
35 Ferric gluconate Phase 4
36 Hemostatics Phase 4
37 Trace Elements Phase 4
38 Micronutrients Phase 4
39 Blood Substitutes Phase 4
40 Anticoagulants Phase 4
41 Plasma Substitutes Phase 4
42
Epoetin Alfa Phase 4
43 Orange Approved Phase 3
44
Sorbitol Approved, Investigational Phase 3 69-65-8, 50-70-4 453 6251 5780
45
Coal tar Approved Phase 3 8007-45-2
46
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 3 67-97-0, 1406-16-2 5280795 10883523
47
Trichostatin A Experimental Phase 3 58880-19-6 5562 444732
48 Chelating Agents Phase 2, Phase 3
49 Hibiscus Phase 3
50 Calciferol Phase 3

Interventional clinical trials:

(show top 50) (show all 312)
# Name Status NCT ID Phase Drugs
1 A Multi-Center, Randomized, Open Label Trial to Evaluate the Utility of Serum Hepcidin Levels to Predict Response to Oral or IV Iron and Compare the Safety, Effect on Quality of Life, and Resource Utilization of Injectafer vs. Intravenous Iron Standard of Care for the Treatment of Iron Deficiency Anemia (IDA) in an Infusion Center Setting Unknown status NCT01950247 Phase 4 Injectafer;SOC
2 the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis Unknown status NCT03748043 Phase 4 Lactoferrin;Ferric Hydroxide Polymaltose
3 Effectiveness of Weekly and Daily Iron Supplementation for the Prevention of Iron-deficiency Anemia in Infants. Impact on Genomic Stability Unknown status NCT03359447 Phase 4 Weekly Ferrous Sulfate;Daily Ferrous Sulfate
4 Does Eradication of H-pylori in Pregnant Patients With Iron Deficiency Anemia Have an Effect on Iron Replacement Therapy? Unknown status NCT03347513 Phase 4 triple attack therapy;Ferrous(II)-glycine-sulphate complex 567.7 mg capsules
5 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
6 Amino Acid Chelated Iron Versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia With Pregnancy: Randomized Controlled Trial Unknown status NCT03830034 Phase 4 Amino Acid chelated iron tab 15 mg;Ferrous Fumarate tab 350 mg( 115 mg elemental iron)
7 Randomized, Parallel Group, Clinical Trial Comparing Intravenous Iron Sucrose Versus Oral Ferrous Sulphate in the Treatment of Perioperative Iron Deficiency in Patients With Colo-Rectal Neoplasm and Iron Deficiency Anemia. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
8 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial Unknown status NCT03202615 Phase 4 F (ferrous sulphate)
9 The Role Of IV Iron (Ferric Carboxymaltose) And IM Vitamin B12 (Hydroxycobalamin) Supplementation In The Management Of Anaemic Prevalent Indian Hemodialysis Patients: A Parallel Group, Quadruple Blind, Placebo-Controlled, Pragmatic Randomized Control Trial With 2x2 Factorial Design Unknown status NCT04627181 Phase 4 Ferric carboxymaltose;Hydroxycobalamin;Placebo
10 Effektivität Der in Der Schwangerschaftsvorsorge routinemässig Angewandten Eisenprophylaxe Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
11 The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children Unknown status NCT01418898 Phase 4
12 The Efficacy and Safety of Vitamin C for Iron Supplementation Therapy in Adult Patients With Iron Deficiency Anemia(IDA) Completed NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate
13 Multicenter Randomized Open-label Controlled Study to Investigate Treatment Response of IV Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia Secondary to Inflammatory Bowel Disease or Gastric Bypass Completed NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
14 A Single-center, Double-blinded, Randomized, 12 Week, Superiority Study in Infants and Young Children to Compare the Efficacy of NovaFerrum® Versus Ferrous Sulfate in the Treatment of Nutritional Iron Deficiency Anemia. Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
15 Lactoferrin Efficacy Versus Ferrous Sulfate in Treatment of Patients With Iron Deficiency Anemia Completed NCT04267653 Phase 4 Lactoferrin Bovine;Ferrous Sulfate
16 Ferrous Bis-glycinate Versus Ferrous Glycine Sulfate for the Treatment of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
17 A Prospective, Randomized, Multi-centered Trial to Compare the Efficacy and Safety of Intravenous Iron Sucrose (Venoferrum®) With Oral Iron Acetyl-transferrin Hydroglycerin (Bolgre®) in Pregnant Women With Iron Deficiency Anemia Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
18 Low Dose Intravenous Versus Oral Iron for Iron Deficiency Anemia Starting Late in Pregnancy: A Randomized Controlled Trial Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
19 Doubling the Iron Dose VS Single Dose Iron Supplementation to Prevent Iron Deficiency Anemia (IDA) in Twin Pregnant Women: A Randomized Controlled Trial Completed NCT03836703 Phase 4 Feroglobin single daily use;Feroglobin twice daily dose
20 Comparison Between Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
21 The Effect of Lactoferrin Versus Iron Supplement in Treating Iron Deficiency Anemia and Helping Weight Loss in Obese School Age Children Completed NCT04014855 Phase 4 Iron Supplement
22 Study of KRX-0502 (Ferric Citrate) Dose Regimens in Subjects With Non-Dialysis Dependent Chronic Kidney Disease and Iron-Deficiency Anemia Completed NCT03236246 Phase 4 KRX-0502
23 Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia (ACCESS): A Double-Dummy Randomized Clinical Trial Completed NCT03524651 Phase 4 Ferrous Sulfate;Fe-ASP
24 Comparison of Lactoferrin vs Traditional Iron Therapy for Treatment of Iron Deficiency Anemia in School-age Children. Completed NCT04435574 Phase 4 Lactoferrin;Ferrous Sulfate
25 Phase IV Study of Oral Administration of Bovine Lactoferrin (bLf) to Prevent and Cure Iron Deficiency (ID) and Iron Deficiency Anemia (IDA) Until Delivery in Hereditary Thrombophilia (HT) Affected Pregnant Women Completed NCT01221844 Phase 4 FerroGrad by Abbott
26 Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial Completed NCT03438227 Phase 4 Iron dextran;Ferrous sulfate 325mg
27 A Randomized, Double-blind Comparative Study Comparing Ferric Carboxymaltose (Ferinject) and Iron Isomaltoside 1000 (Monofer) for Iron Substitution in Iron-deficiency Anemia Completed NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose
28 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
29 Use of FERAHEME® (Ferumoxytol) for Severe Chronic Kidney Disease and Peritoneal Dialysis Completed NCT01942460 Phase 4 Ferumoxytol
30 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
31 Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy: a Randomised, Comparative, Open-label Trial Completed NCT03188445 Phase 4 Iron Isomaltoside 1000;ferrous fumarate with ascorbic acid
32 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
33 FLIPS: Ferfer Liposomal Iron Performance Study Completed NCT03112187 Phase 4 Iron Supplement
34 Effect of IVIR Frequency on Anemia Correction and Oxidative Stress Formation and in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
35 Ferumoxytol for Anemia of CKD Trial (FACT): A Phase IV, Open-Label, Multicenter Trial, With MRI Substudy, of Repeated Doses of Ferumoxytol Compared With Iron Sucrose for Treatment of IDA in CKD Patients on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
36 Exploratory Study of the Efficacy, Practicability and Safety of Intravenous Iron Supplementation Therapy in Moderate to Severe Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
37 Early Antenatal Support for Iron Deficiency Anemia: A Randomized Controlled Trial of Early Initiation of Intravenous Versus Oral Iron Therapy for Treatment of Iron Deficiency Anemia in Pregnancy Recruiting NCT04278651 Phase 4 Ferumoxytol;Ferrous Sulfate
38 Effect of Intravenous Ferric Carboxymaltose on Hemoglobin Response and Transfusion in Patients With Iron Deficiency Anemia After Off-Pump Coronary Artery Bypass Grafting Recruiting NCT04898569 Phase 4 Ferinject;Normal Saline Flush
39 Alternate Day Versus Daily Oral Iron Therapy in Adolescents With Iron Deficiency Anemia and Heavy Menstrual Bleeding: A Feasibility Trial Recruiting NCT05007899 Phase 4 Ferrous sulfate
40 Ferric Carboxymaltose With or Without Phosphate Substitution for the Treatment of Iron Deficiency or Iron Deficiency Anemia Before Elective Surgery - the DeFICIT Trial Recruiting NCT05098249 Phase 4 Verum;Placebo
41 A Randomized Trial of Intermittent Oral Iron Supplementation vs. Daily Oral Iron Supplementation for the Treatment of Anemia in Pregnancy Recruiting NCT04594070 Phase 4 Ferrous sulfate
42 Randomized Bilnded Controlled Trial Comparing The Effect of IV Sodium Ferric Gluconate Complex (FERRLECIT R) on Outcome of Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) Recruiting NCT04797832 Phase 4 IV Sodium Ferric Gluconate Complex
43 The Efficacy of Intermittent Versus Daily Oral Iron Supplementation in Anaemic Pregnant Women. Recruiting NCT05278793 Phase 4 Ferrous fumarate
44 Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients: a Randomized Controlled Trial' Recruiting NCT04913649 Phase 4 Ferric Derisomaltose 100 MG/ML;Sodium chloride
45 Reducing Anemia in Pregnancy in India: the RAPIDIRON Trial Recruiting NCT05358509 Phase 4 Ferric carboxymaltose;Iron isomaltoside;Ferric Sulfate
46 Prospective Study of Iron Deficiency Anemia in Twin Pregnancy Not yet recruiting NCT04975074 Phase 4 Iron
47 Effect of Preoperative Intravenous Ferric Carboxymaltose on Postoperative Transfusion Reduction in Anemia Patients Scheduled for Clipping Surgery for Unruptured Intracranial Aneurysms Not yet recruiting NCT04616092 Phase 4 FEFINJECT
48 Preoperative Intravenous Iron Therapy in Patients With Gastric Cancer Not yet recruiting NCT04168346 Phase 4 Ferric carboxymaltose;Placebos
49 Predicting Response to Iron Supplementation in Patients With Inflammatory Bowel Disease During Induction Therapy Not yet recruiting NCT05456932 Phase 4 Intravenous iron;Ferric maltol;Ferrous fumarate
50 A Randomized Double-Blind Safety Comparison of Intravenous Iron Dextran Versus Iron Sucrose in an Adult Non-Hemodialysis Outpatient Population: A Pilot Study Suspended NCT00593619 Phase 4 Iron dextran;Iron sucrose

Search NIH Clinical Center for Iron Deficiency Anemia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ferric citrate
ferric oxide
ferric oxide yellow
Ferrous fumarate
ferrous gluconate
ferrous sulfate
FERROUS SULFATE GRANULES
FERROUS SULFATE,DRIED
Iron
Iron Carbonyl
iron sucrose
IRON SUMALATE
IRON,PEPTONIZED
Iron-Dextran Complex
Polysaccharide iron complex
Sodium ferric gluconate complex

Genetic Tests for Iron Deficiency Anemia

Genetic tests related to Iron Deficiency Anemia:

# Genetic test Affiliating Genes
1 Iron Deficiency Anemia 28

Anatomical Context for Iron Deficiency Anemia

Organs/tissues related to Iron Deficiency Anemia:

MalaCards : Kidney, Liver, Heart, Colon, Bone Marrow, Small Intestine, Brain

Publications for Iron Deficiency Anemia

Articles related to Iron Deficiency Anemia:

(show top 50) (show all 8298)
# Title Authors PMID Year
1
Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women. 53 62
20407805 2010
2
Iron-refractory iron deficiency anemia: new molecular mechanisms. 53 62
19776721 2009
3
[Soluble tranferrin receptor in the biological diagnosis of iron deficiency. Report of 24 cases]. 53 62
20209848 2009
4
Food insecurity is associated with iron deficiency anemia in US adolescents. 53 62
19776137 2009
5
Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms. 53 62
19592582 2009
6
Concomitant severe normocytic and normochromic anemia in poststreptococcal acute glomerulonephritis. 53 62
19915313 2009
7
Is soluble transferrin receptor a good marker of iron deficiency anemia in chronic kidney disease patients? 53 62
20436728 2009
8
Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia. 53 62
19357398 2009
9
[Density-specific distribution of erythrocytes in different types of anemia]. 53 62
19253711 2009
10
Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study. 53 62
19639462 2009
11
Characterization and differentiation of iron status in anemic very low birth weight infants using a diagnostic nomogram. 53 62
18776731 2009
12
Nutritional consequences of adjustable gastric banding and gastric bypass: a 1-year prospective study. 53 62
18542847 2009
13
Unexplained decline in the prevalence of anemia among US children and women between 1988-1994 and 1999-2002. 53 62
19064522 2008
14
Safety issues with intravenous iron products in the management of anemia in chronic kidney disease. 53 62
19325171 2008
15
A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. 53 62
18603562 2008
16
Weekly training volume and hematological status in female top-level athletes of different sports. 53 62
18974729 2008
17
Serum pro-hepcidin as an indicator of iron status in dialysis patients. 53 62
18503700 2008
18
Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease. 53 62
18477354 2008
19
Iron deficiency in young Lebanese children: association with elevated blood lead levels. 53 62
18458574 2008
20
Preventive effect of lactoferrin intake on anemia in female long distance runners. 53 62
18391460 2008
21
Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. 53 62
18446719 2008
22
Iron fortification: its efficacy and safety in relation to infections. 53 62
18297896 2007
23
Features of iron deficiency anemia without increment in soluble transferrin receptor concentration. 53 62
17315212 2007
24
[The expression of TfR1 mRNA and IRP1 mRNA in the placenta from different maternal iron status]. 53 62
17877204 2007
25
[The comparison of diagnostic usefulness of transferrin determination by immunological and chemical method in iron deficiency anemia]. 53 62
17682669 2007
26
Prevalence of iron deficiency and anemia among healthy women of reproductive age in Bhaktapur, Nepal. 53 62
16929243 2007
27
Nonhematological benefits of iron. 53 62
17804903 2007
28
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice. 53 62
17003376 2007
29
[Study on serum erythropoietin levels in patients with hematologic malignancies]. 53 62
17172129 2006
30
The interaction between heart failure and other heart diseases, renal failure, and anemia. 53 62
16949468 2006
31
Adjusting i.v. iron and EPO doses in patients on hemodialysis prior to continuing surgery: can we protect our patients education from iron-deficiency anemia? 53 62
17002001 2006
32
Gastric antral vascular ectasia (watermelon stomach) in patients with ESRD. 53 62
16731286 2006
33
Iron indices: what do they really mean? 53 62
16830699 2006
34
Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency. 53 62
16503547 2006
35
Carbohydrate-deficient isoforms of transferrin (%CDT) and sialic acid (SA) in iron-deficiency anemia. 53 62
16178908 2005
36
Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia. 53 62
15820481 2005
37
Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children. 53 62
15755831 2005
38
Comparison of the serum erythropoietin levels in chemotherapy-naive and cisplatin-treated cancer patients. 53 62
15739025 2005
39
Iron status of the Taiwanese elderly: the prevalence of iron deficiency and elevated iron stores. 53 62
16169840 2005
40
Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis. 53 62
15843240 2005
41
The soluble transferrin receptor (sTfR)-ferritin index is a potential predictor of celiac disease in children with refractory iron deficiency anemia. 53 62
15653440 2005
42
Serum transferrin receptor levels in beta-thalassemia trait. 53 62
15537726 2004
43
Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method. 53 62
15531698 2004
44
Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. 53 62
15222487 2004
45
Factors associated with iron deficiency anemia in Brazilian preschool children. 53 62
15192767 2004
46
Prevalence of iron depletion and anemia in top-level basketball players. 53 62
15129928 2004
47
[Conventional and new laboratory parameters in the evaluation of hematologic disease]. 53 62
15018392 2004
48
EPO and TPO sequences do not explain thrombocytosis in iron deficiency anemia. 53 62
14608206 2003
49
Contribution of iron deficiency to anemia in chronic renal failure. 53 62
15025343 2003
50
Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. 53 62
12885710 2003

Variations for Iron Deficiency Anemia

ClinVar genetic disease variations for Iron Deficiency Anemia:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TF NM_001063.4(TF):c.829G>A (p.Gly277Ser) SNV Uncertain Significance
12622 rs1799899 GRCh37: 3:133475812-133475812
GRCh38: 3:133756968-133756968

Expression for Iron Deficiency Anemia

Search GEO for disease gene expression data for Iron Deficiency Anemia.

Pathways for Iron Deficiency Anemia

Pathways related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 CP FTL HEPH HFE SLC11A2 SLC40A1
2
Show member pathways
12.3 SLC40A1 SLC11A2 HEPH CP
3
Show member pathways
11.86 SLC40A1 SLC11A2 HEPH CP
4 11.82 TNF THPO IL6 EPO
5 11.56 TNF IL6 CRP
6 11.52 TFRC TF EPO CP
7
Show member pathways
11.51 TFRC TFR2 TF SLC40A1 SLC11A2 HFE
8 11.45 TFRC TF SLC40A1 HFE HAMP
9 11.37 TF IL6 EPO
10 11.24 TFRC TF SLC40A1 SLC11A2 FTL CP
11 10.89 TNF IL6 CRP
12 10.63 TNF FTL
13 10.4 TFR2 SLC40A1 SLC11A2
14 10.3 TMPRSS6 HJV HFE HAMP
15
Show member pathways
10.22 TNF IL6
16
Show member pathways
10.1 SLC40A1 CP

GO Terms for Iron Deficiency Anemia

Cellular components related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.45 TNF THPO TFRC TF LTF IL6
2 extracellular space GO:0005615 10.27 CP CRP EPO HAMP HFE HJV
3 cell surface GO:0009986 10.17 TNF TFRC TF SLC11A2 LTF HJV
4 blood microparticle GO:0072562 9.97 CP HBG2 TF TFRC
5 basal part of cell GO:0045178 9.73 HFE SLC11A2 TF
6 recycling endosome GO:0055037 9.73 TNF TFRC TF SLC11A2 LTF HFE
7 HFE-transferrin receptor complex GO:1990712 9.32 TFRC TFR2 TF HJV HFE

Biological processes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular iron ion homeostasis GO:0006879 10.23 CP FTL HAMP HEPH HFE HJV
2 acute-phase response GO:0006953 10.03 CRP EPO HAMP IL6 TFR2 TFRC
3 osteoclast differentiation GO:0030316 10.02 TNF TFRC TF
4 monoatomic ion transport GO:0006811 10.02 TF SLC40A1 SLC11A2 LTF HFE HEPH
5 response to iron ion GO:0010039 10.02 TFRC TFR2 SLC11A2 HFE HAMP
6 liver regeneration GO:0097421 10.01 TNF IL6 HAMP
7 iron ion homeostasis GO:0055072 10 CP FTL HAMP HEPH HFE HJV
8 copper ion transport GO:0006825 9.97 SLC11A2 HEPH CP
9 multicellular organismal iron ion homeostasis GO:0060586 9.97 SLC40A1 SLC11A2 HFE HAMP
10 iron ion transmembrane transport GO:0034755 9.93 HAMP SLC11A2 SLC40A1
11 negative regulation of lipid storage GO:0010888 9.91 TNF IL6 CRP
12 cellular response to iron ion GO:0071281 9.88 TFR2 TF HFE
13 response to iron ion starvation GO:1990641 9.83 HFE HAMP
14 regulation of iron ion transport GO:0034756 9.81 TF HFE
15 iron ion transport GO:0006826 9.55 CP FTL HEPH LTF SLC11A2 SLC40A1

Molecular functions related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ferrous iron binding GO:0008198 9.63 TF HEPH FTL
2 ferrous iron transmembrane transporter activity GO:0015093 9.62 SLC40A1 SLC11A2
3 ferroxidase activity GO:0004322 9.56 HEPH CP
4 transferrin receptor activity GO:0004998 9.26 TFRC TFR2
5 transferrin receptor binding GO:1990459 9.1 TF HJV HFE

Sources for Iron Deficiency Anemia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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