MCID: IRN002
MIFTS: 60

Iron Metabolism Disease

Categories: Blood diseases, Immune diseases, Metabolic diseases, Respiratory diseases

Aliases & Classifications for Iron Metabolism Disease

Summaries for Iron Metabolism Disease

MedlinePlus : 44 Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes. Your body needs the right amount of iron. If you have too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods. Too much iron can damage your body. Taking too many iron supplements can cause iron poisoning. Some people have an inherited disease called hemochromatosis. It causes too much iron to build up in the body. Centers for Disease Control and Prevention

MalaCards based summary : Iron Metabolism Disease, also known as iron deficiency, is related to iron-refractory iron deficiency anemia and siderosis. An important gene associated with Iron Metabolism Disease is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glucose / Energy Metabolism. The drugs Copper and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Iron deficiency, or sideropaenia, is the state in which a body lacks enough iron to supply its needs.... more...

Related Diseases for Iron Metabolism Disease

Diseases related to Iron Metabolism Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1156)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.4 EPO HJV
2 siderosis 32.5 HFE SLC40A1 TF TFRC
3 iron deficiency anemia 32.5 EPO HFE HJV SLC11A2 SLC40A1 TF
4 ancylostomiasis 32.2 CP TF
5 myelodysplastic syndrome 31.7 EPO HFE TF TFRC
6 hemochromatosis, type 3 31.6 HFE HJV SLC40A1 TFR2
7 hemochromatosis, type 4 31.4 HFE HJV SLC40A1 TF TFR2
8 thalassemia 30.8 EPO HFE TF TFRC
9 aceruloplasminemia 30.8 CP HFE HJV TF TFR2
10 atransferrinemia 30.3 CP HFE HJV SLC11A2 SLC40A1 TF
11 hemosiderosis 30.3 CP EPO HFE SLC11A2 SLC40A1 TF
12 hemoglobinopathy 30.2 EPO HFE TF
13 hyperferritinemia with or without cataract 30.1 HFE TF
14 vitamin b12 deficiency 30.1 EPO TF
15 beta-thalassemia 30.0 EPO HFE TF TFR2 TFRC
16 wilson disease 29.8 CP HFE TF
17 deficiency anemia 29.8 CP EPO HFE HJV SLC11A2 SLC40A1
18 iron overload in africa 29.8 HFE SLC40A1 TF TFR2 TFRC
19 hemochromatosis type 2 29.8 HFE HJV SLC40A1 TF TFR2
20 hemochromatosis, type 1 29.7 CP CYBRD1 HFE HJV IREB2 SLC11A2
21 acquired polycythemia 29.7 EPO TF
22 porphyria cutanea tarda 29.6 HFE TF TFRC
23 eales disease 29.6 CP TF
24 hypochromic microcytic anemia 29.5 CP SLC11A2 TF
25 pure red-cell aplasia 29.5 EPO TF
26 liver disease 29.5 CP HFE TF
27 hemoglobin h disease 29.5 EPO TF TFRC
28 protein-energy malnutrition 29.1 CP TF
29 microcytic anemia 28.9 EPO IREB2 SLC11A2 TF TFRC
30 inherited metabolic disorder 28.8 HFE HJV TF TFR2
31 neurodegeneration with brain iron accumulation 5 12.6
32 neurodegeneration with brain iron accumulation 1 12.6
33 neurodegeneration with brain iron accumulation 12.6
34 neurodegeneration with brain iron accumulation 4 12.5
35 hypochromic microcytic anemia with iron overload 12.5
36 neurodegeneration with brain iron accumulation 6 12.5
37 neurodegeneration with brain iron accumulation 2b 12.5
38 neurodegeneration with brain iron accumulation 3 12.5
39 neurodegeneration with brain iron accumulation 2a 12.5
40 neurodegeneration with brain iron accumulation 7 12.4
41 neurodegeneration with brain iron accumulation 8 12.4
42 anemia, hypochromic microcytic, with iron overload 2 12.3
43 myopathy with deficiency of iron-sulfur cluster assembly enzyme 12.2
44 gracile syndrome 12.0
45 irons bhan syndrome 12.0
46 mitochondrial membrane protein-associated neurodegeneration 12.0
47 genetic hyperferritinemia without iron overload 12.0
48 sideroblastic anemia 11.9
49 plummer vinson syndrome 11.7
50 myopathy with lactic acidosis, hereditary 11.7

Comorbidity relations with Iron Metabolism Disease via Phenotypic Disease Network (PDN):


Deficiency Anemia Pulmonary Hemosiderosis

Graphical network of the top 20 diseases related to Iron Metabolism Disease:



Diseases related to Iron Metabolism Disease

Symptoms & Phenotypes for Iron Metabolism Disease

MGI Mouse Phenotypes related to Iron Metabolism Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CP EPO HFE HJV IREB2 SLC11A2
2 homeostasis/metabolism MP:0005376 10.06 CP CYBRD1 EPO HFE HJV IREB2
3 cardiovascular system MP:0005385 10.01 CP CYBRD1 EPO HJV IREB2 SLC11A2
4 immune system MP:0005387 9.91 CP EPO HFE HJV IREB2 SLC11A2
5 liver/biliary system MP:0005370 9.65 CP CYBRD1 EPO HFE HJV IREB2
6 integument MP:0010771 9.63 EPO HJV IREB2 SLC11A2 SLC40A1 TFRC
7 mortality/aging MP:0010768 9.23 EPO HFE HJV IREB2 SLC11A2 SLC40A1

Drugs & Therapeutics for Iron Metabolism Disease

Drugs for Iron Metabolism Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 289)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Copper Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-50-8 27099
2
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 1406-66-2 14986
3
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6, 15438-31-0 27284 23925
4
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
5
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 7440-66-6 32051
6
Ferrous gluconate Approved Phase 4,Phase 1,Not Applicable 299-29-6
7
Ferrous succinate Approved Phase 4,Phase 2 10030-90-7
8
Ferrous fumarate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 141-01-5
9
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 13422-55-4
10
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 15589840 11953898
11
Halofantrine Approved Phase 4 69756-53-2 37393
12
Nicotinamide Approved, Investigational Phase 4,Phase 3,Not Applicable 98-92-0 936
13
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
14
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7782-49-2
15
tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1401-55-4
16
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
17
Iron isomaltoside 1000 Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1370654-58-2
18
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
19
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
20
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68-04-2
21
Clarithromycin Approved Phase 4 81103-11-9 84029
22 Iron protein succinylate Approved, Investigational Phase 4,Not Applicable 250705-13-6
23
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
24
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 54670067 5785
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
26
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 59-02-9 14985
27
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
28
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
29
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
30
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
31
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 68-19-9 44176380
32
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
33
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 70-16-6, 59-43-8 1130
34
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 65-23-6 1054
35
Vitamin D3 Approved, Nutraceutical Phase 4,Not Applicable 67-97-0 5280795 6221
36
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 59-67-6 938
37
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 83-88-5 493570
38
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
39 Tocotrienol Investigational Phase 4,Phase 3,Phase 1,Not Applicable 6829-55-6
40
Cobalamin Experimental Phase 4,Phase 2,Phase 3,Not Applicable 13408-78-1 6857388
41 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Tocopherols Phase 4,Phase 3,Phase 1,Not Applicable
45 Tocotrienols Phase 4,Phase 3,Phase 1,Not Applicable
46 Nutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Folate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Iron Supplement Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Antioxidants Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 650)
# Name Status NCT ID Phase Drugs
1 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
2 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
3 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
4 Treatment Response of Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass Unknown status NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
5 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
6 Iron Deficiency In Pulmonary Hypertension Unknown status NCT01288651 Phase 4 Ferricarboxymaltose
7 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
8 Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance In Non Anemic Premenopausal Women With Low Ferritin Levels Unknown status NCT01374776 Phase 4 Double blind, randomized, placebo controlled inter
9 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
10 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
11 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
12 Intravenous Iron for Correction of Anaemia After Colorectal Surgery Unknown status NCT02999217 Phase 4 Iron isomaltoside;Saline
13 Iron Absorption Trial Unknown status NCT02228902 Phase 4 Ferrous fumarate;Ferrous gluconate
14 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
15 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Completed NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
16 Iron Treatment for Young Children With Non-anemic Iron Deficiency Completed NCT01481766 Phase 4
17 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
18 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
19 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
20 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
21 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
22 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
23 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
24 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
25 the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients Completed NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
26 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
27 Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
28 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
29 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
30 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
31 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
32 Iron Substitution in Blood Donors Completed NCT01519830 Phase 4 Iron carboxymaltose (Ferinject);Placebo
33 Optimizing Iron Suppletion After Roux-en-Y Gastric Bypass Completed NCT02271997 Phase 4 Ferrous fumarate;Ferrous gluconate;Iron(III)carboxymaltose
34 Oral Lactoferrin Versus Iron Supplementation During Pregnancy Completed NCT03542825 Phase 4 Lactoferrin;Iron Supplement;Chelates, Iron
35 Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age Completed NCT01110356 Phase 4 Ferinject
36 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
37 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
38 FLIPS: Ferfer Liposomal Iron Performance Study Completed NCT03112187 Phase 4 Iron Supplement
39 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
40 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
41 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
42 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
43 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
44 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
45 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
46 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
47 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
48 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
49 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
50 Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study) Completed NCT01609387 Phase 4

Search NIH Clinical Center for Iron Metabolism Disease

Cochrane evidence based reviews: iron metabolism disorders

Genetic Tests for Iron Metabolism Disease

Anatomical Context for Iron Metabolism Disease

MalaCards organs/tissues related to Iron Metabolism Disease:

42
Heart, Kidney, Brain, Liver, Bone, Testes, Thyroid

Publications for Iron Metabolism Disease

Articles related to Iron Metabolism Disease:

(show top 50) (show all 4424)
# Title Authors Year
1
A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia. ( 31057960 )
2019
2
Studying anemia of chronic disease and iron deficiency in patients with rheumatoid arthritis by iron status and circulating hepcidin. ( 30996848 )
2019
3
The links of hepcidin and erythropoietin in the interplay of inflammation and iron deficiency in a large observational study of rheumatoid arthritis. ( 30941747 )
2019
4
Restless legs syndrome and iron deficiency in adults with attention deficit hyperactivity disorder. ( 30722056 )
2019
5
Challenges in the Treatment of Iron Deficiency Anemia in a Child With Autism Spectrum Disorder: A Case Study. ( 30683579 )
2019
6
Associations between non-anaemic iron deficiency and outcomes following surgery for colorectal cancer: An exploratory study of outcomes relevant to prospective observational studies. ( 31090438 )
2019
7
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma. ( 29955854 )
2019
8
Perspectives on anemia and iron deficiency from the cystic fibrosis care community. ( 30924325 )
2019
9
Anaemia and iron deficiency in relation to fatigue in cystic fibrosis. ( 30195412 )
2019
10
Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample. ( 30845224 )
2019
11
Association of Zinc Deficiency with Iron Deficiency Anemia and its Symptoms: Results from a Case-control Study. ( 30868025 )
2019
12
Iron Deficiency Anemia Due to High-dose Turmeric. ( 30899609 )
2019
13
Antioxidant, immunomodulatory, oxidative stress inhibitory and iron supplementation effect of Astragalus membranaceus polysaccharide-iron (III) complex on iron-deficiency anemia mouse model. ( 30926500 )
2019
14
Intravenous Iron Versus Placebo in the Management of Postoperative Functional Iron Deficiency Anemia in Patients Undergoing Cardiac Valvular Surgery: A Prospective, Single-Blinded, Randomized Controlled Trial. ( 30930140 )
2019
15
Effect of Helicobacter pylori Treatment on Unexplained Iron Deficiency Anemia. ( 30939286 )
2019
16
Efficacy of SXN in the Treatment of Iron Deficiency Anemia: A Phase IV Clinical Trial. ( 30941201 )
2019
17
Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children. ( 30944864 )
2019
18
Correction: Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample. ( 30947306 )
2019
19
Correction: Association of Zinc Deficiency with Iron Deficiency Anemia and its Symptoms: Results from a Case-control Study. ( 30967984 )
2019
20
Iron Deficiency Anemia in Chronic Kidney Disease. ( 30970355 )
2019
21
Management of Perioperative Iron Deficiency Anemia. ( 30970362 )
2019
22
Pagophagia in men with iron-deficiency anemia. ( 30986649 )
2019
23
Feralgine™ a New Approach for Iron Deficiency Anemia in Celiac Patients. ( 31009990 )
2019
24
Iron Deficiency Anemia among In-School Adolescent Girls in Rural Area of Bahir Dar City Administration, North West Ethiopia. ( 31016041 )
2019
25
Recognizing missed opportunities to diagnose and treat iron deficiency anemia: A study based on prevalence of anemia among children in a teaching hospital. ( 31041221 )
2019
26
Gender differences in determinants of iron-deficiency anemia: a population-based study conducted in four European countries. ( 31073646 )
2019
27
Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia. ( 31086504 )
2019
28
Groundwater iron has the ground: Low prevalence of anemia and iron deficiency anemia in Bangladesh. ( 31095289 )
2019
29
Association between Helicobacter pylori Infection and Iron Deficiency Anemia in School-aged Iranian Children. ( 31102380 )
2019
30
The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia. ( 31104454 )
2019
31
Iron-deficiency Anemia Causes an Ischemic Stroke in a Young Man. ( 31106101 )
2019
32
Cerebral venous sinus thrombosis and iron deficiency anemia presenting as bilateral disc edema in a child. ( 31109492 )
2019
33
Comparison of efficacy and safety between intravenous ferric carboxymaltose and saccharated ferric oxide in Japanese patients with iron-deficiency anemia due to hypermenorrhea: a multi-center, randomized, open-label noninferiority study. ( 30039442 )
2019
34
Peutz-Jeghers Syndrome: A Very Rare Cause of Iron Deficiency Anemia ( 30040067 )
2019
35
Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis. ( 30121943 )
2019
36
Safety and efficacy of intravenous ferric carboxymaltose in Japanese patients with iron-deficiency anemia caused by digestive diseases: an open-label, single-arm study. ( 30194568 )
2019
37
Association of maternal iron deficiency anemia with the risk of gestational diabetes mellitus: a meta-analysis. ( 30315412 )
2019
38
Serum and Urinary Hepcidin for Diagnosing Iron-deficiency Anemia in Under-5 Children. ( 30334902 )
2019
39
Diagnostic yield of magnetically assisted capsule endoscopy versus gastroscopy in recurrent and refractory iron deficiency anemia. ( 30360012 )
2019
40
Safety and efficacy of sucrosomial iron in inflammatory bowel disease patients with iron deficiency anemia. ( 30499070 )
2019
41
Iron Deficiency Anemia Associated With Acid-Modifying Medications: Two Cases and Literature Review. ( 30528320 )
2019
42
Soluble transferrin receptor and soluble transferrin receptor/log ferritin index in diagnosis of iron deficiency anemia in pediatric inflammatory bowel disease. ( 30538074 )
2019
43
Structure characterization of low molecular weight sulfate Ulva polysaccharide and the effect of its derivative on iron deficiency anemia. ( 30584945 )
2019
44
The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women. ( 30630976 )
2019
45
Distinguishing iron deficiency anemia from thalassemia by the red blood cell lifespan with a simple CO breath test: a pilot study. ( 30641506 )
2019
46
Associations between iron deficiency anemia and clinical features among pregnant women: a prospective cohort study [Retraction]. ( 30643474 )
2019
47
Effect of iron deficiency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia. ( 30647919 )
2019
48
Effect of microalgae as iron supplements on iron-deficiency anemia in rats. ( 30664135 )
2019
49
A systematic literature review and indirect comparison of iron isomaltoside and ferric carboxymaltose in iron deficiency anemia after failure or intolerance of oral iron treatment. ( 30689458 )
2019
50
Intravenous compared with oral iron for the treatment of iron-deficiency anemia in pregnancy: a systematic review and meta-analysis. ( 30692612 )
2019

Variations for Iron Metabolism Disease

Expression for Iron Metabolism Disease

Search GEO for disease gene expression data for Iron Metabolism Disease.

Pathways for Iron Metabolism Disease

Pathways related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
2 12.18 CP IREB2 SLC11A2
3
Show member pathways
12.08 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
4 11.63 EPO TF TFRC
5
Show member pathways
11.59 CP SLC11A2 SLC40A1
6 11.44 CP EPO TF TFRC
7 11.27 CYBRD1 SLC11A2 SLC40A1 TF
8 11.18 EPO TF
9 11.01 EPO SLC11A2
10 10.96 CP SLC11A2 SLC40A1 TF TFRC
11 10.21 HFE HJV
12 10.18 IREB2 SLC11A2 SLC40A1 TF TFR2 TFRC

GO Terms for Iron Metabolism Disease

Cellular components related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 CP EPO HFE HJV TF TFRC
2 integral component of plasma membrane GO:0005887 9.89 HFE SLC11A2 SLC40A1 TFR2 TFRC
3 perinuclear region of cytoplasm GO:0048471 9.78 HFE SLC11A2 TF TFRC
4 cytoplasmic vesicle GO:0031410 9.77 HFE SLC11A2 TF TFR2 TFRC
5 cell surface GO:0009986 9.72 EPO HJV SLC11A2 TF TFRC
6 lysosomal membrane GO:0005765 9.7 CP CYBRD1 SLC11A2
7 endosome membrane GO:0010008 9.63 SLC11A2 TF TFRC
8 blood microparticle GO:0072562 9.58 CP TF TFRC
9 early endosome GO:0005769 9.56 HFE SLC11A2 TF TFRC
10 extracellular vesicle GO:1903561 9.55 SLC11A2 TFRC
11 brush border membrane GO:0031526 9.54 CYBRD1 SLC11A2
12 clathrin-coated vesicle membrane GO:0030665 9.51 TF TFRC
13 recycling endosome GO:0055037 9.46 HFE SLC11A2 TF TFRC
14 basal part of cell GO:0045178 9.13 HFE SLC11A2 TF
15 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC

Biological processes related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.85 CP HFE SLC11A2 SLC40A1 TF
2 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
3 acute-phase response GO:0006953 9.61 EPO HFE TFR2
4 multicellular organismal iron ion homeostasis GO:0060586 9.58 HFE SLC11A2 SLC40A1
5 response to iron ion GO:0010039 9.56 CYBRD1 HFE SLC11A2 TFR2
6 iron ion transport GO:0006826 9.55 IREB2 SLC11A2 SLC40A1 TF TFR2
7 cellular response to iron ion GO:0071281 9.54 HFE TF TFR2
8 osteoclast differentiation GO:0030316 9.52 IREB2 TFRC
9 positive regulation of receptor-mediated endocytosis GO:0048260 9.51 HFE TF
10 copper ion transport GO:0006825 9.49 CP SLC11A2
11 positive regulation of peptide hormone secretion GO:0090277 9.48 HFE TFR2
12 iron ion homeostasis GO:0055072 9.43 HFE HJV SLC11A2 SLC40A1 TF TFR2
13 cellular iron ion homeostasis GO:0006879 9.32 CP CYBRD1 HFE HJV IREB2 SLC11A2

Molecular functions related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 9.37 HFE TFR2
2 iron ion transmembrane transporter activity GO:0005381 9.32 SLC11A2 SLC40A1
3 ferrous iron transmembrane transporter activity GO:0015093 9.26 SLC11A2 SLC40A1
4 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
5 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
6 transferrin receptor binding GO:1990459 8.8 HFE HJV TF

Sources for Iron Metabolism Disease

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