IRON
MCID: IRN002
MIFTS: 60

Iron Metabolism Disease (IRON)

Categories: Blood diseases, Immune diseases, Metabolic diseases, Respiratory diseases

Aliases & Classifications for Iron Metabolism Disease

Summaries for Iron Metabolism Disease

MedlinePlus : 44 Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes. Your body needs the right amount of iron. If you have too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods. Too much iron can damage your body. Taking too many iron supplements can cause iron poisoning. Some people have an inherited disease called hemochromatosis. It causes too much iron to build up in the body. Centers for Disease Control and Prevention

MalaCards based summary : Iron Metabolism Disease, also known as iron deficiency, is related to iron-refractory iron deficiency anemia and siderosis. An important gene associated with Iron Metabolism Disease is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glucose / Energy Metabolism. The drugs Copper and Zinc have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Iron deficiency, or sideropaenia, is the state in which a body lacks enough iron to supply its needs.... more...

Related Diseases for Iron Metabolism Disease

Diseases related to Iron Metabolism Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1106)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.3 EPO HJV
2 siderosis 32.5 HFE SLC40A1 TF TFRC
3 iron deficiency anemia 32.4 EPO HFE HJV SLC11A2 SLC40A1 TF
4 ancylostomiasis 32.1 CP TF
5 myelodysplastic syndrome 31.7 EPO HFE TF TFRC
6 hemochromatosis, type 3 31.6 HFE HJV SLC40A1 TFR2
7 hemochromatosis, type 4 31.4 HFE HJV SLC40A1 TF TFR2
8 thalassemia 30.8 EPO HFE TF TFRC
9 aceruloplasminemia 30.7 CP HFE HJV TF TFR2
10 atransferrinemia 30.3 CP HFE HJV SLC11A2 SLC40A1 TF
11 hemosiderosis 30.3 CP EPO HFE SLC11A2 SLC40A1 TF
12 hemoglobinopathy 30.2 EPO HFE TF
13 hyperferritinemia with or without cataract 30.1 HFE TF
14 vitamin b12 deficiency 30.1 EPO TF
15 beta-thalassemia 29.9 EPO HFE TF TFR2 TFRC
16 deficiency anemia 29.8 CP EPO HFE HJV SLC11A2 SLC40A1
17 wilson disease 29.8 CP HFE TF
18 iron overload in africa 29.8 HFE SLC40A1 TF TFR2 TFRC
19 hemochromatosis type 2 29.8 HFE HJV SLC40A1 TF TFR2
20 acquired polycythemia 29.7 EPO TF
21 porphyria cutanea tarda 29.6 HFE TF TFRC
22 eales disease 29.5 CP TF
23 liver disease 29.5 CP HFE TF
24 hypochromic microcytic anemia 29.5 CP SLC11A2 TF
25 pure red-cell aplasia 29.5 EPO TF
26 hemoglobin h disease 29.5 EPO TF TFRC
27 hemochromatosis, type 1 29.4 CP CYBRD1 HFE HJV IREB2 SLC11A2
28 protein-energy malnutrition 29.1 CP TF
29 microcytic anemia 28.9 EPO IREB2 SLC11A2 TF TFRC
30 inherited metabolic disorder 28.8 HFE HJV TF TFR2
31 neurodegeneration with brain iron accumulation 1 12.6
32 neurodegeneration with brain iron accumulation 5 12.6
33 neurodegeneration with brain iron accumulation 12.6
34 neurodegeneration with brain iron accumulation 4 12.5
35 hypochromic microcytic anemia with iron overload 12.5
36 neurodegeneration with brain iron accumulation 3 12.5
37 neurodegeneration with brain iron accumulation 6 12.4
38 neurodegeneration with brain iron accumulation 2b 12.4
39 neurodegeneration with brain iron accumulation 2a 12.4
40 anemia, hypochromic microcytic, with iron overload 2 12.3
41 neurodegeneration with brain iron accumulation 7 12.3
42 neurodegeneration with brain iron accumulation 8 12.3
43 myopathy with deficiency of iron-sulfur cluster assembly enzyme 12.2
44 gracile syndrome 12.0
45 irons bhan syndrome 12.0
46 mitochondrial membrane protein-associated neurodegeneration 12.0
47 genetic hyperferritinemia without iron overload 11.9
48 sideroblastic anemia 11.8
49 plummer vinson syndrome 11.7
50 coasy protein-associated neurodegeneration 11.6

Comorbidity relations with Iron Metabolism Disease via Phenotypic Disease Network (PDN):


Deficiency Anemia Pulmonary Hemosiderosis

Graphical network of the top 20 diseases related to Iron Metabolism Disease:



Diseases related to Iron Metabolism Disease

Symptoms & Phenotypes for Iron Metabolism Disease

MGI Mouse Phenotypes related to Iron Metabolism Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CP EPO HFE HJV IREB2 SLC11A2
2 homeostasis/metabolism MP:0005376 10.06 CP CYBRD1 EPO HFE HJV IREB2
3 cardiovascular system MP:0005385 10.01 CP CYBRD1 EPO HJV IREB2 SLC11A2
4 immune system MP:0005387 9.91 CP EPO HFE HJV IREB2 SLC11A2
5 liver/biliary system MP:0005370 9.65 CP CYBRD1 EPO HFE HJV IREB2
6 integument MP:0010771 9.63 EPO HJV IREB2 SLC11A2 SLC40A1 TFRC
7 mortality/aging MP:0010768 9.23 EPO HFE HJV IREB2 SLC11A2 SLC40A1

Drugs & Therapeutics for Iron Metabolism Disease

Drugs for Iron Metabolism Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 288)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Copper Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-50-8 27099
2
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 7440-66-6 32051
3
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6, 15438-31-0 23925 27284
4
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
5
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 1406-66-2 14986
6
Ferrous gluconate Approved Phase 4,Phase 1,Not Applicable 299-29-6
7
Ferrous succinate Approved Phase 4,Phase 2 10030-90-7
8
Ferrous fumarate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 141-01-5
9
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 13422-55-4
10
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 15589840
11
Halofantrine Approved Phase 4 69756-53-2 37393
12
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
13
Nicotinamide Approved, Investigational Phase 4,Phase 3,Not Applicable 98-92-0 936
14
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7782-49-2
15
tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1401-55-4
16
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
17
Iron isomaltoside 1000 Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1370654-58-2
18
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
19
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
20
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68-04-2
21
Clarithromycin Approved Phase 4 81103-11-9 84029
22 Iron protein succinylate Approved, Investigational Phase 4,Not Applicable 250705-13-6
23
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
24
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 59-02-9 14985
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
26
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 5785 54670067
27
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
28
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
29
Vitamin D3 Approved, Nutraceutical Phase 4,Not Applicable 67-97-0 5280795 6221
30
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
31
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
32
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 68-19-9 44176380
33
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
34
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 65-23-6 1054
35
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 83-88-5 493570
36
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 59-67-6 938
37
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
38
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
39 Tocotrienol Investigational Phase 4,Phase 3,Phase 1,Not Applicable 6829-55-6
40
Cobalamin Experimental Phase 4,Phase 2,Phase 3,Not Applicable 13408-78-1 6857388
41 Antioxidants Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
42 Tocopherols Phase 4,Phase 3,Phase 1,Not Applicable
43 Nutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Iron Supplement Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Tocotrienols Phase 4,Phase 3,Phase 1,Not Applicable
49 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Vitamin B9 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 640)
# Name Status NCT ID Phase Drugs
1 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
2 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
3 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
4 Treatment Response of Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass Unknown status NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
5 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
6 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
7 Iron Deficiency In Pulmonary Hypertension Unknown status NCT01288651 Phase 4 Ferricarboxymaltose
8 Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance In Non Anemic Premenopausal Women With Low Ferritin Levels Unknown status NCT01374776 Phase 4 Double blind, randomized, placebo controlled inter
9 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
10 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
11 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
12 Intravenous Iron for Correction of Anaemia After Colorectal Surgery Unknown status NCT02999217 Phase 4 Iron isomaltoside;Saline
13 Iron Absorption Trial Unknown status NCT02228902 Phase 4 Ferrous fumarate;Ferrous gluconate
14 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
15 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Completed NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
16 Iron Treatment for Young Children With Non-anemic Iron Deficiency Completed NCT01481766 Phase 4
17 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
18 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
19 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
20 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
21 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
22 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
23 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
24 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
25 the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients Completed NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
26 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
27 Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
28 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
29 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
30 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
31 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
32 Iron Substitution in Blood Donors Completed NCT01519830 Phase 4 Iron carboxymaltose (Ferinject);Placebo
33 Optimizing Iron Suppletion After Roux-en-Y Gastric Bypass Completed NCT02271997 Phase 4 Ferrous fumarate;Ferrous gluconate;Iron(III)carboxymaltose
34 Oral Lactoferrin Versus Iron Supplementation During Pregnancy Completed NCT03542825 Phase 4 Lactoferrin;Iron Supplement;Chelates, Iron
35 Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age Completed NCT01110356 Phase 4 Ferinject
36 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
37 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
38 FLIPS: Ferfer Liposomal Iron Performance Study Completed NCT03112187 Phase 4 Iron Supplement
39 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
40 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
41 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
42 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
43 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
44 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
45 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
46 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
47 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
48 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
49 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
50 Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study) Completed NCT01609387 Phase 4

Search NIH Clinical Center for Iron Metabolism Disease

Cochrane evidence based reviews: iron metabolism disorders

Genetic Tests for Iron Metabolism Disease

Anatomical Context for Iron Metabolism Disease

MalaCards organs/tissues related to Iron Metabolism Disease:

42
Heart, Kidney, Testes, Brain, Lung, Liver, Bone

Publications for Iron Metabolism Disease

Articles related to Iron Metabolism Disease:

(show top 50) (show all 4354)
# Title Authors Year
1
Restless legs syndrome and iron deficiency in adults with attention deficit hyperactivity disorder. ( 30722056 )
2019
2
Challenges in the Treatment of Iron Deficiency Anemia in a Child With Autism Spectrum Disorder: A Case Study. ( 30683579 )
2019
3
Anaemia and iron deficiency in relation to fatigue in cystic fibrosis. ( 30195412 )
2019
4
Iron Deficiency Anemia Associated With Acid-Modifying Medications: Two Cases and Literature Review. ( 30528320 )
2019
5
Favourable improvement in haematological parameters in response to oral iron and vitamin C combination in children with Iron Refractory Iron Deficiency Anemia (IRIDA) phenotype. ( 30594846 )
2019
6
The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women. ( 30630976 )
2019
7
Distinguishing iron deficiency anemia from thalassemia by the red blood cell lifespan with a simple CO breath test: a pilot study. ( 30641506 )
2019
8
Associations between iron deficiency anemia and clinical features among pregnant women: a prospective cohort study [Retraction]. ( 30643474 )
2019
9
Effect of iron deficiency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia. ( 30647919 )
2019
10
Effect of microalgae as iron supplements on iron-deficiency anemia in rats. ( 30664135 )
2019
11
A systematic literature review and indirect comparison of iron isomaltoside and ferric carboxymaltose in iron deficiency anaemia after failure or intolerance of oral iron treatment. ( 30689458 )
2019
12
Intravenous compared with oral iron for the treatment of iron-deficiency anemia in pregnancy: a systematic review and meta-analysis. ( 30692612 )
2019
13
Preventing Iron Deficiency Anemia During Pregnancy. ( 30695164 )
2019
14
Correction: Mateusz, S., et al. Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia. Pharmaceuticals 2018, 11, 128. ( 30699979 )
2019
15
Good clinical practice advice: Iron deficiency anemia in pregnancy. ( 30710364 )
2019
16
Reported Outcomes in Perinatal Iron Deficiency Anemia Trials: A Systematic Review. ( 30712041 )
2019
17
Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial. ( 30717690 )
2019
18
Response: patient blood management strategies for iron-deficiency anemia management in gastric cancer. ( 30720606 )
2019
19
Role of Soluble Transferrin Receptor and Transferrin Receptor-Ferritin Index to Detect Iron Deficiency Anemia in Regular Hemodialysis Patients. ( 30740169 )
2019
20
Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease. ( 30744317 )
2019
21
Iron deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity. ( 30779710 )
2019
22
Treatment with Noripurum EV® is effective and safe in pediatric patients with inflammatory bowel disease and iron deficiency anemia. ( 30782036 )
2019
23
An update on the evaluation and management of iron deficiency anemia in inflammatory bowel disease. ( 30791779 )
2019
24
The effect of therapy on plasma ghrelin and leptin levels, and appetite in children with iron deficiency anemia. ( 30796846 )
2019
25
Fe3O4@ Astragalus Polysaccharide Core-Shell Nanoparticles for Iron Deficiency Anemia Therapy and Magnetic Resonance Imaging In Vivo. ( 30801182 )
2019
26
Ferumoxytol for iron deficiency anemia in patients undergoing hemodialysis. The FACT randomized controlled trial
. ( 30802204 )
2019
27
The Spectrum of Small Intestinal Lesions in Patients with Unexplained Iron Deficiency Anemia Detected by Video Capsule Endoscopy. ( 30818850 )
2019
28
Patient Blood Management strategies for iron deficiency anemia management in gastric cancer. ( 30829765 )
2019
29
Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample. ( 30845224 )
2019
30
Association of Zinc Deficiency with Iron Deficiency Anemia and its Symptoms: Results from a Case-control Study. ( 30868025 )
2019
31
Iron Deficiency Anemia Due to High-dose Turmeric. ( 30899609 )
2019
32
Recurrent Severe Iron Deficiency Anemia and Thrombocytopenia in an Adolescent Male. ( 29668536 )
2019
33
Correction to: Intravenous Ferric Carboxymaltose in Patients with Type 2 Diabetes Mellitus and Iron Deficiency: CLEVER Trial Study Design and Protocol. ( 30523582 )
2019
34
Utility of new red cell parameters for distinguishing functional iron deficiency from absolute iron deficiency in children with familial Mediterranean fever. ( 30624866 )
2019
35
Iron deficiency in pulmonary arterial hypertension associated with congenital heart disease. ( 30632395 )
2019
36
Ferric carboxymaltose in the treatment of iron deficiency in pediatric inflammatory bowel disease. ( 30881896 )
2019
37
TMPRSS6 rs855791 polymorphism and susceptibility to iron deficiency anaemia in non-dialysis chronic kidney disease patients in South Africa. ( 30911357 )
2019
38
Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study. ( 30700016 )
2019
39
Treatment of iron deficiency in patients with chronic kidney disease: A prospective observational study of iron isomaltoside (NIMO Scandinavia)
. ( 30614439 )
2019
40
A prospective observational study of iron isomaltoside in haemodialysis patients with chronic kidney disease treated for iron deficiency (DINO). ( 30630452 )
2019
41
Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome. ( 30311259 )
2019
42
Rare presentation of iron deficiency anaemia with cerebral venous sinus thrombosis in a middle-aged woman. ( 30659005 )
2019
43
Glycosylation Profile of the Transferrin Receptor in Gestational Iron Deficiency and Early-Onset Severe Preeclampsia. ( 30854239 )
2019
44
Acute heart failure, iron deficiency, and hyperlactataemia: a high-risk combination. ( 30912109 )
2019
45
Elevated lactate in acute heart failure patients with intracellular iron deficiency as identifier of poor outcome. ( 30740644 )
2019
46
Association Between Norepinephrine Levels and Abnormal Iron Status in Patients With Chronic Heart Failure: Is Iron Deficiency More Than a Comorbidity? ( 30760082 )
2019
47
Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients with Chronic Heart Failure and Iron Deficiency: The FERRIC-HF II Randomized Mechanistic Trial. ( 30776909 )
2019
48
Efficacy and Safety of Iron Supplementation in Patients with Heart Failure and Iron Deficiency: A Meta-analysis. ( 30782220 )
2019
49
Anemia and iron deficiency in heart failure: a review of echocardiographic features. ( 30693550 )
2019
50
Differences between intravenous iron products: focus on treatment of iron deficiency in chronic heart failure patients. ( 30694615 )
2019

Variations for Iron Metabolism Disease

Expression for Iron Metabolism Disease

Search GEO for disease gene expression data for Iron Metabolism Disease.

Pathways for Iron Metabolism Disease

Pathways related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
2 12.18 CP IREB2 SLC11A2
3
Show member pathways
12.08 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
4 11.63 EPO TF TFRC
5
Show member pathways
11.59 CP SLC11A2 SLC40A1
6 11.44 CP EPO TF TFRC
7 11.27 CYBRD1 SLC11A2 SLC40A1 TF
8 11.18 EPO TF
9 11.01 EPO SLC11A2
10 10.96 CP SLC11A2 SLC40A1 TF TFRC
11 10.21 HFE HJV
12 10.18 IREB2 SLC11A2 SLC40A1 TF TFR2 TFRC

GO Terms for Iron Metabolism Disease

Cellular components related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 CP EPO HFE HJV TF TFRC
2 integral component of plasma membrane GO:0005887 9.89 HFE SLC11A2 SLC40A1 TFR2 TFRC
3 perinuclear region of cytoplasm GO:0048471 9.78 HFE SLC11A2 TF TFRC
4 cytoplasmic vesicle GO:0031410 9.77 HFE SLC11A2 TF TFR2 TFRC
5 cell surface GO:0009986 9.72 EPO HJV SLC11A2 TF TFRC
6 lysosomal membrane GO:0005765 9.7 CP CYBRD1 SLC11A2
7 endosome membrane GO:0010008 9.63 SLC11A2 TF TFRC
8 blood microparticle GO:0072562 9.58 CP TF TFRC
9 early endosome GO:0005769 9.56 HFE SLC11A2 TF TFRC
10 extracellular vesicle GO:1903561 9.55 SLC11A2 TFRC
11 brush border membrane GO:0031526 9.54 CYBRD1 SLC11A2
12 clathrin-coated vesicle membrane GO:0030665 9.51 TF TFRC
13 recycling endosome GO:0055037 9.46 HFE SLC11A2 TF TFRC
14 basal part of cell GO:0045178 9.13 HFE SLC11A2 TF
15 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC

Biological processes related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.85 CP HFE SLC11A2 SLC40A1 TF
2 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
3 acute-phase response GO:0006953 9.61 EPO HFE TFR2
4 multicellular organismal iron ion homeostasis GO:0060586 9.58 HFE SLC11A2 SLC40A1
5 response to iron ion GO:0010039 9.56 CYBRD1 HFE SLC11A2 TFR2
6 iron ion transport GO:0006826 9.55 IREB2 SLC11A2 SLC40A1 TF TFR2
7 cellular response to iron ion GO:0071281 9.54 HFE TF TFR2
8 osteoclast differentiation GO:0030316 9.52 IREB2 TFRC
9 positive regulation of receptor-mediated endocytosis GO:0048260 9.51 HFE TF
10 copper ion transport GO:0006825 9.49 CP SLC11A2
11 positive regulation of peptide hormone secretion GO:0090277 9.48 HFE TFR2
12 iron ion homeostasis GO:0055072 9.43 HFE HJV SLC11A2 SLC40A1 TF TFR2
13 cellular iron ion homeostasis GO:0006879 9.32 CP CYBRD1 HFE HJV IREB2 SLC11A2

Molecular functions related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 9.4 HFE TFR2
2 iron ion transmembrane transporter activity GO:0005381 9.37 SLC11A2 SLC40A1
3 ferrous iron transmembrane transporter activity GO:0015093 9.32 SLC11A2 SLC40A1
4 oxidoreductase activity, oxidizing metal ions GO:0016722 9.26 CP CYBRD1
5 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
6 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
7 transferrin receptor binding GO:1990459 8.8 HFE HJV TF

Sources for Iron Metabolism Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
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