IRON
MCID: IRN002
MIFTS: 60

Iron Metabolism Disease (IRON)

Categories: Blood diseases, Immune diseases, Metabolic diseases, Respiratory diseases

Aliases & Classifications for Iron Metabolism Disease

Summaries for Iron Metabolism Disease

MedlinePlus : 43 Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes. Your body needs the right amount of iron. If you have too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods. Too much iron can damage your body. Taking too many iron supplements can cause iron poisoning. Some people have an inherited disease called hemochromatosis. It causes too much iron to build up in the body. Centers for Disease Control and Prevention

MalaCards based summary : Iron Metabolism Disease, also known as iron deficiency, is related to iron-refractory iron deficiency anemia and iron deficiency anemia. An important gene associated with Iron Metabolism Disease is TF (Transferrin), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glucose / Energy Metabolism. Affiliated tissues include heart, kidney and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Iron deficiency, or sideropaenia, is the state in which a body has not enough (or not qualitatively... more...

Related Diseases for Iron Metabolism Disease

Diseases related to Iron Metabolism Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1002)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.3 EPO HJV
2 iron deficiency anemia 33.0 EPO HFE HJV SLC11A2 SLC40A1 TF
3 siderosis 32.5 HFE SLC40A1 TF TFRC
4 ancylostomiasis 31.9 CP TF
5 myelodysplastic syndrome 31.7 EPO HFE TF TFRC
6 hemochromatosis, type 3 31.7 HFE HJV SLC40A1 TFR2
7 hemochromatosis, type 4 31.6 HFE HJV SLC40A1 TF TFR2
8 aceruloplasminemia 30.8 CP HFE HJV TF TFR2
9 thalassemia 30.8 EPO HFE TF TFRC
10 atransferrinemia 30.7 CP HFE HJV SLC11A2 SLC40A1 TF
11 hemochromatosis, type 1 30.7 CP CYBRD1 HFE HJV IREB2 SLC11A2
12 hemosiderosis 30.5 CP EPO HFE SLC11A2 SLC40A1 TF
13 deficiency anemia 30.2 CP EPO HFE HJV SLC11A2 SLC40A1
14 hemoglobinopathy 30.2 EPO HFE TF
15 vitamin b12 deficiency 30.1 EPO TF
16 beta-thalassemia 30.1 EPO HFE TF TFR2 TFRC
17 restless legs syndrome 30.0 EPO IREB2 SLC11A2 TFRC
18 iron overload in africa 30.0 HFE SLC40A1 TF TFR2 TFRC
19 hyperferritinemia with or without cataract 30.0 HFE TF
20 hemochromatosis type 2 30.0 HFE HJV SLC40A1 TF TFR2
21 wilson disease 29.7 CP HFE TF
22 acquired polycythemia 29.6 EPO TF
23 porphyria cutanea tarda 29.5 HFE TF TFRC
24 microcytic anemia 29.5 EPO IREB2 SLC11A2 TF TFRC
25 pure red-cell aplasia 29.5 EPO TF
26 hemoglobin h disease 29.5 EPO TF TFRC
27 liver disease 29.5 CP HFE TF
28 nutritional deficiency disease 29.4 CP EPO TF
29 hypochromic microcytic anemia 29.4 CP SLC11A2 TF
30 eales disease 29.4 CP TF
31 hfe-associated hereditary hemochromatosis 29.2 HFE HJV SLC11A2 TFR2
32 protein-energy malnutrition 29.1 CP TF
33 inherited metabolic disorder 28.9 HFE HJV TF TFR2
34 neurodegeneration with brain iron accumulation 1 12.5
35 neurodegeneration with brain iron accumulation 5 12.5
36 neurodegeneration with brain iron accumulation 12.5
37 neurodegeneration with brain iron accumulation 4 12.5
38 hypochromic microcytic anemia with iron overload 12.5
39 neurodegeneration with brain iron accumulation 3 12.5
40 neurodegeneration with brain iron accumulation 6 12.4
41 neurodegeneration with brain iron accumulation 2b 12.4
42 neurodegeneration with brain iron accumulation 2a 12.3
43 anemia, hypochromic microcytic, with iron overload 2 12.3
44 neurodegeneration with brain iron accumulation 7 12.2
45 neurodegeneration with brain iron accumulation 8 12.2
46 myopathy with deficiency of iron-sulfur cluster assembly enzyme 12.2
47 gracile syndrome 12.0
48 irons bhan syndrome 12.0
49 mitochondrial membrane protein-associated neurodegeneration 12.0
50 genetic hyperferritinemia without iron overload 11.9

Comorbidity relations with Iron Metabolism Disease via Phenotypic Disease Network (PDN):


Deficiency Anemia Pulmonary Hemosiderosis

Graphical network of the top 20 diseases related to Iron Metabolism Disease:



Diseases related to Iron Metabolism Disease

Symptoms & Phenotypes for Iron Metabolism Disease

MGI Mouse Phenotypes related to Iron Metabolism Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CP EPO HFE HJV IREB2 SLC11A2
2 homeostasis/metabolism MP:0005376 10.06 CP CYBRD1 EPO HFE HJV IREB2
3 cardiovascular system MP:0005385 10.01 CP CYBRD1 EPO HJV IREB2 SLC11A2
4 immune system MP:0005387 9.91 CP EPO HFE HJV IREB2 SLC11A2
5 liver/biliary system MP:0005370 9.65 CP CYBRD1 EPO HFE HJV IREB2
6 integument MP:0010771 9.63 EPO HJV IREB2 SLC11A2 SLC40A1 TFRC
7 mortality/aging MP:0010768 9.23 EPO HFE HJV IREB2 SLC11A2 SLC40A1

Drugs & Therapeutics for Iron Metabolism Disease

Search Clinical Trials , NIH Clinical Center for Iron Metabolism Disease

Cochrane evidence based reviews: iron metabolism disorders

Genetic Tests for Iron Metabolism Disease

Anatomical Context for Iron Metabolism Disease

MalaCards organs/tissues related to Iron Metabolism Disease:

41
Heart, Kidney, Testes, Lung, Brain, Liver, Bone

Publications for Iron Metabolism Disease

Articles related to Iron Metabolism Disease:

(show top 50) (show all 2326)
# Title Authors Year
1
Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia. ( 29795991 )
2018
2
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
3
Protein-Losing Enteropathy in the Setting of Severe Iron Deficiency Anemia. ( 29511696 )
2018
4
Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis. ( 29435325 )
2018
5
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma. ( 29955854 )
2018
6
Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood are Associated with Behavior Problems in Adolescent Boys: Results from the BogotA! School Children Cohort. ( 29897579 )
2018
7
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis. ( 29499633 )
2018
8
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs. ( 29772815 )
2018
9
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
10
A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review. ( 29851802 )
2018
11
Cooking in Iron Pots for Iron Deficiency Anemia: The Traditional Way Forward? ( 29948738 )
2018
12
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
13
Oral versus intravenous iron therapy in patients with inflammatory bowel disease and iron deficiency with and without anemia in Germany - a real-world evidence analysis. ( 29440920 )
2018
14
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
15
Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen. ( 29850236 )
2018
16
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
17
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
18
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
19
A comment on the comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia. ( 29981266 )
2018
20
Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia. ( 29868633 )
2018
21
Efficacy of ferrous bis-glycinate versus ferrous glycine sulfate in the treatment of iron deficiency anemia with pregnancy: a randomized double-blind clinical trial. ( 29843553 )
2018
22
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
23
Safety and Efficacy of Ferric Carboxymaltose in the Treatment of Iron Deficiency Anaemia in Patients with Inflammatory Bowel Disease, in Routine Daily Practice. ( 29955835 )
2018
24
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
25
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
26
The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia. ( 29928945 )
2018
27
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
28
Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis. ( 29767699 )
2018
29
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
30
Iron Deficiency Anemia with Menorrhagia: Ferric Carboxymaltose a Safer Alternative to Blood Transfusion. ( 29962808 )
2018
31
New Onset Iron Deficiency Anemia in Chronic Therapeutic Plasma Exchange Patients. ( 29970428 )
2018
32
Relation between Depressive Disorder and Iron Deficiency Anemia among Adults Reporting to a Secondary Healthcare Facility: A Hospital-Based Case Control Study. ( 29848423 )
2018
33
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial. ( 29917215 )
2018
34
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
35
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
36
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
37
Effects of an enhanced iron dense foods offering in the daily meals served in geriatric institutions on measures of iron deficiency anemia. ( 29801478 )
2018
38
Usefulness of Oral Ferric Citrate in Patients With Iron-Deficiency Anemia and Chronic Kidney Disease With or Without Heart Failure. ( 29961562 )
2018
39
A Toddler With Treatment-Resistant Iron Deficiency Anemia. ( 29950397 )
2018
40
Angular cheilitis induced by iron deficiency anemia. ( 30102595 )
2018
41
A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center. ( 29736076 )
2018
42
Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test. ( 30502855 )
2018
43
Should sex differences be considered when applying mathematical indices and formulas for discriminating β- thalassemia minor from iron deficiency? ( 30202778 )
2018
44
Iron deficiency and cyanotic breath-holding spells: The effectiveness of iron therapy. ( 30351985 )
2018
45
Anaemia and iron deficiency in relation to fatigue in cystic fibrosis. ( 30195412 )
2018
46
Intestinal DMT1 Is Essential for Optimal Assimilation of Dietary Copper in Male and Female Mice with Iron-Deficiency Anemia. ( 30137476 )
2018
47
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease. ( 30150549 )
2018
48
Unexplained iron deficiency anemia: does Helicobacter pylori have a role to play? ( 30151206 )
2018
49
Efficacy and safety of ferric carboxymaltose versus ferrous sulfate for iron deficiency anemia during pregnancy: subgroup analysis of Korean women. ( 30153811 )
2018
50
Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma. ( 30155291 )
2018

Variations for Iron Metabolism Disease

Expression for Iron Metabolism Disease

Search GEO for disease gene expression data for Iron Metabolism Disease.

Pathways for Iron Metabolism Disease

Pathways related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
2 12.18 CP IREB2 SLC11A2
3
Show member pathways
12.08 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
4 11.63 EPO TF TFRC
5
Show member pathways
11.59 CP SLC11A2 SLC40A1
6 11.44 CP EPO TF TFRC
7 11.27 CYBRD1 SLC11A2 SLC40A1 TF
8 11.18 EPO TF
9 11.01 EPO SLC11A2
10 10.96 CP SLC11A2 SLC40A1 TF TFRC
11 10.21 HFE HJV
12 10.18 IREB2 SLC11A2 SLC40A1 TF TFR2 TFRC

GO Terms for Iron Metabolism Disease

Cellular components related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 CP EPO HFE HJV TF TFRC
2 integral component of plasma membrane GO:0005887 9.89 HFE SLC11A2 SLC40A1 TFR2 TFRC
3 perinuclear region of cytoplasm GO:0048471 9.78 HFE SLC11A2 TF TFRC
4 cytoplasmic vesicle GO:0031410 9.77 HFE SLC11A2 TF TFR2 TFRC
5 cell surface GO:0009986 9.72 EPO HJV SLC11A2 TF TFRC
6 lysosomal membrane GO:0005765 9.7 CP CYBRD1 SLC11A2
7 endosome membrane GO:0010008 9.63 SLC11A2 TF TFRC
8 blood microparticle GO:0072562 9.58 CP TF TFRC
9 early endosome GO:0005769 9.56 HFE SLC11A2 TF TFRC
10 extracellular vesicle GO:1903561 9.55 SLC11A2 TFRC
11 brush border membrane GO:0031526 9.54 CYBRD1 SLC11A2
12 clathrin-coated vesicle membrane GO:0030665 9.51 TF TFRC
13 recycling endosome GO:0055037 9.46 HFE SLC11A2 TF TFRC
14 basal part of cell GO:0045178 9.13 HFE SLC11A2 TF
15 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC

Biological processes related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.89 CP HFE SLC11A2 SLC40A1 TF
2 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
3 acute-phase response GO:0006953 9.61 EPO HFE TFR2
4 multicellular organismal iron ion homeostasis GO:0060586 9.58 HFE SLC11A2 SLC40A1
5 response to iron ion GO:0010039 9.56 CYBRD1 HFE SLC11A2 TFR2
6 osteoclast differentiation GO:0030316 9.55 IREB2 TFRC
7 iron ion transport GO:0006826 9.55 IREB2 SLC11A2 SLC40A1 TF TFR2
8 positive regulation of receptor-mediated endocytosis GO:0048260 9.54 HFE TF
9 cellular response to iron ion GO:0071281 9.54 HFE TF TFR2
10 copper ion transport GO:0006825 9.52 CP SLC11A2
11 positive regulation of peptide hormone secretion GO:0090277 9.51 HFE TFR2
12 iron ion import GO:0097286 9.48 TFR2 TFRC
13 regulation of iron ion import GO:1900390 9.46 HFE TF
14 iron ion homeostasis GO:0055072 9.43 HFE HJV SLC11A2 SLC40A1 TF TFR2
15 cellular iron ion homeostasis GO:0006879 9.32 CP CYBRD1 HFE HJV IREB2 SLC11A2

Molecular functions related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 9.4 HFE TFR2
2 iron ion transmembrane transporter activity GO:0005381 9.37 SLC11A2 SLC40A1
3 ferrous iron transmembrane transporter activity GO:0015093 9.32 SLC11A2 SLC40A1
4 oxidoreductase activity, oxidizing metal ions GO:0016722 9.26 CP CYBRD1
5 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
6 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
7 transferrin receptor binding GO:1990459 8.8 HFE HJV TF

Sources for Iron Metabolism Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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