MCID: IRN002
MIFTS: 55

Iron Metabolism Disease

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Iron Metabolism Disease

Summaries for Iron Metabolism Disease

MedlinePlus : 43 Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes. Your body needs the right amount of iron. If you have too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods. Too much iron can damage your body. Taking too many iron supplements can cause iron poisoning. Some people have an inherited disease called hemochromatosis. It causes too much iron to build up in the body. Centers for Disease Control and Prevention

MalaCards based summary : Iron Metabolism Disease, also known as iron deficiency, is related to iron-refractory iron deficiency anemia and ancylostomiasis. An important gene associated with Iron Metabolism Disease is TF (Transferrin), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. The drugs Iron and Zinc have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Iron deficiency, or sideropaenia, is the state in which a body has not enough (or not qualitatively... more...

Related Diseases for Iron Metabolism Disease

Diseases related to Iron Metabolism Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.3 EPO HJV
2 ancylostomiasis 31.6 CP TF
3 microcytic anemia 30.7 EPO IREB2 SLC11A2 TF TFRC
4 iron deficiency anemia 30.4 EPO HFE HJV SLC11A2 SLC40A1 TF
5 thalassemia 30.3 EPO HFE TF TFRC
6 aceruloplasminemia 29.2 CP HFE HJV TF TFR2
7 beta-thalassemia 28.8 EPO HFE TF TFR2 TFRC
8 hemosiderosis 28.2 CP EPO HFE SLC11A2 SLC40A1 TF
9 deficiency anemia 26.6 CP EPO HFE HJV SLC11A2 SLC40A1
10 hemochromatosis, type 1 26.4 CP CYBRD1 HFE HJV IREB2 SLC11A2
11 plummer vinson syndrome 11.4
12 autoimmune atrophic gastritis 11.3
13 atrophic gastritis 11.2
14 gastric antral vascular ectasia 11.1
15 anemia, congenital dyserythropoietic, type iii 10.8
16 mucolipidosis iv 10.8
17 pulmonary arterio-veinous fistula 10.8
18 iron overload in africa 10.7 HFE TF
19 anemia, hypochromic microcytic, with iron overload 1 10.6
20 hyperferritinemia with or without cataract 10.6 HFE TF
21 angiomatous meningioma 10.5 TF TFRC
22 fetal erythroblastosis 10.3 EPO TFRC
23 pure red-cell aplasia 10.3 EPO TF
24 aging 10.3
25 porphyria cutanea tarda 10.3 HFE TF TFRC
26 hemochromatosis, type 3 10.2 HFE TFR2
27 inflammatory bowel disease 10.2
28 thrombocytosis 10.2
29 celiac disease 1 10.2
30 analbuminemia 10.1 EPO TF
31 gastritis 10.1
32 folic acid deficiency anemia 10.1 EPO TF TFRC
33 hemoglobin h disease 10.1 EPO TF TFRC
34 hemochromatosis, type 4 10.1 SLC40A1 TFR2
35 immune system disease 10.1 EPO TF TFRC
36 vitamin b12 deficiency 10.1 EPO TF
37 swayback 9.9 CP HFE
38 siderosis 9.8 HFE SLC40A1 TF TFRC
39 epileptic encephalopathy, early infantile, 36 9.8 CP TF
40 eales disease 9.8 CP TF
41 nutritional deficiency disease 9.7 EPO HJV TF TFRC
42 hemoglobinopathy 9.7 EPO TF
43 myelodysplastic syndrome 9.7 EPO HFE TF TFRC
44 wilson disease 9.7 CP HFE TF
45 hypochromic microcytic anemia 9.6 CP SLC11A2 TF
46 inherited metabolic disorder 9.6 HFE HJV TF TFR2
47 protein-energy malnutrition 9.5 CP TF
48 hfe-associated hereditary hemochromatosis 9.5 HFE HJV SLC11A2 TFR2
49 hemochromatosis type 2 9.4 HFE HJV SLC40A1 TFR2
50 liver disease 9.4 CP HFE TF

Comorbidity relations with Iron Metabolism Disease via Phenotypic Disease Network (PDN):


Deficiency Anemia Pulmonary Hemosiderosis

Graphical network of the top 20 diseases related to Iron Metabolism Disease:



Diseases related to Iron Metabolism Disease

Symptoms & Phenotypes for Iron Metabolism Disease

MGI Mouse Phenotypes related to Iron Metabolism Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 IREB2 CP SLC11A2 EPO SLC40A1 HFE
2 homeostasis/metabolism MP:0005376 10.06 CP CYBRD1 SLC11A2 EPO SLC40A1 HFE
3 cardiovascular system MP:0005385 10.01 IREB2 CP CYBRD1 SLC11A2 EPO SLC40A1
4 immune system MP:0005387 9.91 IREB2 CP SLC11A2 EPO SLC40A1 HFE
5 liver/biliary system MP:0005370 9.65 CYBRD1 SLC11A2 EPO SLC40A1 HFE HJV
6 integument MP:0010771 9.63 IREB2 SLC11A2 EPO SLC40A1 HJV TFRC
7 mortality/aging MP:0010768 9.23 IREB2 SLC11A2 EPO SLC40A1 HFE TF

Drugs & Therapeutics for Iron Metabolism Disease

Drugs for Iron Metabolism Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 266)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6 23925
2
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 7440-66-6 23994
3
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 44475014
4
Halofantrine Approved Phase 4 69756-53-2 37393
5
Copper Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-50-8 27099
6
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
7
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7782-49-2
8
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
9
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
10
Clarithromycin Approved Phase 4 81103-11-9 84029
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 11103-57-4, 68-26-8 445354
13
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 5785 54670067
14
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
15
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 68-19-9 44176380
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
18
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 13422-55-4
19
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 59-67-6 938
20
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 98-92-0 936
21
Pyridoxal Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 66-72-8 1050
22
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 65-23-6 1054
23
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 83-88-5 493570
24
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
25
Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 1,Not Applicable 1406-66-2 14986
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
27
Vitamin D3 Approved, Nutraceutical Phase 4,Not Applicable 67-97-0 6221 5280795
28
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 59-02-9 14985
29
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
30
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
31 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Ferric oxide, saccharated Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Hematinics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
36 Teferrol Phase 4,Phase 3,Not Applicable
37 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Ferrous fumarate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
40 Ferrous gluconate Phase 4,Phase 1,Not Applicable
41 Epoetin alfa Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113427-24-0
42 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 ferric gluconate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Hepcidins Phase 4,Phase 1,Phase 2,Not Applicable
45 Vitamin B 12 Phase 4,Phase 2,Phase 3,Not Applicable
46 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Blood Substitutes Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Dextrans Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Iron-Dextran Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 567)
# Name Status NCT ID Phase Drugs
1 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
2 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
3 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
4 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
5 Iron Deficiency In Pulmonary Hypertension Unknown status NCT01288651 Phase 4 Ferricarboxymaltose
6 Optimizing Iron Suppletion After Roux-en-Y Gastric Bypass Unknown status NCT02271997 Phase 4 Ferrous fumarate;Ferrous gluconate;Iron(III)carboxymaltose
7 Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance In Non Anemic Premenopausal Women With Low Ferritin Levels Unknown status NCT01374776 Phase 4 Double blind, randomized, placebo controlled inter
8 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
9 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
10 Iron Absorption Trial Unknown status NCT02228902 Phase 4 Ferrous fumarate;Ferrous gluconate
11 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
12 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Completed NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
13 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
14 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
15 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
16 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
17 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
18 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
19 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
20 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
21 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
22 Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
23 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
24 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
25 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
26 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
27 Iron Substitution in Blood Donors Completed NCT01519830 Phase 4 Iron carboxymaltose (Ferinject);Placebo
28 Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age Completed NCT01110356 Phase 4 Ferinject
29 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
30 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
31 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
32 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
33 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
34 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
35 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
36 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
37 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
38 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
39 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
40 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
41 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
42 Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study) Completed NCT01609387 Phase 4
43 Periodic Versus Continuous IV Iron Supplementation in HD Patients Completed NCT02787824 Phase 4 Iron Sucrose Supplement
44 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
45 Vitamin B12 Pregnancy Supplementation Completed NCT03522428 Phase 4
46 The Use of Liposomated Iron After Bariatric Surgery in Patients That Are Receiving Parentheral Therapy With Iron Completed NCT02390921 Phase 4 Fisiogen Ferro Forte;Venofer
47 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
48 Small Bowel Cleansing Prior to Video Capsule Endoscopy Examination Completed NCT00677794 Phase 4 Clear fluids;Picosalax;Polyethylene glycol
49 Prenatal Iron and Malaria Study Completed NCT01308112 Phase 4
50 Effect of Iron Therapy as an Adjunct to Epoetin Alfa in the Anemia of Cancer Chemotherapy Completed NCT00224068 Phase 4 Sodium ferric gluconate, ferrous sulfate, standard of care

Search NIH Clinical Center for Iron Metabolism Disease

Cochrane evidence based reviews: iron metabolism disorders

Genetic Tests for Iron Metabolism Disease

Anatomical Context for Iron Metabolism Disease

MalaCards organs/tissues related to Iron Metabolism Disease:

41
Kidney, Heart, Lung, Testes, Brain, Liver, Bone

Publications for Iron Metabolism Disease

Articles related to Iron Metabolism Disease:

(show top 50) (show all 1284)
# Title Authors Year
1
Gastrointestinal Lesions in African American Patients With Iron Deficiency Anemia. ( 29795991 )
2018
2
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
3
Protein-Losing Enteropathy in the Setting of Severe Iron Deficiency Anemia. ( 29511696 )
2018
4
Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis. ( 29435325 )
2018
5
Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma. ( 29955854 )
2018
6
Iron Deficiency, Anemia, and Low Vitamin B-12 Serostatus in Middle Childhood are Associated with Behavior Problems in Adolescent Boys: Results from the BogotA! School Children Cohort. ( 29897579 )
2018
7
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis. ( 29499633 )
2018
8
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs. ( 29772815 )
2018
9
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
10
A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review. ( 29851802 )
2018
11
Cooking in Iron Pots for Iron Deficiency Anemia: The Traditional Way Forward? ( 29948738 )
2018
12
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
13
Oral versus intravenous iron therapy in patients with inflammatory bowel disease and iron deficiency with and without anemia in Germany - a real-world evidence analysis. ( 29440920 )
2018
14
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
15
Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen. ( 29850236 )
2018
16
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
17
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
18
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
19
A comment on the comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia. ( 29981266 )
2018
20
Diagnostic yield and predictive factors of findings in small-bowel capsule endoscopy in the setting of iron-deficiency anemia. ( 29868633 )
2018
21
Efficacy of ferrous bis-glycinate versus ferrous glycine sulfate in the treatment of iron deficiency anemia with pregnancy: a randomized double-blind clinical trial. ( 29843553 )
2018
22
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
23
Safety and Efficacy of Ferric Carboxymaltose in the Treatment of Iron Deficiency Anaemia in Patients with Inflammatory Bowel Disease, in Routine Daily Practice. ( 29955835 )
2018
24
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
25
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
26
The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia. ( 29928945 )
2018
27
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
28
Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis. ( 29767699 )
2018
29
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
30
Iron Deficiency Anemia with Menorrhagia: Ferric Carboxymaltose a Safer Alternative to Blood Transfusion. ( 29962808 )
2018
31
New Onset Iron Deficiency Anemia in Chronic Therapeutic Plasma Exchange Patients. ( 29970428 )
2018
32
Relation between Depressive Disorder and Iron Deficiency Anemia among Adults Reporting to a Secondary Healthcare Facility: A Hospital-Based Case Control Study. ( 29848423 )
2018
33
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial. ( 29917215 )
2018
34
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
35
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
36
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
37
Effects of an enhanced iron dense foods offering in the daily meals served in geriatric institutions on measures of iron deficiency anemia. ( 29801478 )
2018
38
Usefulness of Oral Ferric Citrate in Patients With Iron-Deficiency Anemia and Chronic Kidney Disease With or Without Heart Failure. ( 29961562 )
2018
39
A Toddler With Treatment-Resistant Iron Deficiency Anemia. ( 29950397 )
2018
40
Effect of dietary intervention treatment on children with iron deficiency anemia in China: a meta-analysis. ( 29747646 )
2018
41
Correction to: Carvalho et al., Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease. ( 28853335 )
2017
42
Reply: Intravenous Ferumoxytol in Pediatric Patients With Iron-Deficiency Anemia. ( 28831808 )
2017
43
Cerebral Venous Thrombosis in a Patient with Iron Deficiency Anemia and Thrombocytopenia: A Case Report. ( 29362628 )
2017
44
A new red cell index and portable RBC analyzer for screening of iron deficiency and Thalassemia minor in a Chinese population. ( 28874768 )
2017
45
VON WILLEBRAND FACTOR IMMUNOHISTOCHEMICAL STAINING QUANTITATIVE OPTICAL DENSITY PARAMETERS IN THE ENDOTHELIUM AND FIBRINOID OF THE PLACENTA DURING SECUNDINES INFLAMMATION AND CONCOMITANT IRON DEFICIENCY ANEMIA IN GRAVIDAS. ( 29328041 )
2017
46
Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia. ( 29282766 )
2017
47
Comparison of Methods Study between a Photonic Crystal Biosensor and Certified ELISA to Measure Biomarkers of Iron Deficiency in Chronic Kidney Disease Patients. ( 28946680 )
2017
48
The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease. ( 29023457 )
2017
49
Phase III randomized trial comparing intravenous to oral iron in patients with cancer-related iron deficiency anemia not on erythropoiesis stimulating agents. ( 28849623 )
2017
50
Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. ( 28460265 )
2017

Variations for Iron Metabolism Disease

Expression for Iron Metabolism Disease

Search GEO for disease gene expression data for Iron Metabolism Disease.

Pathways for Iron Metabolism Disease

Pathways related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
2
Show member pathways
12.08 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
3 11.63 EPO TF TFRC
4
Show member pathways
11.59 CP SLC11A2 SLC40A1
5 11.44 CP EPO TF TFRC
6 11.27 CYBRD1 SLC11A2 SLC40A1 TF
7 11.18 EPO TF
8 11.01 EPO SLC11A2
9 10.96 CP SLC11A2 SLC40A1 TF TFRC
10 10.21 HFE HJV
11 10.18 IREB2 SLC11A2 SLC40A1 TF TFR2 TFRC

GO Terms for Iron Metabolism Disease

Cellular components related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 HFE SLC11A2 SLC40A1 TFR2 TFRC
2 extracellular space GO:0005615 9.88 CP EPO HFE HJV TF TFRC
3 perinuclear region of cytoplasm GO:0048471 9.78 HFE SLC11A2 TF TFRC
4 cytoplasmic vesicle GO:0031410 9.77 HFE SLC11A2 TF TFR2 TFRC
5 lysosomal membrane GO:0005765 9.73 CP CYBRD1 SLC11A2
6 cell surface GO:0009986 9.72 EPO HJV SLC11A2 TF TFRC
7 external side of plasma membrane GO:0009897 9.69 HFE TFR2 TFRC
8 endosome membrane GO:0010008 9.63 SLC11A2 TF TFRC
9 blood microparticle GO:0072562 9.61 CP TF TFRC
10 early endosome GO:0005769 9.56 HFE SLC11A2 TF TFRC
11 brush border membrane GO:0031526 9.54 CYBRD1 SLC11A2
12 extracellular vesicle GO:1903561 9.52 SLC11A2 TFRC
13 clathrin-coated vesicle membrane GO:0030665 9.49 TF TFRC
14 recycling endosome GO:0055037 9.46 HFE SLC11A2 TF TFRC
15 basal part of cell GO:0045178 9.13 HFE SLC11A2 TF
16 HFE-transferrin receptor complex GO:1990712 9.02 HFE HJV TF TFR2 TFRC

Biological processes related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.89 CP HFE SLC11A2 SLC40A1 TF
2 cellular iron ion homeostasis GO:0006879 9.65 CP CYBRD1 HFE HJV IREB2 SLC11A2
3 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
4 acute-phase response GO:0006953 9.61 EPO HFE TFR2
5 multicellular organismal iron ion homeostasis GO:0060586 9.58 HFE SLC11A2 SLC40A1
6 response to iron ion GO:0010039 9.56 CYBRD1 HFE SLC11A2 TFR2
7 osteoclast differentiation GO:0030316 9.55 IREB2 TFRC
8 iron ion transport GO:0006826 9.55 IREB2 SLC11A2 SLC40A1 TF TFR2
9 positive regulation of receptor-mediated endocytosis GO:0048260 9.54 HFE TF
10 cellular response to iron ion GO:0071281 9.54 HFE TF TFR2
11 copper ion transport GO:0006825 9.52 CP SLC11A2
12 positive regulation of peptide hormone secretion GO:0090277 9.51 HFE TFR2
13 iron ion import GO:0097286 9.48 TFR2 TFRC
14 regulation of iron ion import GO:1900390 9.46 HFE TF
15 iron ion homeostasis GO:0055072 9.17 HFE HJV IREB2 SLC11A2 SLC40A1 TF

Molecular functions related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 9.37 HFE TFR2
2 iron ion transmembrane transporter activity GO:0005381 9.32 SLC11A2 SLC40A1
3 ferrous iron transmembrane transporter activity GO:0015093 9.26 SLC11A2 SLC40A1
4 transferrin receptor activity GO:0004998 9.16 TFR2 TFRC
5 transferrin transmembrane transporter activity GO:0033570 8.96 TFR2 TFRC
6 transferrin receptor binding GO:1990459 8.8 HFE HJV TF

Sources for Iron Metabolism Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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