MCID: IRN008
MIFTS: 42

Iron Overload in Africa

Categories: Gastrointestinal diseases, Immune diseases, Liver diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Iron Overload in Africa

MalaCards integrated aliases for Iron Overload in Africa:

Name: Iron Overload in Africa 58 12 54
African Iron Overload 58 12 54 26 60 56 15
Bantu Siderosis 58 12 77 54 60 74
African Hemochromatosis 26 74
Hereditary Iron Overload and African Americans 54
African Nutritional Hemochromatosis 26
African Siderosis 26

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant plus dietary factor


Classifications:



External Ids:

Disease Ontology 12 DOID:0111033
OMIM 58 601195
ICD10 34 E83.1
ICD10 via Orphanet 35 E83.1
UMLS via Orphanet 75 C0268063
Orphanet 60 ORPHA139507
MedGen 43 C0268063

Summaries for Iron Overload in Africa

OMIM : 58 African iron overload is a distinct iron-loading disorder prevalent in Africa. Formerly termed Bantu siderosis, the disorder results from a predisposition to iron loading that is exacerbated by excessive intake of dietary iron. It is particularly a problem among Africans who drink a traditional beer brewed in non-galvanized steel drums. Although the disorder was once attributed to dietary excess alone, serious iron overload does not develop in all beer drinkers, and not all patients with iron overload consume excessive amounts of the beer (summary by Andrews, 1999). (601195)

MalaCards based summary : Iron Overload in Africa, also known as african iron overload, is related to siderosis and hemosiderosis. An important gene associated with Iron Overload in Africa is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Insulin receptor recycling and Metal ion SLC transporters. Affiliated tissues include liver, bone and spleen, and related phenotypes are abnormality of metabolism/homeostasis and elevated transferrin saturation

Disease Ontology : 12 A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums.

Genetics Home Reference : 26 African iron overload is a condition that involves absorption of too much iron from the diet. The excess iron is stored in the body's tissues and organs, particularly the liver, bone marrow, and spleen. Humans cannot increase the excretion of iron, although some iron is lost through bleeding or when cells of the intestine (enterocytes) are shed at the end of the cells' lifespan. Iron levels in the body are primarily regulated through control of how much iron is absorbed from the diet.

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 139507Disease definitionAfrican iron overload is a rare disorder described in sub-Saharan African populations and is characterized by iron overload due to excess dietary iron intake and possibly genetic factors, leading to hepatic portal fibrosis and micronodular cirrhosis.Visit the Orphanet disease page for more resources.

Wikipedia : 77 African iron overload, also known as (Bantu siderosis, or Dietary iron overload), is an iron overload... more...

Related Diseases for Iron Overload in Africa

Diseases related to Iron Overload in Africa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 siderosis 30.7 HFE SLC40A1 TF TFRC
2 hemosiderosis 29.8 HAMP HFE SLC40A1 TF TFRC
3 hyperferritinemia with or without cataract 10.3 HFE TF
4 folic acid deficiency anemia 10.2 TF TFRC
5 chondrocalcinosis 10.2 CASR HFE
6 angiomatous meningioma 10.2 TF TFRC
7 progressive bulbar palsy 10.2 HLA-A TF
8 histoplasmosis 10.2 HLA-A TF
9 pure red-cell aplasia 10.1 HLA-A TF
10 chronic inflammatory demyelinating polyneuropathy 10.1 HP TF
11 extrapulmonary tuberculosis 10.1 HAMP SLC11A1
12 nontuberculous mycobacterial lung disease 10.1 HLA-A SLC11A1
13 melancholia 10.1 HP TF
14 rhizomelic chondrodysplasia punctata, type 2 10.1 HAMP HFE
15 congenital disorder of glycosylation, type ia 10.1 HP TF
16 thalassemia 10.1 HFE TF TFRC
17 dysentery 10.1 HP TF
18 hepatitis 10.0
19 hepatitis b 10.0
20 peritonitis 10.0
21 protein-energy malnutrition 10.0 HP TF
22 anemia, sideroblastic, 1 10.0 HAMP TFRC
23 hepatocellular carcinoma 9.9
24 inherited metabolic disorder 9.9 HAMP HFE TF TFR2
25 testicular yolk sac tumor 9.9 HP TF
26 celiac disease 1 9.9 HFE HLA-A TFRC
27 beta-thalassemia 9.9 HFE TF TFR2 TFRC
28 hemochromatosis, type 3 9.9 HAMP HFE SLC40A1 TFR2
29 fructose intolerance, hereditary 9.9 HP TF
30 hemoglobin h disease 9.9 TF TFRC
31 porphyria cutanea tarda 9.9 HAMP HFE TF TFRC
32 hemochromatosis, type 4 9.8 HAMP HFE SLC40A1 TF TFR2
33 hemochromatosis type 2 9.8 HAMP HFE SLC40A1 TF TFR2
34 hemoglobinopathy 9.8 HAMP HFE HP TF
35 iron metabolism disease 9.7 HFE SLC40A1 TF TFR2 TFRC
36 aceruloplasminemia 9.7 HAMP HEPH HFE TF TFR2
37 iron deficiency anemia 9.5 HAMP HFE SLC40A1 TF TFR2 TFRC
38 malaria 9.3 HAMP HLA-A HP TF TFRC
39 metal metabolism disorder 9.3 CASR HAMP HFE SLC40A1 TF TFR2
40 atransferrinemia 8.8 HAMP HEPH HFE HP SLC40A1 TF
41 deficiency anemia 8.8 HAMP HEPH HFE HP SLC40A1 TF
42 hemochromatosis, type 1 8.6 CASR HAMP HEPH HFE HP SLC40A1

Graphical network of the top 20 diseases related to Iron Overload in Africa:



Diseases related to Iron Overload in Africa

Symptoms & Phenotypes for Iron Overload in Africa

Human phenotypes related to Iron Overload in Africa:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 33 HP:0001939
2 elevated transferrin saturation 33 HP:0012463

Symptoms via clinical synopsis from OMIM:

58
Lab:
elevated transferrin saturation

Misc:
increased dietary iron

Clinical features from OMIM:

601195

MGI Mouse Phenotypes related to Iron Overload in Africa:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CASR HEPH HFE HP SLC11A1 SLC40A1
2 digestive/alimentary MP:0005381 9.73 CASR HEPH HFE SLC11A1 SLC40A1 TFRC
3 immune system MP:0005387 9.56 CASR HEPH HFE HP SLC11A1 SLC40A1
4 liver/biliary system MP:0005370 9.1 HEPH HFE HP SLC40A1 TFR2 TFRC

Drugs & Therapeutics for Iron Overload in Africa

Search Clinical Trials , NIH Clinical Center for Iron Overload in Africa

Genetic Tests for Iron Overload in Africa

Anatomical Context for Iron Overload in Africa

MalaCards organs/tissues related to Iron Overload in Africa:

42
Liver, Bone, Spleen, Bone Marrow

Publications for Iron Overload in Africa

Articles related to Iron Overload in Africa:

(show all 12)
# Title Authors Year
1
Type 3 hereditary hemochromatosis in a patient from sub-Saharan Africa: is there a link between African iron overload and TFR2 dysfunction? ( 22981443 )
2013
2
African iron overload. ( 12382201 )
2002
3
African iron overload. ( 10881373 )
2000
4
Measurements of iron status and survival in African iron overload. ( 10554633 )
1999
5
Evidence of genetic transmission in African iron overload. ( 9446671 )
1998
6
African iron overload and hepatocellular carcinoma (HA-7-0-080). ( 9451425 )
1998
7
Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene? ( 9753041 )
1998
8
Tuberculosis and iron overload in Africa: a review. ( 9631102 )
1997
9
Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited. ( 8605366 )
1996
10
Hepatocellular carcinoma and african iron overload. ( 8984039 )
1996
11
Hepatocellular carcinoma and African iron overload. ( 8549953 )
1995
12
Iron overload in Africa. Interaction between a gene and dietary iron content. ( 1727237 )
1992

Variations for Iron Overload in Africa

Expression for Iron Overload in Africa

Search GEO for disease gene expression data for Iron Overload in Africa.

Pathways for Iron Overload in Africa

GO Terms for Iron Overload in Africa

Cellular components related to Iron Overload in Africa according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.93 HAMP HEPH HFE HP TF TFRC
2 cell surface GO:0009986 9.8 CASR HLA-A TF TFRC
3 endosome membrane GO:0010008 9.65 SLC11A1 TF TFRC
4 blood microparticle GO:0072562 9.58 HP TF TFRC
5 recycling endosome GO:0055037 9.54 HFE TF TFRC
6 integral component of plasma membrane GO:0005887 9.5 CASR HFE HLA-A SLC11A1 SLC40A1 TFR2
7 basolateral plasma membrane GO:0016323 9.46 CASR HEPH SLC40A1 TFRC
8 basal part of cell GO:0045178 9.32 HFE TF
9 MHC class I protein complex GO:0042612 9.26 HFE HLA-A
10 HFE-transferrin receptor complex GO:1990712 8.92 HFE TF TFR2 TFRC
11 plasma membrane GO:0005886 10.09 CASR HEPH HFE HLA-A SLC11A1 SLC40A1

Biological processes related to Iron Overload in Africa according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.89 HEPH HFE SLC11A1 SLC40A1 TF
2 immune response GO:0006955 9.83 HAMP HFE HLA-A SLC11A1
3 defense response to bacterium GO:0042742 9.75 HAMP HP SLC11A1
4 receptor-mediated endocytosis GO:0006898 9.72 HP TFR2 TFRC
5 acute-phase response GO:0006953 9.67 HAMP HFE HP TFR2
6 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
7 response to iron ion GO:0010039 9.61 HAMP HFE TFR2
8 cellular response to iron ion GO:0071281 9.58 HFE TF TFR2
9 antigen processing and presentation GO:0019882 9.57 HFE HLA-A
10 liver regeneration GO:0097421 9.56 HAMP HFE
11 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A1 SLC40A1
12 iron ion transport GO:0006826 9.55 HEPH SLC11A1 SLC40A1 TF TFR2
13 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.54 HFE HLA-A
14 positive regulation of receptor-mediated endocytosis GO:0048260 9.51 HFE TF
15 positive regulation of peptide hormone secretion GO:0090277 9.48 HFE TFR2
16 response to iron ion starvation GO:1990641 9.46 HAMP HFE
17 iron ion homeostasis GO:0055072 9.43 HEPH HFE SLC11A1 SLC40A1 TF TFR2
18 cellular iron ion homeostasis GO:0006879 9.23 HAMP HEPH HFE SLC11A1 SLC40A1 TF

Molecular functions related to Iron Overload in Africa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.4 HFE HLA-A
2 ferrous iron binding GO:0008198 9.37 HEPH TF
3 co-receptor binding GO:0039706 9.32 HFE TFR2
4 transferrin receptor binding GO:1990459 9.26 HFE TF
5 beta-2-microglobulin binding GO:0030881 9.16 HFE HLA-A
6 transferrin receptor activity GO:0004998 8.96 TFR2 TFRC
7 transferrin transmembrane transporter activity GO:0033570 8.62 TFR2 TFRC

Sources for Iron Overload in Africa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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