MCID: IRN008
MIFTS: 50

Iron Overload in Africa

Categories: Cancer diseases, Gastrointestinal diseases, Immune diseases, Liver diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Iron Overload in Africa

MalaCards integrated aliases for Iron Overload in Africa:

Name: Iron Overload in Africa 57 12 20
African Iron Overload 57 12 20 43 58 54 15
Bantu Siderosis 57 12 73 20 58 70
African Hemochromatosis 43 70
Hereditary Iron Overload and African Americans 20
African Nutritional Hemochromatosis 43
African Siderosis 43

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant plus dietary factor


HPO:

31
iron overload in africa:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare hepatic diseases
Inborn errors of metabolism


External Ids:

Disease Ontology 12 DOID:0111033
OMIM® 57 601195
ICD10 32 E83.1
ICD10 via Orphanet 33 E83.1
UMLS via Orphanet 71 C0268063
Orphanet 58 ORPHA139507
MedGen 41 C0268063
UMLS 70 C0268063 C3711388

Summaries for Iron Overload in Africa

MedlinePlus Genetics : 43 African iron overload is a condition that involves absorption of too much iron from the diet. The excess iron is stored in the body's tissues and organs, particularly the liver, bone marrow, and spleen. Humans cannot increase the excretion of iron, although some iron is lost through bleeding or when cells of the intestine (enterocytes) are shed at the end of the cells' lifespan. Iron levels in the body are primarily regulated through control of how much iron is absorbed from the diet.African iron overload results from a diet high in iron. It is particularly associated with consumption of a traditional African beer that contains dissolved iron from the metal drums in which it is brewed. Some evidence suggests that a genetic predisposition to absorbing too much iron may also be involved.In African iron overload, excess iron typically accumulates primarily in certain immune cells called reticuloendothelial cells. Reticuloendothelial cells include macrophages in the bone marrow and spleen and Kupffer cells, which are specialized macrophages found in the liver that help protect the body against foreign invaders such as viruses and bacteria. Later in the course of the condition, iron also accumulates in liver cells (hepatocytes). This pattern differs from that seen in a similar iron overload disorder called hereditary hemochromatosis, in which the excess iron accumulates primarily in the hepatocytes.When too much iron is absorbed, the resulting iron overload can eventually damage tissues and organs. Iron overload in the liver can lead to chronic liver disease (cirrhosis). Cirrhosis increases the risk of developing a type of liver cancer called hepatocellular carcinoma. Iron overload in immune cells may affect their ability to fight infections. African iron overload is associated with an increased risk of developing infections such as tuberculosis. The excess iron also leads to a faster-than-normal breakdown of vitamin C in the body, so affected individuals are at increased risk of vitamin C deficiency problems such as scurvy.People with African iron overload may have a slightly low number of red blood cells (mild anemia), possibly because the iron that accumulates in the liver, bone marrow, and spleen is less available for production of red blood cells. Affected individuals also have high levels of a protein called ferritin in their blood, which can be detected with a blood test. Ferritin stores and releases iron in cells, and cells produce more ferritin in response to excess amounts of iron.

MalaCards based summary : Iron Overload in Africa, also known as african iron overload, is related to siderosis and rare hereditary hemochromatosis. An important gene associated with Iron Overload in Africa is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Insulin receptor recycling and Mineral absorption. Affiliated tissues include liver, bone marrow and spleen, and related phenotypes are increased circulating ferritin concentration and elevated hepatic iron concentration

Disease Ontology : 12 A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums.

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 139507 Definition A rare disorder described in sub-Saharan African populations and characterized by iron overload due to excess dietary iron intake and possibly genetic factors, leading to hepatic portal fibrosis and micronodular cirrhosis.

OMIM® : 57 African iron overload is a distinct iron-loading disorder prevalent in Africa. Formerly termed Bantu siderosis, the disorder results from a predisposition to iron loading that is exacerbated by excessive intake of dietary iron. It is particularly a problem among Africans who drink a traditional beer brewed in non-galvanized steel drums. Although the disorder was once attributed to dietary excess alone, serious iron overload does not develop in all beer drinkers, and not all patients with iron overload consume excessive amounts of the beer (summary by Andrews, 1999). (601195) (Updated 20-May-2021)

Wikipedia : 73 African iron overload, also known as (Bantu siderosis, or Dietary iron overload), is an iron overload... more...

Related Diseases for Iron Overload in Africa

Diseases related to Iron Overload in Africa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 siderosis 29.5 TF SLC40A1 HFE HAMP
2 rare hereditary hemochromatosis 29.3 TFR2 TF SLC40A1 HJV HFE HAMP
3 hemosiderosis 29.3 TFR2 TF SLC40A1 HJV HFE HAMP
4 hemochromatosis, type 1 28.4 TFR2 TF SLC40A1 HJV HFE HEPH
5 hepatocellular carcinoma 10.0
6 mycobacterium tuberculosis 1 10.0
7 acquired immunodeficiency syndrome 10.0
8 cutaneous porphyria 10.0 HFE HAMP
9 mitochondrial dna depletion syndrome 3 10.0 SLC40A1 HJV
10 hypoascorbemia 10.0
11 viral hepatitis 10.0
12 liver cirrhosis 10.0
13 peritonitis 10.0
14 tfr2-related hereditary hemochromatosis 10.0
15 mineral metabolism disease 10.0 HFE HAMP
16 hemochromatosis, type 2a 10.0 HJV HAMP
17 congenital dyserythropoietic anemia 10.0 HFE HAMP
18 hemoglobin h disease 9.9 TF HAMP
19 anemia, congenital dyserythropoietic, type ia 9.9 HJV HAMP
20 hemochromatosis, type 5 9.9 TFR2 HJV HFE
21 alpha-1-antitrypsin deficiency 9.9 HFE HAMP
22 hypochromic microcytic anemia 9.8 TF HJV HAMP
23 nutritional deficiency disease 9.8 TF HJV HAMP
24 sideroblastic anemia 9.8 TFR2 SLC40A1 HAMP
25 arthropathy 9.8 HJV HFE HAMP
26 congenital hemolytic anemia 9.7 TF HAMP
27 liver disease 9.7 TF SLC40A1 HFE
28 inherited metabolic disorder 9.6 TFR2 HJV HFE HAMP
29 anemia, sideroblastic, 1 9.6 TFR2 SLC40A1 HJV HAMP
30 hemoglobinopathy 9.5 TFR2 TF HJV HFE HAMP
31 beta-thalassemia 9.4 TFR2 TF HJV HFE HAMP
32 hemochromatosis, type 3 9.4 TFR2 SLC40A1 HJV HFE HAMP
33 porphyria 9.4 TFR2 SLC40A1 HJV HFE HAMP
34 neurodegeneration with brain iron accumulation 9.3 TFR2 SLC40A1 HFE HEPH HAMP
35 hyperferritinemia with or without cataract 9.3 TFR2 TF SLC40A1 HJV HFE HAMP
36 porphyria cutanea tarda 9.2 TFR2 TF SLC40A1 HJV HFE HAMP
37 hemochromatosis, type 4 9.1 TFR2 SLC40A1 HJV HFE HEPH HAMP
38 microcytic anemia 9.1 TFR2 TF SLC40A1 HJV HEPH HAMP
39 hemochromatosis type 2 9.1 TFR2 SLC40A1 HJV HFE HEPH HAMP
40 metal metabolism disorder 9.1 TFR2 SLC40A1 HJV HFE HEPH HAMP
41 aceruloplasminemia 9.1 TFR2 SLC40A1 HJV HFE HEPH HAMP
42 iron metabolism disease 8.9 TFR2 TF SLC40A1 HJV HFE HEPH
43 iron deficiency anemia 8.9 TFR2 TF SLC40A1 HJV HFE HEPH
44 deficiency anemia 8.9 TFR2 TF SLC40A1 HJV HFE HEPH
45 atransferrinemia 8.9 TFR2 TF SLC40A1 HJV HFE HEPH

Graphical network of the top 20 diseases related to Iron Overload in Africa:



Diseases related to Iron Overload in Africa

Symptoms & Phenotypes for Iron Overload in Africa

Human phenotypes related to Iron Overload in Africa:

31 58 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 increased circulating ferritin concentration 31 hallmark (90%) HP:0003281
2 elevated hepatic iron concentration 58 31 frequent (33%) Frequent (79-30%) HP:0012465
3 elevated transferrin saturation 58 31 frequent (33%) Frequent (79-30%) HP:0012463
4 viral hepatitis 58 31 frequent (33%) Frequent (79-30%) HP:0006562
5 hepatic periportal necrosis 58 31 frequent (33%) Frequent (79-30%) HP:0002614
6 diabetes mellitus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000819
7 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
8 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
9 hepatic steatosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001397
10 abnormality of the genital system 58 31 occasional (7.5%) Occasional (29-5%) HP:0000078
11 abnormal pancreas morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012090
12 abnormal heart morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001627
13 hepatocellular carcinoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001402
14 chronic infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0031035
15 increased circulating cortisol level 58 31 occasional (7.5%) Occasional (29-5%) HP:0003118
16 micronodular cirrhosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001413
17 abnormality of adrenal morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0011732
18 hepatic bridging fibrosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012852
19 abnormal thyroid morphology 31 occasional (7.5%) HP:0011772
20 low levels of vitamin c 31 occasional (7.5%) HP:0100510
21 osteoporosis 58 31 very rare (1%) Very rare (<4-1%) HP:0000939
22 peritonitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002586
23 esophageal carcinoma 58 31 very rare (1%) Very rare (<4-1%) HP:0011459
24 hepatitis 58 Frequent (79-30%)
25 hepatic fibrosis 58 Frequent (79-30%)
26 abnormality of metabolism/homeostasis 31 HP:0001939
27 increased serum ferritin 58 Very frequent (99-80%)
28 abnormality of thyroid morphology 58 Occasional (29-5%)
29 vitamin c deficiency 58 Occasional (29-5%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Lab:
elevated transferrin saturation

Misc:
increased dietary iron

Clinical features from OMIM®:

601195 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Iron Overload in Africa:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.02 HEPH HFE HJV SLC40A1 TFR2

Drugs & Therapeutics for Iron Overload in Africa

Search Clinical Trials , NIH Clinical Center for Iron Overload in Africa

Genetic Tests for Iron Overload in Africa

Anatomical Context for Iron Overload in Africa

MalaCards organs/tissues related to Iron Overload in Africa:

40
Liver, Bone Marrow, Spleen, Bone, Heart, Pancreas, Thyroid

Publications for Iron Overload in Africa

Articles related to Iron Overload in Africa:

(show all 32)
# Title Authors PMID Year
1
Iron overload in Africa. Interaction between a gene and dietary iron content. 57 54 61
1727237 1992
2
Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene? 57 61
9753041 1998
3
Evidence of genetic transmission in African iron overload. 57 61
9446671 1998
4
Tuberculosis and iron overload in Africa: a review. 57 61
9631102 1997
5
Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited. 57 61
8605366 1996
6
Disorders of iron metabolism. 57
10607817 1999
7
Iron overload in urban Africans in the 1990s. 57
10403742 1999
8
Mutation analysis of the HFE gene associated with hereditary hemochromatosis in African Americans. 57
9662273 1998
9
Global prevalence of putative haemochromatosis mutations. 57
9138148 1997
10
Primary iron overload in African Americans. 57
8686721 1996
11
Hereditary iron overload and African Americans. 57
8686715 1996
12
Iron overload in African Americans. 57
7503084 1995
13
Chelation therapy for iron overload. 54 61
17335681 2007
14
Basal endocrine status in African dietary iron overload. 54 61
14515008 2003
15
African iron overload. 54 61
12382201 2002
16
Clinical and genetic heterogeneity in hereditary haemochromatosis: association between lymphocyte counts and expression of iron overload. 54 61
11722599 2001
17
Transferrin polymorphism influences iron status in blacks. 61 54
11017929 2000
18
Type 3 hereditary hemochromatosis in a patient from sub-Saharan Africa: is there a link between African iron overload and TFR2 dysfunction? 61
22981443 2013
19
The effect of the host's iron status on tuberculosis. 61
17492589 2007
20
Ferroportin (Q248H) mutations in African families with dietary iron overload. 61
16336444 2005
21
Iron, hemochromatosis, and hepatocellular carcinoma. 61
15508107 2004
22
Iron deficiency and overload. 61
14633776 2003
23
HFE mutations in African-American women with non-insulin-dependent diabetes mellitus. 61
11763282 2001
24
African iron overload. 61
10881373 2000
25
[Iron overload and cancer]. 54
10989544 2000
26
Measurements of iron status and survival in African iron overload. 61
10554633 1999
27
Molecular insights into mechanisms of iron transport. 61
10088633 1999
28
African iron overload and hepatocellular carcinoma (HA-7-0-080). 61
9451425 1998
29
Hepatocellular carcinoma and african iron overload. 61
8984039 1996
30
Hepatocellular carcinoma and African iron overload. 61
8549953 1995
31
Dissociation between tissue iron concentrations and transferrin saturation among inbred mouse strains. 61
7636385 1995
32
HLA-linked hemochromatosis and other forms of iron overload. 61
7712651 1995

Variations for Iron Overload in Africa

Cosmic variations for Iron Overload in Africa:

9 (show top 50) (show all 15388)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM97724722 ZXDB liver,NS,carcinoma,hepatocellular carcinoma c.1308C>A p.D436E 23:57593356-57593356 3
2 COSM94430614 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
3 COSM94436083 ZSWIM1 liver,NS,carcinoma,hepatocellular carcinoma c.1399A>C p.S467R 20:45883991-45883991 3
4 COSM94063771 ZSCAN20 liver,NS,carcinoma,hepatocellular carcinoma c.2314G>T p.G772W 1:33494658-33494658 3
5 COSM88264637 ZRSR2 liver,NS,carcinoma,hepatocellular carcinoma c.304G>T p.E102* 23:15803788-15803788 3
6 COSM102741209 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.859A>G p.M287V 22:29049340-29049340 3
7 COSM131494492 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.1159A>G p.M387V 22:29049340-29049340 3
8 COSM103081572 ZNRF3 liver,NS,carcinoma,hepatocellular carcinoma c.859A>G p.M287V 22:29049340-29049340 3
9 COSM95977701 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
10 COSM102131817 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
11 COSM95960776 ZNFX1 liver,NS,carcinoma,hepatocellular carcinoma c.2580G>A p.L860= 20:49257501-49257501 3
12 COSM113317148 ZNF853 liver,NS,carcinoma,hepatocellular carcinoma c.1610G>T p.G537V 7:6622601-6622601 3
13 COSM99592496 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.829T>A p.F277I 19:36891962-36891962 3
14 COSM128686611 ZNF829 liver,NS,carcinoma,hepatocellular carcinoma c.1072T>A p.F358I 19:36891962-36891962 3
15 COSM123358576 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.691C>T p.L231= 4:145885684-145885684 3
16 COSM123949383 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581= 4:145885684-145885684 3
17 COSM101741672 ZNF827 liver,NS,carcinoma,hepatocellular carcinoma c.1741C>T p.L581= 4:145885684-145885684 3
18 COSM86004822 ZNF653 liver,NS,carcinoma,hepatocellular carcinoma c.1553A>C p.H518P 19:11485673-11485673 3
19 COSM98561269 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
20 COSM142353152 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
21 COSM142221290 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
22 COSM99854658 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.156G>A p.V52= 19:52002156-52002156 3
23 COSM139729931 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
24 COSM141470046 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
25 COSM141819438 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
26 COSM145038099 ZNF615 liver,NS,carcinoma,hepatocellular carcinoma c.141G>A p.V47= 19:52002156-52002156 3
27 COSM91868668 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.3900G>T p.K1300N 19:30557161-30557161 3
28 COSM91880764 ZNF536 liver,NS,carcinoma,hepatocellular carcinoma c.2171-78T>G p.? 19:30534769-30534769 3
29 COSM140721836 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.2998+205G>A p.? 18:25194955-25194955 3
30 COSM131506983 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.3658+205G>A p.? 18:25194955-25194955 3
31 COSM94799980 ZNF521 liver,NS,carcinoma,hepatocellular carcinoma c.3658+205G>A p.? 18:25194955-25194955 3
32 COSM90582798 ZNF518B liver,NS,carcinoma,hepatocellular carcinoma c.1624G>T p.E542* 4:10444705-10444705 3
33 COSM87577038 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.6715G>T p.V2239L 9:106974156-106974156 3
34 COSM109096265 ZNF462 liver,NS,carcinoma,hepatocellular carcinoma c.3433G>T p.V1145L 9:106974156-106974156 3
35 COSM104985080 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.298+23785G>T p.? 2:179745718-179745718 3
36 COSM104427909 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.20G>T p.S7I 2:179745718-179745718 3
37 COSM151538615 ZNF385B liver,NS,carcinoma,hepatocellular carcinoma c.253+23785G>T p.? 2:179745718-179745718 3
38 COSM127708351 ZNF345 liver,NS,carcinoma,hepatocellular carcinoma c.47-856A>T p.? 19:36891962-36891962 3
39 COSM135887725 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1168C>G p.L390V 16:89734008-89734008 3
40 COSM84511025 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1219C>G p.L407V 16:89734008-89734008 3
41 COSM111609487 ZNF276 liver,NS,carcinoma,hepatocellular carcinoma c.1444C>G p.L482V 16:89734008-89734008 3
42 COSM92353291 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.1010C>T p.T337I 12:133010889-133010889 3
43 COSM130415812 ZNF26 liver,NS,carcinoma,hepatocellular carcinoma c.950C>T p.T317I 12:133010889-133010889 3
44 COSM88697750 ZNF217 liver,NS,carcinoma,hepatocellular carcinoma c.*194A>T p.? 20:53569094-53569094 3
45 COSM95253159 ZNF217 liver,NS,carcinoma,hepatocellular carcinoma c.*194A>T p.? 20:53569094-53569094 3
46 COSM94505616 ZMYND12 liver,NS,carcinoma,hepatocellular carcinoma c.425-1G>T p.? 1:42440026-42440026 3
47 COSM89943752 ZMYM4 liver,NS,carcinoma,hepatocellular carcinoma c.86-8201G>T p.? 1:35350724-35350724 3
48 COSM101398456 ZIC2 liver,NS,carcinoma,hepatocellular carcinoma c.-18C>T p.? 13:99982047-99982047 3
49 COSM113521587 ZGPAT liver,NS,carcinoma,hepatocellular carcinoma c.*197C>A p.? 20:63736116-63736116 3
50 COSM94679661 ZGPAT liver,NS,carcinoma,hepatocellular carcinoma c.*197C>A p.? 20:63736116-63736116 3

Expression for Iron Overload in Africa

Search GEO for disease gene expression data for Iron Overload in Africa.

Pathways for Iron Overload in Africa

GO Terms for Iron Overload in Africa

Cellular components related to Iron Overload in Africa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 TFR2 TF TBCD SLC40A1 HJV HFE
2 basal part of cell GO:0045178 8.96 TF HFE
3 HFE-transferrin receptor complex GO:1990712 8.92 TFR2 TF HJV HFE

Biological processes related to Iron Overload in Africa according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.83 TF SLC40A1 HFE HEPH
2 acute-phase response GO:0006953 9.58 TFR2 HFE HAMP
3 BMP signaling pathway GO:0030509 9.55 HJV HFE
4 liver regeneration GO:0097421 9.54 HFE HAMP
5 transferrin transport GO:0033572 9.54 TFR2 TF HFE
6 positive regulation of receptor-mediated endocytosis GO:0048260 9.51 TF HFE
7 iron ion transport GO:0006826 9.5 TFR2 TF HEPH
8 iron ion homeostasis GO:0055072 9.5 TFR2 TF SLC40A1 HJV HFE HEPH
9 positive regulation of peptide hormone secretion GO:0090277 9.49 TFR2 HFE
10 multicellular organismal iron ion homeostasis GO:0060586 9.48 SLC40A1 HAMP
11 response to iron ion starvation GO:1990641 9.46 HFE HAMP
12 regulation of iron ion transport GO:0034756 9.43 TF HFE
13 response to iron ion GO:0010039 9.43 TFR2 HFE HAMP
14 cellular response to iron ion GO:0071281 9.33 TFR2 TF HFE
15 cellular iron ion homeostasis GO:0006879 9.17 TFR2 TF SLC40A1 HJV HFE HEPH

Molecular functions related to Iron Overload in Africa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.26 HEPH HAMP
2 ferrous iron binding GO:0008198 9.16 TF HEPH
3 co-receptor binding GO:0039706 8.96 TFR2 HFE
4 transferrin receptor binding GO:1990459 8.8 TF HJV HFE

Sources for Iron Overload in Africa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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