MCID: IRN008
MIFTS: 43

Iron Overload in Africa

Categories: Gastrointestinal diseases, Immune diseases, Liver diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Iron Overload in Africa

MalaCards integrated aliases for Iron Overload in Africa:

Name: Iron Overload in Africa 57 12 53
African Iron Overload 57 12 53 25 59 55 15
Bantu Siderosis 57 12 76 53 59 73
African Hemochromatosis 25 73
Hereditary Iron Overload and African Americans 53
African Nutritional Hemochromatosis 25
African Siderosis 25

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant plus dietary factor


Classifications:



External Ids:

OMIM 57 601195
Disease Ontology 12 DOID:0111033
ICD10 33 E83.1
Orphanet 59 ORPHA139507
ICD10 via Orphanet 34 E83.1
UMLS via Orphanet 74 C0268063
MedGen 42 C0268063

Summaries for Iron Overload in Africa

OMIM : 57 African iron overload is a distinct iron-loading disorder prevalent in Africa. Formerly termed Bantu siderosis, the disorder results from a predisposition to iron loading that is exacerbated by excessive intake of dietary iron. It is particularly a problem among Africans who drink a traditional beer brewed in non-galvanized steel drums. Although the disorder was once attributed to dietary excess alone, serious iron overload does not develop in all beer drinkers, and not all patients with iron overload consume excessive amounts of the beer (summary by Andrews, 1999). (601195)

MalaCards based summary : Iron Overload in Africa, also known as african iron overload, is related to siderosis and hemosiderosis. An important gene associated with Iron Overload in Africa is TF (Transferrin), and among its related pathways/superpathways are Insulin receptor recycling and Metal ion SLC transporters. Affiliated tissues include liver, bone and spleen, and related phenotypes are abnormality of metabolism/homeostasis and elevated transferrin saturation

Disease Ontology : 12 A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums.

Genetics Home Reference : 25 African iron overload is a condition that involves absorption of too much iron from the diet. The excess iron is stored in the body's tissues and organs, particularly the liver, bone marrow, and spleen. Humans cannot increase the excretion of iron, although some iron is lost through bleeding or when cells of the intestine (enterocytes) are shed at the end of the cells' lifespan. Iron levels in the body are primarily regulated through control of how much iron is absorbed from the diet.

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 139507Disease definitionAfrican iron overload is a rare disorder described in sub-Saharan African populations and is characterized by iron overload due to excess dietary iron intake and possibly genetic factors, leading to hepatic portal fibrosis and micronodular cirrhosis.Visit the Orphanet disease page for more resources.

Wikipedia : 76 African iron overload, also known as (Bantu siderosis, or Dietary iron overload), is an iron overload... more...

Related Diseases for Iron Overload in Africa

Diseases related to Iron Overload in Africa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 siderosis 30.6 HBB HFE SLC40A1 TF TFRC
2 hemosiderosis 30.0 HAMP HFE SLC40A1 TF TFRC
3 hemochromatosis, type 1 28.7 CASR HAMP HEPH HFE HP SLC40A1
4 hyperferritinemia with or without cataract 10.2 HFE TF
5 hfe-associated hereditary hemochromatosis 10.2 HFE TFR2
6 hypochromic microcytic anemia 10.2 HBB TF
7 folic acid deficiency anemia 10.2 TF TFRC
8 progressive bulbar palsy 10.1 HLA-A TF
9 angiomatous meningioma 10.1 TF TFRC
10 histoplasmosis 10.1 HLA-A TF
11 melancholia 10.1 HP TF
12 buruli ulcer 10.1 HBB SLC11A1
13 nontuberculous mycobacterial lung disease 10.1 HLA-A SLC11A1
14 congenital disorder of glycosylation, type ia 10.1 HP TF
15 pure red-cell aplasia 10.1 HLA-A TF
16 chondrocalcinosis 10.1 CASR HFE
17 malignant essential hypertension 10.0 HBB HLA-A
18 hemoglobinemia 10.0 HBB HP
19 hepatitis 10.0
20 hepatitis b 10.0
21 peritonitis 10.0
22 viral infectious disease 10.0
23 hemoglobin h disease 10.0 HBB TF TFRC
24 dysentery 10.0 HP TF
25 inherited metabolic disorder 10.0 HAMP HFE TF TFR2
26 hereditary spherocytosis 10.0 HBB HFE TFRC
27 glucosephosphate dehydrogenase deficiency 10.0 HBB HP
28 hemochromatosis, type 3 10.0 HAMP HFE SLC40A1 TFR2
29 anemia, sideroblastic, 1 10.0 HAMP HBB TFRC
30 congenital hemolytic anemia 10.0 HBB HP TF
31 hepatocellular carcinoma 9.9
32 rhizomelic chondrodysplasia punctata, type 2 9.9 HAMP HFE
33 porphyria cutanea tarda 9.9 HAMP HFE TF TFRC
34 thalassemia 9.9 HBB HFE TF TFRC
35 protein-energy malnutrition 9.9 HP TF
36 methemoglobinemia 9.9 HBB HP
37 hemochromatosis, type 4 9.9 HAMP HFE SLC40A1 TF TFR2
38 hemochromatosis type 2 9.9 HAMP HFE SLC40A1 TF TFR2
39 iron metabolism disease 9.9 HFE SLC40A1 TF TFR2 TFRC
40 alpha-thalassemia 9.9 HBB HP TFRC
41 beta-thalassemia 9.8 HBB HFE TF TFR2 TFRC
42 aceruloplasminemia 9.8 HAMP HEPH HFE TF TFR2
43 celiac disease 1 9.7 HFE HLA-A HP TFRC
44 hemoglobinopathy 9.7 HAMP HBB HFE HP TF
45 iron deficiency anemia 9.7 HAMP HFE SLC40A1 TF TFR2 TFRC
46 metal metabolism disorder 9.6 CASR HAMP HFE SLC40A1 TF TFR2
47 malaria 9.5 HAMP HBB HLA-A HP TF TFRC
48 atransferrinemia 9.3 HAMP HEPH HFE HP SLC40A1 TF
49 deficiency anemia 9.2 HAMP HBB HEPH HFE HP SLC40A1

Graphical network of the top 20 diseases related to Iron Overload in Africa:



Diseases related to Iron Overload in Africa

Symptoms & Phenotypes for Iron Overload in Africa

Symptoms via clinical synopsis from OMIM:

57
Lab:
elevated transferrin saturation

Misc:
increased dietary iron


Clinical features from OMIM:

601195

Human phenotypes related to Iron Overload in Africa:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 elevated transferrin saturation 32 HP:0012463

MGI Mouse Phenotypes related to Iron Overload in Africa:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CASR HEPH HFE HP SLC11A1 SLC40A1
2 digestive/alimentary MP:0005381 9.73 CASR HEPH HFE SLC11A1 SLC40A1 TFRC
3 immune system MP:0005387 9.56 CASR HEPH HFE HP SLC11A1 SLC40A1
4 liver/biliary system MP:0005370 9.1 HEPH HFE HP SLC40A1 TFR2 TFRC

Drugs & Therapeutics for Iron Overload in Africa

Search Clinical Trials , NIH Clinical Center for Iron Overload in Africa

Genetic Tests for Iron Overload in Africa

Anatomical Context for Iron Overload in Africa

MalaCards organs/tissues related to Iron Overload in Africa:

41
Liver, Bone, Spleen, Bone Marrow, Lung

Publications for Iron Overload in Africa

Articles related to Iron Overload in Africa:

(show all 12)
# Title Authors Year
1
Type 3 hereditary hemochromatosis in a patient from sub-Saharan Africa: is there a link between African iron overload and TFR2 dysfunction? ( 22981443 )
2013
2
African iron overload. ( 12382201 )
2002
3
African iron overload. ( 10881373 )
2000
4
Measurements of iron status and survival in African iron overload. ( 10554633 )
1999
5
Evidence of genetic transmission in African iron overload. ( 9446671 )
1998
6
African iron overload and hepatocellular carcinoma (HA-7-0-080). ( 9451425 )
1998
7
Is there a link between African iron overload and the described mutations of the hereditary haemochromatosis gene? ( 9753041 )
1998
8
Tuberculosis and iron overload in Africa: a review. ( 9631102 )
1997
9
Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited. ( 8605366 )
1996
10
Hepatocellular carcinoma and african iron overload. ( 8984039 )
1996
11
Hepatocellular carcinoma and African iron overload. ( 8549953 )
1995
12
Iron overload in Africa. Interaction between a gene and dietary iron content. ( 1727237 )
1992

Variations for Iron Overload in Africa

Expression for Iron Overload in Africa

Search GEO for disease gene expression data for Iron Overload in Africa.

Pathways for Iron Overload in Africa

GO Terms for Iron Overload in Africa

Cellular components related to Iron Overload in Africa according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.95 HAMP HBB HEPH HFE HP TF
2 integral component of plasma membrane GO:0005887 9.7 CASR HFE HLA-A SLC11A1 SLC40A1 TFR2
3 endosome membrane GO:0010008 9.67 SLC11A1 TF TFRC
4 recycling endosome GO:0055037 9.63 HFE TF TFRC
5 basolateral plasma membrane GO:0016323 9.56 CASR HEPH SLC40A1 TFRC
6 endocytic vesicle lumen GO:0071682 9.48 HBB HP
7 basal part of cell GO:0045178 9.43 HFE TF
8 haptoglobin-hemoglobin complex GO:0031838 9.37 HBB HP
9 MHC class I protein complex GO:0042612 9.32 HFE HLA-A
10 blood microparticle GO:0072562 9.26 HBB HP TF TFRC
11 HFE-transferrin receptor complex GO:1990712 8.92 HFE TF TFR2 TFRC

Biological processes related to Iron Overload in Africa according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.93 HEPH HFE SLC11A1 SLC40A1 TF
2 immune response GO:0006955 9.87 HAMP HFE HLA-A SLC11A1
3 receptor-mediated endocytosis GO:0006898 9.81 HBB HP TFR2 TFRC
4 acute-phase response GO:0006953 9.67 HAMP HFE HP TFR2
5 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
6 response to iron ion GO:0010039 9.61 HAMP HFE TFR2
7 antigen processing and presentation GO:0019882 9.58 HFE HLA-A
8 liver regeneration GO:0097421 9.58 HAMP HFE
9 cellular response to iron ion GO:0071281 9.58 HFE TF TFR2
10 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.56 HFE HLA-A
11 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A1 SLC40A1
12 positive regulation of receptor-mediated endocytosis GO:0048260 9.55 HFE TF
13 iron ion transport GO:0006826 9.55 HEPH SLC11A1 SLC40A1 TF TFR2
14 positive regulation of peptide hormone secretion GO:0090277 9.52 HFE TFR2
15 iron ion import GO:0097286 9.49 TFR2 TFRC
16 regulation of iron ion import GO:1900390 9.48 HFE TF
17 response to iron ion starvation GO:1990641 9.46 HAMP HFE
18 iron ion homeostasis GO:0055072 9.43 HEPH HFE SLC11A1 SLC40A1 TF TFR2
19 cellular iron ion homeostasis GO:0006879 9.23 HAMP HEPH HFE SLC11A1 SLC40A1 TF

Molecular functions related to Iron Overload in Africa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.43 HFE HLA-A
2 ferrous iron binding GO:0008198 9.4 HEPH TF
3 co-receptor binding GO:0039706 9.37 HFE TFR2
4 transferrin receptor binding GO:1990459 9.32 HFE TF
5 beta-2-microglobulin binding GO:0030881 9.26 HFE HLA-A
6 hemoglobin binding GO:0030492 9.16 HBB HP
7 transferrin receptor activity GO:0004998 8.96 TFR2 TFRC
8 transferrin transmembrane transporter activity GO:0033570 8.62 TFR2 TFRC

Sources for Iron Overload in Africa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....