MCID: IRN008
MIFTS: 32

Iron Overload in Africa

Categories: Rare diseases, Liver diseases, Metabolic diseases

Aliases & Classifications for Iron Overload in Africa

MalaCards integrated aliases for Iron Overload in Africa:

Name: Iron Overload in Africa 57 12 53
African Iron Overload 57 12 53 25 59 55
Bantu Siderosis 57 12 76 53 59 73
African Hemochromatosis 25 73
Hereditary Iron Overload and African Americans 53
African Nutritional Hemochromatosis 25
African Siderosis 25

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant plus dietary factor


Classifications:



External Ids:

OMIM 57 601195
Disease Ontology 12 DOID:0111033
ICD10 33 E83.1
Orphanet 59 ORPHA139507
ICD10 via Orphanet 34 E83.1
UMLS via Orphanet 74 C0268063
MedGen 42 C0268063

Summaries for Iron Overload in Africa

OMIM : 57 African iron overload is a distinct iron-loading disorder prevalent in Africa. Formerly termed Bantu siderosis, the disorder results from a predisposition to iron loading that is exacerbated by excessive intake of dietary iron. It is particularly a problem among Africans who drink a traditional beer brewed in non-galvanized steel drums. Although the disorder was once attributed to dietary excess alone, serious iron overload does not develop in all beer drinkers, and not all patients with iron overload consume excessive amounts of the beer (summary by Andrews, 1999). (601195)

MalaCards based summary : Iron Overload in Africa, also known as african iron overload, is related to siderosis and hemosiderosis. An important gene associated with Iron Overload in Africa is TF (Transferrin). Affiliated tissues include liver, spleen and bone, and related phenotypes are abnormality of metabolism/homeostasis and elevated transferrin saturation

Disease Ontology : 12 A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums.

Genetics Home Reference : 25 African iron overload is a condition that involves absorption of too much iron from the diet. The excess iron is stored in the body's tissues and organs, particularly the liver, bone marrow, and spleen. Humans cannot increase the excretion of iron, although some iron is lost through bleeding or when cells of the intestine (enterocytes) are shed at the end of the cells' lifespan. Iron levels in the body are primarily regulated through control of how much iron is absorbed from the diet.

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 139507Disease definitionAfrican iron overload is a rare disorder described in sub-Saharan African populations and is characterized by iron overload due to excess dietary iron intake and possibly genetic factors, leading to hepatic portal fibrosis and micronodular cirrhosis.Visit the Orphanet disease page for more resources.

Wikipedia : 76 African iron overload, also known as (Bantu siderosis, or Dietary iron overload), is an iron overload... more...

Related Diseases for Iron Overload in Africa

Diseases related to Iron Overload in Africa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 siderosis 30.2 HFE TF
2 hemosiderosis 29.7 HFE TF
3 hepatitis 9.9
4 hepatitis b 9.9
5 peritonitis 9.9
6 hepatocellular carcinoma 9.8
7 hyperferritinemia with or without cataract 9.7 HFE TF
8 metal metabolism disorder 9.7 HFE TF
9 iron metabolism disease 9.7 HFE TF
10 atransferrinemia 9.7 HFE TF
11 iron deficiency anemia 9.7 HFE TF
12 inherited metabolic disorder 9.7 HFE TF
13 porphyria cutanea tarda 9.6 HFE TF
14 wilson disease 9.6 HFE TF
15 porphyria 9.6 HFE TF
16 thalassemia 9.6 HFE TF
17 beta-thalassemia 9.6 HFE TF
18 aceruloplasminemia 9.5 HFE TF
19 hemochromatosis, type 1 9.5 HFE TF
20 deficiency anemia 9.4 HFE TF
21 liver cirrhosis 9.3 HFE TF
22 liver disease 9.2 HFE TF
23 myelodysplastic syndrome 9.0 HFE TF

Graphical network of the top 20 diseases related to Iron Overload in Africa:



Diseases related to Iron Overload in Africa

Symptoms & Phenotypes for Iron Overload in Africa

Symptoms via clinical synopsis from OMIM:

57
Lab:
elevated transferrin saturation

Misc:
increased dietary iron


Clinical features from OMIM:

601195

Human phenotypes related to Iron Overload in Africa:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 elevated transferrin saturation 32 HP:0012463

Drugs & Therapeutics for Iron Overload in Africa

Search Clinical Trials , NIH Clinical Center for Iron Overload in Africa

Genetic Tests for Iron Overload in Africa

Anatomical Context for Iron Overload in Africa

MalaCards organs/tissues related to Iron Overload in Africa:

41
Liver, Spleen, Bone, Bone Marrow

Publications for Iron Overload in Africa

Articles related to Iron Overload in Africa:

# Title Authors Year
1
Type 3 hereditary hemochromatosis in a patient from sub-Saharan Africa: is there a link between African iron overload and TFR2 dysfunction? ( 22981443 )
2013
2
African iron overload. ( 12382201 )
2002
3
Measurements of iron status and survival in African iron overload. ( 10554633 )
1999
4
Evidence of genetic transmission in African iron overload. ( 9446671 )
1998
5
Tuberculosis and iron overload in Africa: a review. ( 9631102 )
1997
6
Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited. ( 8605366 )
1996
7
Iron overload in Africa. Interaction between a gene and dietary iron content. ( 1727237 )
1992

Variations for Iron Overload in Africa

Expression for Iron Overload in Africa

Search GEO for disease gene expression data for Iron Overload in Africa.

Pathways for Iron Overload in Africa

GO Terms for Iron Overload in Africa

Cellular components related to Iron Overload in Africa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.37 HFE TF
2 perinuclear region of cytoplasm GO:0048471 9.32 HFE TF
3 early endosome GO:0005769 9.26 HFE TF
4 recycling endosome GO:0055037 9.16 HFE TF
5 basal part of cell GO:0045178 8.96 HFE TF
6 HFE-transferrin receptor complex GO:1990712 8.62 HFE TF

Biological processes related to Iron Overload in Africa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.4 HFE TF
2 cellular iron ion homeostasis GO:0006879 9.37 HFE TF
3 iron ion homeostasis GO:0055072 9.32 HFE TF
4 transferrin transport GO:0033572 9.26 HFE TF
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.16 HFE TF
6 cellular response to iron ion GO:0071281 8.96 HFE TF
7 regulation of iron ion import GO:1900390 8.62 HFE TF

Molecular functions related to Iron Overload in Africa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferrin receptor binding GO:1990459 8.62 HFE TF

Sources for Iron Overload in Africa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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