MCID: IRR001
MIFTS: 32

Irregular Astigmatism

Categories: Neuronal diseases

Aliases & Classifications for Irregular Astigmatism

MalaCards integrated aliases for Irregular Astigmatism:

Name: Irregular Astigmatism 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13919
ICD9CM 34 367.22
SNOMED-CT 67 47099006
ICD10 32 H52.21
UMLS 70 C0152194

Summaries for Irregular Astigmatism

MalaCards based summary : Irregular Astigmatism is related to keratoconus 1 and regular astigmatism. An important gene associated with Irregular Astigmatism is VSX1 (Visual System Homeobox 1), and among its related pathways/superpathways are Cell adhesion_Endothelial cell contacts by non-junctional mechanisms and NCAM1 interactions. The drugs Dipivefrin and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are hearing/vestibular/ear and vision/eye

Related Diseases for Irregular Astigmatism

Diseases related to Irregular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 keratoconus 1 32.0 ZNF469 VSX1
2 regular astigmatism 31.4 ZNF469 VSX1
3 astigmatism 31.0 ZNF469 VSX1 KRT3 KRT12 KERA
4 recurrent corneal erosion 29.5 TGFBI KRT3 KRT12 COL8A2
5 corneal edema 29.0 VSX1 TGFBI SLC4A11 KRT3 KERA COL8A2
6 keratoconus 28.3 ZNF469 VSX1 TGFBI SLC4A11 RAB3GAP1 PRDM5
7 corneal dystrophy 28.0 VSX1 TGFBI SLC4A11 KRT3 KRT12 KERA
8 corneal ectasia 27.9 ZNF765 ZNF469 VSX1 TGFBI RAB3GAP1 KRT3
9 fuchs' endothelial dystrophy 26.9 ZNF469 VSX1 TGFBI SLC4A11 RAB3GAP1 KRT3
10 keratoconus posticus circumscriptus 11.0
11 keratoconus 5 11.0
12 myopia 10.4
13 refractive error 10.4
14 cataract 10.4
15 epithelial basement membrane dystrophy 10.2 TGFBI KRT3
16 corneal dystrophy, lisch epithelial 10.2 KRT3 KRT12
17 corneal dystrophy, groenouw type i 10.2 TGFBI KRT12
18 ocular motor apraxia 10.2
19 limbal stem cell deficiency 10.2 KRT3 KRT12
20 keratitis, hereditary 10.1
21 keratopathy 10.1
22 pellucid marginal degeneration 10.1
23 brittle cornea syndrome 10.1 ZNF469 PRDM5
24 brittle cornea syndrome 1 10.1 ZNF469 PRDM5
25 iris disease 10.1 KRT3 KRT12
26 corneal deposit 10.1 TGFBI KRT3 KRT12
27 corneal dystrophy, reis-bucklers type 10.1 TGFBI KRT3 KRT12
28 corneal dystrophy, thiel-behnke type 10.1 TGFBI KRT3 KRT12
29 corneal dystrophy, avellino type 10.1 TGFBI KRT3 KRT12
30 anti-basement membrane glomerulonephritis 10.1 COL4A4 COL4A3
31 schnyder corneal dystrophy 10.1 TGFBI KRT3 KRT12
32 lattice corneal dystrophy 10.1 TGFBI KRT3 KRT12
33 alport syndrome 3, autosomal dominant 10.1 COL4A4 COL4A3
34 x-linked alport syndrome 10.1 COL4A4 COL4A3
35 autoimmune disease of urogenital tract 10.1 COL4A4 COL4A3
36 rapidly progressive glomerulonephritis 10.1 COL4A4 COL4A3
37 pierson syndrome 10.0 COL4A4 COL4A3
38 autosomal dominant alport syndrome 10.0 COL4A4 COL4A3
39 pseudopterygium 10.0 SLC4A11 KRT3 KRT12
40 martsolf syndrome 10.0 ZNF469 RAB3GAP1
41 goodpasture syndrome 10.0 COL4A4 COL4A3
42 corneal ulcer 10.0 KRT3 KERA
43 osgood-schlatter's disease 10.0 VSX1 COL8A2
44 brittle bone disorder 10.0 ZNF469 VSX1 PRDM5
45 keratoconus 2 10.0
46 myopia 15, autosomal dominant 10.0
47 keratoconus 8 10.0
48 ifap syndrome 2 10.0
49 anisometropia 10.0
50 endophthalmitis 10.0

Graphical network of the top 20 diseases related to Irregular Astigmatism:



Diseases related to Irregular Astigmatism

Symptoms & Phenotypes for Irregular Astigmatism

MGI Mouse Phenotypes related to Irregular Astigmatism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.43 COL4A3 COL4A4 PRDM5 RAB3GAP1 SLC4A11 ZNF469
2 vision/eye MP:0005391 9.28 COL4A3 COL4A4 COL8A2 KERA KRT12 PRDM5

Drugs & Therapeutics for Irregular Astigmatism

Drugs for Irregular Astigmatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 3 52365-63-6 3105
2
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
3
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
4 Pharmaceutical Solutions Phase 3
5 Vitamin B9 Phase 3
6 Nutrients Phase 3
7 Trace Elements Phase 3
8 Micronutrients Phase 3
9 Ophthalmic Solutions Phase 3
10 Photosensitizing Agents Phase 3
11 Vitamins Phase 3
12 Vitamin B Complex Phase 3
13 Vitamin B2 Phase 3
14 Folate Phase 3
15 Dermatologic Agents Phase 3
16 Mitomycins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study Evaluating the Safety and Efficacy of the KXL System With vibeX Rapid (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes Having Keratoconus and Post LASIK Ectasia Unknown status NCT02638376 Phase 3
2 Study of the Safety and Effectiveness of Photochemically Induced Collagen Cross- Linking at Higher Irradiances in Patients With Keratoconus or Ectasia Unknown status NCT01789333 Riboflavin 0.1% ophthalmic solution
3 The Role of Anterior Segment Optical Coherence Tomography in Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking. Unknown status NCT03879421
4 Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea Completed NCT03140046
5 "Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Intrastromal Corneal Ring for Treatment of Keratoconus and Others Irregulars Astigmatisms." Completed NCT00832897
6 Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus or Irregular Astigmatism Recruiting NCT04698590
7 Increasing CrossLinking of Corneal Collagen in Eyes With Progressive Keratoconus or Ectasia No longer available NCT01384773

Search NIH Clinical Center for Irregular Astigmatism

Genetic Tests for Irregular Astigmatism

Anatomical Context for Irregular Astigmatism

MalaCards organs/tissues related to Irregular Astigmatism:

40
Eye, Endothelial

Publications for Irregular Astigmatism

Articles related to Irregular Astigmatism:

(show top 50) (show all 682)
# Title Authors PMID Year
1
Scleral contact lenses: Visual outcomes and tolerance. A prospective study about 98 eyes. 61
33549353 2021
2
[Excimer laser in keratoconus management]. 61
33573798 2021
3
CLEAR - Medical use of contact lenses. 61
33775381 2021
4
Quantitative comparison of corneal surface areas in keratoconus and normal eyes. 61
33767220 2021
5
Repeated rotation of a toric implantable collamer lens: A case report. 61
33725870 2021
6
Fourier Analysis on Regular and Irregular Astigmatism of Anterior and Posterior Corneal Surfaces in Fuchs Endothelial Corneal Dystrophy. 61
33039376 2021
7
Outcomes of three surgical approaches for managing ectopia lentis in Marfan syndrome. 61
33550842 2021
8
Pediatric keratoconus - Current perspectives and clinical challenges. 61
33463562 2021
9
Ocular manifestations in classic homocystinuria. 61
32940091 2021
10
Evaluation of the quality of life related to vision after penetrating keratoplasty. 61
32861525 2021
11
Myopic outcomes after excimer laser phototherapeutic keratectomy (PTK). 61
33158609 2021
12
Handling regular and irregular astigmatism during cataract surgery. 61
33196544 2021
13
Prevalence of epiretinal membrane in the phakic eyes based on spectral-domain optical coherence tomography. 61
33411853 2021
14
[Implantation of a small-aperture intraocular lens (IOL) in two patients with irregular astigmatism after keratorefractive surgery]. 61
33275175 2020
15
Awareness level of general population regarding keratoconus in Aseer region, Southern of Saudi Arabia. 61
33681056 2020
16
Corneoscleral contact lenses for visual rehabilitation after keratoplasty surgery. 61
32456950 2020
17
Biochemical Markers and Alterations in Keratoconus. 61
33323707 2020
18
Corneal collagen cross-linking in pediatric keratoconus with three protocols: a systematic review and meta-analysis. 61
33279597 2020
19
Case Report: Use of Prosthetic Replacement of the Ocular Surface Ecosystem Treatment of Traumatic Lid Ptosis in a Pediatric Patient. 61
33259377 2020
20
Phototherapeutic keratectomy: Indications, methods and decision making. 61
33229661 2020
21
Corneal cross-linking (CXL) combined with refractive surgery for the comprehensive management of keratoconus: CXL plus. 61
33229651 2020
22
Keratoconus progression after intrastromal corneal ring segment implantation according to age: 5-year follow-up cohort study. 61
32562024 2020
23
Topography-Guided Custom Ablation Photorefractive Keratectomy Treatment of Irregular Astigmatism Resulting From Decentered SMILE. 61
33170284 2020
24
Corneal Topography for Intraocular Lens Selection in Refractive Cataract Surgery. 61
33221325 2020
25
Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus. 61
32971611 2020
26
Ocular and adnexal anomalies in craniofacial microsomia: a systematic review. 61
32217034 2020
27
Need for explantation of an intrastromal titan ring after penetrating keratoplasty in two patients. 61
32993369 2020
28
Kahook Dual Blade goniotomy in post penetrating keratoplasty steroid-induced ocular hypertension. 61
32685769 2020
29
Late-onset corneal haze after intrastromal corneal ring implantation in an eye with previous topography-guided PRK. 61
32695929 2020
30
Penetrating keratoplasty after complicated small incision lenticule extraction a case report. 61
32637727 2020
31
Atypical Corneal Ectasia Associated With Vitamin C Deficiency. 61
32301811 2020
32
Whole exome sequencing highlights variants in association with Keratoconus in Jordanian families. 61
32887565 2020
33
Update on Contact Lens Treatment of Keratoconus 61
32854468 2020
34
Association of TIMP-1 and COL4A4 Gene Polymorphisms with Keratoconus in an Iranian Population. 61
32864060 2020
35
Multi-view deep learning for rigid gas permeable lens base curve fitting based on Pentacam images. 61
32363555 2020
36
Use of new-generation hybrid contact lenses for managing challenging corneas. 61
32668981 2020
37
8.5/8.6-mm Excimer Laser-Assisted Penetrating Keratoplasties in a Tertiary Corneal Subspecialty Referral Center: Indications and Outcomes in 107 Eyes. 61
32265385 2020
38
Implantation of a small-aperture intraocular lens and a partial aniridia implant in eyes with traumatic iris defects. 61
32215345 2020
39
Short-term, high-dose hydroxychloroquine corneal toxicity. 61
32346653 2020
40
A new technique for fitting of tricurve rigid gas-permeable contact lens in penetrating keratoplasty eyes using Scheimpflug imaging. 61
32461429 2020
41
Triamcinolone acetonide for remnant lenticule identification in small incision lenticule extraction. 61
32079839 2020
42
Correction of Irregular Astigmatism With New-Generation Hybrid Contact Lenses. 61
31145208 2020
43
Factors predicting successful customized excimer laser treatment in irregular corneas. 61
32126038 2020
44
Association of Postfungal Keratitis Corneal Scar Features With Visual Acuity. 61
31804657 2020
45
Comparison of accelerated CXL alone, accelerated CXL-ICRS, and accelerated CXL-TG-PRK in progressive keratoconus and other corneal ectasias. 61
32126042 2020
46
Contact Lenses in the Management of Corneal Dystrophies. 61
30736080 2020
47
[Intraocular correction of ametropia in patients with keratoconus]. 61
33056973 2020
48
A Modified Customized Rigid Gas Permeable Contact Lens to Improve Visualization During Phacoemulsification in Ectatic Corneas. 61
31976337 2020
49
Choroidal thickness in keratoconus. 61
31432355 2020
50
Bilateral corneal keloids after eyelid compression. 61
32309126 2020

Variations for Irregular Astigmatism

Expression for Irregular Astigmatism

Search GEO for disease gene expression data for Irregular Astigmatism.

Pathways for Irregular Astigmatism

Pathways related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.56 COL4A4 COL4A3
2 10.19 COL4A4 COL4A3

GO Terms for Irregular Astigmatism

Cellular components related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.62 TGFBI COL8A2 COL4A4 COL4A3
2 collagen trimer GO:0005581 9.43 COL8A2 COL4A4 COL4A3
3 extracellular matrix GO:0031012 9.35 TGFBI KERA COL8A2 COL4A4 COL4A3
4 collagen type IV trimer GO:0005587 9.16 COL4A4 COL4A3
5 basement membrane GO:0005604 8.92 TGFBI COL8A2 COL4A4 COL4A3

Biological processes related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornea development in camera-type eye GO:0061303 9.26 KRT12 KERA
2 extracellular matrix organization GO:0030198 9.26 TGFBI COL8A2 COL4A4 COL4A3
3 glomerular basement membrane development GO:0032836 9.16 COL4A4 COL4A3
4 visual perception GO:0007601 8.92 VSX1 TGFBI KRT12 KERA

Molecular functions related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL8A2 COL4A4 COL4A3
2 extracellular matrix structural constituent GO:0005201 8.92 TGFBI COL8A2 COL4A4 COL4A3

Sources for Irregular Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....