MCID: IRR001
MIFTS: 27

Irregular Astigmatism

Categories: Eye diseases

Aliases & Classifications for Irregular Astigmatism

MalaCards integrated aliases for Irregular Astigmatism:

Name: Irregular Astigmatism 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13919
ICD10 33 H52.21
ICD9CM 35 367.22
SNOMED-CT 68 47099006
UMLS 73 C0152194

Summaries for Irregular Astigmatism

MalaCards based summary : Irregular Astigmatism is related to keratoconus and keratoconus 1. An important gene associated with Irregular Astigmatism is NYX (Nyctalopin). The drugs Lidocaine and Flavin Mononucleotide have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotype is Nucleoplasmic pre-40S maturation defects.

Related Diseases for Irregular Astigmatism

Diseases related to Irregular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 keratoconus 11.5
2 keratoconus 1 11.1
3 keratoconus 5 11.1
4 astigmatism 11.0
5 cataract 10.2
6 myopia 10.0
7 anisometropia 10.0
8 corneal ectasia 10.0

Graphical network of the top 20 diseases related to Irregular Astigmatism:



Diseases related to Irregular Astigmatism

Symptoms & Phenotypes for Irregular Astigmatism

GenomeRNAi Phenotypes related to Irregular Astigmatism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Nucleoplasmic pre-40S maturation defects GR00209-A-1 8.62 RPS27 RPS29

Drugs & Therapeutics for Irregular Astigmatism

Drugs for Irregular Astigmatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
2
Flavin Mononucleotide Approved, Investigational Phase 2, Phase 3 146-17-8 643976
3
Dipivefrin Approved Phase 3 52365-63-6 3105
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 59-30-3 6037
5
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 83-88-5 493570
6 Diuretics, Potassium Sparing Phase 2, Phase 3
7 Trace Elements Phase 2, Phase 3,Phase 3,Not Applicable
8 Photosensitizing Agents Phase 2, Phase 3,Phase 3,Not Applicable
9 Anesthetics Phase 2, Phase 3
10 Vitamin B9 Phase 2, Phase 3,Phase 3,Not Applicable
11 Vitamins Phase 2, Phase 3,Phase 3,Not Applicable
12 Dermatologic Agents Phase 2, Phase 3,Phase 3,Not Applicable
13 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3,Not Applicable
14 Anesthetics, Local Phase 2, Phase 3
15 Dextrans Phase 2, Phase 3
16 Anti-Arrhythmia Agents Phase 2, Phase 3
17 Sodium Channel Blockers Phase 2, Phase 3
18 Folate Phase 2, Phase 3,Phase 3,Not Applicable
19 Peripheral Nervous System Agents Phase 2, Phase 3
20 Vitamin B Complex Phase 2, Phase 3,Phase 3,Not Applicable
21 Vitamin B2 Phase 2, Phase 3,Phase 3,Not Applicable
22 Central Nervous System Depressants Phase 2, Phase 3
23 Micronutrients Phase 2, Phase 3,Phase 3,Not Applicable
24 Mitomycins Phase 3
25 Ophthalmic Solutions Phase 3,Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Treatment of Keratoconus Using Collagen Cross-Linking Unknown status NCT00841386 Phase 2, Phase 3 Riboflavin-5-phosphate;Sham cross-linking
2 Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus Unknown status NCT02638376 Phase 3
3 Corneal Cross Linking and Topography Guided Excimer Laser Treatment Terminated NCT01682993 Phase 3
4 Measurement Repeatability in Contemporary Aberrometry Unknown status NCT02687022 Not Applicable
5 Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders Unknown status NCT02444923 Not Applicable
6 Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases Unknown status NCT02932852 Early Phase 1
7 Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring Completed NCT00832897 Not Applicable
8 Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer Completed NCT01861925
9 Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea Recruiting NCT03140046 Not Applicable
10 Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear Recruiting NCT02894489 Not Applicable
11 Biomechanical Properties of Keratoconic Eyes Recruiting NCT02476149
12 Higher Irradiance in Keratoconus Ectasia Recruiting NCT01789333 Not Applicable Riboflavin 0.1% ophthalmic solution
13 Astigmatism in Keratoconus Patients Not yet recruiting NCT03450213 Not Applicable
14 Progressive Keratoconus or Ectasia Treatment Plan No longer available NCT01384773

Search NIH Clinical Center for Irregular Astigmatism

Genetic Tests for Irregular Astigmatism

Anatomical Context for Irregular Astigmatism

MalaCards organs/tissues related to Irregular Astigmatism:

41
Eye, Endothelial

Publications for Irregular Astigmatism

Articles related to Irregular Astigmatism:

(show top 50) (show all 87)
# Title Authors Year
1
Role of Hemidivisional Corneal Topographic Astigmatisms (CorTs) in the Regularization and Reduction of Irregular Astigmatism. ( 29135603 )
2018
2
Visual Outcomes and Aberrometric Changes With Topography-Guided Photorefractive Keratectomy Treatment of Irregular Astigmatism After Penetrating Keratoplasty. ( 29215394 )
2018
3
Corneal Irregular Astigmatism and Curvature Changes After Small Incision Lenticule Extraction: Three-Year Follow-Up. ( 29757850 )
2018
4
Irregular Astigmatism and Higher-Order Aberrations in Eyes With Dry Eye Disease. ( 30481804 )
2018
5
Fourier Analysis of Corneal Irregular Astigmatism Due to the Anterior Corneal Surface in Dry Eye. ( 30550406 )
2018
6
Repair of Irregularly Irregular Astigmatism by Transepithelial Phototherapeutic Keratectomy. ( 28991341 )
2017
7
Stepwise Guided Photorefractive Keratectomy in Treatment of Irregular Astigmatism After Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty. ( 28914632 )
2017
8
Validity of autorefractor based screening method for irregular astigmatism compared to the corneal topography- a cross sectional study. ( 28944202 )
2017
9
Safety and efficacy of femtosecond laser-assisted arcuate keratotomy to treat irregular astigmatism after penetrating keratoplasty. ( 26189378 )
2015
10
Stromal surface topography-guided custom ablation as a repair tool for corneal irregular astigmatism. ( 25599543 )
2015
11
Effects of corneal irregular astigmatism on visual acuity after conventional and femtosecond laser-assisted Descemet's stripping automated endothelial keratoplasty. ( 26028117 )
2015
12
Irregular Astigmatism After Corneal Transplantation-Efficacy and Safety of Topography-Guided Treatment. ( 26509761 )
2015
13
Visual outcomes of topography-guided excimer laser surgery for treatment of patients with irregular astigmatism. ( 23435799 )
2014
14
Topography-guided photorefractive keratectomy for irregular astigmatism after small incision lenticule extraction. ( 24972410 )
2014
15
Transepithelial phototherapeutic keratectomy protocol for treating irregular astigmatism based on population epithelial thickness measurements by artemis very high-frequency digital ultrasound. ( 24972404 )
2014
16
Incidence of irregular astigmatism eligible for contact lens fitting after Descemet membrane endothelial keratoplasty. ( 23664354 )
2013
17
Topography-guided transepithelial photorefractive keratectomy for irregular astigmatism using a 213 nm solid-state laser. ( 23158680 )
2013
18
Irregular astigmatism after femtosecond laser refractive lenticule extraction. ( 23688883 )
2013
19
Wearing time as a measure of success of scleral lenses for patients with irregular astigmatism. ( 24145901 )
2013
20
Intrastromal corneal ring segment implantation for irregular astigmatism after laser in situ keratomileusis. ( 22520312 )
2012
21
Advanced topography-guided (OcuLink) treatment of irregular astigmatism after epikeratophakia in keratoconus with the WaveLight excimer laser. ( 22094961 )
2012
22
Customized photorefractive keratectomy for the correction of regular and irregular astigmatism after penetrating keratoplasty. ( 21912229 )
2011
23
Toric soft contact lens fit in a postoperative LASIK keratoectasia patient with high and irregular astigmatism. ( 22019833 )
2011
24
Recovery of corneal irregular astigmatism, ocular higher-order aberrations, and contrast sensitivity after discontinuation of overnight orthokeratology. ( 19019936 )
2009
25
Severe hyperopic shift and irregular astigmatism after radial keratotomy. ( 19812501 )
2009
26
Femtosecond-assisted astigmatic keratotomy for post-keratoplasty irregular astigmatism. ( 19101418 )
2009
27
Irregular astigmatism after cataract surgery resulting from inadequate clear corneal incision formation. ( 19034136 )
2008
28
Management of irregular astigmatism following rotationally disoriented free cap after LASIK. ( 18500089 )
2008
29
Topographic customized photorefractive keratectomy for regular and irregular astigmatism after penetrating keratoplasty using the LIGI CIPTA/LaserSight platform. ( 17912938 )
2007
30
Longitudinal changes in corneal irregular astigmatism and visual acuity in eyes with keratoconus. ( 17660986 )
2007
31
Topography-guided ablation for treatment of patients with irregular astigmatism. ( 17326350 )
2007
32
Phototherapeutic keratectomy for epithelial irregular astigmatism: an emphasis on map-dot-fingerprint degeneration. ( 17269244 )
2007
33
Topography-guided treatment of irregular astigmatism with the wavelight excimer laser. ( 16629063 )
2006
34
Strategic planning in topography-guided ablation of irregular astigmatism after laser refractive surgery. ( 16128335 )
2005
35
Corneal irregular astigmatism after hyperopic laser in situ keratomileusis. ( 16160493 )
2005
36
Corneal regular and irregular astigmatism assessed by Fourier analysis of videokeratography data in normal and pathologic eyes. ( 15051209 )
2004
37
Treatment of irregular astigmatism with a 213 nm solid-state, diode-pumped neodymium:YAG ablative laser. ( 15474828 )
2004
38
Intraocular lens calculations in patients with corneal scarring and irregular astigmatism. ( 12900244 )
2003
39
Topographically guided ablations for the correction of irregular astigmatism after corneal surgery. ( 12881654 )
2003
40
RGP lens treats irregular astigmatism from intracorneal glass. ( 12861118 )
2003
41
Topography-guided laser in situ keratomileusis (TOPOLINK) to correct irregular astigmatism after previous refractive surgery. ( 14518740 )
2003
42
Treatment of irregular astigmatism and keratoconus with the VISX C-CAP method. ( 12881653 )
2003
43
Consultation section. Refractive surgical problem: irregular astigmatism in the left eye. ( 12551660 )
2003
44
Management of irregular astigmatism after laser in situ keratomileusis. ( 12881656 )
2003
45
Fourier analysis of induced irregular astigmatism. Photorefractive keratectomy versus laser in situ keratomileusis in a bilateral cohort of hyperopic patients. ( 14522289 )
2003
46
Management of irregular astigmatism induced by laser in situ keratomileusis. ( 12881655 )
2003
47
Contact lens fitting to correct irregular astigmatism after corneal refractive surgery. ( 12388023 )
2002
48
Correction of irregular astigmatism. ( 11927414 )
2002
49
Evaluation of lenticular irregular astigmatism using wavefront analysis in patients with lenticonus. ( 12365924 )
2002
50
Soft contact lenses for irregular astigmatism after laser in situ keratomileusis. ( 11758989 )
2001

Variations for Irregular Astigmatism

Expression for Irregular Astigmatism

Search GEO for disease gene expression data for Irregular Astigmatism.

Pathways for Irregular Astigmatism

GO Terms for Irregular Astigmatism

Cellular components related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosolic small ribosomal subunit GO:0022627 8.62 RPS27 RPS29

Biological processes related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 translational initiation GO:0006413 9.16 RPS27 RPS29
2 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 8.96 RPS27 RPS29
3 SRP-dependent cotranslational protein targeting to membrane GO:0006614 8.62 RPS27 RPS29

Sources for Irregular Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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