MCID: IRR003
MIFTS: 46

Irritant Dermatitis

Categories: Skin diseases

Aliases & Classifications for Irritant Dermatitis

Summaries for Irritant Dermatitis

MalaCards based summary : Irritant Dermatitis, also known as dermatitis, irritant, is related to skin conditions and erysipelas. An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Allograft rejection and Keratinization. The drugs Glycerol and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver.

Wikipedia : 76 Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 skin conditions 30.3 IL1A TNF
2 erysipelas 30.1 PI3 TNF
3 allergic contact dermatitis 30.1 FLG IL1B TNF
4 dermatitis, atopic 30.0 FLG MS4A2 TNF
5 contact dermatitis 29.9 FLG IL1A IL1B KRT16 TNF
6 skin disease 29.8 FLG IL1A KRT16 PI3 TNF
7 psoriasis 29.4 FLG IL1A IL1B KRT16 PI3 TNF
8 dermatitis 10.8
9 chronic follicular conjunctivitis 10.2 IL1A IL1B
10 discoid lupus erythematosus 10.2 FLG KRT16
11 esophagitis, eosinophilic, 1 10.2 FLG IER3IP1
12 dysentery 10.2 IER3IP1 IL1A
13 limbal stem cell deficiency 10.2 IL1A IL1B
14 chronic graft versus host disease 10.2 IL1A TNF
15 meningococcemia 10.2 IL1A IL1B
16 melancholia 10.2 IER3IP1 TNF
17 post-transplant lymphoproliferative disease 10.2 IL1A TNF
18 gingival disease 10.2 IL1A IL1B
19 multidrug-resistant tuberculosis 10.2 IL1A TNF
20 exudative glomerulonephritis 10.2 IL1B TNF
21 orofacial granulomatosis 10.2 FLG TNF
22 staphylococcal toxic shock syndrome 10.2 IL1B TNF
23 kashin-beck disease 10.1 IL1B TNF
24 rheumatoid lung disease 10.1 IL1B TNF
25 vulvar vestibulitis syndrome 10.1 IL1B TNF
26 lichen disease 10.1 FLG TNF
27 burns 10.1 IL1B TNF
28 glossitis 10.1 IL1B TNF
29 laryngitis 10.1 IL1B TNF
30 haemophilus influenzae 10.1 IL1B TNF
31 opisthorchiasis 10.1 IL1B TNF
32 erythema multiforme 10.1
33 retinitis pigmentosa 60 10.1 IL1B TNF
34 acute vascular insufficiency of intestine 10.1 IL1B TNF
35 congenital cytomegalovirus 10.1 IL1B TNF
36 actinic prurigo 10.1 IL1B TNF
37 osteosclerotic myeloma 10.1 IL1B TNF
38 root resorption 10.1 IL1A IL1B
39 palmoplantar keratoderma, epidermolytic 10.1 FLG KRT16
40 crohn's colitis 10.1 IL1B TNF
41 poems syndrome 10.1 IL1B TNF
42 periapical periodontitis 10.1 IL1B TNF
43 cholesteatoma of middle ear 10.1 FLG IL1A KRT16
44 central nervous system vasculitis 10.1 IL1B TNF
45 jejunoileitis 10.1 IL1B TNF
46 endometrial disease 10.1 IL1B TNF
47 rosacea 10.1 IER3IP1 TNF
48 dental pulp disease 10.1 IL1B TNF
49 primary systemic mycosis 10.1 IL1B TNF
50 eales disease 10.1 IL1B TNF

Graphical network of the top 20 diseases related to Irritant Dermatitis:



Diseases related to Irritant Dermatitis

Symptoms & Phenotypes for Irritant Dermatitis

Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4 56-81-5 753
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
4
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
5
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 5311051 32798
6 triamcinolone acetonide Phase 4,Phase 2
7 Hormones Phase 4,Phase 2
8 Triamcinolone diacetate Phase 4,Phase 2
9 Calcineurin Inhibitors Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
11 Immunosuppressive Agents Phase 4,Phase 2
12 Dermatologic Agents Phase 4,Not Applicable
13 glucocorticoids Phase 4,Phase 2
14 Triamcinolone hexacetonide Phase 4,Phase 2
15 Emollients Phase 4,Not Applicable
16 Anti-Inflammatory Agents Phase 4,Phase 2
17 Hormone Antagonists Phase 4,Phase 2
18 Immunologic Factors Phase 4,Phase 2
19 Protective Agents Phase 4
20
Timolol Approved Phase 3 26839-75-8 33624 5478
21
Maleic acid Experimental Phase 3 110-16-7 444266
22 Ophthalmic Solutions Phase 3
23 Neurotransmitter Agents Phase 3
24 Antihypertensive Agents Phase 3
25 Adrenergic Antagonists Phase 3
26 Adrenergic beta-Antagonists Phase 3
27 Pharmaceutical Solutions Phase 3
28 Adrenergic Agents Phase 3
29 Anti-Arrhythmia Agents Phase 3
30
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
31 Antineoplastic Agents, Alkylating Phase 2
32 Alkylating Agents Phase 2
33 Nitrogen Mustard Compounds Phase 2
34 Anesthetics

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation Unknown status NCT00779792 Phase 4 clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
2 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
3 Mechlorethamine Induced Contact Dermatitis Avoidance Study Recruiting NCT03380026 Phase 2 Triamcinolone;Valchlor 0.016 % Topical Gel
4 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453 Not Applicable
5 Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery Completed NCT03231813 Not Applicable
6 Effect of Tetrix on Alleviation of Burning,Itching Associated With Lesions of Contact Dermatitis Completed NCT00646867 Not Applicable
7 Risk Factors for Incontinence-Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence Completed NCT02996357
8 Prospective Single Center Randomized Double Blind Controlled Tolerability Trial of Six Hair Cleansing Conditioners Recruiting NCT03483025 Not Applicable
9 Histopathological Comparison Between Superficial Pressure Ulcers and Incontinence-associated Dermatitis Not yet recruiting NCT03685929
10 Preliminary Evaluation of CASTLE Barrier Prototype UK Terminated NCT01530087 Not Applicable
11 Comparison of Wash Wipes and Standard Care in the Prevention of Incontinence-associated Dermatitis in Elderly Terminated NCT02475512 Not Applicable
12 Vulvar Contact Dermatitis Resulting From Urine Incontinence Withdrawn NCT01320046

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

Genetic Tests for Irritant Dermatitis

Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

41
Skin, Lung, Liver, Bone, Lymph Node, Tonsil, Prostate

Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 80)
# Title Authors Year
1
Immediate irritant dermatitis from the passionvine hopper (Scolypopa australis). ( 29869388 )
2018
2
Histomorphology and Immunophenotype of Eczematous Skin Lesions Revisited-Skin Biopsies Are Not Reliable in Differentiating Allergic Contact Dermatitis, Irritant Contact Dermatitis, and Atopic Dermatitis. ( 28296664 )
2018
3
Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. ( 30145688 )
2018
4
Non-glaucoma periocular allergic, atopic, and irritant dermatitis at an academic institution: A retrospective review. ( 29985741 )
2018
5
Preapplication of white petroleum jelly to adjacent skin to prevent aluminum chloride-induced irritant dermatitis. ( 28619576 )
2017
6
Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis. ( 28774591 )
2017
7
N-acyl ethanolamide and eicosanoid involvement in irritant dermatitis. ( 26947140 )
2016
8
To evaluate the efficacy and safety of "RV2427B" cream in Irritant dermatitis care. ( 23984228 )
2013
9
IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. ( 22966985 )
2013
10
Oxidative stress in allergic and irritant dermatitis: from basic research to clinical management. ( 22827837 )
2012
11
Allergic and irritant dermatitis: pathogenic and management aspects. ( 22827836 )
2012
12
Hand hygiene compliance and irritant dermatitis: a juxtaposition of healthcare issues. ( 22691060 )
2012
13
Contact irritant dermatitis in Kenya. ( 23472569 )
2012
14
Irritant Dermatitis to Staphylinid Beetle in Indian Troops in Congo. ( 27375320 )
2010
15
IL-6, VEGF, KC and RANTES are a major cause of a high irritant dermatitis to phthalic anhydride in C57BL/6 inbred mice. ( 20864798 )
2010
16
Povidone iodine irritant dermatitis. ( 20606840 )
2010
17
WOC nurse consult: Moist, painful peristomal skin. Chemical irritant dermatitis and pseudoverrucous lesions. ( 20228658 )
2010
18
Hair highlights and severe acute irritant dermatitis ("burn") of the scalp. ( 20854194 )
2010
19
Recurrent cyclic hyperkeratotic eczema after occupational alkali burn: traumatic chronic irritant dermatitis. ( 19489972 )
2009
20
Contact irritant dermatitis from insect secretions: report of 74 cases in a military unit in Eritrea. ( 19731793 )
2009
21
Treatment with pimecrolimus cream 1% clears irritant dermatitis of the periocular region, face and neck. ( 18937664 )
2008
22
The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. ( 18537995 )
2008
23
Contact and primary irritant dermatitis of the nail unit diagnosis and treatment. ( 17403259 )
2007
24
Occlusive irritant dermatitis: when is "allergic" contact dermatitis not allergic? ( 17366682 )
2007
25
Moisturizer effect on irritant dermatitis: an overview. ( 16930228 )
2006
26
Effectiveness of a hand care regimen with moisturizer in manufacturing facilities where workers are prone to occupational irritant dermatitis. ( 15573643 )
2004
27
Irritant dermatitis to detergents in textiles. ( 12882025 )
2003
28
Irritant dermatitis due to prolonged contact with Oilatum Plus. ( 12534617 )
2003
29
Contact irritant dermatitis and anti-pruritic agents: the need to address the itch. ( 12852365 )
2003
30
Irritant dermatitis, irritancy and its role in allergic contact dermatitis. ( 11952708 )
2002
31
Sea water or its components alter experimental irritant dermatitis in man. ( 11301639 )
2001
32
Successfully managing incontinence-related irritant dermatitis across the lifespan. ( 10347509 )
1999
33
Crystal deodorant dermatitis: irritant dermatitis to alum-containing deodorant. ( 10431678 )
1999
34
Arachidonic acid metabolism in primary irritant dermatitis produced by patch testing of human skin with surfactants. ( 9875300 )
1998
35
Human barrier recovery after acute acetone perturbation: an irritant dermatitis model. ( 9667101 )
1998
36
Kerosene - Induced Acute Irritant Dermatitis (le). ( 20921732 )
1998
37
Open application assay in investigation of subclinical irritant dermatitis induced by sodium lauryl sulfate (SLS) in man: advantage of squamometry. ( 27332695 )
1998
38
Predictive testing in contact dermatitis. Irritant dermatitis. ( 9255475 )
1997
39
What's new in irritant dermatitis. ( 9255463 )
1997
40
Pigmented and hyperkeratotic napkin dermatitis: a liquid detergent irritant dermatitis. ( 8864616 )
1996
41
Sodium hydroxide-induced irritant dermatitis as assessed by computerized elaboration of 20 MHz B-scan images and by TEWL measurement: a method for investigating skin barrier function. ( 7604663 )
1995
42
Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate. ( 7772476 )
1995
43
Acute irritant dermatitis: effect of short-term topical corticoid treatment. ( 7587340 )
1995
44
Irritant dermatitis among workers cleaning up a pesticide spill: California 1991. ( 7793424 )
1995
45
Irritant dermatitis: experimental aspects. ( 9035907 )
1995
46
Irritant dermatitis in the workplace. ( 7923942 )
1994
47
The causes of irritant dermatitis. ( 8240913 )
1993
48
Moisturizers prevent irritant dermatitis. ( 1350143 )
1992
49
Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. ( 1681644 )
1991
50
Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. ( 2365862 )
1990

Variations for Irritant Dermatitis

Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 IL1A IL1B MS4A2 TNF
2
Show member pathways
12.19 FLG KRT16 LCE2B PI3
3
Show member pathways
12.06 IL1A IL1B TNF
4 12.03 IL1A IL1B TNF
5
Show member pathways
12.01 IL1A IL1B TNF
6
Show member pathways
12 IL1A IL1B TNF
7 11.96 IL1A IL1B TNF
8 11.88 IL1A IL1B TNF
9 11.82 IL1A IL1B TNF
10 11.78 IL1A IL1B TNF
11 11.74 IL1A IL1B TNF
12 11.67 IL1A IL1B TNF
13 11.64 IL1A IL1B TNF
14 11.59 IL1A IL1B TNF
15 11.46 IL1A IL1B TNF
16
Show member pathways
11.3 IL1A IL1B TNF
17 11.18 IL1B TNF
18 11.18 IL1A IL1B
19 11.13 IL1B TNF
20 11.12 IL1A IL1B TNF
21 11.11 IL1B TNF
22 11.01 IL1A IL1B TNF
23 10.99 IL1A IL1B TNF
24 10.91 IL1B TNF
25 10.75 IL1B TNF
26 10.68 IL1A IL1B TNF
27 10.26 IL1A IL1B TNF
28 10.21 IL1A IL1B

GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.8 FLG LCE2B PI3

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 IL1A IL1B MS4A2 TNF
2 cornification GO:0070268 9.71 FLG KRT16 PI3
3 keratinocyte differentiation GO:0030216 9.69 FLG KRT16 LCE2B
4 positive regulation of phagocytosis GO:0050766 9.65 IL1B TNF
5 protein kinase B signaling GO:0043491 9.65 IL1B TNF
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B TNF
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.64 IL1A IL1B
8 positive regulation of cytokine secretion GO:0050715 9.64 IL1A TNF
9 positive regulation of interleukin-8 production GO:0032757 9.63 IL1B TNF
10 positive regulation of mitotic nuclear division GO:0045840 9.63 IL1A IL1B
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.62 IL1A IL1B
12 negative regulation of neurogenesis GO:0050768 9.62 IL1B TNF
13 positive regulation of interleukin-6 secretion GO:2000778 9.61 IL1B NLRP10
14 establishment of skin barrier GO:0061436 9.6 FLG KRT16
15 negative regulation of lipid catabolic process GO:0050995 9.59 IL1B TNF
16 positive regulation of glial cell proliferation GO:0060252 9.58 IL1B TNF
17 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
18 peptide cross-linking GO:0018149 9.58 FLG LCE2B PI3
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IL1B TNF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL1B TNF
21 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.55 IL1A IL1B
22 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IL1B TNF
23 ectopic germ cell programmed cell death GO:0035234 9.49 IL1A IL1B
24 regulation of establishment of endothelial barrier GO:1903140 9.48 IL1B TNF
25 positive regulation of neuroinflammatory response GO:0150078 9.46 IL1B TNF
26 positive regulation of fever generation GO:0031622 9.43 IL1B TNF
27 chronic inflammatory response to antigenic stimulus GO:0002439 9.37 IL1B TNF
28 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
29 fever generation GO:0001660 9.26 IL1A IL1B
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
31 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.13 IL1A IL1B TNF
32 inflammatory response GO:0006954 9.1 IL1A IL1B KRT16 MS4A2 NLRP10 TNF

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.43 FLG KRT16 LCE2B
2 cytokine activity GO:0005125 9.33 IL1A IL1B TNF
3 structural constituent of epidermis GO:0030280 8.96 FLG PI3
4 interleukin-1 receptor binding GO:0005149 8.62 IL1A IL1B

Sources for Irritant Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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