Irritant Dermatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary : Irritant Dermatitis, also known as dermatitis, irritant, is related to skin conditions and erysipelas. An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Allograft rejection and Keratinization. The drugs Glycerol and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver.

Wikipedia : ⁷⁶ Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

Sources

Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)

#	Related Disease	Score	Top Affiliating Genes
1	skin conditions	30.3	IL1A TNF
2	erysipelas	30.1	PI3 TNF
3	allergic contact dermatitis	30.1	FLG IL1B TNF
4	dermatitis, atopic	30.0	FLG MS4A2 TNF
5	contact dermatitis	29.9	FLG IL1A IL1B KRT16 TNF
6	skin disease	29.8	FLG IL1A KRT16 PI3 TNF
7	psoriasis	29.4	FLG IL1A IL1B KRT16 PI3 TNF
8	dermatitis	10.8
9	chronic follicular conjunctivitis	10.2	IL1A IL1B
10	discoid lupus erythematosus	10.2	FLG KRT16
11	esophagitis, eosinophilic, 1	10.2	FLG IER3IP1
12	dysentery	10.2	IER3IP1 IL1A
13	limbal stem cell deficiency	10.2	IL1A IL1B
14	chronic graft versus host disease	10.2	IL1A TNF
15	meningococcemia	10.2	IL1A IL1B
16	melancholia	10.2	IER3IP1 TNF
17	post-transplant lymphoproliferative disease	10.2	IL1A TNF
18	gingival disease	10.2	IL1A IL1B
19	multidrug-resistant tuberculosis	10.2	IL1A TNF
20	exudative glomerulonephritis	10.2	IL1B TNF
21	orofacial granulomatosis	10.2	FLG TNF
22	staphylococcal toxic shock syndrome	10.2	IL1B TNF
23	kashin-beck disease	10.1	IL1B TNF
24	rheumatoid lung disease	10.1	IL1B TNF
25	vulvar vestibulitis syndrome	10.1	IL1B TNF
26	lichen disease	10.1	FLG TNF
27	burns	10.1	IL1B TNF
28	glossitis	10.1	IL1B TNF
29	laryngitis	10.1	IL1B TNF
30	haemophilus influenzae	10.1	IL1B TNF
31	opisthorchiasis	10.1	IL1B TNF
32	erythema multiforme	10.1
33	retinitis pigmentosa 60	10.1	IL1B TNF
34	acute vascular insufficiency of intestine	10.1	IL1B TNF
35	congenital cytomegalovirus	10.1	IL1B TNF
36	actinic prurigo	10.1	IL1B TNF
37	osteosclerotic myeloma	10.1	IL1B TNF
38	root resorption	10.1	IL1A IL1B
39	palmoplantar keratoderma, epidermolytic	10.1	FLG KRT16
40	crohn's colitis	10.1	IL1B TNF
41	poems syndrome	10.1	IL1B TNF
42	periapical periodontitis	10.1	IL1B TNF
43	cholesteatoma of middle ear	10.1	FLG IL1A KRT16
44	central nervous system vasculitis	10.1	IL1B TNF
45	jejunoileitis	10.1	IL1B TNF
46	endometrial disease	10.1	IL1B TNF
47	rosacea	10.1	IER3IP1 TNF
48	dental pulp disease	10.1	IL1B TNF
49	primary systemic mycosis	10.1	IL1B TNF
50	eales disease	10.1	IL1B TNF

Graphical network of the top 20 diseases related to Irritant Dermatitis:

Sources

Symptoms & Phenotypes for Irritant Dermatitis

Sources

Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Glycerol

Approved, Investigational

Phase 4

56-81-5

753

Synonyms:

1,2,3-propanetriol

1,2,3-Propanetriol

1,2,3-trihydroxypropane

1,2,3-Trihydroxypropane

Bulbold

Cristal

e 422

Emery 916

Glyceol opthalgan

Glycerin

Glycerin, anhydrous

Glycerin,anhydrous

Glycerine

glycérine

Glycerinum

Glyceritol

Glycerol

glycérol

Glycerolum

Glycyl alcohol

Glyrol

Glysanin

Glyzerin

Gro

IFP

Incorporation factor

Mackstat H 66

Monoctanoin component D

Oelsuess

Ölsüß

Osmoglyn

Pricerine 9091

Propanetriol

RG-S

Trihydroxypropane

Tryhydroxypropane

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492

Synonyms:

(-)-FK 506

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone

104987-11-3

109581-93-3 (Hydrate)

15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,

3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN

AC-1182

AC1L1K7H

AC1L97GB

AC1L9IBU

Advagraf

AKOS005145901

Ambap104987-11-3

Ambap5429

Anhydrous tacrolimus

Anhydrous, tacrolimus

BCBcMAP01_000194

Bio-0921

Bio2_000470

Bio2_000950

BRD-K35452788-001-02-1

BSPBio_001279

BSPBio-001279

C01375

C44H69NO10

CCRIS 7124

CHEBI:100924

CHEBI:61049

CHEMBL1200738

CID11158639

CID11556866

CID439492

CID445643

CID5372

CID5472317

CID6426916

CID6436007

CID6473866

CID6536850

CID6610362

CID6912836

CID9832283

CID9853905

CID9918805

CID9940643

CID9963169

Cilag brand OF tacrolimus

CPD000466356

CPD-10016

D08556

DB00864

DivK1c_001040

FK 506

FK5

Fk-506

FK506

FK-506

FR 900506

FR900506

FR-900506

FT-0082660

Fujimycin

Fujisawa brand OF tacrolimus

Graceptor

HMS1362O21

HMS1792O21

HMS1990O21

HMS2051C18

HMS2093M19

HMS503O21

IDI1_001040

IDI1_002225

Janssen brand OF tacrolimus

K506

KBio1_001040

KBio2_000619

KBio2_003187

KBio2_005755

KBio3_001097

KBio3_001098

KBioGR_000619

KBioSS_000619

L 679934

L-679934

LCP-Tacro

LMPK04000003

LS-64247

MLS000759471

MLS001424054

Modigraf

MolPort-003-666-518

NCGC00163470-01

NCGC00163470-02

NCGC00163470-03

NCGC00163470-04

NCGC00179232-01

NChemBio.2007.16-comp1

nchembio.2007.23-comp2

NINDS_001040

NSC717865

Prograf

Prograf (TN)

Prograft

Protopic

Protopy

S5003_Selleck

SAM001246677

SMR000466356

Tacarolimus

tacrolimus

Tacrolimus (anhydrous)

Tacrolimus (INN)

Tacrolimus (Prograf?)

Tacrolimus anhydrous

tacrolimus hydrate

Tacrolimus, anhydrous

Tsukubaenolide

UNII-Y5L2157C4J

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 2

124-94-7

31307

Synonyms:

(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11b,16a,17a,21-Tetrahydroxy-9a-fluoro-1,4-pregnadiene-3,20-dione

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione

11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione

11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

124-94-7

4-08-00-03629 (Beilstein Handbook Reference)

83474-03-7

9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d

9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone

9a-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-16a-Hydroxyprednisolone

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9alpha-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-11beta,16alpha,17alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-16alpha-Hydroxyprednisolone

9alpha-Fluoro-16alpha-hydroxyprednisolone

9-alpha-Fluoro-16-alpha-hydroxyprednisolone

9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-16α-hydroxyprednisolone

AC1L1LDH

AC1Q5HJC

AC-2072

Adcortyl

Aristocort

Aristocort A

Aristocort Tablets

Aristogel

Aristospan

Azmacort

Bio-0662

BPBio1_000154

BRD-K77554836-001-03-3

BRN 2341955

BSPBio_000140

C21H27FO6

Celeste

CHEMBL1451

CID31307

Cinolone

Cinolone-T

CL 19823

D00385

D014221

DB00620

Delphicort

droxypregna-1,4-diene-3,20-dione

EINECS 204-718-7

EU-0101179

Fluoxiprednisolone

Fluoxyprednisolone

Flutex

Fougera

HMS1568G22

HMS2090D12

HSDB 3194

ione

Kenacort

Kenacort (TN)

Kenacort-A

Kenacort-Ag

Kenacort-AG

Kenalog

Kenalog in Orabase

Kenalog-10

Kenalog-40

Kenalog-H

Ledercort

Lopac0_001179

LS-698

MLS000028542

MLS001066543

MLS002695935

MolPort-002-528-981

Mycolog

Nasacort

Nasacort Aq

Nasacort Hfa

NCGC00021580-03

NCGC00021580-04

NCGC00021580-05

NCGC00021580-06

NCGC00021580-07

nchembio.2007.53-comp7

NCI60_000750

NSC 13397

NSC13397

Omcilon

Omicilon

Oracort

Oralone

Orion

Polcortolon

Pregna-1,4-diene-3,20-dio

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)

Prestwick_438

Prestwick0_000120

Prestwick1_000120

Prestwick2_000120

Prestwick3_000120

Rodinolone

S1933_Selleck

Sk-Triamcinolone

SK-Triamcinolone

SMP1_000300

SMR000058333

SPBio_002079

T6376_SIGMA

Tiamcinolonum

Tiamcinolonum [INN-Latin]

Triacet

Triacort

Triamcet

Triamcinalone

Triamcinlon

Triamcinolon

Triamcinolona

Triamcinolona [INN-Spanish]

triamcinolone

Triamcinolone (JP15/USP/INN)

TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))

Triamcinolone [USAN:INN:BAN:JAN]

Triamcinolone acetonide

Triamcinolone diacetate

Triamcinolone hexacetonide

Triamcinolonum

Triamcinolonum [INN]

Triam-Tablinen

Triatex

Tricortale

Triderm

Trilone

Tri-Nasal

Tristoject

Trymex

UNII-1ZK20VI6TY

Vetalog

Volon

Volon A

WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ

ZINC03882036

Mineral oil

Approved, Vet_approved

Phase 4

8042-47-5

Synonyms:

Food Grade Mineral Oil

Heavy Liquid Petrolatum

Heavy mineral oil

Liquid Paraffin

Liquid Petrolatum

Mineral Oil (high Viscosity)

Mineral Oil, Heavy

Paraffin Oil

Paraffin, Liquid

Paraffinum Liquidum

Petrolatum, Liquid

White Mineral Oil

Clobetasol

Approved, Experimental, Investigational

Phase 4

25122-46-7, 25122-41-2

5311051 32798

Synonyms:

(11b,16b)-21-chloro-9-fluoro-11,17-Dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11beta,16beta)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11beta,16beta)-21-chloro-9-fluoro-11,17-Dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11β,16β)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

(9R,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione

21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate

25122-41-2

AC-1775

AC1L1OG6

AC1NDRJ9

AC1NSJWK

BB_NC-1906

C22H28ClFO4

CHEBI:205919

CHEMBL1201362

CID10341542

CID32797

CID4630419

CID5311051

CID9844480

Clobecort Amex

Clobecort Amex (TN)

clobetasol

Clobetasol (INN)

Clobetasol [INN:BAN]

Clobetasol 17 propionate

clobetasol 17-propanoate

clobetasol 17-propionate

Clobetasol 17-propionate

Clobetasol propionate

Clobetasol propionate E

Clobetasolum

Clobetasolum [INN-Latin]

Clobex

Clofenazon

Cormax

D07715

Dermovate

EINECS 246-633-8

Embeline

Embeline e

LS-174086

MolPort-005-909-335

NCGC00164580-01

OLUX

STK801976

Temovate

UNII-ADN79D536H

ZINC26892643

triamcinolone acetonide

Phase 4,Phase 2

Hormones

Phase 4,Phase 2

Triamcinolone diacetate

Phase 4,Phase 2

Calcineurin Inhibitors

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2

Immunosuppressive Agents

Phase 4,Phase 2

Dermatologic Agents

Phase 4,Not Applicable

glucocorticoids

Phase 4,Phase 2

Triamcinolone hexacetonide

Phase 4,Phase 2

Emollients

Phase 4,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 2

Hormone Antagonists

Phase 4,Phase 2

Immunologic Factors

Phase 4,Phase 2

Protective Agents

Phase 4

Timolol

Approved

Phase 3

26839-75-8

33624 5478

Synonyms:

(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole

(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol

(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol

(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol

(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol

(S)-timolol

131628-37-0

194288-09-0

26839-75-8

26921-17-5 (maleate (1:1) salt)

AB00513729

AC1L1PYN

AC1Q59QM

Apo-Timol

Apo-Timop

Aquanil

Betim

Betimol

Betimol (TN)

BIDD:GT0073

Blocadren

BPBio1_001008

BRD-K08806317-050-03-6

BSPBio_000916

C07141

C13H24N4O3S

CAS-26921-17-5

CHEBI:9599

CHEMBL499

CID33624

CPD001456519

D08600

DB00373

DB08625

EINECS 248-032-6

HMS2089I11

HSDB 6533

Istalol

L-714,465

Lopac0_001189

Lopac-T-6394

LS-122231

MK-950

NCGC00016038-01

NCGC00016038-02

NCGC00016798-01

NCGC00016798-07

NCGC00022033-02

NCGC00022033-04

NCGC00022033-05

Novo-Timol

Nu-Timolol

Oprea1_640981

Optimol

Phoxal-timolol

Prestwick0_000948

Prestwick1_000948

Prestwick2_000948

Prestwick3_000948

Proflax

S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole

S(-)-Timolol maleate

SAM002564238

SPBio_003075

ST072193

Temserin

Tenopt

TIM

Timacar

Timacor

Tim-AK

timolol

Timolol

Timolol (INN)

Timolol (TN)

Timolol [USAN]

Timolol anhydrous

Timolol GFS

Timolol maleate

Timolol Maleate, (1:1) Salt

Timololo

Timololum

Timololum [INN-Latin]

Timopic

Timoptic

Timoptic in Ocudose

Timoptic OcuDose

Timoptic-XE

Timoptol

Tocris-0649

UNII-817W3C6175

Maleic acid

Experimental

Phase 3

110-16-7

444266

Synonyms:

(2E)-2-Butenedioate

(2E)-2-Butenedioic acid

(2E)-But-2-enedioate

(2E)-But-2-enedioic acid

(e)-2-Butenedioate

(e)-2-Butenedioic acid

2-(e)-Butenedioate

2-(e)-Butenedioic acid

Allomaleate

Allomaleic acid

Ammonium fumarate

Boletate

Boletic acid

e297

FC 33

Fumarate

Fumarsaeure

Furamag

Lichenate

Lichenic acid

Magnesium fumarate

Sodium fumarate

trans-1,2-Ethylenedicarboxylate

trans-1,2-Ethylenedicarboxylic acid

trans-2-Butenedioate

trans-2-Butenedioic acid

trans-But-2-enedioate

trans-But-2-enedioic acid

trans-Butenedioate

trans-Butenedioic acid

Ophthalmic Solutions

Phase 3

Neurotransmitter Agents

Phase 3

Antihypertensive Agents

Phase 3

Adrenergic Antagonists

Phase 3

Adrenergic beta-Antagonists

Phase 3

Pharmaceutical Solutions

Phase 3

Adrenergic Agents

Phase 3

Anti-Arrhythmia Agents

Phase 3

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Synonyms:

.Beta.,.beta.'-Dichlorodiethyl-N-methylamine

1, 5-Dichloro-3-methyl-3-azapentane hydrochloride

126-85-2 (N-oxide)

2,2'-Dichlorodiethyl-methylamine

2,2'-Dichloro-N-me

2,2'-dichloro-N-methyldiethylamine

2,2'-dichloro-N-Methyldiethylamine

2,2'-Dichloro-N-methyldiethylamine

2-Chloro-N-(2-chloroethyl)-N-methylethanamine

302-70-5 (N-oxide, hydrochloride)

51-75-2

55-86-7 (HYDROCHLORIDE)

AC1L1H9H

Antimit

b,Beta'-dichlorodiethyl-N-methylamine

beta,beta'-Dichlorodiethyl-N-methylamine

beta,Beta'-dichlorodiethyl-N-methylamine

Bis(2-chloroethyl)methylamine

Bis(b-chloroethyl)methylamine

Bis(beta-chloroethyl) methylamine

Bis(beta-chloroethyl)methylamine

Bis(β-chloroethyl)methylamine

BRN 0605323

BSPBio_001947

C07115

C5H11Cl2N

Carolysine

Caryolysin

Caryolysine

CCRIS 447

CHEBI:28925

CHEMBL427

Chloramine (the nitrogen mustard)

Chlorethazine

Chlormethine

Chlormethine (INN)

Chlormethine [INN:BAN]

Chlormethinum [INN-Latin]

CID4033

Cloramin

Clormetina

Clormetina [INN-Spanish]

D07671

DB00888

Di(2-chloroethyl)methylamine

Dichlor amine

Dichloren

DivK1c_000759

EINECS 200-120-5

Embechine

Embichin

ENT-25294

HMS1920J15

HMS2091B04

HMS502F21

HN2

HN-2

HSDB 5083

Hydrochloride N-oxide, mechlorethamine

Hydrochloride, mechlorethamine

I14-8708

IBS-L0033631

IDI1_000759

KBio1_000759

KBio2_001369

KBio2_003937

KBio2_006505

KBio3_001447

KBioGR_001448

KBioSS_001369

LS-7559

MBA

Me chloroethamine

Mebichloramine

mechlorethamine

Mechlorethamine

Mechlorethamine hydrochloride

Mechlorethamine hydrochloride N oxide

Mechlorethamine hydrochloride N-oxide

Mechlorethamine N oxide

Mechlorethamine N-oxide

Mechlorethamine oxide

Mechlorethanamine

Mechloroethamine

Mecloretamina

Mecloretamina [Italian]

Merck brand OF mechlorethamine hydrochloride

Merck frosst brand OF mechlorethamine hydrochloride

Methylbis(2-chloroethyl)amine

Methylbis(b-chloroethyl)amine

Methylbis(beta-chloroethyl)amine

Methylbis(β-chloroethyl)amine

Methylchlorethamine

Methyldi(2-chloroethyl)amine

Mitomen

Mitoxine (*Hydrochloride*)

MolPort-001-785-592

Mustargen

Mustine

Mustine note

Mutagen

N,N-Bis(2-chloroethyl)methylamine

N,N-Bis(2-chloroethyl)-N-methylamine

N,N-Di(chloroethyl)methylamine

NCGC00091835-02

NCGC00091835-03

NCGC00091835-04

NCGC00091835-05

NCI60_041682

NINDS_000759

Nitol (*Hydrochloride*)

Nitrogen mustard

Nitrogen mustard (HN-2)

Nitrogen mustard N oxide

Nitrogen mustard N-oxide

Nitrogranulogen

Nitromin

N-Lost

N-Methyl lost

N-Methyl-2,2'-dichlorodiethylamine

N-methyl-bis(2-chloroethyl)amine

N-Methyl-bis(2-chloroethyl)amine

N-Methyl-bis(b-chloroethyl)amine

N-Methyl-bis(beta-chloroethyl)amine

N-Methyl-bis(β-chloroethyl)amine

N-Methyl-bis-chloraethylamin

N-Methyl-bis-chloraethylamin [German]

N-Methyl-lost

N-Methyl-lost [German]

N-Oxide, mechlorethamine hydrochloride

N-Oxide, nitrogen mustard

NSC 762

NSC762

NSC-762

SPBio_000496

Spectrum_000889

SPECTRUM1500375

Spectrum2_000448

Spectrum3_000484

Spectrum4_000924

Spectrum5_001702

Stickstofflost (*Hydrochloride*)

Stickstofflost (ebewe)

T 1024

T-1024

thyldiethylamine

TL 146

UNII-50D9XSG0VR

β,beta'-dichlorodiethyl-N-methylamine

β,β'-dichlorodiethyl-N-methylamine

Antineoplastic Agents, Alkylating

Phase 2

Alkylating Agents

Phase 2

Nitrogen Mustard Compounds

Phase 2

Anesthetics

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation	Unknown status	NCT00779792	Phase 4	clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
2	Topical Timolol for Superficial Infantile Hemangioma	Unknown status	NCT01685398	Phase 3	0.5% timolol maleate eye drop;Normal saline
3	Mechlorethamine Induced Contact Dermatitis Avoidance Study	Recruiting	NCT03380026	Phase 2	Triamcinolone;Valchlor 0.016 % Topical Gel
4	A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema	Unknown status	NCT01012453	Not Applicable
5	Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery	Completed	NCT03231813	Not Applicable
6	Effect of Tetrix on Alleviation of Burning,Itching Associated With Lesions of Contact Dermatitis	Completed	NCT00646867	Not Applicable
7	Risk Factors for Incontinence-Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence	Completed	NCT02996357
8	Prospective Single Center Randomized Double Blind Controlled Tolerability Trial of Six Hair Cleansing Conditioners	Recruiting	NCT03483025	Not Applicable
9	Histopathological Comparison Between Superficial Pressure Ulcers and Incontinence-associated Dermatitis	Not yet recruiting	NCT03685929
10	Preliminary Evaluation of CASTLE Barrier Prototype UK	Terminated	NCT01530087	Not Applicable
11	Comparison of Wash Wipes and Standard Care in the Prevention of Incontinence-associated Dermatitis in Elderly	Terminated	NCT02475512	Not Applicable
12	Vulvar Contact Dermatitis Resulting From Urine Incontinence	Withdrawn	NCT01320046

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

Sources

Genetic Tests for Irritant Dermatitis

Sources

Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

⁴¹

Skin, Lung, Liver, Bone, Lymph Node, Tonsil, Prostate

Sources

Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 80)

#	Title	Authors	Year
1	Immediate irritant dermatitis from the passionvine hopper (Scolypopa australis). ( 29869388 )		2018
2	Histomorphology and Immunophenotype of Eczematous Skin Lesions Revisited-Skin Biopsies Are Not Reliable in Differentiating Allergic Contact Dermatitis, Irritant Contact Dermatitis, and Atopic Dermatitis. ( 28296664 )	Frings VG...Breuer K	2018
3	Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. ( 30145688 )	Adami M...Stark H	2018
4	Non-glaucoma periocular allergic, atopic, and irritant dermatitis at an academic institution: A retrospective review. ( 29985741 )	Pandit SA...Glass LRD	2018
5	Preapplication of white petroleum jelly to adjacent skin to prevent aluminum chloride-induced irritant dermatitis. ( 28619576 )	Oliver B....Aires D.	2017
6	Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis. ( 28774591 )	Dai J....Fisher D.E.	2017
7	N-acyl ethanolamide and eicosanoid involvement in irritant dermatitis. ( 26947140 )		2016
8	To evaluate the efficacy and safety of &quot;RV2427B&quot; cream in Irritant dermatitis care. ( 23984228 )	Bhat R.M....Ribet V.	2013
9	IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. ( 22966985 )	Lee E.G....Gallucci R.M.	2013
10	Oxidative stress in allergic and irritant dermatitis: from basic research to clinical management. ( 22827837 )	Nakai K....Kubota Y.	2012
11	Allergic and irritant dermatitis: pathogenic and management aspects. ( 22827836 )	Marrakchi S.	2012
12	Hand hygiene compliance and irritant dermatitis: a juxtaposition of healthcare issues. ( 22691060 )	Visscher M.O....Randall Wickett R.	2012
13	Contact irritant dermatitis in Kenya. ( 23472569 )		2012
14	Irritant Dermatitis to Staphylinid Beetle in Indian Troops in Congo. ( 27375320 )	Vasudevan B....Joshi D.C.	2010
15	IL-6, VEGF, KC and RANTES are a major cause of a high irritant dermatitis to phthalic anhydride in C57BL/6 inbred mice. ( 20864798 )	Bae C.J....Hwang D.Y.	2010
16	Povidone iodine irritant dermatitis. ( 20606840 )		2010
17	WOC nurse consult: Moist, painful peristomal skin. Chemical irritant dermatitis and pseudoverrucous lesions. ( 20228658 )		2010
18	Hair highlights and severe acute irritant dermatitis (&quot;burn&quot;) of the scalp. ( 20854194 )		2010
19	Recurrent cyclic hyperkeratotic eczema after occupational alkali burn: traumatic chronic irritant dermatitis. ( 19489972 )	Nielsen T.K....Kolstad H.A.	2009
20	Contact irritant dermatitis from insect secretions: report of 74 cases in a military unit in Eritrea. ( 19731793 )	Smadi R.M....Ka'abneh A.	2009
21	Treatment with pimecrolimus cream 1% clears irritant dermatitis of the periocular region, face and neck. ( 18937664 )	Mensing C.O....Mensing H.	2008
22	The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. ( 18537995 )	Ortiz P.G....Benfeldt E.	2008
23	Contact and primary irritant dermatitis of the nail unit diagnosis and treatment. ( 17403259 )	Militello G.	2007
24	Occlusive irritant dermatitis: when is &quot;allergic&quot; contact dermatitis not allergic? ( 17366682 )		2007
25	Moisturizer effect on irritant dermatitis: an overview. ( 16930228 )	Yokota M...Maibach HI	2006
26	Effectiveness of a hand care regimen with moisturizer in manufacturing facilities where workers are prone to occupational irritant dermatitis. ( 15573643 )	Arbogast J.W....Maibach H.I.	2004
27	Irritant dermatitis to detergents in textiles. ( 12882025 )	Matthies W.	2003
28	Irritant dermatitis due to prolonged contact with Oilatum Plus. ( 12534617 )	Loo W.J.	2003
29	Contact irritant dermatitis and anti-pruritic agents: the need to address the itch. ( 12852365 )	Burkhart C.G....Burkhart H.R.	2003
30	Irritant dermatitis, irritancy and its role in allergic contact dermatitis. ( 11952708 )		2002
31	Sea water or its components alter experimental irritant dermatitis in man. ( 11301639 )	Yoshizawa Y....Maibach H.I.	2001
32	Successfully managing incontinence-related irritant dermatitis across the lifespan. ( 10347509 )	Scardillo J....Aronovitch S.A.	1999
33	Crystal deodorant dermatitis: irritant dermatitis to alum-containing deodorant. ( 10431678 )		1999
34	Arachidonic acid metabolism in primary irritant dermatitis produced by patch testing of human skin with surfactants. ( 9875300 )		1998
35	Human barrier recovery after acute acetone perturbation: an irritant dermatitis model. ( 9667101 )		1998
36	Kerosene - Induced Acute Irritant Dermatitis (le). ( 20921732 )		1998
37	Open application assay in investigation of subclinical irritant dermatitis induced by sodium lauryl sulfate (SLS) in man: advantage of squamometry. ( 27332695 )	Charbonnier V...Maibach HI	1998
38	Predictive testing in contact dermatitis. Irritant dermatitis. ( 9255475 )	Basketter D.A....York M.	1997
39	What's new in irritant dermatitis. ( 9255463 )	Berardesca E	1997
40	Pigmented and hyperkeratotic napkin dermatitis: a liquid detergent irritant dermatitis. ( 8864616 )	Patrizi A....Fiorillo L.	1996
41	Sodium hydroxide-induced irritant dermatitis as assessed by computerized elaboration of 20 MHz B-scan images and by TEWL measurement: a method for investigating skin barrier function. ( 7604663 )	Seidenari S....Di Nardo A.	1995
42	Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate. ( 7772476 )	Nicander I....Emtestam L.	1995
43	Acute irritant dermatitis: effect of short-term topical corticoid treatment. ( 7587340 )	Berardesca E....Rabbiosi G.	1995
44	Irritant dermatitis among workers cleaning up a pesticide spill: California 1991. ( 7793424 )		1995
45	Irritant dermatitis: experimental aspects. ( 9035907 )		1995
46	Irritant dermatitis in the workplace. ( 7923942 )		1994
47	The causes of irritant dermatitis. ( 8240913 )	Fleming M.G.	1993
48	Moisturizers prevent irritant dermatitis. ( 1350143 )	Hannuksela A....Kinnunen T.	1992
49	Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. ( 1681644 )	Agner T.	1991
50	Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. ( 2365862 )	Wilhelm K.P....Maibach H.I.	1990

Sources

Genes for Irritant Dermatitis

Genes related to Irritant Dermatitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IL1A	Interleukin 1 Alpha	Protein Coding	22.28	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	IER3IP1	Immediate Early Response 3 Interacting Protein 1	Protein Coding	17.29	DISEASES inferred ¹⁵ ¹⁵
3	FLG	Filaggrin	Protein Coding	16.58	DISEASES inferred ¹⁵
4	KRT16	Keratin 16	Protein Coding	15.73	DISEASES inferred ¹⁵
5	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	15.48	DISEASES inferred ¹⁵
6	IL1B	Interleukin 1 Beta	Protein Coding	14.97	DISEASES inferred ¹⁵
7	TNF	Tumor Necrosis Factor	Protein Coding	14.92	DISEASES inferred ¹⁵
8	NLRP10	NLR Family Pyrin Domain Containing 10	Protein Coding	14.8	DISEASES inferred ¹⁵
9	PI3	Peptidase Inhibitor 3	Protein Coding	14.74	DISEASES inferred ¹⁵
10	LCE2B	Late Cornified Envelope 2B	Protein Coding	6.37	DISEASES inferred ¹⁵
11	OR2B3	Olfactory Receptor Family 2 Subfamily B Member 3	Protein Coding	6.19	DISEASES inferred ¹⁵

Sources

Variations for Irritant Dermatitis

Sources

Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

Sources

Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 28)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.67	IL1A IL1B MS4A2 TNF
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.19	FLG KRT16 LCE2B PI3
3	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.06	IL1A IL1B TNF
4	Tuberculosis ³⁷	12.03	IL1A IL1B TNF
5	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.01	IL1A IL1B TNF
6	Necroptosis ³⁷ Show member pathways Nanoparticle triggered regulated necrosis ¹	12	IL1A IL1B TNF
7	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.96	IL1A IL1B TNF
8	Fluid shear stress and atherosclerosis ³⁷	11.88	IL1A IL1B TNF
9	Osteoclast differentiation ³⁷	11.82	IL1A IL1B TNF
10	Spinal Cord Injury ¹	11.78	IL1A IL1B TNF
11	Interleukin-4 and 13 signaling ⁶⁶	11.74	IL1A IL1B TNF
12	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.67	IL1A IL1B TNF
13	Hematopoietic cell lineage ³⁷	11.64	IL1A IL1B TNF
14	Rheumatoid arthritis ³⁷	11.59	IL1A IL1B TNF
15	Pertussis ³⁷	11.46	IL1A IL1B TNF
16	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.3	IL1A IL1B TNF
17	African trypanosomiasis ³⁷	11.18	IL1B TNF
18	Prion diseases ³⁷	11.18	IL1A IL1B
19	Development and heterogeneity of the ILC family ¹	11.13	IL1B TNF
20	Interleukin-10 signaling ⁶⁶	11.12	IL1A IL1B TNF
21	Antifolate resistance ³⁷	11.11	IL1B TNF
22	G-protein signaling_RhoB regulation pathway ²²	11.01	IL1A IL1B TNF
23	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.99	IL1A IL1B TNF
24	Cellular roles of Anthrax toxin ¹	10.91	IL1B TNF
25	LDL Oxidation in Atherogenesis ⁶⁴	10.75	IL1B TNF
26	IL-10 Pathway ⁶⁴	10.68	IL1A IL1B TNF
27	Cytokines and Inflammatory Response ¹	10.26	IL1A IL1B TNF
28	Interleukin-1 processing ⁶⁶	10.21	IL1A IL1B

Sources

GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cornified envelope	GO:0001533	8.8	FLG LCE2B PI3

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 32)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.91	IL1A IL1B MS4A2 TNF
2	cornification	GO:0070268	9.71	FLG KRT16 PI3
3	keratinocyte differentiation	GO:0030216	9.69	FLG KRT16 LCE2B
4	positive regulation of phagocytosis	GO:0050766	9.65	IL1B TNF
5	protein kinase B signaling	GO:0043491	9.65	IL1B TNF
6	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.65	IL1B TNF
7	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.64	IL1A IL1B
8	positive regulation of cytokine secretion	GO:0050715	9.64	IL1A TNF
9	positive regulation of interleukin-8 production	GO:0032757	9.63	IL1B TNF
10	positive regulation of mitotic nuclear division	GO:0045840	9.63	IL1A IL1B
11	positive regulation of vascular endothelial growth factor production	GO:0010575	9.62	IL1A IL1B
12	negative regulation of neurogenesis	GO:0050768	9.62	IL1B TNF
13	positive regulation of interleukin-6 secretion	GO:2000778	9.61	IL1B NLRP10
14	establishment of skin barrier	GO:0061436	9.6	FLG KRT16
15	negative regulation of lipid catabolic process	GO:0050995	9.59	IL1B TNF
16	positive regulation of glial cell proliferation	GO:0060252	9.58	IL1B TNF
17	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.58	IL1B TNF
18	peptide cross-linking	GO:0018149	9.58	FLG LCE2B PI3
19	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.57	IL1B TNF
20	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.56	IL1B TNF
21	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.55	IL1A IL1B
22	positive regulation of chemokine biosynthetic process	GO:0045080	9.52	IL1B TNF
23	ectopic germ cell programmed cell death	GO:0035234	9.49	IL1A IL1B
24	regulation of establishment of endothelial barrier	GO:1903140	9.48	IL1B TNF
25	positive regulation of neuroinflammatory response	GO:0150078	9.46	IL1B TNF
26	positive regulation of fever generation	GO:0031622	9.43	IL1B TNF
27	chronic inflammatory response to antigenic stimulus	GO:0002439	9.37	IL1B TNF
28	sequestering of triglyceride	GO:0030730	9.32	IL1B TNF
29	fever generation	GO:0001660	9.26	IL1A IL1B
30	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.16	IL1B TNF
31	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.13	IL1A IL1B TNF
32	inflammatory response	GO:0006954	9.1	IL1A IL1B KRT16 MS4A2 NLRP10 TNF

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	9.43	FLG KRT16 LCE2B
2	cytokine activity	GO:0005125	9.33	IL1A IL1B TNF
3	structural constituent of epidermis	GO:0030280	8.96	FLG PI3
4	interleukin-1 receptor binding	GO:0005149	8.62	IL1A IL1B

Sources

Sources for Irritant Dermatitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia