Irritant Dermatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IRR003 MIFTS: 47	Irritant Dermatitis Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Irritant Dermatitis

MalaCards integrated aliases for Irritant Dermatitis:

Name: Irritant Dermatitis ¹² ¹⁵ ¹⁷

Irritant Contact Dermatitis ¹² ³²

Dermatitis, Irritant ⁴³ ⁷¹

Contact Dermatitis, Irritant ⁷⁴

Primary Irritant Dermatitis ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Dermatitis and eczema

Irritant contact dermatitis

Irritant contact dermatitis due to cosmetics

Irritant contact dermatitis due to detergents

Irritant contact dermatitis due to drugs in contact with skin

Irritant contact dermatitis due to food in contact with skin

Irritant contact dermatitis due to oils and greases

Irritant contact dermatitis due to other agents

Irritant contact dermatitis due to other chemical products

Irritant contact dermatitis due to plants, except food

Irritant contact dermatitis due to solvents

Irritant contact dermatitis, unspecified cause

External Ids:

Disease Ontology ¹² DOID:2772

MeSH ⁴³ D017453

NCIt ⁴⁹ C27151

ICD10 ³² L24 L24.0 L24.1 more

EFO ¹⁷ EFO_1000718

UMLS ⁷¹ C0162823

Sources

Summaries for Irritant Dermatitis

Disease Ontology : ¹² A contact dermatitis that is characterized by a cutaneous inflammatory reaction to repeated contact with an irritant substance, friction, liquid, or adverse temperature that interacts with the skin and often has symptom erythema, edema, scaling, pain, pruritis, or burning sensation.

MalaCards based summary : Irritant Dermatitis, also known as irritant contact dermatitis, is related to latex allergy and scabies, and has symptoms including erythema An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Mineral oil and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and liver.

Wikipedia : ⁷⁴ Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

Sources

Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 423)

#	Related Disease	Score	Top Affiliating Genes
1	latex allergy	30.5	TNF IL4 FLG
2	scabies	30.4	IL1A FLG CXCL8
3	exanthem	30.3	TNF IL6 CXCL8
4	erythema multiforme	30.3	TNF IL6 IL4 CXCL8
5	sleep apnea	30.1	TNF IL6 IL1B CXCL8
6	conjunctivitis	30.1	TNF IL6 IL4 CXCL8
7	liver disease	29.9	TNF IL6 IL1B IL1A CXCL8
8	candidiasis	29.7	TNF IL6 IL4 IL1B CXCL8
9	basal cell carcinoma	29.6	TNF KRT16 IVL IL6 CXCL8
10	allergic hypersensitivity disease	29.5	TSLP TNF IL4 FLG CXCL8
11	urticaria	29.4	TNF IL6 IL4 IL31
12	proteasome-associated autoinflammatory syndrome 1	28.9	TNF IL6 IL4 IL1B IL1A CXCL8
13	allergic contact dermatitis	28.7	TNF IL6 IL4 IL31 IL1B FLG
14	dermatitis	28.7	TSLP TNF LORICRIN KRT16 IVL IL6
15	contact dermatitis	28.1	TNF KRT16 IVL IL6 IL4 IL31
16	skin disease	27.3	TSLP TNF LORICRIN KRT16 IVL IL6
17	dermatitis, atopic	27.1	TSLP TNF LORICRIN IVL IL6 IL4
18	psoriasis	26.7	TNF LORICRIN KRT16 IVL IL6 IL4
19	clear cell acanthoma	10.5	IVL FLG
20	systemic onset juvenile idiopathic arthritis	10.5	TNF IL1B
21	leukoregulin	10.5	IL1A CXCL8
22	tropical endomyocardial fibrosis	10.5	TNF IL4
23	staphylococcal toxic shock syndrome	10.5	TNF IL1B
24	external pathological resorption	10.5	TNF IL6
25	erythrokeratoderma	10.5	LORICRIN IVL FLG
26	scorpion envenomation	10.5	TNF IL6
27	discoid lupus erythematosus	10.4	KRT16 IVL FLG
28	ichthyosis, congenital, autosomal recessive 4b	10.4	LORICRIN IVL FLG
29	vulvar vestibulitis syndrome	10.4	TNF IL1B
30	palladium allergic contact dermatitis	10.4	TNF IL1B
31	angelucci's syndrome	10.4	IL1B CXCL8
32	dermatitis, atopic, 8	10.4	IL1B CXCL8
33	kashin-beck disease	10.4	TNF IL1B
34	ichthyosis vulgaris	10.4	LORICRIN IVL FLG
35	esophagus melanoma	10.4	IL1B CXCL8
36	angioimmunoblastic lymphadenopathy with dysproteinemia	10.4	TNF IL6
37	pachyonychia congenita 1	10.4	LORICRIN KRT16 FLG
38	prosthetic joint infection	10.4	IL6 IL1B
39	palmoplantar keratoderma, epidermolytic	10.4	LORICRIN KRT16 FLG
40	osteosclerotic myeloma	10.4	IL6 IL1B
41	paratyphoid fever	10.4	TNF IL1B IL1A
42	periodontitis, chronic	10.4	IL6 IL1B
43	keratoacanthoma	10.4	KRT16 IVL FLG
44	acute transverse myelitis	10.4	IL6 CXCL8
45	dermatitis, atopic, 3	10.4	TSLP FLG
46	haemophilus influenzae	10.4	TNF CXCL8
47	orofacial granulomatosis	10.3	TNF IL4 FLG
48	toxicodendron dermatitis	10.3	TNF CXCL8
49	post-transplant lymphoproliferative disease	10.3	TNF IL6 IL1A
50	predominantly cortical thymoma	10.3	IVL CD1E

Graphical network of the top 20 diseases related to Irritant Dermatitis:

Sources

Symptoms & Phenotypes for Irritant Dermatitis

Symptoms:

¹²

• erythema

Sources

Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Mineral oil

Approved, Vet_approved

Phase 4

8042-47-5

Synonyms:

Food Grade Mineral Oil

Heavy Liquid Petrolatum

Heavy mineral oil

Liquid Paraffin

Liquid Petrolatum

Mineral Oil (high Viscosity)

Mineral Oil, Heavy

Paraffin Oil

Paraffin, Liquid

Paraffinum Liquidum

Petrolatum, Liquid

White Mineral Oil

Glycerol

Approved, Investigational

Phase 4

56-81-5

753

Synonyms:

1,2,3-propanetriol

1,2,3-Propanetriol

1,2,3-trihydroxypropane

1,2,3-Trihydroxypropane

Bulbold

Cristal

e 422

Emery 916

Glyceol opthalgan

Glycerin

Glycerin, anhydrous

Glycerin,anhydrous

Glycerine

glycérine

Glycerinum

Glyceritol

Glycerol

glycérol

Glycerolum

Glycyl alcohol

Glyrol

Glysanin

Glyzerin

Gro

IFP

Incorporation factor

Mackstat H 66

Monoctanoin component D

Oelsuess

Ölsüß

Osmoglyn

Pricerine 9091

Propanetriol

RG-S

Trihydroxypropane

Tryhydroxypropane

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Synonyms:

(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11b,16a,17a,21-Tetrahydroxy-9a-fluoro-1,4-pregnadiene-3,20-dione

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione

11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione

11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

124-94-7

4-08-00-03629 (Beilstein Handbook Reference)

83474-03-7

9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d

9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone

9a-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-16a-Hydroxyprednisolone

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9alpha-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-11beta,16alpha,17alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-16alpha-Hydroxyprednisolone

9alpha-Fluoro-16alpha-hydroxyprednisolone

9-alpha-Fluoro-16-alpha-hydroxyprednisolone

9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-16α-hydroxyprednisolone

AC1L1LDH

AC1Q5HJC

AC-2072

Adcortyl

Aristocort

Aristocort A

Aristocort Tablets

Aristogel

Aristospan

Azmacort

Bio-0662

BPBio1_000154

BRD-K77554836-001-03-3

BRN 2341955

BSPBio_000140

C21H27FO6

Celeste

CHEMBL1451

CID31307

Cinolone

Cinolone-T

CL 19823

D00385

D014221

DB00620

Delphicort

droxypregna-1,4-diene-3,20-dione

EINECS 204-718-7

EU-0101179

Fluoxiprednisolone

Fluoxyprednisolone

Flutex

Fougera

HMS1568G22

HMS2090D12

HSDB 3194

ione

Kenacort

Kenacort (TN)

Kenacort-A

Kenacort-Ag

Kenacort-AG

Kenalog

Kenalog in Orabase

Kenalog-10

Kenalog-40

Kenalog-H

Ledercort

Lopac0_001179

LS-698

MLS000028542

MLS001066543

MLS002695935

MolPort-002-528-981

Mycolog

Nasacort

Nasacort Aq

Nasacort Hfa

NCGC00021580-03

NCGC00021580-04

NCGC00021580-05

NCGC00021580-06

NCGC00021580-07

nchembio.2007.53-comp7

NCI60_000750

NSC 13397

NSC13397

Omcilon

Omicilon

Oracort

Oralone

Orion

Polcortolon

Pregna-1,4-diene-3,20-dio

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)

Prestwick_438

Prestwick0_000120

Prestwick1_000120

Prestwick2_000120

Prestwick3_000120

Rodinolone

S1933_Selleck

Sk-Triamcinolone

SK-Triamcinolone

SMP1_000300

SMR000058333

SPBio_002079

T6376_SIGMA

Tiamcinolonum

Tiamcinolonum [INN-Latin]

Triacet

Triacort

Triamcet

Triamcinalone

Triamcinlon

Triamcinolon

Triamcinolona

Triamcinolona [INN-Spanish]

triamcinolone

Triamcinolone

Triamcinolone (JP15/USP/INN)

TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))

Triamcinolone [USAN:INN:BAN:JAN]

Triamcinolone acetonide

Triamcinolone diacetate

Triamcinolone hexacetonide

Triamcinolonum

Triamcinolonum [INN]

Triam-Tablinen

Triatex

Tricortale

Triderm

Trilone

Tri-Nasal

Tristoject

Trymex

UNII-1ZK20VI6TY

Vetalog

Volon

Volon A

WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ

ZINC03882036

Clobetasol

Approved, Experimental, Investigational

Phase 4

25122-46-7, 25122-41-2

32798 5311051

Synonyms:

(11b,16b)-21-chloro-9-fluoro-11,17-Dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11beta,16beta)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11beta,16beta)-21-chloro-9-fluoro-11,17-Dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11β,16β)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

(9R,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione

21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate

25122-41-2

AC-1775

AC1L1OG6

AC1NDRJ9

AC1NSJWK

BB_NC-1906

C22H28ClFO4

CHEBI:205919

CHEMBL1201362

CID10341542

CID32797

CID4630419

CID5311051

CID9844480

Clobecort Amex

Clobecort Amex (TN)

clobetasol

Clobetasol

Clobetasol (INN)

Clobetasol [INN:BAN]

Clobetasol 17 propionate

clobetasol 17-propanoate

clobetasol 17-propionate

Clobetasol 17-propionate

Clobetasol propionate

Clobetasol propionate E

Clobetasolum

Clobetasolum [INN-Latin]

Clobex

Clofenazon

Cormax

D07715

Dermovate

EINECS 246-633-8

Embeline

Embeline e

LS-174086

MolPort-005-909-335

NCGC00164580-01

OLUX

STK801976

Temovate

UNII-ADN79D536H

ZINC26892643

Apremilast

Approved, Investigational

Phase 4

608141-41-9

11561674

Synonyms:

Apremilast

Aprémilast

Apremilast (USAN)

Apremilastum

CC-10004

CHEBI:558773

CHEMBL514800

CID11561674

D08860

N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide

N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

Hormone Antagonists

Phase 4

triamcinolone acetonide

Phase 4

Protective Agents

Phase 4

Triamcinolone diacetate

Phase 4

glucocorticoids

Phase 4

Hormones

Phase 4

Triamcinolone hexacetonide

Phase 4

Anti-Infective Agents

Phase 4

Angiogenesis Inhibitors

Phase 4

Anti-Bacterial Agents

Phase 4

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

Synonyms:

(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

01769_FLUKA

2d0k

33609-88-0

36653-55-1 (mono-potassium salt)

59-30-3

6484-89-5 (mono-hydrochloride salt)

AC-11682

AC1L1LNX

Acfol (Spain)

Acide folique

Acide folique [INN-French]

Acido folico

ácido fólico

Acido folico [INN-Spanish]

Acidum folicum

Acidum folicum [INN-Latin]

Acifolic

AI3-26387

AKOS000503224

Antianemia factor

Apo-Folic

ARONIS014410

b9, Vitamin

BIDD:ER0563

BIDD:GT0641

BIF0608

bmse000299

BPBio1_000654

BSPBio_000594

BSPBio_002338

C00504

C20H20N6O6

CAS-59-30-3

CCRIS 666

CHEBI:27470

CHEMBL1622

CID6037

CPD000471860

Cytofol

D00070

DB00158

DivK1c_000494

Dosfolat b activ

Dosfolat B activ

EINECS 200-419-0

F0043

F7876_SIAL

F7876_SIGMA

F8758_SIGMA

F8798_SIAL

F8890_SIGMA

Facid

Factor U

FOL

Folacid

Folacin

Folaemin

Folaemin [Netherlands]

Folan

Folasic (Australia)

Folate

Folbal

Folcidin

Folcidin (VAN)

Folcysteine

Foldine

Foldine [France]

Folettes

Foliamin

Folic

folic acid

Folic acid

Folic acid (JP15/USP/INN)

Folic acid (TN)

Folic acid [BAN:INN:JAN]

Folic acid [INN:BAN:JAN]

Folic acid dihydrate

Folic acid, (D)-isomer

Folic acid, (DL)-isomer

Folic acid, calcium salt (1:1)

Folic acid, monopotassium salt

Folic acid, monosodium salt

Folic acid, potassium salt

Folic acid, sodium salt

Folicet

Folicet (TN)

Folico

Folico (Italy)

Folina

Folina (Italy)

Folipac

Folsaeure

Folsan

Folsaure

Folsäure

Folsav

Folvite

Folvron

Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L

HMS1921D20

HMS2092N17

HMS501I16

HSDB 2002

IDI1_000494

Incafolic

InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s

KBio1_000494

KBio2_001861

KBio2_004429

KBio2_006997

KBio3_001558

KBioGR_002222

KBioSS_001861

Kyselina listova

Kyselina listova [Czech]

Liver lactobacillus casei factor

Liver Lactobacillus casei factor

LS-2157

Millafol

Mission prenatal

Mittafol

MLS001304016

MLS001335861

MolPort-004-285-551

N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid

N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamate

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid

N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-Pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

NCGC00016265-01

NCGC00142391-01

nchembio.108-comp10

Nifolin

Nifolin [Denmark]

NINDS_000494

Novofolacid

Novofolacid [Canada]

N-Pteroyl-L-glutamate

N-pteroyl-L-glutamic acid

N-Pteroyl-L-glutamic acid

NSC 3073

PGA

PGA (VAN)

Prestwick_230

Prestwick3_000627

PteGlu

Pteroylglutamate

Pteroylglutamic acid

Pteroyl-L-glutamate

Pteroyl-L-glutamic acid

Pteroyl-L-monoglutamate

Pteroyl-L-monoglutamic acid

Pteroylmonoglutamate

Pteroylmonoglutamic acid

SAM002264616

SDCCGMLS-0066738.P001

Serum Folate Level

SMP2_000137

SMR000471860

SPBio_001357

Spectrum_001381

SPECTRUM1502020

Spectrum2_001459

Spectrum3_000749

Spectrum4_001751

Spectrum5_000602

UNII-935E97BOY8

Usaf cb-13

Vitamin B11

Vitamin b9

Vitamin B9

Vitamin Bc

Vitamin BC

Vitamin be

Vitamin Be

Vitamin m

Vitamin M

Pantothenic acid

Approved, Nutraceutical, Vet_approved

Phase 3

79-83-4

6613

Synonyms:

(+)-Pantothenic acid

(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine

Chick antidermatitis factor

D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine

D-(+)-Pantothenic acid

D-pantothenic acid

D-Pantothenic acid

N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-beta-alanine

Pantothenate

PANTOTHENOIC ACID

Vitamin b5

Vitamin B5

Trace Elements

Phase 3

Vitamins

Phase 3

Micronutrients

Phase 3

Vitamin B Complex

Phase 3

Nutrients

Phase 3

Folate

Phase 3

Vitamin B9

Phase 3

Mitogens

Phase 3

Provitamins

Phase 3

Emollients

Anesthetics

Interventional clinical trials:

(show all 15)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Experimentally Induced Skin Irritation	Unknown status	NCT00779792	Phase 4	clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
2	An Open-label, Single-Arm Pilot Study Investigating the Efficacy and Safety of Apremilast for the Treatment of Moderate to Severe Chronic Hand Dermatitis	Terminated	NCT03741933	Phase 4	Apremilast 30mg
3	Phase III Randomized Double-Blind Trial of Bepanthen® Cream Versus Cetomacrogol Cream in the Prevention of Papulopustular Eruption in Patients Receiving Epidermal Growth Factor Receptor Inhibitors (EGFRI): BeCet	Completed	NCT01136005	Phase 3
4	Bariederm Cream in Chronic Contact Dermatitis	Unknown status	NCT02026700
5	Chemokine Expression in Nummular Dermatitis and Atopic Dermatitis	Unknown status	NCT01311986
6	Hand Eczema Trial: A Randomised Clinical Trial of the Effect of Classification and Individual Counselling Among Health Care Workers With Hand Eczema	Unknown status	NCT01012453
7	Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery: A Randomised, Controlled Trial	Completed	NCT03231813
8	Prospective Single Center Randomized Double Blind Controlled Tolerability Trial of Six Hair Cleansing Conditioners	Completed	NCT03483025
9	Specific Factors Associated With the Development of Incontinence- Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence: Matched Case Control Study	Completed	NCT02996357
10	An Open Label Study of the Therapeutic Effects of Tetrix Cream in Allergic Contact and Irritant Contact Dermatitis	Completed	NCT00646867
11	Histopathological Comparison Between Superficial Pressure Ulcers and Incontinence-associated Dermatitis	Not yet recruiting	NCT03685929
12	A Total Body Wash Wipe Combined With a Genital Wipe Versus Standard Care (Water and pH Neutral Soap) for Washing of Incontinent Residents in a Long- Term Care Setting: a Multicenter Prospective Randomised Controlled Clinical Trial and Health Economical Analysis in Nursing Homes	Terminated	NCT02475512
13	Peristomal Skin Irritation: A Preliminary Evaluation of the CASTLE Barrier Prototype for People With Intestinal Stomas	Terminated	NCT01530087
14	Vulvar Contact Dermatitis Resulting From Urine Incontinence: Prevalence, Characteristics and Risk Factors	Withdrawn	NCT01320046
15	Evaluation of the Therapeutic Effect and Local Tolerability of Elidel® Cream 1% (Pimecrolimus) in Chronic Discoid Lupus Erythematosus (dLE) or Subacute Cutaneous Lupus Erythematosus (scLE)	Withdrawn	NCT00222183		Elidel (pimecrolimus)

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

Sources

Genetic Tests for Irritant Dermatitis

Sources

Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

⁴⁰

Skin, Testes, Liver, T Cells, Thyroid, Bone, Lung

Sources

Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 1406)

#	Title	Authors	PMID	Year
1	Anti-inflammatory effect of lanoconazole on 12-O-tetradecanoylphorbol-13-acetate- and 2,4,6-trinitrophenyl chloride-induced skin inflammation in mice. ⁶¹	Nakamura A...Matsumoto T	31724251	2020
2	12-year data on dermatologic cases in the Finnish Register of Occupational Diseases I: Distribution of different diagnoses and main causes of allergic contact dermatitis. ⁶¹	Aalto-Korte K...Pesonen M	32037572	2020
3	Management of incontinence-associated dermatitis patients using a skin protectant in acute care: a case series. ⁶¹	Acton C...Browning P	31930942	2020
4	Oral administration of whole dihomo-γ-linolenic acid-producing yeast suppresses allergic contact dermatitis in mice. ⁶¹	Watanabe N...Uemura H	31532348	2020
5	CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls. ⁶¹	Lugovic-Mihic L...Bukvic I	31900953	2020
6	Severe irritant reaction following sequential waxing and use of a chemical depilatory cream in an adolescent. ⁶¹	Kiene J...DeKlotz CMC	31769049	2020
7	Does Adherence to World Health Organization Hand Hygiene Protocols in the Operating Room Have the Potential to Produce Irritant Contact Dermatitis in Anesthesia Providers? ⁶¹	Birnbach DJ...Lindsey SF	31743176	2019
8	Hand eczema treatment: Change behaviour with text messaging, a randomized trial. ⁶¹	Erdil D...Gurel MS	31794053	2019
9	Oleylamine-induced pustular irritant contact dermatitis. ⁶¹	Yoo S...Lee J	31389016	2019
10	Possible roles of basophils in chronic itch. ⁶¹	Hashimoto T...Yosipovitch G	29894005	2019
11	Tandem repeated irritation test (TRIT) studies and clinical relevance: Post 2006. ⁶¹	Reddy R...Maibach H	29886752	2019
12	Triclosen and Its Alternatives in Antibacterial Soaps. ⁶¹	Rundle CW...Dunnick CA	31688130	2019
13	Irritant contact dermatitis due to Euphorbia trigona. ⁶¹	Elmas OF	31782156	2019
14	Irritant contact dermatitis caused by a shower cream used as a leave-on product. ⁶¹	Opstrup MS...Yazdanyar S	31265145	2019
15	Facial Dermatitis in Male Patients Referred for Patch Testing: Retrospective Analysis of North American Contact Dermatitis Group Data, 1994 to 2016. ⁶¹	Warshaw EM...Zirwas MJ	31774459	2019
16	In Vivo Reflectance Confocal Microscopy: Emerging Role in Noninvasive Diagnosis and Monitoring of Eczematous Dermatoses. ⁶¹	Maarouf M...Shi VY	31202471	2019
17	Fiberglass dermatitis: clinical presentations, prevention, and treatment - a review of literatures. ⁶¹	Camacho I...Tosti A	30816574	2019
18	Histopathology of sabra dermatitis: A case report. ⁶¹	Esmaeili A...Crowson AN	31033007	2019
19	Combination treatment with lipoteichoic acids isolated from Lactobacillus plantarum and Staphylococcus aureus alleviates atopic dermatitis via upregulation of CD55 and CD59. ⁶¹	Kim Y...Chung DK	31454521	2019
20	Clinical Manifestations, Treatment, and Prevention of Acute Irritant Contact Dermatitis Caused by 2,4-Dichloro-5-Methylpyrimidine Exposure in 64 Cases. ⁶¹	Fan W...Wang L	31688132	2019
21	Challenging a paradigm: skin sensitivity to sodium lauryl sulfate is independent of atopic diathesis. ⁶¹	Heetfeld AB...Buhl T	31562780	2019
22	Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. ⁶¹	Fukuyama T...Fukami K	31338881	2019
23	Irritant Contact Dermatitis With Topical Povidone-Iodine Ointment Post Ear Surgery. ⁶¹	Singh A...Haq M	31547715	2019
24	Botulinum neurotoxin A is an effective treatment for irritant dermatitis caused by ostomy leaks in patients with retractile stomas. ⁶¹	Bhoyrul B...Lyon C	30843191	2019
25	Hydrogel containing silibinin nanocapsules presents effective anti-inflammatory action in a model of irritant contact dermatitis in mice. ⁶¹	Rigon C...Cruz L	31238095	2019
26	Differences in itch and pain behaviors accompanying the irritant and allergic contact dermatitis produced by a contact allergen in mice. ⁶¹	Zhang Z...LaMotte RH	31875186	2019
27	Occupationally Related Nickel Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016. ⁶¹	Warshaw EM...Taylor JS	31524759	2019
28	Microfluidics-based skin irritation test using in vitro 3D angiogenesis platform. ⁶¹	Jusoh N...Jeon NL	31431937	2019
29	IL6Rα function in myeloid cells modulates the inflammatory response during irritant contact dermatitis. ⁶¹	Frempah B...Gallucci RM	31165501	2019
30	Four Cases of Perineal Groove-Experience of a Greek Maternity Hospital. ⁶¹	Boutsikou T...Iacovidou N	31443289	2019
31	Laxative-Induced Contact Dermatitis. ⁶¹	Melvin JE...Hickey RW	29746360	2019
32	Keratinocyte-specific deletion of the IL-6RΑ exacerbates the inflammatory response during irritant contact dermatitis. ⁶¹	Frempah B...Gallucci RM	31158415	2019
33	Bullous irritant contact dermatitis caused by an alcoholic extract from Juglans regia leaves. ⁶¹	Corazza M...Borghi A	30740710	2019
34	Phytodermatitis in East and southeast of Turkey: A prospective study. ⁶¹	An I...Ozturk M	30585511	2019
35	Filaggrin gene mutations in hand eczema patients in the Indian subcontinent: A prospective case-control study. ⁶¹	Handa S...De D	30681730	2019
36	Evaluation of Disposable Protective Garments against Isocyanate Permeation and Penetration from Polyurethane Anticorrosion Coatings. ⁶¹	Mellette MP...Woskie S	31066890	2019
37	Contact Dermatitis in the Elderly: Predisposing Factors, Diagnosis, and Management. ⁶¹	Lima AL...Elsner P	31037642	2019
38	Contact dermatitis and sensitization in professional musicians. ⁶¹	Kraft M...IVDK	30499108	2019
39	"Slime" contact dermatitis: Case report and review of relevant allergens. ⁶¹	Anderson LE...Yu J	30865309	2019
40	Cariniana domestica fruit peels present topical anti-inflammatory efficacy in a mouse model of skin inflammation. ⁶¹	Milani GB...Oliveira SM	30617548	2019
41	Impact of water exposure on skin barrier permeability and ultrastructure. ⁶¹	Ogawa-Fuse C...Fujimura T	30417381	2019
42	Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis. ⁶¹	Shiratori K...Fukami K	30791982	2019
43	A painful periumbilical rash. ⁶¹	Amin S...Fiala K	31191154	2019
44	Non-glaucoma periocular allergic, atopic, and irritant dermatitis at an academic institution: A retrospective review. ⁶¹	Pandit SA...Glass LRD	29985741	2019
45	A review of non-glove personal protective equipment-related occupational dermatoses reported to EPIDERM between 1993 and 2013. ⁶¹	Bhoyrul B...Carder M	30430597	2019
46	Biotin Is Required for the Zinc Homeostasis in the Skin. ⁶¹	Ogawa Y...Kawamura T	31022908	2019
47	Thermography: High sensitivity and specificity diagnosing contact dermatitis in patch testing. ⁶¹	Anzengruber F...Navarini AA	30598404	2019
48	Does Adherence to World Health Organization Hand Hygiene Protocols in the Operating Room Have the Potential to Produce Irritant Contact Dermatitis in Anesthesia Providers? ⁶¹	Birnbach DJ...Lindsey SF	31008747	2019
49	Periwound Challenges Improve Patient Satisfaction in Wound Care. ⁶¹	Wongkietkachorn A...Wongkietkachorn S	31044112	2019
50	Tabernaemontana catharinensis leaves exhibit topical anti-inflammatory activity without causing toxicity. ⁶¹	Camponogara C...Oliveira SM	30445106	2019

Sources

Genes for Irritant Dermatitis

Genes related to Irritant Dermatitis (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IL1A	Interleukin 1 Alpha	Protein Coding	12.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	FLG	Filaggrin	Protein Coding	7.24	DISEASES inferred ¹⁵
3	IVL	Involucrin	Protein Coding	6.19	DISEASES inferred ¹⁵
4	LORICRIN	Loricrin Cornified Envelope Precursor Protein	Protein Coding	6.16	DISEASES inferred ¹⁵
5	OR2B3	Olfactory Receptor Family 2 Subfamily B Member 3	Protein Coding	5.98	DISEASES inferred ¹⁵
6	KRT16	Keratin 16	Protein Coding	5.94	DISEASES inferred ¹⁵
7	TNF	Tumor Necrosis Factor	Protein Coding	5.83	DISEASES inferred ¹⁵
8	IL1B	Interleukin 1 Beta	Protein Coding	5.74	DISEASES inferred ¹⁵
9	LCE2B	Late Cornified Envelope 2B	Protein Coding	5.67	DISEASES inferred ¹⁵
10	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	5.65	DISEASES inferred ¹⁵
11	IL4	Interleukin 4	Protein Coding	5.55	DISEASES inferred ¹⁵
12	IL6	Interleukin 6	Protein Coding	5.51	DISEASES inferred ¹⁵
13	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	5.41	DISEASES inferred ¹⁵
14	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	5.37	DISEASES inferred ¹⁵
15	NLRP10	NLR Family Pyrin Domain Containing 10	Protein Coding	5.32	DISEASES inferred ¹⁵
16	LCE5A	Late Cornified Envelope 5A	Protein Coding	5.28	DISEASES inferred ¹⁵
17	FABP5	Fatty Acid Binding Protein 5	Protein Coding	5.24	DISEASES inferred ¹⁵
18	IL31	Interleukin 31	Protein Coding	5.2	DISEASES inferred ¹⁵
19	CD1E	CD1e Molecule	Protein Coding	5.16	DISEASES inferred ¹⁵

Sources

Variations for Irritant Dermatitis

Sources

Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

Sources

Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.7	TSLP TNF IL6 IL4 IL31 IL1B
2	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.41	TNF IL6 IL4 IL1B IL1A CXCL8
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.38	TNF IL6 IL4 IL31 IL1B IL1A
4	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.31	TNF IL6 IL4 IL1B IL1A CXCL8
5	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.87	TNF IL6 IL4 IL1B IL1A CXCL8
6	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.83	TNF IL6 IL1B IL1A CXCL8 CXCL10
7	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁵ Show member pathways Cytosolic DNA-sensing pathway ³⁶ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of RIG-I/MDA5 signaling ⁶⁵ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁵ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁶ TRAF3-dependent IRF activation pathway ⁶⁵ TRAF6 mediated IRF7 activation ⁶⁵ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁴	12.78	TNF IL6 IL1B CXCL8 CXCL10
8	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.62	TNF IL6 IL4 IL1B IL1A
9	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.62	TNF IL6 IL4 IL1B IL1A
10	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	12.51	LORICRIN LCE5A LCE2B KRT16 IVL FLG
11	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.35	TNF IL6 CXCL8 CXCL10
12	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.35	TNF IL6 IL4 IL1B
13	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.34	TNF IL6 IL1B IL1A CXCL8
14	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.34	TNF IL6 IL4 IL1B CXCL8 CXCL10
15	Pathogenic Escherichia coli infection ³⁶	12.32	TNF IL6 IL1B CXCL8
16	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.3	TNF IL6 IL4 IL1B IL1A CXCL8
17	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.28	TNF IL6 IL1A CXCL8
18	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.28	TNF IL4 IL1B IL1A
19	IL-1 Family Signaling Pathways ⁶⁴ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.26	TNF IL6 IL1B IL1A CXCL8
20	NOD-like receptor signaling pathway ³⁶	12.25	TNF IL6 IL1B CXCL8
21	Tuberculosis ³⁶	12.25	TNF IL6 IL1B IL1A
22	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.21	TNF IL6 IL1B IL1A CXCL8
23	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.15	TNF IL6 IL4 IL1B CXCL8 CXCL10
24	Microglia Activation During Neuroinflammation: Overview ⁶⁴ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁴	12.07	TNF IL6 IL4 IL1B
25	Yersinia infection ³⁶	12.04	TNF IL6 IL1B CXCL8
26	TNF signaling pathway ³⁶	12	TNF IL6 IL1B CXCL10
27	Senescence and Autophagy in Cancer ¹	11.96	IL6 IL1B IL1A CXCL8
28	Amoebiasis ³⁶	11.95	TNF IL6 IL1B CXCL8 CD1E
29	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.93	TNF IL6 IL1B IL1A CXCL8
30	Interleukin-4 and 13 signaling ⁶⁵	11.9	TNF IL6 IL4 IL1B IL1A CXCL8
31	Rheumatoid arthritis ³⁶	11.88	TNF IL6 IL1B IL1A CXCL8
32	Salmonella infection (KEGG) ³⁶	11.83	IL6 IL1B IL1A CXCL8
33	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.83	TSLP TNF IL4 IL1B
34	Glucocorticoid receptor regulatory network ¹	11.81	IL6 IL4 CXCL8
35	Hematopoietic cell lineage ³⁶	11.79	TNF IL6 IL4 IL1B IL1A CD1E
36	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.78	TNF IL4 CXCL8
37	Pertussis ³⁶	11.77	TNF IL6 IL1B IL1A CXCL8
38	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.76	TNF IL6 IL1B
39	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁴	11.73	TNF IL6 IL4 IL1B CXCL10
40	Legionellosis ³⁶	11.66	TNF IL6 IL1B CXCL8
41	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.63	TNF IL6 IL1B IL1A CXCL8
42	Lung fibrosis ¹	11.6	TNF IL6 IL4 IL1B CXCL8
43	Malaria ³⁶	11.58	TNF IL6 IL1B CXCL8
44	Spinal Cord Injury ¹	11.58	TNF IL6 IL4 IL1B IL1A CXCL8
45	Hematopoietic Stem Cell Differentiation ¹	11.55	IL6 IL1B IL1A
46	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.54	TSLP IL6 CXCL8
47	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.52	TNF IL6 IL1B IL1A
48	African trypanosomiasis ³⁶	11.42	TNF IL6 IL1B
49	Prion diseases ³⁶	11.4	IL6 IL1B IL1A
50	IL-10 Pathway ⁶³	11.4	TNF IL6 IL1B IL1A

Sources

GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.65	TSLP TNF IL6 IL4 IL31 IL1B
2	extracellular space	GO:0005615	9.36	TSLP TNF IL6 IL4 IL31 IL1B
3	cornified envelope	GO:0001533	9.33	LORICRIN IVL FLG

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 32)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.04	TNF IL6 IL4 IL1B IL1A
2	cornification	GO:0070268	9.87	LORICRIN KRT16 IVL FLG
3	immune response	GO:0006955	9.86	TNF IL6 IL4 IL1B IL1A CXCL8
4	keratinization	GO:0031424	9.85	LORICRIN LCE5A LCE2B KRT16 IVL
5	positive regulation of JNK cascade	GO:0046330	9.83	TNF IL1B IL1A
6	positive regulation of inflammatory response	GO:0050729	9.83	TSLP TNF NLRP10 IL1B
7	positive regulation of T cell proliferation	GO:0042102	9.81	IL6 IL4 IL1B
8	neutrophil chemotaxis	GO:0030593	9.81	IL1B IL1A CXCL8 CXCL10
9	cellular response to lipopolysaccharide	GO:0071222	9.8	TNF IL6 IL1B IL1A CXCL8 CXCL10
10	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.77	TNF IL1B IL1A
11	positive regulation of interleukin-6 secretion	GO:2000778	9.75	TNF NLRP10 IL1B
12	positive regulation of vascular endothelial growth factor production	GO:0010575	9.73	IL6 IL1B IL1A
13	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.73	TSLP TNF IL6 IL4
14	negative regulation of neurogenesis	GO:0050768	9.72	TNF IL6 IL1B
15	peptide cross-linking	GO:0018149	9.71	LORICRIN IVL FLG
16	positive regulation of chemokine production	GO:0032722	9.67	TSLP TNF IL6
17	keratinocyte differentiation	GO:0030216	9.67	LORICRIN KRT16 IVL FLG
18	positive regulation of chemokine biosynthetic process	GO:0045080	9.65	TNF IL1B
19	positive regulation of interleukin-13 production	GO:0032736	9.65	TSLP IL4
20	positive regulation of glial cell proliferation	GO:0060252	9.65	TNF IL6 IL1B
21	negative regulation of lipid storage	GO:0010888	9.64	TNF IL6
22	regulation of establishment of endothelial barrier	GO:1903140	9.63	TNF IL1B
23	ectopic germ cell programmed cell death	GO:0035234	9.62	IL1B IL1A
24	positive regulation of fever generation	GO:0031622	9.62	TNF IL1B
25	negative regulation of glucose transmembrane transport	GO:0010829	9.61	IL1B FABP5
26	sequestering of triglyceride	GO:0030730	9.61	TNF IL1B
27	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.59	TNF IL1B
28	fever generation	GO:0001660	9.58	IL1B IL1A
29	positive regulation of neuroinflammatory response	GO:0150078	9.58	TNF IL6 IL1B
30	inflammatory response	GO:0006954	9.56	TNF NLRP10 KRT16 IL6 IL1B IL1A
31	positive regulation of interleukin-6 production	GO:0032755	9.55	TSLP TNF IL6 IL1B IL1A
32	cytokine-mediated signaling pathway	GO:0019221	9.23	TNF IL6 IL4 IL31 IL1B IL1A

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.28	TSLP TNF IL6 IL4 IL31 IL1B

Sources

Sources for Irritant Dermatitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia