Aliases & Classifications for Irritant Dermatitis

Summaries for Irritant Dermatitis

Disease Ontology : 12 A contact dermatitis that is characterized by a cutaneous inflammatory reaction to repeated contact with an irritant substance, friction, liquid, or adverse temperature that interacts with the skin and often has symptom erythema, edema, scaling, pain, pruritis, or burning sensation.

MalaCards based summary : Irritant Dermatitis, also known as irritant contact dermatitis, is related to latex allergy and scabies, and has symptoms including erythema An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Mineral oil and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and liver.

Wikipedia : 74 Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 423)
# Related Disease Score Top Affiliating Genes
1 latex allergy 30.5 TNF IL4 FLG
2 scabies 30.4 IL1A FLG CXCL8
3 exanthem 30.3 TNF IL6 CXCL8
4 erythema multiforme 30.3 TNF IL6 IL4 CXCL8
5 sleep apnea 30.1 TNF IL6 IL1B CXCL8
6 conjunctivitis 30.1 TNF IL6 IL4 CXCL8
7 liver disease 29.9 TNF IL6 IL1B IL1A CXCL8
8 candidiasis 29.7 TNF IL6 IL4 IL1B CXCL8
9 basal cell carcinoma 29.6 TNF KRT16 IVL IL6 CXCL8
10 allergic hypersensitivity disease 29.5 TSLP TNF IL4 FLG CXCL8
11 urticaria 29.4 TNF IL6 IL4 IL31
12 proteasome-associated autoinflammatory syndrome 1 28.9 TNF IL6 IL4 IL1B IL1A CXCL8
13 allergic contact dermatitis 28.7 TNF IL6 IL4 IL31 IL1B FLG
14 dermatitis 28.7 TSLP TNF LORICRIN KRT16 IVL IL6
15 contact dermatitis 28.1 TNF KRT16 IVL IL6 IL4 IL31
16 skin disease 27.3 TSLP TNF LORICRIN KRT16 IVL IL6
17 dermatitis, atopic 27.1 TSLP TNF LORICRIN IVL IL6 IL4
18 psoriasis 26.7 TNF LORICRIN KRT16 IVL IL6 IL4
19 clear cell acanthoma 10.5 IVL FLG
20 systemic onset juvenile idiopathic arthritis 10.5 TNF IL1B
21 leukoregulin 10.5 IL1A CXCL8
22 tropical endomyocardial fibrosis 10.5 TNF IL4
23 staphylococcal toxic shock syndrome 10.5 TNF IL1B
24 external pathological resorption 10.5 TNF IL6
25 erythrokeratoderma 10.5 LORICRIN IVL FLG
26 scorpion envenomation 10.5 TNF IL6
27 discoid lupus erythematosus 10.4 KRT16 IVL FLG
28 ichthyosis, congenital, autosomal recessive 4b 10.4 LORICRIN IVL FLG
29 vulvar vestibulitis syndrome 10.4 TNF IL1B
30 palladium allergic contact dermatitis 10.4 TNF IL1B
31 angelucci's syndrome 10.4 IL1B CXCL8
32 dermatitis, atopic, 8 10.4 IL1B CXCL8
33 kashin-beck disease 10.4 TNF IL1B
34 ichthyosis vulgaris 10.4 LORICRIN IVL FLG
35 esophagus melanoma 10.4 IL1B CXCL8
36 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
37 pachyonychia congenita 1 10.4 LORICRIN KRT16 FLG
38 prosthetic joint infection 10.4 IL6 IL1B
39 palmoplantar keratoderma, epidermolytic 10.4 LORICRIN KRT16 FLG
40 osteosclerotic myeloma 10.4 IL6 IL1B
41 paratyphoid fever 10.4 TNF IL1B IL1A
42 periodontitis, chronic 10.4 IL6 IL1B
43 keratoacanthoma 10.4 KRT16 IVL FLG
44 acute transverse myelitis 10.4 IL6 CXCL8
45 dermatitis, atopic, 3 10.4 TSLP FLG
46 haemophilus influenzae 10.4 TNF CXCL8
47 orofacial granulomatosis 10.3 TNF IL4 FLG
48 toxicodendron dermatitis 10.3 TNF CXCL8
49 post-transplant lymphoproliferative disease 10.3 TNF IL6 IL1A
50 predominantly cortical thymoma 10.3 IVL CD1E

Graphical network of the top 20 diseases related to Irritant Dermatitis:



Diseases related to Irritant Dermatitis

Symptoms & Phenotypes for Irritant Dermatitis

Symptoms:

12
  • erythema

Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
2
Glycerol Approved, Investigational Phase 4 56-81-5 753
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
5
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
6 Hormone Antagonists Phase 4
7 triamcinolone acetonide Phase 4
8 Protective Agents Phase 4
9 Triamcinolone diacetate Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Triamcinolone hexacetonide Phase 4
13 Anti-Infective Agents Phase 4
14 Angiogenesis Inhibitors Phase 4
15 Anti-Bacterial Agents Phase 4
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
17
Pantothenic acid Approved, Nutraceutical, Vet_approved Phase 3 79-83-4 6613
18 Trace Elements Phase 3
19 Vitamins Phase 3
20 Micronutrients Phase 3
21 Vitamin B Complex Phase 3
22 Nutrients Phase 3
23 Folate Phase 3
24 Vitamin B9 Phase 3
25 Mitogens Phase 3
26 Provitamins Phase 3
27 Emollients
28 Anesthetics

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Comparison of Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Experimentally Induced Skin Irritation Unknown status NCT00779792 Phase 4 clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
2 An Open-label, Single-Arm Pilot Study Investigating the Efficacy and Safety of Apremilast for the Treatment of Moderate to Severe Chronic Hand Dermatitis Terminated NCT03741933 Phase 4 Apremilast 30mg
3 Phase III Randomized Double-Blind Trial of Bepanthen® Cream Versus Cetomacrogol Cream in the Prevention of Papulopustular Eruption in Patients Receiving Epidermal Growth Factor Receptor Inhibitors (EGFRI): BeCet Completed NCT01136005 Phase 3
4 Bariederm Cream in Chronic Contact Dermatitis Unknown status NCT02026700
5 Chemokine Expression in Nummular Dermatitis and Atopic Dermatitis Unknown status NCT01311986
6 Hand Eczema Trial: A Randomised Clinical Trial of the Effect of Classification and Individual Counselling Among Health Care Workers With Hand Eczema Unknown status NCT01012453
7 Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery: A Randomised, Controlled Trial Completed NCT03231813
8 Prospective Single Center Randomized Double Blind Controlled Tolerability Trial of Six Hair Cleansing Conditioners Completed NCT03483025
9 Specific Factors Associated With the Development of Incontinence- Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence: Matched Case Control Study Completed NCT02996357
10 An Open Label Study of the Therapeutic Effects of Tetrix Cream in Allergic Contact and Irritant Contact Dermatitis Completed NCT00646867
11 Histopathological Comparison Between Superficial Pressure Ulcers and Incontinence-associated Dermatitis Not yet recruiting NCT03685929
12 A Total Body Wash Wipe Combined With a Genital Wipe Versus Standard Care (Water and pH Neutral Soap) for Washing of Incontinent Residents in a Long- Term Care Setting: a Multicenter Prospective Randomised Controlled Clinical Trial and Health Economical Analysis in Nursing Homes Terminated NCT02475512
13 Peristomal Skin Irritation: A Preliminary Evaluation of the CASTLE Barrier Prototype for People With Intestinal Stomas Terminated NCT01530087
14 Vulvar Contact Dermatitis Resulting From Urine Incontinence: Prevalence, Characteristics and Risk Factors Withdrawn NCT01320046
15 Evaluation of the Therapeutic Effect and Local Tolerability of Elidel® Cream 1% (Pimecrolimus) in Chronic Discoid Lupus Erythematosus (dLE) or Subacute Cutaneous Lupus Erythematosus (scLE) Withdrawn NCT00222183 Elidel (pimecrolimus)

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

Genetic Tests for Irritant Dermatitis

Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

40
Skin, Testes, Liver, T Cells, Thyroid, Bone, Lung

Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 1406)
# Title Authors PMID Year
1
Anti-inflammatory effect of lanoconazole on 12-O-tetradecanoylphorbol-13-acetate- and 2,4,6-trinitrophenyl chloride-induced skin inflammation in mice. 61
31724251 2020
2
12-year data on dermatologic cases in the Finnish Register of Occupational Diseases I: Distribution of different diagnoses and main causes of allergic contact dermatitis. 61
32037572 2020
3
Management of incontinence-associated dermatitis patients using a skin protectant in acute care: a case series. 61
31930942 2020
4
Oral administration of whole dihomo-γ-linolenic acid-producing yeast suppresses allergic contact dermatitis in mice. 61
31532348 2020
5
CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls. 61
31900953 2020
6
Severe irritant reaction following sequential waxing and use of a chemical depilatory cream in an adolescent. 61
31769049 2020
7
Does Adherence to World Health Organization Hand Hygiene Protocols in the Operating Room Have the Potential to Produce Irritant Contact Dermatitis in Anesthesia Providers? 61
31743176 2019
8
Hand eczema treatment: Change behaviour with text messaging, a randomized trial. 61
31794053 2019
9
Oleylamine-induced pustular irritant contact dermatitis. 61
31389016 2019
10
Possible roles of basophils in chronic itch. 61
29894005 2019
11
Tandem repeated irritation test (TRIT) studies and clinical relevance: Post 2006. 61
29886752 2019
12
Triclosen and Its Alternatives in Antibacterial Soaps. 61
31688130 2019
13
Irritant contact dermatitis due to Euphorbia trigona. 61
31782156 2019
14
Irritant contact dermatitis caused by a shower cream used as a leave-on product. 61
31265145 2019
15
Facial Dermatitis in Male Patients Referred for Patch Testing: Retrospective Analysis of North American Contact Dermatitis Group Data, 1994 to 2016. 61
31774459 2019
16
In Vivo Reflectance Confocal Microscopy: Emerging Role in Noninvasive Diagnosis and Monitoring of Eczematous Dermatoses. 61
31202471 2019
17
Fiberglass dermatitis: clinical presentations, prevention, and treatment - a review of literatures. 61
30816574 2019
18
Histopathology of sabra dermatitis: A case report. 61
31033007 2019
19
Combination treatment with lipoteichoic acids isolated from Lactobacillus plantarum and Staphylococcus aureus alleviates atopic dermatitis via upregulation of CD55 and CD59. 61
31454521 2019
20
Clinical Manifestations, Treatment, and Prevention of Acute Irritant Contact Dermatitis Caused by 2,4-Dichloro-5-Methylpyrimidine Exposure in 64 Cases. 61
31688132 2019
21
Challenging a paradigm: skin sensitivity to sodium lauryl sulfate is independent of atopic diathesis. 61
31562780 2019
22
Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. 61
31338881 2019
23
Irritant Contact Dermatitis With Topical Povidone-Iodine Ointment Post Ear Surgery. 61
31547715 2019
24
Botulinum neurotoxin A is an effective treatment for irritant dermatitis caused by ostomy leaks in patients with retractile stomas. 61
30843191 2019
25
Hydrogel containing silibinin nanocapsules presents effective anti-inflammatory action in a model of irritant contact dermatitis in mice. 61
31238095 2019
26
Differences in itch and pain behaviors accompanying the irritant and allergic contact dermatitis produced by a contact allergen in mice. 61
31875186 2019
27
Occupationally Related Nickel Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016. 61
31524759 2019
28
Microfluidics-based skin irritation test using in vitro 3D angiogenesis platform. 61
31431937 2019
29
IL6Rα function in myeloid cells modulates the inflammatory response during irritant contact dermatitis. 61
31165501 2019
30
Four Cases of Perineal Groove-Experience of a Greek Maternity Hospital. 61
31443289 2019
31
Laxative-Induced Contact Dermatitis. 61
29746360 2019
32
Keratinocyte-specific deletion of the IL-6RΑ exacerbates the inflammatory response during irritant contact dermatitis. 61
31158415 2019
33
Bullous irritant contact dermatitis caused by an alcoholic extract from Juglans regia leaves. 61
30740710 2019
34
Phytodermatitis in East and southeast of Turkey: A prospective study. 61
30585511 2019
35
Filaggrin gene mutations in hand eczema patients in the Indian subcontinent: A prospective case-control study. 61
30681730 2019
36
Evaluation of Disposable Protective Garments against Isocyanate Permeation and Penetration from Polyurethane Anticorrosion Coatings. 61
31066890 2019
37
Contact Dermatitis in the Elderly: Predisposing Factors, Diagnosis, and Management. 61
31037642 2019
38
Contact dermatitis and sensitization in professional musicians. 61
30499108 2019
39
"Slime" contact dermatitis: Case report and review of relevant allergens. 61
30865309 2019
40
Cariniana domestica fruit peels present topical anti-inflammatory efficacy in a mouse model of skin inflammation. 61
30617548 2019
41
Impact of water exposure on skin barrier permeability and ultrastructure. 61
30417381 2019
42
Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis. 61
30791982 2019
43
A painful periumbilical rash. 61
31191154 2019
44
Non-glaucoma periocular allergic, atopic, and irritant dermatitis at an academic institution: A retrospective review. 61
29985741 2019
45
A review of non-glove personal protective equipment-related occupational dermatoses reported to EPIDERM between 1993 and 2013. 61
30430597 2019
46
Biotin Is Required for the Zinc Homeostasis in the Skin. 61
31022908 2019
47
Thermography: High sensitivity and specificity diagnosing contact dermatitis in patch testing. 61
30598404 2019
48
Does Adherence to World Health Organization Hand Hygiene Protocols in the Operating Room Have the Potential to Produce Irritant Contact Dermatitis in Anesthesia Providers? 61
31008747 2019
49
Periwound Challenges Improve Patient Satisfaction in Wound Care. 61
31044112 2019
50
Tabernaemontana catharinensis leaves exhibit topical anti-inflammatory activity without causing toxicity. 61
30445106 2019

Variations for Irritant Dermatitis

Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 TSLP TNF IL6 IL4 IL31 IL1B
2
Show member pathways
13.41 TNF IL6 IL4 IL1B IL1A CXCL8
3
Show member pathways
13.38 TNF IL6 IL4 IL31 IL1B IL1A
4
Show member pathways
13.31 TNF IL6 IL4 IL1B IL1A CXCL8
5
Show member pathways
12.87 TNF IL6 IL4 IL1B IL1A CXCL8
6
Show member pathways
12.83 TNF IL6 IL1B IL1A CXCL8 CXCL10
7
Show member pathways
12.78 TNF IL6 IL1B CXCL8 CXCL10
8
Show member pathways
12.62 TNF IL6 IL4 IL1B IL1A
9
Show member pathways
12.62 TNF IL6 IL4 IL1B IL1A
10
Show member pathways
12.51 LORICRIN LCE5A LCE2B KRT16 IVL FLG
11
Show member pathways
12.35 TNF IL6 CXCL8 CXCL10
12
Show member pathways
12.35 TNF IL6 IL4 IL1B
13
Show member pathways
12.34 TNF IL6 IL1B IL1A CXCL8
14
Show member pathways
12.34 TNF IL6 IL4 IL1B CXCL8 CXCL10
15 12.32 TNF IL6 IL1B CXCL8
16
Show member pathways
12.3 TNF IL6 IL4 IL1B IL1A CXCL8
17
Show member pathways
12.28 TNF IL6 IL1A CXCL8
18
Show member pathways
12.28 TNF IL4 IL1B IL1A
19
Show member pathways
12.26 TNF IL6 IL1B IL1A CXCL8
20 12.25 TNF IL6 IL1B CXCL8
21 12.25 TNF IL6 IL1B IL1A
22 12.21 TNF IL6 IL1B IL1A CXCL8
23
Show member pathways
12.15 TNF IL6 IL4 IL1B CXCL8 CXCL10
24
Show member pathways
12.07 TNF IL6 IL4 IL1B
25 12.04 TNF IL6 IL1B CXCL8
26 12 TNF IL6 IL1B CXCL10
27 11.96 IL6 IL1B IL1A CXCL8
28 11.95 TNF IL6 IL1B CXCL8 CD1E
29 11.93 TNF IL6 IL1B IL1A CXCL8
30 11.9 TNF IL6 IL4 IL1B IL1A CXCL8
31 11.88 TNF IL6 IL1B IL1A CXCL8
32 11.83 IL6 IL1B IL1A CXCL8
33 11.83 TSLP TNF IL4 IL1B
34 11.81 IL6 IL4 CXCL8
35 11.79 TNF IL6 IL4 IL1B IL1A CD1E
36
Show member pathways
11.78 TNF IL4 CXCL8
37 11.77 TNF IL6 IL1B IL1A CXCL8
38 11.76 TNF IL6 IL1B
39 11.73 TNF IL6 IL4 IL1B CXCL10
40 11.66 TNF IL6 IL1B CXCL8
41
Show member pathways
11.63 TNF IL6 IL1B IL1A CXCL8
42 11.6 TNF IL6 IL4 IL1B CXCL8
43 11.58 TNF IL6 IL1B CXCL8
44 11.58 TNF IL6 IL4 IL1B IL1A CXCL8
45 11.55 IL6 IL1B IL1A
46 11.54 TSLP IL6 CXCL8
47 11.52 TNF IL6 IL1B IL1A
48 11.42 TNF IL6 IL1B
49 11.4 IL6 IL1B IL1A
50 11.4 TNF IL6 IL1B IL1A

GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TSLP TNF IL6 IL4 IL31 IL1B
2 extracellular space GO:0005615 9.36 TSLP TNF IL6 IL4 IL31 IL1B
3 cornified envelope GO:0001533 9.33 LORICRIN IVL FLG

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.04 TNF IL6 IL4 IL1B IL1A
2 cornification GO:0070268 9.87 LORICRIN KRT16 IVL FLG
3 immune response GO:0006955 9.86 TNF IL6 IL4 IL1B IL1A CXCL8
4 keratinization GO:0031424 9.85 LORICRIN LCE5A LCE2B KRT16 IVL
5 positive regulation of JNK cascade GO:0046330 9.83 TNF IL1B IL1A
6 positive regulation of inflammatory response GO:0050729 9.83 TSLP TNF NLRP10 IL1B
7 positive regulation of T cell proliferation GO:0042102 9.81 IL6 IL4 IL1B
8 neutrophil chemotaxis GO:0030593 9.81 IL1B IL1A CXCL8 CXCL10
9 cellular response to lipopolysaccharide GO:0071222 9.8 TNF IL6 IL1B IL1A CXCL8 CXCL10
10 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.77 TNF IL1B IL1A
11 positive regulation of interleukin-6 secretion GO:2000778 9.75 TNF NLRP10 IL1B
12 positive regulation of vascular endothelial growth factor production GO:0010575 9.73 IL6 IL1B IL1A
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TSLP TNF IL6 IL4
14 negative regulation of neurogenesis GO:0050768 9.72 TNF IL6 IL1B
15 peptide cross-linking GO:0018149 9.71 LORICRIN IVL FLG
16 positive regulation of chemokine production GO:0032722 9.67 TSLP TNF IL6
17 keratinocyte differentiation GO:0030216 9.67 LORICRIN KRT16 IVL FLG
18 positive regulation of chemokine biosynthetic process GO:0045080 9.65 TNF IL1B
19 positive regulation of interleukin-13 production GO:0032736 9.65 TSLP IL4
20 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
21 negative regulation of lipid storage GO:0010888 9.64 TNF IL6
22 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
23 ectopic germ cell programmed cell death GO:0035234 9.62 IL1B IL1A
24 positive regulation of fever generation GO:0031622 9.62 TNF IL1B
25 negative regulation of glucose transmembrane transport GO:0010829 9.61 IL1B FABP5
26 sequestering of triglyceride GO:0030730 9.61 TNF IL1B
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 TNF IL1B
28 fever generation GO:0001660 9.58 IL1B IL1A
29 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
30 inflammatory response GO:0006954 9.56 TNF NLRP10 KRT16 IL6 IL1B IL1A
31 positive regulation of interleukin-6 production GO:0032755 9.55 TSLP TNF IL6 IL1B IL1A
32 cytokine-mediated signaling pathway GO:0019221 9.23 TNF IL6 IL4 IL31 IL1B IL1A

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TSLP TNF IL6 IL4 IL31 IL1B

Sources for Irritant Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
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48 NCI
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50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
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72 UMLS via Orphanet
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