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MCID: IRR003
MIFTS: 53

Irritant Dermatitis

Categories: Immune diseases, Skin diseases
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Aliases & Classifications for Irritant Dermatitis

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MalaCards integrated aliases for Irritant Dermatitis:

Name: Irritant Dermatitis 11 14 16 33
Irritant Contact Dermatitis 11 75 31 33
Primary Irritant Dermatitis 11 33
Dermatitis, Irritant 43 71
Irritant Contact Eczema Due to Exposure to Acids, Alkalis or Other Chemical Irritants 33
Irritant Contact Eczema Due to Friction, Sweating or Contact with Body Fluids 33
Irritant Contact Eczema Due to Topical Medicaments or Antimicrobials 33
Irritant Contact Eczema Due to Plants or Other Vegetable Matter 33
Irritant Contact Eczema Due to Cosmetics or Emollients 33
Irritant Contact Dermatitis, Unspecified Cause 33
Irritant Contact Dermatitis Due to Detergents 33
Irritant Contact Eczema Due to Incontinence 33
Irritant Contact Eczema Due to Wet Work 33
Irritant Contact Eczema Due to Solvents 33
Irritant Contact Eczema Due to Saliva 33
Irritant Contact Eczema Due to Foods 33
Icd - [irritant Contact Dermatitis] 33
Incontinence-Associated Dermatitis 33
Non-Allergic Contact Dermatitis 33
Contact Dermatitis, Irritant 75
Irritant Contact Eczema 33

Classifications:

MalaCards categories:
Anatomical: Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


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Summaries for Irritant Dermatitis

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Disease Ontology: 11 A contact dermatitis that is characterized by a cutaneous inflammatory reaction to repeated contact with an irritant substance, friction, liquid, or adverse temperature that interacts with the skin and often has symptom erythema, edema, scaling, pain, pruritis, or burning sensation.

MalaCards based summary: Irritant Dermatitis, also known as irritant contact dermatitis, is related to decubitus ulcer and occupational dermatitis, and has symptoms including erythema An important gene associated with Irritant Dermatitis is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Sage and Mineral oil have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and neutrophil, and related phenotypes are immune system and digestive/alimentary

Wikipedia: 75 Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...
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Related Diseases for Irritant Dermatitis

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Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 744)
# Related Disease Score Top Affiliating Genes
1 decubitus ulcer 31.3 TNF IL6 IL1B CXCL8
2 occupational dermatitis 31.2 IL31 FLG
3 erysipelas 30.7 TNF IL6 IL1B
4 hemorrhoid 30.5 TNF IL6 IL1B
5 ichthyosis vulgaris 30.3 TSLP LORICRIN IVL FLG
6 chronic ulcer of skin 30.3 TNF IL6 IL1B CXCL8
7 apnea, obstructive sleep 30.3 TNF IL6 IL1B CXCL8
8 skin atrophy 30.2 TNF LORICRIN IL4 IL31 FLG
9 conjunctivitis 30.0 TNF IL6 IL4 IL13 CXCL8
10 hypersensitivity vasculitis 30.0 TNF IL6 CD4
11 dermatophytosis 29.9 TNF IL1B IL17A CD4
12 severe cutaneous adverse reaction 29.9 TNF IL6 CD4
13 vitiligo-associated multiple autoimmune disease susceptibility 1 29.7 TNF IL17A CD4
14 diarrhea 29.7 TNF TAC1 IL6 IL1B IL13 CXCL8
15 bullous pemphigoid 29.7 TNF IVL IL6 IL4 CXCL8 CCL17
16 erythema multiforme 29.6 TNF IL6 IL4 IL1B IL13 CXCL8
17 covid-19 29.6 TNF IL6 IL4 IL1B CXCL8 CXCL10
18 alopecia 29.6 TNF IL6 IL4 IL1B IL1A IL17A
19 candidiasis 29.5 TNF IL6 IL4 IL1B IL1A IL17A
20 urinary tract infection 29.5 TNF IL6 IL1B CXCL8 CD4
21 scabies 29.4 IL4 IL31 IL13 FLG CD4
22 lymphangioma 29.3 TNF IL6 IL1B IL17A CXCL8 CD4
23 primary cutaneous t-cell non-hodgkin lymphoma 29.3 IL4 CXCL10 CD4 CCL17
24 pemphigoid 29.2 TNF IL6 IL4 IL31 IL1B IL17A
25 exanthem 29.1 TNF IL6 IL4 IL1B IL17A CXCL8
26 gingival disease 28.9 TNF IL6 IL4 IL1B IL1A IL17A
27 proteasome-associated autoinflammatory syndrome 1 28.6 TNF IL6 IL4 IL1B IL1A IL17A
28 dermatitis 28.6 TSLP TNF LORICRIN KRT16 IVL IL6
29 crohn's disease 28.6 TNF IL6 IL4 IL1B IL17A IL13
30 fungal infectious disease 28.4 TNF IL6 IL4 IL1B IL1A IL17A
31 urticaria 27.9 TSLP TNF TAC1 IL6 IL4 IL31
32 allergic disease 27.4 TSLP TNF TAC1 IL6 IL4 IL1B
33 contact dermatitis 27.0 TSLP TNF TAC1 LORICRIN KRT16 IVL
34 allergic contact dermatitis 26.8 TSLP TNF LORICRIN IVL IL6 IL4
35 psoriasis 26.8 TNF LORICRIN KRT16 IVL IL6 IL4
36 dermatitis, atopic 26.3 TSLP TNF TAC1 LORICRIN IVL IL6
37 skin disease 26.3 TSLP TNF TAC1 LORICRIN KRT16 IVL
38 phototoxic dermatitis 11.2
39 cholesteatoma of external ear 10.4 IL1A CXCL8
40 clear cell acanthoma 10.3 IVL FLG
41 senile entropion 10.3 TNF CXCL8
42 external pathological resorption 10.3 TNF IL6
43 cicatricial lagophthalmos 10.3 LORICRIN IVL FLG
44 kashin-beck disease 10.3 TNF IL1B
45 periostitis 10.3 TNF IL1B IL1A
46 periodontitis, chronic 10.3 IL6 IL1B
47 paratyphoid fever 10.3 TNF IL1B IL1A
48 ichthyosis, congenital, autosomal recessive 4b 10.3 LORICRIN IVL FLG
49 haemophilus influenzae 10.3 TNF IL1B CXCL8
50 indolent plasma cell myeloma 10.3 IL6 IL1B IL1A

Graphical network of the top 20 diseases related to Irritant Dermatitis:



Diseases related to Irritant Dermatitis
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Symptoms & Phenotypes for Irritant Dermatitis

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Symptoms:

11
  • • erythema

MGI Mouse Phenotypes related to Irritant Dermatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.93 CCL17 CD4 CXCL10 IL13 IL17A IL1A
2 digestive/alimentary MP:0005381 9.86 CD4 IL13 IL17A IL4 IL6 KRT16
3 hematopoietic system MP:0005397 9.73 CCL17 CD4 CXCL10 IL13 IL17A IL1A
4 integument MP:0010771 9.4 CD4 IL13 IL17A IL1A IL1B IL4
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Drugs & Therapeutics for Irritant Dermatitis

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Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sage Approved
2
Mineral oil Approved, Vet_approved 8042-47-5
3
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
4
Clotrimazole Approved, Vet_approved 23593-75-1 2812
5
Zinc cation Approved, Experimental, Investigational 7440-66-6, 23713-49-7 32051
6
Petrolatum Approved, Investigational 8009-03-8
7
Zinc oxide Approved 1314-13-2
8 Kava Approved, Investigational, Nutraceutical 9000-38-8
9
Capric acid Experimental 59906-14-8, 334-48-5 2969
10 Anesthetics
11 Radiation-Protective Agents
12 Sunscreening Agents
13 Emollients
14 Dermatologic Agents
15 Anti-Infective Agents, Local
16
Nickel 7440-02-0 934
17 Anti-Infective Agents
18 Antifungal Agents
19 Protective Agents
20 Pharmaceutical Solutions

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Clinical Study Comparing the Efficacy and Safety of Calmoseptine vs Destin Maximum Strength Diaper Rash Paste in Treatment of Incontinence Associated Dermatitis in Older Children and Adults Completed NCT02080247 Phase 3 Skin care regimen with Calmoseptine ointment;Skin care regimen with Destin ointment
2 Treatment of Incontinence Associated Dermatitis - Automated Unknown status NCT03046810
3 Specific Factors Associated With the Development of Incontinence- Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence: Matched Case Control Study Completed NCT02996357
4 Histopathological Comparison Between Superficial Pressure Ulcers and Incontinence-associated Dermatitis Completed NCT03685929
5 Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery: A Randomised, Controlled Trial Completed NCT03231813
6 Prospective Single Center Randomized Double Blind Controlled Tolerability Trial of Six Hair Cleansing Conditioners Completed NCT03483025
7 An Open Label Study of the Therapeutic Effects of Tetrix Cream in Allergic Contact and Irritant Contact Dermatitis Completed NCT00646867
8 "Developing Of A New Incontinence Care Product, And Investigation Of The Effect Of Its On Perineal Dermatitis in Woman Patients Fecal Incontinence" Completed NCT02991833 Early Phase 1
9 Enhancing SKIN Health and Safety in Aged CARE: An Exploratory Cluster Randomized Pragmatic Trial in Aged Nursing Home Residents (SKINCARE) Completed NCT03824886
10 A Turn and Positioning System and Standardized Incontinence Care Combined With Tailored Repositioning Versus a Standard Repositioning Protocol for Pressure Ulcer Prevention: A Multicenter Prospective Randomized Controlled Clinical Trial and Health Economical Analysis in a Hospital Setting Completed NCT02690753
11 A Clinical Evaluation of 3M Cavilon Advanced Barrier Film for the Treatment of Incontinence Associated Dermatitis (IAD) Completed NCT02724449
12 Comparison Between the Effect of Zinc Oxide and Non-irritant Barrier Film on the Prevention of Incontinence-Associated Dermatitis in Hospitalized Elderly in a Teaching Hospital Completed NCT03309059
13 The Effects of Repeated Exposure to Antiseptics During COVID-19 Pandemic on Skin Parameters Recruiting NCT05276102
14 Controlled Crossover Study to Evaluate the Efficacy of the handLITE LED Device in Treating the Signs of Contact/Irritant Dermatitis of the Hand Recruiting NCT05497921
15 Investigation of Nickel Sensitization After Percutaneous Implantation of Patent Foramen Ovale Occluder; a RandomizEd Trial. Recruiting NCT04713683
16 Comparison of Two Skin Protection Regimes for the Prevention of Incontinence-associated Dermatitis in Geriatric Care: an Exploratory Trial (PID) Recruiting NCT05403762
17 Can the Use of Uricap Female, a New Urine Collecting Device, Lead to Better Care for Women > 75+Years With Urinary Incontinence? Not yet recruiting NCT05275257
18 Adjuvant Effect of Photobiomodulation in the Treatment of Incontinence-associated Dermatitis in Adults - a Randomized Controlled Clinical Trial Not yet recruiting NCT05471180
19 A Total Body Wash Wipe Combined With a Genital Wipe Versus Standard Care (Water and pH Neutral Soap) for Washing of Incontinent Residents in a Long- Term Care Setting: a Multicenter Prospective Randomised Controlled Clinical Trial and Health Economical Analysis in Nursing Homes Terminated NCT02475512
20 EpiCeram for Skin Protection in Healthcare Workers Using Personal Protective Equipment Terminated NCT04793711
21 A Single Center Explorative Study of the Treamtent ofDiabetes Patients With Contact Dermatitits Caused byInsulin Infusion Pump or Glucose Monitor Terminated NCT04909983
22 Multi-Center, Randomized Trial Comparing the Efficacy of 3Mâ„¢ Cavilonâ„¢ Advanced Barrier Film for the Treatment of Incontinence-associated Dermatitis to a Commercially Available Moisture Barrier Terminated NCT02570139
23 Effects of an Advanced Skin Protectant in the Management of Incontinence-associated Dermatitis Compared to Hospital Standard Care Practice: an Exploratory Randomized Controlled Trial Terminated NCT03298113
24 Evaluate the Efficacy of Two Advanced Skin Treatment Regimens in Treating Incontinence-associated Dermatitis: Cluster Randomization Study Terminated NCT04625426

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

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Genetic Tests for Irritant Dermatitis

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Anatomical Context for Irritant Dermatitis

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Organs/tissues related to Irritant Dermatitis:

MalaCards : Skin, T Cells, Neutrophil, Spinal Cord, Liver, Breast, Myeloid
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Publications for Irritant Dermatitis

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Articles related to Irritant Dermatitis:

(show top 50) (show all 1833)
# Title Authors PMID Year
1
Work-related and personal risk factors for occupational contact dermatitis: a systematic review of the literature with meta-analysis. 62
36444496 2022
2
Hand and foot dermatitis in patients referred for patch testing: Analysis of North American Contact Dermatitis Group Data, 2001-2018. 62
35940370 2022
3
[Therapeutic peculiarities in diseases of the nipple skin]. 62
35925215 2022
4
[Occupational Dermatoses in Healthcare Workers during the COVID-19 Pandemic: A Narrative Review]. 62
35766244 2022
5
Bullous irritant contact dermatitis caused by the spitting palm, Euphorbia leuconeura BOISSIER. 62
35895285 2022
6
Povidone-iodine-induced disseminated irritant contact dermatitis. 62
36351674 2022
7
The ability of critical care nurses to identify pressure injury and incontinence-associated dermatitis: A multicentre cross-sectional survey. 62
36266743 2022
8
Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes. 62
36310133 2022
9
A clinical evaluation of a permanent hair dye designed to reduce allergic contact dermatitis and hair damage. 62
35790071 2022
10
Comparison between patch test results of natural dyes and standard allergens in batik workers with occupational contact dermatitis. 62
35771736 2022
11
Comparison of two skin protection regimes for the Prevention of Incontinence-associated Dermatitis in geriatric care (PID): a study protocol for an exploratory randomised controlled pragmatic trial. 62
36175092 2022
12
[Contact dermatitis caused by elastic bands from surgical mask]. 62
34804264 2022
13
Psychometric properties of the Chinese version of the knowledge, attitudes and practices of the incontinence-associated dermatitis questionnaire (C-KAP-IAD-Q) used with Chinese nurses. 62
36089903 2022
14
Is Patch Test Necessary in Children to Solve the Clinical Conundrum of Foot Eczema. 62
34999604 2022
15
Thiamethoxam-Induced Subclinical Onychomadesis. 62
36161079 2022
16
Bacterial invasion into the epidermis of rats with sodium lauryl sulphate-irritated skin increases damage and induces incontinence-associated dermatitis. 62
35916389 2022
17
The prevalence of skin lesions and associated factors in hospitalised adult patients with cancer. 62
36001701 2022
18
Ulcerative vulvar irritant contact dermatitis from eutectic mixture of local anesthetics cream in 2 patients. 62
35769194 2022
19
Profile of Nonvenereal Female Genital Dermatoses: A Cross-Sectional Study From Eastern India. 62
35763612 2022
20
Prevalence and Patterns of Latex Glove Allergy among Healthcare Workers in a Tertiary Care Center In South India - A Cross-Sectional Study. 62
36262582 2022
21
A Structured Skin Care Protocol for Preventing and Treating Incontinence-associated Dermatitis in Critically Ill Patients. 62
35703853 2022
22
Deployed Airbag Causes Bullous Reaction Following a Motor Vehicle Accident. 62
35960968 2022
23
Profile of Dermatological Disorders Among Workers Involved in Fruit Growing Industry of Kashmir Valley in North India. 62
36226016 2022
24
Moisture-Associated Skin Damage: Expanding Practice Based on the Newest ICD-10-CM Codes for Irritant Contact Dermatitis Associated With Digestive Secretions and Fecal or Urinary Effluent From an Abdominal Stoma or Enterocutaneous Fistula. 62
35523238 2022
25
Corrigendum to "Development and validation of the incontinence associated dermatitis knowledge, attitude and practice questionnaire" [J Tissue Viability 29 (2020) 244-251]. 62
34229900 2022
26
The costs, health outcomes and cost-effectiveness of interventions for the prevention and treatment of incontinence-associated dermatitis: A systematic review. 62
35364428 2022
27
Evaluating the Scales Used To Diagnose Incontinence-Associated Dermatitis: A Systematic Review. 62
35442923 2022
28
Irritant contact dermatitis caused by cosmetics containing excessive mercury. 62
35445522 2022
29
Novel insights into contact dermatitis. 62
35183605 2022
30
Quality and clinical applicability of recommendations for incontinence-associated dermatitis: A systematic review of guidelines and consensus statements. 62
35411654 2022
31
CCL2‒CCR2 Signaling in the Skin Drives Surfactant-Induced Irritant Contact Dermatitis through IL-1β‒Mediated Neutrophil Accumulation. 62
34560074 2022
32
Development and Psychometric Testing of a Knowledge Instrument on Incontinence-Associated Dermatitis for Clinicians: The Know-IAD: Erratum. 62
35255061 2022
33
Contact dermatitis and nutrition. 62
35183401 2022
34
Clinician Knowledge of Incontinence-Associated Dermatitis: A Multisite Survey of Healthcare Professionals in Acute and Subacute Settings. 62
35255068 2022
35
Moisture-Associated Skin Damage: Expanding and Updating Practice Based on the Newest ICD-10-CM Codes. 62
35255065 2022
36
Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice. 62
35197329 2022
37
New Key Players in Irritant Contact Dermatitis: Residential Skin Cells and Neutrophils Drive Inflammation. 62
34749986 2022
38
Bullous impetigo-like irritant contact dermatitis caused by perfume. 62
35014095 2022
39
Severe irritant contact dermatitis from olanexidine gluconate and subsequent skin sensitization. 62
34837390 2022
40
Successful management of moisture-, friction-, and trauma-associated skin damage in the pediatric and neonatal population using cyanoacrylate skin protectant. 62
35273126 2022
41
Epidemiological, Clinical, and Allergy Profile of Patients With Atopic Dermatitis and Hand Eczema: Evaluation of the Spanish Contact Dermatitis Registry (REIDAC). 62
35526918 2022
42
The transcriptome of hand eczema assessed by tape stripping. 62
34812515 2022
43
Contact dermatitis due to personal protective equipment use and hygiene practices during the COVID-19 pandemic: A systematic review of case reports. 62
35039780 2022
44
[Pressure sores-A multilayered challenge]. 62
34994853 2022
45
Facial masks vestibulitis: the risk of mismanagement in the COVID-19 pandemic. 62
35075074 2022
46
Skin injuries due to Personal Protective Equipment and preventive measures in the COVID-19 context: an integrative review. 62
35476010 2022
47
An Exploratory Study of the Effects of the pH of Synthetic Urine on Skin Integrity in Healthy Participants. 62
35093947 2022
48
Emerging Links between Microbiome Composition and Skin Immunology in Diaper Dermatitis: A Narrative Review. 62
35053737 2022
49
Occupational contact allergy of construction workers in Greece: Trends during 2009-2018. 62
34510477 2022
50
Skin barrier response to active chlorine hand disinfectant-An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol-based hand rub on healthy skin and eczematous skin. 62
34420240 2022
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Variations for Irritant Dermatitis

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Expression for Irritant Dermatitis

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Search GEO for disease gene expression data for Irritant Dermatitis.
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Pathways for Irritant Dermatitis

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Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.02 CD4 CXCL10 CXCL8 IL13 IL17A IL1A
2
ERK Signaling 64
Show member pathways
 13.9 TNF IL6 IL4 IL1B IL1A IL17A
3
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.66 CCL17 CCL27 CD4 CXCL10 CXCL8 IL13
4
TGF-Beta Pathway 64
Show member pathways
 13.61 TNF IL6 IL4 IL1B IL1A IL17A
5
Akt Signaling 64
Show member pathways
 13.48 TNF IL6 IL4 IL1B IL1A IL17A
6
Cytokine Signaling in Immune system 66
Show member pathways
 13.38 TSLP TNF IL6 IL4 IL31 IL1B
7
PAK Pathway 64
Show member pathways
 13.34 TNF IL6 IL4 IL1B IL1A IL17A
8
Toll-like receptor signaling pathway 74
Show member pathways
 12.9 CXCL10 CXCL8 IL1A IL1B IL6 TNF
9
CCR5 Pathway in Macrophages 64
Show member pathways
 12.86 CXCL8 CXCL10 CD4 CCL27 CCL17
10
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.73 CXCL8 IL13 IL17A IL1A IL1B IL4
11
IL-1 Family Signaling Pathways 65
Show member pathways
 12.67 TNF IL6 IL1B IL1A CXCL8
12
Immune response IL-23 signaling pathway 22
Show member pathways
 12.64 TNF IL6 IL1B IL17A CD4
13
NF-kappaB Signaling 3
12.62 TNF IL4 IL1B IL17A CXCL10
14
Toll-Like receptor Signaling Pathways 65
Show member pathways
 12.53 TNF IL6 IL1B CXCL8
15
Bacterial infections in CF airways 22
Show member pathways
 12.53 TNF IL6 IL4 IL1B IL1A CXCL8
16
Interleukin-1 family signaling 66
Show member pathways
 12.48 IL4 IL1B IL1A IL13
17
Toll Comparative Pathway 64
Show member pathways
 12.38 TNF IL6 IL1B IL1A CXCL8
18
IL-17 Family Signaling Pathways 65
Show member pathways
 12.36 CXCL10 CXCL8 IL17A IL6 TNF
19
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.29 TNF TAC1 IL6 IL1B IL1A IL13
20
Neuroinflammation and glutamatergic signaling 74
12.21 TNF IL6 IL4 IL1B IL1A IL13
21
T-cell activation SARS-CoV-2 74
Show member pathways
 12.19 CD4 IL17A IL4 TNF
22
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 12.11 CXCL8 CXCL10 CCL27 CCL17
23
Spinal cord injury 74
12.08 CXCL10 CXCL8 IL1A IL1B IL4 IL6
24
Hematopoietic Stem Cells and Lineage-specific Markers 65
12.06 TNF IL6 IL4 CD4
25
IL27-mediated signaling events 61
Show member pathways
 12.05 CD4 IL17A IL1B IL6 TNF
26
Senescence and autophagy in cancer 74
12.02 IL6 IL1B IL1A CXCL8
27
Th17 Differentiation 65
Show member pathways
 11.98 IL6 IL4 IL1B IL17A CD4
28
Allograft rejection 74
11.95 TNF IL4 IL1B IL1A IL17A IL13
29
Burn wound healing 74
11.89 TNF IL6 IL1B FLG CXCL8
30
Interleukin-4 and Interleukin-13 signaling 66
11.89 CXCL8 IL13 IL17A IL1A IL1B IL4
31
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.88 IL6 IL17A CXCL8
32
Glucocorticoid receptor regulatory network 61
11.87 IL6 IL4 IL13 CXCL8
33
Dendritic Cells Developmental Lineage Pathway 65
11.85 TNF IL6 IL1B CD4
34
Th17 cell differentiation pathway 74
11.85 IL6 IL4 IL1B IL17A CD4
35
Innate Lymphoid Cells Differentiation 65
11.85 TSLP TNF IL4 IL1B IL17A IL13
36
Lung fibrosis 74
11.81 CXCL8 IL13 IL1B IL4 IL6 TNF
37
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.8 TNF IL6 IL1B IL1A CXCL8
38
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.79 IL6 CXCL8 CD4
39
Inflammatory bowel disease signaling 74
Show member pathways
 11.77 IL13 IL1A IL4 IL6 TNF
40
miRNAs involvement in the immune response in sepsis 74
11.76 TNF IL6 IL1A CXCL8
41
IL 10 signaling pathway 67
11.76 TNF IL6 IL1B IL1A
42
Extrafollicular B cell activation by SARS-CoV-2 74
11.75 TNF IL6 IL4
43
AP-1 transcription factor network 61
11.74 CXCL8 IL4 IL6
44
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 61
Show member pathways
 11.72 TNF IL4 CXCL8
45
Th2 Differentiation 65
11.64 IL4 IL31 IL13 CD4 CCL17
46
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.61 TNF IL6 IL1B IL1A
47
Interleukin-10 signaling 66
11.61 TNF IL6 IL1B IL1A CXCL8 CXCL10
48
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.6 TNF IL6 CXCL8
49
Nonalcoholic fatty liver disease 74
11.55 TNF IL6 IL1A
50
Fibrin complement receptor 3 signaling pathway 74
11.52 TNF IL6 CXCL10
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GO Terms for Irritant Dermatitis

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Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 CCL17 CCL27 CXCL10 CXCL8 IL13 IL17A
2 extracellular space GO:0005615 9.77 CCL17 CCL27 CXCL10 CXCL8 IL13 IL17A
3 cornified envelope GO:0001533 9.76 LORICRIN KRT16 IVL FLG

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.4 CCL27 CD4 CXCL10 CXCL8 IL13 IL1B
2 positive regulation of gene expression GO:0010628 10.39 CXCL8 IL13 IL1A IL1B IL4 IL6
3 chemotaxis GO:0006935 10.28 CXCL8 CXCL10 CCL27 CCL17
4 cell-cell signaling GO:0007267 10.27 CCL17 CCL27 CXCL10 IL17A IL1B TAC1
5 defense response to Gram-positive bacterium GO:0050830 10.26 IL17A IL1B IL6 TNF
6 neutrophil chemotaxis GO:0030593 10.17 IL1B CXCL8 CXCL10 CCL17
7 regulation of insulin secretion GO:0050796 10.16 TNF IL6 IL1B
8 keratinization GO:0031424 10.16 LORICRIN KRT16 IVL IL1A
9 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.13 TNF IL1B IL1A
10 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 10.13 IL4 IL1B IL1A
11 defense response to Gram-negative bacterium GO:0050829 10.13 TSLP IL6 IL17A CD4
12 keratinocyte differentiation GO:0030216 10.13 LORICRIN KRT16 IVL FLG
13 positive regulation of interleukin-2 production GO:0032743 10.12 IL1B IL1A CD4
14 positive regulation of mitotic nuclear division GO:0045840 10.11 TNF IL1B IL1A
15 peptide cross-linking GO:0018149 10.11 FLG IVL LORICRIN
16 positive regulation of vascular endothelial growth factor production GO:0010575 10.1 IL6 IL1B IL1A
17 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.08 TNF IL6 IL17A
18 microglial cell activation GO:0001774 10.08 TNF IL4 IL13
19 negative regulation of neurogenesis GO:0050768 10.07 IL1B IL6 TNF
20 cellular response to lipopolysaccharide GO:0071222 10.06 CXCL10 CXCL8 IL1A IL1B IL6 TNF
21 negative regulation of myoblast differentiation GO:0045662 10.05 TNF CXCL10 CCL17
22 response to lipopolysaccharide GO:0032496 10.05 TNF IL1B IL1A IL13 CXCL10
23 positive regulation of interleukin-10 production GO:0032733 10.03 TSLP IL6 IL4 IL13
24 positive regulation of chemokine production GO:0032722 10.02 TSLP TNF IL6 IL1B
25 positive regulation of glial cell proliferation GO:0060252 10.01 TNF IL6 IL1B
26 inflammatory response GO:0006954 10 CCL17 CXCL10 CXCL8 IL13 IL17A IL1A
27 positive regulation of immature T cell proliferation in thymus GO:0033092 9.98 IL1B IL1A
28 positive regulation of receptor signaling pathway via STAT GO:1904894 9.97 TSLP IL6
29 positive regulation of mononuclear cell migration GO:0071677 9.97 TNF IL4
30 positive regulation of fever generation GO:0031622 9.97 TNF IL1B
31 cellular response to interleukin-17 GO:0097398 9.96 IL1B CXCL10
32 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.96 TSLP TNF IL6 IL4 IL13
33 sequestering of triglyceride GO:0030730 9.94 TNF IL1B
34 positive regulation of neuroinflammatory response GO:0150078 9.93 TNF IL6 IL1B
35 positive regulation of interleukin-6 production GO:0032755 9.93 IL17A IL1A IL1B IL6 TNF TSLP
36 negative regulation of complement-dependent cytotoxicity GO:1903660 9.92 IL4 IL13
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.92 TNF IL1B
38 fever generation GO:0001660 9.91 IL1B IL1A
39 vascular endothelial growth factor production GO:0010573 9.85 TNF IL6 IL1B
40 immune response GO:0006955 9.6 TNF IL6 IL4 IL1B IL1A IL17A

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.66 TSLP TNF IL6 IL4 IL31 IL1B
2 chemokine activity GO:0008009 9.56 CXCL8 CXCL10 CCL27 CCL17
3 cytokine receptor binding GO:0005126 9.46 IL4 IL31 IL13
Sources

Sources for Irritant Dermatitis

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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