Irritant Dermatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IRR003 MIFTS: 47	Irritant Dermatitis Categories: Skin diseases
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Aliases & Classifications for Irritant Dermatitis

MalaCards integrated aliases for Irritant Dermatitis:

Name: Irritant Dermatitis ¹² ¹⁵

Dermatitis, Irritant ⁴⁴ ⁷³

Contact Dermatitis, Irritant ⁷⁶

Irritant Contact Dermatitis ¹²

Primary Irritant Dermatitis ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the skin and subcutaneous tissue

Dermatitis and eczema

Irritant contact dermatitis

Irritant contact dermatitis due to cosmetics

Irritant contact dermatitis due to detergents

Irritant contact dermatitis due to drugs in contact with skin

Irritant contact dermatitis due to food in contact with skin

Irritant contact dermatitis due to oils and greases

Irritant contact dermatitis due to other agents

Irritant contact dermatitis due to other chemical products

Irritant contact dermatitis due to plants, except food

Irritant contact dermatitis due to solvents

Irritant contact dermatitis, unspecified cause

External Ids:

Disease Ontology ¹² DOID:2772

ICD10 ³³ L24 L24.9 L24.0 more

MeSH ⁴⁴ D017453

NCIt ⁵⁰ C27151

SNOMED-CT ⁶⁸ 110979008 200850007

UMLS ⁷³ C0162823

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Summaries for Irritant Dermatitis

MalaCards based summary : Irritant Dermatitis, also known as dermatitis, irritant, is related to burns and dermatitis, atopic. An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Allograft rejection and TRAF Pathway. The drugs Clobetasol and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and eye.

Wikipedia : ⁷⁶ Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

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Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)

#	Related Disease	Score	Top Affiliating Genes
1	burns	30.3	IL1B TNF
2	dermatitis, atopic	30.0	FLG MS4A2 TNF
3	allergic contact dermatitis	30.0	FLG IL1B TNF
4	contact dermatitis	29.1	FLG IL1A IL1B KRT16 TNF
5	sebaceous gland disease	10.7	IER3IP1 IL1A
6	skin conditions	10.7	IL1A TNF
7	dermatitis	10.7
8	discoid lupus erythematosus	10.6	FLG KRT16
9	chronic follicular conjunctivitis	10.6	IL1A IL1B
10	melancholia	10.6	IER3IP1 TNF
11	esophagitis, eosinophilic, 1	10.6	FLG IER3IP1
12	dysentery	10.6	IER3IP1 IL1A
13	multidrug-resistant tuberculosis	10.6	IL1A TNF
14	post-transplant lymphoproliferative disease	10.6	IL1A TNF
15	limbal stem cell deficiency	10.5	IL1A IL1B
16	meningococcemia	10.5	IL1A IL1B
17	glossitis	10.5	IL1B KRT16
18	orofacial granulomatosis	10.5	FLG TNF
19	rosacea	10.5	IER3IP1 TNF
20	systemic onset juvenile idiopathic arthritis	10.5	IL1B TNF
21	staphylococcal toxic shock syndrome	10.5	IL1B TNF
22	autoimmune myocarditis	10.5	IL1B TNF
23	kashin-beck disease	10.5	IL1B TNF
24	vulvar vestibulitis syndrome	10.5	IL1B TNF
25	laryngitis	10.4	IL1B TNF
26	cerebral artery occlusion	10.4	IL1B TNF
27	haemophilus influenzae	10.4	IL1B TNF
28	retinitis pigmentosa 60	10.4	IL1B TNF
29	acute vascular insufficiency of intestine	10.4	IL1B TNF
30	actinic prurigo	10.4	IL1B TNF
31	poems syndrome	10.4	IL1B TNF
32	crohn's colitis	10.4	IL1B TNF
33	central nervous system vasculitis	10.4	IL1B TNF
34	osteosclerotic myeloma	10.4	IL1B TNF
35	cholesteatoma of middle ear	10.4	FLG IL1A KRT16
36	dental pulp disease	10.4	IL1B TNF
37	farmer's lung	10.4	PI3 TNF
38	pustular psoriasis	10.4	PI3 TNF
39	jejunoileitis	10.4	IL1B TNF
40	erysipelas	10.4	PI3 TNF
41	eales disease	10.3	IL1B TNF
42	root resorption	10.3	IL1A IL1B
43	blau syndrome	10.3	IL1B TNF
44	endometritis	10.3	IL1B TNF
45	pachyonychia congenita 1	10.3	FLG KRT16
46	scrub typhus	10.3	IL1B TNF
47	joint disorders	10.3	IL1B TNF
48	middle ear disease	10.3	IL1B TNF
49	epstein-barr virus-associated gastric carcinoma	10.3	FLG TNF
50	pleural disease	10.3	IL1B TNF

Graphical network of the top 20 diseases related to Irritant Dermatitis:

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Symptoms & Phenotypes for Irritant Dermatitis

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Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Clobetasol

Approved, Investigational

Phase 4

25122-46-7, 25122-41-2

32798 5311051

Glycerol

Approved, Investigational

Phase 4

56-81-5

753

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 2

124-94-7

31307

Menthol

Approved

Phase 4

2216-51-5

16666

Zinc

Approved, Investigational

Phase 4,Not Applicable

7440-66-6

23994

Zinc oxide

Approved

Phase 4,Not Applicable

1314-13-2

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 1

22916-47-8

4189

Tocopherol

Approved, Investigational, Nutraceutical

Phase 4

1406-66-2

14986

Vitamin E

Approved, Nutraceutical, Vet_approved

Phase 4

59-02-9

14985

Anti-Inflammatory Agents

Phase 4,Phase 2

Calcineurin Inhibitors

Phase 4

glucocorticoids

Phase 4,Phase 2

Hormone Antagonists

Phase 4,Phase 2,Phase 1

Hormones

Phase 4,Phase 2,Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2,Phase 1

Immunosuppressive Agents

Phase 4,Phase 2

Protective Agents

Phase 4,Phase 2,Not Applicable

triamcinolone acetonide

Phase 4,Phase 2

Triamcinolone diacetate

Phase 4,Phase 2

Triamcinolone hexacetonide

Phase 4,Phase 2

Antipruritics

Phase 4

Dermatologic Agents

Phase 4,Phase 1,Phase 2,Not Applicable

Micronutrients

Phase 4,Not Applicable

Radiation-Protective Agents

Phase 4,Phase 2,Not Applicable

Sunscreening Agents

Phase 4,Phase 2,Not Applicable

Trace Elements

Phase 4,Not Applicable

Antifungal Agents

Phase 4,Phase 1

Anti-Infective Agents

Phase 4,Phase 1

Cytochrome P-450 CYP2C9 Inhibitors

Phase 4

Cytochrome P-450 CYP3A Inhibitors

Phase 4,Phase 1

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 1

Steroid Synthesis Inhibitors

Phase 4,Phase 1

Antioxidants

Phase 4

Tocopherols

Phase 4

Tocotrienols

Phase 4

Vitamins

Phase 4

Aloe

Nutraceutical

Phase 4

Tocotrienol

Investigational, Nutraceutical

Phase 4

6829-55-6

Ephedrine

Approved

Phase 3

299-42-3

9294

Pseudoephedrine

Approved

Phase 3

90-82-4

7028

Timolol

Approved

Phase 3

26839-75-8

33624 5478

Maleic acid

Experimental

Phase 3

110-16-7

444266

Adrenergic Agents

Phase 3

Adrenergic Antagonists

Phase 3

Adrenergic beta-Antagonists

Phase 3

Anti-Arrhythmia Agents

Phase 3

Antihypertensive Agents

Phase 3

Autonomic Agents

Phase 3

Nasal Decongestants

Phase 3

Interventional clinical trials:

(show all 37)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation	Unknown status	NCT00779792	Phase 4	clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
2	Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants	Unknown status	NCT02716415	Phase 4	Calmoseptine Ointment;Destin Maximum Strength 40% Zinc
3	Prospective Two-Year Study to Assess Miconazole Nitrate Resistance in Neonates and Infants	Completed	NCT00702507	Phase 4	0.25 % Miconazole Nitrate Ointment
4	Clinical Study to Evaluate the Efficacy and Safety of Two Marketed Investigational Products in Children With Diaper Rash	Completed	NCT00219466	Phase 4
5	Determination of Safety and Consumers' Satisfaction of Moussik Versus Desitin Creamy Ointment in Diaper Rash Prophylaxis	Withdrawn	NCT01167465	Phase 4
6	Topical Timolol for Superficial Infantile Hemangioma	Unknown status	NCT01685398	Phase 3	0.5% timolol maleate eye drop;Normal saline
7	Mechlorethamine Induced Contact Dermatitis Avoidance Study	Recruiting	NCT03380026	Phase 2	Triamcinolone;Valchlor 0.016 % Topical Gel
8	COLLAGEN CROSS-LINKING WITH ULTRAVIOLET-A IN ASYMMETRIC CORNEAS	Recruiting	NCT03029104	Phase 2	CXLO Corneal Strengthening Solution and UVA Illumination
9	Superficial Basal Cell Cancer's Photodynamic Therapy: Comparing Three Photosensitises: HAL and BF-200 ALA Versus MAL	Recruiting	NCT02367547	Phase 1, Phase 2	Hexylaminolevulinate cream;Aminolevulinic Acid Nano Emulsion;Methylaminolevulinate cream
10	Efficacy and Safety of a Sunscreen Against Porfimer Sodium-induced Phototoxicity to Visible Light	Withdrawn	NCT01256203	Phase 2	Solar Protection Formula SPF® 60
11	A 4-Day Study to Evaluate Phototoxicity of CCP-020 (Diacerein 1%) in Healthy Subjects	Completed	NCT03473184	Phase 1	CCP-020 Diacerein 1% topical ointment;Vehicle
12	A Study Evaluating Skin Irritation, Phototoxicity and Safety After Administration of LEO 90105 on Intact Skin of Healthy Japanese Male Subjects	Completed	NCT01293357	Phase 1	LEO 90105
13	A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity	Completed	NCT00353158	Phase 1	Doxycycline;Voriconazole
14	A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema	Unknown status	NCT01012453	Not Applicable
15	The Use of Coconut Oil for the Prevention and Treatment of Diaper Dermatitis in the NICU Population	Unknown status	NCT02614248	Not Applicable
16	Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery	Completed	NCT03231813	Not Applicable
17	Effect of Tetrix on Alleviation of Burning,Itching Associated With Lesions of Contact Dermatitis	Completed	NCT00646867	Not Applicable
18	Risk Factors for Incontinence-Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence	Completed	NCT02996357
19	BM Collection From NICU Infants for Composition	Completed	NCT02570698
20	BM Characterization Pilot	Completed	NCT03138057
21	Infant Microbiome in Diaper Rash	Completed	NCT02893501
22	Human Phototoxicity Test (823/2016)	Completed	NCT02962856	Not Applicable	BAY987517
23	18348-Human Phototoxicity Test	Completed	NCT02823483	Not Applicable
24	Test the Phototoxicity of Sunscreen Products	Completed	NCT02802930	Not Applicable	SPF 50 Y65 110 (BAY987519);SPF 50 Y51 002 (BAY987519);SPF 15 V27 104 (BAY987519);Sodium chloride [NaCl]
25	Human Phototoxicity Test	Completed	NCT02754102	Not Applicable
26	Human Phototoxicity Test	Completed	NCT02751541	Not Applicable	Sunscreen Sport Spray (BAY987519)
27	Human Phototoxicity Test	Completed	NCT02751489	Not Applicable
28	Human Phototoxicity Test	Completed	NCT02750475	Not Applicable	Sunscreen Sport Lotion (BAY987516)
29	Prospective Single Center Randomized Double Blind Controlled Tolerability Trial of Six Hair Cleansing Conditioners	Recruiting	NCT03483025	Not Applicable
30	Comparison of Barrier Products in the Prevention of Incontinence-associated Dermatitis in Hospitalized Elderly	Recruiting	NCT03309059	Not Applicable
31	Prevention of Phototoxicities in Patients Undergoing Vemurafenib Treatment	Recruiting	NCT03108209	Not Applicable
32	Intervention to Reduce Diaper Need and Increase Use of Pediatric Preventive Care	Not yet recruiting	NCT03490045	Not Applicable
33	Preliminary Evaluation of CASTLE Barrier Prototype UK	Terminated	NCT01530087	Not Applicable
34	Comparison of Wash Wipes and Standard Care in the Prevention of Incontinence-associated Dermatitis in Elderly	Terminated	NCT02475512	Not Applicable
35	CeraVe Cream Compared to Desitin Paste for Treating Diaper Dermatitis in Infants	Terminated	NCT02299206	Not Applicable	CeraVe Baby Diaper Rash Cream;Desitin Maximum Strength Original Paste
36	Vulvar Contact Dermatitis Resulting From Urine Incontinence	Withdrawn	NCT01320046
37	Diaper Distribution in Low-Income Infants	Withdrawn	NCT03425851	Not Applicable

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

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Genetic Tests for Irritant Dermatitis

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Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

⁴¹

Testes, Skin, Eye

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Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 75)

#	Title	Authors	Year
1	Immediate irritant dermatitis from the passionvine hopper (Scolypopa australis). ( 29869388 )	Rademaker M....Sirvid P.J.	2018
2	Preapplication of white petroleum jelly to adjacent skin to prevent aluminum chloride-induced irritant dermatitis. ( 28619576 )	Oliver B....Aires D.	2017
3	Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis. ( 28774591 )	Dai J....Fisher D.E.	2017
4	N-acyl ethanolamide and eicosanoid involvement in irritant dermatitis. ( 26947140 )	Kendall A.C....Nicolaou A.	2016
5	To evaluate the efficacy and safety of &quot;RV2427B&quot; cream in Irritant dermatitis care. ( 23984228 )	Bhat R.M....Ribet V.	2013
6	IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. ( 22966985 )	Lee E.G....Gallucci R.M.	2013
7	Oxidative stress in allergic and irritant dermatitis: from basic research to clinical management. ( 22827837 )	Nakai K....Kubota Y.	2012
8	Allergic and irritant dermatitis: pathogenic and management aspects. ( 22827836 )	Marrakchi S.	2012
9	Hand hygiene compliance and irritant dermatitis: a juxtaposition of healthcare issues. ( 22691060 )	Visscher M.O....Randall Wickett R.	2012
10	Contact irritant dermatitis in Kenya. ( 23472569 )	Nelson T.G....Raitt S.	2012
11	Irritant Dermatitis to Staphylinid Beetle in Indian Troops in Congo. ( 27375320 )	Vasudevan B....Joshi D.C.	2010
12	IL-6, VEGF, KC and RANTES are a major cause of a high irritant dermatitis to phthalic anhydride in C57BL/6 inbred mice. ( 20864798 )	Bae C.J....Hwang D.Y.	2010
13	Povidone iodine irritant dermatitis. ( 20606840 )	Wiwanitkit V.	2010
14	WOC nurse consult: Moist, painful peristomal skin. Chemical irritant dermatitis and pseudoverrucous lesions. ( 20228658 )	Hocevar B.J.	2010
15	Hair highlights and severe acute irritant dermatitis (&quot;burn&quot;) of the scalp. ( 20854194 )	Chan H.P....Maibach H.I.	2010
16	Recurrent cyclic hyperkeratotic eczema after occupational alkali burn: traumatic chronic irritant dermatitis. ( 19489972 )	Nielsen T.K....Kolstad H.A.	2009
17	Contact irritant dermatitis from insect secretions: report of 74 cases in a military unit in Eritrea. ( 19731793 )	Smadi R.M....Ka'abneh A.	2009
18	Treatment with pimecrolimus cream 1% clears irritant dermatitis of the periocular region, face and neck. ( 18937664 )	Mensing C.O....Mensing H.	2008
19	The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. ( 18537995 )	Ortiz P.G....Benfeldt E.	2008
20	Contact and primary irritant dermatitis of the nail unit diagnosis and treatment. ( 17403259 )	Militello G.	2007
21	Occlusive irritant dermatitis: when is &quot;allergic&quot; contact dermatitis not allergic? ( 17366682 )	Miller S....Brodell R.T.	2007
22	Moisturizer effect on irritant dermatitis: an overview. ( 16930228 )	Yokota M....Maibach H.I.	2006
23	Effectiveness of a hand care regimen with moisturizer in manufacturing facilities where workers are prone to occupational irritant dermatitis. ( 15573643 )	Arbogast J.W....Maibach H.I.	2004
24	Irritant dermatitis to detergents in textiles. ( 12882025 )	Matthies W.	2003
25	Irritant dermatitis due to prolonged contact with Oilatum Plus. ( 12534617 )	Loo W.J.	2003
26	Contact irritant dermatitis and anti-pruritic agents: the need to address the itch. ( 12852365 )	Burkhart C.G....Burkhart H.R.	2003
27	Irritant dermatitis, irritancy and its role in allergic contact dermatitis. ( 11952708 )	Smith H.R....McFadden J.P.	2002
28	Sea water or its components alter experimental irritant dermatitis in man. ( 11301639 )	Yoshizawa Y....Maibach H.I.	2001
29	Successfully managing incontinence-related irritant dermatitis across the lifespan. ( 10347509 )	Scardillo J....Aronovitch S.A.	1999
30	Crystal deodorant dermatitis: irritant dermatitis to alum-containing deodorant. ( 10431678 )	Gallego H....Crutchfield C.E.	1999
31	Arachidonic acid metabolism in primary irritant dermatitis produced by patch testing of human skin with surfactants. ( 9875300 )	MA1ller-Decker K....Marks F.	1998
32	Human barrier recovery after acute acetone perturbation: an irritant dermatitis model. ( 9667101 )	Zhai H....Maibach H.I.	1998
33	Kerosene - Induced Acute Irritant Dermatitis (le). ( 20921732 )	Kumar K....Mathur D.	1998
34	Predictive testing in contact dermatitis. Irritant dermatitis. ( 9255475 )	Basketter D.A....York M.	1997
35	What's new in irritant dermatitis. ( 9255463 )	Berardesca E.	1997
36	Pigmented and hyperkeratotic napkin dermatitis: a liquid detergent irritant dermatitis. ( 8864616 )	Patrizi A....Fiorillo L.	1996
37	Sodium hydroxide-induced irritant dermatitis as assessed by computerized elaboration of 20 MHz B-scan images and by TEWL measurement: a method for investigating skin barrier function. ( 7604663 )	Seidenari S....Di Nardo A.	1995
38	Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate. ( 7772476 )	Nicander I....Emtestam L.	1995
39	Acute irritant dermatitis: effect of short-term topical corticoid treatment. ( 7587340 )	Berardesca E....Rabbiosi G.	1995
40	Irritant dermatitis among workers cleaning up a pesticide spill: California 1991. ( 7793424 )	Koo D....Baron R.	1995
41	Irritant dermatitis: experimental aspects. ( 9035907 )	Wilhelm K.P.	1995
42	Irritant dermatitis in the workplace. ( 7923942 )	Elsner P.	1994
43	The causes of irritant dermatitis. ( 8240913 )	Fleming M.G.	1993
44	Moisturizers prevent irritant dermatitis. ( 1350143 )	Hannuksela A....Kinnunen T.	1992
45	Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. ( 1681644 )	Agner T.	1991
46	Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. ( 2365862 )	Wilhelm K.P....Maibach H.I.	1990
47	Increased stratum corneum turnover induced by subclinical irritant dermatitis. ( 2369560 )	Wilhelm K.P....Maibach H.I.	1990
48	Quantification of sodium lauryl sulfate irritant dermatitis in man: comparison of four techniques: skin color reflectance, transepidermal water loss, laser Doppler flow measurement and visual scores. ( 2774663 )	Wilhelm K.P....Maibach H.I.	1989
49	Cumulative irritant dermatitis and abnormal epidermal plasminogen activator activity: what connection? ( 2531125 )	Lotti T....Panconesi E.	1989
50	Susceptibility to cumulative and acute irritant dermatitis. An experimental approach in human volunteers. ( 3180788 )	Lammintausta K....Wilson D.	1988

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Genes for Irritant Dermatitis

Genes related to Irritant Dermatitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IL1A	Interleukin 1 Alpha	Protein Coding	22.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	IER3IP1	Immediate Early Response 3 Interacting Protein 1	Protein Coding	17.45	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	FLG	Filaggrin	Protein Coding	16.62	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	KRT16	Keratin 16	Protein Coding	15.8	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	15.57	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	TNF	Tumor Necrosis Factor	Protein Coding	15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	IL1B	Interleukin 1 Beta	Protein Coding	14.99	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	PI3	Peptidase Inhibitor 3	Protein Coding	14.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	NLRP10	NLR Family Pyrin Domain Containing 10	Protein Coding	14.82	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	LCE2B	Late Cornified Envelope 2B	Protein Coding	6.36	DISEASES inferred ¹⁵
11	OR2B3	Olfactory Receptor Family 2 Subfamily B Member 3	Protein Coding	6.24	DISEASES inferred ¹⁵

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Variations for Irritant Dermatitis

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Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

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Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.68	IL1A IL1B MS4A2 TNF
2	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.3	IL1A IL1B TNF
3	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.19	FLG KRT16 LCE2B PI3
4	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.06	IL1A IL1B TNF
5	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.06	IL1A IL1B TNF
6	Tuberculosis ³⁷	12.04	IL1A IL1B TNF
7	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.03	IL1A IL1B TNF
8	Necroptosis ³⁷ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.01	IL1A IL1B TNF
9	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.96	IL1A IL1B TNF
10	Fluid shear stress and atherosclerosis ³⁷	11.88	IL1A IL1B TNF
11	Osteoclast differentiation ³⁷	11.82	IL1A IL1B TNF
12	Spinal Cord Injury ¹	11.78	IL1A IL1B TNF
13	Interleukin-4 and 13 signaling ⁶⁶	11.74	IL1A IL1B TNF
14	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.67	IL1A IL1B TNF
15	Hematopoietic cell lineage ³⁷	11.64	IL1A IL1B TNF
16	Rheumatoid arthritis ³⁷	11.59	IL1A IL1B TNF
17	Pertussis ³⁷	11.46	IL1A IL1B TNF
18	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.3	IL1A IL1B TNF
19	African trypanosomiasis ³⁷	11.18	IL1B TNF
20	Prion diseases ³⁷	11.18	IL1A IL1B
21	Development and heterogeneity of the ILC family ¹	11.13	IL1B TNF
22	Interleukin-10 signaling ⁶⁶	11.12	IL1A IL1B TNF
23	Antifolate resistance ³⁷	11.11	IL1B TNF
24	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.99	IL1A IL1B TNF
25	Cellular roles of Anthrax toxin ¹	10.91	IL1B TNF
26	LDL Oxidation in Atherogenesis ⁶⁴	10.75	IL1B TNF
27	IL-10 Pathway ⁶⁴	10.68	IL1A IL1B TNF
28	Cytokines and Inflammatory Response ¹	10.28	IL1A IL1B TNF
29	Interleukin-1 processing ⁶⁶	10.21	IL1A IL1B

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GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cornified envelope	GO:0001533	8.8	FLG LCE2B PI3

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 32)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.91	IL1A IL1B MS4A2 TNF
2	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.79	IL1A IL1B TNF
3	cornification	GO:0070268	9.76	FLG KRT16 PI3
4	epidermis development	GO:0008544	9.75	FLG KRT16 LCE2B
5	keratinocyte differentiation	GO:0030216	9.7	FLG KRT16 LCE2B
6	positive regulation of phagocytosis	GO:0050766	9.65	IL1B TNF
7	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.65	IL1A IL1B
8	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.65	IL1B TNF
9	positive regulation of JNK cascade	GO:0046330	9.65	IL1A IL1B TNF
10	positive regulation of cytokine secretion	GO:0050715	9.64	IL1A TNF
11	positive regulation of interleukin-8 production	GO:0032757	9.64	IL1B TNF
12	positive regulation of vascular endothelial growth factor production	GO:0010575	9.63	IL1A IL1B
13	positive regulation of mitotic nuclear division	GO:0045840	9.63	IL1A IL1B
14	positive regulation of interleukin-6 secretion	GO:2000778	9.62	IL1B NLRP10
15	establishment of skin barrier	GO:0061436	9.61	FLG KRT16
16	negative regulation of lipid catabolic process	GO:0050995	9.6	IL1B TNF
17	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.59	IL1B TNF
18	peptide cross-linking	GO:0018149	9.58	FLG LCE2B PI3
19	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.57	IL1A IL1B
20	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.56	IL1B TNF
21	positive regulation of monocyte chemotactic protein-1 production	GO:0071639	9.55	IL1A IL1B
22	positive regulation of chemokine biosynthetic process	GO:0045080	9.54	IL1B TNF
23	ectopic germ cell programmed cell death	GO:0035234	9.51	IL1A IL1B
24	positive regulation of interleukin-6 production	GO:0032755	9.5	IL1A IL1B TNF
25	regulation of establishment of endothelial barrier	GO:1903140	9.49	IL1B TNF
26	positive regulation of fever generation	GO:0031622	9.46	IL1B TNF
27	fever generation	GO:0001660	9.43	IL1A IL1B
28	sequestering of triglyceride	GO:0030730	9.37	IL1B TNF
29	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.33	IL1A IL1B TNF
30	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.26	IL1B TNF
31	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.13	IL1B NLRP10 TNF
32	inflammatory response	GO:0006954	9.1	IL1A IL1B KRT16 MS4A2 NLRP10 TNF

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	9.43	FLG KRT16 LCE2B
2	cytokine activity	GO:0005125	9.33	IL1A IL1B TNF
3	interleukin-1 receptor binding	GO:0005149	8.96	IL1A IL1B
4	structural constituent of epidermis	GO:0030280	8.62	FLG PI3

Sources

Sources for Irritant Dermatitis

¹ BioSystems

² BitterDB

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⁷¹ TGDB

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⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia