Irritant Dermatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: IRR003 MIFTS: 49	Irritant Dermatitis Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Irritant Dermatitis

MalaCards integrated aliases for Irritant Dermatitis:

Name: Irritant Dermatitis ¹² ¹⁵ ¹⁷

Irritant Contact Dermatitis ¹² ³²

Dermatitis, Irritant ⁴³ ⁷¹

Contact Dermatitis, Irritant ⁷⁴

Primary Irritant Dermatitis ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Dermatitis and eczema

Irritant contact dermatitis

Irritant contact dermatitis due to cosmetics

Irritant contact dermatitis due to detergents

Irritant contact dermatitis due to drugs in contact with skin

Irritant contact dermatitis due to food in contact with skin

Irritant contact dermatitis due to oils and greases

Irritant contact dermatitis due to other agents

Irritant contact dermatitis due to other chemical products

Irritant contact dermatitis due to plants, except food

Irritant contact dermatitis due to solvents

Irritant contact dermatitis, unspecified cause

External Ids:

Disease Ontology ¹² DOID:2772

MeSH ⁴³ D017453

NCIt ⁴⁹ C27151

SNOMED-CT ⁶⁷ 110979008

ICD10 ³² L24 L24.0 L24.1 more

EFO ¹⁷ EFO_1000718

UMLS ⁷¹ C0162823

Sources

Summaries for Irritant Dermatitis

Disease Ontology : ¹² A contact dermatitis that is characterized by a cutaneous inflammatory reaction to repeated contact with an irritant substance, friction, liquid, or adverse temperature that interacts with the skin and often has symptom erythema, edema, scaling, pain, pruritis, or burning sensation.

MalaCards based summary : Irritant Dermatitis, also known as irritant contact dermatitis, is related to erysipelas and chronic ulcer of skin, and has symptoms including erythema An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Mineral oil and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are immune system and integument

Wikipedia : ⁷⁴ Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

Sources

Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 490)

#	Related Disease	Score	Top Affiliating Genes
1	erysipelas	30.7	TNF IL6 IL1B
2	chronic ulcer of skin	30.4	TNF IL6 IL1B
3	latex allergy	30.4	TNF IL4 FLG
4	erythema multiforme	30.2	TNF IL6 IL4 CXCL8
5	exanthem	30.2	TNF IL6 IL1B CXCL8
6	sleep apnea	30.2	TNF IL6 IL1B CXCL8
7	scabies	30.1	IL31 IL1A FLG CXCL8
8	conjunctivitis	30.0	TNF IL6 IL4 CXCL8
9	liver disease	30.0	TNF IL6 IL1B IL1A CXCL8
10	urticaria	29.9	TNF IL6 IL4 IL31
11	dermatitis herpetiformis	29.8	TNF IL4 IL31 CXCL8
12	bullous pemphigoid	29.8	TNF IVL IL4 IL31 CXCL8
13	candidiasis	29.8	TNF IL6 IL4 IL1B CXCL8
14	fungal infectious disease	29.5	TNF IL6 IL4 IL1B CXCL8
15	basal cell carcinoma	29.5	TNF KRT16 IVL IL6 IL1B CXCL8
16	allergic hypersensitivity disease	29.3	TSLP TNF IL4 CXCL8 CXCL10
17	proteasome-associated autoinflammatory syndrome 1	28.9	TNF IL6 IL4 IL1B IL1A CXCL8
18	allergic contact dermatitis	28.8	TNF IL6 IL4 IL31 IL1B FLG
19	dermatitis	28.6	TSLP TNF LORICRIN KRT16 IVL IL6
20	contact dermatitis	28.3	TNF KRT16 IVL IL6 IL4 IL31
21	dermatitis, atopic	27.9	TSLP TNF LORICRIN IVL IL6 IL4
22	skin disease	26.7	TNF LORICRIN KRT16 IVL IL6 IL4
23	psoriasis	26.7	TNF LORICRIN KRT16 IVL IL6 IL4
24	physiological polycythemia	10.5	TNF IL1B
25	systemic onset juvenile idiopathic arthritis	10.5	TNF IL1B
26	staphylococcal toxic shock syndrome	10.5	TNF IL1B
27	leukoregulin	10.5	IL1A CXCL8
28	external pathological resorption	10.5	TNF IL6
29	erythrokeratoderma	10.5	LORICRIN IVL FLG
30	scorpion envenomation	10.5	TNF IL6
31	stomach carcinoma in situ	10.5	LORICRIN IVL FLG
32	discoid lupus erythematosus	10.5	KRT16 IVL FLG
33	vulvar vestibulitis syndrome	10.4	TNF IL1B
34	bagassosis	10.4	IL1B CXCL8
35	palladium allergic contact dermatitis	10.4	TNF IL1B
36	kashin-beck disease	10.4	TNF IL1B
37	ichthyosis, congenital, autosomal recessive 4b	10.4	LORICRIN IVL FLG
38	seborrheic dermatitis	10.4	TNF IL1A FLG
39	prosthetic joint infection	10.4	IL6 IL1B
40	periodontitis, chronic	10.4	IL6 IL1B
41	paratyphoid fever	10.4	TNF IL1B IL1A
42	angioimmunoblastic lymphadenopathy with dysproteinemia	10.4	TNF IL6
43	tropical endomyocardial fibrosis	10.4	TNF IL4
44	pachyonychia congenita 1	10.4	LORICRIN KRT16 FLG
45	dermatitis, atopic, 3	10.4	TSLP FLG
46	palmoplantar keratoderma, epidermolytic	10.4	LORICRIN KRT16 FLG
47	ichthyosis vulgaris	10.4	LORICRIN IVL FLG
48	acute transverse myelitis	10.4	IL6 CXCL8
49	tinea corporis	10.4	KRT16 IL31 FLG
50	indolent myeloma	10.4	IL6 IL1B IL1A

Graphical network of the top 20 diseases related to Irritant Dermatitis:

Sources

Symptoms & Phenotypes for Irritant Dermatitis

Symptoms:

¹²

• erythema

MGI Mouse Phenotypes related to Irritant Dermatitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.7	ACKR4 CCR10 CXCL10 FABP5 IL1A IL1B
2	integument	MP:0010771	9.28	CCR10 FABP5 IL1A IL1B IL4 IL6

Sources

Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Mineral oil

Approved, Vet_approved

Phase 4

8042-47-5

Synonyms:

Food Grade Mineral Oil

Heavy Liquid Petrolatum

Heavy mineral oil

Liquid Paraffin

Liquid Petrolatum

Mineral Oil (high Viscosity)

Mineral Oil, Heavy

Paraffin Oil

Paraffin, Liquid

Paraffinum Liquidum

Petrolatum, Liquid

White Mineral Oil

Clobetasol

Approved, Experimental, Investigational

Phase 4

25122-41-2, 25122-46-7

32798 5311051

Synonyms:

(11b,16b)-21-chloro-9-fluoro-11,17-Dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11beta,16beta)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11beta,16beta)-21-chloro-9-fluoro-11,17-Dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(11β,16β)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

(9R,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione

21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate

25122-41-2

AC-1775

AC1L1OG6

AC1NDRJ9

AC1NSJWK

BB_NC-1906

C22H28ClFO4

CHEBI:205919

CHEMBL1201362

CID10341542

CID32797

CID4630419

CID5311051

CID9844480

Clobecort Amex

Clobecort Amex (TN)

clobetasol

Clobetasol

Clobetasol (INN)

Clobetasol [INN:BAN]

Clobetasol 17 propionate

clobetasol 17-propanoate

clobetasol 17-propionate

Clobetasol 17-propionate

Clobetasol propionate

Clobetasol propionate E

Clobetasolum

Clobetasolum [INN-Latin]

Clobex

Clofenazon

Cormax

D07715

Dermovate

EINECS 246-633-8

Embeline

Embeline e

LS-174086

MolPort-005-909-335

NCGC00164580-01

OLUX

STK801976

Temovate

UNII-ADN79D536H

ZINC26892643

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492 6473866

Synonyms:

(-)-FK 506

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone

104987-11-3

109581-93-3 (Hydrate)

15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,

3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN

AC-1182

AC1L1K7H

AC1L97GB

AC1L9IBU

Advagraf

AKOS005145901

Ambap104987-11-3

Ambap5429

Anhydrous tacrolimus

Anhydrous, tacrolimus

BCBcMAP01_000194

Bio-0921

Bio2_000470

Bio2_000950

BRD-K35452788-001-02-1

BSPBio_001279

BSPBio-001279

C01375

C44H69NO10

CCRIS 7124

CHEBI:100924

CHEBI:61049

CHEMBL1200738

CID11158639

CID11556866

CID439492

CID445643

CID5372

CID5472317

CID6426916

CID6436007

CID6473866

CID6536850

CID6610362

CID6912836

CID9832283

CID9853905

CID9918805

CID9940643

CID9963169

Cilag brand OF tacrolimus

CPD000466356

CPD-10016

D08556

DB00864

DivK1c_001040

FK 506

FK5

Fk-506

FK506

FK-506

FR 900506

FR900506

FR-900506

FT-0082660

Fujimycin

Fujisawa brand OF tacrolimus

Graceptor

HMS1362O21

HMS1792O21

HMS1990O21

HMS2051C18

HMS2093M19

HMS503O21

IDI1_001040

IDI1_002225

Janssen brand OF tacrolimus

K506

KBio1_001040

KBio2_000619

KBio2_003187

KBio2_005755

KBio3_001097

KBio3_001098

KBioGR_000619

KBioSS_000619

L 679934

L-679934

LCP-Tacro

LMPK04000003

LS-64247

MLS000759471

MLS001424054

Modigraf

MolPort-003-666-518

NCGC00163470-01

NCGC00163470-02

NCGC00163470-03

NCGC00163470-04

NCGC00179232-01

NChemBio.2007.16-comp1

nchembio.2007.23-comp2

NINDS_001040

NSC717865

Prograf

Prograf (TN)

Prograft

Protopic

Protopy

S5003_Selleck

SAM001246677

SMR000466356

Tacarolimus

tacrolimus

Tacrolimus

Tacrolimus (anhydrous)

Tacrolimus (INN)

Tacrolimus (Prograf?)

Tacrolimus anhydrous

tacrolimus hydrate

Tacrolimus, anhydrous

Tsukubaenolide

UNII-Y5L2157C4J

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Synonyms:

(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11b,16a,17a,21-Tetrahydroxy-9a-fluoro-1,4-pregnadiene-3,20-dione

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione

11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione

11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

124-94-7

4-08-00-03629 (Beilstein Handbook Reference)

83474-03-7

9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d

9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone

9a-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-16a-Hydroxyprednisolone

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9alpha-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-11beta,16alpha,17alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-16alpha-Hydroxyprednisolone

9alpha-Fluoro-16alpha-hydroxyprednisolone

9-alpha-Fluoro-16-alpha-hydroxyprednisolone

9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-16α-hydroxyprednisolone

AC1L1LDH

AC1Q5HJC

AC-2072

Adcortyl

Aristocort

Aristocort A

Aristocort Tablets

Aristogel

Aristospan

Azmacort

Bio-0662

BPBio1_000154

BRD-K77554836-001-03-3

BRN 2341955

BSPBio_000140

C21H27FO6

Celeste

CHEMBL1451

CID31307

Cinolone

Cinolone-T

CL 19823

D00385

D014221

DB00620

Delphicort

droxypregna-1,4-diene-3,20-dione

EINECS 204-718-7

EU-0101179

Fluoxiprednisolone

Fluoxyprednisolone

Flutex

Fougera

HMS1568G22

HMS2090D12

HSDB 3194

ione

Kenacort

Kenacort (TN)

Kenacort-A

Kenacort-Ag

Kenacort-AG

Kenalog

Kenalog in Orabase

Kenalog-10

Kenalog-40

Kenalog-H

Ledercort

Lopac0_001179

LS-698

MLS000028542

MLS001066543

MLS002695935

MolPort-002-528-981

Mycolog

Nasacort

Nasacort Aq

Nasacort Hfa

NCGC00021580-03

NCGC00021580-04

NCGC00021580-05

NCGC00021580-06

NCGC00021580-07

nchembio.2007.53-comp7

NCI60_000750

NSC 13397

NSC13397

Omcilon

Omicilon

Oracort

Oralone

Orion

Polcortolon

Pregna-1,4-diene-3,20-dio

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)

Prestwick_438

Prestwick0_000120

Prestwick1_000120

Prestwick2_000120

Prestwick3_000120

Rodinolone

S1933_Selleck

Sk-Triamcinolone

SK-Triamcinolone

SMP1_000300

SMR000058333

SPBio_002079

T6376_SIGMA

Tiamcinolonum

Tiamcinolonum [INN-Latin]

Triacet

Triacort

Triamcet

Triamcinalone

Triamcinlon

Triamcinolon

Triamcinolona

Triamcinolona [INN-Spanish]

triamcinolone

Triamcinolone

Triamcinolone (JP15/USP/INN)

TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))

Triamcinolone [USAN:INN:BAN:JAN]

Triamcinolone acetonide

Triamcinolone diacetate

Triamcinolone hexacetonide

Triamcinolonum

Triamcinolonum [INN]

Triam-Tablinen

Triatex

Tricortale

Triderm

Trilone

Tri-Nasal

Tristoject

Trymex

UNII-1ZK20VI6TY

Vetalog

Volon

Volon A

WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ

ZINC03882036

Glycerol

Approved, Investigational

Phase 4

56-81-5

753

Synonyms:

1,2,3-propanetriol

1,2,3-Propanetriol

1,2,3-trihydroxypropane

1,2,3-Trihydroxypropane

Bulbold

Cristal

e 422

Emery 916

Glyceol opthalgan

Glycerin

Glycerin, anhydrous

Glycerin,anhydrous

Glycerine

glycérine

Glycerinum

Glyceritol

Glycerol

glycérol

Glycerolum

Glycyl alcohol

Glyrol

Glysanin

Glyzerin

Gro

IFP

Incorporation factor

Mackstat H 66

Monoctanoin component D

Oelsuess

Ölsüß

Osmoglyn

Pricerine 9091

Propanetriol

RG-S

Trihydroxypropane

Tryhydroxypropane

Apremilast

Approved, Investigational

Phase 4

608141-41-9

11561674

Synonyms:

Apremilast

Aprémilast

Apremilast (USAN)

Apremilastum

CC-10004

CHEBI:558773

CHEMBL514800

CID11561674

D08860

N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide

N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

Emollients

Phase 4

Hormones

Phase 4

Triamcinolone diacetate

Phase 4

Hormone Antagonists

Phase 4

Triamcinolone hexacetonide

Phase 4

Protective Agents

Phase 4

triamcinolone acetonide

Phase 4

glucocorticoids

Phase 4

Trace Elements

Phase 3

Vitamins

Phase 3

Mitogens

Phase 3

Provitamins

Phase 3

Nutrients

Phase 3

Micronutrients

Phase 3

Anesthetics

Interventional clinical trials:

(show all 15)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Experimentally Induced Skin Irritation	Unknown status	NCT00779792	Phase 4	clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
2	An Open-label, Single-Arm Pilot Study Investigating the Efficacy and Safety of Apremilast for the Treatment of Moderate to Severe Chronic Hand Dermatitis	Terminated	NCT03741933	Phase 4	Apremilast 30mg
3	Phase III Randomized Double-Blind Trial of Bepanthen® Cream Versus Cetomacrogol Cream in the Prevention of Papulopustular Eruption in Patients Receiving Epidermal Growth Factor Receptor Inhibitors (EGFRI): BeCet	Completed	NCT01136005	Phase 3
4	Bariederm Cream in Chronic Contact Dermatitis	Unknown status	NCT02026700
5	Chemokine Expression in Nummular Dermatitis and Atopic Dermatitis	Unknown status	NCT01311986
6	Hand Eczema Trial: A Randomised Clinical Trial of the Effect of Classification and Individual Counselling Among Health Care Workers With Hand Eczema	Unknown status	NCT01012453
7	Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery: A Randomised, Controlled Trial	Completed	NCT03231813
8	Prospective Single Center Randomized Double Blind Controlled Tolerability Trial of Six Hair Cleansing Conditioners	Completed	NCT03483025
9	Specific Factors Associated With the Development of Incontinence- Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence: Matched Case Control Study	Completed	NCT02996357
10	An Open Label Study of the Therapeutic Effects of Tetrix Cream in Allergic Contact and Irritant Contact Dermatitis	Completed	NCT00646867
11	Histopathological Comparison Between Superficial Pressure Ulcers and Incontinence-associated Dermatitis	Not yet recruiting	NCT03685929
12	A Total Body Wash Wipe Combined With a Genital Wipe Versus Standard Care (Water and pH Neutral Soap) for Washing of Incontinent Residents in a Long- Term Care Setting: a Multicenter Prospective Randomised Controlled Clinical Trial and Health Economical Analysis in Nursing Homes	Terminated	NCT02475512
13	Peristomal Skin Irritation: A Preliminary Evaluation of the CASTLE Barrier Prototype for People With Intestinal Stomas	Terminated	NCT01530087
14	Vulvar Contact Dermatitis Resulting From Urine Incontinence: Prevalence, Characteristics and Risk Factors	Withdrawn	NCT01320046
15	Evaluation of the Therapeutic Effect and Local Tolerability of Elidel® Cream 1% (Pimecrolimus) in Chronic Discoid Lupus Erythematosus (dLE) or Subacute Cutaneous Lupus Erythematosus (scLE)	Withdrawn	NCT00222183		Elidel (pimecrolimus)

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

Sources

Genetic Tests for Irritant Dermatitis

Sources

Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

⁴⁰

Skin, Testes, T Cells, Neutrophil, Liver, Breast, Myeloid

Sources

Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 1418)

#	Title	Authors	PMID	Year
1	Adverse cutaneous reaction to diabetic glucose sensors and insulin pumps: Irritant contact dermatitis or allergic contact dermatitis? ⁶¹	Herman A...Baeck M	32212168	2020
2	Frequent handwashing amidst the COVID-19 outbreak: prevention of hand irritant contact dermatitis and other considerations. ⁶¹	Abtahi-Naeini B	32346616	2020
3	12-year data on dermatologic cases in the Finnish Register of Occupational Diseases I: Distribution of different diagnoses and main causes of allergic contact dermatitis. ⁶¹	Aalto-Korte K...Pesonen M	32037572	2020
4	The effect of the "stay-at-home" policy on requests for dermatology outpatient clinic visits after the COVID-19 outbreak. ⁶¹	Kutlu O...Khachemoune A	32401401	2020
5	Contact Dermatitis Associated With Nail Care Products: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001-2016. ⁶¹	Warshaw EM...Zirwas MJ	32355091	2020
6	CD44 expression in human skin: High expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls. ⁶¹	Lugovic-Mihic L...Bukvic I	31900953	2020
7	A case of irritant contact dermatitis and suspected linagliptin-induced koebnerized bullous pemphigoid. ⁶¹	Ambur A...Smith E	32258308	2020
8	Anogenital Dermatitis in Men Who Have Sex with Men. ⁶¹	McCleskey PE	32115132	2020
9	Irritant contact dermatitis due to Euphorbia trigona. ⁶¹	Elmas OF	31782156	2020
10	Optimizing the Biodistribution of Radiofluorinated Barbiturate Tracers for Matrix Metalloproteinase Imaging by Introduction of Fluorescent Dyes as Pharmacokinetic Modulators. ⁶¹	Schwegmann K...Breyholz HJ	32181649	2020
11	Comparison of safety of loop ileostomy and loop transverse colostomy for low-lying rectal cancer patients undergoing anterior resection: A retrospective, single institution, propensity score-matched study. ⁶¹	Sun X...Xiao Y	32199033	2020
12	Irritant contact dermatitis after a curious therapeutic use of oregano essential oil. ⁶¹	Lauriola MM...Corazza M	32232859	2020
13	Hand eczema treatment: Change behaviour with text messaging, a randomized trial. ⁶¹	Erdil D...Gurel MS	31794053	2020
14	Anti-inflammatory effect of lanoconazole on 12-O-tetradecanoylphorbol-13-acetate- and 2,4,6-trinitrophenyl chloride-induced skin inflammation in mice. ⁶¹	Nakamura A...Matsumoto T	31724251	2020
15	Dyshidrosiform Bullous Pemphigoid: Case Reports and Review. ⁶¹	Cohen PR	32064205	2020
16	The Efficacy of Colloidal Oatmeal Cream 1% as Add-on Therapy in the Management of Chronic Irritant Hand Eczema: A Double-Blind Study. ⁶¹	Sobhan M...Mehrpooya M	32273745	2020
17	Severe irritant reaction following sequential waxing and use of a chemical depilatory cream in an adolescent. ⁶¹	Kiene J...DeKlotz CMC	31769049	2020
18	Oral administration of whole dihomo-γ-linolenic acid-producing yeast suppresses allergic contact dermatitis in mice. ⁶¹	Watanabe N...Uemura H	31532348	2020
19	Management of incontinence-associated dermatitis patients using a skin protectant in acute care: a case series. ⁶¹	Acton C...Browning P	31930942	2020
20	Does Adherence to World Health Organization Hand Hygiene Protocols in the Operating Room Have the Potential to Produce Irritant Contact Dermatitis in Anesthesia Providers? ⁶¹	Birnbach DJ...Lindsey SF	31743176	2019
21	Possible roles of basophils in chronic itch. ⁶¹	Hashimoto T...Yosipovitch G	29894005	2019
22	Oleylamine-induced pustular irritant contact dermatitis. ⁶¹	Yoo S...Lee J	31389016	2019
23	Tandem repeated irritation test (TRIT) studies and clinical relevance: Post 2006. ⁶¹	Reddy R...Maibach H	29886752	2019
24	Irritant contact dermatitis caused by a shower cream used as a leave-on product. ⁶¹	Opstrup MS...Yazdanyar S	31265145	2019
25	Facial Dermatitis in Male Patients Referred for Patch Testing: Retrospective Analysis of North American Contact Dermatitis Group Data, 1994 to 2016. ⁶¹	Warshaw EM...Zirwas MJ	31774459	2019
26	Triclosen and Its Alternatives in Antibacterial Soaps. ⁶¹	Rundle CW...Dunnick CA	31688130	2019
27	Fiberglass dermatitis: clinical presentations, prevention, and treatment - a review of literatures. ⁶¹	Camacho I...Tosti A	30816574	2019
28	Histopathology of sabra dermatitis: A case report. ⁶¹	Esmaeili A...Crowson AN	31033007	2019
29	Clinical Manifestations, Treatment, and Prevention of Acute Irritant Contact Dermatitis Caused by 2,4-Dichloro-5-Methylpyrimidine Exposure in 64 Cases. ⁶¹	Fan W...Wang L	31688132	2019
30	Combination treatment with lipoteichoic acids isolated from Lactobacillus plantarum and Staphylococcus aureus alleviates atopic dermatitis via upregulation of CD55 and CD59. ⁶¹	Kim Y...Chung DK	31454521	2019
31	In Vivo Reflectance Confocal Microscopy: Emerging Role in Noninvasive Diagnosis and Monitoring of Eczematous Dermatoses. ⁶¹	Maarouf M...Shi VY	31202471	2019
32	Challenging a paradigm: skin sensitivity to sodium lauryl sulfate is independent of atopic diathesis. ⁶¹	Heetfeld AB...Buhl T	31562780	2019
33	Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. ⁶¹	Fukuyama T...Fukami K	31338881	2019
34	Irritant Contact Dermatitis With Topical Povidone-Iodine Ointment Post Ear Surgery. ⁶¹	Singh A...Haq M	31547715	2019
35	Hydrogel containing silibinin nanocapsules presents effective anti-inflammatory action in a model of irritant contact dermatitis in mice. ⁶¹	Rigon C...Cruz L	31238095	2019
36	Differences in itch and pain behaviors accompanying the irritant and allergic contact dermatitis produced by a contact allergen in mice. ⁶¹	Zhang Z...LaMotte RH	31875186	2019
37	Occupationally Related Nickel Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016. ⁶¹	Warshaw EM...Taylor JS	31524759	2019
38	Botulinum neurotoxin A is an effective treatment for irritant dermatitis caused by ostomy leaks in patients with retractile stomas. ⁶¹	Bhoyrul B...Lyon C	30843191	2019
39	Microfluidics-based skin irritation test using in vitro 3D angiogenesis platform. ⁶¹	Jusoh N...Jeon NL	31431937	2019
40	IL6Rα function in myeloid cells modulates the inflammatory response during irritant contact dermatitis. ⁶¹	Frempah B...Gallucci RM	31165501	2019
41	Four Cases of Perineal Groove-Experience of a Greek Maternity Hospital. ⁶¹	Boutsikou T...Iacovidou N	31443289	2019
42	Laxative-Induced Contact Dermatitis. ⁶¹	Melvin JE...Hickey RW	29746360	2019
43	Keratinocyte-specific deletion of the IL-6RΑ exacerbates the inflammatory response during irritant contact dermatitis. ⁶¹	Frempah B...Gallucci RM	31158415	2019
44	Bullous irritant contact dermatitis caused by an alcoholic extract from Juglans regia leaves. ⁶¹	Corazza M...Borghi A	30740710	2019
45	Filaggrin gene mutations in hand eczema patients in the Indian subcontinent: A prospective case-control study. ⁶¹	Handa S...De D	30681730	2019
46	Phytodermatitis in East and southeast of Turkey: A prospective study. ⁶¹	An I...Ozturk M	30585511	2019
47	Contact Dermatitis in the Elderly: Predisposing Factors, Diagnosis, and Management. ⁶¹	Lima AL...Elsner P	31037642	2019
48	Contact dermatitis and sensitization in professional musicians. ⁶¹	Kraft M...IVDK	30499108	2019
49	"Slime" contact dermatitis: Case report and review of relevant allergens. ⁶¹	Anderson LE...Yu J	30865309	2019
50	Cariniana domestica fruit peels present topical anti-inflammatory efficacy in a mouse model of skin inflammation. ⁶¹	Milani GB...Oliveira SM	30617548	2019

Sources

Genes for Irritant Dermatitis

Genes related to Irritant Dermatitis (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IL1A	Interleukin 1 Alpha	Protein Coding	12.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	FLG	Filaggrin	Protein Coding	7.29	DISEASES inferred ¹⁵
3	LORICRIN	Loricrin Cornified Envelope Precursor Protein	Protein Coding	6.34	DISEASES inferred ¹⁵
4	IVL	Involucrin	Protein Coding	6.23	DISEASES inferred ¹⁵
5	KRT16	Keratin 16	Protein Coding	6.06	DISEASES inferred ¹⁵
6	IL1B	Interleukin 1 Beta	Protein Coding	5.99	DISEASES inferred ¹⁵
7	TNF	Tumor Necrosis Factor	Protein Coding	5.87	DISEASES inferred ¹⁵
8	OR2B3	Olfactory Receptor Family 2 Subfamily B Member 3	Protein Coding	5.82	DISEASES inferred ¹⁵
9	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	5.79	DISEASES inferred ¹⁵
10	LCE2B	Late Cornified Envelope 2B	Protein Coding	5.58	DISEASES inferred ¹⁵
11	IL31	Interleukin 31	Protein Coding	5.52	DISEASES inferred ¹⁵
12	IL6	Interleukin 6	Protein Coding	5.51	DISEASES inferred ¹⁵
13	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	5.5	DISEASES inferred ¹⁵
14	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	5.48	DISEASES inferred ¹⁵
15	IL4	Interleukin 4	Protein Coding	5.45	DISEASES inferred ¹⁵
16	CCR10	C-C Motif Chemokine Receptor 10	Protein Coding	5.34	DISEASES inferred ¹⁵
17	LCE5A	Late Cornified Envelope 5A	Protein Coding	5.31	DISEASES inferred ¹⁵
18	ACKR4	Atypical Chemokine Receptor 4	Protein Coding	5.24	DISEASES inferred ¹⁵
19	FABP5	Fatty Acid Binding Protein 5	Protein Coding	5.24	DISEASES inferred ¹⁵
20	NLRP10	NLR Family Pyrin Domain Containing 10	Protein Coding	5.23	DISEASES inferred ¹⁵

Sources

Variations for Irritant Dermatitis

Sources

Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

Sources

Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.69	TSLP TNF IL6 IL4 IL31 IL1B
2	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.43	TNF IL6 IL4 IL1B IL1A CXCL8
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.38	TNF IL6 IL4 IL31 IL1B IL1A
4	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.31	TNF IL6 IL4 IL1B IL1A CXCL8
5	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.87	TNF IL6 IL4 IL1B IL1A CXCL8
6	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.84	TNF IL6 IL1B IL1A CXCL8 CXCL10
7	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²² NOD-like Receptor Signaling Pathways ⁶⁴	12.74	TNF IL6 IL1B IL1A CXCL8
8	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.63	TNF IL6 IL4 IL1B IL1A
9	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.62	TNF IL6 IL4 IL1B IL1A
10	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	12.5	LORICRIN LCE5A LCE2B KRT16 IVL FLG
11	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.35	TNF IL6 IL4 IL1B
12	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.35	TNF IL6 IL1B IL1A CXCL8
13	Salmonella infection (KEGG) ³⁶	12.33	TNF IL6 IL1B CXCL8
14	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.32	TNF IL6 IL4 IL1B CXCL8 CXCL10
15	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.31	TNF IL6 IL4 IL1B IL1A CXCL8
16	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.31	TNF IL6 CXCL8 CXCL10 CCR10 ACKR4
17	Pathogenic Escherichia coli infection ³⁶	12.29	TNF IL6 IL1B CXCL8
18	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.28	TNF IL6 IL1A CXCL8
19	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.28	TNF IL4 IL1B IL1A
20	NOD-like receptor signaling pathway ³⁶	12.26	TNF IL6 IL1B CXCL8
21	Tuberculosis ³⁶	12.25	TNF IL6 IL1B IL1A
22	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.22	TNF IL6 IL1B IL1A CXCL8
23	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.13	TNF IL6 IL4 IL1B CXCL8 CXCL10
24	Yersinia infection ³⁶	12.05	TNF IL6 IL1B CXCL8
25	TNF signaling pathway ³⁶	12	TNF IL6 IL1B CXCL10
26	Senescence and Autophagy in Cancer ¹	11.97	IL6 IL1B IL1A CXCL8
27	Amoebiasis ³⁶	11.95	TNF IL6 IL1B CXCL8
28	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.93	TNF IL6 IL1B IL1A CXCL8
29	Hematopoietic cell lineage ³⁶	11.92	TNF IL6 IL4 IL1B IL1A
30	Interleukin-4 and 13 signaling ⁶⁵	11.86	TNF IL6 IL4 IL1B IL1A CXCL8
31	Rheumatoid arthritis ³⁶	11.84	TNF IL6 IL1B IL1A CXCL8
32	Innate Lymphoid Cells Differentiation ⁶⁴	11.83	TSLP TNF IL4 IL1B
33	Glucocorticoid receptor regulatory network ¹	11.81	IL6 IL4 CXCL8
34	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.77	TNF IL4 CXCL8
35	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.76	TNF IL6 IL1B
36	Pertussis ³⁶	11.74	TNF IL6 IL1B IL1A CXCL8
37	Legionellosis ³⁶	11.65	TNF IL6 IL1B CXCL8
38	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.6	TNF IL6 IL1B IL1A CXCL8
39	Malaria ³⁶	11.58	TNF IL6 IL1B CXCL8
40	Spinal Cord Injury ¹	11.58	TNF IL6 IL4 IL1B IL1A CXCL8
41	Lung fibrosis ¹	11.57	TNF IL6 IL4 IL1B CXCL8
42	Hematopoietic Stem Cell Differentiation ¹	11.55	IL6 IL1B IL1A
43	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.54	TSLP IL6 CXCL8
44	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.51	TNF IL6 IL1B IL1A
45	African trypanosomiasis ³⁶	11.42	TNF IL6 IL1B
46	Prion diseases ³⁶	11.4	IL6 IL1B IL1A
47	IL-10 Pathway ⁶³	11.39	TNF IL6 IL1B IL1A
48	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	11.38	IVL IL6 CXCL8
49	Antifolate resistance ³⁶	11.33	TNF IL6 IL1B
50	Development and heterogeneity of the ILC family ¹	11.16	TSLP TNF IL6 IL4 IL1B

Sources

GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.65	TSLP TNF IL6 IL4 IL31 IL1B
2	cornified envelope	GO:0001533	9.33	LORICRIN IVL FLG
3	extracellular space	GO:0005615	9.32	TSLP TNF IL6 IL4 IL31 IL1B

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 39)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.3	TSLP OR2B3 IL6 IL4 IL1B CXCL8
2	positive regulation of gene expression	GO:0010628	10.07	TNF IL6 IL4 IL1B IL1A
3	chemotaxis	GO:0006935	9.94	CXCL8 CXCL10 CCR10 ACKR4
4	keratinization	GO:0031424	9.91	LORICRIN LCE5A LCE2B KRT16 IVL
5	cornification	GO:0070268	9.88	LORICRIN KRT16 IVL FLG
6	calcium-mediated signaling	GO:0019722	9.85	CXCL8 CCR10 ACKR4
7	neutrophil chemotaxis	GO:0030593	9.85	IL1B CXCL8 CXCL10
8	positive regulation of inflammatory response	GO:0050729	9.85	TSLP TNF NLRP10 IL1B
9	positive regulation of T cell proliferation	GO:0042102	9.83	IL6 IL4 IL1B
10	chemokine-mediated signaling pathway	GO:0070098	9.8	CXCL8 CXCL10 CCR10 ACKR4
11	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.79	TNF IL1B IL1A
12	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.78	IL4 IL1B IL1A
13	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.78	TSLP TNF IL6 IL4
14	inflammatory response	GO:0006954	9.76	TNF NLRP10 KRT16 IL6 IL1B IL1A
15	positive regulation of vascular endothelial growth factor production	GO:0010575	9.75	IL6 IL1B IL1A
16	negative regulation of neurogenesis	GO:0050768	9.74	TNF IL6 IL1B
17	peptide cross-linking	GO:0018149	9.73	LORICRIN IVL FLG
18	cellular response to lipopolysaccharide	GO:0071222	9.73	TNF IL6 IL1B IL1A CXCL8 CXCL10
19	positive regulation of chemokine production	GO:0032722	9.71	TSLP TNF IL6
20	keratinocyte differentiation	GO:0030216	9.71	LORICRIN KRT16 IVL FLG
21	positive regulation of glial cell proliferation	GO:0060252	9.7	TNF IL6 IL1B
22	negative regulation of lipid storage	GO:0010888	9.67	TNF IL6
23	positive regulation of interleukin-13 production	GO:0032736	9.67	TSLP IL4
24	positive regulation of interleukin-6 production	GO:0032755	9.67	TSLP TNF IL6 IL1B
25	regulation of establishment of endothelial barrier	GO:1903140	9.66	TNF IL1B
26	ectopic germ cell programmed cell death	GO:0035234	9.65	IL1B IL1A
27	positive regulation of mononuclear cell migration	GO:0071677	9.65	TNF IL4
28	positive regulation of STAT cascade	GO:1904894	9.64	TSLP IL6
29	positive regulation of fever generation	GO:0031622	9.63	TNF IL1B
30	negative regulation of glucose transmembrane transport	GO:0010829	9.63	IL1B FABP5
31	positive regulation of chemokine biosynthetic process	GO:0045080	9.63	TNF IL4 IL1B
32	positive regulation of immature T cell proliferation in thymus	GO:0033092	9.62	IL1B IL1A
33	sequestering of triglyceride	GO:0030730	9.62	TNF IL1B
34	positive regulation of interleukin-6 secretion	GO:2000778	9.62	TNF NLRP10 IL1B IL1A
35	positive regulation of neuroinflammatory response	GO:0150078	9.61	TNF IL6 IL1B
36	immune response	GO:0006955	9.61	TNF IL6 IL4 IL1B IL1A CXCL8
37	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.6	TNF IL1B
38	fever generation	GO:0001660	9.59	IL1B IL1A
39	cytokine-mediated signaling pathway	GO:0019221	9.23	TNF IL6 IL4 IL31 IL1B IL1A

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.28	TSLP TNF IL6 IL4 IL31 IL1B

Sources

Sources for Irritant Dermatitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia