Ischemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ISC004 MIFTS: 60	Ischemia Categories: Blood diseases, Cardiovascular diseases, Metabolic diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Ischemia

MalaCards integrated aliases for Ischemia:

Name: Ischemia ¹¹ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹ ⁷⁵

Acute Coronary Syndrome ⁷¹

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:326

MeSH ⁴³ D007511

NCIt ⁴⁹ C34738

SNOMED-CT ⁶⁸ 52674009

EFO ¹⁶ EFO_0000556

UMLS ⁷¹ C0022116 C0948089

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Summaries for Ischemia

Disease Ontology: ¹¹ A vascular disease that is characterized by a restriction in blood supply to tissues.

MalaCards based summary: Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including muscle weakness, polydipsia and angina pectoris. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Tenecteplase and Metformin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: ⁷⁵ Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the... more...

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Related Diseases for Ischemia

Diseases related to Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2033)

#	Related Disease	Score	Top Affiliating Genes
1	limb ischemia	33.3	VEGFA NOS3 HIF1A CXCL12 ACE
2	lipoprotein quantitative trait locus	33.2	VEGFA TLR2 PON1 NOS3 HIF1A CASP3
3	retinal ischemia	33.1	VEGFA HMOX1 HIF1A EPO CASP3
4	cerebral artery occlusion	32.8	VEGFA HMOX1 HIF1A CASP3
5	vascular disease	32.7	VEGFA SOD1 PON1 NOS3 HMOX1 CASP3
6	myocardial infarction	32.5	VEGFA TLR2 SOD2 SOD1 PON1 NOS3
7	microvascular complications of diabetes 5	32.3	VEGFA SOD2 SOD1 PON1 NOS3 HIF1A
8	myocardial stunning	32.2	SOD1 NOS3 ADORA3 ADORA1 ACE
9	carotid artery occlusion	32.2	VEGFA EPO CASP3
10	peripheral vascular disease	32.2	VEGFA NOS3 EPO ACE
11	aortic dissection	32.2	NOS3 HIF1A ACE
12	stroke, ischemic	32.2	VEGFA SOD2 PON1 NOS3 CXCL12 CDK5
13	brain edema	32.2	VEGFA SOD1 HMOX1 HIF1A
14	exudative vitreoretinopathy 1	32.1	VEGFA NOS3 HIF1A EPO CASP3
15	microvascular complications of diabetes 1	32.1	VEGFA HIF1A CXCL12
16	nephrosclerosis	32.1	VEGFA HIF1A CASP3 ACE
17	aortic aneurysm, familial thoracic 1	32.0	VEGFA NOS3 HIF1A ACE
18	intracranial berry aneurysm	32.0	VEGFA NOS3 HMOX1 EPO CASP3
19	coronary stenosis	31.9	PON1 CXCL12 ACE
20	peripheral artery disease	31.9	VEGFA NOS3 ACE
21	cerebrovascular disease	31.9	PON1 CASP3 APP ACE
22	hyperglycemia	31.8	TLR2 SOD2 SOD1 PRKAA2 NOS3 HIF1A
23	asphyxia neonatorum	31.8	HIF1A EPO CASP3
24	acute myocardial infarction	31.8	VEGFA PON1 NOS3 ACE
25	end stage renal disease	31.7	VEGFA SOD2 PON1 EPO ACE
26	pulmonary edema	31.7	NOS3 HIF1A EPO ACE
27	arteriosclerosis	31.6	PON1 HMOX1 HIF1A CXCL12 ACE
28	chronic kidney disease	31.6	SOD1 PON1 NOS3 EPO ACE
29	kidney disease	31.6	VEGFA PON1 NOS3 HMOX1 HIF1A EPO
30	pre-eclampsia	31.6	VEGFA SOD1 PON1 NOS3 HMOX1 HIF1A
31	congestive heart failure	31.6	VEGFA EPO ADORA1 ACE
32	toxic encephalopathy	31.5	SOD1 HMOX1 CDK5 CASP3 APP
33	carotid stenosis	31.5	VEGFA NOS3 ACE
34	heart disease	31.5	VEGFA TLR2 SOD2 SOD1 PON1 NOS3
35	atherosclerosis susceptibility	31.5	PON1 NOS3 HMOX1 ACE
36	cerebral palsy	31.4	SOD1 PON1 NOS3 HIF1A EPO
37	retinal vascular disease	31.4	VEGFA NOS3 HIF1A CASP3 ACE
38	vascular dementia	31.4	VEGFA PON1 APP ACE
39	pheochromocytoma	31.3	VEGFA SOD2 SOD1 HIF1A EPO EGR1
40	migraine with or without aura 1	31.3	VEGFA NOS3 ADORA3 ADORA1 ACE
41	type 2 diabetes mellitus	31.3	VEGFA TLR2 SOD2 SOD1 PRKAA2 PON1
42	macular retinal edema	31.2	VEGFA CXCL12 ACE
43	retinal artery occlusion	31.2	VEGFA HMOX1 ACE
44	hypertension, essential	31.2	VEGFA TLR2 SOD2 SOD1 PON1 NOS3
45	retinal vein occlusion	31.2	VEGFA CXCL12 ACE
46	diabetes mellitus	31.2	VEGFA TLR2 SOD2 SOD1 PRKAA2 PON1
47	pulmonary hypertension	31.2	VEGFA NOS3 HMOX1 HIF1A ACE
48	deficiency anemia	31.2	VEGFA SOD2 PON1 HMOX1 HIF1A EPO
49	eclampsia	31.1	VEGFA NOS3 ACE
50	sleep apnea	31.1	VEGFA NOS3 HIF1A EPO ACE

Graphical network of the top 20 diseases related to Ischemia:

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Symptoms & Phenotypes for Ischemia

UMLS symptoms related to Ischemia:

muscle weakness; polydipsia; angina pectoris; anoxemia

MGI Mouse Phenotypes related to Ischemia:

⁴⁵ (show all 19)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.45	ACE ADORA1 ADORA3 APP CASP3 CDK5
2	nervous system	MP:0003631	10.42	ADORA1 APP CASP3 CDK5 CXCL12 EGR1
3	cardiovascular system	MP:0005385	10.39	ACE ADORA1 ADORA3 APP CASP3 CXCL12
4	cellular	MP:0005384	10.35	ACE APP CASP3 CXCL12 EGR1 EPO
5	muscle	MP:0005369	10.34	APP CASP3 CXCL12 EPO HIF1A HMOX1
6	behavior/neurological	MP:0005386	10.34	ACE ADORA1 ADORA3 APP CASP3 CDK5
7	growth/size/body region	MP:0005378	10.32	ACE ADORA1 APP CASP3 EGR1 HIF1A
8	renal/urinary system	MP:0005367	10.31	ACE ADORA1 ADORA3 CASP3 HIF1A HMOX1
9	liver/biliary system	MP:0005370	10.29	ACE CXCL12 EGR1 EPO HIF1A HMOX1
10	immune system	MP:0005387	10.28	ACE ADORA3 APP CASP3 CXCL12 EGR1
11	endocrine/exocrine gland	MP:0005379	10.19	ACE CASP3 EGR1 HIF1A HMOX1 NOS3
12	neoplasm	MP:0002006	10.13	ACE EGR1 HIF1A SOD1 SOD2 TLR2
13	respiratory system	MP:0005388	10.11	ADORA1 ADORA3 CASP3 CDK5 EGR1 EPO
14	adipose tissue	MP:0005375	10.08	ACE HIF1A HMOX1 NOS3 PRKAA2 SOD2
15	hematopoietic system	MP:0005397	10.06	ACE ADORA1 ADORA3 APP CASP3 CXCL12
16	reproductive system	MP:0005389	10.02	ACE APP CASP3 CXCL12 EGR1 HMOX1
17	vision/eye	MP:0005391	9.96	ADORA3 APP CASP3 EGR1 HIF1A HMOX1
18	mortality/aging	MP:0010768	9.83	ACE ADORA1 APP CASP3 CDK5 CXCL12
19	integument	MP:0010771	9.36	ADORA1 ADORA3 APP CASP3 CDK5 EGR1

Sources

Drugs & Therapeutics for Ischemia

Drugs for Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 837)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tenecteplase

Approved

Phase 4

191588-94-0

Metformin

Approved

Phase 4

1115-70-4, 657-24-9

4091

Lovastatin

Approved, Investigational

Phase 4

75330-75-5

53232

Etomidate

Approved

Phase 4

33125-97-2

667484

Nadroparin

Approved, Investigational

Phase 4

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Hydromorphone

Approved, Illicit

Phase 4

466-99-9, 71-68-1

5284570

Varenicline

Approved, Investigational

Phase 4

249296-44-4

5310966

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Vecuronium

Approved, Investigational

Phase 4

50700-72-6, 86029-43-8

39765 39764

Fenofibrate

Approved

Phase 4

49562-28-9

3339

Nicardipine

Approved, Investigational

Phase 4

55985-32-5

4474

Insulin glargine

Approved

Phase 4

160337-95-1

118984454

Racivir

Approved, Investigational

Phase 4

143491-57-0, 143491-54-7

60877

Fenoldopam

Approved

Phase 4

67227-56-9, 67227-57-0

3341

Zolpidem

Approved

Phase 4

82626-48-0

5732

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

23431961

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Alprostadil

Approved, Investigational

Phase 4

745-65-3

5280723

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Dobutamine

Approved

Phase 4

34368-04-2

36811

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Amlodipine

Approved

Phase 4

88150-42-9

2162

Tamsulosin

Approved, Investigational

Phase 4

106133-20-4

129211

Nitroglycerin

Approved, Investigational

Phase 4

55-63-0

4510

Thrombin

Approved, Investigational

Phase 4

Milrinone

Approved

Phase 4

78415-72-2

4197

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Oxytocin

Approved, Vet_approved

Phase 4

50-56-6

439302 53477758

Esmolol

Approved, Withdrawn

Phase 4

103598-03-4, 81147-92-4

59768

Quinapril

Approved, Investigational

Phase 4

82586-55-8, 85441-61-8

54892

Pravastatin

Approved

Phase 4

81093-37-0

54687

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Tocopherol

Approved, Investigational

Phase 4

1406-66-2

Simvastatin

Approved

Phase 4

79902-63-9

54454

Atenolol

Approved

Phase 4

29122-68-7

2249

Vildagliptin

Approved, Investigational

Phase 4

274901-16-5

6918537

Eplerenone

Approved

Phase 4

107724-20-9

443872

Abciximab

Approved

Phase 4

143653-53-6

3815015

Streptokinase

Approved, Investigational

Phase 4

9002-01-1

Argatroban

Approved, Investigational

Phase 4

74863-84-6

152951 92722

Nitrous oxide

Approved, Vet_approved

Phase 4

10024-97-2

948

Atropine

Approved, Vet_approved

Phase 4

101-31-5, 5908-99-6, 51-55-8

3661 154417 174174

Carvedilol

Approved, Investigational

Phase 4

72956-09-3

2585

Cefuroxime

Approved

Phase 4

55268-75-2

5479529

Celecoxib

Approved, Investigational

Phase 4

169590-42-5

2662

Glyburide

Approved

Phase 4

10238-21-8

3488

Interventional clinical trials:

(show top 50) (show all 6100)

#	Name	Status	NCT ID	Phase	Drugs
1	The Potential Effect of Omega3 Supplement in Fish Oil on Infarced Areas in the Brain and Improvement of Neurological Functions fo Ischemic Stroke Patients	Unknown status	NCT04386525	Phase 4
2	One Versus Twice Daily Administration of Multiple Cardiovascular Agents in Patients With Ischemic Heart Disease: An Open Label, Randomized, Multicenter Study	Unknown status	NCT04148820	Phase 4	Aspirin, Atorvastatin, Perindopril
3	Detection of Silent Atrial Fibrillation aFter Ischemic StrOke (SAFFO) Guided by Implantable Loop Recorder. Multicentre Italian Trial Based on Stroke Unit Network With Paired Cardio-Arrhythmology Units (Italian Neurocardiology Unit Network)	Unknown status	NCT02684825	Phase 4
4	Efficacy and Safety of New Generation Drug Eluting Stents Associated With an Ultra Short Duration of Dual Antiplatelet Therapy. Design of the Short Duration of Dual antiplatElet Therapy With SyNergy II Stent in Patients Older Than 75 Years Undergoing Percutaneous Coronary Revascularization.	Unknown status	NCT02099617	Phase 4
5	A Multicenter, Double Blind, Factorial Design, Phase IV Trial to Compare the Efficacy and Safety of Cilostazol Long-term Treatment With Aspirin in Ischemic Stroke Patients With High Risk of Cerebral Hemorrhage for the Prevention of Cerebral Hemorrhage and Cardiovascular Events and to Compare the Preventive Effect of Probucol in the Same Patient Group With Non-drug User Group for the Prevention of Cardiovascular Events	Unknown status	NCT01013532	Phase 4	Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
6	Double Blind Placebo Controlled Multicenter Trial for Prevention of IMT Progression in the Ischemic Stroke Patients With High Risk of Cerebral Hemorrhage With Cilostazol and Probucol	Unknown status	NCT02483169	Phase 4	cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
7	Ischemia In Hemodialysed Patients And Outcome: Ivabradine Versus Carvedilol. A Randomized, Double Blind Study	Unknown status	NCT01425164	Phase 4	Ivabradine;Carvedilol
8	Phase IV: A Comparison of Reduced-dose Prasugrel and Clopidogrel in Elderly Patients With Acute Coronary Syndrome Undergoing Early Percutaneous Coronary Intervention (PCI)	Unknown status	NCT01777503	Phase 4	prasugrel;Clopidogrel
9	Comparison of Hyperemic Efficacy Between Nicorandil and Adenosine for Fractional Flow Reserve (FFR) Measurement	Unknown status	NCT01331902	Phase 4
10	Effect of Evolocumab in Patients With Critical Limb Ischemia	Unknown status	NCT04306471	Phase 4	Evolocumab 140mg/mL Injector 1milliliter (mL) Pen x 3 for a monthly dose of 420 mg for 12 months.
11	Efficacy of Alprostadil as an Adjuvant Therapy With Indirect Angiosomal Revascularization in Patients With Critical Limb Ischemia.	Unknown status	NCT04312555	Phase 4	Alprostadil
12	Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers	Unknown status	NCT00526695	Phase 4	Sevoflurane (Preconditioning)
13	Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study)	Unknown status	NCT02829151	Phase 4	Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
14	The EPIC (Evaluating Perioperative Ischemia Reduction by Clonidine) Study: A Randomized, Double-blinded Trial of Clonidine for Reducing Cardiac Morbidity and Mortality Following Non-cardiac Surgery.	Unknown status	NCT00335582	Phase 4	clonidine hydrochloride
15	A Randomized, Single-blind, Controlled Clinical Trial of Cardiomyopeptidin Intervention in Patients With Acute ST-segment Elevation Myocardial Infarction Undergoing Direct PCI After Ischemia-reperfusion Injury	Unknown status	NCT03958422	Phase 4	cardiomyopeptidin
16	Optimized Strategy for Diabetic Patients With Critical Limb Ischemia: A Multi-center, Randomized Controlled Trial and Registration Study(Part I)	Unknown status	NCT01171703	Phase 4
17	DCLI-II:Optimized Strategy for Diabetic Patients With Critical Limb Ischemia: A Multi-center, Randomized Controlled Trial and Registration Study(Part II)	Unknown status	NCT01173094	Phase 4
18	A Randomized Study to Evaluate Safety and Efficacy of the ExcelTM Sirolimus Eluting Stent With a Biodegradable Polymer Versus SirOlimus ELUting Stent With Non-Biodegradable Polymer in the Treatment of PatIents With de nOvo Coronary Artery LesioNs	Unknown status	NCT00825773	Phase 4
19	A Comparative Evaluation of Efficacy and Safety in the 3-Months DAPT Group vs. the 6-Months DAPT Group of Patients Treated With the Coroflex ISAR Stent; A Prospective, Multicenter, Randomized, Open-Label Clinical Trial	Unknown status	NCT02609698	Phase 4	3 months DAPT;6 months DAPT
20	Increase in Capillary Plexus Density Level Following the Use of Ozurdex for the Treatment of DME (RMSM ICOD STUDY)	Unknown status	NCT04038125	Phase 4	Ozurdex Drug Implant Product
21	Bedside Testing of the CYP2C19 Gene to Asses Effectiveness of Clopidogrel in Coronary Artery Disease Patients Treated With Percutaneous Coronary Intervention : Individualized Antiplatelet Drugs Treatment to Improve Prognosis	Unknown status	NCT01823185	Phase 4	clopidogrel;Ticagrelor or prasugrel
22	Impact of Stent Platform on Shear Stress Distribution and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES)	Unknown status	NCT01942044	Phase 4
23	Monitoring the Efficacy and Safety of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke	Unknown status	NCT01862978	Phase 4	Heparin;Nadroparin;Placebo
24	Clinical Study of Argatroban in the Treatment of Acute Progressive Ischemic Stroke	Unknown status	NCT04275180	Phase 4	Argatroban
25	Low Dose Statins, Ezetimibe and Nutraceuticals in Coronary Artery Disease Patients Intolerant to High Intensity Statin Treatment (TArget ChOlesterol)	Unknown status	NCT03277079	Phase 4	statin + ezetimibe;statin + ezetimibe + Nutraceuticals
26	The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure	Unknown status	NCT01704339	Phase 4	QUTENZA
27	The Efficacy of Lescol XL(Fluvastatin Extended Release 80 mg) on Atherosclerosis Progression in Patients With Newly Diagnosed Coronary Heart Disease	Unknown status	NCT01681199	Phase 4	Fluvastatin extended release tablet
28	Randomized Trial of the Association Between Low-Dose Statins and Nutraceuticals in High-intEnsity Statin-intoleRant patiENts With Very High Risk Coronary Artery diseasE	Unknown status	NCT02001883	Phase 4	Association low-dose statin and nutraceuticals
29	Myocardial Revascularization in Patients With Ischemic Cardiomyopathy: a Comparison Between Percutaneous Coronary Intervention and Coronary Artery Bypass Surgery	Unknown status	NCT00388245	Phase 4
30	Ranolazine Effects on Ischemic Mitral Regurgitation Severity in Patients With Cardiac Resynchronization Therapy	Unknown status	NCT01979965	Phase 4	Ranolazine (Active drug);Placebo
31	Efficacy and Safety of Xueshuanxinmaining Tablet for the Treatment of Stable Angina Pectoris: Multicenter, Randomised, Double Blind, Placebo Controlled Trial	Unknown status	NCT04270279	Phase 4	Xueshuanxinmaining tablet;Xueshuanxinmaining placebo;Nitroglycerin tablets
32	Randomized Controlled Clinical Study to Compare the Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease	Unknown status	NCT02294994	Phase 4	tirofiban
33	The Diagnostic Benefits of HyperQTM vs. Conventional ECG During Stress Test. A Comparison Study in Women Referred to Angiography.	Unknown status	NCT00850486	Phase 4
34	Study of Curative Effect Evaluation of DanLou Tablet on Coronary Artery Disease Not Amenable to Revascularization on the Basis of Western Medicine Therapy	Unknown status	NCT03072082	Phase 4	Danlou Tablet;DanLou Tablet placebo;Aspirin Enteric-coated Tablets;Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet;Atorvastatin calcium;Isosorbide Mononitrate Tab 20 MG;Metoprolol Tartrate Tab 25 MG;Trimetazidine Dihydrochloride Tablets
35	The Efficacy and Safety of Paclitaxel-eluting SeQuent Please Drug-Eluting Balloon for Treatment of lesiOns in Native smalL coronarY Arteries (DEB-ONLY)	Unknown status	NCT01903902	Phase 4
36	A Randomized, Double-blind, Multi-centered, Placebo-controlled Trial to Examine Effects of Heart-protecting Musk Pill on Clinical Outcome in Patients With Chronic Stable Coronary Artery Disease	Unknown status	NCT01897805	Phase 4	Heart-protecting Musk Pill;Placebo
37	A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer Sirolimus-eluting Stent Safety and Effectiveness in Treatment of Coronary Artery Disease	Unknown status	NCT01880879	Phase 4
38	Cardiac Metabolic Modulator Treatment for Improvement of Left Ventricular Diastolic Function in Patients With Coronary Heart Disease: a Prospective, Randomized Controlled Study	Unknown status	NCT03887013	Phase 4	Trimetazidine
39	The Differentiation and Treatment Scheme of TCM Key Syndromes for the Treatment of Acute Disabling Ischemic Stroke: a Randomized, Double-Blind, Placebo-Controlled Multicenter Trial	Unknown status	NCT04199455	Phase 4	Integrative Treatment (EPACH Recipe Granules + NQABC Recipe Granules);Placebo
40	The Protective Effect of the α2-agonist Dexmedetomidine on Mitochondrial Structure and Function for Children With Non-cyanotic Congenital Heart Defects Having Cardiac Surgery: A Randomized Controlled Trial.	Unknown status	NCT02299063	Phase 4	Dexmedetomidine;0.9% NaCl
41	Xingnaojing for Moderate-to-severe Acute Ischemic Stroke (XMAS): A Multicenter, Prospective, Randomized, Open-label, Blinded Endpoint Clinical Trial.	Unknown status	NCT02728180	Phase 4	Xingnaojing injection
42	Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study (AFIRE Study)	Unknown status	NCT02642419	Phase 4	Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
43	The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial	Unknown status	NCT00724724	Phase 4	Butylphthalide Soft Capsules;Aspirin
44	A Multicenter, Open Labeled, Cross-Over Designed Prospective Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis	Unknown status	NCT00433823	Phase 4	Atorvastatin, Ezetimibe
45	Cholesterol Reduction With Evolocumab and Coronary MicrovascuLar Function and Coronary Flow: The CHORAL Flow Study	Unknown status	NCT04073134	Phase 4	Placebo
46	Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study	Unknown status	NCT03700645	Phase 4	Allopurinol
47	The Efficacy of Glycemic Control With Continuous Glucose Monitoring on Atheroma Progression: Rationale and Design of the Observation of Coronary Atheroma Progression Under Continuous Glucose Monitoring Guidance in Patients With Type 2 Diabetes Mellitus	Unknown status	NCT04559191	Phase 4
48	Studies of Application of Combined General Anesthesia and Bilateral Thoracic Paravertebral Block by Ropivacaine in Patients Undergoing Off-pump Coronary Artery Bridge Graft - a Random Double Blind Controlled Study	Unknown status	NCT02727712	Phase 4	Anesthesia drugs during the surgery
49	Multicenter Trial on Clinical Utility of Acarbose in Patients With Ischemic Heart Disease Accompanied by Abnormal Glucose Regulation	Unknown status	NCT00858676	Phase 4	acarbose
50	Overcoming High On-Treatment Platelet Reactivity (HPR) During Prasugrel Therapy	Unknown status	NCT01869309	Phase 4	Prasugrel;Ticagrelor

Search NIH Clinical Center for Ischemia

Cochrane evidence based reviews: ischemia

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Genetic Tests for Ischemia

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Anatomical Context for Ischemia

Organs/tissues related to Ischemia:

MalaCards : Bone Marrow, Heart, Brain, Endothelial, Liver, Bone, Spinal Cord

Sources

Publications for Ischemia

Articles related to Ischemia:

(show top 50) (show all 31421)

#	Title	Authors	PMID	Year
1	Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. ⁵³ ⁶²	Xu L...Giffard RG	20235222	2010
2	Ischemia induces endoplasmic reticulum stress and cell apoptosis in human brain. ⁵³ ⁶²	Duan SR...Wang DS	20347937	2010
3	Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease. ⁵³ ⁶²	Juncos JP...Nath KA	20107113	2010
4	Low-dose cardiotonic steroids increase sodium-potassium ATPase activity that protects hippocampal slice cultures from experimental ischemia. ⁵³ ⁶²	Oselkin M...Bergold PJ	19822191	2010
5	Vascular responses to hypoxia and ischemia. ⁵³ ⁶²	Semenza GL	19729615	2010
6	Effects of AMP-activated protein kinase in cerebral ischemia. ⁵³ ⁶²	Li J...McCullough LD	20010958	2010
7	Protective effect of albumin on VEGF and brain edema in acute ischemia in rats. ⁵³ ⁶²	Yao X...Feng H	20138968	2010
8	The possible mechanism for impaired angiogenesis after transient focal ischemia in type 2 diabetic GK rats: different expressions of angiostatin and vascular endothelial growth factor. ⁵³ ⁶²	Zhu M...Shangguan S	19932587	2010
9	B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary-Thrombolysis In Myocardial Infarction 36) trial. ⁵³ ⁶²	Morrow DA...Braunwald E	20298924	2010
10	Angiogenic effects of stromal cell-derived factor-1 (SDF-1/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia. ⁵³ ⁶²	Ho TK...Baker DM	20206813	2010
11	Loss of clusterin expression worsens renal ischemia-reperfusion injury. ⁵³ ⁶²	Zhou W...Du C	20007348	2010
12	Heme oxygenase-1 protects donor livers from ischemia/reperfusion injury: the role of Kupffer cells. ⁵³ ⁶²	Zeng Z...Zhang YJ	20222175	2010
13	Selective intrarenal human A1 adenosine receptor overexpression reduces acute liver and kidney injury after hepatic ischemia reperfusion in mice. ⁵³ ⁶²	Park SW...Lee HT	20065944	2010
14	A highlight of myoglobin diversity: the nitrite reductase activity during myocardial ischemia-reperfusion. ⁵³ ⁶²	Hendgen-Cotta UB...Rassaf T	19836457	2010
15	Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. ⁵³ ⁶²	Stetler RA...Chen J	20133634	2010
16	Cardiac protection by basic fibroblast growth factor from ischemia/reperfusion-induced injury in diabetic rats. ⁵³ ⁶²	Xiao J...Tan Y	20190407	2010
17	Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion. ⁵³ ⁶²	Qi D...Young LH	19920350	2009
18	Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. ⁵³ ⁶²	Qian J...Kranias EG	19850943	2009
19	Allopurinol, xanthine oxidase, and cardiac ischemia. ⁵³ ⁶²	Lee BE...Toledo-Pereyra LH	19794315	2009
20	Association of cystatin C with ischemia in patients with coronary heart disease. ⁵³ ⁶²	Deo R...Whooley MA	19816865	2009
21	Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes. ⁵³ ⁶²	Seo JY...Won MH	19576596	2009
22	Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia. ⁵³ ⁶²	Greco S...Martelli F	19528256	2009
23	Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2. ⁵³ ⁶²	Produit-Zengaffinen N...Schorderet DF	19862336	2009
24	Involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by post-conditioning. ⁵³ ⁶²	Fernandez DC...Rosenstein RE	19682205	2009
25	Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response. ⁵³ ⁶²	Doroudgar S...Glembotski CC	19622751	2009
26	Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides. ⁵³ ⁶²	Tokudome T...Kangawa K	19628785	2009
27	Enterocyte shedding and epithelial lining repair following ischemia of the human small intestine attenuate inflammation. ⁵³ ⁶²	Matthijsen RA...Buurman WA	19753114	2009
28	Hypothermia attenuates ischemia/reperfusion-induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling. ⁵³ ⁶²	Yang D...Li H	19596001	2009
29	Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion. ⁵³ ⁶²	Wang M...Meldrum DR	19628067	2009
30	Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase. ⁵³ ⁶²	Izumi Y...Iwao H	19498441	2009
31	The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. ⁵³ ⁶²	Kato N...Kadomatsu K	19443639	2009
32	Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine. ⁵³ ⁶²	Urmaliya VB...White PJ	19333129	2009
33	The neuronal apoptotic death in global cerebral ischemia in gerbil: important role for sodium channel modulator. ⁵³ ⁶²	Brahma MK...Ray M	19115407	2009
34	Effects of overexpression of antioxidants on the release of cytochrome c and apoptosis-inducing factor in the model of ischemia. ⁵³ ⁶²	Zemlyak I...Sapolsky RM	19429031	2009
35	Angiopoietin-1 in the treatment of ischemia and sepsis. ⁵³ ⁶²	Novotny NM...Meldrum DR	18791498	2009
36	Effects of PACAP and preconditioning against ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro. ⁵³ ⁶²	Roth E...Racz B	19456402	2009
37	Circulating biochemical markers of brain damage in infants complicated by ischemia reperfusion injury. ⁵³ ⁶²	Gazzolo D...Florio P	19355873	2009
38	Ischemia detected on continuous electrocardiography after acute coronary syndrome: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis In Myocardial Infarction 36) trial. ⁵³ ⁶²	Scirica BM...Braunwald E	19371824	2009
39	Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia. ⁵³ ⁶²	Toyama K...Kocsis JD	19094989	2009
40	Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats. ⁵³ ⁶²	Matayoshi H...Sakabe T	19168036	2009
41	Transient postprandial ischemia is associated with increased intestinal fatty acid binding protein in patients with chronic gastrointestinal ischemia. ⁵³ ⁶²	Mensink PB...Kolkman JJ	19279473	2009
42	Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment. ⁵³ ⁶²	Guo S...Shi H	19183269	2009
43	Expression of tissue-type transglutaminase (tTG) and the effect of tTG inhibitor on the hippocampal CA1 region after transient ischemia in gerbils. ⁵³ ⁶²	Hwang IK...Seong JK	19368835	2009
44	Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin. ⁵³ ⁶²	Bailey AM...Peirce SM	19247427	2009
45	Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury. ⁵³ ⁶²	Scarabelli TM...Suzuki H	19116149	2009
46	FAK regulates cardiomyocyte survival following ischemia/reperfusion. ⁵³ ⁶²	Hakim ZS...Taylor JM	19028502	2009
47	Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. ⁵³ ⁶²	Gilbert JS...Granger JP	19075097	2009
48	Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. ⁵³ ⁶²	Xie P...Li H	19117950	2009
49	Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. ⁵³ ⁶²	Eltzschig HK...Colgan SP	18812468	2009
50	Regulation of cardiac afferent excitability in ischemia. ⁵³ ⁶²	Fu LW...Longhurst JC	19655108	2009

Sources

Genes for Ischemia

Genes related to Ischemia (0 elite genes):

(show top 50) (show all 87)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	LINC01254	Long Intergenic Non-Protein Coding RNA 1254	RNA Gene	150	Experimental evidence: Expression ³⁷	29434722
2	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	34.87	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	10696063 11414092 17823371 (more) 11943724 15809599 7525111 9275547 16469952 12566361 17095533 9620141 11279416 15880052 7943370 12415365 17072059 18243616 17363691 16642030 11208453 8942877 16198014 20138968 15073528 10864908 9386128 15188944 9626071 12642354 15920995 9422853 9890208 10329259 16146767 17234965 17610292 12359828 11591302 11547309 11176533 10424577 9638422 9008628 8874381 8756616 14638927 12866606 12545262 12152001 11150374 10742156 10634417 10688416 19199967 15652951 15077930 14999223 12560698 12383357 11783349 11325212 9560833 9537336 11405837 11319619 10643294 9648990 19967679 19624285 16639424 17157396 16963303 16273763 15768015 9046048 8989142 18504100 18260956 16921341 16641198 16138473 15840902 18593442 17308528 15631337 14630296 14526434 12592265 12582471 11029398 19269219 19340019 15616645 7586439 7565686 7531786 7922097 19199897 17140946
3	ADORA3	Adenosine A3 Receptor	Protein Coding	30.63	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	9988118 12970092 10355598 (more) 15922260 11488425
4	SOD2	Superoxide Dismutase 2	Protein Coding	28.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	7798339 9081096 11672836 (more) 9925365 1337859 14681883 10821417 8576926 11440438 11225732 12160946 12364860 20235222 8238402 11328670 7751851 19293328 11450026 19917352 2397290
5	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	28.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Proteins (show sections)	17363691 18596986 16439688 (more) 17474298 18709383 19595531 16380482 20196780 20206813 16168287 17145991 20132055
6	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	26.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	15507450 12392881 18719595 (more) 17332438 17597581 12065600 16497986 16844922 20010958 14594564 19498441 17337600 19911004 12689619 19920350 12392882 14684182
7	ACE	Angiotensin I Converting Enzyme	Protein Coding	26.53	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
8	SLC8A2	Solute Carrier Family 8 Member A2	Protein Coding	26.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	15472108
9	EGR1	Early Growth Response 1	Protein Coding	25.45	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Functions (show sections)	14715474 9302090 15507240 (more) 8408317 8964794 10479642
10	PON1	Paraoxonase 1	Protein Coding	25.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	18976644 19842447
11	EPO	Erythropoietin	Protein Coding	25.1	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
12	CDK5	Cyclin Dependent Kinase 5	Protein Coding	24.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Proteins (show sections)	19812325 17113760 16815303 (more) 16958987 16166266 15689152
13	CASP3	Caspase 3	Protein Coding	24.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16439666 15498374 10793243 (more) 9406913 11120068 12812761 15184368 19154929 9530276 11207385 15305862 10200473 16864802 15793278 15028768 12954454 17138646 17071204 15836924 15496305 15201704 19716047 17463315 16009702 12605885 10995832 12865128 10397630 16876202 20152804 16874559 17172266 17514421
14	HMOX1	Heme Oxygenase 1	Protein Coding	24.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17522519 16775600 15996234 (more) 20222175 18262556 10566971 19384082 12352873 10985695 12180835 15084179 14525760 15908766 12177608 16738898 15925276 15478901 10655265 20304018 19036700 16847723 19362144 18776993 18576916 20107113 19075097 11930234 19293937 16902317 12394829 18286266 18538757 17845132 14638927 19885035 17920074 16276211 10817588 15531134 15599312
15	NOS3	Nitric Oxide Synthase 3	Protein Coding	24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19340549 15091107 15327760 (more) 11485370 14560236 11708836 11255630 15710249 17904064 9428309 10758392 11861037 17230207 15809599 12788059 20107113 17386181 20154403 18595762 17357484 12897144 9616228 17855002 16689381 11694897 17409706 15198930 15922259 11215533
16	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	23.77	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16423235 17511040 16278378 (more) 12605132 15921668 15316398 18371939 10486175 18728783 17932327 16208522 19766670 16417583 17519789 10699162 18842422 18450499 10696063 19602906 19015446 17656571 19804771 16204254 18790175 18559422 20443865 18287515 16414399 14962475 15135259
17	TLR2	Toll Like Receptor 2	Protein Coding	23.73	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Drugs & Compounds (show sections)
18	APP	Amyloid Beta Precursor Protein	Protein Coding	23.73	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
19	SOD1	Superoxide Dismutase 1	Protein Coding	23.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16678801 8369736 9232283 (more) 7798339 9270054 8369963 7835751 12215379 2232247 8092297 2155521 2199842 11705765 1585847 8950309 11473663 9510075 2130596 1333498 17229981 16889680 15993338 15862706 11783328 1645750 2028497 2306117 17320858 15477017 15350647 14706203 9011676 8848412 11672836 11374814 9774189 9539776 9515237 1731423 1651115 2067022 1709221 11478786 9880490 9393864 2341056 11033410 19087872 16308941 2200914 20521981 19482302 17963638 11488406 8902543 7858957 7910380 8073465 8023358 8255372 8478571 2067024 17203243 15518711 14650208 8065523 8276180 1528101 1928219 1317470 1413627 1335039
20	ADORA1	Adenosine A1 Receptor	Protein Coding	22.85	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7884404 10396621 11744026 (more) 18535281 20065944 8650986 8805806 9769229 10870516 9261897 10839921 8339412 18950269 12486190 1613814 19333129
21	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	22.74	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10227621 15356416 12163437 (more) 10735421 1910211 1902405 8101512 10745480 16102101 15579144 12086588 8712112 8803721 10684070 15088184 16228804 17656661 19781532 17262195 9120173 15846799 15380485 11208259 10390117 9741502 7876657 8402758 20422794 16497981 15286558 10917348 12228252 19513336 18208365 16209928 15516929 11019996 10080463 7594098 11263625
22	EDN1	Endothelin 1	Protein Coding	22.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16741002 11399337 8547550 (more) 15378116 8561606 11311331 7586445 10446311 9254095 9539486 8840871 17196275 7472751 7583211 10569670 10711778 10462014 12529269 11904533 12375155 11389424 9780700 9104911 7815811 17603693 17229981 15815585 14714357 10912471 9344560 8033346 12667626 9201047 14640891 11563817 9746797 19114919 17656571 17239538 10371763 8742913 7874342 18388063 16814412 15862786 8739884 15477464 16820593 18981324 19704104 8143509 7937321
23	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	22.58	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
24	NOS2	Nitric Oxide Synthase 2	Protein Coding	22.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15327760 16154689 11708836 (more) 8787213 11255630 9100245 17509226 18024942 9514534 9770692 10534001 11890738 12800488 15761336 19212422 15853684 17689088 11119875 10320673 10320661 17337232 17308528 16974762 16495814 11861037 9875644 11139361 10860773 9561126 16474186 9150442 8896427 19482302 14527083 10781440 20107113 19519641 18790185 17386181 16474996 15993340 15625011 9843159 19293937 18595762 16765486 9833145 7543258 7689711 17339545 16837917 14587881 12478411 11901182 17562036 15331549 17172266 16035616 12702642 10611056 11215533
25	MB	Myoglobin	Protein Coding	22.51	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15956741 19046720 9033286 (more) 12580453 16888448 1712406 8664019 9771572 16035692 17568573 17505311 1871123 11567670 11326340 19836457 15540688 18200568 8653228 11373981 11564382 17186297 18261919 18971915 19277696
26	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	22.46	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
27	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	22.43	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8249024 8364736 8239864 (more) 7982052 8361666 8361650 8360284 8515271 8548318 1908957 7689912 1291030 8431764 7854054 8332741 2027539 1636489 8090362 8255174 2122554 12841628 9930891 8930384 12585105 16720354 12687618 10908035 7706492 2016350 2275846 16048836 11044589 9200755 8474691 10668996 7671259 8515688 12921616 15961120 2097376 15996234 9120008 8271311 8221063 9302090 17211353 8326014
28	MPO	Myeloperoxidase	Protein Coding	22.43	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18601914 8116953 11296329 (more) 8606272 1337651 9141430 11834354 9701345 16112968 1653385 19087872 15718920 16545368 12813366 11897624 10608592 8026207 8222181 19626395 15175825 12480701 17981193 10369086 12177608 9185246 19011099 11787641 7998704
29	PRKCE	Protein Kinase C Epsilon	Protein Coding	22.35	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
30	KNG1	Kininogen 1	Protein Coding	22.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10483942 1452374 7934098 (more) 17022964 9293965 10395480 11023968 9477040 11741551 18344203 1588616 14991335 8586324 17897043 15922253 11289084 15962100 10415540 19655108 18375591 12800488 17516166
31	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	22.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Proteins (show sections)	15836924
32	CYCS	Cytochrome C, Somatic	Protein Coding	22.16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9886353 10793243 19944742 (more) 10643799 10592304 15789032 10553953 12689815 2168094 11850108 15184368 16513219 20449909 9714744 15037208 16093501 16828795 11452765 19429031 15172883 12605885 8834222 15004034 16971498 12388298 15120593 19299628 14519437 14650208 19115407 9162279
33	XDH	Xanthine Dehydrogenase	Protein Coding	22.09	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8357220 2008472 7978659 (more) 7716606 2374259 1720611 18074171 10797836 11200091 15147422 1689383 19794315 8428505 8121173 7884404 8855487 1568395 8284091 8874300 14706203 9299379 9299367 8902306 7986063 8176964 1650213 2303992 10734080 8513435 1653385 2253787 11998976 9554965 7989578 8397177 1793873 1695516 11905046 9515237 8412098 2170383 15621709 9295833 8221022 2225227 12168784 10436441 12388055 19539448 8298062
34	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	21.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18929647 11919512 10190144 (more) 9591846 16710998 19235887 20036928 10082831 19355873 19899109 16245211 16464366 19278884 16866629 8915593 8422577 19682205 15328028 8277338 10415428 12776558 1350252 8737665
35	SELP	Selectin P	Protein Coding	21.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19917355 9852932 12844097 (more) 17650080 9814634 10342318 12433835 14702531 15844702 17627509 17275499 12829075 7505494 11586150 14609594 16134601 19247427
36	REST	RE1 Silencing Transcription Factor	Protein Coding	21.58	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Functions (show sections)
37	MAP2	Microtubule Associated Protein 2	Protein Coding	21.43	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8051544 8898691 9069442 (more) 7672005 7970228 7712174 8186966 16250084 16328528 8937017 2243357 15498374 15556012 7838065 8386729 9776521 9443659 8530550 8982684
38	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	21.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7604425 8276180 8025704 (more) 9566609 2050750 9535112 7772873 9804366 20235222 16100242 10999652 8847992 15241191 12595341 10978340 11078935 9666068 10481875 10571093
39	CTSL	Cathepsin L	Protein Coding	21.3	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
40	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	21.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19917355 9184651 19649220 (more) 9583490 10066673 9416264 9688666 14705823 9186042 9754602 12497551 17511040 9690227 9603092 8843727 9211017 10066862 11450070 10580798 1352679 10096530 15837532
41	FGF2	Fibroblast Growth Factor 2	Protein Coding	21.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9054845 8892777 17064673 (more) 8575238 11423931 17177736 18758090 7586439 11953278 12414042 12730553 12467820 11319619 9422853 9890208 10521571 16846360 9120166 14630296 8481788 20190407 17652878 15171620 14583313 20136400 17687397 14981457 14656920 18573330 17494864 8651097 8281447 16518534 16146647 10752546 12623787 12566361 9151769 19544425 17157396 17087309 16283765 14526434 11958389 17693930 18728783 8117201 11028477 11304894
42	DAPK1	Death Associated Protein Kinase 1	Protein Coding	21.02	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Functions (show sections)
43	NPPB	Natriuretic Peptide B	Protein Coding	20.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16209968 14662720 15542281 (more) 17218198 19685518 15019872 18951935 15374788 16762755 15542280 17067699 12020494 17442418 16781223 16112956 20298924 18632168 14693575 17039908 17516166 12709407 18824903 19752486 19628785 14577006 8636398 17626979 16092582 16468422 16253599 14564226 12801444 15026268 8631038 19642911 14574059 12621153 18366308 15948103 18620103 19121444 19275472
44	NOS1	Nitric Oxide Synthase 1	Protein Coding	20.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9950505 15327760 9770692 (more) 11255630 16084499 10083068 10927171 11087833 18309922 9843159 7535657 10401604 18234158 9989455 9593932 7508155 18512761 8710192
45	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	20.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8763397 7579841 11407735 (more) 18708091 11895467 12826510 18316485 8251420 9515018 8294705 8030893
46	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	20.71	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10366190 17122424 15468177 (more) 16830212 11343855 12742081 18326497 9307255
47	MCU	Mitochondrial Calcium Uniporter	Protein Coding	20.51	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Functions (show sections)
48	KCNB1	Potassium Voltage-Gated Channel Subfamily B Member 1	Protein Coding	20.43	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins (show sections)
49	KDR	Kinase Insert Domain Receptor	Protein Coding	20.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11943724 18451337 11967019 (more) 18406051 16680073
50	MIR21	MicroRNA 21	RNA Gene	20.17	DISEASES inferred ¹⁴ ¹⁴ GeneCards inferred via : Publications (show sections)

Sources

Variations for Ischemia

Copy number variations for Ischemia from CNVD:

⁶

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	72977	12	89000000	92600000	Copy number	GALNT4	Acute coronary syndrome

Sources

Expression for Ischemia

Search GEO for disease gene expression data for Ischemia.

Sources

Pathways for Ischemia

Pathways related to Ischemia according to GeneCards Suite gene sharing:

(show all 25)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.87	VEGFA TLR2 SOD2 SOD1 NOS3 HMOX1
2	Signal Transduction ⁶⁶	13.15	VEGFA PRKAA2 NOS3 HIF1A EPO EGR1
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.94	APP CASP3 EGR1 HIF1A HMOX1 SOD1
4	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.76	EPO HIF1A NOS3 PRKAA2 TLR2 VEGFA
5	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.67	NOS3 EPO EGR1 CXCL12 ADORA3
6	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.56	VEGFA NOS3 HIF1A EGR1 CXCL12 CDK5
7	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	12.34	NOS3 EGR1 CDK5 CASP3
8	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12	VEGFA HIF1A EGR1 CASP3
9	Allograft rejection ⁷⁴	11.76	VEGFA CXCL12 CASP3
10	Corticotropin-releasing hormone signaling pathway ⁷⁴	11.75	PRKAA2 NOS3 CASP3
11	Angiogenesis (CST) ³	11.72	NOS3 HMOX1 HIF1A
12	Burn wound healing ⁷⁴	11.63	CASP3 CXCL12 VEGFA
13	Defective Intrinsic Pathway for Apoptosis ⁶⁶ Show member pathways Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models ⁶⁶ Neurodegenerative Diseases ⁶⁶	11.57	SOD2 CDK5 APP
14	Copper homeostasis ⁷⁴ Show member pathways Copper metabolism ⁷⁴ Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) ⁶⁶	11.49	SOD1 CASP3 APP
15	Neurogenesis regulation in the olfactory epithelium ⁷⁴	11.47	CXCL12 CDK5 APP
16	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.44	VEGFA HIF1A CASP3
17	Photodynamic therapy-induced HIF-1 survival signaling ⁷⁴	11.2	VEGFA HIF1A EPO
18	HIF1Alpha Pathway ⁶⁴	11.19	VEGFA NOS3 HIF1A EPO
19	Oxidative stress response ⁷⁴	11.13	SOD2 SOD1 HMOX1
20	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	11.06	VEGFA HIF1A EGR1
21	VEGFR1 specific signals ⁶¹	10.9	VEGFA NOS3 HIF1A
22	HIF-1-alpha transcription factor network ⁶¹	10.83	VEGFA HMOX1 HIF1A EPO CXCL12
23	Aspirin and miRNAs ⁷⁴	10.59	VEGFA NOS3
24	Arsenic metabolism and reactive oxygen species generation ⁷⁴	10.58	SOD2 SOD1
25	MicroRNA for targeting cancer growth and vascularization in glioblastoma ⁷⁴ Show member pathways Oncostatin M signaling pathway ⁷⁴	10.52	VEGFA HIF1A

Sources

GO Terms for Ischemia

Cellular components related to Ischemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:0043025	9.4	SOD1 SLC8A2 PRKAA2 CDK5 CASP3 ADORA1

Biological processes related to Ischemia according to GeneCards Suite gene sharing:

(show all 42)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.44	VEGFA TLR2 NOS3 HIF1A EGR1 APP
2	negative regulation of gene expression	GO:0010629	10.35	VEGFA PRKAA2 HIF1A APP ACE
3	response to xenobiotic stimulus	GO:0009410	10.3	SOD2 SOD1 HMOX1 CASP3 ACE
4	positive regulation of angiogenesis	GO:0045766	10.29	VEGFA NOS3 HMOX1 HIF1A
5	aging	GO:0007568	10.28	SOD2 SOD1 EPO ACE
6	negative regulation of cell population proliferation	GO:0008285	10.25	TLR2 SOD2 NOS3 HMOX1 APP ADORA3
7	apoptotic process	GO:0006915	10.2	TLR2 SOD1 HMOX1 HIF1A EPO CDK5
8	negative regulation of neuron apoptotic process	GO:0043524	10.19	HIF1A HMOX1 SOD1 SOD2
9	response to heat	GO:0009408	10.16	SOD1 NOS3 CXCL12
10	cognition	GO:0050890	10.15	SLC8A2 APP ADORA1
11	visual learning	GO:0008542	10.14	HIF1A CDK5 APP
12	positive regulation of blood vessel endothelial cell migration	GO:0043536	10.11	VEGFA NOS3 HIF1A
13	neuron apoptotic process	GO:0051402	10.11	HIF1A CDK5 CASP3 APP
14	response to oxidative stress	GO:0006979	10.09	SOD2 SOD1 HMOX1 APP
15	response to axon injury	GO:0048678	10.07	SOD2 SOD1 EPO
16	negative regulation of apoptotic process	GO:0043066	10.06	VEGFA SOD2 SOD1 PRKAA2 HIF1A EPO
17	positive regulation of macroautophagy	GO:0016239	10.03	HIF1A HMOX1 PRKAA2
18	response to nutrient levels	GO:0031667	10.02	ACE PON1 SOD1 SOD2
19	positive regulation of neuron death	GO:1901216	10	EGR1 CDK5 ADORA1
20	positive regulation of glycolytic process	GO:0045821	10	PRKAA2 HIF1A APP
21	relaxation of vascular associated smooth muscle	GO:0060087	9.99	SOD1 ADORA1
22	cellular oxygen homeostasis	GO:0032364	9.97	HIF1A SOD2
23	positive regulation of axon extension involved in axon guidance	GO:0048842	9.97	CXCL12 VEGFA
24	response to hydrogen peroxide	GO:0042542	9.97	CASP3 HMOX1 SOD1 SOD2
25	modulation of excitatory postsynaptic potential	GO:0098815	9.96	SLC8A2 APP
26	regulation of blood pressure	GO:0008217	9.96	SOD2 SOD1 NOS3 HMOX1 ACE
27	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO:0043619	9.95	HMOX1 HIF1A
28	hemoglobin biosynthetic process	GO:0042541	9.94	HIF1A EPO
29	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.93	VEGFA HIF1A
30	negative regulation of renal sodium excretion	GO:0035814	9.93	ADORA1 ACE
31	response to superoxide	GO:0000303	9.92	SOD2 SOD1
32	vasodilation	GO:0042311	9.91	ADORA1 NOS3 SOD2
33	response to lipopolysaccharide	GO:0032496	9.9	ACE CASP3 EPO NOS3 SOD2 TLR2
34	positive regulation of hormone biosynthetic process	GO:0046886	9.88	HIF1A EGR1
35	microglia development	GO:0014005	9.88	TLR2 APP
36	removal of superoxide radicals	GO:0019430	9.88	SOD2 SOD1 NOS3
37	response to radiation	GO:0009314	9.87	APP CXCL12 SOD2
38	positive regulation of peptidyl-tyrosine autophosphorylation	GO:1900086	9.85	VEGFA ACE
39	smooth muscle hyperplasia	GO:0014806	9.84	NOS3 HMOX1
40	response to reactive oxygen species	GO:0000302	9.8	SOD2 SOD1 HIF1A
41	positive regulation of chemokine production	GO:0032722	9.65	TLR2 HMOX1 HIF1A EGR1 APP
42	response to hypoxia	GO:0001666	9.64	VEGFA TLR2 SOD2 HMOX1 HIF1A EPO