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MCID: ISC005
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Ischemic Bone Disease

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Ischemic Bone Disease

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MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease 12 15

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0080008
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Summaries for Ischemic Bone Disease

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Disease Ontology : 12 A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondrosis and osteonecrosis. An important gene associated with Ischemic Bone Disease is TBXAS1 (Thromboxane A Synthase 1), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Affiliated tissues include bone, bone marrow and kidney, and related phenotypes are craniofacial and immune system

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Related Diseases for Ischemic Bone Disease

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Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 osteochondrosis 31.5 COL2A1 KLHDC2 TBXAS1
2 osteonecrosis 30.7 ACP5 BGLAP BMP2 COL2A1 FDPS PTH
3 bone disease 28.7 ACAN ACP5 BGLAP COL2A1 PTH RUNX2
4 osteochondritis dissecans 11.0
5 dysbaric osteonecrosis 11.0
6 bone fracture 10.3 BGLAP BMP2
7 tooth ankylosis 10.3 BMP2 TNFSF11
8 pseudoarthrosis 10.2 BMP2 PTH
9 axial osteomalacia 10.2 BGLAP PTH
10 extraskeletal chondroma 10.2 BGLAP PTH
11 villonodular synovitis 10.2 ACP5 TNFSF11
12 multicentric reticulohistiocytosis 10.2 TNFRSF11B TNFSF11
13 periodontitis, chronic 10.2 TNFRSF11B TNFSF11
14 bone chondrosarcoma 10.2 ACAN RUNX2
15 breast leiomyosarcoma 10.2 TNFRSF11A TNFSF11
16 chronic apical periodontitis 10.2 TNFRSF11B TNFSF11
17 fibrogenesis imperfecta ossium 10.2 PTH TNFRSF11B
18 osteopetrosis, autosomal recessive 7 10.2 TNFRSF11A TNFSF11
19 ossification of the posterior longitudinal ligament of spine 10.2 BGLAP BMP2 RUNX2
20 tympanosclerosis 10.2 BMP2 COL2A1
21 osseous heteroplasia, progressive 10.2 BGLAP BMP2 RUNX2
22 synovial chondromatosis 10.2 BMP2 COL2A1 RUNX2
23 osteomyelitis 10.2 ACP5 BMP2 TNFSF11
24 endosteal hyperostosis, autosomal dominant 10.2 BMP2 TNFRSF11B TNFSF11
25 alveolar periostitis 10.2 BGLAP RUNX2
26 achondrogenesis, type ia 10.2 ACAN COL2A1
27 critical limb ischemia 10.2 TNFRSF11B VEGFA
28 arthropathy 10.2 ACAN TNFRSF11B TNFSF11
29 bone deterioration disease 10.2 ACAN BMP2 COL2A1
30 bone structure disease 10.2 ACAN BMP2 COL2A1
31 vitreoretinal dystrophy 10.2 BGLAP COL2A1
32 polyarticular onset juvenile idiopathic arthritis 10.2 TNFRSF11A TNFRSF11B TNFSF11
33 hemophilic arthropathy 10.2 TNFRSF11A TNFRSF11B TNFSF11
34 paget disease of bone 5, juvenile-onset 10.2 TNFRSF11A TNFRSF11B TNFSF11
35 familial expansile osteolysis 10.2 TNFRSF11A TNFRSF11B TNFSF11
36 eye degenerative disease 10.1 COL2A1 VEGFA
37 kummell's disease 10.1 SOST TNFRSF11B TNFSF11
38 differentiated thyroid carcinoma 10.1 BGLAP TNFRSF11B VEGFA
39 periodontitis 10.1 BGLAP RUNX2 TNFRSF11B TNFSF11
40 osteitis fibrosa 10.1 BGLAP PTH
41 aortic valve disease 2 10.1 BMP2 RUNX2 TNFRSF11B TNFSF11
42 impaired renal function disease 10.1 BGLAP PTH SOST
43 sclerosteosis 1 10.1 SOST SP7
44 osteoporosis, juvenile 10.1 BGLAP PTH SOST
45 osteochondrodysplasia 10.1 BGLAP COL2A1 SP7
46 pfeiffer syndrome 10.1 BGLAP RUNX2 SP7
47 hypercementosis 10.1 ACP5 SOST TNFRSF11A
48 multicentric carpotarsal osteolysis syndrome 10.1 BGLAP TNFRSF11A TNFRSF11B TNFSF11
49 aortic valve disease 1 10.1 ACAN BMP2 RUNX2 TNFRSF11B
50 periodontal disease 10.1 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Ischemic Bone Disease:



Diseases related to Ischemic Bone Disease
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Symptoms & Phenotypes for Ischemic Bone Disease

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MGI Mouse Phenotypes related to Ischemic Bone Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.91 BMP2 COL2A1 KLHDC2 PTH RUNX2 TNFRSF11A
2 immune system MP:0005387 9.85 BMP2 COL2A1 KLHDC2 PTH RUNX2 TBXAS1
3 limbs/digits/tail MP:0005371 9.65 BMP2 COL2A1 PTH RUNX2 SOST SP7
4 skeleton MP:0005390 9.32 BMP2 COL2A1 PTH RUNX2 SOST SP7
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Drugs & Therapeutics for Ischemic Bone Disease

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Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

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Genetic Tests for Ischemic Bone Disease

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Anatomical Context for Ischemic Bone Disease

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MalaCards organs/tissues related to Ischemic Bone Disease:

41
Bone, Bone Marrow, Kidney, Eye, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

19
Bone
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Publications for Ischemic Bone Disease

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Articles related to Ischemic Bone Disease:

# Title Authors Year
1
Bone marrow edema: mild or nascent variant of ischemic bone disease. ( 18083442 )
2008
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Variations for Ischemic Bone Disease

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Expression for Ischemic Bone Disease

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Search GEO for disease gene expression data for Ischemic Bone Disease.
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Pathways for Ischemic Bone Disease

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Pathways related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
RANK Signaling in Osteoclasts 64
Show member pathways
 12.16 ACP5 TNFRSF11A TNFRSF11B TNFSF11
2
Osteoclast differentiation 37
11.84 ACP5 TNFRSF11A TNFRSF11B TNFSF11
3
Parathyroid hormone synthesis, secretion and action 37
11.74 BGLAP PTH RUNX2 SOST TNFSF11
4
Rheumatoid arthritis 37
11.66 ACP5 TNFRSF11A TNFSF11 VEGFA
5
Endochondral Ossification 1
11.47 ACAN COL2A1 PTH RUNX2 VEGFA
6
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.26 BGLAP PTH RUNX2 TNFSF11
7
Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway 1
10.8 BMP2 COL2A1
8
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.75 BGLAP PTH RUNX2 TNFRSF11A TNFRSF11B TNFSF11
9
Osteoclast Signaling 1
10.66 ACP5 TNFRSF11A TNFRSF11B TNFSF11
10
Osteoblast Signaling 1
10.4 BGLAP PTH TNFRSF11B TNFSF11
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GO Terms for Ischemic Bone Disease

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Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 BGLAP BMP2 COL2A1 PTH SOST TNFRSF11B
2 extracellular matrix GO:0031012 9.46 ACAN COL2A1 TNFRSF11B VEGFA
3 extracellular region GO:0005576 9.32 ACAN BGLAP BMP2 COL2A1 EGFL8 PTH

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.93 BMP2 PTH TNFRSF11B TNFSF11 VEGFA
2 response to ethanol GO:0045471 9.79 BGLAP PTH TBXAS1
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.74 TNFRSF11A TNFRSF11B TNFSF11
4 bone development GO:0060348 9.69 BGLAP COL2A1 TNFSF11
5 bone mineralization GO:0030282 9.65 BGLAP BMP2 PTH
6 cartilage condensation GO:0001502 9.63 ACAN COL2A1
7 chondrocyte differentiation GO:0002062 9.63 BMP2 COL2A1 RUNX2
8 response to vitamin D GO:0033280 9.62 BGLAP PTH
9 osteoblast development GO:0002076 9.62 BGLAP RUNX2
10 osteoblast differentiation GO:0001649 9.62 BGLAP BMP2 RUNX2 SP7
11 positive regulation of bone resorption GO:0045780 9.61 TNFRSF11A TNFSF11
12 cellular response to BMP stimulus GO:0071773 9.61 BMP2 COL2A1 RUNX2
13 chondrocyte development GO:0002063 9.6 ACAN RUNX2
14 regulation of osteoclast differentiation GO:0045670 9.59 BGLAP TNFSF11
15 positive regulation of ossification GO:0045778 9.58 BMP2 PTH
16 response to inorganic substance GO:0010035 9.58 BGLAP TNFRSF11B
17 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.56 BMP2 RUNX2
18 proteoglycan metabolic process GO:0006029 9.55 BMP2 COL2A1
19 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.52 BMP2 RUNX2
20 skeletal system development GO:0001501 9.5 ACAN BGLAP BMP2 COL2A1 PTH RUNX2
21 TNFSF11-mediated signaling pathway GO:0071847 9.49 TNFRSF11A TNFSF11
22 bone resorption GO:0045453 9.43 ACP5 PTH TNFSF11
23 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.4 TNFRSF11A TNFSF11
24 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.37 TNFRSF11A TNFSF11
25 mammary gland alveolus development GO:0060749 9.33 TNFRSF11A TNFSF11 VEGFA
26 ossification GO:0001503 9.23 ACP5 BGLAP BMP2 COL2A1 RUNX2 SOST
27 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 BMP2 PTH RUNX2 SP7 TNFSF11 VEGFA

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 BMP2 TNFRSF11B TNFSF11 VEGFA
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Sources for Ischemic Bone Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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