MCID: ISC005
MIFTS: 29

Ischemic Bone Disease

Categories: Bone diseases

Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080008

Summaries for Ischemic Bone Disease

Disease Ontology : 12 A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteonecrosis and bone disease. An important gene associated with Ischemic Bone Disease is TBXAS1 (Thromboxane A Synthase 1), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Affiliated tissues include bone, bone and bone marrow, and related phenotypes are craniofacial and hematopoietic system

Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 27.6 ACP5 BGLAP BMP2 COL2A1 FDPS PTH
2 bone disease 27.1 ACAN ACP5 BGLAP COL2A1 PTH RUNX2
3 osteochondritis dissecans 10.9
4 osteochondrosis 10.9
5 dysbaric osteonecrosis 10.9
6 osteopetrosis, autosomal dominant 2 10.8 BGLAP TNFSF11
7 tooth ankylosis 10.7 BMP2 TNFSF11
8 multicentric reticulohistiocytosis 10.7 TNFRSF11B TNFSF11
9 kummell's disease 10.7 TNFRSF11B TNFSF11
10 periodontitis, chronic 10.7 TNFRSF11B TNFSF11
11 villonodular synovitis 10.7 ACP5 TNFSF11
12 chronic apical periodontitis 10.7 TNFRSF11B TNFSF11
13 axial osteomalacia 10.7 BGLAP PTH
14 breast leiomyosarcoma 10.7 TNFRSF11A TNFSF11
15 extraskeletal chondroma 10.7 BGLAP PTH
16 tympanosclerosis 10.6 BMP2 COL2A1
17 osseous heteroplasia, progressive 10.6 BGLAP BMP2 RUNX2
18 ossification of the posterior longitudinal ligament of spine 10.6 BGLAP BMP2 RUNX2
19 synovial chondromatosis 10.6 BMP2 COL2A1 RUNX2
20 fibrogenesis imperfecta ossium 10.6 PTH TNFRSF11B
21 alveolar periostitis 10.6 BGLAP RUNX2
22 endosteal hyperostosis, autosomal dominant 10.6 BMP2 TNFRSF11B TNFSF11
23 achondrogenesis, type ia 10.6 ACAN COL2A1
24 aortic valve disease 1 10.6 BMP2 RUNX2 TNFRSF11B
25 osteomyelitis 10.6 ACP5 BMP2 TNFSF11
26 bone deterioration disease 10.5 ACAN BMP2 COL2A1
27 bone structure disease 10.5 ACAN BMP2 COL2A1
28 polyarticular onset juvenile idiopathic arthritis 10.5 TNFRSF11A TNFRSF11B TNFSF11
29 hemophilic arthropathy 10.5 TNFRSF11A TNFRSF11B TNFSF11
30 paget disease of bone 5, juvenile-onset 10.5 TNFRSF11A TNFRSF11B TNFSF11
31 familial expansile osteolysis 10.5 TNFRSF11A TNFRSF11B TNFSF11
32 vitreoretinal dystrophy 10.4 BGLAP COL2A1
33 eye degenerative disease 10.4 COL2A1 VEGFA
34 arthropathy 10.4 ACAN TNFRSF11B TNFSF11
35 cartilage disease 10.4 ACAN COL2A1
36 differentiated thyroid carcinoma 10.4 BGLAP TNFRSF11B VEGFA
37 renal osteodystrophy 10.4 BGLAP PTH TNFRSF11B
38 brachydactyly 10.4 BMP2 COL2A1 RUNX2
39 aortic valve disease 2 10.3 BMP2 RUNX2 TNFRSF11B TNFSF11
40 periodontitis 10.3 BGLAP RUNX2 TNFRSF11B TNFSF11
41 osteochondrodysplasia 10.3 BGLAP COL2A1 SP7
42 pfeiffer syndrome 10.3 BGLAP RUNX2 SP7
43 periodontal disease 10.3 TNFRSF11A TNFRSF11B TNFSF11
44 osteitis fibrosa 10.2 BGLAP PTH
45 giant cell tumor 10.2 BGLAP TNFRSF11A TNFRSF11B TNFSF11
46 root resorption 10.2 RUNX2 TNFRSF11A TNFRSF11B TNFSF11
47 multicentric carpotarsal osteolysis syndrome 10.2 ACP5 TNFRSF11A TNFRSF11B TNFSF11
48 periapical periodontitis 10.2 ACP5 TNFRSF11A TNFRSF11B TNFSF11
49 secondary hyperparathyroidism of renal origin 10.1 ACP5 BGLAP PTH TNFRSF11B
50 hyperparathyroidism 10.1 ACP5 BGLAP PTH TNFRSF11B

Graphical network of the top 20 diseases related to Ischemic Bone Disease:



Diseases related to Ischemic Bone Disease

Symptoms & Phenotypes for Ischemic Bone Disease

MGI Mouse Phenotypes related to Ischemic Bone Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.02 TNFSF11 VEGFA BMP2 COL2A1 KLHDC2 PTH
2 hematopoietic system MP:0005397 10.02 TNFRSF11B TNFSF11 VEGFA BMP2 KLHDC2 PTH
3 immune system MP:0005387 10 BMP2 COL2A1 KLHDC2 PTH RUNX2 SERPINE1
4 limbs/digits/tail MP:0005371 9.81 BMP2 COL2A1 PTH RUNX2 SP7 TNFRSF11A
5 respiratory system MP:0005388 9.5 COL2A1 RUNX2 SERPINE1 SP7 TNFRSF11A TNFSF11
6 skeleton MP:0005390 9.28 BMP2 COL2A1 PTH RUNX2 SP7 TNFRSF11A

Drugs & Therapeutics for Ischemic Bone Disease

Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

Genetic Tests for Ischemic Bone Disease

Anatomical Context for Ischemic Bone Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

19
Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

41
Bone, Bone Marrow

Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

# Title Authors Year
1
Bone marrow edema: mild or nascent variant of ischemic bone disease. ( 18083442 )
2008

Variations for Ischemic Bone Disease

Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

Pathways for Ischemic Bone Disease

GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 BGLAP BMP2 COL2A1 PTH SERPINE1 TNFRSF11B
2 extracellular region GO:0005576 9.32 ACAN BGLAP BMP2 COL2A1 EGFL8 PTH

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.85 ACAN COL2A1 SERPINE1 TNFRSF11B
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNFRSF11A TNFRSF11B TNFSF11
3 response to ethanol GO:0045471 9.78 BGLAP PTH TBXAS1
4 regulation of signaling receptor activity GO:0010469 9.73 BMP2 PTH SERPINE1 TNFRSF11B TNFSF11 VEGFA
5 bone development GO:0060348 9.71 BGLAP COL2A1 TNFSF11
6 osteoblast differentiation GO:0001649 9.67 BGLAP BMP2 RUNX2 SP7
7 chondrocyte differentiation GO:0002062 9.65 BMP2 COL2A1 RUNX2
8 prostaglandin metabolic process GO:0006693 9.63 AKR1C1 TBXAS1
9 cellular response to BMP stimulus GO:0071773 9.63 BMP2 COL2A1 RUNX2
10 response to vitamin D GO:0033280 9.62 BGLAP PTH
11 osteoblast development GO:0002076 9.61 BGLAP RUNX2
12 positive regulation of bone resorption GO:0045780 9.6 TNFRSF11A TNFSF11
13 regulation of osteoclast differentiation GO:0045670 9.59 BGLAP TNFSF11
14 positive regulation of ossification GO:0045778 9.58 BMP2 PTH
15 response to inorganic substance GO:0010035 9.58 BGLAP TNFRSF11B
16 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.57 BMP2 RUNX2
17 proteoglycan metabolic process GO:0006029 9.56 BMP2 COL2A1
18 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.52 BMP2 RUNX2
19 bone resorption GO:0045453 9.5 ACP5 PTH TNFSF11
20 TNFSF11-mediated signaling pathway GO:0071847 9.49 TNFRSF11A TNFSF11
21 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.43 TNFRSF11A TNFSF11
22 ossification GO:0001503 9.43 BGLAP BMP2 COL2A1 RUNX2 TNFRSF11A TNFSF11
23 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.4 TNFRSF11A TNFSF11
24 mammary gland alveolus development GO:0060749 9.33 TNFRSF11A TNFSF11 VEGFA
25 skeletal system development GO:0001501 9.17 ACAN BGLAP BMP2 COL2A1 PTH RUNX2
26 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 BMP2 PTH RUNX2 SERPINE1 SP7 TNFSF11

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 BMP2 TNFRSF11B TNFSF11 VEGFA

Sources for Ischemic Bone Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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