Ischemic Bone Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080008

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Summaries for Ischemic Bone Disease

Disease Ontology : ¹² A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteonecrosis and bone disease. An important gene associated with Ischemic Bone Disease is TBXAS1 (Thromboxane A Synthase 1), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Affiliated tissues include bone, bone and bone marrow, and related phenotypes are craniofacial and hematopoietic system

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Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)

#	Related Disease	Score	Top Affiliating Genes
1	osteonecrosis	27.6	ACP5 BGLAP BMP2 COL2A1 FDPS PTH
2	bone disease	27.1	ACAN ACP5 BGLAP COL2A1 PTH RUNX2
3	osteochondritis dissecans	10.9
4	osteochondrosis	10.9
5	dysbaric osteonecrosis	10.9
6	osteopetrosis, autosomal dominant 2	10.8	BGLAP TNFSF11
7	tooth ankylosis	10.7	BMP2 TNFSF11
8	multicentric reticulohistiocytosis	10.7	TNFRSF11B TNFSF11
9	kummell's disease	10.7	TNFRSF11B TNFSF11
10	periodontitis, chronic	10.7	TNFRSF11B TNFSF11
11	villonodular synovitis	10.7	ACP5 TNFSF11
12	chronic apical periodontitis	10.7	TNFRSF11B TNFSF11
13	axial osteomalacia	10.7	BGLAP PTH
14	breast leiomyosarcoma	10.7	TNFRSF11A TNFSF11
15	extraskeletal chondroma	10.7	BGLAP PTH
16	tympanosclerosis	10.6	BMP2 COL2A1
17	osseous heteroplasia, progressive	10.6	BGLAP BMP2 RUNX2
18	ossification of the posterior longitudinal ligament of spine	10.6	BGLAP BMP2 RUNX2
19	synovial chondromatosis	10.6	BMP2 COL2A1 RUNX2
20	fibrogenesis imperfecta ossium	10.6	PTH TNFRSF11B
21	alveolar periostitis	10.6	BGLAP RUNX2
22	endosteal hyperostosis, autosomal dominant	10.6	BMP2 TNFRSF11B TNFSF11
23	achondrogenesis, type ia	10.6	ACAN COL2A1
24	aortic valve disease 1	10.6	BMP2 RUNX2 TNFRSF11B
25	osteomyelitis	10.6	ACP5 BMP2 TNFSF11
26	bone deterioration disease	10.5	ACAN BMP2 COL2A1
27	bone structure disease	10.5	ACAN BMP2 COL2A1
28	polyarticular onset juvenile idiopathic arthritis	10.5	TNFRSF11A TNFRSF11B TNFSF11
29	hemophilic arthropathy	10.5	TNFRSF11A TNFRSF11B TNFSF11
30	paget disease of bone 5, juvenile-onset	10.5	TNFRSF11A TNFRSF11B TNFSF11
31	familial expansile osteolysis	10.5	TNFRSF11A TNFRSF11B TNFSF11
32	vitreoretinal dystrophy	10.4	BGLAP COL2A1
33	eye degenerative disease	10.4	COL2A1 VEGFA
34	arthropathy	10.4	ACAN TNFRSF11B TNFSF11
35	cartilage disease	10.4	ACAN COL2A1
36	differentiated thyroid carcinoma	10.4	BGLAP TNFRSF11B VEGFA
37	renal osteodystrophy	10.4	BGLAP PTH TNFRSF11B
38	brachydactyly	10.4	BMP2 COL2A1 RUNX2
39	aortic valve disease 2	10.3	BMP2 RUNX2 TNFRSF11B TNFSF11
40	periodontitis	10.3	BGLAP RUNX2 TNFRSF11B TNFSF11
41	osteochondrodysplasia	10.3	BGLAP COL2A1 SP7
42	pfeiffer syndrome	10.3	BGLAP RUNX2 SP7
43	periodontal disease	10.3	TNFRSF11A TNFRSF11B TNFSF11
44	osteitis fibrosa	10.2	BGLAP PTH
45	giant cell tumor	10.2	BGLAP TNFRSF11A TNFRSF11B TNFSF11
46	root resorption	10.2	RUNX2 TNFRSF11A TNFRSF11B TNFSF11
47	multicentric carpotarsal osteolysis syndrome	10.2	ACP5 TNFRSF11A TNFRSF11B TNFSF11
48	periapical periodontitis	10.2	ACP5 TNFRSF11A TNFRSF11B TNFSF11
49	secondary hyperparathyroidism of renal origin	10.1	ACP5 BGLAP PTH TNFRSF11B
50	hyperparathyroidism	10.1	ACP5 BGLAP PTH TNFRSF11B

Graphical network of the top 20 diseases related to Ischemic Bone Disease:

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Symptoms & Phenotypes for Ischemic Bone Disease

MGI Mouse Phenotypes related to Ischemic Bone Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	10.02	TNFSF11 VEGFA BMP2 COL2A1 KLHDC2 PTH
2	hematopoietic system	MP:0005397	10.02	TNFRSF11B TNFSF11 VEGFA BMP2 KLHDC2 PTH
3	immune system	MP:0005387	10	BMP2 COL2A1 KLHDC2 PTH RUNX2 SERPINE1
4	limbs/digits/tail	MP:0005371	9.81	BMP2 COL2A1 PTH RUNX2 SP7 TNFRSF11A
5	respiratory system	MP:0005388	9.5	COL2A1 RUNX2 SERPINE1 SP7 TNFRSF11A TNFSF11
6	skeleton	MP:0005390	9.28	BMP2 COL2A1 PTH RUNX2 SP7 TNFRSF11A

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Drugs & Therapeutics for Ischemic Bone Disease

Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

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Genetic Tests for Ischemic Bone Disease

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Anatomical Context for Ischemic Bone Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

¹⁹

Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

⁴¹

Bone, Bone Marrow

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Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

#	Title	Authors	Year
1	Bone marrow edema: mild or nascent variant of ischemic bone disease. ( 18083442 )	Bouquot J.E....Glueck C.J.	2008

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Genes for Ischemic Bone Disease

Genes related to Ischemic Bone Disease (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TBXAS1	Thromboxane A Synthase 1	Protein Coding	17.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	BMP2	Bone Morphogenetic Protein 2	Protein Coding	17.17	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	TNFSF11	TNF Superfamily Member 11	Protein Coding	17.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	16.88	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	RUNX2	Runt Related Transcription Factor 2	Protein Coding	16.55	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	16.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	16.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	16.21	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	ACAN	Aggrecan	Protein Coding	16.09	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	15.91	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	15.67	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	PTH	Parathyroid Hormone	Protein Coding	15.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	15.53	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	SP7	Sp7 Transcription Factor	Protein Coding	15.51	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	SERPINE1	Serpin Family E Member 1	Protein Coding	15.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	EGFL8	EGF Like Domain Multiple 8	Protein Coding	8.22	DISEASES inferred ¹⁵ ¹⁵
17	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	7.45	DISEASES inferred ¹⁵
18	KLHDC2	Kelch Domain Containing 2	Protein Coding	7.16	DISEASES inferred ¹⁵

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Variations for Ischemic Bone Disease

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Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

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Pathways for Ischemic Bone Disease

Pathways related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	RANK Signaling in Osteoclasts ⁶⁴ Show member pathways Apoptosis and survival APRIL and BAFF signaling ²² APRIL Pathway ⁶⁴ BAFF in B-Cell Signaling ⁶⁴ RANK Pathway ⁶⁴ RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway ¹	12.16	ACP5 TNFRSF11A TNFRSF11B TNFSF11
2	Osteoclast differentiation ³⁷	11.84	ACP5 TNFRSF11A TNFRSF11B TNFSF11
3	Parathyroid hormone synthesis, secretion and action ³⁷	11.73	BGLAP PTH RUNX2 TNFSF11
4	Rheumatoid arthritis ³⁷	11.62	ACP5 TNFRSF11A TNFSF11 VEGFA
5	Endochondral Ossification ¹	11.47	ACAN COL2A1 PTH RUNX2 VEGFA
6	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.21	BGLAP PTH RUNX2 TNFSF11
7	Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway ¹	10.8	BMP2 COL2A1
8	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.75	BGLAP PTH RUNX2 TNFRSF11A TNFRSF11B TNFSF11
9	Osteoclast Signaling ¹	10.66	ACP5 TNFRSF11A TNFRSF11B TNFSF11
10	Osteoblast Signaling ¹	10.4	BGLAP PTH TNFRSF11B TNFSF11

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GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.56	BGLAP BMP2 COL2A1 PTH SERPINE1 TNFRSF11B
2	extracellular region	GO:0005576	9.32	ACAN BGLAP BMP2 COL2A1 EGFL8 PTH

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:0030198	9.85	ACAN COL2A1 SERPINE1 TNFRSF11B
2	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.8	TNFRSF11A TNFRSF11B TNFSF11
3	response to ethanol	GO:0045471	9.78	BGLAP PTH TBXAS1
4	regulation of signaling receptor activity	GO:0010469	9.73	BMP2 PTH SERPINE1 TNFRSF11B TNFSF11 VEGFA
5	bone development	GO:0060348	9.71	BGLAP COL2A1 TNFSF11
6	osteoblast differentiation	GO:0001649	9.67	BGLAP BMP2 RUNX2 SP7
7	chondrocyte differentiation	GO:0002062	9.65	BMP2 COL2A1 RUNX2
8	prostaglandin metabolic process	GO:0006693	9.63	AKR1C1 TBXAS1
9	cellular response to BMP stimulus	GO:0071773	9.63	BMP2 COL2A1 RUNX2
10	response to vitamin D	GO:0033280	9.62	BGLAP PTH
11	osteoblast development	GO:0002076	9.61	BGLAP RUNX2
12	positive regulation of bone resorption	GO:0045780	9.6	TNFRSF11A TNFSF11
13	regulation of osteoclast differentiation	GO:0045670	9.59	BGLAP TNFSF11
14	positive regulation of ossification	GO:0045778	9.58	BMP2 PTH
15	response to inorganic substance	GO:0010035	9.58	BGLAP TNFRSF11B
16	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO:1901522	9.57	BMP2 RUNX2
17	proteoglycan metabolic process	GO:0006029	9.56	BMP2 COL2A1
18	regulation of odontogenesis of dentin-containing tooth	GO:0042487	9.52	BMP2 RUNX2
19	bone resorption	GO:0045453	9.5	ACP5 PTH TNFSF11
20	TNFSF11-mediated signaling pathway	GO:0071847	9.49	TNFRSF11A TNFSF11
21	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	9.43	TNFRSF11A TNFSF11
22	ossification	GO:0001503	9.43	BGLAP BMP2 COL2A1 RUNX2 TNFRSF11A TNFSF11
23	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:0071848	9.4	TNFRSF11A TNFSF11
24	mammary gland alveolus development	GO:0060749	9.33	TNFRSF11A TNFSF11 VEGFA
25	skeletal system development	GO:0001501	9.17	ACAN BGLAP BMP2 COL2A1 PTH RUNX2
26	positive regulation of transcription by RNA polymerase II	GO:0045944	10.05	BMP2 PTH RUNX2 SERPINE1 SP7 TNFSF11

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	8.92	BMP2 TNFRSF11B TNFSF11 VEGFA

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Sources for Ischemic Bone Disease

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