Ischemic Bone Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ISC005 MIFTS: 29	Ischemic Bone Disease Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080008

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Summaries for Ischemic Bone Disease

Disease Ontology : ¹² A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondritis dissecans and osteonecrosis. An important gene associated with Ischemic Bone Disease is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Degradation of the extracellular matrix and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, thyroid and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)

#	Related Disease	Score	Top Affiliating Genes
1	osteochondritis dissecans	32.1	BMP7 BMP2 ACAN
2	osteonecrosis	31.3	VEGFA TNFSF11 RUNX2 PTH FDPS COL2A1
3	bone disease	28.8	VEGFA TNFSF11 SP7 SOST RUNX2 PTH
4	dysbaric osteonecrosis	11.0
5	osteochondrosis	11.0
6	substernal goiter	10.4	PTH CALCA
7	dental pulp necrosis	10.4	TNFSF11 BMP2 BGLAP
8	chondrodysplasia, blomstrand type	10.4	TNFSF11 PTH BGLAP
9	osteopetrosis, autosomal dominant 2	10.4	TNFSF11 BGLAP ACP5
10	ossification of the posterior longitudinal ligament of spine	10.4	RUNX2 BMP2 BGLAP
11	dental pulp disease	10.4	RUNX2 BMP2 BGLAP
12	malignant ovarian brenner tumor	10.4	TNFSF11 PTH CALCA
13	phosphorus metabolism disease	10.4	RUNX2 PTH BGLAP
14	paget disease of bone 5, juvenile-onset	10.4	TNFSF11 CALCA
15	osteopetrosis, autosomal recessive 2	10.4	TNFSF11 CTSK ACP5
16	hypophosphatasia	10.4	RUNX2 PTH BGLAP
17	calcific tendinitis	10.4	CTSK BMP2
18	teeth hard tissue disease	10.4	TNFSF11 BGLAP ACP5
19	giant cell reparative granuloma	10.4	TNFSF11 PTH CALCA
20	osteitis fibrosa	10.4	PTH CALCA BGLAP
21	osteopetrosis, autosomal recessive 8	10.4	TNFSF11 CTSK ACP5
22	nontoxic goiter	10.4	PTH CALCA BGLAP
23	hyperphosphatemia	10.4	RUNX2 PTH BGLAP
24	metaphyseal dysplasia	10.4	RUNX2 COL2A1 ACP5
25	kummell's disease	10.4	TNFSF11 SOST CALCA
26	bone osteosarcoma	10.4	TNFSF11 RUNX2 BGLAP
27	fibrous dysplasia	10.4	TNFSF11 CALCA BGLAP
28	spondylosis	10.4	PTH BMP2 ACAN
29	synovial chondromatosis	10.4	RUNX2 COL2A1 BMP2
30	femoral cancer	10.4	TNFSF11 ACP5
31	spondyloarthropathy 1	10.4	TNFSF11 PTH BGLAP
32	sclerosteosis 1	10.4	SP7 SOST BGLAP
33	hypocalcemia, autosomal dominant 1	10.4	PTH CALCA BGLAP
34	thyroid gland disease	10.4	PTH MIR181A1 CALCA
35	extraosseous osteosarcoma	10.4	SP7 BGLAP
36	goiter	10.4	VEGFA CALCA BGLAP
37	discitis	10.4	CALCA ACAN
38	pseudohypoparathyroidism	10.4	PTH CALCA BGLAP
39	neurogenic arthropathy	10.4	COL2A1 CALCA
40	hypoparathyroidism	10.4	PTH CALCA BGLAP
41	osteomalacia	10.4	PTH CALCA BGLAP
42	tympanosclerosis	10.4	COL2A1 CALCA BMP2
43	hemiplegia	10.4	CALCA BGLAP ACP5
44	hypervitaminosis d	10.3	PTH CALCA
45	multicentric carpotarsal osteolysis syndrome	10.3	TNFSF11 CTSK BGLAP ACP5
46	degenerative disc disease	10.3	CALCA BMP2 ACAN
47	aortic valve disease 2	10.3	TNFSF11 RUNX2 MIR21 BMP2
48	plantar fasciitis	10.3	VEGFA CALCA
49	fibrochondrogenesis	10.3	COL2A1 BMP2 ACAN
50	periapical periodontitis	10.3	TNFSF11 RUNX2 CTSK ACP5

Graphical network of the top 20 diseases related to Ischemic Bone Disease:

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Symptoms & Phenotypes for Ischemic Bone Disease

GenomeRNAi Phenotypes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-100	9.6	SP7
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-11	9.6	BMP7
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-115	9.6	FDPS
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-121	9.6	SP7
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-126	9.6	BGLAP
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-13	9.6	SP7
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-139	9.6	BMP7
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-16	9.6	BGLAP
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-18	9.6	BGLAP
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-181	9.6	BGLAP BMP7 SP7
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-198	9.6	BMP7
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-203	9.6	SP7
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-34	9.6	BMP7
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-36	9.6	SP7
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-59	9.6	SP7
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-86	9.6	BMP7
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-96	9.6	BMP7

MGI Mouse Phenotypes related to Ischemic Bone Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.76	BMP2 BMP7 COL2A1 CTSK PTH RUNX2
2	limbs/digits/tail	MP:0005371	9.65	BMP2 BMP7 COL2A1 CTSK PTH RUNX2
3	skeleton	MP:0005390	9.36	BGLAP BMP2 BMP7 COL2A1 CTSK PTH

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Drugs & Therapeutics for Ischemic Bone Disease

Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

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Genetic Tests for Ischemic Bone Disease

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Anatomical Context for Ischemic Bone Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

¹⁹

Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

⁴⁰

Bone, Thyroid, Bone Marrow, Eye, Kidney, Breast, Tongue

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Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

#	Title	Authors	PMID	Year
1	Overexpression of SIRT1 prevents hypoxia‑induced apoptosis in osteoblast cells. ⁶¹	Zhou L...Kim JR	28677728	2017
2	Bone marrow edema: mild or nascent variant of ischemic bone disease. ⁶¹	Bouquot JE...Glueck CJ	18083442	2008
3	Focal osteoporotic marrow defect: report of 100 new cases with ultrasonography scans. ⁶¹	Shankland WE...Bouquot JE	15532316	2004
4	Expression of human VEGF(121) cDNA in mouse bone marrow stromal cells. ⁶¹	Cai S...Ma D	12123565	2002
5	[Construction of adenoviral vector encoding human VEGF(121) cDNA and its expression in vitro]. ⁶¹	Cai S...Ma D	12133348	2002
6	The determination of bone viability: a histochemical method for identification of lactate dehydrogenase activity in osteocytes in fresh calcified and decalcified sections of human bone. ⁶¹	Wong SY...Hills E	6760091	1982

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Genes for Ischemic Bone Disease

Genes related to Ischemic Bone Disease (0 elite genes):

(show all 33)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TNFSF11	TNF Superfamily Member 11	Protein Coding	8.66	DISEASES inferred ¹⁵
2	MIR122	MicroRNA 122	RNA Gene	8.31	DISEASES inferred ¹⁵ ¹⁵
3	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	8.06	DISEASES inferred ¹⁵
4	MIR21	MicroRNA 21	RNA Gene	8.03	DISEASES inferred ¹⁵ ¹⁵
5	BMP2	Bone Morphogenetic Protein 2	Protein Coding	7.94	DISEASES inferred ¹⁵
6	PTH	Parathyroid Hormone	Protein Coding	7.72	DISEASES inferred ¹⁵
7	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	7.72	DISEASES inferred ¹⁵
8	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	7.68	DISEASES inferred ¹⁵
9	MIR188	MicroRNA 188	RNA Gene	7.54	DISEASES inferred ¹⁵ ¹⁵
10	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	7.49	DISEASES inferred ¹⁵
11	CTSK	Cathepsin K	Protein Coding	7.34	DISEASES inferred ¹⁵
12	SOST	Sclerostin	Protein Coding	7.32	DISEASES inferred ¹⁵
13	ACAN	Aggrecan	Protein Coding	7.17	DISEASES inferred ¹⁵
14	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	7.13	DISEASES inferred ¹⁵
15	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	7.12	DISEASES inferred ¹⁵
16	SP7	Sp7 Transcription Factor	Protein Coding	6.9	DISEASES inferred ¹⁵
17	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	6.87	DISEASES inferred ¹⁵
18	MIR181A1	MicroRNA 181a-1	RNA Gene	6.73	DISEASES inferred ¹⁵ ¹⁵
19	BMP7	Bone Morphogenetic Protein 7	Protein Coding	6.68	DISEASES inferred ¹⁵
20	MIR22	MicroRNA 22	RNA Gene	6.6	DISEASES inferred ¹⁵ ¹⁵
21	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	6.58	DISEASES inferred ¹⁵
22	SPP1	Secreted Phosphoprotein 1	Protein Coding	6.58	DISEASES inferred ¹⁵
23	IL6	Interleukin 6	Protein Coding	6.55	DISEASES inferred ¹⁵
24	TNF	Tumor Necrosis Factor	Protein Coding	6.54	DISEASES inferred ¹⁵
25	DKK1	Dickkopf WNT Signaling Pathway Inhibitor 1	Protein Coding	6.53	DISEASES inferred ¹⁵
26	GGPS1	Geranylgeranyl Diphosphate Synthase 1	Protein Coding	6.43	DISEASES inferred ¹⁵
27	IBSP	Integrin Binding Sialoprotein	Protein Coding	6.42	DISEASES inferred ¹⁵
28	IGF1	Insulin Like Growth Factor 1	Protein Coding	6.41	DISEASES inferred ¹⁵
29	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	6.33	DISEASES inferred ¹⁵
30	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	6.32	DISEASES inferred ¹⁵
31	FGF2	Fibroblast Growth Factor 2	Protein Coding	6.27	DISEASES inferred ¹⁵
32	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	6.27	DISEASES inferred ¹⁵
33	IL1B	Interleukin 1 Beta	Protein Coding	6.25	DISEASES inferred ¹⁵

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Variations for Ischemic Bone Disease

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Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

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Pathways for Ischemic Bone Disease

Pathways related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.51	CTSK COL2A1 BMP7 BMP2 ACAN
2	Parathyroid hormone synthesis, secretion and action ³⁶	11.74	TNFSF11 SOST RUNX2 PTH BGLAP
3	Rheumatoid arthritis ³⁶	11.62	VEGFA TNFSF11 PTH CTSK ACP5
4	Signaling by BMP ⁶⁵ Show member pathways BMP receptor signaling ¹ Bone Morphogenic Protein (BMP) Signalling and Regulation ¹	11.51	RUNX2 BMP7 BMP2
5	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²³	11.26	TNFSF11 RUNX2 PTH BGLAP
6	Endochondral Ossification ¹	11.25	VEGFA RUNX2 PTH COL2A1 BMP7 ACAN
7	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.21	TNFSF11 RUNX2 PTH CALCA BGLAP
8	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.2	SP7 RUNX2 PTH COL2A1 BMP7 BMP2
9	Osteoclast Signaling ¹	10.81	TNFSF11 CTSK ACP5
10	G-protein signaling_Rap2B regulation pathway ²³	10.8	TNFSF11 COL2A1 BMP7 BMP2 ACAN
11	Osteoblast Signaling ¹	10.73	TNFSF11 PTH BGLAP

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GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	VEGFA TNFSF11 SOST PTH CTSK COL2A1
2	extracellular space	GO:0005615	9.47	VEGFA TNFSF11 SOST PTH MIR22 MIR21

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.14	VEGFA TNFSF11 SP7 RUNX2 PTH BMP7
2	gene silencing by miRNA	GO:0035195	10.04	MIR22 MIR21 MIR188 MIR181A1 MIR122
3	positive regulation of cell migration	GO:0030335	9.93	VEGFA MIR21 MIR181A1 BMP2
4	positive regulation of gene expression	GO:0010628	9.93	VEGFA TNFSF11 RUNX2 MIR21 BMP7 BMP2
5	negative regulation of gene expression	GO:0010629	9.89	VEGFA PTH MIR21 MIR181A1 BMP2
6	cartilage development	GO:0051216	9.8	COL2A1 BMP7 BMP2
7	bone development	GO:0060348	9.75	TNFSF11 COL2A1 BGLAP
8	odontogenesis of dentin-containing tooth	GO:0042475	9.74	RUNX2 BMP7 BMP2
9	osteoblast differentiation	GO:0001649	9.73	SP7 RUNX2 BMP2 BGLAP
10	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.71	MIR21 BMP7 BMP2
11	BMP signaling pathway	GO:0030509	9.71	RUNX2 MIR21 BMP7 BMP2
12	chondrocyte differentiation	GO:0002062	9.7	RUNX2 COL2A1 BMP2
13	positive regulation of bone mineralization	GO:0030501	9.69	PTH BMP7 BMP2
14	positive regulation of ossification	GO:0045778	9.65	PTH BMP2
15	positive regulation of p38MAPK cascade	GO:1900745	9.65	VEGFA MIR181A1 BMP2
16	regulation of osteoclast differentiation	GO:0045670	9.64	TNFSF11 BGLAP
17	embryonic skeletal joint morphogenesis	GO:0060272	9.63	COL2A1 BMP7
18	negative regulation of cartilage development	GO:0061037	9.62	MIR21 CTSK
19	positive regulation of osteoblast differentiation	GO:0045669	9.62	RUNX2 MIR21 BMP7 BMP2
20	mesenchymal cell differentiation	GO:0048762	9.61	BMP7 BMP2
21	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO:1901522	9.61	RUNX2 BMP2
22	proteoglycan metabolic process	GO:0006029	9.6	COL2A1 BMP2
23	endocardial cushion formation	GO:0003272	9.58	BMP7 BMP2
24	mesenchyme development	GO:0060485	9.56	BMP7 BMP2
25	cellular response to BMP stimulus	GO:0071773	9.56	RUNX2 COL2A1 BMP7 BMP2
26	regulation of odontogenesis of dentin-containing tooth	GO:0042487	9.55	RUNX2 BMP2
27	response to vitamin D	GO:0033280	9.54	PTH BMP7 BGLAP
28	skeletal system development	GO:0001501	9.5	RUNX2 PTH COL2A1 BMP7 BMP2 BGLAP
29	bone resorption	GO:0045453	9.46	TNFSF11 PTH CTSK ACP5
30	ossification	GO:0001503	9.23	TNFSF11 SOST RUNX2 COL2A1 BMP7 BMP2

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.56	MIR22 MIR21 MIR188 MIR181A1
2	proteoglycan binding	GO:0043394	9.16	CTSK COL2A1
3	BMP receptor binding	GO:0070700	8.96	BMP7 BMP2
4	cytokine activity	GO:0005125	8.92	VEGFA TNFSF11 BMP7 BMP2

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Sources for Ischemic Bone Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia