Ischemic Bone Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080008

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Summaries for Ischemic Bone Disease

Disease Ontology : ¹² A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondrosis and osteonecrosis. An important gene associated with Ischemic Bone Disease is TBXAS1 (Thromboxane A Synthase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. Affiliated tissues include bone, bone and bone marrow, and related phenotypes are growth/size/body region and cellular

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Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Related Disease	Score	Top Affiliating Genes
1	osteochondrosis	31.7	COL2A1 KLHDC2 TBXAS1
2	osteonecrosis	30.0	ACP5 BGLAP BMP2 COL2A1 FDPS PTH
3	bone disease	27.9	ACAN ACP5 BGLAP COL2A1 CTSK PTH
4	osteochondritis dissecans	11.0
5	dysbaric osteonecrosis	11.0
6	bone fracture	10.4	BGLAP BMP2
7	tooth ankylosis	10.4	BMP2 TNFSF11
8	pseudoarthrosis	10.4	BMP2 PTH
9	axial osteomalacia	10.4	BGLAP PTH
10	extraskeletal chondroma	10.4	BGLAP PTH
11	multicentric reticulohistiocytosis	10.3	TNFRSF11B TNFSF11
12	villonodular synovitis	10.3	ACP5 TNFSF11
13	bone chondrosarcoma	10.3	ACAN RUNX2
14	periodontitis, chronic	10.3	TNFRSF11B TNFSF11
15	fibrogenesis imperfecta ossium	10.3	PTH TNFRSF11B
16	ossification of the posterior longitudinal ligament of spine	10.3	BGLAP BMP2 RUNX2
17	chronic apical periodontitis	10.3	TNFRSF11B TNFSF11
18	osseous heteroplasia, progressive	10.3	BGLAP BMP2 RUNX2
19	synovial chondromatosis	10.3	BMP2 COL2A1 RUNX2
20	osteopetrosis, autosomal recessive 7	10.3	TNFRSF11A TNFSF11
21	breast leiomyosarcoma	10.3	TNFRSF11A TNFSF11
22	tympanosclerosis	10.3	BMP2 COL2A1
23	arthropathy	10.3	ACAN TNFRSF11B TNFSF11
24	achondrogenesis, type ia	10.3	ACAN COL2A1
25	critical limb ischemia	10.2	TNFRSF11B VEGFA
26	bone deterioration disease	10.2	ACAN BMP2 COL2A1
27	bone structure disease	10.2	ACAN BMP2 COL2A1
28	kummell's disease	10.2	SOST TNFRSF11B TNFSF11
29	alveolar periostitis	10.2	BGLAP RUNX2
30	polyarticular onset juvenile idiopathic arthritis	10.2	TNFRSF11A TNFRSF11B TNFSF11
31	hemophilic arthropathy	10.2	TNFRSF11A TNFRSF11B TNFSF11
32	paget disease of bone 5, juvenile-onset	10.2	TNFRSF11A TNFRSF11B TNFSF11
33	familial expansile osteolysis	10.2	TNFRSF11A TNFRSF11B TNFSF11
34	impaired renal function disease	10.2	BGLAP PTH SOST
35	differentiated thyroid carcinoma	10.2	BGLAP TNFRSF11B VEGFA
36	osteoporosis, juvenile	10.2	BGLAP PTH SOST
37	aortic valve disease 2	10.2	BMP2 RUNX2 TNFRSF11B TNFSF11
38	vitreoretinal dystrophy	10.1	BGLAP COL2A1
39	eye degenerative disease	10.1	COL2A1 VEGFA
40	aortic valve disease 1	10.1	ACAN BMP2 RUNX2 TNFRSF11B
41	secondary hyperparathyroidism of renal origin	10.1	ACP5 BGLAP PTH TNFRSF11B
42	hyperparathyroidism	10.1	ACP5 BGLAP PTH TNFRSF11B
43	bone giant cell tumor	10.1	ACP5 CTSK TNFSF11
44	ischemic colitis	10.1	SERPINE1 VEGFA
45	paget's disease of bone	10.1	BGLAP TNFRSF11A TNFRSF11B TNFSF11
46	osteopetrosis	10.1	CTSK TNFRSF11A TNFSF11
47	periapical periodontitis	10.1	ACP5 TNFRSF11A TNFRSF11B TNFSF11
48	sclerosteosis 1	10.1	SOST SP7
49	periodontal disease	10.1	TNFRSF11A TNFRSF11B TNFSF11
50	arthritis	10.1	ACAN COL2A1 TNFRSF11A TNFSF11

Graphical network of the top 20 diseases related to Ischemic Bone Disease:

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Symptoms & Phenotypes for Ischemic Bone Disease

MGI Mouse Phenotypes related to Ischemic Bone Disease:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.18	BMP2 COL2A1 CTSK KLHDC2 PTH RUNX2
2	cellular	MP:0005384	10.16	BMP2 COL2A1 CTSK PTH RUNX2 SOST
3	craniofacial	MP:0005382	10.13	BMP2 COL2A1 CTSK KLHDC2 PTH RUNX2
4	hematopoietic system	MP:0005397	10.11	BMP2 CTSK KLHDC2 PTH RUNX2 SERPINE1
5	homeostasis/metabolism	MP:0005376	10.1	BMP2 COL2A1 CTSK PTH RUNX2 SERPINE1
6	immune system	MP:0005387	10.03	BMP2 COL2A1 CTSK KLHDC2 PTH RUNX2
7	limbs/digits/tail	MP:0005371	9.9	BMP2 COL2A1 CTSK PTH RUNX2 SOST
8	respiratory system	MP:0005388	9.56	COL2A1 CTSK RUNX2 SERPINE1 SP7 TNFRSF11A
9	skeleton	MP:0005390	9.36	BMP2 COL2A1 CTSK PTH RUNX2 SOST

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Drugs & Therapeutics for Ischemic Bone Disease

Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

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Genetic Tests for Ischemic Bone Disease

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Anatomical Context for Ischemic Bone Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

²⁰

Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

⁴²

Bone, Bone Marrow, Eye, Thyroid

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Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

#	Title	Authors	Year
1	Bone marrow edema: mild or nascent variant of ischemic bone disease. ( 18083442 )	Bouquot JE...Glueck CJ	2008

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Genes for Ischemic Bone Disease

Genes related to Ischemic Bone Disease (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TBXAS1	Thromboxane A Synthase 1	Protein Coding	17.32	DISEASES inferred ¹⁵
2	TNFSF11	TNF Superfamily Member 11	Protein Coding	17.22	DISEASES inferred ¹⁵
3	BMP2	Bone Morphogenetic Protein 2	Protein Coding	17.18	DISEASES inferred ¹⁵
4	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	16.87	DISEASES inferred ¹⁵
5	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	16.63	DISEASES inferred ¹⁵
6	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	16.59	DISEASES inferred ¹⁵
7	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	16.24	DISEASES inferred ¹⁵
8	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	16.2	DISEASES inferred ¹⁵
9	ACAN	Aggrecan	Protein Coding	16.11	DISEASES inferred ¹⁵
10	PTH	Parathyroid Hormone	Protein Coding	15.9	DISEASES inferred ¹⁵
11	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	15.86	DISEASES inferred ¹⁵
12	SOST	Sclerostin	Protein Coding	15.71	DISEASES inferred ¹⁵
13	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	15.67	DISEASES inferred ¹⁵
14	SERPINE1	Serpin Family E Member 1	Protein Coding	15.43	DISEASES inferred ¹⁵
15	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	15.39	DISEASES inferred ¹⁵
16	CTSK	Cathepsin K	Protein Coding	15.37	DISEASES inferred ¹⁵
17	SP7	Sp7 Transcription Factor	Protein Coding	15.35	DISEASES inferred ¹⁵
18	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	7.46	DISEASES inferred ¹⁵
19	KLHDC2	Kelch Domain Containing 2	Protein Coding	7.14	DISEASES inferred ¹⁵

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Variations for Ischemic Bone Disease

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Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

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Pathways for Ischemic Bone Disease

Pathways related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁷ Show member pathways Collagen degradation ⁶⁷ Extracellular matrix organization ⁶⁷	12.53	ACAN BMP2 COL2A1 CTSK SERPINE1
2	RANK Signaling in Osteoclasts ⁶⁵ Show member pathways Apoptosis and survival APRIL and BAFF signaling ²³ APRIL Pathway ⁶⁵ BAFF in B-Cell Signaling ⁶⁵ RANK Pathway ⁶⁵ RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway ¹	12.25	ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
3	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²³ Show member pathways Activation of the AP-1 family of transcription factors ⁶⁷ Immune response Oncostatin M signaling via MAPK in human cells ²³ MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	12.05	SERPINE1 TNFRSF11A TNFSF11 VEGFA
4	Osteoclast differentiation ³⁸	11.94	ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
5	Parathyroid hormone synthesis, secretion and action ³⁸	11.79	BGLAP PTH RUNX2 SOST TNFSF11
6	Rheumatoid arthritis ³⁸	11.68	ACP5 CTSK TNFRSF11A TNFSF11 VEGFA
7	Endochondral Ossification ¹	11.47	ACAN COL2A1 PTH RUNX2 VEGFA
8	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²³	11.3	BGLAP PTH RUNX2 TNFSF11
9	Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway ¹	10.83	BMP2 COL2A1
10	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	10.75	BGLAP PTH RUNX2 TNFRSF11A TNFRSF11B TNFSF11
11	Osteoblast Signaling ¹	10.6	BGLAP PTH TNFRSF11B TNFSF11
12	Osteoclast Signaling ¹	10.56	ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11

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GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.65	BGLAP BMP2 COL2A1 CTSK PTH SERPINE1
2	extracellular matrix	GO:0031012	9.56	ACAN COL2A1 TNFRSF11B VEGFA
3	collagen-containing extracellular matrix	GO:0062023	9.46	ACAN COL2A1 SERPINE1 SOST
4	extracellular region	GO:0005576	9.36	ACAN BGLAP BMP2 COL2A1 CTSK PTH

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:0030198	9.86	ACAN COL2A1 SERPINE1 TNFRSF11B
2	response to ethanol	GO:0045471	9.8	BGLAP PTH TBXAS1
3	regulation of signaling receptor activity	GO:0010469	9.8	BMP2 PTH SERPINE1 TNFRSF11B TNFSF11 VEGFA
4	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.76	TNFRSF11A TNFRSF11B TNFSF11
5	bone development	GO:0060348	9.7	BGLAP COL2A1 TNFSF11
6	osteoblast differentiation	GO:0001649	9.67	BGLAP BMP2 RUNX2 SP7
7	chondrocyte differentiation	GO:0002062	9.65	BMP2 COL2A1 RUNX2
8	cartilage condensation	GO:0001502	9.64	ACAN COL2A1
9	response to vitamin D	GO:0033280	9.63	BGLAP PTH
10	osteoblast development	GO:0002076	9.63	BGLAP RUNX2
11	cellular response to BMP stimulus	GO:0071773	9.63	BMP2 COL2A1 RUNX2
12	positive regulation of bone resorption	GO:0045780	9.62	TNFRSF11A TNFSF11
13	chondrocyte development	GO:0002063	9.61	ACAN RUNX2
14	regulation of osteoclast differentiation	GO:0045670	9.61	BGLAP TNFSF11
15	positive regulation of ossification	GO:0045778	9.6	BMP2 PTH
16	response to inorganic substance	GO:0010035	9.59	BGLAP TNFRSF11B
17	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO:1901522	9.58	BMP2 RUNX2
18	proteoglycan metabolic process	GO:0006029	9.57	BMP2 COL2A1
19	regulation of odontogenesis of dentin-containing tooth	GO:0042487	9.54	BMP2 RUNX2
20	TNFSF11-mediated signaling pathway	GO:0071847	9.51	TNFRSF11A TNFSF11
21	skeletal system development	GO:0001501	9.5	ACAN BGLAP BMP2 COL2A1 PTH RUNX2
22	bone mineralization	GO:0030282	9.49	BGLAP BMP2
23	bone resorption	GO:0045453	9.46	ACP5 CTSK PTH TNFSF11
24	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:0071848	9.43	TNFRSF11A TNFSF11
25	mammary gland alveolus development	GO:0060749	9.43	TNFRSF11A TNFSF11 VEGFA
26	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	9.4	TNFRSF11A TNFSF11
27	ossification	GO:0001503	9.23	ACP5 BGLAP BMP2 COL2A1 RUNX2 SOST
28	positive regulation of transcription by RNA polymerase II	GO:0045944	10.09	BMP2 PTH RUNX2 SERPINE1 SP7 TNFSF11

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	8.92	BMP2 TNFRSF11B TNFSF11 VEGFA

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Sources for Ischemic Bone Disease

¹ BioSystems

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²¹ GeneAnalytics

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