MCID: ISC005
MIFTS: 29

Ischemic Bone Disease

Categories: Bone diseases

Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080008

Summaries for Ischemic Bone Disease

Disease Ontology : 12 A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondritis dissecans and osteonecrosis. An important gene associated with Ischemic Bone Disease is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Degradation of the extracellular matrix and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, thyroid and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 osteochondritis dissecans 32.1 BMP7 BMP2 ACAN
2 osteonecrosis 31.3 VEGFA TNFSF11 RUNX2 PTH FDPS COL2A1
3 bone disease 28.8 VEGFA TNFSF11 SP7 SOST RUNX2 PTH
4 dysbaric osteonecrosis 11.0
5 osteochondrosis 11.0
6 substernal goiter 10.4 PTH CALCA
7 dental pulp necrosis 10.4 TNFSF11 BMP2 BGLAP
8 chondrodysplasia, blomstrand type 10.4 TNFSF11 PTH BGLAP
9 osteopetrosis, autosomal dominant 2 10.4 TNFSF11 BGLAP ACP5
10 ossification of the posterior longitudinal ligament of spine 10.4 RUNX2 BMP2 BGLAP
11 dental pulp disease 10.4 RUNX2 BMP2 BGLAP
12 malignant ovarian brenner tumor 10.4 TNFSF11 PTH CALCA
13 phosphorus metabolism disease 10.4 RUNX2 PTH BGLAP
14 paget disease of bone 5, juvenile-onset 10.4 TNFSF11 CALCA
15 osteopetrosis, autosomal recessive 2 10.4 TNFSF11 CTSK ACP5
16 hypophosphatasia 10.4 RUNX2 PTH BGLAP
17 calcific tendinitis 10.4 CTSK BMP2
18 teeth hard tissue disease 10.4 TNFSF11 BGLAP ACP5
19 giant cell reparative granuloma 10.4 TNFSF11 PTH CALCA
20 osteitis fibrosa 10.4 PTH CALCA BGLAP
21 osteopetrosis, autosomal recessive 8 10.4 TNFSF11 CTSK ACP5
22 nontoxic goiter 10.4 PTH CALCA BGLAP
23 hyperphosphatemia 10.4 RUNX2 PTH BGLAP
24 metaphyseal dysplasia 10.4 RUNX2 COL2A1 ACP5
25 kummell's disease 10.4 TNFSF11 SOST CALCA
26 bone osteosarcoma 10.4 TNFSF11 RUNX2 BGLAP
27 fibrous dysplasia 10.4 TNFSF11 CALCA BGLAP
28 spondylosis 10.4 PTH BMP2 ACAN
29 synovial chondromatosis 10.4 RUNX2 COL2A1 BMP2
30 femoral cancer 10.4 TNFSF11 ACP5
31 spondyloarthropathy 1 10.4 TNFSF11 PTH BGLAP
32 sclerosteosis 1 10.4 SP7 SOST BGLAP
33 hypocalcemia, autosomal dominant 1 10.4 PTH CALCA BGLAP
34 thyroid gland disease 10.4 PTH MIR181A1 CALCA
35 extraosseous osteosarcoma 10.4 SP7 BGLAP
36 goiter 10.4 VEGFA CALCA BGLAP
37 discitis 10.4 CALCA ACAN
38 pseudohypoparathyroidism 10.4 PTH CALCA BGLAP
39 neurogenic arthropathy 10.4 COL2A1 CALCA
40 hypoparathyroidism 10.4 PTH CALCA BGLAP
41 osteomalacia 10.4 PTH CALCA BGLAP
42 tympanosclerosis 10.4 COL2A1 CALCA BMP2
43 hemiplegia 10.4 CALCA BGLAP ACP5
44 hypervitaminosis d 10.3 PTH CALCA
45 multicentric carpotarsal osteolysis syndrome 10.3 TNFSF11 CTSK BGLAP ACP5
46 degenerative disc disease 10.3 CALCA BMP2 ACAN
47 aortic valve disease 2 10.3 TNFSF11 RUNX2 MIR21 BMP2
48 plantar fasciitis 10.3 VEGFA CALCA
49 fibrochondrogenesis 10.3 COL2A1 BMP2 ACAN
50 periapical periodontitis 10.3 TNFSF11 RUNX2 CTSK ACP5

Graphical network of the top 20 diseases related to Ischemic Bone Disease:



Diseases related to Ischemic Bone Disease

Symptoms & Phenotypes for Ischemic Bone Disease

GenomeRNAi Phenotypes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 9.6 SP7
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.6 BMP7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.6 FDPS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 9.6 SP7
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.6 BGLAP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-13 9.6 SP7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.6 BMP7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.6 BGLAP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.6 BGLAP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.6 BGLAP BMP7 SP7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.6 BMP7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.6 SP7
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.6 BMP7
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-36 9.6 SP7
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.6 SP7
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.6 BMP7
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-96 9.6 BMP7

MGI Mouse Phenotypes related to Ischemic Bone Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 BMP2 BMP7 COL2A1 CTSK PTH RUNX2
2 limbs/digits/tail MP:0005371 9.65 BMP2 BMP7 COL2A1 CTSK PTH RUNX2
3 skeleton MP:0005390 9.36 BGLAP BMP2 BMP7 COL2A1 CTSK PTH

Drugs & Therapeutics for Ischemic Bone Disease

Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

Genetic Tests for Ischemic Bone Disease

Anatomical Context for Ischemic Bone Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

19
Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

40
Bone, Thyroid, Bone Marrow, Eye, Kidney, Breast, Tongue

Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

# Title Authors PMID Year
1
Overexpression of SIRT1 prevents hypoxia‑induced apoptosis in osteoblast cells. 61
28677728 2017
2
Bone marrow edema: mild or nascent variant of ischemic bone disease. 61
18083442 2008
3
Focal osteoporotic marrow defect: report of 100 new cases with ultrasonography scans. 61
15532316 2004
4
Expression of human VEGF(121) cDNA in mouse bone marrow stromal cells. 61
12123565 2002
5
[Construction of adenoviral vector encoding human VEGF(121) cDNA and its expression in vitro]. 61
12133348 2002
6
The determination of bone viability: a histochemical method for identification of lactate dehydrogenase activity in osteocytes in fresh calcified and decalcified sections of human bone. 61
6760091 1982

Variations for Ischemic Bone Disease

Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

Pathways for Ischemic Bone Disease

GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 VEGFA TNFSF11 SOST PTH CTSK COL2A1
2 extracellular space GO:0005615 9.47 VEGFA TNFSF11 SOST PTH MIR22 MIR21

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 VEGFA TNFSF11 SP7 RUNX2 PTH BMP7
2 gene silencing by miRNA GO:0035195 10.04 MIR22 MIR21 MIR188 MIR181A1 MIR122
3 positive regulation of cell migration GO:0030335 9.93 VEGFA MIR21 MIR181A1 BMP2
4 positive regulation of gene expression GO:0010628 9.93 VEGFA TNFSF11 RUNX2 MIR21 BMP7 BMP2
5 negative regulation of gene expression GO:0010629 9.89 VEGFA PTH MIR21 MIR181A1 BMP2
6 cartilage development GO:0051216 9.8 COL2A1 BMP7 BMP2
7 bone development GO:0060348 9.75 TNFSF11 COL2A1 BGLAP
8 odontogenesis of dentin-containing tooth GO:0042475 9.74 RUNX2 BMP7 BMP2
9 osteoblast differentiation GO:0001649 9.73 SP7 RUNX2 BMP2 BGLAP
10 positive regulation of epithelial to mesenchymal transition GO:0010718 9.71 MIR21 BMP7 BMP2
11 BMP signaling pathway GO:0030509 9.71 RUNX2 MIR21 BMP7 BMP2
12 chondrocyte differentiation GO:0002062 9.7 RUNX2 COL2A1 BMP2
13 positive regulation of bone mineralization GO:0030501 9.69 PTH BMP7 BMP2
14 positive regulation of ossification GO:0045778 9.65 PTH BMP2
15 positive regulation of p38MAPK cascade GO:1900745 9.65 VEGFA MIR181A1 BMP2
16 regulation of osteoclast differentiation GO:0045670 9.64 TNFSF11 BGLAP
17 embryonic skeletal joint morphogenesis GO:0060272 9.63 COL2A1 BMP7
18 negative regulation of cartilage development GO:0061037 9.62 MIR21 CTSK
19 positive regulation of osteoblast differentiation GO:0045669 9.62 RUNX2 MIR21 BMP7 BMP2
20 mesenchymal cell differentiation GO:0048762 9.61 BMP7 BMP2
21 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.61 RUNX2 BMP2
22 proteoglycan metabolic process GO:0006029 9.6 COL2A1 BMP2
23 endocardial cushion formation GO:0003272 9.58 BMP7 BMP2
24 mesenchyme development GO:0060485 9.56 BMP7 BMP2
25 cellular response to BMP stimulus GO:0071773 9.56 RUNX2 COL2A1 BMP7 BMP2
26 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.55 RUNX2 BMP2
27 response to vitamin D GO:0033280 9.54 PTH BMP7 BGLAP
28 skeletal system development GO:0001501 9.5 RUNX2 PTH COL2A1 BMP7 BMP2 BGLAP
29 bone resorption GO:0045453 9.46 TNFSF11 PTH CTSK ACP5
30 ossification GO:0001503 9.23 TNFSF11 SOST RUNX2 COL2A1 BMP7 BMP2

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.56 MIR22 MIR21 MIR188 MIR181A1
2 proteoglycan binding GO:0043394 9.16 CTSK COL2A1
3 BMP receptor binding GO:0070700 8.96 BMP7 BMP2
4 cytokine activity GO:0005125 8.92 VEGFA TNFSF11 BMP7 BMP2

Sources for Ischemic Bone Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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