MCID: ISC005
MIFTS: 30

Ischemic Bone Disease

Categories: Bone diseases

Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080008

Summaries for Ischemic Bone Disease

Disease Ontology : 12 A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondrosis and osteonecrosis. An important gene associated with Ischemic Bone Disease is TBXAS1 (Thromboxane A Synthase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. Affiliated tissues include bone, bone and bone marrow, and related phenotypes are growth/size/body region and cellular

Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 osteochondrosis 31.7 COL2A1 KLHDC2 TBXAS1
2 osteonecrosis 30.0 ACP5 BGLAP BMP2 COL2A1 FDPS PTH
3 bone disease 27.9 ACAN ACP5 BGLAP COL2A1 CTSK PTH
4 osteochondritis dissecans 11.0
5 dysbaric osteonecrosis 11.0
6 bone fracture 10.4 BGLAP BMP2
7 tooth ankylosis 10.4 BMP2 TNFSF11
8 pseudoarthrosis 10.4 BMP2 PTH
9 axial osteomalacia 10.4 BGLAP PTH
10 extraskeletal chondroma 10.4 BGLAP PTH
11 multicentric reticulohistiocytosis 10.3 TNFRSF11B TNFSF11
12 villonodular synovitis 10.3 ACP5 TNFSF11
13 bone chondrosarcoma 10.3 ACAN RUNX2
14 periodontitis, chronic 10.3 TNFRSF11B TNFSF11
15 fibrogenesis imperfecta ossium 10.3 PTH TNFRSF11B
16 ossification of the posterior longitudinal ligament of spine 10.3 BGLAP BMP2 RUNX2
17 chronic apical periodontitis 10.3 TNFRSF11B TNFSF11
18 osseous heteroplasia, progressive 10.3 BGLAP BMP2 RUNX2
19 synovial chondromatosis 10.3 BMP2 COL2A1 RUNX2
20 osteopetrosis, autosomal recessive 7 10.3 TNFRSF11A TNFSF11
21 breast leiomyosarcoma 10.3 TNFRSF11A TNFSF11
22 tympanosclerosis 10.3 BMP2 COL2A1
23 arthropathy 10.3 ACAN TNFRSF11B TNFSF11
24 achondrogenesis, type ia 10.3 ACAN COL2A1
25 critical limb ischemia 10.2 TNFRSF11B VEGFA
26 bone deterioration disease 10.2 ACAN BMP2 COL2A1
27 bone structure disease 10.2 ACAN BMP2 COL2A1
28 kummell's disease 10.2 SOST TNFRSF11B TNFSF11
29 alveolar periostitis 10.2 BGLAP RUNX2
30 polyarticular onset juvenile idiopathic arthritis 10.2 TNFRSF11A TNFRSF11B TNFSF11
31 hemophilic arthropathy 10.2 TNFRSF11A TNFRSF11B TNFSF11
32 paget disease of bone 5, juvenile-onset 10.2 TNFRSF11A TNFRSF11B TNFSF11
33 familial expansile osteolysis 10.2 TNFRSF11A TNFRSF11B TNFSF11
34 impaired renal function disease 10.2 BGLAP PTH SOST
35 differentiated thyroid carcinoma 10.2 BGLAP TNFRSF11B VEGFA
36 osteoporosis, juvenile 10.2 BGLAP PTH SOST
37 aortic valve disease 2 10.2 BMP2 RUNX2 TNFRSF11B TNFSF11
38 vitreoretinal dystrophy 10.1 BGLAP COL2A1
39 eye degenerative disease 10.1 COL2A1 VEGFA
40 aortic valve disease 1 10.1 ACAN BMP2 RUNX2 TNFRSF11B
41 secondary hyperparathyroidism of renal origin 10.1 ACP5 BGLAP PTH TNFRSF11B
42 hyperparathyroidism 10.1 ACP5 BGLAP PTH TNFRSF11B
43 bone giant cell tumor 10.1 ACP5 CTSK TNFSF11
44 ischemic colitis 10.1 SERPINE1 VEGFA
45 paget's disease of bone 10.1 BGLAP TNFRSF11A TNFRSF11B TNFSF11
46 osteopetrosis 10.1 CTSK TNFRSF11A TNFSF11
47 periapical periodontitis 10.1 ACP5 TNFRSF11A TNFRSF11B TNFSF11
48 sclerosteosis 1 10.1 SOST SP7
49 periodontal disease 10.1 TNFRSF11A TNFRSF11B TNFSF11
50 arthritis 10.1 ACAN COL2A1 TNFRSF11A TNFSF11

Graphical network of the top 20 diseases related to Ischemic Bone Disease:



Diseases related to Ischemic Bone Disease

Symptoms & Phenotypes for Ischemic Bone Disease

MGI Mouse Phenotypes related to Ischemic Bone Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.18 BMP2 COL2A1 CTSK KLHDC2 PTH RUNX2
2 cellular MP:0005384 10.16 BMP2 COL2A1 CTSK PTH RUNX2 SOST
3 craniofacial MP:0005382 10.13 BMP2 COL2A1 CTSK KLHDC2 PTH RUNX2
4 hematopoietic system MP:0005397 10.11 BMP2 CTSK KLHDC2 PTH RUNX2 SERPINE1
5 homeostasis/metabolism MP:0005376 10.1 BMP2 COL2A1 CTSK PTH RUNX2 SERPINE1
6 immune system MP:0005387 10.03 BMP2 COL2A1 CTSK KLHDC2 PTH RUNX2
7 limbs/digits/tail MP:0005371 9.9 BMP2 COL2A1 CTSK PTH RUNX2 SOST
8 respiratory system MP:0005388 9.56 COL2A1 CTSK RUNX2 SERPINE1 SP7 TNFRSF11A
9 skeleton MP:0005390 9.36 BMP2 COL2A1 CTSK PTH RUNX2 SOST

Drugs & Therapeutics for Ischemic Bone Disease

Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

Genetic Tests for Ischemic Bone Disease

Anatomical Context for Ischemic Bone Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

20
Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

42
Bone, Bone Marrow, Eye, Thyroid

Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

# Title Authors Year
1
Bone marrow edema: mild or nascent variant of ischemic bone disease. ( 18083442 )
2008

Variations for Ischemic Bone Disease

Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

Pathways for Ischemic Bone Disease

Pathways related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 ACAN BMP2 COL2A1 CTSK SERPINE1
2
Show member pathways
12.25 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.05 SERPINE1 TNFRSF11A TNFSF11 VEGFA
4 11.94 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
5 11.79 BGLAP PTH RUNX2 SOST TNFSF11
6 11.68 ACP5 CTSK TNFRSF11A TNFSF11 VEGFA
7 11.47 ACAN COL2A1 PTH RUNX2 VEGFA
8 11.3 BGLAP PTH RUNX2 TNFSF11
9 10.83 BMP2 COL2A1
10 10.75 BGLAP PTH RUNX2 TNFRSF11A TNFRSF11B TNFSF11
11 10.6 BGLAP PTH TNFRSF11B TNFSF11
12 10.56 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 BGLAP BMP2 COL2A1 CTSK PTH SERPINE1
2 extracellular matrix GO:0031012 9.56 ACAN COL2A1 TNFRSF11B VEGFA
3 collagen-containing extracellular matrix GO:0062023 9.46 ACAN COL2A1 SERPINE1 SOST
4 extracellular region GO:0005576 9.36 ACAN BGLAP BMP2 COL2A1 CTSK PTH

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.86 ACAN COL2A1 SERPINE1 TNFRSF11B
2 response to ethanol GO:0045471 9.8 BGLAP PTH TBXAS1
3 regulation of signaling receptor activity GO:0010469 9.8 BMP2 PTH SERPINE1 TNFRSF11B TNFSF11 VEGFA
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.76 TNFRSF11A TNFRSF11B TNFSF11
5 bone development GO:0060348 9.7 BGLAP COL2A1 TNFSF11
6 osteoblast differentiation GO:0001649 9.67 BGLAP BMP2 RUNX2 SP7
7 chondrocyte differentiation GO:0002062 9.65 BMP2 COL2A1 RUNX2
8 cartilage condensation GO:0001502 9.64 ACAN COL2A1
9 response to vitamin D GO:0033280 9.63 BGLAP PTH
10 osteoblast development GO:0002076 9.63 BGLAP RUNX2
11 cellular response to BMP stimulus GO:0071773 9.63 BMP2 COL2A1 RUNX2
12 positive regulation of bone resorption GO:0045780 9.62 TNFRSF11A TNFSF11
13 chondrocyte development GO:0002063 9.61 ACAN RUNX2
14 regulation of osteoclast differentiation GO:0045670 9.61 BGLAP TNFSF11
15 positive regulation of ossification GO:0045778 9.6 BMP2 PTH
16 response to inorganic substance GO:0010035 9.59 BGLAP TNFRSF11B
17 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.58 BMP2 RUNX2
18 proteoglycan metabolic process GO:0006029 9.57 BMP2 COL2A1
19 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.54 BMP2 RUNX2
20 TNFSF11-mediated signaling pathway GO:0071847 9.51 TNFRSF11A TNFSF11
21 skeletal system development GO:0001501 9.5 ACAN BGLAP BMP2 COL2A1 PTH RUNX2
22 bone mineralization GO:0030282 9.49 BGLAP BMP2
23 bone resorption GO:0045453 9.46 ACP5 CTSK PTH TNFSF11
24 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.43 TNFRSF11A TNFSF11
25 mammary gland alveolus development GO:0060749 9.43 TNFRSF11A TNFSF11 VEGFA
26 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.4 TNFRSF11A TNFSF11
27 ossification GO:0001503 9.23 ACP5 BGLAP BMP2 COL2A1 RUNX2 SOST
28 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 BMP2 PTH RUNX2 SERPINE1 SP7 TNFSF11

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 BMP2 TNFRSF11B TNFSF11 VEGFA

Sources for Ischemic Bone Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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