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MCID: ISC005
MIFTS: 27

Ischemic Bone Disease

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Ischemic Bone Disease

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MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease 12 15

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0080008
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Summaries for Ischemic Bone Disease

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Disease Ontology : 12 A bone disease that results in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondritis dissecans and osteochondrosis. An important gene associated with Ischemic Bone Disease is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Affiliated tissues include bone and bone marrow, and related phenotypes are craniofacial and limbs/digits/tail

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Related Diseases for Ischemic Bone Disease

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Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 osteochondritis dissecans 32.5 COL2A1 BMP2 ACAN
2 osteochondrosis 32.4 HECTD4 COL2A1 ACAN
3 osteonecrosis 31.5 VEGFA TNFSF11 TNFRSF11B RUNX2 PTH FDPS
4 bone disease 28.4 VEGFA TNFSF11 TNFRSF11B SP7 SOST RUNX2
5 dysbaric osteonecrosis 11.2
6 polyarticular onset juvenile idiopathic arthritis 10.6 TNFSF11 TNFRSF11B
7 villonodular synovitis 10.6 TNFSF11 ACP5
8 hemophilic arthropathy 10.6 TNFSF11 TNFRSF11B
9 periodontitis, chronic 10.6 TNFSF11 TNFRSF11B
10 dental pulp necrosis 10.6 TNFSF11 BMP2 BGLAP
11 osteopetrosis, autosomal dominant 2 10.6 TNFSF11 BGLAP ACP5
12 chondrodysplasia, blomstrand type 10.6 TNFSF11 PTH BGLAP
13 ossification of the posterior longitudinal ligament of spine 10.6 RUNX2 BMP2 BGLAP
14 multicentric reticulohistiocytosis 10.6 TNFSF11 TNFRSF11B
15 avascular necrosis 10.6 COL2A1 BMP2
16 dental pulp disease 10.6 RUNX2 BMP2 BGLAP
17 substernal goiter 10.6 PTH CALCA
18 malignant ovarian brenner tumor 10.6 TNFSF11 PTH CALCA
19 disseminated chorioretinitis 10.6 TNFSF11 TNFRSF11B
20 pigmented villonodular synovitis 10.5 TNFSF11 TNFRSF11B ACP5
21 paget disease of bone 5, juvenile-onset 10.5 TNFSF11 TNFRSF11B CALCA
22 kummell's disease 10.5 TNFSF11 TNFRSF11B SOST
23 osteopetrosis, autosomal recessive 2 10.5 TNFSF11 CTSK ACP5
24 synovial chondromatosis 10.5 RUNX2 COL2A1 BMP2
25 metaphyseal dysplasia 10.5 RUNX2 COL2A1 ACP5
26 phosphorus metabolism disease 10.5 RUNX2 PTH BGLAP
27 giant cell reparative granuloma 10.5 TNFSF11 PTH CALCA
28 nontoxic goiter 10.5 PTH CALCA BGLAP
29 hypophosphatasia 10.5 RUNX2 PTH BGLAP
30 poems syndrome 10.5 VEGFA TNFSF11 TNFRSF11B
31 chronic recurrent multifocal osteomyelitis 10.5 TNFSF11 HECTD4 BGLAP
32 teeth hard tissue disease 10.5 TNFSF11 TNFRSF11B ACP5
33 tympanosclerosis 10.5 COL2A1 CALCA BMP2
34 peroneal nerve paralysis 10.5 HECTD4 COL2A1
35 sclerosteosis 1 10.5 SP7 SOST BGLAP
36 radiculopathy 10.5 HECTD4 BMP2 ACAN
37 spondylosis 10.5 PTH HECTD4 BMP2
38 kohler's disease 10.5 HECTD4 COL2A1
39 hypocalcemia, autosomal dominant 1 10.5 PTH CALCA BGLAP
40 fibrochondrogenesis 10.5 COL2A1 BMP2 ACAN
41 spondyloarthropathy 1 10.5 TNFSF11 TNFRSF11B PTH BGLAP
42 cholesteatoma of middle ear 10.5 TNFSF11 TNFRSF11B MIR21
43 goiter 10.5 VEGFA CALCA BGLAP
44 hypercalcemia, infantile, 1 10.5 PTH CALCA
45 osseous heteroplasia, progressive 10.5 RUNX2 PTH BMP2 BGLAP
46 neurogenic arthropathy 10.5 HECTD4 CALCA
47 differentiated thyroid carcinoma 10.5 VEGFA TNFRSF11B BGLAP
48 pseudohypoparathyroidism 10.5 PTH CALCA BGLAP
49 hypoparathyroidism 10.5 PTH CALCA BGLAP
50 aneurysmal bone cysts 10.5 TNFSF11 CALCA

Graphical network of the top 20 diseases related to Ischemic Bone Disease:



Diseases related to Ischemic Bone Disease
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Symptoms & Phenotypes for Ischemic Bone Disease

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MGI Mouse Phenotypes related to Ischemic Bone Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 BMP2 COL2A1 CTSK PTH RUNX2 TNFRSF11B
2 limbs/digits/tail MP:0005371 9.65 BMP2 COL2A1 CTSK PTH RUNX2 SOST
3 skeleton MP:0005390 9.36 BGLAP BMP2 COL2A1 CTSK PTH RUNX2
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Drugs & Therapeutics for Ischemic Bone Disease

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Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

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Genetic Tests for Ischemic Bone Disease

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Anatomical Context for Ischemic Bone Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

19
Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

40
Bone, Bone Marrow
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Publications for Ischemic Bone Disease

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Articles related to Ischemic Bone Disease:

# Title Authors PMID Year
1
Overexpression of SIRT1 prevents hypoxia‑induced apoptosis in osteoblast cells. 61
28677728 2017
2
Bone marrow edema: mild or nascent variant of ischemic bone disease. 61
18083442 2008
3
Focal osteoporotic marrow defect: report of 100 new cases with ultrasonography scans. 61
15532316 2004
4
Expression of human VEGF(121) cDNA in mouse bone marrow stromal cells. 61
12123565 2002
5
[Construction of adenoviral vector encoding human VEGF(121) cDNA and its expression in vitro]. 61
12133348 2002
6
The determination of bone viability: a histochemical method for identification of lactate dehydrogenase activity in osteocytes in fresh calcified and decalcified sections of human bone. 61
6760091 1982
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Variations for Ischemic Bone Disease

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Expression for Ischemic Bone Disease

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Search GEO for disease gene expression data for Ischemic Bone Disease.
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Pathways for Ischemic Bone Disease

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Pathways related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
RANK Signaling in Osteoclasts 63
Show member pathways
 12.18 TNFSF11 TNFRSF11B CTSK ACP5
2
Osteoclast differentiation 36
11.87 TNFSF11 TNFRSF11B CTSK ACP5
3
Parathyroid hormone synthesis, secretion and action 36
11.83 TNFSF11 SOST RUNX2 PTH BGLAP
4
Rheumatoid arthritis 36
11.73 VEGFA TNFSF11 PTH CTSK ACP5
5
Endochondral Ossification 1
11.53 VEGFA RUNX2 PTH COL2A1 ACAN
6
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.32 TNFSF11 RUNX2 PTH BGLAP
7
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.15 SP7 RUNX2 PTH COL2A1 BMP2 BGLAP
8
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.09 TNFSF11 TNFRSF11B RUNX2 PTH CALCA BGLAP
9
Osteoclast Signaling 1
10.76 TNFSF11 TNFRSF11B CTSK ACP5
10
Osteoblast Signaling 1
10.6 TNFSF11 TNFRSF11B PTH BGLAP
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GO Terms for Ischemic Bone Disease

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Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 VEGFA TNFSF11 TNFRSF11B SOST PTH CTSK
2 extracellular matrix GO:0031012 9.46 VEGFA TNFRSF11B COL2A1 ACAN
3 extracellular space GO:0005615 9.44 VEGFA TNFSF11 TNFRSF11B SOST PTH MIR22

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.92 VEGFA TNFSF11 RUNX2 MIR21 BMP2
2 BMP signaling pathway GO:0030509 9.71 RUNX2 MIR21 BMP2
3 positive regulation of osteoblast differentiation GO:0045669 9.63 RUNX2 MIR21 BMP2
4 bone development GO:0060348 9.61 TNFSF11 COL2A1 BGLAP
5 response to inorganic substance GO:0010035 9.58 TNFRSF11B BGLAP
6 negative regulation of bone resorption GO:0045779 9.57 TNFRSF11B CALCA
7 positive regulation of ossification GO:0045778 9.56 PTH BMP2
8 osteoblast differentiation GO:0001649 9.56 SP7 RUNX2 BMP2 BGLAP
9 regulation of osteoclast differentiation GO:0045670 9.55 TNFSF11 BGLAP
10 chondrocyte differentiation GO:0002062 9.54 RUNX2 COL2A1 BMP2
11 negative regulation of cartilage development GO:0061037 9.51 MIR21 CTSK
12 cellular response to BMP stimulus GO:0071773 9.5 RUNX2 COL2A1 BMP2
13 skeletal system development GO:0001501 9.5 TNFRSF11B RUNX2 PTH COL2A1 BMP2 BGLAP
14 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.49 RUNX2 BMP2
15 proteoglycan metabolic process GO:0006029 9.48 COL2A1 BMP2
16 bone resorption GO:0045453 9.46 TNFSF11 PTH CTSK ACP5
17 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.4 RUNX2 BMP2
18 ossification GO:0001503 9.17 TNFSF11 SOST RUNX2 COL2A1 BMP2 BGLAP

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteoglycan binding GO:0043394 8.96 CTSK COL2A1
2 cytokine activity GO:0005125 8.92 VEGFA TNFSF11 TNFRSF11B BMP2
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Sources for Ischemic Bone Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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