MCID: ISC015
MIFTS: 48

Ischemic Colitis

Categories: Blood diseases, Gastrointestinal diseases

Aliases & Classifications for Ischemic Colitis

MalaCards integrated aliases for Ischemic Colitis:

Name: Ischemic Colitis 12 15
Colitis, Ischemic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060181
ICD10 33 K55.9
MeSH 44 D017091
SNOMED-CT 68 30588004
UMLS 73 C0162529

Summaries for Ischemic Colitis

Disease Ontology : 12 A colitis caused_by inadequate blood supply to the colon.

MalaCards based summary : Ischemic Colitis, also known as colitis, ischemic, is related to arteriovenous fistula and arteriovenous malformation. An important gene associated with Ischemic Colitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Coal tar and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include colon, myeloid and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and... more...

Related Diseases for Ischemic Colitis

Diseases related to Ischemic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 arteriovenous fistula 30.2 APOH MMP2
2 arteriovenous malformation 30.1 MMP9 VEGFA
3 thrombosis 29.8 APOH F2 F5 SERPINC1 SERPINE1
4 acute myocardial infarction 29.7 MMP9 SERPINC1 SERPINE1
5 antiphospholipid syndrome 29.7 APOH F2 F5 SERPINC1
6 purpura 29.6 APOH F2 SERPINC1
7 coronary artery anomaly 29.6 F2 F5 SERPINE1
8 budd-chiari syndrome 29.4 APOH F2 F5 SERPINC1
9 transverse myelitis 29.4 APOH MMP2 MMP9
10 disseminated intravascular coagulation 29.4 F2 F5 SERPINC1 SERPINE1
11 thrombophilia due to thrombin defect 29.4 APOH F2 F5 SERPINC1 SERPINE1
12 portal vein thrombosis 29.2 APOH F2 F5 SERPINC1 SERPINE1
13 pulmonary embolism 29.2 APOH F2 F5 SERPINC1 SERPINE1
14 arteries, anomalies of 29.0 MMP9 SERPINC1 SERPINE1 VEGFA
15 myocardial infarction 28.7 F2 F5 MMP2 MMP9 SERPINC1 SERPINE1
16 colitis 11.1
17 systemic lupus erythematosus 10.2
18 lupus erythematosus 10.2
19 arteritic anterior ischemic optic neuropathy 10.2 F2 F5
20 paracetamol poisoning 10.2 F2 F5
21 hemoglobin e disease 10.2 F2 F5
22 may-thurner syndrome 10.2 APOH F5
23 leech infestation 10.2 F2 SERPINC1
24 intestinal impaction 10.2 F2 SERPINC1
25 fournier gangrene 10.2 F2 SERPINC1
26 acanthamoeba keratitis 10.2 APOH F5
27 hemorrhagic fever 10.2 F2 SERPINC1
28 alpha-2-plasmin inhibitor deficiency 10.2 F2 SERPINC1
29 intracranial embolism 10.2 F2 SERPINC1
30 factor viii deficiency 10.2 F2 F5
31 porencephaly 10.2 F2 F5
32 giant hemangioma 10.2 F2 SERPINC1
33 pregnancy loss, recurrent 1 10.2 APOH F5
34 gastroschisis 10.2 F2 F5
35 korean hemorrhagic fever 10.2 F2 SERPINC1
36 marantic endocarditis 10.2 F2 SERPINC1
37 purpura fulminans 10.2 F2 SERPINC1
38 esophageal varix 10.2 F2 SERPINC1
39 inferior vena cava interruption 10.2 F5 SERPINE1
40 adult respiratory distress syndrome 10.2 F2 SERPINE1
41 anterior spinal artery syndrome 10.2 F2 SERPINC1
42 hypersplenism 10.2 F2 SERPINC1
43 inherited blood coagulation disease 10.2 F2 SERPINC1
44 acute liver failure 10.1 F2 F5
45 fibrinolytic defect 10.1 SERPINC1 SERPINE1
46 carotid artery occlusion 10.1 APOH F5
47 factor xi deficiency 10.1 F2 SERPINC1
48 papilledema 10.1 APOH F2
49 aortic aneurysm 10.1
50 aspirin allergy 10.1 SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Ischemic Colitis:



Diseases related to Ischemic Colitis

Symptoms & Phenotypes for Ischemic Colitis

MGI Mouse Phenotypes related to Ischemic Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 F2 F5 MMP2 MMP9 SERPINC1 SERPINE1
2 homeostasis/metabolism MP:0005376 9.86 APOH F2 F5 MMP2 MMP9 SERPINC1
3 hematopoietic system MP:0005397 9.8 F2 MMP2 MMP9 SERPINC1 SERPINE1 VEGFA
4 mortality/aging MP:0010768 9.56 APOH F2 F5 MMP2 MMP9 SERPINC1
5 integument MP:0010771 9.55 F2 F5 MMP9 SERPINE1 VEGFA
6 respiratory system MP:0005388 9.02 F2 MMP2 MMP9 SERPINE1 VEGFA

Drugs & Therapeutics for Ischemic Colitis

Drugs for Ischemic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Coal tar Approved 8007-45-2
2 Anesthetics Not Applicable
3 Cola
4 Blood Substitutes Not Applicable
5 tyrosine Not Applicable
6 Anticoagulants Not Applicable
7 Angiogenesis Inhibitors Not Applicable
8 Plasma Substitutes Not Applicable
9 Dextrans Not Applicable
10 Anti-Bacterial Agents
11 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preconditioning Shields Against Vascular Events in Surgery Unknown status NCT02097186 Not Applicable
2 Study of Ischemic Colitis Compared to Other Diagnoses in Patients With Lower Gastrointestinal Bleeding Completed NCT01078324
3 Preconditioning Shields Against Vascular Events in Surgery Completed NCT01691911 Not Applicable
4 Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery Completed NCT01404910 Not Applicable
5 Determination of the Aetiologies of Acute Colitis and Early Identification of Patients Requiring Diagnostic Colonoscopy Recruiting NCT02709213
6 Iliac Branch Device Movement During Cardiac Cycle (IBD-dynamics) Recruiting NCT03762525 Not Applicable
7 Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy Not yet recruiting NCT03450512
8 Study to Explore Morbimortality in Patients Dialyzed With the Theranova HDx in Comparison to On-Line-Hemodiafiltration Not yet recruiting NCT03714386 Not Applicable

Search NIH Clinical Center for Ischemic Colitis

Cochrane evidence based reviews: colitis, ischemic

Genetic Tests for Ischemic Colitis

Anatomical Context for Ischemic Colitis

MalaCards organs/tissues related to Ischemic Colitis:

41
Colon, Myeloid, Liver, Lung, Heart, Spinal Cord, Placenta

Publications for Ischemic Colitis

Articles related to Ischemic Colitis:

(show top 50) (show all 575)
# Title Authors Year
1
Ischemic Colitis in Sickle Cell Disease: A Case Report of a Diagnostic Challenge. ( 29623225 )
2018
2
Ischemic colitis following left antegrade sclerotherapy for idiopathic varicocele. ( 29473213 )
2018
3
Gas In The Hepatic Portal Venous System Associated With Ischemic Colitis. ( 29880969 )
2018
4
Magnesium poisoning, multi-organ failure and ischemic colitis secondary to chronic ingestion of a parapharmacy product. ( 29667416 )
2018
5
Thumbprinting in Ischemic Colitis. ( 29897854 )
2018
6
Endovascular Treatment of an Inferior Mesenteric Arteriovenous Malformation Causing Ischemic Colitis. ( 30368321 )
2018
7
Repeat Ischemic Colitis in a Patient Taking Quetiapine. ( 30476377 )
2018
8
One Oral Dose of Sodium Polystyrene Sulfonate Associated with Ischemic Colitis and Crystal Deposition in Colonic Mucosa. ( 30370313 )
2018
9
Atypical cause of intractable diarrhea in a hemodialysis patient, masked by Clostridium difficile-associated diarrhea and ischemic colitis: a case report. ( 30384836 )
2018
10
Ischemic colitis caused by polycythemia vera: A case report and literature review. ( 30233723 )
2018
11
Successful Laparoscopy-Assisted Resection of the Descending Colon in a Patient with Multiple Large Renal Cysts and Stricture of the Colon due to Ischemic Colitis. ( 30283290 )
2018
12
Therapeutic effects of Ginkgo biloba extract against acute ischemic colitis. ( 30170462 )
2018
13
Ischemic colitis after translumbar n-butyl cyanoacrylate injection for treatment of endoleak. ( 30175300 )
2018
14
A Case-control Study on the Risk Factors for Ischemic Colitis. ( 30191546 )
2018
15
Ischemic colitis caused increased early and delayed mortality. ( 30008799 )
2018
16
Gastrointestinal: "Ghost gland" in probe-based confocal laser endomicroscopy for diagnosing ischemic colitis: A novel approach. ( 30022516 )
2018
17
Pseudoephedrine Induced Ischemic Colitis: A Case Report and Review of Literature. ( 30050703 )
2018
18
'Runs' from a run: A case of exercise induced ischemic colitis. ( 29123610 )
2017
19
Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center. ( 28769977 )
2017
20
The incidence and outcome of ischemic colitis in a population-based setting. ( 28276832 )
2017
21
Association between lower air pressure and the onset of ischemic colitis: a case-control study. ( 28562393 )
2017
22
Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination. ( 28878651 )
2017
23
Severe Cytomegalovirus Infection Masquerading as Recurrent Ischemic Colitis in a Patient with End-Stage Renal Disease. ( 29299486 )
2017
24
The Incidence of Ischemic Colitis after Repair of Ruptured Abdominal Aortic Aneurysms is Decreasing in the Endovascular Era. ( 28919522 )
2017
25
Pemetrexed-associated Ischemic Colitis in Nonsmall Cell Lung Cancer. ( 28685736 )
2017
26
Fulminant gangrenous ischemic colitis: is it the solely severe type of ischemic colitis? ( 27838817 )
2017
27
Predictors of severity in ischemic colitis: Usefulness of early ultrasonography. ( 29103470 )
2017
28
Idiopathic Myointimal Hyperplasia of Mesenteric Veins: An Uncommon Cause of Ischemic Colitis With Distinct Mucosal Features. ( 28817406 )
2017
29
Cytomegalovirus: associated ischemic colitis in an immunocompetent patient. ( 28747055 )
2017
30
18F-FDG Uptake in Ischemic Colitis During Follow-up of a Patient With Lung Cancer. ( 28632689 )
2017
31
Predictive factors of mortality after colectomy in ischemic colitis: an ACS-NSQIP database study. ( 29766117 )
2017
32
Advents in the Diagnosis and Management of Ischemic Colitis. ( 28929100 )
2017
33
Pseudoephedrine Associated Ischemic Colitis. ( 28786857 )
2017
34
Ischemic colitis of the colon in streptozotocin-induced diabetic rats. ( 28780750 )
2017
35
Seasonal variation in occurrence of ischemic colitis: a retrospective study. ( 28222619 )
2017
36
Identification of the distinguishing features of Crohn's disease and ischemic colitis using computed tomographic enterography. ( 28852526 )
2017
37
Gastrointestinal: Phlebosclerotic colitis: A rare but increasingly recognized cause of ischemic colitis with telltale imaging features. ( 29024011 )
2017
38
Tubercular colitis masquerading as ischemic colitis: An unusual presentation. ( 29171457 )
2017
39
Stercoral colitis complicated with ischemic colitis: a double-edge sword. ( 29179680 )
2017
40
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. ( 26943694 )
2016
41
Ischemic colitis associated with acute carbon monoxide poisoning--a case report. ( 27265995 )
2016
42
Beyond Low Flow: How I Manage Ischemic Colitis. ( 27725651 )
2016
43
Anorexia nervosa hyperactivity-induced ischemic colitis (ANHIC): a new cause of anaemia. ( 27314583 )
2016
44
Severe ischemic colitis following olanzapine use - A case report. ( 26786111 )
2016
45
Ischemic Colitis as a Complication of Medication Use: An Analysis of the Federal Adverse Event Reporting System. ( 27073073 )
2016
46
Ischemic colitis following uncomplicated colonoscopy. ( 26751116 )
2016
47
Update on ischemic colitis: from etiopathology to treatment including patients of intensive care unit. ( 27152750 )
2016
48
A Rare Cause of Ischemic Colitis. ( 26972985 )
2016
49
Isolated naratriptan-associated ischemic colitis. ( 27695179 )
2016
50
Ischemic colitis as pseudocarcinoma: An unusual presentation. ( 27993411 )
2016

Variations for Ischemic Colitis

Expression for Ischemic Colitis

Search GEO for disease gene expression data for Ischemic Colitis.

Pathways for Ischemic Colitis

Pathways related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 F2 MMP2 MMP9 SERPINE1 VEGFA
2
Show member pathways
12.71 APOH F2 F5 SERPINC1 SERPINE1 VEGFA
3
Show member pathways
12.53 F2 F5 MMP9 SERPINC1
4 12.06 MMP2 MMP9 VEGFA
5 11.92 MMP2 MMP9 VEGFA
6 11.81 MMP2 MMP9 VEGFA
7
Show member pathways
11.75 F2 MMP2 MMP9
8 11.72 MMP2 MMP9 SERPINE1
9 11.67 MMP2 MMP9 VEGFA
10 11.58 MMP2 SERPINE1 VEGFA
11
Show member pathways
11.46 F2 F5 SERPINC1 SERPINE1
12 11.41 MMP2 MMP9 VEGFA
13 11.32 MMP2 MMP9
14
Show member pathways
11.3 MMP2 MMP9 VEGFA
15
Show member pathways
11.29 MMP2 MMP9
16 11.22 MMP2 MMP9 SERPINE1
17 11.2 SERPINE1 VEGFA
18 11.15 SERPINE1 VEGFA
19 11.15 MMP2 MMP9
20 11.12 MMP2 MMP9
21 11.1 F2 MMP9
22 11.07 F2 F5 SERPINC1 SERPINE1
23 11.01 SERPINC1 VEGFA
24 11.01 MMP2 MMP9
25 10.98 F2 MMP9
26 10.95 MMP9 VEGFA
27 10.91 MMP2 MMP9
28 10.86 F2 MMP2

GO Terms for Ischemic Colitis

Cellular components related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 APOH F2 F5 MMP2 MMP9 SERPINC1
2 collagen-containing extracellular matrix GO:0062023 9.55 APOH MMP2 MMP9 SERPINC1 SERPINE1
3 extracellular matrix GO:0031012 9.54 MMP2 MMP9 VEGFA
4 endoplasmic reticulum lumen GO:0005788 9.5 F2 F5 SERPINC1
5 platelet alpha granule lumen GO:0031093 9.43 F5 SERPINE1 VEGFA
6 extracellular space GO:0005615 9.23 APOH F2 F5 MMP2 MMP9 SERPINC1

Biological processes related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.74 MMP2 MMP9 VEGFA
2 angiogenesis GO:0001525 9.71 MMP2 SERPINE1 VEGFA
3 blood coagulation GO:0007596 9.69 F2 F5 SERPINC1
4 positive regulation of protein phosphorylation GO:0001934 9.65 F2 MMP9 VEGFA
5 cellular protein metabolic process GO:0044267 9.62 F2 F5 MMP2 SERPINC1
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.58 MMP2 MMP9
7 lactation GO:0007595 9.58 SERPINC1 VEGFA
8 embryo implantation GO:0007566 9.56 MMP2 MMP9
9 platelet degranulation GO:0002576 9.56 APOH F5 SERPINE1 VEGFA
10 collagen catabolic process GO:0030574 9.55 MMP2 MMP9
11 hemostasis GO:0007599 9.54 F2 F5 SERPINC1
12 endodermal cell differentiation GO:0035987 9.52 MMP2 MMP9
13 fibrinolysis GO:0042730 9.49 F2 SERPINE1
14 blood coagulation, intrinsic pathway GO:0007597 9.46 APOH F2
15 macrophage differentiation GO:0030225 9.43 MMP9 VEGFA
16 negative regulation of blood coagulation GO:0030195 9.4 APOH SERPINE1
17 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
18 regulation of blood coagulation GO:0030193 9.13 APOH F2 SERPINC1
19 negative regulation of fibrinolysis GO:0051918 8.8 APOH F2 SERPINE1

Molecular functions related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 MMP2 MMP9
2 heparin binding GO:0008201 8.92 APOH F2 SERPINC1 VEGFA

Sources for Ischemic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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