MCID: ISC015
MIFTS: 46

Ischemic Colitis

Categories: Blood diseases, Gastrointestinal diseases

Aliases & Classifications for Ischemic Colitis

MalaCards integrated aliases for Ischemic Colitis:

Name: Ischemic Colitis 12 15
Colitis, Ischemic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060181
MeSH 45 D017091
SNOMED-CT 69 30588004
ICD10 34 K55.9
UMLS 74 C0162529

Summaries for Ischemic Colitis

Disease Ontology : 12 A colitis caused_by inadequate blood supply to the colon.

MalaCards based summary : Ischemic Colitis, also known as colitis, ischemic, is related to arteriovenous fistula and antiphospholipid syndrome. An important gene associated with Ischemic Colitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Coal tar and Tyrosine have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and... more...

Related Diseases for Ischemic Colitis

Diseases related to Ischemic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 arteriovenous fistula 30.0 APOH HMOX1
2 antiphospholipid syndrome 29.7 APOH F2 F5 SERPINC1
3 purpura 29.6 APOH F2 SERPINC1
4 acute myocardial infarction 29.6 ACE SERPINC1 SERPINE1
5 thrombosis 29.6 APOH F2 F5 SERPINC1 SERPINE1
6 arteries, anomalies of 29.4 ACE SERPINC1 SERPINE1
7 budd-chiari syndrome 29.4 APOH F2 F5 SERPINC1
8 disseminated intravascular coagulation 29.3 F2 F5 SERPINC1 SERPINE1
9 thrombophilia due to thrombin defect 29.1 APOH F2 F5 SERPINC1 SERPINE1
10 coronary artery anomaly 29.1 ACE F2 F5 SERPINE1
11 ischemia 28.9 ACE HIF1A HMOX1
12 portal vein thrombosis 28.9 APOH F2 F5 SERPINC1 SERPINE1
13 pulmonary embolism 28.9 APOH F2 F5 SERPINC1 SERPINE1
14 myocardial infarction 28.7 ACE F2 F5 HIF1A SERPINC1 SERPINE1
15 colitis 11.1
16 paracetamol poisoning 10.3 F2 F5
17 may-thurner syndrome 10.3 APOH F5
18 hemoglobin e disease 10.3 F2 F5
19 leech infestation 10.3 F2 SERPINC1
20 intestinal impaction 10.3 F2 SERPINC1
21 fournier gangrene 10.3 F2 SERPINC1
22 acanthamoeba keratitis 10.3 APOH F5
23 factor viii deficiency 10.3 F2 F5
24 porencephaly 10.3 F2 F5
25 alpha-2-plasmin inhibitor deficiency 10.3 F2 SERPINC1
26 intracranial embolism 10.3 F2 SERPINC1
27 pregnancy loss, recurrent 1 10.2 APOH F5
28 giant hemangioma 10.2 F2 SERPINC1
29 systemic lupus erythematosus 10.2
30 lupus erythematosus 10.2
31 korean hemorrhagic fever 10.2 F2 SERPINC1
32 marantic endocarditis 10.2 F2 SERPINC1
33 purpura fulminans 10.2 F2 SERPINC1
34 esophageal varix 10.2 F2 SERPINC1
35 anterior spinal artery syndrome 10.2 F2 SERPINC1
36 inferior vena cava interruption 10.2 F5 SERPINE1
37 amaurosis fugax 10.2 F5 SERPINE1
38 hypersplenism 10.2 F2 SERPINC1
39 aortic aneurysm 10.2
40 inherited blood coagulation disease 10.2 F2 SERPINC1
41 fibrinolytic defect 10.2 SERPINC1 SERPINE1
42 carotid artery occlusion 10.2 APOH F5
43 acute liver failure 10.2 F2 F5
44 factor xi deficiency 10.2 F2 SERPINC1
45 aspirin allergy 10.2 SERPINC1 SERPINE1
46 papilledema 10.2 APOH F2
47 argentine hemorrhagic fever 10.2 SERPINC1 SERPINE1
48 aortic aneurysm, familial abdominal, 1 10.2
49 thrombasthenia 10.2 F2 F5
50 quebec platelet disorder 10.2 F5 SERPINE1

Graphical network of the top 20 diseases related to Ischemic Colitis:



Diseases related to Ischemic Colitis

Symptoms & Phenotypes for Ischemic Colitis

GenomeRNAi Phenotypes related to Ischemic Colitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 ACE APOH F2 HIF1A HMOX1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 ACE APOH F2 HIF1A HMOX1

MGI Mouse Phenotypes related to Ischemic Colitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 ACE F2 F5 HIF1A HMOX1 SERPINC1
2 homeostasis/metabolism MP:0005376 9.92 ACE APOH F2 F5 HIF1A HMOX1
3 hematopoietic system MP:0005397 9.85 ACE F2 HIF1A HMOX1 SERPINC1 SERPINE1
4 immune system MP:0005387 9.73 ACE F2 HIF1A HMOX1 SERPINC1 SERPINE1
5 liver/biliary system MP:0005370 9.63 ACE F5 HIF1A HMOX1 SERPINC1 SERPINE1
6 mortality/aging MP:0010768 9.56 ACE APOH F2 F5 HIF1A HMOX1
7 renal/urinary system MP:0005367 9.02 ACE HIF1A HMOX1 SERPINC1 SERPINE1

Drugs & Therapeutics for Ischemic Colitis

Drugs for Ischemic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Coal tar Approved 8007-45-2
2
Tyrosine Approved, Investigational, Nutraceutical Not Applicable 60-18-4 6057
3 Anesthetics Not Applicable
4 Cola
5 Anticoagulants Not Applicable
6 Plasma Substitutes Not Applicable
7 Dextrans Not Applicable
8 Blood Substitutes Not Applicable
9 Angiogenesis Inhibitors Not Applicable
10 Anti-Bacterial Agents
11 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preconditioning Shields Against Vascular Events in Surgery Unknown status NCT02097186 Not Applicable
2 Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum Unknown status NCT00534131 Not Applicable
3 Study of Ischemic Colitis Compared to Other Diagnoses in Patients With Lower Gastrointestinal Bleeding Completed NCT01078324
4 Preconditioning Shields Against Vascular Events in Surgery Completed NCT01691911 Not Applicable
5 Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery Completed NCT01404910 Not Applicable
6 Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy Recruiting NCT03450512
7 Determination of the Aetiologies of Acute Colitis and Early Identification of Patients Requiring Diagnostic Colonoscopy Recruiting NCT02709213
8 Iliac Branch Device Movement During Cardiac Cycle (IBD-dynamics) Recruiting NCT03762525 Not Applicable
9 Study to Explore Morbimortality in Patients Dialyzed With the Theranova HDx in Comparison to On-Line-Hemodiafiltration Not yet recruiting NCT03714386 Not Applicable

Search NIH Clinical Center for Ischemic Colitis

Cochrane evidence based reviews: colitis, ischemic

Genetic Tests for Ischemic Colitis

Anatomical Context for Ischemic Colitis

MalaCards organs/tissues related to Ischemic Colitis:

42
Colon, Heart, Liver, Lung, Bone, Myeloid, Bone Marrow

Publications for Ischemic Colitis

Articles related to Ischemic Colitis:

(show top 50) (show all 582)
# Title Authors Year
1
Mass-Forming Ischemic Colitis: A Potential Mimicker of Malignancy. ( 31007961 )
2019
2
Ischemic Colitis Secondary to Dextromethorphan Overdose. ( 31033494 )
2019
3
Ischemic Colitis. ( 30850260 )
2019
4
Ischemic colitis due to antiphospholipid antibody syndrome. ( 30793065 )
2019
5
Ischemic colitis associated with intravitreal administration of aflibercept: a first case report. ( 30610744 )
2019
6
Inferior mesenteric artery replantation does not decrease the risk of ischemic colitis after open infrarenal abdominal aortic aneurysm repair. ( 30591291 )
2018
7
Ischemic colitis following infrarenal abdominal aortic aneurysm treatment: Results from a tertiary medical center. ( 30688933 )
2018
8
Endovascular Treatment of an Inferior Mesenteric Arteriovenous Malformation Causing Ischemic Colitis. ( 30368321 )
2018
9
Repeat Ischemic Colitis in a Patient Taking Quetiapine. ( 30476377 )
2018
10
One Oral Dose of Sodium Polystyrene Sulfonate Associated with Ischemic Colitis and Crystal Deposition in Colonic Mucosa. ( 30370313 )
2018
11
Atypical cause of intractable diarrhea in a hemodialysis patient, masked by Clostridium difficile-associated diarrhea and ischemic colitis: a case report. ( 30384836 )
2018
12
Ischemic colitis caused by polycythemia vera: A case report and literature review. ( 30233723 )
2018
13
Successful Laparoscopy-Assisted Resection of the Descending Colon in a Patient with Multiple Large Renal Cysts and Stricture of the Colon due to Ischemic Colitis. ( 30283290 )
2018
14
Therapeutic effects of Ginkgo biloba extract against acute ischemic colitis. ( 30170462 )
2018
15
Ischemic colitis after translumbar n-butyl cyanoacrylate injection for treatment of endoleak. ( 30175300 )
2018
16
A Case-control Study on the Risk Factors for Ischemic Colitis. ( 30191546 )
2018
17
Ischemic colitis caused increased early and delayed mortality. ( 30008799 )
2018
18
Gastrointestinal: "Ghost gland" in probe-based confocal laser endomicroscopy for diagnosing ischemic colitis: A novel approach. ( 30022516 )
2018
19
Pseudoephedrine Induced Ischemic Colitis: A Case Report and Review of Literature. ( 30050703 )
2018
20
Thumbprinting in Ischemic Colitis. ( 29897854 )
2018
21
Gas In The Hepatic Portal Venous System Associated With Ischemic Colitis. ( 29880969 )
2018
22
Ischemic Colitis in Sickle Cell Disease: A Case Report of a Diagnostic Challenge. ( 29623225 )
2018
23
Magnesium poisoning, multi-organ failure and ischemic colitis secondary to chronic ingestion of a parapharmacy product. ( 29667416 )
2018
24
Ischemic colitis following left antegrade sclerotherapy for idiopathic varicocele. ( 29473213 )
2018
25
The Incidence of Ischemic Colitis after Repair of Ruptured Abdominal Aortic Aneurysms Is Decreasing in the Endovascular Era. ( 28919522 )
2018
26
Ischemic colitis of the colon in streptozotocin-induced diabetic rats. ( 28780750 )
2018
27
Pseudoephedrine Associated Ischemic Colitis. ( 28786857 )
2018
28
Predictive factors of mortality after colectomy in ischemic colitis: an ACS-NSQIP database study. ( 29766117 )
2017
29
Severe Cytomegalovirus Infection Masquerading as Recurrent Ischemic Colitis in a Patient with End-Stage Renal Disease. ( 29299486 )
2017
30
Tubercular colitis masquerading as ischemic colitis: An unusual presentation. ( 29171457 )
2017
31
Stercoral colitis complicated with ischemic colitis: a double-edge sword. ( 29179680 )
2017
32
Predictors of severity in ischemic colitis: Usefulness of early ultrasonography. ( 29103470 )
2017
33
'Runs' from a run: A case of exercise induced ischemic colitis. ( 29123610 )
2017
34
Advents in the Diagnosis and Management of Ischemic Colitis. ( 28929100 )
2017
35
Gastrointestinal: Phlebosclerotic colitis: A rare but increasingly recognized cause of ischemic colitis with telltale imaging features. ( 29024011 )
2017
36
Identification of the distinguishing features of Crohn's disease and ischemic colitis using computed tomographic enterography. ( 28852526 )
2017
37
Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination. ( 28878651 )
2017
38
Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center. ( 28769977 )
2017
39
Idiopathic Myointimal Hyperplasia of Mesenteric Veins: An Uncommon Cause of Ischemic Colitis With Distinct Mucosal Features. ( 28817406 )
2017
40
Pemetrexed-associated Ischemic Colitis in Nonsmall Cell Lung Cancer. ( 28685736 )
2017
41
Cytomegalovirus: associated ischemic colitis in an immunocompetent patient. ( 28747055 )
2017
42
18F-FDG Uptake in Ischemic Colitis During Follow-up of a Patient With Lung Cancer. ( 28632689 )
2017
43
Association between lower air pressure and the onset of ischemic colitis: a case-control study. ( 28562393 )
2017
44
Fulminant gangrenous ischemic colitis: is it the solely severe type of ischemic colitis? ( 27838817 )
2017
45
Ischemic colitis as pseudocarcinoma: An unusual presentation. ( 27993411 )
2017
46
Serum procalcitonin correlates with colonoscopy findings and can guide therapeutic decisions in postoperative ischemic colitis. ( 28089622 )
2017
47
Seasonal variation in occurrence of ischemic colitis: a retrospective study. ( 28222619 )
2017
48
The incidence and outcome of ischemic colitis in a population-based setting. ( 28276832 )
2017
49
Anorexia nervosa hyperactivity-induced ischemic colitis (ANHIC): a new cause of anaemia. ( 27314583 )
2016
50
Risk factors and outcomes of postoperative ischemic colitis in contemporary open and endovascular abdominal aortic aneurysm repair. ( 26747680 )
2016

Variations for Ischemic Colitis

Expression for Ischemic Colitis

Search GEO for disease gene expression data for Ischemic Colitis.

Pathways for Ischemic Colitis

GO Terms for Ischemic Colitis

Cellular components related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 F2 F5 SERPINC1
2 extracellular region GO:0005576 9.43 ACE APOH F2 F5 SERPINC1 SERPINE1
3 collagen-containing extracellular matrix GO:0062023 9.33 APOH SERPINC1 SERPINE1
4 extracellular space GO:0005615 9.17 ACE APOH F2 F5 HMOX1 SERPINC1

Biological processes related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.74 F5 HIF1A SERPINC1
2 angiogenesis GO:0001525 9.71 HIF1A HMOX1 SERPINE1
3 cellular protein metabolic process GO:0044267 9.69 F2 F5 SERPINC1
4 blood coagulation GO:0007596 9.67 F2 F5 SERPINC1
5 positive regulation of angiogenesis GO:0045766 9.61 HIF1A HMOX1 SERPINE1
6 regulation of blood pressure GO:0008217 9.58 ACE HMOX1
7 cellular iron ion homeostasis GO:0006879 9.58 HIF1A HMOX1
8 lactation GO:0007595 9.56 HIF1A SERPINC1
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.55 HMOX1 SERPINE1
10 platelet degranulation GO:0002576 9.54 APOH F5 SERPINE1
11 positive regulation of macroautophagy GO:0016239 9.52 HIF1A HMOX1
12 fibrinolysis GO:0042730 9.48 F2 SERPINE1
13 blood coagulation, intrinsic pathway GO:0007597 9.46 APOH F2
14 hemostasis GO:0007599 9.43 F2 F5 SERPINC1
15 negative regulation of blood coagulation GO:0030195 9.4 APOH SERPINE1
16 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
17 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.32 HIF1A HMOX1
18 regulation of blood coagulation GO:0030193 9.13 APOH F2 SERPINC1
19 negative regulation of fibrinolysis GO:0051918 8.8 APOH F2 SERPINE1

Molecular functions related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Ischemic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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