MCID: ISC015
MIFTS: 43

Ischemic Colitis

Categories: Blood diseases, Gastrointestinal diseases

Aliases & Classifications for Ischemic Colitis

MalaCards integrated aliases for Ischemic Colitis:

Name: Ischemic Colitis 12 15
Colitis, Ischemic 44 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0060181
MeSH 44 D017091
SNOMED-CT 68 30588004
ICD10 33 K55.9
UMLS 72 C0162529

Summaries for Ischemic Colitis

Disease Ontology : 12 A colitis caused by inadequate blood supply to the colon.

MalaCards based summary : Ischemic Colitis, also known as colitis, ischemic, is related to factor viii deficiency and esophageal varix. An important gene associated with Ischemic Colitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and p70S6K Signaling. The drugs Analgesics and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and myeloid, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 75 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and... more...

Related Diseases for Ischemic Colitis

Diseases related to Ischemic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 349)
# Related Disease Score Top Affiliating Genes
1 factor viii deficiency 30.3 F5 F2
2 esophageal varix 30.3 SERPINC1 F2
3 hepatic veno-occlusive disease 30.0 SERPINE1 SERPINC1
4 venous insufficiency 29.9 SERPINE1 F2
5 antiphospholipid syndrome 29.9 SERPINC1 F5 F2 APOH
6 acute myocardial infarction 29.9 SERPINE1 SERPINC1 ACE
7 purpura 29.8 SERPINC1 F2 APOH
8 protein s deficiency 29.8 SERPINC1 F5 F2 APOH
9 polycythemia 29.7 JAK2 HIF1A F5
10 arteries, anomalies of 29.5 SERPINE1 SERPINC1 ACE
11 peripheral vascular disease 29.5 SERPINE1 SERPINC1 F2 ACE
12 prothrombin deficiency, congenital 29.4 SERPINC1 F5 F2 APOH
13 antithrombin iii deficiency 29.4 SERPINC1 F5 F2 APOH
14 heart valve disease 29.4 APOH ACE
15 arteriosclerosis 29.4 SERPINE1 HMOX1 ACE
16 disseminated intravascular coagulation 29.4 SERPINE1 SERPINC1 F5 F2
17 thrombophilia due to thrombin defect 29.3 SERPINE1 SERPINC1 F5 F2 APOH
18 thrombophilia 29.2 SERPINE1 SERPINC1 F5 F2 APOH
19 varicose veins 29.1 SERPINC1 HIF1A F5 F2
20 coronary artery anomaly 29.1 SERPINE1 F5 F2 ACE
21 thrombophilia due to activated protein c resistance 29.0 SERPINE1 SERPINC1 F5 F2 APOH
22 ischemia 29.0 HMOX1 HIF1A ACE
23 thrombophlebitis 28.8 SERPINE1 SERPINC1 F5 F2 APOH
24 pulmonary embolism 28.8 SERPINE1 SERPINC1 F5 F2 APOH
25 budd-chiari syndrome 28.7 SERPINC1 JAK2 F5 F2 APOH
26 thrombosis 28.6 SERPINE1 SERPINC1 JAK2 F5 F2 APOH
27 myocardial infarction 28.1 SERPINE1 SERPINC1 HIF1A F5 F2 ACE
28 portal vein thrombosis 28.1 SERPINE1 SERPINC1 JAK2 F5 F2 APOH
29 vascular disease 27.7 SERPINE1 SERPINC1 HMOX1 F5 F2 APOH
30 pre-eclampsia 26.8 SERPINE1 SERPINC1 HMOX1 HIF1A F5 F2
31 colitis 11.2
32 diarrhea 10.6
33 paracetamol poisoning 10.5 F5 F2
34 may-thurner syndrome 10.5 F5 APOH
35 hemoglobin e disease 10.5 F5 F2
36 fournier gangrene 10.5 SERPINC1 F2
37 acanthamoeba keratitis 10.5 F5 APOH
38 intestinal impaction 10.5 SERPINC1 F2
39 leech infestation 10.5 SERPINC1 F2
40 porencephaly 10.5 F5 F2
41 giant hemangioma 10.5 SERPINC1 F2
42 intracranial embolism 10.5 SERPINC1 F2
43 pregnancy loss, recurrent 1 10.5 F5 APOH
44 alpha-2-plasmin inhibitor deficiency 10.5 SERPINC1 F2
45 constipation 10.4
46 aortic aneurysm 10.4
47 marantic endocarditis 10.4 SERPINC1 F2
48 amaurosis fugax 10.4 SERPINE1 F5
49 korean hemorrhagic fever 10.4 SERPINC1 F2
50 purpura fulminans 10.4 SERPINC1 F2

Graphical network of the top 20 diseases related to Ischemic Colitis:



Diseases related to Ischemic Colitis

Symptoms & Phenotypes for Ischemic Colitis

GenomeRNAi Phenotypes related to Ischemic Colitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 ACE APOH F2 HIF1A HMOX1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 ACE APOH F2 HIF1A HMOX1

MGI Mouse Phenotypes related to Ischemic Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 ACE F2 F5 HIF1A HMOX1 SERPINC1
2 homeostasis/metabolism MP:0005376 9.97 ACE APOH F2 F5 HIF1A HMOX1
3 growth/size/body region MP:0005378 9.95 ACE F2 F5 HIF1A HMOX1 JAK2
4 hematopoietic system MP:0005397 9.91 ACE F2 HIF1A HMOX1 JAK2 SERPINC1
5 immune system MP:0005387 9.8 ACE F2 HIF1A HMOX1 JAK2 SERPINC1
6 liver/biliary system MP:0005370 9.7 ACE F5 HIF1A HMOX1 JAK2 SERPINC1
7 mortality/aging MP:0010768 9.61 ACE APOH F2 F5 HIF1A HMOX1
8 renal/urinary system MP:0005367 9.02 ACE HIF1A HMOX1 SERPINC1 SERPINE1

Drugs & Therapeutics for Ischemic Colitis

Drugs for Ischemic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Analgesics Phase 2, Phase 3
2 Anti-Inflammatory Agents Phase 2, Phase 3
3 Mesalamine Phase 2, Phase 3 89-57-6
4 Analgesics, Non-Narcotic Phase 2, Phase 3
5 Peripheral Nervous System Agents Phase 2, Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
7 Antirheumatic Agents Phase 2, Phase 3
8
Coal tar Approved 8007-45-2
9 Cola
10 Anti-Bacterial Agents
11 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Mesalazine on Low Grade Mucosal Inflammation in Irritable Bowel Syndrome. A Pilot Double Blind Placebo Controlled Study. Completed NCT00774007 Phase 2, Phase 3 mesalazine;placebo
2 A Multicentre Trial of the Anterior Perineal PlanE for Ultra Low Anterior Resection of the Rectum (The APPEAR Technique) in the Prevention of Permanent Stoma in Benign and Malignant Disease Unknown status NCT00534131
3 Ischemic Colitis Is a Common Cause of Severe Hematochezia and Patient Outcomes Are Worse Than With Other Colonic Diagnoses Completed NCT01078324
4 Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy (DECLAM). Recruiting NCT03450512

Search NIH Clinical Center for Ischemic Colitis

Cochrane evidence based reviews: colitis, ischemic

Genetic Tests for Ischemic Colitis

Anatomical Context for Ischemic Colitis

MalaCards organs/tissues related to Ischemic Colitis:

41
Colon, Kidney, Myeloid, Liver, Lung, Testes, Bone

Publications for Ischemic Colitis

Articles related to Ischemic Colitis:

(show top 50) (show all 1466)
# Title Authors PMID Year
1
[Clinical analysis of peri-operative gastrointestinal complications after endovascular and open repair of abdominal aortic aneurysm]. 38
31422628 2019
2
Hypogastric artery coverage during endovascular aneurysm repair in octogenarian and younger patients. 38
30950984 2019
3
Clostridium difficile colitis: CT findings and differential diagnosis. 38
31302848 2019
4
Diverticular Disease in the Elderly. 38
31346801 2019
5
Acute ischemic colitis with hematochezia related to baloxavir marboxil treatment for influenza A. 38
31176533 2019
6
Stent-assisted balloon-induced intimal disruption and relamination of distal remaining aortic dissection after acute DeBakey type I repair. 38
30501951 2019
7
Inferior mesenteric artery replantation does not decrease the risk of ischemic colitis after open infrarenal abdominal aortic aneurysm repair. 38
30591291 2019
8
Assessing trends, morbidity, and mortality in ruptured abdominal aortic aneurysm repair with nine years of data from the National Surgical Quality Improvement Program. 38
31227411 2019
9
[Rectal Ulcer Developed in Systemic Lupus Erythematosus without Ischemic Colitis]. 38
31132828 2019
10
Ischemic Colitis. 38
30850260 2019
11
Ischemic Colitis in Association with Sevelamer Crystals. 38
31142966 2019
12
SEVERE ISCHEMIC COLITIS PROBABLY RELATED TO DICLOFENAC. 38
31145258 2019
13
Multiparametric ultrasound in the diagnosis and monitoring of ischemic colitis: description of a case of ischemic colitis of the right colon and revision of the literature. 38
31119715 2019
14
The Colonic Single Stripe Sign: A Case of Ischemic Colitis. 38
31281764 2019
15
Ischemic Colitis Secondary to Dextromethorphan Overdose. 38
31033494 2019
16
Bladder necrosis and perforation in end-stage renal disease and recurrent urinary tract infection: A rare medical emergency. 38
31334054 2019
17
Robotic-assisted laparoscopic repair of rectovesical fistula after Hartmann's reversal procedure. 38
30062640 2019
18
Ischemic colitis due to antiphospholipid antibody syndrome. 38
30793065 2019
19
Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency. 38
31080679 2019
20
Mass-Forming Ischemic Colitis: A Potential Mimicker of Malignancy. 38
31007961 2019
21
Self-administered alcohol enema causing chemical proctocolitis. 38
31354369 2019
22
Melanosis Coli: A Case of Mistaken Identity-A Case Report. 38
30624202 2019
23
The Effect of Surgical Training and Operative Approach on Outcomes in Acute Diverticulitis: Should Guidelines Be Revised? 38
30451762 2019
24
Repeat Ischemic Colitis in a Patient Taking Quetiapine. 38
30476377 2018
25
Atypical cause of intractable diarrhea in a hemodialysis patient, masked by Clostridium difficile-associated diarrhea and ischemic colitis: a case report. 38
30384836 2018
26
Endovascular Treatment of an Inferior Mesenteric Arteriovenous Malformation Causing Ischemic Colitis. 38
30368321 2018
27
Gastrointestinal: "Ghost gland" in probe-based confocal laser endomicroscopy for diagnosing ischemic colitis: A novel approach. 38
30022516 2018
28
Stent-assisted, balloon-induced intimal disruption and relamination of aortic dissection in patients with Marfan syndrome: Midterm outcomes and aortic remodeling. 38
29934004 2018
29
Ischemic colitis caused by polycythemia vera: A case report and literature review. 38
30233723 2018
30
Hypogastric Preservation Using Retrograde Endovascular Bypass. 38
29908227 2018
31
Non-operative management of isolated spontaneous superior mesenteric artery dissection. 38
30397433 2018
32
Recent advances in pharmacological research on the management of irritable bowel syndrome. 38
30132170 2018
33
A rare cause of acute abdomen: Isolated necrosis of the cecum. 38
30248286 2018
34
Ischemic colitis following infrarenal abdominal aortic aneurysm treatment: Results from a tertiary medical center. 38
30688933 2018
35
Pseudoephedrine Associated Ischemic Colitis. 38
28786857 2018
36
Gas In The Hepatic Portal Venous System Associated With Ischemic Colitis. 38
29880969 2018
37
A Case-control Study on the Risk Factors for Ischemic Colitis. 38
30191546 2018
38
Ischemic colitis after translumbar n-butyl cyanoacrylate injection for treatment of endoleak. 38
30175300 2018
39
Rectal ischemia causes mass formation, masquerading as rectal cancer. 38
30159159 2018
40
Ischemic colitis following left antegrade sclerotherapy for idiopathic varicocele. 38
29473213 2018
41
Therapeutic effects of Ginkgo biloba extract against acute ischemic colitis. 38
30170462 2018
42
Colitis with wall thickening and edematous changes during oral administration of the powdered form of Qing-dai in patients with ulcerative colitis: a report of two cases. 38
29549501 2018
43
Role of hemostatic powders in the management of lower gastrointestinal bleeding: A review. 38
29405446 2018
44
Severe ischemic cytomegalovirus proctocolitis with multiple perforation. 38
29532267 2018
45
Anti-Inflammatory Biologics and Anti-Tumoral Immune Therapies-Associated Colitis: A Focused Review of Literature. 38
29915627 2018
46
Thumbprinting in Ischemic Colitis. 38
29897854 2018
47
Magnesium poisoning, multi-organ failure and ischemic colitis secondary to chronic ingestion of a parapharmacy product. 38
29667416 2018
48
Globular amyloidosis of the colon. 38
29805093 2018
49
Partial Cecum Necrosis as a Rare Cause of Acute Abdominal Pain in an Elderly Patient. 38
29866228 2018
50
Cecum perforation induced by mycophenolate mofetil after hematopoietic stem cell transplantation: A case report and review of literature. 38
29923335 2018

Variations for Ischemic Colitis

Expression for Ischemic Colitis

Search GEO for disease gene expression data for Ischemic Colitis.

Pathways for Ischemic Colitis

Pathways related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 SERPINE1 SERPINC1 JAK2 F5 F2 APOH
2
Show member pathways
12.66 JAK2 HIF1A F2 ACE
3
Show member pathways
11.86 SERPINE1 JAK2 HIF1A
4 11.6 JAK2 HMOX1 HIF1A
5 11.54 SERPINE1 HMOX1 HIF1A
6
Show member pathways
11.46 SERPINE1 SERPINC1 F5 F2
7 11.25 SERPINE1 HMOX1 HIF1A
8 11.18 JAK2 HIF1A
9 11.07 SERPINE1 SERPINC1 F5 F2
10 11.02 SERPINE1 HIF1A
11
Show member pathways
10.88 JAK2 HIF1A

GO Terms for Ischemic Colitis

Cellular components related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 SERPINC1 F5 F2
2 extracellular region GO:0005576 9.43 SERPINE1 SERPINC1 F5 F2 APOH ACE
3 collagen-containing extracellular matrix GO:0062023 9.33 SERPINE1 SERPINC1 APOH
4 extracellular space GO:0005615 9.17 SERPINE1 SERPINC1 HMOX1 F5 F2 APOH

Biological processes related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 JAK2 HMOX1 HIF1A
2 angiogenesis GO:0001525 9.74 SERPINE1 HMOX1 HIF1A
3 cellular protein metabolic process GO:0044267 9.7 SERPINC1 F5 F2
4 positive regulation of angiogenesis GO:0045766 9.67 SERPINE1 HMOX1 HIF1A
5 negative regulation of neuron apoptotic process GO:0043524 9.63 JAK2 HMOX1 HIF1A
6 lactation GO:0007595 9.58 SERPINC1 HIF1A
7 platelet degranulation GO:0002576 9.58 SERPINE1 F5 APOH
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 SERPINE1 HMOX1
9 blood coagulation GO:0007596 9.56 SERPINC1 JAK2 F5 F2
10 negative regulation of DNA binding GO:0043392 9.55 JAK2 HMOX1
11 positive regulation of macroautophagy GO:0016239 9.54 HMOX1 HIF1A
12 fibrinolysis GO:0042730 9.51 SERPINE1 F2
13 hemostasis GO:0007599 9.5 SERPINC1 F5 F2
14 blood coagulation, intrinsic pathway GO:0007597 9.48 F2 APOH
15 negative regulation of blood coagulation GO:0030195 9.43 SERPINE1 APOH
16 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.37 HMOX1 HIF1A
17 regulation of blood coagulation GO:0030193 9.33 SERPINC1 F2 APOH
18 positive regulation of blood coagulation GO:0030194 9.13 SERPINE1 F2 APOH
19 negative regulation of fibrinolysis GO:0051918 8.8 SERPINE1 F2 APOH

Molecular functions related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 SERPINC1 F2 APOH

Sources for Ischemic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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