MCID: ISC015
MIFTS: 41

Ischemic Colitis

Categories: Blood diseases, Gastrointestinal diseases
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Aliases & Classifications for Ischemic Colitis

MalaCards integrated aliases for Ischemic Colitis:

Name: Ischemic Colitis 11 14 75
Colitis, Ischemic 43 71
Irreversible Ischaemic Colitis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:0060181
MeSH 43 D017091
SNOMED-CT 68 30588004
ICD10 31 K55.9
ICD11 33 53001072
UMLS 71 C0162529

Summaries for Ischemic Colitis

Disease Ontology: 11 A colitis caused by inadequate blood supply to the colon.

MalaCards based summary: Ischemic Colitis, also known as colitis, ischemic, is related to colitis and megacolon. An important gene associated with Ischemic Colitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Sudden infant death syndrome (SIDS) susceptibility pathways. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and kidney, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia: 75 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and... more...

Related Diseases for Ischemic Colitis

Diseases related to Ischemic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 988)
# Related Disease Score Top Affiliating Genes
1 colitis 31.9 TNF IL6 CRP CCR6
2 megacolon 30.8 CCR6 ATP4A ATP12A
3 ileus 30.6 TNF IL6 CRP
4 inflammatory bowel disease 1 30.6 TNF IL6 CCR6
5 clostridium difficile colitis 30.5 CRP CCR6 ATP4A ATP12A ALB
6 peritonitis 30.4 TNF IL6 F2 CRP ALB
7 ulcerative colitis 30.4 TNF IL6 CRP CCR6
8 amyloidosis 30.4 TNF IL6 CRP ALB
9 portal hypertension 30.4 TNF F2 CCR6 ALB
10 acute kidney failure 30.3 IL6 F2 ALB
11 polyarteritis nodosa 30.3 TNF IL6 CRP
12 arteriovenous malformation 30.3 F3 F2 ALB
13 takayasu arteritis 30.3 TNF IL6 CRP
14 collagenous colitis 30.3 TNF ATP4A ATP12A
15 proctitis 30.2 TNF CRP CCR6
16 buerger disease 30.2 SERPINC1 F2 CRP
17 aortic aneurysm, familial abdominal, 1 30.2 TNF IL6 F3 CRP CCR6 ALB
18 diarrhea 30.2 TPH1 TNF IL6 HTR3A ALB
19 crohn's disease 30.2 TNF IL6 CRP CCR6 ALB
20 congestive heart failure 30.1 TNF IL6 ALB ACE2
21 thrombophilia due to thrombin defect 30.1 SERPINC1 F3 F2
22 aortic aneurysm 30.1 TNF IL6 F3 F2 CRP ALB
23 human cytomegalovirus infection 30.1 TNF IL6 CCR6
24 cholecystitis 30.1 F2 CRP ALB
25 irritable bowel syndrome 30.1 TPH1 TNF IL6 HTR3A CRP
26 chronic kidney disease 30.1 TNF IL6 CRP CCR6 ALB
27 intestinal tuberculosis 30.0 TNF CRP ALB
28 toxic megacolon 30.0 TNF CRP CCR6 ATP4A ATP12A ALB
29 prothrombin deficiency, congenital 30.0 SERPINC1 F2
30 protein s deficiency 30.0 SERPINC1 F3 F2
31 reactive arthritis 30.0 TNF CRP CCR6
32 hernia, hiatus 30.0 CRP ATP4A ATP12A ALB
33 thyroiditis 29.9 TNF IL6 CRP
34 intussusception 29.9 IL6 CRP ALB
35 uremia 29.9 TNF IL6 CRP ALB
36 gastroenteritis 29.9 TNF IL6 CRP ALB
37 hemolytic-uremic syndrome 29.9 SERPINC1 F3 F2
38 systemic scleroderma 29.9 TNF IL6 CRP CCR6
39 thrombocytopenic purpura, autoimmune 29.9 F3 F2 CCR6
40 hemolytic uremic syndrome, atypical 1 29.9 F3 F2 CRP ALB
41 arteriosclerosis 29.9 SERPINC1 IL6 F3 CRP
42 acute asthma 29.9 TNF IL6 CCR6
43 thrombophilia due to activated protein c resistance 29.8 SERPINC1 F3 F2
44 brucellosis 29.8 TNF IL6 CRP
45 familial mediterranean fever 29.8 TNF IL6 CRP
46 toxic shock syndrome 29.8 TNF SERPINC1 IL6 F3 CRP
47 extrinsic allergic alveolitis 29.8 TNF IL6 CCR6
48 femoral neuropathy 29.8 F3 F2 CRP
49 varicocele 29.8 TNF IL6 ALB
50 enterocolitis 29.8 TNF IL6 FABP2 CRP

Graphical network of the top 20 diseases related to Ischemic Colitis:



Diseases related to Ischemic Colitis

Symptoms & Phenotypes for Ischemic Colitis

MGI Mouse Phenotypes related to Ischemic Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACADS ACE2 ALB ATP12A ATP4A CCR6
2 muscle MP:0005369 10.14 ACADS ACE2 ALB F2 F3 HTR2B
3 renal/urinary system MP:0005367 10.09 ACADS ACE2 ALB ATP12A FABP2 HTR3A
4 growth/size/body region MP:0005378 10.07 ACE2 ATP12A ATP4A F2 F3 FABP2
5 adipose tissue MP:0005375 9.91 F2 FABP2 HTR2B IL6 NPR3 TNF
6 endocrine/exocrine gland MP:0005379 9.81 ALB ATP4A F2 HTR2B HTR3A IL6
7 cardiovascular system MP:0005385 9.73 ACE2 ALB CCR6 CRP F2 F3
8 immune system MP:0005387 9.44 ACE2 ALB ATP4A CCR6 CRP F2

Drugs & Therapeutics for Ischemic Colitis

Drugs for Ischemic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicentre Trial of the Anterior Perineal PlanE for Ultra Low Anterior Resection of the Rectum (The APPEAR Technique) in the Prevention of Permanent Stoma in Benign and Malignant Disease Unknown status NCT00534131
2 Ischemic Colitis Is a Common Cause of Severe Hematochezia and Patient Outcomes Are Worse Than With Other Colonic Diagnoses Completed NCT01078324
3 Assessment of a Composite Prognostic Score to Predict Severe Forms of Ischemic Colitis of Montpellier Completed NCT04662268

Search NIH Clinical Center for Ischemic Colitis

Cochrane evidence based reviews: colitis, ischemic

Genetic Tests for Ischemic Colitis

Anatomical Context for Ischemic Colitis

Organs/tissues related to Ischemic Colitis:

MalaCards : Colon, Bone Marrow, Kidney, Liver, Salivary Gland, Smooth Muscle, Pancreas

Publications for Ischemic Colitis

Articles related to Ischemic Colitis:

(show top 50) (show all 1662)
# Title Authors PMID Year
1
Laparoscopic versus open emergent colectomy for ischemic colitis: a propensity score-matched comparison. 62
36229844 2022
2
Colonoscopy induced ischemic colitis: An endoscopic and histological assay. 62
35760321 2022
3
Development and validation of a composite score to predict severe forms of ischemic colitis. 62
35353197 2022
4
Sheng-Xue-Xiao-Ban Capsule-induced ischemic colitis and pulmonary embolism in an idiopathic thrombocytopenic purpura patient: a rare case report. 62
36267749 2022
5
Chinese dragon sign of ulcerative colitis. 62
36093970 2022
6
Non-perforated Stercoral Colitis patients with septic shock have a higher mortality than their perforated counterparts. A case report and review of literature. 62
36030766 2022
7
Solitary rectal ulcer syndrome in a young adult - A surgeon's dilemma with rectal carcinoma. 62
36093443 2022
8
Ischemic Colitis Presented as Pseudomembranous Colitis: An Untypical Case from Vietnam. 62
36004637 2022
9
Clinical characteristics and long-term outcomes of hospitalised patients with ischemic colitis with different degrees of haematochezia: a retrospective study. 62
35506923 2022
10
Ischemic and hemorrhagic abdominal complications in COVID-19 patients: experience from the first Italian wave. 62
36045452 2022
11
Results of the Galician registry in the treatment of complex aortoiliac aneurysms with GORE® EXCLUDER® Iliac Branch Endoprosthesis (GALIBER). 62
34114523 2022
12
Idiopathic Myointimal Hyperplasia of the Mesenteric Veins Is a Peculiar Venous Ischemia That May Be Diagnosed Before Surgery. 62
34803145 2022
13
A Case of Acute Cerebral Infarction With Chief Complaints of Abdominal Pain and Bloody Diarrhoea: The Power of a Patient-Centered Inclusive Diagnostic Team. 62
36046325 2022
14
Neutropenic Enterocolitis in a Patient With Acute Myeloid Leukemia. 62
35959178 2022
15
Failure to preserve the internal iliac artery during abdominal aortic aneurysm repair is associated with mortality and ischemic complications. 62
34954270 2022
16
A Case of Stercoral Colitis Complicated by Ischemic Colitis in a Young Patient. 62
35859979 2022
17
CD8+ Lymphocyte Infiltration Is a Specific Feature of Colitis Induced by Immune Checkpoint Inhibitors. 62
35748996 2022
18
Ischemic Colitis Is a Risk Factor for Clostridium difficile Infection. 62
35875313 2022
19
Mapping of etiologies of computed tomography-proven acute colitis: a prospective cohort study. 62
35697847 2022
20
Outcomes of patients with ischemic colitis causing severe hematochezia managed medically or surgically. 62
35187590 2022
21
NSAID-induced ischemic colitis. 62
35067065 2022
22
Ischemic colitis after COVID-19 mRNA vaccine. 62
35561992 2022
23
Ischemic Colitis in a Patient with Severe COVID-19 Pneumonia. 62
36157607 2022
24
Detection of Ischemic Colitis on Routine Lower Endoscopy and Its Implications After Repair of Ruptured Abdominal Aortic Aneurysm. 62
35574985 2022
25
Hydroxychloroquine safety in Covid-19 vs non-Covid-19 patients: analysis of differences and potential interactions. 62
35574687 2022
26
Mesenteric ischemia in patients with COVID-19: an updated systematic review of abdominal CT findings in 75 patients. 62
34761305 2022
27
Isolated Ruptured Paravisceral Penetrating Aortic Ulcers. 62
34780950 2022
28
Lactulose-Induced Ischemic Colitis: A Rare Presentation and an Overview of Possible Etiologies of the Disease. 62
35509729 2022
29
Congestive Heart Failure Is Associated With Worse Outcomes in Patients With Ischemic Colitis: A Nationwide Study. 62
35602840 2022
30
Clinical features and risk factors for ischemic colitis in young and middle-aged patients. 62
35709772 2022
31
Ischemic colitis after receiving the second dose of a COVID-19 inactivated vaccine: A case report. 62
35647139 2022
32
Factors influencing hospital stay duration for patients with mild ischemic colitis: a retrospective study. 62
35246255 2022
33
Hypereosinophilic syndrome presenting as coagulopathy. 62
35317854 2022
34
Ischemic Colitis in an Immunocompetent Patient. 62
34842450 2022
35
Acute right-sided ischemic colitis in a COVID-19 patient: a case report and review of the literature. 62
35337362 2022
36
Takayasu Arteritis Complicated by Ischemic Colitis: A Case Report. 62
35432647 2022
37
Emphasis on Early Identification of Risk Factors to Curtail High Mortality Involved With Ischemic Colitis (IC) After Abdominal Aortic Aneurysm (AAA) Repair. 62
35503664 2022
38
Colo-enteric fistula associated with diffuse large B cell lymphoma that resulted in gastrointestinal bleeding: A case report and literature review. 62
35131626 2022
39
NOBLADS-External Validation of a Risk Scoring System for Severe Acute Lower Gastrointestinal Bleeding. 62
34636778 2022
40
Ischemic colitis. Does right colon location mean worst prognosis? 62
35120849 2022
41
Causes of gastrointestinal bleeding in oral anticoagulant users compared to non-users in a population-based study. 62
34749581 2022
42
Gastrointestinal Manifestations of COVID-19 Infection: Clinicopathologic Findings in Intestinal Resections Performed at Single Institution. 62
35237625 2022
43
An Israeli national survey on ischemic colitis induced by pre-colonoscopy bowel preparation (R1). 62
35304999 2022
44
Ischemic colitis as a cause of severe hematochezia: A mini review. 62
36092274 2022
45
Abdominopelvic actinomycosis: An unexpected diagnosis in an elderly female with a destructive-appearing soft tissue mass. 62
35345557 2022
46
Smooth muscle degeneration of the mesenteric and branching veins causing ischemic enteritis: a case report. 62
34982272 2022
47
COVID-19-Associated Ischemic Colitis: A Rare Manifestation of COVID-19 Infection-Case Report and Review. 62
35343847 2022
48
Helicobacter pylori infection manifesting as Hypereosinophilic syndrome and immune thrombocytopenia complicated by portal vein thrombosis and ischemic colitis. 62
35242558 2022
49
A Case of Ischemic Colitis Complicated by Clostridioides Difficile Infection Treated with Fecal Microbiota Transplantation. 62
35045605 2022
50
Methamphetamine-Induced Bowel Ischemia in a 50-Year-Old Male. 62
35402052 2022

Variations for Ischemic Colitis

Expression for Ischemic Colitis

Search GEO for disease gene expression data for Ischemic Colitis.

Pathways for Ischemic Colitis

GO Terms for Ischemic Colitis

Cellular components related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.65 SERPINC1 IL6 F2 ALB ACE2
2 plasma membrane GO:0005887 9.64 TNF NPR3 HTR3A HTR2B F3 CCR6
3 plasma membrane GO:0005886 9.64 TNF NPR3 HTR3A HTR2B F3 CCR6

Biological processes related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.8 IL6 F2 CRP
2 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.73 TNF IL6 F2
3 vascular endothelial growth factor production GO:0010573 9.67 TNF IL6
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.43 TNF NPR3 HTR2B
5 hemostasis GO:0007599 9.33 SERPINC1 F3 F2
6 negative regulation of lipid storage GO:0010888 9.1 TNF IL6 CRP

Molecular functions related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.46 ATP4A ATP12A
2 P-type potassium transmembrane transporter activity GO:0008556 8.96 ATP4A ATP12A
3 P-type potassium:proton transporter activity GO:0008900 8.92 ATP4A ATP12A

Sources for Ischemic Colitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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