MCID: ISC015
MIFTS: 44

Ischemic Colitis

Categories: Blood diseases, Gastrointestinal diseases

Aliases & Classifications for Ischemic Colitis

MalaCards integrated aliases for Ischemic Colitis:

Name: Ischemic Colitis 12 15
Colitis, Ischemic 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060181
MeSH 43 D017091
SNOMED-CT 67 30588004
ICD10 32 K55.9
UMLS 71 C0162529

Summaries for Ischemic Colitis

Disease Ontology : 12 A colitis caused by inadequate blood supply to the colon.

MalaCards based summary : Ischemic Colitis, also known as colitis, ischemic, is related to arteriovenous malformation and aortic aneurysm. An important gene associated with Ischemic Colitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Anti-Inflammatory Agents and Anti-Inflammatory Agents, Non-Steroidal have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and... more...

Related Diseases for Ischemic Colitis

Diseases related to Ischemic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 527)
# Related Disease Score Top Affiliating Genes
1 arteriovenous malformation 30.5 VEGFA MMP9 MMP2
2 aortic aneurysm 30.4 MMP9 MMP2 CRP ACE
3 aortic aneurysm, familial abdominal, 1 30.4 MMP9 MMP2 CRP ACE
4 peritonitis 30.3 SERPINE1 F2 CRP
5 ischemia 30.2 VEGFA HMOX1 HIF1A ACE
6 thrombophilia due to thrombin defect 30.1 SERPINE1 SERPINC1 F5 F2 APOH
7 inguinal hernia 30.1 MMP9 MMP2 ACE
8 catastrophic antiphospholipid syndrome 30.1 SERPINE1 F5 APOH
9 polycythemia 30.1 JAK2 HIF1A F5
10 hepatic veno-occlusive disease 30.0 VEGFA SERPINE1 SERPINC1
11 portal hypertension 30.0 VEGFA SERPINE1 JAK2 F2 ACE
12 prothrombin deficiency, congenital 30.0 SERPINC1 F5 F2 APOH
13 protein s deficiency 30.0 SERPINE1 SERPINC1 F5 F2 APOH
14 transverse myelitis 29.9 MMP9 MMP2 APOH
15 thrombophilia due to activated protein c resistance 29.8 SERPINE1 SERPINC1 F5 F2 APOH
16 hemorrhoid 29.8 MMP9 F2 CRP
17 thrombosis 29.7 SERPINE1 SERPINC1 JAK2 F5 F2 APOH
18 cholesterol embolism 29.7 SERPINC1 F2 CRP ACE
19 antithrombin iii deficiency 29.7 SERPINC1 JAK2 F5 F2 APOH
20 budd-chiari syndrome 29.7 SERPINC1 JAK2 F5 F2 APOH
21 myelitis 29.7 MMP9 CCR6 APOH
22 paralytic ileus 29.7 HTR3A F2 CRP
23 migraine with or without aura 1 29.7 HTR3A F2 CRP APOH ACE
24 thrombophilia 29.6 SERPINE1 SERPINC1 JAK2 F5 F2 APOH
25 proctitis 29.6 VEGFA CRP CCR6
26 eclampsia 29.6 VEGFA SERPINE1 SERPINC1 F2 ACE
27 heart valve disease 29.6 F2 CRP APOH ACE
28 diverticulitis 29.6 MMP9 CRP CCR6
29 antiphospholipid syndrome 29.5 SERPINE1 SERPINC1 F5 F2 CRP APOH
30 acute myocardial infarction 29.5 SERPINE1 SERPINC1 MMP9 CRP ACE
31 pelvic organ prolapse 29.5 MMP9 MMP2 CCR6
32 purpura 29.4 SERPINC1 F2 CRP APOH ACE
33 chronic kidney disease 29.4 VEGFA SERPINE1 HMOX1 CRP ACE
34 kidney disease 29.4 VEGFA SERPINE1 HMOX1 CRP ACE
35 disseminated intravascular coagulation 29.3 SERPINE1 SERPINC1 F5 F2 CRP
36 peripheral vascular disease 29.2 VEGFA SERPINE1 SERPINC1 F5 F2 CRP
37 connective tissue disease 29.2 VEGFA CRP CCR6 APOH ACE
38 lung disease 29.2 VEGFA MMP9 HMOX1 CRP ACE
39 chronic venous insufficiency 29.2 VEGFA SERPINE1 MMP9 F2 CRP
40 atherosclerosis susceptibility 29.1 VEGFA SERPINE1 MMP9 CRP ACE
41 thrombophlebitis 29.0 SERPINE1 SERPINC1 F5 F2 CRP APOH
42 deficiency anemia 29.0 JAK2 HMOX1 HIF1A CRP ACE
43 exanthem 28.9 VEGFA F2 CRP CCR6 ACE
44 venous insufficiency 28.9 VEGFA SERPINE1 MMP9 F5 F2 CRP
45 arteriosclerosis 28.9 SERPINE1 SERPINC1 MMP9 HMOX1 HIF1A CRP
46 takayasu arteritis 28.9 SERPINC1 MMP9 MMP2 F2 CRP APOH
47 varicose veins 28.8 VEGFA SERPINC1 MMP9 MMP2 HIF1A F5
48 pulmonary embolism 28.8 SERPINE1 SERPINC1 F5 F2 CRP APOH
49 portal vein thrombosis 28.7 SERPINE1 SERPINC1 JAK2 F5 F2 CRP
50 thrombocytopenia 28.7 SERPINE1 SERPINC1 JAK2 F5 F2 CRP

Graphical network of the top 20 diseases related to Ischemic Colitis:



Diseases related to Ischemic Colitis

Symptoms & Phenotypes for Ischemic Colitis

MGI Mouse Phenotypes related to Ischemic Colitis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 ACE CCR6 CRP F2 F5 HIF1A
2 homeostasis/metabolism MP:0005376 10.36 ACE APOH CCR6 CRP F2 F5
3 hematopoietic system MP:0005397 10.29 ACE CCR6 F2 HIF1A HMOX1 HTR3A
4 immune system MP:0005387 10.28 ACE CCR6 CRP F2 HIF1A HMOX1
5 growth/size/body region MP:0005378 10.27 ACE F2 F5 HIF1A HMOX1 HTR3A
6 mortality/aging MP:0010768 10.17 ACE APOH F2 F5 HIF1A HMOX1
7 integument MP:0010771 10.01 F2 F5 HIF1A HTR3A JAK2 MMP9
8 liver/biliary system MP:0005370 9.97 ACE F5 HIF1A HMOX1 JAK2 SERPINC1
9 renal/urinary system MP:0005367 9.81 ACE HIF1A HMOX1 HTR3A MMP9 NPR3
10 neoplasm MP:0002006 9.8 ACE HIF1A JAK2 MMP2 MMP9 SERPINE1
11 reproductive system MP:0005389 9.61 ACE F2 HMOX1 HTR3A JAK2 MMP9
12 respiratory system MP:0005388 9.23 F2 HIF1A HMOX1 JAK2 MMP2 MMP9

Drugs & Therapeutics for Ischemic Colitis

Drugs for Ischemic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Inflammatory Agents Phase 2, Phase 3
2 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
3 Analgesics, Non-Narcotic Phase 2, Phase 3
4 Mesalamine Phase 2, Phase 3 89-57-6
5 Antirheumatic Agents Phase 2, Phase 3
6 Analgesics Phase 2, Phase 3
7
Coal tar Approved 8007-45-2
8 Cola
9 Anti-Bacterial Agents
10 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Mesalazine on Low Grade Mucosal Inflammation in Irritable Bowel Syndrome. A Pilot Double Blind Placebo Controlled Study. Completed NCT00774007 Phase 2, Phase 3 mesalazine;placebo
2 A Multicentre Trial of the Anterior Perineal PlanE for Ultra Low Anterior Resection of the Rectum (The APPEAR Technique) in the Prevention of Permanent Stoma in Benign and Malignant Disease Unknown status NCT00534131
3 Ischemic Colitis Is a Common Cause of Severe Hematochezia and Patient Outcomes Are Worse Than With Other Colonic Diagnoses Completed NCT01078324
4 Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy (DECLAM). Recruiting NCT03450512

Search NIH Clinical Center for Ischemic Colitis

Cochrane evidence based reviews: colitis, ischemic

Genetic Tests for Ischemic Colitis

Anatomical Context for Ischemic Colitis

MalaCards organs/tissues related to Ischemic Colitis:

40
Colon, Heart, Kidney, Lung, Myeloid, Bone, Liver

Publications for Ischemic Colitis

Articles related to Ischemic Colitis:

(show top 50) (show all 1488)
# Title Authors PMID Year
1
A multiple myeloma patient who developed ischemic colitis during lenalidomide treatment: A rare case report. 61
32028837 2020
2
Histopathologic Patterns of Colitis in Patients With Impaired Renal Function. 61
31679016 2020
3
Young-Onset Ischemic Colitis: A Condition of Elusive Etiology Frequently Associated With Immune Dysregulation. 61
31870209 2019
4
Clostridium difficile colitis: CT findings and differential diagnosis. 61
31302848 2019
5
Multiparametric ultrasound in the diagnosis and monitoring of ischemic colitis: description of a case of ischemic colitis of the right colon and revision of the literature. 61
31119715 2019
6
Acute ischemic colitis with hematochezia related to baloxavir marboxil treatment for influenza A. 61
31176533 2019
7
Insights into the pathogenesis of catastrophic antiphospholipid syndrome. A case report of relapsing catastrophic antiphospholipid syndrome and review of the literature on ischemic colitis. 61
31853731 2019
8
Changes in Lower Gastrointestinal Bleeding Presentation, Management, and Outcomes Over a 10-Year Span. 61
31593973 2019
9
It's not always cancer: ischemic colitis masquerading as a colonic mass. 61
31733198 2019
10
Combination Treatment with Antibiotics and Glucocorticosteroids for Severe Ischemic Colitis. 61
31694014 2019
11
Challenging case of ischemic colitis, necrotic cutaneous vasculitis and thromboembolic disease in an elderly patient with Sjogren's syndrome. 61
31844526 2019
12
Ischemic Colitis Secondary to Dextromethorphan Overdose. 61
31033494 2019
13
Point-of-Care Ultrasound to Diagnose Colitis in the Emergency Department: A Case Series and Review of the Literature. 61
31672400 2019
14
The Pathophysiology, Presentation and Management of Ischaemic Colitis: A Systematic Review. 61
31646369 2019
15
Recurrent stent thrombosis in a patient with acute coronary syndrome and ischemic colitis: between life-threatening thrombosis and life-threatening bleeding. 61
31607192 2019
16
Colonic Ischemia After Vaginal Delivery. 61
31832455 2019
17
Co-Infections of Two Strains of NDM-1 and OXA-232 Co-producing Klebsiella pneumoniae in a Kidney Transplant Patient. 61
31527031 2019
18
A RARE CASE OF ISCHEMIC COLITIS: CEFUROXIME-RELATED ANAPHYLACTIC SHOCK. 61
31574074 2019
19
Ischemic Colitis Associated with Rhabdomyolysis and Heat Stroke after an Intense Exercise in Young Adult. 61
31438663 2019
20
[Clinical analysis of peri-operative gastrointestinal complications after endovascular and open repair of abdominal aortic aneurysm]. 61
31422628 2019
21
Preservation of pelvic perfusion with iliac branch devices does not decrease ischemic colitis compared with hypogastric embolization in endovascular abdominal aortic aneurysm repair. 61
31471238 2019
22
Hypogastric artery coverage during endovascular aneurysm repair in octogenarian and younger patients. 61
30950984 2019
23
Diverticular Disease in the Elderly. 61
31346801 2019
24
A rare cause of colic polyp in a patient with ischemic colitis. 61
31566340 2019
25
Stent-assisted balloon-induced intimal disruption and relamination of distal remaining aortic dissection after acute DeBakey type I repair. 61
30501951 2019
26
Assessing trends, morbidity, and mortality in ruptured abdominal aortic aneurysm repair with nine years of data from the National Surgical Quality Improvement Program. 61
31227411 2019
27
Inferior mesenteric artery replantation does not decrease the risk of ischemic colitis after open infrarenal abdominal aortic aneurysm repair. 61
30591291 2019
28
[Rectal Ulcer Developed in Systemic Lupus Erythematosus without Ischemic Colitis]. 61
31132828 2019
29
Ischemic Colitis. 61
30850260 2019
30
Ischemic Colitis in Association with Sevelamer Crystals. 61
31142966 2019
31
SEVERE ISCHEMIC COLITIS PROBABLY RELATED TO DICLOFENAC. 61
31145258 2019
32
The Colonic Single Stripe Sign: A Case of Ischemic Colitis. 61
31281764 2019
33
Robotic-assisted laparoscopic repair of rectovesical fistula after Hartmann's reversal procedure. 61
30062640 2019
34
Bladder necrosis and perforation in end-stage renal disease and recurrent urinary tract infection: A rare medical emergency. 61
31334054 2019
35
Jejunal perforation complicating dermatomyositis. 61
31734477 2019
36
Dosing of Antimycotic Treatment in Sepsis-Induced Liver Dysfunction by Functional Liver Testing with LiMAx®. 61
31949955 2019
37
The Effect of Surgical Training and Operative Approach on Outcomes in Acute Diverticulitis: Should Guidelines Be Revised? 61
30451762 2019
38
Mass-Forming Ischemic Colitis: A Potential Mimicker of Malignancy. 61
31007961 2019
39
Infection due to Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) presenting as ischemic colitis. 61
31528540 2019
40
Phlebosclerotic Colitis - An Enigma Among Ischemic Colitis. 61
31448169 2019
41
Ischemic colitis due to antiphospholipid antibody syndrome. 61
30793065 2019
42
Melanosis Coli: A Case of Mistaken Identity-A Case Report. 61
30624202 2019
43
Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency. 61
31080679 2019
44
Self-administered alcohol enema causing chemical proctocolitis. 61
31354369 2019
45
Stent-assisted, balloon-induced intimal disruption and relamination of aortic dissection in patients with Marfan syndrome: Midterm outcomes and aortic remodeling. 61
29934004 2018
46
Endovascular Treatment of an Inferior Mesenteric Arteriovenous Malformation Causing Ischemic Colitis. 61
30368321 2018
47
Atypical cause of intractable diarrhea in a hemodialysis patient, masked by Clostridium difficile-associated diarrhea and ischemic colitis: a case report. 61
30384836 2018
48
Repeat Ischemic Colitis in a Patient Taking Quetiapine. 61
30476377 2018
49
Gastrointestinal: "Ghost gland" in probe-based confocal laser endomicroscopy for diagnosing ischemic colitis: A novel approach. 61
30022516 2018
50
Hypogastric Preservation Using Retrograde Endovascular Bypass. 61
29908227 2018

Variations for Ischemic Colitis

Expression for Ischemic Colitis

Search GEO for disease gene expression data for Ischemic Colitis.

Pathways for Ischemic Colitis

Pathways related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 VEGFA SERPINE1 MMP9 MMP2 JAK2 F2
2
Show member pathways
13.2 VEGFA SERPINE1 SERPINC1 JAK2 F5 F2
3 12.42 VEGFA MMP9 MMP2 JAK2 HMOX1 HIF1A
4 12.19 VEGFA MMP9 MMP2 HIF1A
5
Show member pathways
12.11 VEGFA SERPINE1 JAK2 HIF1A
6
Show member pathways
12.07 SERPINE1 SERPINC1 F5 F2
7 12.01 SERPINE1 SERPINC1 F5 F2
8 11.97 VEGFA MMP9 MMP2 HMOX1
9 11.82 VEGFA SERPINE1 HMOX1 HIF1A
10 11.73 VEGFA SERPINE1 MMP2 JAK2
11 11.65 VEGFA MMP9 MMP2
12 11.62 MMP9 MMP2 HMOX1 HIF1A
13
Show member pathways
11.58 VEGFA MMP9 MMP2
14 11.57 MMP9 MMP2 HMOX1
15 11.55 SERPINE1 MMP9 MMP2
16 11.44 MMP9 MMP2 JAK2 HIF1A
17 11.37 VEGFA SERPINE1 HMOX1 HIF1A
18 11.28 VEGFA SERPINE1 HIF1A
19 11.22 MMP9 MMP2 HMOX1
20 11.18 MMP9 MMP2 ACE
21 11.16 VEGFA MMP9 MMP2 JAK2 HMOX1 HIF1A
22 11.01 VEGFA MMP9 HIF1A
23 10.94 MMP9 MMP2 ACE
24
Show member pathways
10.73 VEGFA JAK2 HIF1A CRP
25 10.57 VEGFA HIF1A

GO Terms for Ischemic Colitis

Cellular components related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 VEGFA SERPINE1 SERPINC1 MMP9 MMP2 F5
2 platelet alpha granule lumen GO:0031093 9.43 VEGFA SERPINE1 F5
3 collagen-containing extracellular matrix GO:0062023 9.43 SERPINE1 SERPINC1 MMP9 MMP2 F2 APOH
4 extracellular space GO:0005615 9.36 VEGFA SERPINE1 SERPINC1 MMP9 MMP2 HMOX1

Biological processes related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.87 SERPINC1 MMP2 F5 F2
2 blood coagulation GO:0007596 9.85 SERPINC1 JAK2 F5 F2
3 response to hypoxia GO:0001666 9.78 VEGFA MMP2 HMOX1 HIF1A
4 regulation of blood pressure GO:0008217 9.73 NPR3 HMOX1 ACE
5 angiogenesis GO:0001525 9.72 VEGFA SERPINE1 MMP2 HMOX1 HIF1A
6 positive regulation of angiogenesis GO:0045766 9.71 VEGFA SERPINE1 HMOX1 HIF1A
7 hemostasis GO:0007599 9.69 SERPINC1 F5 F2
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.67 MMP9 MMP2 JAK2
9 platelet degranulation GO:0002576 9.67 VEGFA SERPINE1 F5 APOH
10 lactation GO:0007595 9.63 VEGFA SERPINC1 HIF1A
11 response to amyloid-beta GO:1904645 9.59 MMP9 MMP2
12 negative regulation of blood coagulation GO:0030195 9.58 SERPINE1 APOH
13 positive regulation of receptor biosynthetic process GO:0010870 9.58 JAK2 HIF1A
14 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.54 VEGFA HIF1A
15 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.52 HMOX1 HIF1A
16 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.43 VEGFA ACE
17 positive regulation of blood coagulation GO:0030194 9.43 SERPINE1 F2 APOH
18 regulation of blood coagulation GO:0030193 9.33 SERPINC1 F2 APOH
19 negative regulation of fibrinolysis GO:0051918 9.13 SERPINE1 F2 APOH
20 cytokine-mediated signaling pathway GO:0019221 9.1 VEGFA MMP9 MMP2 JAK2 HMOX1 HIF1A

Molecular functions related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride ion binding GO:0031404 8.96 NPR3 ACE
2 heparin binding GO:0008201 8.92 VEGFA SERPINC1 F2 APOH

Sources for Ischemic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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