MCID: ISC015
MIFTS: 46

Ischemic Colitis

Categories: Blood diseases, Gastrointestinal diseases

Aliases & Classifications for Ischemic Colitis

MalaCards integrated aliases for Ischemic Colitis:

Name: Ischemic Colitis 12 15
Colitis, Ischemic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060181
MeSH 45 D017091
SNOMED-CT 69 30588004
ICD10 34 K55.9
UMLS 74 C0162529

Summaries for Ischemic Colitis

Disease Ontology : 12 A colitis caused_by inadequate blood supply to the colon.

MalaCards based summary : Ischemic Colitis, also known as colitis, ischemic, is related to arteriovenous fistula and antiphospholipid syndrome. An important gene associated with Ischemic Colitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and G-protein signaling Ras family GTPases in kinase cascades (scheme). The drugs Coal tar and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include colon, myeloid and lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 77 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and... more...

Related Diseases for Ischemic Colitis

Diseases related to Ischemic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 arteriovenous fistula 30.1 APOH HMOX1
2 antiphospholipid syndrome 29.7 APOH F2 F5 SERPINC1
3 purpura 29.6 APOH F2 SERPINC1
4 coronary artery anomaly 29.5 F2 F5 SERPINE1
5 disseminated intravascular coagulation 29.3 F2 F5 SERPINC1 SERPINE1
6 polycythemia 29.2 F5 HIF1A JAK2
7 thrombophilia due to thrombin defect 29.1 APOH F2 F5 SERPINC1 SERPINE1
8 thrombosis 29.1 APOH F2 F5 JAK2 SERPINC1 SERPINE1
9 myocardial infarction 28.9 F2 F5 HIF1A SERPINC1 SERPINE1
10 budd-chiari syndrome 28.9 APOH F2 F5 JAK2 SERPINC1
11 pulmonary embolism 28.9 APOH F2 F5 SERPINC1 SERPINE1
12 portal vein thrombosis 28.4 APOH F2 F5 JAK2 SERPINC1 SERPINE1
13 colitis 11.1
14 arteritic anterior ischemic optic neuropathy 10.3 F2 F5
15 paracetamol poisoning 10.3 F2 F5
16 may-thurner syndrome 10.3 APOH F5
17 leech infestation 10.2 F2 SERPINC1
18 intestinal impaction 10.2 F2 SERPINC1
19 fournier gangrene 10.2 F2 SERPINC1
20 hemoglobin e disease 10.2 F2 F5
21 acanthamoeba keratitis 10.2 APOH F5
22 factor viii deficiency 10.2 F2 F5
23 hemorrhagic fever 10.2 F2 SERPINC1
24 porencephaly 10.2 F2 F5
25 alpha-2-plasmin inhibitor deficiency 10.2 F2 SERPINC1
26 pregnancy loss, recurrent 1 10.2 APOH F5
27 intracranial embolism 10.2 F2 SERPINC1
28 systemic lupus erythematosus 10.2
29 lupus erythematosus 10.2
30 giant hemangioma 10.2 F2 SERPINC1
31 korean hemorrhagic fever 10.2 F2 SERPINC1
32 marantic endocarditis 10.2 F2 SERPINC1
33 inferior vena cava interruption 10.2 F5 SERPINE1
34 purpura fulminans 10.2 F2 SERPINC1
35 amaurosis fugax 10.2 F5 SERPINE1
36 aortic aneurysm 10.2
37 esophageal varix 10.2 F2 SERPINC1
38 anterior spinal artery syndrome 10.2 F2 SERPINC1
39 fibrinolytic defect 10.2 SERPINC1 SERPINE1
40 hypersplenism 10.2 F2 SERPINC1
41 inherited blood coagulation disease 10.2 F2 SERPINC1
42 carotid artery occlusion 10.2 APOH F5
43 aortic aneurysm, familial abdominal, 1 10.2
44 acute liver failure 10.2 F2 F5
45 aspirin allergy 10.2 SERPINC1 SERPINE1
46 papilledema 10.2 APOH F2
47 argentine hemorrhagic fever 10.2 SERPINC1 SERPINE1
48 factor xi deficiency 10.2 F2 SERPINC1
49 quebec platelet disorder 10.2 F5 SERPINE1
50 thrombasthenia 10.2 F2 F5

Graphical network of the top 20 diseases related to Ischemic Colitis:



Diseases related to Ischemic Colitis

Symptoms & Phenotypes for Ischemic Colitis

MGI Mouse Phenotypes related to Ischemic Colitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.92 APOH F2 F5 HIF1A HMOX1 JAK2
2 cardiovascular system MP:0005385 9.91 F2 F5 HIF1A HMOX1 SERPINC1 SERPINE1
3 hematopoietic system MP:0005397 9.85 F2 HIF1A HMOX1 JAK2 SERPINC1 SERPINE1
4 embryo MP:0005380 9.8 F2 F5 HIF1A JAK2 SERPINC1
5 immune system MP:0005387 9.73 F2 HIF1A HMOX1 JAK2 SERPINC1 SERPINE1
6 integument MP:0010771 9.55 F2 F5 HIF1A JAK2 SERPINE1
7 liver/biliary system MP:0005370 9.43 F5 HIF1A HMOX1 JAK2 SERPINC1 SERPINE1
8 mortality/aging MP:0010768 9.23 APOH F2 F5 HIF1A HMOX1 JAK2

Drugs & Therapeutics for Ischemic Colitis

Drugs for Ischemic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Coal tar Approved 8007-45-2
2 Anesthetics Not Applicable
3 Cola
4 Anti-Bacterial Agents
5 Antibiotics, Antitubercular
6 Plasma Substitutes Not Applicable
7 Dextrans Not Applicable
8 Angiogenesis Inhibitors Not Applicable
9 tyrosine Not Applicable
10 Anticoagulants Not Applicable
11 Blood Substitutes Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preconditioning Shields Against Vascular Events in Surgery Unknown status NCT02097186 Not Applicable
2 Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum Unknown status NCT00534131 Not Applicable
3 Study of Ischemic Colitis Compared to Other Diagnoses in Patients With Lower Gastrointestinal Bleeding Completed NCT01078324
4 Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy Recruiting NCT03450512
5 Study to Explore Morbimortality in Patients Dialyzed With the Theranova HDx in Comparison to On-Line-Hemodiafiltration Not yet recruiting NCT03714386 Not Applicable
6 Determination of the Aetiologies of Acute Colitis and Early Identification of Patients Requiring Diagnostic Colonoscopy Recruiting NCT02709213
7 Iliac Branch Device Movement During Cardiac Cycle (IBD-dynamics) Recruiting NCT03762525 Not Applicable
8 Preconditioning Shields Against Vascular Events in Surgery Completed NCT01691911 Not Applicable
9 Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery Completed NCT01404910 Not Applicable

Search NIH Clinical Center for Ischemic Colitis

Cochrane evidence based reviews: colitis, ischemic

Genetic Tests for Ischemic Colitis

Anatomical Context for Ischemic Colitis

MalaCards organs/tissues related to Ischemic Colitis:

42
Colon, Myeloid, Lung, Liver, Bone, Heart, Bone Marrow

Publications for Ischemic Colitis

Articles related to Ischemic Colitis:

(show top 50) (show all 579)
# Title Authors Year
1
Ischemic Colitis. ( 30850260 )
2019
2
Ischemic colitis due to antiphospholipid antibody syndrome. ( 30793065 )
2019
3
Ischemic Colitis in Sickle Cell Disease: A Case Report of a Diagnostic Challenge. ( 29623225 )
2018
4
Ischemic colitis following left antegrade sclerotherapy for idiopathic varicocele. ( 29473213 )
2018
5
Gas In The Hepatic Portal Venous System Associated With Ischemic Colitis. ( 29880969 )
2018
6
Magnesium poisoning, multi-organ failure and ischemic colitis secondary to chronic ingestion of a parapharmacy product. ( 29667416 )
2018
7
Thumbprinting in Ischemic Colitis. ( 29897854 )
2018
8
Ischemic colitis following infrarenal abdominal aortic aneurysm treatment: Results from a tertiary medical center. ( 30688933 )
2018
9
Inferior mesenteric artery replantation does not decrease the risk of ischemic colitis after open infrarenal abdominal aortic aneurysm repair. ( 30591291 )
2018
10
Endovascular Treatment of an Inferior Mesenteric Arteriovenous Malformation Causing Ischemic Colitis. ( 30368321 )
2018
11
Repeat Ischemic Colitis in a Patient Taking Quetiapine. ( 30476377 )
2018
12
One Oral Dose of Sodium Polystyrene Sulfonate Associated with Ischemic Colitis and Crystal Deposition in Colonic Mucosa. ( 30370313 )
2018
13
Atypical cause of intractable diarrhea in a hemodialysis patient, masked by Clostridium difficile-associated diarrhea and ischemic colitis: a case report. ( 30384836 )
2018
14
Successful Laparoscopy-Assisted Resection of the Descending Colon in a Patient with Multiple Large Renal Cysts and Stricture of the Colon due to Ischemic Colitis. ( 30283290 )
2018
15
A Case-control Study on the Risk Factors for Ischemic Colitis. ( 30191546 )
2018
16
Ischemic colitis caused by polycythemia vera: A case report and literature review. ( 30233723 )
2018
17
Therapeutic effects of Ginkgo biloba extract against acute ischemic colitis. ( 30170462 )
2018
18
Ischemic colitis after translumbar n-butyl cyanoacrylate injection for treatment of endoleak. ( 30175300 )
2018
19
Gastrointestinal: "Ghost gland" in probe-based confocal laser endomicroscopy for diagnosing ischemic colitis: A novel approach. ( 30022516 )
2018
20
Pseudoephedrine Induced Ischemic Colitis: A Case Report and Review of Literature. ( 30050703 )
2018
21
Ischemic colitis caused increased early and delayed mortality. ( 30008799 )
2018
22
'Runs' from a run: A case of exercise induced ischemic colitis. ( 29123610 )
2017
23
Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center. ( 28769977 )
2017
24
The incidence and outcome of ischemic colitis in a population-based setting. ( 28276832 )
2017
25
Association between lower air pressure and the onset of ischemic colitis: a case-control study. ( 28562393 )
2017
26
Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination. ( 28878651 )
2017
27
Severe Cytomegalovirus Infection Masquerading as Recurrent Ischemic Colitis in a Patient with End-Stage Renal Disease. ( 29299486 )
2017
28
The Incidence of Ischemic Colitis after Repair of Ruptured Abdominal Aortic Aneurysms is Decreasing in the Endovascular Era. ( 28919522 )
2017
29
Pemetrexed-associated Ischemic Colitis in Nonsmall Cell Lung Cancer. ( 28685736 )
2017
30
Fulminant gangrenous ischemic colitis: is it the solely severe type of ischemic colitis? ( 27838817 )
2017
31
Predictors of severity in ischemic colitis: Usefulness of early ultrasonography. ( 29103470 )
2017
32
Idiopathic Myointimal Hyperplasia of Mesenteric Veins: An Uncommon Cause of Ischemic Colitis With Distinct Mucosal Features. ( 28817406 )
2017
33
Cytomegalovirus: associated ischemic colitis in an immunocompetent patient. ( 28747055 )
2017
34
18F-FDG Uptake in Ischemic Colitis During Follow-up of a Patient With Lung Cancer. ( 28632689 )
2017
35
Predictive factors of mortality after colectomy in ischemic colitis: an ACS-NSQIP database study. ( 29766117 )
2017
36
Advents in the Diagnosis and Management of Ischemic Colitis. ( 28929100 )
2017
37
Pseudoephedrine Associated Ischemic Colitis. ( 28786857 )
2017
38
Ischemic colitis of the colon in streptozotocin-induced diabetic rats. ( 28780750 )
2017
39
Seasonal variation in occurrence of ischemic colitis: a retrospective study. ( 28222619 )
2017
40
Identification of the distinguishing features of Crohn's disease and ischemic colitis using computed tomographic enterography. ( 28852526 )
2017
41
Gastrointestinal: Phlebosclerotic colitis: A rare but increasingly recognized cause of ischemic colitis with telltale imaging features. ( 29024011 )
2017
42
Stercoral colitis complicated with ischemic colitis: a double-edge sword. ( 29179680 )
2017
43
Tubercular colitis masquerading as ischemic colitis: An unusual presentation. ( 29171457 )
2017
44
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. ( 26943694 )
2016
45
Ischemic colitis associated with acute carbon monoxide poisoning--a case report. ( 27265995 )
2016
46
Beyond Low Flow: How I Manage Ischemic Colitis. ( 27725651 )
2016
47
Anorexia nervosa hyperactivity-induced ischemic colitis (ANHIC): a new cause of anaemia. ( 27314583 )
2016
48
Severe ischemic colitis following olanzapine use - A case report. ( 26786111 )
2016
49
Ischemic Colitis as a Complication of Medication Use: An Analysis of the Federal Adverse Event Reporting System. ( 27073073 )
2016
50
Ischemic colitis following uncomplicated colonoscopy. ( 26751116 )
2016

Variations for Ischemic Colitis

Expression for Ischemic Colitis

Search GEO for disease gene expression data for Ischemic Colitis.

Pathways for Ischemic Colitis

Pathways related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 APOH F2 F5 JAK2 SERPINC1 SERPINE1
2
Show member pathways
11.84 HIF1A JAK2 SERPINE1
3 11.6 HIF1A HMOX1 JAK2
4 11.5 HIF1A HMOX1 SERPINE1
5
Show member pathways
11.46 F2 F5 SERPINC1 SERPINE1
6 11.25 HIF1A HMOX1 SERPINE1
7 11.16 HIF1A JAK2
8 11.07 F2 F5 SERPINC1 SERPINE1
9 11.02 HIF1A SERPINE1
10
Show member pathways
10.91 HIF1A JAK2

GO Terms for Ischemic Colitis

Cellular components related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.33 F2 F5 SERPINC1
2 collagen-containing extracellular matrix GO:0062023 9.13 APOH SERPINC1 SERPINE1
3 extracellular space GO:0005615 9.1 APOH F2 F5 HMOX1 SERPINC1 SERPINE1

Biological processes related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.77 F5 HIF1A SERPINC1
2 cytokine-mediated signaling pathway GO:0019221 9.75 HIF1A HMOX1 JAK2
3 angiogenesis GO:0001525 9.72 HIF1A HMOX1 SERPINE1
4 cellular protein metabolic process GO:0044267 9.7 F2 F5 SERPINC1
5 positive regulation of angiogenesis GO:0045766 9.65 HIF1A HMOX1 SERPINE1
6 negative regulation of neuron apoptotic process GO:0043524 9.61 HIF1A HMOX1 JAK2
7 cellular iron ion homeostasis GO:0006879 9.6 HIF1A HMOX1
8 lactation GO:0007595 9.58 HIF1A SERPINC1
9 platelet degranulation GO:0002576 9.58 APOH F5 SERPINE1
10 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.57 HMOX1 SERPINE1
11 negative regulation of DNA binding GO:0043392 9.56 HMOX1 JAK2
12 blood coagulation GO:0007596 9.56 F2 F5 JAK2 SERPINC1
13 positive regulation of macroautophagy GO:0016239 9.54 HIF1A HMOX1
14 fibrinolysis GO:0042730 9.51 F2 SERPINE1
15 hemostasis GO:0007599 9.5 F2 F5 SERPINC1
16 blood coagulation, intrinsic pathway GO:0007597 9.49 APOH F2
17 negative regulation of blood coagulation GO:0030195 9.46 APOH SERPINE1
18 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 9.37 HIF1A HMOX1
19 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
20 regulation of blood coagulation GO:0030193 9.13 APOH F2 SERPINC1
21 negative regulation of fibrinolysis GO:0051918 8.8 APOH F2 SERPINE1

Molecular functions related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Ischemic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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