MCID: ISC015
MIFTS: 42

Ischemic Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ischemic Colitis

MalaCards integrated aliases for Ischemic Colitis:

Name: Ischemic Colitis 12 15
Colitis, Ischemic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060181
ICD10 33 K55.9
MeSH 44 D017091
SNOMED-CT 68 30588004
UMLS 73 C0162529

Summaries for Ischemic Colitis

Disease Ontology : 12 A colitis caused_by inadequate blood supply to the colon.

MalaCards based summary : Ischemic Colitis, also known as colitis, ischemic, is related to antiphospholipid syndrome and pulmonary embolism. An important gene associated with Ischemic Colitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Anesthetics and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and... more...

Related Diseases for Ischemic Colitis

Diseases related to Ischemic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 antiphospholipid syndrome 29.0 APOH F2 F5 SERPINC1
2 pulmonary embolism 29.0 APOH F2 F5 SERPINC1
3 transverse myelitis 28.9 APOH MMP2 MMP9
4 thrombosis 28.1 APOH F2 F5 JAK2 SERPINC1
5 myocardial infarction 27.7 F2 F5 MMP2 MMP9 SERPINC1
6 colitis 10.7
7 sticky platelet syndrome 10.7 F5 SERPINC1
8 paracetamol poisoning 10.6 F2 F5
9 hemoglobin e disease 10.6 F2 F5
10 may-thurner syndrome 10.6 APOH F5
11 intestinal impaction 10.6 F2 SERPINC1
12 fournier gangrene 10.6 F2 SERPINC1
13 blood protein disease 10.6 F2 SERPINC1
14 acanthamoeba keratitis 10.6 APOH F5
15 leech infestation 10.6 F2 SERPINC1
16 alpha-2-plasmin inhibitor deficiency 10.6 F2 SERPINC1
17 cryptogenic cirrhosis 10.6 F2 F5
18 giant hemangioma 10.6 F2 SERPINC1
19 pregnancy loss, recurrent 1 10.6 APOH F5
20 factor viii deficiency 10.6 F2 F5
21 blue toe syndrome 10.6 F2 SERPINC1
22 porencephaly 10.6 F2 F5
23 intracranial embolism 10.6 F2 SERPINC1
24 meningococcemia 10.6 F5 SERPINC1
25 anterior spinal artery syndrome 10.5 F2 SERPINC1
26 subendocardial myocardial infarction 10.5 F2 SERPINC1
27 catastrophic antiphospholipid syndrome 10.5 APOH F5
28 legg-calve-perthes disease 10.5 F5 SERPINC1
29 marantic endocarditis 10.5 F2 SERPINC1
30 purpura fulminans 10.5 F2 SERPINC1
31 korean hemorrhagic fever 10.5 F2 SERPINC1
32 esophageal varix 10.5 F2 SERPINC1
33 inherited blood coagulation disease 10.5 F2 SERPINC1
34 splenic infarction 10.5 APOH F2
35 scott syndrome 10.5 F2 F5
36 papilledema 10.4 APOH F2
37 hypersplenism 10.4 F2 SERPINC1
38 arteritic anterior ischemic optic neuropathy 10.4 F2 F5
39 carotid artery occlusion 10.4 APOH F5
40 hemorrhagic fever 10.4 F2 SERPINC1
41 acute liver failure 10.4 F2 F5
42 factor xi deficiency 10.4 F2 SERPINC1
43 thrombasthenia 10.4 F2 F5
44 buerger disease 10.4 APOH F2
45 amaurosis fugax 10.4 F5 MMP9
46 hemophilia b 10.3 F2 SERPINC1
47 hepatitis a 10.3 F2 SERPINC1
48 afibrinogenemia 10.3 F2 F5
49 infective endocarditis 10.3 APOH F2
50 von willebrand's disease 10.3 F2 F5

Graphical network of the top 20 diseases related to Ischemic Colitis:



Diseases related to Ischemic Colitis

Symptoms & Phenotypes for Ischemic Colitis

MGI Mouse Phenotypes related to Ischemic Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 F5 HMOX1 MMP2 MMP9 SERPINC1 F2
2 homeostasis/metabolism MP:0005376 9.76 HMOX1 JAK2 MMP2 MMP9 APOH SERPINC1
3 hematopoietic system MP:0005397 9.73 HMOX1 JAK2 MMP2 MMP9 SERPINC1 F2
4 immune system MP:0005387 9.43 HMOX1 JAK2 MMP2 MMP9 SERPINC1 F2
5 mortality/aging MP:0010768 9.23 F5 HMOX1 JAK2 MMP2 MMP9 APOH

Drugs & Therapeutics for Ischemic Colitis

Drugs for Ischemic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Not Applicable
2 Angiogenesis Inhibitors Not Applicable
3 Anticoagulants Not Applicable
4 Blood Substitutes Not Applicable
5 Dextrans Not Applicable
6 Plasma Substitutes Not Applicable
7 Cola Nutraceutical
8 tyrosine Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preconditioning Shields Against Vascular Events in Surgery Unknown status NCT02097186 Not Applicable
2 Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum Unknown status NCT00534131 Not Applicable
3 Study of Ischemic Colitis Compared to Other Diagnoses in Patients With Lower Gastrointestinal Bleeding Completed NCT01078324
4 Preconditioning Shields Against Vascular Events in Surgery Completed NCT01691911 Not Applicable
5 Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery Completed NCT01404910 Not Applicable
6 Determination of the Aetiologies of Acute Colitis and Early Identification of Patients Requiring Diagnostic Colonoscopy Recruiting NCT02709213

Search NIH Clinical Center for Ischemic Colitis

Cochrane evidence based reviews: colitis, ischemic

Genetic Tests for Ischemic Colitis

Anatomical Context for Ischemic Colitis

MalaCards organs/tissues related to Ischemic Colitis:

41
Colon, Lung, Endothelial, Heart

Publications for Ischemic Colitis

Articles related to Ischemic Colitis:

(show top 50) (show all 132)
# Title Authors Year
1
Ischemic Colitis in Sickle Cell Disease: A Case Report of a Diagnostic Challenge. ( 29623225 )
2018
2
Ischemic colitis following left antegrade sclerotherapy for idiopathic varicocele. ( 29473213 )
2018
3
Gas In The Hepatic Portal Venous System Associated With Ischemic Colitis. ( 29880969 )
2018
4
Magnesium poisoning, multi-organ failure and ischemic colitis secondary to chronic ingestion of a parapharmacy product. ( 29667416 )
2018
5
Thumbprinting in Ischemic Colitis. ( 29897854 )
2018
6
'Runs' from a run: A case of exercise induced ischemic colitis. ( 29123610 )
2017
7
Predisposing Factors of Ischemic Colitis: Data from 14 Years of Experience in a Single Center. ( 28769977 )
2017
8
The incidence and outcome of ischemic colitis in a population-based setting. ( 28276832 )
2017
9
Association between lower air pressure and the onset of ischemic colitis: a case-control study. ( 28562393 )
2017
10
Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination. ( 28878651 )
2017
11
Severe Cytomegalovirus Infection Masquerading as Recurrent Ischemic Colitis in a Patient with End-Stage Renal Disease. ( 29299486 )
2017
12
The Incidence of Ischemic Colitis after Repair of Ruptured Abdominal Aortic Aneurysms is Decreasing in the Endovascular Era. ( 28919522 )
2017
13
Pemetrexed-associated Ischemic Colitis in Nonsmall Cell Lung Cancer. ( 28685736 )
2017
14
Fulminant gangrenous ischemic colitis: is it the solely severe type of ischemic colitis? ( 27838817 )
2017
15
Predictors of severity in ischemic colitis: Usefulness of early ultrasonography. ( 29103470 )
2017
16
Idiopathic Myointimal Hyperplasia of Mesenteric Veins: An Uncommon Cause of Ischemic Colitis With Distinct Mucosal Features. ( 28817406 )
2017
17
Cytomegalovirus: associated ischemic colitis in an immunocompetent patient. ( 28747055 )
2017
18
18F-FDG Uptake in Ischemic Colitis During Follow-up of a Patient With Lung Cancer. ( 28632689 )
2017
19
Predictive factors of mortality after colectomy in ischemic colitis: an ACS-NSQIP database study. ( 29766117 )
2017
20
Advents in the Diagnosis and Management of Ischemic Colitis. ( 28929100 )
2017
21
Pseudoephedrine Associated Ischemic Colitis. ( 28786857 )
2017
22
Ischemic colitis of the colon in streptozotocin-induced diabetic rats. ( 28780750 )
2017
23
Seasonal variation in occurrence of ischemic colitis: a retrospective study. ( 28222619 )
2017
24
Identification of the distinguishing features of Crohn's disease and ischemic colitis using computed tomographic enterography. ( 28852526 )
2017
25
Gastrointestinal: Phlebosclerotic colitis: A rare but increasingly recognized cause of ischemic colitis with telltale imaging features. ( 29024011 )
2017
26
Stercoral colitis complicated with ischemic colitis: a double-edge sword. ( 29179680 )
2017
27
Tubercular colitis masquerading as ischemic colitis: An unusual presentation. ( 29171457 )
2017
28
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. ( 26943694 )
2016
29
Ischemic colitis associated with acute carbon monoxide poisoning--a case report. ( 27265995 )
2016
30
Beyond Low Flow: How I Manage Ischemic Colitis. ( 27725651 )
2016
31
Anorexia nervosa hyperactivity-induced ischemic colitis (ANHIC): a new cause of anaemia. ( 27314583 )
2016
32
Severe ischemic colitis following olanzapine use - A case report. ( 26786111 )
2016
33
Ischemic Colitis as a Complication of Medication Use: An Analysis of the Federal Adverse Event Reporting System. ( 27073073 )
2016
34
Ischemic colitis following uncomplicated colonoscopy. ( 26751116 )
2016
35
Update on ischemic colitis: from etiopathology to treatment including patients of intensive care unit. ( 27152750 )
2016
36
A Rare Cause of Ischemic Colitis. ( 26972985 )
2016
37
Isolated naratriptan-associated ischemic colitis. ( 27695179 )
2016
38
Ischemic colitis as pseudocarcinoma: An unusual presentation. ( 27993411 )
2016
39
Ischemic colitis in an athlete: running is not always good for you. ( 27643713 )
2016
40
Arteriovenous malformation of the inferior mesenteric artery presenting as ischemic colitis. ( 27138349 )
2016
41
Amphetamine-related ischemic colitis causing gastrointestinal bleeding. ( 27365888 )
2016
42
Serum procalcitonin correlates with colonoscopy findings and can guide therapeutic decisions in postoperative ischemic colitis. ( 28089622 )
2016
43
A Rare Cause of Ischemic Colitis. ( 27018300 )
2016
44
Thoracic endovascular aortic repair for complicated chronic type B aortic dissection in a patient on hemodialysis with recurrent ischemic colitis. ( 27090121 )
2016
45
Risk factors and outcomes of postoperative ischemic colitis in contemporary open and endovascular abdominal aortic aneurysm repair. ( 26747680 )
2016
46
Ischemic Colitis after Cardiac Surgery: Can We Foresee the Threat? ( 27977704 )
2016
47
Poor prognostic factors in patients who underwent surgery for acute non-occlusive ischemic colitis. ( 25798186 )
2015
48
Antipsychotics-induced ischemic colitis: a case report. ( 25886897 )
2015
49
Sonographic and Endoscopic Findings in Cocaine-Induced Ischemic Colitis. ( 26798523 )
2015
50
Incidence of Ischemic Colitis in Treated, Commercially Insured Hypertensive Adults: A Cohort Study of US Health Claims Data. ( 25559045 )
2015

Variations for Ischemic Colitis

Expression for Ischemic Colitis

Search GEO for disease gene expression data for Ischemic Colitis.

Pathways for Ischemic Colitis

Pathways related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 APOH F2 F5 JAK2 SERPINC1
2
Show member pathways
12.5 F2 F5 MMP9 SERPINC1
3 12.48 HMOX1 JAK2 MMP2 MMP9
4
Show member pathways
12.31 F2 JAK2 MMP2
5
Show member pathways
12.25 JAK2 MMP2 MMP9
6
Show member pathways
11.87 F2 F5 SERPINC1
7 11.72 F2 F5 SERPINC1
8 11.69 HMOX1 MMP2 MMP9
9 11.45 HMOX1 MMP2 MMP9
10 11.27 MMP2 MMP9
11 11.25 JAK2 MMP2 MMP9
12
Show member pathways
11.23 MMP2 MMP9
13 11.13 HMOX1 MMP2 MMP9
14 11.07 MMP2 MMP9
15 11.05 F2 MMP9
16 10.98 HMOX1 JAK2 MMP2 MMP9
17 10.96 MMP2 MMP9
18 10.93 F2 MMP9
19 10.89 MMP2 MMP9
20 10.83 F2 MMP2
21 10.66 HMOX1 MMP2 MMP9

GO Terms for Ischemic Colitis

Cellular components related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 F2 F5 SERPINC1
2 extracellular region GO:0005576 9.43 APOH F2 F5 MMP2 MMP9 SERPINC1
3 extracellular matrix GO:0031012 9.33 APOH MMP2 MMP9
4 extracellular space GO:0005615 9.17 APOH F2 F5 HMOX1 MMP2 MMP9

Biological processes related to Ischemic Colitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 HMOX1 JAK2 MMP2 MMP9
2 cellular protein metabolic process GO:0044267 9.56 F2 F5 MMP2 SERPINC1
3 embryo implantation GO:0007566 9.54 MMP2 MMP9
4 cellular response to cadmium ion GO:0071276 9.52 HMOX1 MMP9
5 negative regulation of DNA binding GO:0043392 9.51 HMOX1 JAK2
6 hemostasis GO:0007599 9.5 F2 F5 SERPINC1
7 endodermal cell differentiation GO:0035987 9.49 MMP2 MMP9
8 positive regulation of DNA binding GO:0043388 9.48 JAK2 MMP9
9 blood coagulation, intrinsic pathway GO:0007597 9.46 APOH F2
10 blood coagulation GO:0007596 9.46 F2 F5 JAK2 SERPINC1
11 positive regulation of blood coagulation GO:0030194 9.43 APOH F2
12 negative regulation of fibrinolysis GO:0051918 9.4 APOH F2
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 JAK2 MMP2 MMP9
14 regulation of blood coagulation GO:0030193 8.8 APOH F2 SERPINC1

Molecular functions related to Ischemic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 MMP2 MMP9
2 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Ischemic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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