IHD
MCID: ISC006
MIFTS: 67

Ischemic Heart Disease (IHD)

Categories: Cardiovascular diseases

Aliases & Classifications for Ischemic Heart Disease

MalaCards integrated aliases for Ischemic Heart Disease:

Name: Ischemic Heart Disease 38
Ischemic Heart Disease, Susceptibility to 6
Coronary Arteriosclerosis 73
Myocardial Ischemia 73
Ihd 48

Classifications:



External Ids:

ICD10 33 I20-I25

Summaries for Ischemic Heart Disease

MalaCards based summary : Ischemic Heart Disease, also known as ischemic heart disease, susceptibility to, is related to kawasaki disease and coronary heart disease 1, and has symptoms including angina pectoris and other and unspecified angina pectoris. An important gene associated with Ischemic Heart Disease is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Lipoprotein metabolism. The drugs Angiotensin II and Olmesartan have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Ischemic Heart Disease

Diseases related to Ischemic Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)
# Related Disease Score Top Affiliating Genes
1 kawasaki disease 31.4 CCL2 CRP IL6 NPPB TNF
2 coronary heart disease 1 30.3 ACE APOA1 APOB APOE CRP F7
3 chlamydia 30.2 CRP IL6 TNF
4 heart disease 30.1 ACE APOA1 APOB APOE CRP F7
5 diabetes mellitus 30.0 ACE APOA1 APOB CRP IL6 LPL
6 takayasu arteritis 29.9 CRP IL6 TNF
7 diabetic foot ulcers 29.9 CCL2 IL6
8 spondylitis 29.8 CRP IL6 TNF
9 prediabetes syndrome 29.8 APOB CRP IL6
10 apnea, obstructive sleep 29.7 CRP IL6 TNF
11 multiple sclerosis 29.7 APOE CCL2 IL6 TNF
12 periodontitis 29.7 CCL2 CRP IL6 TNF
13 homocysteinemia 29.7 CRP MTHFR NOS3
14 peripheral vascular disease 29.7 ACE APOA1 APOB CRP IL6
15 acute myocardial infarction 29.7 ACE APOA1 APOB CRP NPPB
16 aortic valve disease 2 29.7 ACE CRP NPPB
17 angina pectoris 29.6 ACE CRP IL6 NOS3 NPPB
18 systolic heart failure 29.6 ACE CRP IL6 NPPB
19 maturity-onset diabetes of the young, type 1 29.6 ACE CRP IL6 TNF
20 hypercholesterolemia, familial 29.6 ACE APOA1 APOB APOE CRP LPL
21 cerebral atherosclerosis 29.6 ACE APOA1 APOE MTHFR
22 pulmonary disease, chronic obstructive 29.5 CCL2 CRP IL6 NPPB TNF
23 purpura 29.5 CRP IL6 TNF
24 coronary stenosis 29.5 ACE APOA1 APOB APOE CRP IL6
25 temporal arteritis 29.5 CCL2 CRP IL6 TNF
26 arteriosclerosis 29.5 ACE APOA1 APOB APOE CCL2 CRP
27 peripheral artery disease 29.5 ACE APOB CCL2 CRP IL6 NOS3
28 pneumonia 29.5 CCL2 CRP IL6 TNF
29 dilated cardiomyopathy 29.4 ACE CRP FHOD3 IL6 NOS3 NPPB
30 cytomegalovirus infection 29.4 CCL2 IL6 TNF
31 sleep apnea 29.4 ACE APOE CRP IL6 NOS3 NPPB
32 aortic aneurysm, familial abdominal, 1 29.4 ACE APOE CCL2 CRP IL6
33 lipid metabolism disorder 29.4 ACE APOA1 APOB APOE CRP LPL
34 lung disease 29.3 CCL2 IL6 NPPB TNF
35 coronary artery anomaly 29.3 ACE APOA1 APOB CRP F7 LPL
36 stroke, ischemic 29.2 ACE APOB APOE CRP F7 MTHFR
37 cerebrovascular disease 29.2 ACE APOA1 APOB APOE CRP F7
38 hypertension, essential 29.1 ACE APOA1 APOB CRP LPL NOS3
39 kidney disease 29.1 ACE APOE CCL2 CRP IL6 NOS3
40 carotid stenosis 29.1 ACE APOE CRP F7 MTHFR TNF
41 chronic kidney failure 29.0 ACE APOB CRP IL6 MTHFR NOS3
42 arteries, anomalies of 29.0 ACE APOA1 APOB APOE CCL2 CRP
43 diabetes mellitus, noninsulin-dependent 28.9 ACE APOA1 APOB APOE CCL2 CRP
44 vascular disease 28.8 ACE APOA1 APOB APOE CCL2 CRP
45 myocardial infarction 28.7 ACE APOA1 APOB APOE CCL2 CRP
46 sick sinus syndrome 11.0
47 ischemia 10.4
48 vaccinia 10.4
49 depression 10.3
50 renal artery disease 10.3 ACE NOS3

Comorbidity relations with Ischemic Heart Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 201)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Anterolateral Myocardial Infarction Acute Apical Periodontitis
Acute Conjunctivitis Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Myocarditis
Acute Pancreatitis Acute Stress Disorder
Acute Vascular Insufficiency of Intestine Adjustment Disorder
Alcoholic Cardiomyopathy Allergic Urticaria
Angina Pectoris Anthracosis
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Aortic Valve Disease 2 Aortic Valve Insufficiency
Asbestosis Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autonomic Nervous System Disease Bacteremia 2
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Hypertensive Renal Disease Benign Renovascular Hypertension
Bicipital Tenosynovitis Bladder Cancer
Bleeding Disorder, Platelet-Type, 11 Blepharoconjunctivitis
Bronchitis Bronchopneumonia
Buerger Disease Cardiac Arrest
Cardiac Arrhythmia Cardiogenic Shock
Central Nervous System Origin Vertigo Central Retinal Artery Occlusion
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Cholecystitis

Graphical network of the top 20 diseases related to Ischemic Heart Disease:



Diseases related to Ischemic Heart Disease

Symptoms & Phenotypes for Ischemic Heart Disease

UMLS symptoms related to Ischemic Heart Disease:


angina pectoris, other and unspecified angina pectoris

GenomeRNAi Phenotypes related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE LPL
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LPL

MGI Mouse Phenotypes related to Ischemic Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ACE APOA1 APOB APOE CRP F7
2 homeostasis/metabolism MP:0005376 10.03 ACE APOA1 APOB APOE CRP F7
3 growth/size/body region MP:0005378 10.02 ACE APOB APOE F7 FHOD3 IL6
4 adipose tissue MP:0005375 9.95 ACE APOE F7 IL6 LPL NOS3
5 liver/biliary system MP:0005370 9.81 ACE APOA1 APOB APOE IL6 LPL
6 mortality/aging MP:0010768 9.65 ACE APOB APOE F7 FHOD3 IL6
7 muscle MP:0005369 9.17 APOB APOE FHOD3 IL6 LPL NOS3

Drugs & Therapeutics for Ischemic Heart Disease

Drugs for Ischemic Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1099)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
2
Olmesartan Approved, Investigational Phase 4,Phase 2 144689-63-4, 144689-24-7 158781 130881
3
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 159351-69-6 6442177
4
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53123-88-9 46835353 6436030 5284616
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
6
Ticagrelor Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 274693-27-5 9871419
7
Clopidogrel Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113665-84-2, 120202-66-6 60606
8
Ticlopidine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55142-85-3 5472
9
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 73963-72-1 2754
10 Nutmeg Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 142387-99-3, 95635-55-5 56959
12
Tirofiban Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 144494-65-5 60947
13
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
14
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55-56-1 2713 9552079
15
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 79902-63-9 54454
16
Trimetazidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 5011-34-7
17
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
18
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6
19
Insulin Glargine Approved Phase 4,Phase 3 160337-95-1
20
Acarbose Approved, Investigational Phase 4,Phase 3,Not Applicable 56180-94-0 441184
21
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128270-60-0 16129704
22
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 88150-42-9 2162
23
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
24
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 111025-46-8 4829
25
Warfarin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81-81-2 6691 54678486
26
Rivaroxaban Approved Phase 4,Phase 3,Phase 2 366789-02-8
27
Chromium Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-47-3 27668
28
Cobalt Approved, Experimental Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-48-4 104729
29
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
30
Pitavastatin Approved Phase 4,Phase 3,Not Applicable 147511-69-1, 147526-32-7 5282452 6366718
31
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 122320-73-4 77999
32
Glyburide Approved Phase 4,Phase 3,Phase 1,Not Applicable 10238-21-8 3488
33
Fluvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 93957-54-1 1548972
34
Lovastatin Approved, Investigational Phase 4,Phase 2,Phase 3 75330-75-5 53232
35
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 163222-33-1 150311
36
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1406-66-2 14986
37
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 3416-24-8 439213
38
Carvedilol Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 72956-09-3 2585
39
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-61-7 60961
40
Vorapaxar Approved Phase 4,Phase 3,Phase 2,Phase 1 618385-01-6
41
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable
42
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
43
Regadenoson Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 313348-27-5 219024
44
Dipyridamole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-32-2 3108
45
Enoxaparin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772
46
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 98-92-0 936
47
Nicorandil Approved, Investigational Phase 4,Phase 3,Not Applicable 65141-46-0 47528
48 tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
49
Etomidate Approved Phase 4 33125-97-2 667484 36339
50
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273

Interventional clinical trials:

(show top 50) (show all 8012)
# Name Status NCT ID Phase Drugs
1 Efficacy Study of Olmesartan Medoxomil on Coronary Atherosclerosis and Epicardial Adipose Tissue(EAT) Unknown status NCT02360956 Phase 4 Olmesartan medoxomil tablets;Antihypertensive medication (per doctor suggestion)
2 The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients With Coronary Artery Disease Unknown status NCT01508663 Phase 4 ARB, CCB, ACE-inhibitor, statin, Nitrate, Antiplate etc.
3 Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
4 Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease Unknown status NCT02514642 Phase 4 low-dose ticagrelor;Clopidogrel
5 Rosuvastatin Effect on Reducing Coronary Atherosclerosis Plaques Volume Unknown status NCT01382277 Phase 4 Rosuvastatin
6 A Trial to Evaluate Efficacy of Heart-protecting Musk Pill Unknown status NCT01897805 Phase 4 Heart-protecting Musk Pill;Placebo
7 Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo
8 Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function Unknown status NCT01825759 Phase 4 danshen dripping pill
9 The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques Unknown status NCT01773512 Phase 4 Rosuvastatin
10 The Association Between Very Small Embryonic-like Stem Cells and the Prognosis of Coronary Artery Disease Patients Unknown status NCT01633359 Phase 4 Intensive statin;Routine statin
11 Ranolazine for Improving Symptoms of Palpitations Unknown status NCT01495520 Phase 4 Ranolazine;Placebo
12 Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
13 Firebird 2 Versus Excel Sirolimus-eluting Stent in Treating Real-world Patients With Coronary Artery Disease Unknown status NCT01373632 Phase 4
14 Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa) Unknown status NCT02030054 Phase 4 Atorvastatin;Rosuvastatin
15 Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
16 Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients Unknown status NCT02001883 Phase 4 Association low-dose statin and nutraceuticals
17 The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease Unknown status NCT02107144 Phase 4 trimetazidine
18 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
19 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Unknown status NCT02457130 Phase 4 Ticagrelor;Clopidogrel
20 Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial) Unknown status NCT00858676 Phase 4 acarbose
21 Bivalirudin in Stable Ischemic Heart Disease Patients Undergoing PCI Unknown status NCT02787317 Phase 4 bivalirudin;Heparin
22 Comparison of Biomatrix and Orsiro Drug Eluting Stent Unknown status NCT02299011 Phase 4 Biomatrix drug eluting stent
23 Xience/Promus for Long Coronary Lesion Registry Unknown status NCT01147237 Phase 4
24 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
25 A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer SES Safety and Effectiveness in CAD Treatment Unknown status NCT01880879 Phase 4
26 Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity Unknown status NCT01567774 Phase 4 Atorvastatin;Rosuvastatin
27 The Effect of Tongguan Capsule for MicroRNA Profiles in Coronary Heart Disease Patients Unknown status NCT02850627 Phase 4 Tongguan capsule;placebo capsule
28 Pharmacodynamic Effects of Ranolazine Versus Amlodipine on Platelet Reactivity Unknown status NCT01490255 Phase 4 Ranolazine;Amlodipine
29 Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients Unknown status NCT00155350 Phase 4 pioglitazone
30 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
31 Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study Unknown status NCT02642419 Phase 4 Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
32 Safety and Effectiveness of the Coronary Momo Stent Unknown status NCT01535625 Phase 4
33 Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate Injection Unknown status NCT02694848 Phase 4 Salvianolate injection;Aspirin
34 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
35 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
36 Ranolazine, Ethnicity and the Metabolic Syndrome Unknown status NCT01304095 Phase 4 Ranolazine
37 Assessment of Surface Coverage of Two Types of DES in Diabetes Mellitus and Non- Diabetes Mellitus Unknown status NCT01023919 Phase 4
38 Overcoming High On-Treatment Platelet Reactivity (HPR) During Prasugrel Therapy With Ticagrelor Unknown status NCT01869309 Phase 4 Prasugrel;Ticagrelor
39 PharmacOdynamic compaRison of piTavastatin Versus atOrvastatin on Platelet Reactivity Unknown status NCT01648829 Phase 4 Atorvastatin;Pitavastatin
40 Multivessel Stenting Versus Staged Revascularization With Zotarolimus-eluting Stent for STEMI Unknown status NCT01781715 Phase 4
41 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
42 Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery Unknown status NCT02919345 Phase 4 Dapagliflozin 10 mg;Glibenclamide 5 mg
43 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
44 Cholesterol-lowering Effects of nutraceuticaLs Versus Ezetimibe in Statin-intolerant Patients Unknown status NCT01807078 Phase 4 Ezetimibe
45 Diagnostic Benefits of HyperQTM vs. Conventional ECG Stress Test. Comparison of HyperQ vs. Stress ECG in Women Before Angiography Unknown status NCT00850486 Phase 4
46 Prospective Multicenter Registry of Hybrid Coronary Artery Revascularization Combined With Surgical Bypass and Percutaneous Coronary Intervention Using Everolimus Eluting Metallic Stents Unknown status NCT02894255 Phase 4
47 Comparison of Biolimus-eluting Biodegradable Polymer, Everolimus-eluting and Sirolimus-eluting Coronary Stents Unknown status NCT01268371 Phase 4
48 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
49 A Registry To Evaluate Safety And Effectiveness Of Everolimus Drug Eluting Stent For Coronary Revascularization Unknown status NCT01157455 Phase 4 Aspirin;Clopidogrel;Heparin or Bivalirudin
50 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4

Search NIH Clinical Center for Ischemic Heart Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Heart Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Heart Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell�, adipose-derived stem cells for chronic ischemic cardiomyopathy
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived mesenchymal stem cells for treatment of ischemic cardiomyopathy during artery bypass grafting
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell�, bone marrow-derived mesenchymal stem cells for heart diseases
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
itMSC, bone marrow-derived mesenchymal stem cells for cardiovascular diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM�, mesenchymal stem cells for ischemic cardiomyopathy
Embryonic/Adult Cultured Cells Related to Ischemic Heart Disease:
Bone marrow-derived CD34+ stem cells (ACT34) PMIDs: 11283669 12551872 22163120 20448213 9020076 17562958 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cells PMIDs: 21082397 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family) PMIDs: 21052537 19591227
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells PMIDs: 22940024 21392602
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mononuclear cells (family) PMIDs: 21392602 22940024
Porcine bone marrow-derived mesenchymal stem cells PMIDs: 21392602 22940024
Human cardiac stem cells PMIDs: 22088800 22965994
Cardiomyocyte-like cells PMIDs: 18941512
Bone marrow-derived progenitor cells PMIDs: 23362308 22936827 18794392 16990384 16990385 22651868
Bone marrow-derived mononuclear cells PMIDs: 21323410 20631864
Bone marrow-derived mesenchymal stem cells PMIDs: 21323410 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells PMIDs: 20668107 21596713 19761394 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel�) PMIDs: 18720444

Genetic Tests for Ischemic Heart Disease

Anatomical Context for Ischemic Heart Disease

MalaCards organs/tissues related to Ischemic Heart Disease:

41
Heart, Bone, Endothelial, Bone Marrow, Testes, Lung, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Ischemic Heart Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Limb Pelvic Girdle Bone Marrow Stromal Cells Potential therapeutic candidate
2 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Ischemic Heart Disease

Articles related to Ischemic Heart Disease:

(show top 50) (show all 1760)
# Title Authors Year
1
Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know. ( 28606397 )
2019
2
Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease. ( 29343820 )
2018
3
Coagulation Factors in Ischemic Heart Disease: Answers From a Mendelian Randomization Study Inspire Further Questions. ( 29874185 )
2018
4
Out-of-Hospital Cardiac Arrest in the Presence of Ischemic Heart Disease: What Is the Long-term Arrhythmic Risk After Revascularization? ( 29958725 )
2018
5
Coagulation Factors and the Risk of Ischemic Heart Disease: A Mendelian Randomization Study. ( 29874180 )
2018
6
Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. ( 29850230 )
2018
7
Disconnect Between Genes Associated With Ischemic Heart Disease and Targets of Ischemic Heart Disease Treatments. ( 29396305 )
2018
8
Spontaneously occurring intramural coronary arteriosclerosis in regularly slaughtered veal calves and beef cattle: aA screening study about prevalence and histopathological features. ( 29371083 )
2018
9
Association between unplanned readmission to a different hospital and all-cause mortality among older patients with ischemic heart disease: A nationwide claim study. ( 29371060 )
2018
10
Cerebral Protection During Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Heart Disease. ( 29960991 )
2018
11
Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: The Headache of Nonevidence-Based Medicine for Ischemic Heart Disease? ( 29413373 )
2018
12
Effect of Baseline Antiarrhythmic Drug on Outcomes With Ablation in Ischemic Ventricular Tachycardia: A VANISH Substudy (Ventricular Tachycardia Ablation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease). ( 29305400 )
2018
13
Loss-Framed Financial Incentives and Personalized Goal-Setting to Increase Physical Activity Among Ischemic Heart Disease Patients Using Wearable Devices: The ACTIVE REWARD Randomized Trial. ( 29899015 )
2018
14
Pronounced Coronary Arteriosclerosis in Cirrhosis: Influence on Cardiac Function and Survival? ( 29516327 )
2018
15
Concurrent renal dysfunction with ischemic heart disease is an important determinant for cardiac and cerebrovascular mortality in patients on chronic digoxin therapy for atrial fibrillation. ( 29971208 )
2018
16
The effect of exercise therapy on depressive and anxious symptoms in patients with ischemic heart disease: A systematic review. ( 29332638 )
2018
17
Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study. ( 29337985 )
2018
18
Loss-Framed Financial Incentives With a Wearable Device for Secondary Prevention of Ischemic Heart Disease: Stepping Up to the Challenge? ( 29899016 )
2018
19
Prevalence of Takayasu arteritis in young women with acute ischemic heart disease. ( 29249430 )
2018
20
Relationships between road-distance to primary care facilities and ischemic heart disease and stroke mortality in Hokkaido, Japan: A Bayesian hierarchical approach to ecological count data. ( 29340259 )
2018
21
The association between the serum level of vitamin D and ischemic heart disease: a study from Jordan. ( 29928126 )
2018
22
Outcomes of Care for Ischemic Heart Disease and Chronic Heart Failure in the Veterans Health Administration. ( 29800040 )
2018
23
Optimal Guideline-Directed Medical Therapy for Patients With Stable Ischemic Heart Disease. ( 29903358 )
2018
24
Long-term projections of temperature-related mortality risks for ischemic stroke, hemorrhagic stroke, and acute ischemic heart disease under changing climate in Beijing, China. ( 29241068 )
2018
25
Corrigendum to "Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery" [Med. Hypotheses 104 (2017) 20-24]. ( 29406994 )
2018
26
Hybrid Imaging in Ischemic Heart Disease. ( 29329818 )
2018
27
Coronary Microcirculation in Ischemic Heart Disease. ( 29938611 )
2018
28
Is defibrillator less useful in patients with non-ischemic heart disease? ( 29798811 )
2018
29
Progression of diabetes, ischemic heart disease, and chronic kidney disease in a three chronic conditions multistate model. ( 29914451 )
2018
30
Sex Differences in Ischemic Heart Disease: Advances, Obstacles, and Next Steps. ( 29449443 )
2018
31
Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ. ( 29730730 )
2018
32
Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease. ( 29403392 )
2018
33
Nocturnal hypoventilation may have a protective effect for Ischemic heart disease in Obesity Hypoventilation Syndrome. ( 29911492 )
2018
34
The Role of 27 Human Gut Microbiota Genera in Ischemic Heart Disease, Type 2 Diabetes Mellitus and Their Risk Factors: A Mendelian Randomization Study. ( 29800124 )
2018
35
Chronic Ischemic Heart Disease, Selection of Treatment Modality ( 29939525 )
2018
36
A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain. ( 29351337 )
2018
37
Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond. ( 29963220 )
2018
38
Reply: Optimal Guideline-Directed Medical Therapy for Patients With Stable Ischemic Heart Disease. ( 29903359 )
2018
39
Favorable effects of statins in the treatment of heart failure with preserved ejection fraction in patients without ischemic heart disease. ( 29307549 )
2018
40
Epistasis analysis of metabolic genes polymorphisms associated with ischemic heart disease in Yucatan. ( 29395491 )
2018
41
Impact  of an integral assistance model between primary care and cardiology on the management of patients with ischemic heart disease or atrial fibrillation. ( 30547674 )
2018
42
Improving Medical Attention Through an Integral Care Model for Patients With Ischemic Heart Disease or Atrial Fibrillation. ( 30497946 )
2018
43
Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction. ( 30371286 )
2018
44
Severity of ischemic heart disease and presenting rhythm in patients with out-of-hospital cardiac arrest. ( 30031785 )
2018
45
Coronary stenosis and left ventricular function - Major prognostic factors in patients with ischemic heart disease: Has something changed in the era of "precision medicine"? ( 30545618 )
2018
46
Average Clinician-Measured Blood Pressures and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Ischemic Heart Disease in the EXAMINE Trial. ( 30371278 )
2018
47
Diesel exhaust, respirable dust, and ischemic heart disease: an application of the parametric g-formula. ( 30489348 )
2018
48
Dual antiplatelet therapy versus aspirin monotherapy in diabetics with stable ischemic heart disease undergoing coronary artery bypass grafting. ( 30505747 )
2018
49
Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design. ( 30511337 )
2018
50
Case 6 - Woman with Ischemic Heart Disease Admitted due to Chest Pain and Shock. ( 30517382 )
2018

Variations for Ischemic Heart Disease

ClinVar genetic disease variations for Ischemic Heart Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NOS3 NM_000603.4(NOS3): c.894T> G (p.Asp298Glu) single nucleotide variant Benign rs1799983 GRCh37 Chromosome 7, 150696111: 150696111
2 NOS3 NM_000603.4(NOS3): c.894T> G (p.Asp298Glu) single nucleotide variant Benign rs1799983 GRCh38 Chromosome 7, 150999023: 150999023

Expression for Ischemic Heart Disease

LifeMap Discovery
Genes differentially expressed in tissues of Ischemic Heart Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 EIF1AY eukaryotic translation initiation factor 1A, Y-linked Heart + 3.61 0.020
2 LEP leptin Heart + 3.55 0.003
3 MFSD4 major facilitator superfamily domain containing 4 Endothelium + 3.54 0.000
4 FOSB FBJ murine osteosarcoma viral oncogene homolog B Heart + 3.13 0.012
5 DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked Heart + 3.12 0.017
6 RBP4 retinol binding protein 4, plasma Heart + 3.11 0.011
Search GEO for disease gene expression data for Ischemic Heart Disease.

Pathways for Ischemic Heart Disease

Pathways related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 APOA1 APOB APOE LPL MTHFR
2
Show member pathways
12.44 APOA1 APOB APOE LPL
3
Show member pathways
12.43 CCL2 IL6 NOS3 TNF
4
Show member pathways
12.17 APOA1 APOB APOE LPL
5 11.95 CCL2 NOS3 TNF
6 11.92 IL6 LPL TNF
7 11.88 CCL2 IL6 TNF
8 11.84 CCL2 IL6 TNF
9 11.81 CCL2 IL6 TNF
10
Show member pathways
11.8 IL6 NOS3 TNF
11
Show member pathways
11.77 APOA1 APOB APOE
12 11.7 CCL2 IL6 TNF
13
Show member pathways
11.63 APOA1 APOB APOE LPL
14
Show member pathways
11.61 APOA1 APOB APOE CCL2 CRP F7
15 11.59 CCL2 IL6 TNF
16 11.52 CCL2 IL6 TNF
17 11.45 CCL2 IL6 NOS3 TNF
18 11.39 CCL2 IL6 TNF
19 11.38 CCL2 IL6 TNF
20 11.35 APOB IL6 TNF
21 11.31 APOE IL6 TNF
22 11.15 APOA1 IL6 TNF
23 11.11 CCL2 IL6 NOS3
24 11.05 ACE APOE CCL2
25 10.99 IL6 MTHFR TNF
26 10.82 CCL2 TNF
27 10.41 CRP IL6 TNF

GO Terms for Ischemic Heart Disease

Cellular components related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.83 APOA1 APOB APOE F7 IL6
2 endocytic vesicle lumen GO:0071682 9.58 APOA1 APOB APOE
3 low-density lipoprotein particle GO:0034362 9.54 APOA1 APOB APOE
4 intermediate-density lipoprotein particle GO:0034363 9.5 APOA1 APOB APOE
5 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
6 very-low-density lipoprotein particle GO:0034361 9.46 APOA1 APOB APOE LPL
7 extracellular space GO:0005615 9.36 ACE APOA1 APOB APOE CCL2 CRP
8 chylomicron GO:0042627 9.26 APOA1 APOB APOE LPL
9 extracellular region GO:0005576 10 ACE APOA1 APOB APOE CCL2 CRP

Biological processes related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.98 APOA1 APOB APOE IL6
2 positive regulation of gene expression GO:0010628 9.92 APOB CRP IL6 NOS3 TNF
3 lipid transport GO:0006869 9.88 APOA1 APOB APOE
4 steroid metabolic process GO:0008202 9.86 APOA1 APOB APOE
5 cellular protein metabolic process GO:0044267 9.86 APOA1 APOB APOE IL6
6 defense response to Gram-positive bacterium GO:0050830 9.83 CRP IL6 TNF
7 cholesterol metabolic process GO:0008203 9.82 APOA1 APOB APOE
8 regulation of blood pressure GO:0008217 9.77 ACE NOS3 NPPB
9 humoral immune response GO:0006959 9.72 CCL2 IL6 TNF
10 positive regulation of chemokine production GO:0032722 9.71 IL6 TNF
11 vasodilation GO:0042311 9.71 APOE NOS3
12 retinoid metabolic process GO:0001523 9.71 APOA1 APOB APOE
13 cholesterol homeostasis GO:0042632 9.71 APOA1 APOB APOE LPL
14 nitric oxide mediated signal transduction GO:0007263 9.7 APOE NOS3
15 regulation of blood vessel size GO:0050880 9.7 NOS3 NPPB
16 reverse cholesterol transport GO:0043691 9.7 APOA1 APOE
17 high-density lipoprotein particle remodeling GO:0034375 9.69 APOA1 APOE
18 positive regulation of glial cell proliferation GO:0060252 9.69 IL6 TNF
19 positive regulation of lipid biosynthetic process GO:0046889 9.69 APOA1 APOE
20 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.68 APOB LPL
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 APOE TNF
22 low-density lipoprotein particle remodeling GO:0034374 9.67 APOB APOE
23 regulation of blood vessel diameter GO:0097746 9.67 ACE NPPB
24 high-density lipoprotein particle assembly GO:0034380 9.67 APOA1 APOE
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 NOS3 TNF
26 phospholipid efflux GO:0033700 9.66 APOA1 APOE
27 positive regulation of chemokine secretion GO:0090197 9.65 LPL TNF
28 positive regulation of leukocyte chemotaxis GO:0002690 9.65 F7 IL6
29 triglyceride homeostasis GO:0070328 9.65 APOA1 APOE LPL
30 high-density lipoprotein particle clearance GO:0034384 9.64 APOA1 APOE
31 negative regulation of platelet activation GO:0010544 9.64 APOE NOS3
32 positive regulation of cholesterol esterification GO:0010873 9.63 APOA1 APOE
33 chylomicron remnant clearance GO:0034382 9.63 APOB APOE
34 cholesterol efflux GO:0033344 9.63 APOA1 APOB APOE
35 neutrophil mediated immunity GO:0002446 9.62 ACE IL6
36 negative regulation of hydrolase activity GO:0051346 9.62 APOA1 NOS3
37 positive regulation of cholesterol storage GO:0010886 9.61 APOB LPL
38 regulation of Cdc42 protein signal transduction GO:0032489 9.61 APOA1 APOE
39 lipoprotein metabolic process GO:0042157 9.61 APOA1 APOB APOE
40 regulation of cholesterol transport GO:0032374 9.6 APOA1 APOE
41 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 APOA1 TNF
42 positive regulation of neuroinflammatory response GO:0150078 9.58 IL6 TNF
43 very-low-density lipoprotein particle clearance GO:0034447 9.57 APOB APOE
44 chylomicron assembly GO:0034378 9.54 APOA1 APOB APOE
45 lipoprotein catabolic process GO:0042159 9.51 APOB APOE
46 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
47 very-low-density lipoprotein particle remodeling GO:0034372 9.43 APOA1 APOE LPL
48 lipoprotein biosynthetic process GO:0042158 9.33 APOA1 APOB APOE
49 triglyceride catabolic process GO:0019433 9.26 APOA1 APOB APOE LPL
50 chylomicron remodeling GO:0034371 8.92 APOA1 APOB APOE LPL

Molecular functions related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.71 CCL2 F7 LPL NPPB
2 phospholipid binding GO:0005543 9.54 APOA1 APOB APOE
3 lipid transporter activity GO:0005319 9.33 APOA1 APOB APOE
4 lipoprotein particle binding GO:0071813 9.32 APOA1 APOE
5 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.26 APOA1 APOE
6 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CRP
7 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE

Sources for Ischemic Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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