MCID: ISC006
MIFTS: 72

Ischemic Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Ischemic Heart Disease

MalaCards integrated aliases for Ischemic Heart Disease:

Name: Ischemic Heart Disease 38
Ischemic Heart Disease, Susceptibility to 6
Coronary Arteriosclerosis 73
Myocardial Ischemia 73

Classifications:



External Ids:

ICD10 33 I20-I25

Summaries for Ischemic Heart Disease

MalaCards based summary : Ischemic Heart Disease, also known as ischemic heart disease, susceptibility to, is related to kawasaki disease and cerebral atherosclerosis, and has symptoms including angina pectoris and other and unspecified angina pectoris. An important gene associated with Ischemic Heart Disease is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Lipoprotein metabolism. The drugs Zinc and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Ischemic Heart Disease

Diseases related to Ischemic Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 306)
# Related Disease Score Top Affiliating Genes
1 kawasaki disease 31.4 CRP IL6 NPPB TNF
2 cerebral atherosclerosis 30.2 ACE APOA1 APOE
3 chlamydia 30.1 CRP IL6 TNF
4 microvascular complications of diabetes 5 30.1 ACE INS NOS3
5 aortic valve disease 2 30.1 ACE CRP NPPB
6 periodontitis 30.0 CRP IL6 TNF
7 angina pectoris 30.0 ACE CRP IL6 NOS3
8 pneumonia 30.0 CRP IL6 TNF
9 hyperuricemia 30.0 APOB CRP INS
10 brucellosis 29.9 CRP IL6 TNF
11 takayasu arteritis 29.9 CRP IL6 TNF
12 spondylitis 29.9 CRP IL6 TNF
13 acute myocardial infarction 29.6 ACE APOA1 CRP NPPB
14 apnea, obstructive sleep 29.5 CRP IL6 INS TNF
15 homocysteinemia 29.4 CRP F2 NOS3
16 coronary heart disease 1 29.0 ACE APOA1 APOB APOE CRP F7
17 systolic heart failure 28.9 ACE CRP IL6 NPPB TNF
18 coronary stenosis 28.8 ACE APOA1 APOB APOE CRP IL6
19 kidney disease 28.7 ACE APOE CRP INS NPPB
20 osteoporosis 28.7 APOE CRP IL6 INS TNF
21 carotid stenosis 28.7 ACE APOE CRP F7 TNF
22 chronic kidney failure 28.6 ACE CRP IL6 INS NPPB
23 peritonitis 28.5 CRP F2 IL6 TNF
24 arteriosclerosis 28.1 ACE APOA1 APOB APOE CRP IL6
25 dilated cardiomyopathy 28.0 ACE CRP FHOD3 IL6 NOS3 NPPB
26 diabetes mellitus 27.9 ACE APOA1 APOB CRP IL6 INS
27 hypercholesterolemia, familial 27.8 APOA1 APOB APOE CRP INS LPL
28 lipid metabolism disorder 27.8 ACE APOA1 APOB APOE CRP INS
29 peripheral vascular disease 27.8 ACE APOA1 APOB CRP F2 IL6
30 sleep apnea 27.3 ACE APOE CRP IL6 INS NOS3
31 hypertension, essential 27.2 ACE APOA1 APOB CRP INS LPL
32 stroke, ischemic 26.9 ACE APOB APOE CRP F2 F7
33 diabetes mellitus, noninsulin-dependent 25.3 ACE APOA1 APOB APOE CRP F7
34 coronary artery anomaly 25.1 ACE APOA1 APOB APOE CRP F7
35 cerebrovascular disease 25.0 ACE APOA1 APOB APOE CRP F2
36 heart disease 24.7 ACE APOA1 APOB APOE CRP F2
37 vascular disease 24.7 ACE APOA1 APOB APOE CRP F2
38 arteries, anomalies of 24.6 ACE APOA1 APOB APOE CRP F2
39 myocardial infarction 24.0 ACE APOA1 APOB APOE CRP F2
40 moderate and severe traumatic brain injury 10.9 ACE APOE
41 sick sinus syndrome 10.9
42 intracranial vasospasm 10.8 APOE NOS3
43 xanthoma disseminatum 10.8 APOB APOE
44 hypercholesterolemia, autosomal dominant, type b 10.7 APOB APOE
45 renal artery disease 10.7 ACE NOS3
46 familial lcat deficiency 10.7 APOA1 APOE
47 cold agglutinin disease 10.7 CRP IL6
48 defective apolipoprotein b-100 10.7 APOB APOE
49 subacute cutaneous lupus erythematosus 10.7 ACE TNF
50 skin sarcoidosis 10.7 ACE TNF

Comorbidity relations with Ischemic Heart Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 202)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Anterolateral Myocardial Infarction Acute Apical Periodontitis
Acute Conjunctivitis Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Myocarditis
Acute Pancreatitis Acute Stress Disorder
Acute Vascular Insufficiency of Intestine Adjustment Disorder
Alcoholic Cardiomyopathy Allergic Urticaria
Angina Pectoris Anthracosis
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Aortic Valve Disease 2 Aortic Valve Insufficiency
Asbestosis Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autonomic Nervous System Disease Bacteremia 2
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Hypertensive Renal Disease Benign Renovascular Hypertension
Bicipital Tenosynovitis Bladder Cancer
Bleeding Disorder, Platelet-Type, 11 Blepharoconjunctivitis
Bronchitis Bronchopneumonia
Buerger Disease Cardiac Arrest
Cardiac Arrhythmia Cardiogenic Shock
Central Nervous System Origin Vertigo Central Retinal Artery Occlusion
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Cholecystitis

Graphical network of the top 20 diseases related to Ischemic Heart Disease:



Diseases related to Ischemic Heart Disease

Symptoms & Phenotypes for Ischemic Heart Disease

UMLS symptoms related to Ischemic Heart Disease:


angina pectoris, other and unspecified angina pectoris

GenomeRNAi Phenotypes related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE LPL
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LPL

MGI Mouse Phenotypes related to Ischemic Heart Disease:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 FHOD3 APOE IL6 ACE CRP F2
2 homeostasis/metabolism MP:0005376 10.25 FHOD3 APOE IL6 ACE CRP F2
3 growth/size/body region MP:0005378 10.2 APOB F7 FHOD3 APOE ACE F2
4 adipose tissue MP:0005375 10.1 APOE IL6 ACE F7 LPL NOS3
5 immune system MP:0005387 10.06 APOB APOE CRP ACE F2 IL6
6 mortality/aging MP:0010768 10 APOB F7 FHOD3 APOE ACE F2
7 liver/biliary system MP:0005370 9.97 APOE IL6 ACE APOA1 APOB LPL
8 integument MP:0010771 9.91 APOE APOA1 F2 TNF LPL IL6
9 muscle MP:0005369 9.76 FHOD3 APOE APOB LPL IL6 NOS3
10 reproductive system MP:0005389 9.56 APOB APOE ACE F2 IL6 NOS3
11 respiratory system MP:0005388 9.1 APOE F2 TNF LPL IL6 NOS3

Drugs & Therapeutics for Ischemic Heart Disease

Drugs for Ischemic Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1068)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 23994
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 137-58-6 3676
3
Tirofiban Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 144494-65-5 60947
4
Spironolactone Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 1952-01-7, 52-01-7 5833
5
Ticlopidine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55142-85-3 5472
6
Etomidate Approved Phase 4 33125-97-2 36339 667484
7
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 141758-74-9 15991534
8
Clopidogrel Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606
9
Lenograstim Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 135968-09-1
10
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 54-31-9 3440
11
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 111025-46-8 4829
12
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 2216-51-5 16666
13
Nicotine Approved Phase 4,Phase 3,Phase 2,Not Applicable 54-11-5 942 89594
14
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 88150-42-9 2162
15
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 79902-63-9 54454
16
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
17
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-23-7 5754
18
Amiloride Approved Phase 4,Phase 2,Phase 3,Not Applicable 2016-88-8, 2609-46-3 16231
19
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28523-86-6 5206
20
Varenicline Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 249296-44-4 5310966
21
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 142387-99-3, 95635-55-5 56959
22
Warfarin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81-81-2 6691 54678486
23
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
24
Losartan Approved Phase 4,Early Phase 1 114798-26-4 3961
25
Ramipril Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 87333-19-5 5362129
26
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 163222-33-1 150311
27
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
28
Doxazosin Approved Phase 4,Phase 3,Not Applicable 74191-85-8 3157
29
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
30
Allopurinol Approved Phase 4,Phase 3,Not Applicable 315-30-0 2094
31
Phenprocoumon Approved, Investigational Phase 4 435-97-2 9908 54680692
32
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-61-6, 62-31-7 681
33
Nifedipine Approved Phase 4,Phase 3,Not Applicable 21829-25-4 4485
34 Trapidil Approved Phase 4 15421-84-8
35
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 137862-53-4 60846
36
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
37
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
38
Dobutamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 34368-04-2 36811
39
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2,Not Applicable 13422-51-0 11953898 44475014
40
Acetylcholine Approved Phase 4,Phase 2,Phase 1,Not Applicable 51-84-3 187
41
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
42
Pantoprazole Approved Phase 4,Phase 3,Phase 1,Not Applicable 102625-70-7 4679
43
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 58-93-5 3639
44
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
45
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
46
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-41-2 439260
47
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
48 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
49
Amiodarone Approved, Investigational Phase 4,Phase 3,Early Phase 1,Not Applicable 1951-25-3 2157
50
Abciximab Approved Phase 4,Phase 3,Phase 2,Not Applicable 143653-53-6

Interventional clinical trials:

(show top 50) (show all 7610)
# Name Status NCT ID Phase Drugs
1 Efficacy Study of Olmesartan Medoxomil on Coronary Atherosclerosis and Epicardial Adipose Tissue(EAT) Unknown status NCT02360956 Phase 4 Olmesartan medoxomil tablets;Antihypertensive medication (per doctor suggestion)
2 The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients With Coronary Artery Disease Unknown status NCT01508663 Phase 4 ARB, CCB, ACE-inhibitor, statin, Nitrate, Antiplate etc.
3 Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
4 Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease Unknown status NCT02514642 Phase 4 low-dose ticagrelor;Clopidogrel
5 Rosuvastatin Effect on Reducing Coronary Atherosclerosis Plaques Volume Unknown status NCT01382277 Phase 4 Rosuvastatin
6 A Trial to Evaluate Efficacy of Heart-protecting Musk Pill Unknown status NCT01897805 Phase 4 Heart-protecting Musk Pill;Placebo
7 Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo
8 Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function Unknown status NCT01825759 Phase 4 danshen dripping pill
9 The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques Unknown status NCT01773512 Phase 4 Rosuvastatin
10 The Association Between Very Small Embryonic-like Stem Cells and the Prognosis of Coronary Artery Disease Patients Unknown status NCT01633359 Phase 4 Intensive statin;Routine statin
11 Ranolazine for Improving Symptoms of Palpitations Unknown status NCT01495520 Phase 4 Ranolazine;Placebo
12 Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
13 Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2 Unknown status NCT01664858 Phase 4
14 Firebird 2 Versus Excel Sirolimus-eluting Stent in Treating Real-world Patients With Coronary Artery Disease Unknown status NCT01373632 Phase 4
15 Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa) Unknown status NCT02030054 Phase 4 Atorvastatin;Rosuvastatin
16 Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
17 Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients Unknown status NCT02001883 Phase 4 Association low-dose statin and nutraceuticals
18 The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease Unknown status NCT02107144 Phase 4 trimetazidine
19 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
20 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Unknown status NCT02457130 Phase 4 Ticagrelor;Clopidogrel
21 Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial) Unknown status NCT00858676 Phase 4 acarbose
22 Xience/Promus for Long Coronary Lesion Registry Unknown status NCT01147237 Phase 4
23 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
24 A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer SES Safety and Effectiveness in CAD Treatment Unknown status NCT01880879 Phase 4
25 Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity Unknown status NCT01567774 Phase 4 Atorvastatin;Rosuvastatin
26 The Effect of Tongguan Capsule for MicroRNA Profiles in Coronary Heart Disease Patients Unknown status NCT02850627 Phase 4 Tongguan capsule;placebo capsule
27 Pharmacodynamic Effects of Ranolazine Versus Amlodipine on Platelet Reactivity Unknown status NCT01490255 Phase 4 Ranolazine;Amlodipine
28 Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients Unknown status NCT00155350 Phase 4 pioglitazone
29 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
30 Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study Unknown status NCT02642419 Phase 4 Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
31 Safety and Effectiveness of the Coronary Momo Stent Unknown status NCT01535625 Phase 4
32 Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate Injection Unknown status NCT02694848 Phase 4 Salvianolate injection;Aspirin
33 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
34 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
35 Ranolazine, Ethnicity and the Metabolic Syndrome Unknown status NCT01304095 Phase 4 Ranolazine
36 Assessment of Surface Coverage of Two Types of DES in Diabetes Mellitus and Non- Diabetes Mellitus Unknown status NCT01023919 Phase 4
37 Overcoming High On-Treatment Platelet Reactivity (HPR) During Prasugrel Therapy With Ticagrelor Unknown status NCT01869309 Phase 4 Prasugrel;Ticagrelor
38 PharmacOdynamic compaRison of piTavastatin Versus atOrvastatin on Platelet Reactivity Unknown status NCT01648829 Phase 4 Atorvastatin;Pitavastatin
39 Multivessel Stenting Versus Staged Revascularization With Zotarolimus-eluting Stent for STEMI Unknown status NCT01781715 Phase 4
40 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
41 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
42 Cholesterol-lowering Effects of nutraceuticaLs Versus Ezetimibe in Statin-intolerant Patients Unknown status NCT01807078 Phase 4 Ezetimibe
43 Diagnostic Benefits of HyperQTM vs. Conventional ECG Stress Test. Comparison of HyperQ vs. Stress ECG in Women Before Angiography Unknown status NCT00850486 Phase 4
44 Comparison of Biolimus-eluting Biodegradable Polymer, Everolimus-eluting and Sirolimus-eluting Coronary Stents Unknown status NCT01268371 Phase 4
45 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
46 A Registry To Evaluate Safety And Effectiveness Of Everolimus Drug Eluting Stent For Coronary Revascularization Unknown status NCT01157455 Phase 4 Aspirin;Clopidogrel;Heparin or Bivalirudin
47 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
48 Italian Diffuse/Multivessel Disease ABSORB Prospective Registry: IT-Disappears Unknown status NCT02004730 Phase 4
49 The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients Unknown status NCT02011906 Phase 4
50 Diagnostic Performance of Noninvasive Fractional Flow Reserve From Computed Tomography Unknown status NCT01747317 Phase 4

Search NIH Clinical Center for Ischemic Heart Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Heart Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Heart Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived mesenchymal stem cells for treatment of ischemic cardiomyopathy during artery bypass grafting
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
itMSC, bone marrow-derived mesenchymal stem cells for cardiovascular diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM
Embryonic/Adult Cultured Cells Related to Ischemic Heart Disease:
Bone marrow-derived CD34+ stem cells (ACT34) PMIDs: 11283669 12551872 22163120 20448213 9020076 17562958 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cells PMIDs: 21082397 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family) PMIDs: 21052537 19591227
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells PMIDs: 22940024 21392602
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mononuclear cells (family) PMIDs: 21392602 22940024
Porcine bone marrow-derived mesenchymal stem cells PMIDs: 21392602 22940024
Human cardiac stem cells PMIDs: 22088800 22965994
Cardiomyocyte-like cells PMIDs: 18941512
Bone marrow-derived progenitor cells PMIDs: 23362308 22936827 18794392 16990384 16990385 22651868
Bone marrow-derived mononuclear cells PMIDs: 21323410 20631864
Bone marrow-derived mesenchymal stem cells PMIDs: 21323410 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells PMIDs: 20668107 21596713 19761394 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel PMIDs: 18720444

Genetic Tests for Ischemic Heart Disease

Anatomical Context for Ischemic Heart Disease

MalaCards organs/tissues related to Ischemic Heart Disease:

41
Heart, Endothelial, Bone, Testes, Kidney, Bone Marrow, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Ischemic Heart Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Limb Pelvic Girdle Bone Marrow Stromal Cells Potential therapeutic candidate
2 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Ischemic Heart Disease

Articles related to Ischemic Heart Disease:

(show top 50) (show all 1216)
# Title Authors Year
1
Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease. ( 29343820 )
2018
2
Coagulation Factors in Ischemic Heart Disease: Answers From a Mendelian Randomization Study Inspire Further Questions. ( 29874185 )
2018
3
Out-of-Hospital Cardiac Arrest in the Presence of Ischemic Heart Disease: What Is the Long-term Arrhythmic Risk After Revascularization? ( 29958725 )
2018
4
Coagulation Factors and the Risk of Ischemic Heart Disease: A Mendelian Randomization Study. ( 29874180 )
2018
5
Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. ( 29850230 )
2018
6
Disconnect Between Genes Associated With Ischemic Heart Disease and Targets of Ischemic Heart Disease Treatments. ( 29396305 )
2018
7
Spontaneously occurring intramural coronary arteriosclerosis in regularly slaughtered veal calves and beef cattle: aA screening study about prevalence and histopathological features. ( 29371083 )
2018
8
Association between unplanned readmission to a different hospital and all-cause mortality among older patients with ischemic heart disease: A nationwide claim study. ( 29371060 )
2018
9
Cerebral Protection During Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Heart Disease. ( 29960991 )
2018
10
Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: The Headache of Nonevidence-Based Medicine for Ischemic Heart Disease? ( 29413373 )
2018
11
Effect of Baseline Antiarrhythmic Drug on Outcomes With Ablation in Ischemic Ventricular Tachycardia: A VANISH Substudy (Ventricular Tachycardia Ablation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease). ( 29305400 )
2018
12
Loss-Framed Financial Incentives and Personalized Goal-Setting to Increase Physical Activity Among Ischemic Heart Disease Patients Using Wearable Devices: The ACTIVE REWARD Randomized Trial. ( 29899015 )
2018
13
Pronounced Coronary Arteriosclerosis in Cirrhosis: Influence on Cardiac Function and Survival? ( 29516327 )
2018
14
Concurrent renal dysfunction with ischemic heart disease is an important determinant for cardiac and cerebrovascular mortality in patients on chronic digoxin therapy for atrial fibrillation. ( 29971208 )
2018
15
The effect of exercise therapy on depressive and anxious symptoms in patients with ischemic heart disease: A systematic review. ( 29332638 )
2018
16
Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study. ( 29337985 )
2018
17
Loss-Framed Financial Incentives With a Wearable Device for Secondary Prevention of Ischemic Heart Disease: Stepping Up to the Challenge? ( 29899016 )
2018
18
Prevalence of Takayasu arteritis in young women with acute ischemic heart disease. ( 29249430 )
2018
19
Relationships between road-distance to primary care facilities and ischemic heart disease and stroke mortality in Hokkaido, Japan: A Bayesian hierarchical approach to ecological count data. ( 29340259 )
2018
20
The association between the serum level of vitamin D and ischemic heart disease: a study from Jordan. ( 29928126 )
2018
21
Outcomes of Care for Ischemic Heart Disease and Chronic Heart Failure in the Veterans Health Administration. ( 29800040 )
2018
22
Optimal Guideline-Directed Medical Therapy for Patients With Stable Ischemic Heart Disease. ( 29903358 )
2018
23
Long-term projections of temperature-related mortality risks for ischemic stroke, hemorrhagic stroke, and acute ischemic heart disease under changing climate in Beijing, China. ( 29241068 )
2018
24
Corrigendum to "Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery" [Med. Hypotheses 104 (2017) 20-24]. ( 29406994 )
2018
25
Hybrid Imaging in Ischemic Heart Disease. ( 29329818 )
2018
26
Coronary Microcirculation in Ischemic Heart Disease. ( 29938611 )
2018
27
Is defibrillator less useful in patients with non-ischemic heart disease? ( 29798811 )
2018
28
Progression of diabetes, ischemic heart disease, and chronic kidney disease in a three chronic conditions multistate model. ( 29914451 )
2018
29
Sex Differences in Ischemic Heart Disease: Advances, Obstacles, and Next Steps. ( 29449443 )
2018
30
Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ. ( 29730730 )
2018
31
Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease. ( 29403392 )
2018
32
Nocturnal hypoventilation may have a protective effect for Ischemic heart disease in Obesity Hypoventilation Syndrome. ( 29911492 )
2018
33
The Role of 27 Human Gut Microbiota Genera in Ischemic Heart Disease, Type 2 Diabetes Mellitus and Their Risk Factors: A Mendelian Randomization Study. ( 29800124 )
2018
34
Chronic Ischemic Heart Disease, Selection of Treatment Modality ( 29939525 )
2018
35
A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain. ( 29351337 )
2018
36
Myocardial Assessment with Cardiac CT: Ischemic Heart Disease and Beyond. ( 29963220 )
2018
37
Reply: Optimal Guideline-Directed Medical Therapy for Patients With Stable Ischemic Heart Disease. ( 29903359 )
2018
38
Favorable effects of statins in the treatment of heart failure with preserved ejection fraction in patients without ischemic heart disease. ( 29307549 )
2018
39
Epistasis analysis of metabolic genes polymorphisms associated with ischemic heart disease in Yucatan. ( 29395491 )
2018
40
Lifestyle factors and subsequent ischemic heart disease risk after hematopoietic cell transplantation. ( 29315507 )
2018
41
Magnetic Resonance Perfusion Imaging to Guide Management of Patients With Stable Ischemic Heart Disease. ( 29976306 )
2018
42
Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke. ( 29317985 )
2017
43
The Association Between Giant Cell Arteritis and Ischemic Heart Disease: A Population Based Cross-Sectional Study. ( 28786254 )
2017
44
Intake of carp meat from two aquaculture production systems aimed at secondary prevention of ischemic heart disease - a follow-up study. ( 28379038 )
2017
45
Differential proteome profile in ischemic heart disease: Prognostic value in chronic angina versus myocardial infarction. A proof of concept. ( 28501389 )
2017
46
HIV and Ischemic Heart Disease. ( 28057253 )
2017
47
High-Sensitivity C-Reactive Protein Is a Predictor of Coronary Microvascular Dysfunction in Patients with Ischemic Heart Disease. ( 29376057 )
2017
48
Small airway dysfunction in smokers with stable ischemic heart disease. ( 28846677 )
2017
49
Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease. ( 28913846 )
2017
50
Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. ( 28757675 )
2017

Variations for Ischemic Heart Disease

Expression for Ischemic Heart Disease

LifeMap Discovery
Genes differentially expressed in tissues of Ischemic Heart Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 EIF1AY eukaryotic translation initiation factor 1A, Y-linked Heart + 3.61 0.020
2 LEP leptin Heart + 3.55 0.003
3 MFSD4 major facilitator superfamily domain containing 4 Endothelium + 3.54 0.000
4 FOSB FBJ murine osteosarcoma viral oncogene homolog B Heart + 3.13 0.012
5 DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked Heart + 3.12 0.017
6 RBP4 retinol binding protein 4, plasma Heart + 3.11 0.011
Search GEO for disease gene expression data for Ischemic Heart Disease.

Pathways for Ischemic Heart Disease

Pathways related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 APOA1 APOB APOE LPL
2
Show member pathways
12.38 APOA1 APOB APOE LPL
3
Show member pathways
12.37 F2 IL6 NOS3 TNF
4
Show member pathways
12.11 APOA1 APOB APOE LPL
5 11.74 IL6 INS LPL TNF
6
Show member pathways
11.72 APOA1 APOB APOE
7 11.69 IL6 INS NOS3
8 11.67 IL6 NOS3 TNF
9
Show member pathways
11.63 APOA1 APOB APOE LPL
10
Show member pathways
11.61 APOA1 APOB APOE CRP F2 F7
11
Show member pathways
11.49 IL6 INS NOS3 TNF
12 11.31 APOB IL6 TNF
13 11.26 APOE IL6 TNF
14 11.22 APOA1 F2 INS
15 11.09 APOA1 IL6 TNF
16 10.73 F2 F7
17 10.41 CRP IL6 TNF

GO Terms for Ischemic Heart Disease

Cellular components related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ACE APOA1 APOB APOE CRP F2