MCID: ISC001
MIFTS: 27

Ischemic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Ischemic Neuropathy

MalaCards integrated aliases for Ischemic Neuropathy:

Name: Ischemic Neuropathy 12 15
Ischemic Peripheral Neuropathy 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1195
NCIt 49 C27025
UMLS 71 C0238309

Summaries for Ischemic Neuropathy

MalaCards based summary : Ischemic Neuropathy, also known as ischemic peripheral neuropathy, is related to nonarteritic anterior ischemic optic neuropathy and optic nerve disease. An important gene associated with Ischemic Neuropathy is MROH8 (Maestro Heat Like Repeat Family Member 8). The drugs Metronidazole and HIV Protease Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and brain.

Related Diseases for Ischemic Neuropathy

Diseases related to Ischemic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 nonarteritic anterior ischemic optic neuropathy 31.8 VEGFA POU4F1
2 optic nerve disease 29.3 VEGFA POU4F1 DPYSL5
3 neuropathy 10.6
4 neuritis 10.0
5 mononeuropathy 10.0
6 ischemia 10.0
7 vasculitis 10.0
8 chorioretinal scar 9.9 VEGFA MROH8
9 intraocular pressure quantitative trait locus 9.9
10 limb ischemia 9.9
11 optic neuritis 9.9
12 peripheral nervous system disease 9.9
13 diabetic neuropathy 9.9
14 wallerian degeneration 9.9
15 systemic lupus erythematosus 9.8
16 lupus erythematosus 9.8
17 amyloidosis 9.8
18 atrial standstill 1 9.7
19 carpal tunnel syndrome 9.7
20 migraine with or without aura 1 9.7
21 parkinson disease, late-onset 9.7
22 buerger disease 9.7
23 ocular motor apraxia 9.7
24 helicobacter pylori infection 9.7
25 microvascular complications of diabetes 5 9.7
26 peripartum cardiomyopathy 9.7
27 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.7
28 peripheral vascular disease 9.7
29 livedoid vasculitis 9.7
30 arteritic anterior ischemic optic neuropathy 9.7
31 suppression amblyopia 9.7
32 amblyopia 9.7
33 corneal edema 9.7
34 acute closed-angle glaucoma 9.7
35 polyneuropathy 9.7
36 papilledema 9.7
37 mitral valve stenosis 9.7
38 vascular disease 9.7
39 mononeuritis multiplex 9.7
40 impotence 9.7
41 hepatitis c 9.7
42 neuroma 9.7
43 arteriosclerosis 9.7
44 retinal vascular disease 9.7
45 sensory peripheral neuropathy 9.7
46 antiphospholipid syndrome 9.7
47 radiculopathy 9.7
48 congestive heart failure 9.7
49 hemarthrosis 9.7
50 polyarteritis nodosa 9.7

Graphical network of the top 20 diseases related to Ischemic Neuropathy:



Diseases related to Ischemic Neuropathy

Symptoms & Phenotypes for Ischemic Neuropathy

Drugs & Therapeutics for Ischemic Neuropathy

Drugs for Ischemic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2 HIV Protease Inhibitors
3
protease inhibitors
4 Serine Proteinase Inhibitors
5 Hemostatics
6 Trypsin Inhibitors
7 Coagulants
8 Nutrients
9 Iron-Dextran Complex
10
Serine Investigational, Nutraceutical 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Preliminary Double Blind Clinical Study, Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
2 Effect of Intraoperative Aprotinin Administration on Post Cardiac Surgery Optic Nerve and Retinal Thickness. Unknown status NCT00395369 intraoperative aprotinin administration
3 Study of Ocular Blood Flow Using Laser Doppler Flowmetry in Patients With Glaucoma and/or OSAS Unknown status NCT00874913
4 Intraneural Facilitation as a Treatment for Carpal Tunnel Syndrome Completed NCT03205683
5 Study of Peripapillary Vasculature With OCT-angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy After Oedema Disappearance Completed NCT03642899
6 Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis Recruiting NCT04042363
7 Assessment of Visual Function With a Portable Brain-computer Interface Enrolling by invitation NCT03760055

Search NIH Clinical Center for Ischemic Neuropathy

Genetic Tests for Ischemic Neuropathy

Anatomical Context for Ischemic Neuropathy

MalaCards organs/tissues related to Ischemic Neuropathy:

40
Bone, Heart, Brain, Eye, Skeletal Muscle, Bone Marrow, Endothelial

Publications for Ischemic Neuropathy

Articles related to Ischemic Neuropathy:

(show top 50) (show all 181)
# Title Authors PMID Year
1
[Amiodarone-induced optic neuropathy: A rare side effect]. 61
31561935 2019
2
Aortic Dissection: An Easily Missed Diagnosis when Pain Doesn't Hold the Stage. 61
31786581 2019
3
Severe Functional Loss of the Hand due to Necrotizing Fasciitis with Underlying Vasculitis Neuropathy. 61
31616126 2019
4
Monomelic Ischemic Neuropathy of the Tibial and Peroneal Nerve After Onyx Embolization of Vasa Nervorum Supplying a Surgically Excluded Popliteal Artery Aneurysm. 61
30963192 2019
5
Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type? 61
30258474 2018
6
Risk of Mortality After Resolution of Spinal Malperfusion in Acute Dissection. 61
29559376 2018
7
Abducens nerve palsy after orbital decompression. 61
29058517 2018
8
[Lo-back pain and compression-ischemic neuropathies: strategies for diagnosis, therapy and rehabilitation]. 61
30499508 2018
9
Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function. 61
28676014 2018
10
Involvement of the Peripheral Nervous System in Polyarteritis Nodosa and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. 61
29061248 2017
11
Diagnosis and management of idiopathic facial palsy in children. 61
29327764 2017
12
Volkmann's ischemic contracture: An unusual complication of arterio-venous fistula. 61
27329788 2017
13
Facial palsy after embolization of dural arteriovenous fistula: A case report and literature review. 61
29204306 2017
14
[A Case of Retroperitoneal Liposarcoma]. 61
28133348 2016
15
Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals. 61
27625964 2016
16
Characterization of nerve and microvessel damage and recovery in type 1 diabetic mice after permanent femoral artery ligation. 61
25944265 2015
17
Magnetic Resonance Findings in Chiasmal and Pregeniculate Ischemic Neuropathy. 61
24705992 2015
18
[Painful ischemic neuropathy]. 61
25620734 2015
19
External iliac artery thrombus masquerading as sciatic nerve palsy in anterior column fracture of the acetabulum. 61
25593363 2015
20
[Mononeuritis multiplex due to thrombotic ischemia of primary antiphospholipid antibody syndrome without vasculitis: an autopsy case report]. 61
26511022 2015
21
Bilateral and simultaneous central retinal vein occlusion in a patient with obstructive sleep apnea syndrome. 61
24987364 2014
22
Two cases of bilateral amiodarone-associated optic neuropathy. 61
24576569 2014
23
Comparison of optic nerve morphology in eyes with glaucoma and eyes with non-arteritic anterior ischemic optic neuropathy by Fourier domain optical coherence tomography. 61
23935759 2013
24
Eleven years of experience with the neurologic complications in Korean patients with acute aortic dissection: a retrospective study. 61
23692963 2013
25
Robust Non-Local Multi-Atlas Segmentation of the Optic Nerve. 61
24478826 2013
26
Most important chronic complications of arteriovenous fistulas for hemodialysis. 61
23128647 2013
27
[Anterior ischemic neuropathy and temporal arteriitis]. 61
23172619 2012
28
Patterns of nerve injury and neuropathic pain in ischemic neuropathy after ligation-reperfusion of femoral artery in mice. 61
22971092 2012
29
Proliferating immature Schwann cells contribute to nerve regeneration after ischemic peripheral nerve injury. 61
22588387 2012
30
[Optic neuritis and optic ischemic neuropathy: the problem of differential diagnosis]. 61
23120916 2012
31
Bilateral Ischemic Optic Neuropathy Developed under Interferon Therapy. 61
23119208 2012
32
Nonarteritic anterior ischemic optic neuropathy and double thrombophilic defect: a new observation. 61
22529804 2012
33
[State of lower alveolar and mental nerves by mandible fractures healing under transbone osteosynthesis]. 61
22968602 2012
34
Ischemic neuropathy associated with livedoid vasculitis. 61
22259622 2011
35
Anterior ischemic optic neuropathy after conventional coronary artery bypass graft surgery. 61
21629193 2011
36
[The influence of photochromotherapy on the injured nerve under experimental conditions (a histological study)]. 61
21837832 2011
37
Posterior optic nerve ischemic neuropathy in the setting of phenoxybenzamine therapy after uneventful spinal fusion. 61
21270647 2011
38
MRI of the eye muscles in a case of ophthalmoplegia caused by common carotid artery occlusion suggests ischemic myopathy. 61
20934191 2011
39
Bilateral nonarteritic anterior ischemic neuropathy following acute angle-closure glaucoma in a patient with iridoschisis: case report. 61
21670912 2011
40
Transient oculomotor palsy after influenza vaccination: short report. 61
22389831 2011
41
Tibial ischemic neuropathy as an unusual complication of interventional radiology. 61
20599385 2010
42
Autologous transplantation of bone marrow mononuclear cells improved ischemic peripheral neuropathy in humans. 61
20620746 2010
43
A case of craniofacial polyostotic fibrous dysplasia. 61
22470752 2010
44
[Migraineous anterior optic ischemic neuropathy]. 61
19809927 2009
45
[Optic neuropathy in Behçet's disease: a series of 18 patients]. 61
19375828 2009
46
Ischemic neuropathy and rhabdomyolysis as presenting symptoms of postpartum cardiomyopathy. 61
18581059 2009
47
Ischemic optic neuropathies. 61
19008740 2008
48
Complications of arteriovenous hemodialysis access: recognition and management. 61
19000594 2008
49
[The electroneuromyographic study of the radial nerve: compressive ischemic neuropathy of the posterior interosseous nerve]. 61
18833118 2008
50
Acute abdominal aortic dissection: insight from the International Registry of Acute Aortic Dissection (IRAD). 61
17980278 2007

Variations for Ischemic Neuropathy

Expression for Ischemic Neuropathy

Search GEO for disease gene expression data for Ischemic Neuropathy.

Pathways for Ischemic Neuropathy

GO Terms for Ischemic Neuropathy

Biological processes related to Ischemic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.13 VEGFA POU4F1 MIR451A
2 mesoderm development GO:0007498 8.62 VEGFA POU4F1

Sources for Ischemic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....