MCID: ISC001
MIFTS: 30

Ischemic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Ischemic Neuropathy

MalaCards integrated aliases for Ischemic Neuropathy:

Name: Ischemic Neuropathy 12 15
Ischemic Peripheral Neuropathy 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1195
NCIt 51 C27025
UMLS 74 C0238309

Summaries for Ischemic Neuropathy

MalaCards based summary : Ischemic Neuropathy, also known as ischemic peripheral neuropathy, is related to nonarteritic anterior ischemic optic neuropathy and livedoid vasculitis. An important gene associated with Ischemic Neuropathy is PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1), and among its related pathways/superpathways is Selenium Micronutrient Network. The drug Metronidazole has been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow.

Related Diseases for Ischemic Neuropathy

Diseases related to Ischemic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 nonarteritic anterior ischemic optic neuropathy 31.7 F2 MTHFR
2 livedoid vasculitis 29.8 F2 MTHFR
3 neuropathy 10.5
4 vitamin metabolic disorder 10.3 ATP4A MTHFR
5 diclofenac allergy 10.3 ATP12A ATP4A
6 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
7 neonatal candidiasis 10.3 ATP12A ATP4A
8 photoallergic dermatitis 10.3 ATP12A ATP4A
9 squamous papillomatosis 10.3 ATP12A ATP4A
10 toxic megacolon 10.2 ATP12A ATP4A
11 aspiration pneumonitis 10.2 ATP12A ATP4A
12 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A
13 gastric antral vascular ectasia 10.2 ATP12A ATP4A
14 granulomatous gastritis 10.2 ATP12A ATP4A
15 mastoiditis 10.2 CRP MTHFR
16 esophageal candidiasis 10.2 ATP12A ATP4A
17 gastric neuroendocrine neoplasm 10.2 ATP12A ATP4A
18 acute laryngitis 10.2 ATP12A ATP4A
19 laryngitis 10.2 ATP12A ATP4A
20 duodenitis 10.2 ATP12A ATP4A
21 rumination disorder 10.2 ATP12A ATP4A
22 congenital disorder of deglycosylation 10.2 ATP12A ATP4A
23 bladder calculus 10.2 ATP12A ATP4A
24 bile reflux 10.2 ATP12A ATP4A
25 capillary disease 10.2 ATP12A ATP4A
26 peptic esophagitis 10.2 ATP12A ATP4A
27 dyskinesia of esophagus 10.2 ATP12A ATP4A
28 hernia, hiatus 10.2 ATP12A ATP4A
29 anismus 10.2 ATP12A ATP4A
30 postsurgical hypothyroidism 10.2 ATP12A ATP4A
31 testicular infarct 10.2 CRP MTHFR
32 lymphocytic colitis 10.2 ATP12A ATP4A
33 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
34 clostridium difficile colitis 10.2 ATP12A ATP4A
35 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
36 esophagitis, eosinophilic, 1 10.2 ATP12A ATP4A
37 microscopic colitis 10.2 ATP12A ATP4A
38 laryngeal tuberculosis 10.2 ATP12A ATP4A
39 chronic laryngitis 10.2 ATP12A ATP4A
40 eosinophilic gastritis 10.2 ATP12A ATP4A
41 esophagus adenocarcinoma 10.2 ATP12A ATP4A
42 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
43 pancreatic steatorrhea 10.2 ATP12A ATP4A
44 gastric lymphoma 10.2 ATP12A ATP4A
45 somatoform disorder 10.2 CABIN1 NGF
46 lower urinary tract calculus 10.2 ATP12A ATP4A
47 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A
48 aspiration pneumonia 10.2 ATP12A ATP4A
49 blind loop syndrome 10.2 ATP12A ATP4A
50 ischemic heart disease 10.2 CRP MTHFR

Graphical network of the top 20 diseases related to Ischemic Neuropathy:



Diseases related to Ischemic Neuropathy

Symptoms & Phenotypes for Ischemic Neuropathy

Drugs & Therapeutics for Ischemic Neuropathy

Drugs for Ischemic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
2 Microwave Radiometry Thermometry for the Diagnosis of Critical Limb Ischemia in Diabetic Patients Completed NCT03002116 Not Applicable
3 OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy Recruiting NCT03642899
4 Assessment of Visual Function With a Portable Brain-computer Interface Enrolling by invitation NCT03760055

Search NIH Clinical Center for Ischemic Neuropathy

Genetic Tests for Ischemic Neuropathy

Anatomical Context for Ischemic Neuropathy

MalaCards organs/tissues related to Ischemic Neuropathy:

42
Brain, Bone, Bone Marrow, Neutrophil

Publications for Ischemic Neuropathy

Articles related to Ischemic Neuropathy:

(show all 37)
# Title Authors Year
1
Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type? ( 30258474 )
2018
2
Magnetic Resonance Findings in Chiasmal and Pregeniculate Ischemic Neuropathy. ( 24705992 )
2014
3
Patterns of nerve injury and neuropathic pain in ischemic neuropathy after ligation-reperfusion of femoral artery in mice. ( 22971092 )
2012
4
Bilateral nonarteritic anterior ischemic neuropathy following acute angle-closure glaucoma in a patient with iridoschisis: case report. ( 21670912 )
2011
5
Posterior optic nerve ischemic neuropathy in the setting of phenoxybenzamine therapy after uneventful spinal fusion. ( 21270647 )
2011
6
Ischemic neuropathy associated with livedoid vasculitis. ( 22259622 )
2011
7
Tibial ischemic neuropathy as an unusual complication of interventional radiology. ( 20599385 )
2010
8
Autologous transplantation of bone marrow mononuclear cells improved ischemic peripheral neuropathy in humans. ( 20620746 )
2010
9
Ischemic neuropathy and rhabdomyolysis as presenting symptoms of postpartum cardiomyopathy. ( 18581059 )
2009
10
Multiple effects of hypothermia on inflammatory response following ischemia-reperfusion injury in experimental ischemic neuropathy. ( 16934252 )
2006
11
The therapeutic window of hypothermic neuroprotection in experimental ischemic neuropathy: protection in ischemic phase and potential deterioration in later reperfusion phase. ( 15950971 )
2005
12
Aortic occlusion causing ischemic neuropathy and paraparesis. ( 15557539 )
2004
13
Bilateral optic ischemic neuropathy related to chronic hepatitis C-associated anticardiolipin antibodies. ( 12736543 )
2003
14
Antiphospholipid antibodies and ischemic neuropathy following cardiac surgery. ( 14626699 )
2003
15
Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia. ( 11346371 )
2001
16
How to avoid and manage nerve injuries associated with aortic surgery: ischemic neuropathy, traction injuries, and sexual derangements. ( 11740835 )
2001
17
Ischemic peripheral neuropathy. ( 11345013 )
2001
18
Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. ( 10742147 )
2000
19
Carotid endarterectomy in a patient with anterior ischemic neuropathy. ( 9845663 )
1998
20
Gastric Helicobacter pylori infection as a cause of idiopathic Parkinson disease and non-arteric anterior optic ischemic neuropathy. ( 8951807 )
1996
21
Systemic lupus erythematosus with ischemic peripheral neuropathy and lupus anticoagulant: response to intravenous prostaglandin E1. ( 8970775 )
1996
22
Experimental ischemic neuropathy: salvage with hyperbaric oxygenation. ( 7818263 )
1995
23
Erythromycin-associated ergotamine intoxication: arteriographic and electrophysiologic analysis of a rare cause of severe ischemia of the lower extremities and associated ischemic neuropathy. ( 8391300 )
1993
24
An animal model of chronic ischemic neuropathy with proliferative changes of nerve microvessel wall. ( 8289080 )
1993
25
Photochemically induced experimental ischemic neuropathy: a clinical, electrophysiological and immunohistochemical study. ( 8410069 )
1993
26
Reversible conduction block in human ischemic neuropathy after ergotamine abuse. ( 1314328 )
1992
27
Optic neuritis and ischemic neuropathy. What we thought we already knew. ( 1841571 )
1991
28
Ischemic neuropathy presenting as prolonged epidural anesthesia. ( 2176816 )
1990
29
Distribution of nerve lesions in serotonin-induced acute ischemic neuropathy. ( 2085092 )
1990
30
Nerve blood flow and oxygen delivery in normal, diabetic, and ischemic neuropathy. ( 2557297 )
1989
31
Lower extremity vasospasm associated with ischemic neuropathy, dermal fibrosis, and digital gangrene in a patient with carcinoid syndrome. ( 3409164 )
1988
32
Ischemic neuropathy. ( 2823402 )
1987
33
Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. ( 7055464 )
1982
34
Selective fiber vulnerability in acute ischemic neuropathy. ( 6280583 )
1982
35
Bilateral acute anterior ischemic neuropathy in diabetes: case report. ( 727626 )
1978
36
Distance Bicycling May Cause Ischemic Neuropathy of Penis. ( 29260943 )
1975
37
Ischemic neuropathy in necrotizing arteries. ( 14402848 )
1960

Variations for Ischemic Neuropathy

Expression for Ischemic Neuropathy

Search GEO for disease gene expression data for Ischemic Neuropathy.

Pathways for Ischemic Neuropathy

Pathways related to Ischemic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 CRP F2 MTHFR

GO Terms for Ischemic Neuropathy

Biological processes related to Ischemic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.43 ATP12A ATP4A
2 acute-phase response GO:0006953 9.4 CRP F2
3 ATP hydrolysis coupled proton transport GO:0015991 9.37 ATP12A ATP4A
4 positive regulation of collagen biosynthetic process GO:0032967 9.32 F2 RGCC
5 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
7 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
8 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Ischemic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Ischemic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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