MCID: ISC001
MIFTS: 27

Ischemic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Ischemic Neuropathy

MalaCards integrated aliases for Ischemic Neuropathy:

Name: Ischemic Neuropathy 12 15
Ischemic Peripheral Neuropathy 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1195
NCIt 50 C27025
SNOMED-CT 68 129611009 230599000
UMLS 73 C0238309

Summaries for Ischemic Neuropathy

MalaCards based summary : Ischemic Neuropathy, also known as ischemic peripheral neuropathy, is related to livedoid vasculopathy and somatoform disorder. An important gene associated with Ischemic Neuropathy is PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1), and among its related pathways/superpathways is Folate Metabolism.

Related Diseases for Ischemic Neuropathy

Diseases related to Ischemic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 livedoid vasculopathy 29.5 F2 MTHFR
2 somatoform disorder 10.5 CABIN1 NGF
3 mastoiditis 10.4 CRP MTHFR
4 testicular infarct 10.4 CRP MTHFR
5 lemierre's syndrome 10.4 CRP MTHFR
6 riboflavin deficiency 10.4 CRP MTHFR
7 neuropathy 10.3
8 bladder calculus 10.3 ATP12A ATP4A
9 gastrointestinal neuroendocrine benign tumor 10.3 ATP12A ATP4A
10 neonatal candidiasis 10.3 ATP12A ATP4A
11 photoallergic dermatitis 10.3 ATP12A ATP4A
12 squamous papillomatosis 10.3 ATP12A ATP4A
13 acute laryngitis 10.3 ATP12A ATP4A
14 bladder disease 10.3 CRP NGF
15 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
16 gastric neuroendocrine neoplasm 10.3 ATP12A ATP4A
17 toxic megacolon 10.3 ATP12A ATP4A
18 aspiration pneumonitis 10.3 ATP12A ATP4A
19 postsurgical hypothyroidism 10.3 ATP12A ATP4A
20 gastric antral vascular ectasia 10.3 ATP12A ATP4A
21 uterine anomalies 10.3 CRP MTHFR
22 esophageal candidiasis 10.3 ATP12A ATP4A
23 duodenitis 10.3 ATP12A ATP4A
24 rumination disorder 10.3 ATP12A ATP4A
25 bile reflux 10.3 ATP12A ATP4A
26 granulomatous gastritis 10.3 ATP12A ATP4A
27 laryngeal disease 10.3 ATP12A ATP4A
28 capillary disease 10.3 ATP12A ATP4A
29 peptic esophagitis 10.3 ATP12A ATP4A
30 duodenal disease 10.3 ATP12A ATP4A
31 dyskinesia of esophagus 10.3 ATP12A ATP4A
32 hernia, hiatus 10.3 ATP12A ATP4A
33 congenital disorder of deglycosylation 10.2 ATP12A ATP4A
34 anismus 10.2 ATP12A ATP4A
35 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
36 laryngitis 10.2 ATP12A ATP4A
37 laryngeal tuberculosis 10.2 ATP12A ATP4A
38 lymphocytic colitis 10.2 ATP12A ATP4A
39 clostridium difficile colitis 10.2 ATP12A ATP4A
40 aspiration pneumonia 10.2 ATP12A ATP4A
41 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
42 chronic laryngitis 10.2 ATP12A ATP4A
43 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
44 eosinophilic gastritis 10.2 ATP12A ATP4A
45 esophagus adenocarcinoma 10.2 ATP12A ATP4A
46 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A
47 gastric lymphoma 10.2 ATP12A ATP4A
48 pancreatic steatorrhea 10.2 ATP12A ATP4A
49 functional gastric disease 10.2 ATP12A ATP4A
50 lateral medullary syndrome 10.2 ATP12A ATP4A

Graphical network of the top 20 diseases related to Ischemic Neuropathy:



Diseases related to Ischemic Neuropathy

Symptoms & Phenotypes for Ischemic Neuropathy

Drugs & Therapeutics for Ischemic Neuropathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
2 Microwave Radiometry Thermometry for the Diagnosis of Critical Limb Ischemia in Diabetic Patients Completed NCT03002116 Not Applicable

Search NIH Clinical Center for Ischemic Neuropathy

Genetic Tests for Ischemic Neuropathy

Anatomical Context for Ischemic Neuropathy

Publications for Ischemic Neuropathy

Articles related to Ischemic Neuropathy:

(show all 31)
# Title Authors Year
1
Magnetic Resonance Findings in Chiasmal and Pregeniculate Ischemic Neuropathy. ( 24705992 )
2014
2
Patterns of nerve injury and neuropathic pain in ischemic neuropathy after ligation-reperfusion of femoral artery in mice. ( 22971092 )
2012
3
Bilateral nonarteritic anterior ischemic neuropathy following acute angle-closure glaucoma in a patient with iridoschisis: case report. ( 21670912 )
2011
4
Posterior optic nerve ischemic neuropathy in the setting of phenoxybenzamine therapy after uneventful spinal fusion. ( 21270647 )
2011
5
Ischemic neuropathy associated with livedoid vasculitis. ( 22259622 )
2011
6
Tibial ischemic neuropathy as an unusual complication of interventional radiology. ( 20599385 )
2010
7
Ischemic neuropathy and rhabdomyolysis as presenting symptoms of postpartum cardiomyopathy. ( 18581059 )
2009
8
Multiple effects of hypothermia on inflammatory response following ischemia-reperfusion injury in experimental ischemic neuropathy. ( 16934252 )
2006
9
The therapeutic window of hypothermic neuroprotection in experimental ischemic neuropathy: protection in ischemic phase and potential deterioration in later reperfusion phase. ( 15950971 )
2005
10
Aortic occlusion causing ischemic neuropathy and paraparesis. ( 15557539 )
2004
11
Bilateral optic ischemic neuropathy related to chronic hepatitis C-associated anticardiolipin antibodies. ( 12736543 )
2003
12
Antiphospholipid antibodies and ischemic neuropathy following cardiac surgery. ( 14626699 )
2003
13
Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia. ( 11346371 )
2001
14
How to avoid and manage nerve injuries associated with aortic surgery: ischemic neuropathy, traction injuries, and sexual derangements. ( 11740835 )
2001
15
Carotid endarterectomy in a patient with anterior ischemic neuropathy. ( 9845663 )
1998
16
Gastric Helicobacter pylori infection as a cause of idiopathic Parkinson disease and non-arteric anterior optic ischemic neuropathy. ( 8951807 )
1996
17
Experimental ischemic neuropathy: salvage with hyperbaric oxygenation. ( 7818263 )
1995
18
Erythromycin-associated ergotamine intoxication: arteriographic and electrophysiologic analysis of a rare cause of severe ischemia of the lower extremities and associated ischemic neuropathy. ( 8391300 )
1993
19
An animal model of chronic ischemic neuropathy with proliferative changes of nerve microvessel wall. ( 8289080 )
1993
20
Photochemically induced experimental ischemic neuropathy: a clinical, electrophysiological and immunohistochemical study. ( 8410069 )
1993
21
Reversible conduction block in human ischemic neuropathy after ergotamine abuse. ( 1314328 )
1992
22
Optic neuritis and ischemic neuropathy. What we thought we already knew. ( 1841571 )
1991
23
Ischemic neuropathy presenting as prolonged epidural anesthesia. ( 2176816 )
1990
24
Distribution of nerve lesions in serotonin-induced acute ischemic neuropathy. ( 2085092 )
1990
25
Nerve blood flow and oxygen delivery in normal, diabetic, and ischemic neuropathy. ( 2557297 )
1989
26
Lower extremity vasospasm associated with ischemic neuropathy, dermal fibrosis, and digital gangrene in a patient with carcinoid syndrome. ( 3409164 )
1988
27
Ischemic neuropathy. ( 2823402 )
1987
28
Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. ( 7055464 )
1982
29
Selective fiber vulnerability in acute ischemic neuropathy. ( 6280583 )
1982
30
Bilateral acute anterior ischemic neuropathy in diabetes: case report. ( 727626 )
1978
31
Ischemic neuropathy in necrotizing arteries. ( 14402848 )
1960

Variations for Ischemic Neuropathy

Expression for Ischemic Neuropathy

Search GEO for disease gene expression data for Ischemic Neuropathy.

Pathways for Ischemic Neuropathy

Pathways related to Ischemic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 CRP F2 MTHFR

GO Terms for Ischemic Neuropathy

Biological processes related to Ischemic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.4 ATP12A ATP4A
2 acute-phase response GO:0006953 9.37 CRP F2
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Ischemic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Ischemic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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