MCID: ISC002
MIFTS: 47

Ischemic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Ischemic Optic Neuropathy

MalaCards integrated aliases for Ischemic Optic Neuropathy:

Name: Ischemic Optic Neuropathy 38
Optic Neuropathy, Ischemic 73

Classifications:



Summaries for Ischemic Optic Neuropathy

MalaCards based summary : Ischemic Optic Neuropathy, also known as optic neuropathy, ischemic, is related to optic nerve disease and amaurosis fugax. An important gene associated with Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Subunit Alpha), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. The drugs 4-Aminopyridine and Carbidopa have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Ischemic Optic Neuropathy

Diseases related to Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 31.8 EDN1 MT-ND1 PDE5A
2 amaurosis fugax 31.0 F5 MTHFR
3 impotence 30.6 EDN1 NOS3 PDE5A
4 nonarteritic anterior ischemic optic neuropathy 30.6 ACE AGTR1 EDN1 F2 F5 GP1BA
5 sleep apnea 30.5 ACE EDN1 NOS3
6 migraine with aura 30.3 ACE F2 MTHFR NOS3
7 arteritic anterior ischemic optic neuropathy 30.1 3.8-1.2 ACE F2 F5 GP1BA GSTM1
8 atrial fibrillation 29.3 ACE AGT AGTR1 F2
9 retinal artery occlusion 29.3 APOH F2 F5 MTHFR SERPINC1
10 retinal vein occlusion 29.2 APOH F2 F5 MTHFR SERPINC1
11 branch retinal artery occlusion 29.1 APOH F2 MTHFR SERPINC1
12 central retinal vein occlusion 29.1 APOH F2 F5 MTHFR SERPINC1
13 thrombophilia 28.9 APOH F2 F5 MTHFR SERPINC1
14 antiphospholipid syndrome 28.9 APOH F2 F5 MTHFR SERPINC1
15 malignant hypertension 28.8 ACE AGT AGTR1 EDN1
16 retinal vascular occlusion 28.8 APOH F2 F5 MTHFR SERPINC1
17 spinal cord infarction 28.6 APOH F2 F5 MTHFR SERPINC1
18 thrombosis 28.6 APOH F2 F5 GP1BA MTHFR SERPINC1
19 pulmonary hypertension 28.1 ACE EDN1 NOS3 PDE5A SERPINC1
20 diabetes mellitus 28.0 ACE AGT AGTR1 EDN1 MT-ND1 NOS3
21 hellp syndrome 27.4 APOH EDN1 F2 F5 MTHFR SERPINC1
22 vascular disease 26.2 ACE APOH EDN1 F2 F5 ITGB3
23 neuropathy 11.2
24 inferior vena cava interruption 11.0 F5 MTHFR
25 paracetamol poisoning 10.9 F2 F5
26 hepatoportal sclerosis 10.9 ACE F2
27 fetal and neonatal alloimmune thrombocytopenia 10.9 GP1BA ITGB3
28 hemifacial spasm 10.9 MTHFR NOS3
29 mesenteric vascular occlusion 10.8 F2 MTHFR
30 cryptogenic cirrhosis 10.8 F2 F5 MTHFR
31 porencephaly 10.8 F2 F5 MTHFR
32 vasculogenic impotence 10.7 ACE NOS3 PDE5A
33 priapism 10.7 F5 NOS3 PDE5A
34 hemoglobin e disease 10.7 F2 F5
35 may-thurner syndrome 10.7 APOH F5
36 hearing loss, noise-induced 10.7 GSTM1 GSTT1
37 von willebrand's disease 10.7 F2 F5 GP1BA
38 ischemic heart disease 10.7 ACE F2 NOS3
39 cerebral atherosclerosis 10.7 ACE MTHFR
40 acanthamoeba keratitis 10.7 APOH F5
41 ischemic neuropathy 10.7 F2 MTHFR
42 sister chromatid exchange, frequency of 10.7 GSTM1 GSTT1
43 cerebral palsy 10.6 F2 F5 MTHFR
44 glanzmann thrombasthenia 10.6 F2 GP1BA ITGB3
45 pediatric hypertension 10.6 ACE AGT
46 coenurosis 10.6 F2 MT-ND1
47 retinitis 10.6
48 bernard-soulier syndrome 10.6 F2 GP1BA ITGB3
49 pregnancy loss, recurrent 1 10.6 APOH F5
50 isolated cleft lip 10.5 GSTM1 GSTT1

Graphical network of the top 20 diseases related to Ischemic Optic Neuropathy:



Diseases related to Ischemic Optic Neuropathy

Symptoms & Phenotypes for Ischemic Optic Neuropathy

MGI Mouse Phenotypes related to Ischemic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 NOS3 EDN1 SERPINC1 F2 F5 ACE
2 cardiovascular system MP:0005385 10.06 EDN1 SERPINC1 F2 F5 ACE FLVCR2
3 mortality/aging MP:0010768 9.93 NOS3 EDN1 F2 SERPINC1 F5 ACE
4 nervous system MP:0003631 9.7 NOS3 EDN1 SERPINC1 F2 F5 FLVCR2
5 renal/urinary system MP:0005367 9.17 NOS3 EDN1 SERPINC1 ACE AGT ITGB3

Drugs & Therapeutics for Ischemic Optic Neuropathy

Drugs for Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 4 504-24-5 1727
2
Carbidopa Approved Phase 4 28860-95-9 34359 38101
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Levodopa Approved Phase 4 59-92-7 6047
5
Ephedrine Approved Phase 4 299-42-3 9294
6
Pseudoephedrine Approved Phase 4 90-82-4 7028
7
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
8
Choline Approved, Nutraceutical Phase 4,Not Applicable 62-49-7 305
9 Autonomic Agents Phase 4,Phase 3,Phase 2
10 Gastrointestinal Agents Phase 4,Phase 3
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Cytidine Diphosphate Choline Phase 4,Not Applicable
13 Nootropic Agents Phase 4,Not Applicable
14 Potassium Channel Blockers Phase 4
15 Adjuvants, Immunologic Phase 4
16 Antiparkinson Agents Phase 4
17 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
18 Carbidopa, levodopa drug combination Phase 4
19 Dopamine Agents Phase 4
20 Dopamine agonists Phase 4
21 Neurotransmitter Agents Phase 4,Phase 1
22 Phosphodiesterase 5 Inhibitors Phase 4
23 Phosphodiesterase Inhibitors Phase 4,Phase 2
24 Adrenergic Agents Phase 4,Phase 1
25 Adrenergic Agonists Phase 4
26 Adrenergic alpha-2 Receptor Agonists Phase 4
27 Adrenergic alpha-Agonists Phase 4
28 Antihypertensive Agents Phase 4,Phase 3,Phase 1
29 Brimonidine Tartrate Phase 4 70359-46-5
30 Carboxymethylcellulose Sodium Phase 4
31 Cathartics Phase 4
32 Laxatives Phase 4
33 Nasal Decongestants Phase 4
34 Ophthalmic Solutions Phase 4
35 Pharmaceutical Solutions Phase 4,Not Applicable
36 Respiratory System Agents Phase 4
37 Tetrahydrozoline Phase 4
38 Vasoconstrictor Agents Phase 4
39 Sildenafil Citrate Phase 4 171599-83-0
40 Vardenafil Dihydrochloride Phase 4
41
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
42
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
43
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
44
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
45 Antiemetics Phase 3
46 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 3
48 glucocorticoids Phase 3,Phase 1,Phase 2
49 Hormone Antagonists Phase 3,Phase 1,Phase 2
50 Hormones Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
3 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
4 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
5 Preoperative Brimonidine on IOP of Patients Undergoing RALP Recruiting NCT02818816 Phase 4 brimonidine tartrate 0.2%
6 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
7 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
8 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
9 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
10 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
11 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Recruiting NCT02377271 Phase 3 bosentan;placebo
12 Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study) Recruiting NCT02376881 Phase 3 Erythropoietin
13 Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Not yet recruiting NCT03547206 Phase 3 RPh201
14 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
15 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
16 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
17 Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy Completed NCT00372021 Phase 1, Phase 2
18 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2 Moxaverine;Moxaverin 150mg;NaCl
19 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Not yet recruiting NCT03173638 Phase 2
20 A Phase I Clinical Trial of DARC Unknown status NCT02394613 Phase 1 ANX776
21 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1 ranibizumab
22 NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement Completed NCT01411657 Phase 1 NT-501 CNTF Implant
23 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1 QPI-1007 at various doses
24 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1 Timolol maleate
25 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126
26 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
27 Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy Completed NCT01614158
28 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
29 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491 Not Applicable
30 A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104 PDE5 Inhibitors
31 Electric Stimulation of the Eye to Improve Vision After Trauma Completed NCT02019927 Not Applicable
32 Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery Completed NCT02643615 Not Applicable Propofol;Desflurane
33 Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair Completed NCT00450294
34 Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours Completed NCT00875043
35 Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569 propofol;Sevoflurane
36 Continuous Intraocular Pressure Patterns in Spine Surgery Completed NCT03299400 Not Applicable
37 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102 Not Applicable
38 Validation of the GATE Software Completed NCT01265628
39 A Study to Assess Whether PDE5 Inhibitors Increase the Chance of Triggering the Onset of Acute NAION Completed NCT00759174 No intervention
40 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892 Not Applicable
41 Effect of EECP on Anterior Ischemic Optic Neuropathy Recruiting NCT01768260 Not Applicable Aspirin
42 Biomechanics of Optic Neuropathy Recruiting NCT02982499
43 New Non-invasive Modalities for Assessing Retinal Structure and Function Recruiting NCT03475173 Not Applicable
44 Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541 Not Applicable
45 Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy Active, not recruiting NCT01338389 Not Applicable
46 Stem Cell Ophthalmology Treatment Study Enrolling by invitation NCT01920867 Not Applicable
47 Swept Source Enhanced Depth Imaging Optical Coherence Tomography Not yet recruiting NCT02443129 Not Applicable
48 Intraocular Pressure During Prone Spinal Surgery Terminated NCT00176722

Search NIH Clinical Center for Ischemic Optic Neuropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Optic Neuropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Optic Neuropathy:
Renexus
Embryonic/Adult Cultured Cells Related to Ischemic Optic Neuropathy:
Human retinal stem cells secreting CNTF PMIDs: 16805711 17508034 16505355 23049090 15684670 12581701 15223826 18830926

Genetic Tests for Ischemic Optic Neuropathy

Anatomical Context for Ischemic Optic Neuropathy

MalaCards organs/tissues related to Ischemic Optic Neuropathy:

41
Eye, Endothelial, Neutrophil, Heart, Retina, Liver, Testes

Publications for Ischemic Optic Neuropathy

Articles related to Ischemic Optic Neuropathy:

(show top 50) (show all 733)
# Title Authors Year
1
Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report. ( 29338755 )
2018
2
Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29784095 )
2018
3
Diffusion-Weighted Imaging Changes in a Child With Posterior Ischemic Optic Neuropathy. ( 29859720 )
2018
4
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )
2018
5
Could Buerger's disease cause nonarteritic anterior ischemic optic neuropathy?: a rare case report. ( 29623524 )
2018
6
Ischemic Optic Neuropathy in a Dog with Acute Bilateral Blindness and Primary Systemic Hypertension. ( 29130572 )
2018
7
An Unforeseeable Complication; Posterior Ischemic Optic Neuropathy after Penetrating Injury to the Heart. ( 29719851 )
2018
8
Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study. ( 29490340 )
2018
9
Postoperative Posterior Ischemic Optic Neuropathy After Left Far-Lateral Craniectomy for Resection of Craniocervical Meningioma. ( 29627627 )
2018
10
Track-weighted imaging for neuroretina: Evaluations in healthy volunteers and ischemic optic neuropathy. ( 29292557 )
2018
11
Intravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy. ( 29521709 )
2018
12
Is Nonarteritic Ischemic Optic Neuropathy Due to Choroidal Compression of the Prelaminar Neurovascular Compartment of the Optic Nerve Head? ( 29438261 )
2018
13
Case of Bilateral Sequential Nonarteritic Ischemic Optic Neuropathy After Rechallenge With Sildenafil. ( 29215388 )
2018
14
Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy. ( 29546060 )
2018
15
Neuroprotective and Anti-Inflammatory Effects of <i>Rhus coriaria</i> Extract in a Mouse Model of Ischemic Optic Neuropathy. ( 29690612 )
2018
16
Haemodilution and head-down tilting induce functional injury in the rat optic nerve: A model for peri-operative ischemic optic neuropathy. ( 29771733 )
2018
17
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. ( 29792847 )
2018
18
Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma. ( 29320503 )
2018
19
Posterior Ischemic Optic Neuropathy After Blepharoplasty. ( 29384801 )
2018
20
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. ( 29642215 )
2018
21
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. ( 29884471 )
2018
22
Risk of Ischemic Kidney Injury in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Population-based Study. ( 29330063 )
2018
23
Steroids versus No Steroids in Nonarteritic Anterior Ischemic Optic Neuropathy: A Randomized Controlled Trial. ( 29705054 )
2018
24
Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29451992 )
2018
25
Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy. ( 29749568 )
2018
26
Anterior Ischemic Optic Neuropathy Due to Calciphylaxis. ( 29016409 )
2018
27
Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma. ( 29911429 )
2018
28
Pathology of Ischemic Optic Neuropathy. ( 28029908 )
2017
29
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. ( 28632028 )
2017
30
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
31
Stem Cell Ophthalmology Treatment Study: bone marrow derived stem cells in the treatment of non-arteritic ischemic optic neuropathy (NAION). ( 29270420 )
2017
32
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. ( 28303068 )
2017
33
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
34
Structure-Function Analysis of Nonarteritic Anterior Ischemic Optic Neuropathy and Age-Related Differences in Outcome. ( 28538035 )
2017
35
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
36
Visual worsening despite resolution of subfoveal fluid in nonarteritic ischemic optic neuropathy. ( 29217047 )
2017
37
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. ( 28861697 )
2017
38
Differences in pupillary light reflex between optic neuritis and ischemic optic neuropathy. ( 29049405 )
2017
39
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2017
40
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28759499 )
2017
41
Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28687846 )
2017
42
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
43
Evaluation of optic nerve head blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy using laser speckle flowgraphy. ( 28786024 )
2017
44
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
45
Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. ( 28986994 )
2017
46
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. ( 28994270 )
2017
47
Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 29485789 )
2017
48
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response. ( 28759500 )
2017
49
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. ( 28836961 )
2017
50
BARTONELLA HENSELAE NEURORETINITIS ASSOCIATED WITH CENTRAL RETINAL VEIN OCCLUSION, CHOROIDAL ISCHEMIA, AND ISCHEMIC OPTIC NEUROPATHY. ( 28700390 )
2017

Variations for Ischemic Optic Neuropathy

Expression for Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Ischemic Optic Neuropathy.

Pathways for Ischemic Optic Neuropathy

Pathways related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 APOH F2 F5 GP1BA ITGB3 NOS3
2
Show member pathways
12.56 AGT AGTR1 EDN1 F2 ITGB3 NOS3
3
Show member pathways
11.76 F2 F5 GP1BA SERPINC1
4 11.63 AGTR1 EDN1 NOS3
5
Show member pathways
11.6 F2 GP1BA ITGB3
6 11.36 ACE AGT AGTR1
7
Show member pathways
11.16 ACE AGT AGTR1 NOS3
8 11.16 EDN1 GSTM1 GSTT1 ITGB3 NOS3
9 10.52 NOS3 PDE5A

GO Terms for Ischemic Optic Neuropathy

Cellular components related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.28 ACE AGT APOH F2 G6PD GP1BA

Biological processes related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.94 AGT EDN1 F2 GP1BA
2 platelet activation GO:0030168 9.85 F2 GP1BA ITGB3
3 kidney development GO:0001822 9.83 ACE AGT AGTR1
4 blood coagulation GO:0007596 9.77 F2 F5 GP1BA ITGB3 SERPINC1
5 glutathione metabolic process GO:0006749 9.74 G6PD GSTM1 GSTT1
6 positive regulation of endothelial cell migration GO:0010595 9.73 AGT EDN1 ITGB3
7 blood vessel remodeling GO:0001974 9.69 ACE AGT NOS3
8 nitric oxide mediated signal transduction GO:0007263 9.67 AGT NOS3
9 vasoconstriction GO:0042310 9.67 AGT EDN1
10 positive regulation of reactive oxygen species metabolic process GO:2000379 9.67 AGT AGTR1 F2
11 positive regulation of cellular protein metabolic process GO:0032270 9.66 AGT AGTR1
12 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.65 AGT AGTR1
13 negative regulation of blood coagulation GO:0030195 9.65 APOH EDN1
14 positive regulation of renal sodium excretion GO:0035815 9.65 AGT EDN1
15 regulation of blood vessel diameter GO:0097746 9.64 ACE AGTR1
16 positive regulation of blood coagulation GO:0030194 9.63 APOH F2
17 low-density lipoprotein particle remodeling GO:0034374 9.63 AGT AGTR1
18 positive regulation of cardiac muscle hypertrophy GO:0010613 9.63 AGT EDN1 PDE5A
19 angiotensin maturation GO:0002003 9.62 ACE AGT
20 artery smooth muscle contraction GO:0014824 9.62 AGT EDN1
21 regulation of blood pressure GO:0008217 9.62 ACE AGT EDN1 NOS3
22 negative regulation of fibrinolysis GO:0051918 9.61 APOH F2
23 positive regulation of cholesterol esterification GO:0010873 9.61 AGT AGTR1
24 regulation of blood vessel size GO:0050880 9.61 AGT EDN1 NOS3
25 negative regulation of platelet activation GO:0010544 9.6 F2 NOS3
26 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.59 APOH EDN1
27 positive regulation of NAD(P)H oxidase activity GO:0033864 9.58 AGT AGTR1
28 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.58 EDN1 NOS3
29 blood coagulation, intrinsic pathway GO:0007597 9.58 APOH F2 GP1BA
30 hemostasis GO:0007599 9.56 F2 F5 GP1BA SERPINC1
31 regulation of renal sodium excretion GO:0035813 9.55 AGT AGTR1
32 renin-angiotensin regulation of aldosterone production GO:0002018 9.54 AGT AGTR1
33 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.52 AGT AGTR1
34 regulation of renal output by angiotensin GO:0002019 9.48 ACE AGT
35 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 ACE AGT AGTR1
36 regulation of vasoconstriction GO:0019229 9.26 ACE AGT AGTR1 EDN1
37 regulation of blood coagulation GO:0030193 8.92 APOH F2 GP1BA SERPINC1

Molecular functions related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.13 G6PD MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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