Aliases & Classifications for Ischemic Retinopathy

MalaCards integrated aliases for Ischemic Retinopathy:

Name: Ischemic Retinopathy 55

Summaries for Ischemic Retinopathy

MalaCards based summary : Ischemic Retinopathy is related to retinitis and hypoxia. An important gene associated with Ischemic Retinopathy is PLXND1 (Plexin D1), and among its related pathways/superpathways is Semaphorin interactions. The drugs Abatacept and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial.

Related Diseases for Ischemic Retinopathy

Graphical network of the top 20 diseases related to Ischemic Retinopathy:



Diseases related to Ischemic Retinopathy

Symptoms & Phenotypes for Ischemic Retinopathy

Drugs & Therapeutics for Ischemic Retinopathy

Drugs for Ischemic Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 2 332348-12-6 10237
2
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
3 glucocorticoids Phase 2
4 Immunosuppressive Agents Phase 2
5 Antirheumatic Agents Phase 2
6
Ranibizumab Approved Not Applicable 347396-82-1 459903
7
Ciprofloxacin Approved, Investigational Not Applicable 85721-33-1 2764
8
Iodine Approved, Investigational Not Applicable 7553-56-2 807
9
Povidone-iodine Approved Not Applicable 25655-41-8
10
Povidone Approved Not Applicable 9003-39-8
11 Angiogenesis Inhibitors Not Applicable
12 Angiogenesis Modulating Agents Not Applicable
13 cadexomer iodine Not Applicable
14 Proxymetacaine Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2 Abatacept;Placebo
2 Study to Evaluate the Effects of Ranibizumab (Lucentis) for Patients With Rubeosis and Neovascular Glaucoma Completed NCT01370135 Not Applicable 0.5mg intraocular Ranibizumab (Lucentis)
3 Effect of Intravitreal Bone Marrow Stem Cells on Ischemic Retinopathy Active, not recruiting NCT01518842 Not Applicable

Search NIH Clinical Center for Ischemic Retinopathy

Genetic Tests for Ischemic Retinopathy

Anatomical Context for Ischemic Retinopathy

MalaCards organs/tissues related to Ischemic Retinopathy:

41
Bone, Bone Marrow, Endothelial, Myeloid, Retina

Publications for Ischemic Retinopathy

Articles related to Ischemic Retinopathy:

(show top 50) (show all 80)
# Title Authors Year
1
High protein S activity due to C4b-binding protein deficiency in a 34-year-old Surinamese female with ischemic retinopathy. ( 29744091 )
2018
2
Inhibition or deletion of 11I^-HSD1 does not increase angiogenesis in ischemic retinopathy. ( 28089372 )
2017
3
Impact of minocycline on vascularization and visual function in an immature mouse model of ischemic retinopathy. ( 28790417 )
2017
4
Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. ( 28469167 )
2017
5
An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice. ( 29118394 )
2017
6
MicroRNA-126 Reduces Blood-Retina Barrier Breakdown via the Regulation of VCAM-1 and BCL2L11 in Ischemic Retinopathy. ( 28076855 )
2017
7
Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy. ( 28257831 )
2017
8
Evaluation of Nonperfused Retinal Vessels in Ischemic Retinopathy. ( 27661854 )
2016
9
Global metabolomics reveals metabolic dysregulation in ischemic retinopathy. ( 26617478 )
2016
10
Ischemic retinopathy associated with Crohn's disease. ( 27524921 )
2016
11
Intractable Intradialytic Hypotension with Ischemic Retinopathy. ( 27915344 )
2016
12
Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy. ( 27239699 )
2016
13
Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy. ( 27654416 )
2016
14
Gemigliptin, a dipeptidyl peptidase-4 inhibitor, inhibits retinal pericyte injury in db/db mice and retinal neovascularization in mice with ischemic retinopathy. ( 26391252 )
2015
15
Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy. ( 25985753 )
2015
16
A platform of integrative studies from in vitro to in vivo experiments: towards drug development for ischemic retinopathy. ( 25661384 )
2015
17
Severe ischemic retinopathy in a patient with systemic lupus erythematosus without antiphospholipid syndrome: A case report. ( 25892939 )
2015
18
ISCHEMIC RETINOPATHY IN NEUROFIBROMATOSIS TYPE 1. ( 26252734 )
2015
19
Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1). ( 25420481 )
2015
20
S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression. ( 26358273 )
2015
21
Activation of the Endothelin System Mediates Pathological Angiogenesis during Ischemic Retinopathy. ( 25203536 )
2014
22
Proliferative ischemic retinopathy after arteriovenous malformation embolization in a child with hereditary hemorrhagic telangiectasia. ( 25372443 )
2014
23
Ischemic retinopathy and neovascular proliferation secondary to severe head injury. ( 25143848 )
2014
24
Angiopoietin-1 guides directional angiogenesis through integrin I+vI^5 signaling for recovery of ischemic retinopathy. ( 24048525 )
2013
25
Microglia and interleukin-1I^ in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A. ( 23766263 )
2013
26
Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. ( 23912262 )
2013
27
NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy. ( 24053718 )
2013
28
Vitreous haemorrhage and ischemic retinopathy in a patient with CADASIL. ( 23064698 )
2013
29
Targeting Neovascularization in Ischemic Retinopathy: Recent Advances. ( 25598837 )
2013
30
Peripheral ischemic retinopathy in Adams-Oliver syndrome. ( 22893088 )
2012
31
Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. ( 22342523 )
2012
32
Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy. ( 23209723 )
2012
33
Hypoxia-induced oxidative stress in ischemic retinopathy. ( 23125893 )
2012
34
Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy. ( 23285156 )
2012
35
Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression. ( 23233787 )
2012
36
Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. ( 21505259 )
2011
37
Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration. ( 21873682 )
2011
38
Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion. ( 20804843 )
2011
39
Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. ( 21228311 )
2011
40
Hyperoxia therapy of pre-proliferative ischemic retinopathy in a mouse model. ( 21705685 )
2011
41
Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy. ( 22355595 )
2011
42
The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy. ( 21212276 )
2011
43
Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-/- mice in ischemic retinopathy. ( 20107169 )
2010
44
Reversal of ischemic retinopathy following balloon angioplasty of a stenotic ophthalmic artery. ( 20418775 )
2010
45
Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy. ( 20554606 )
2010
46
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy. ( 19815813 )
2010
47
Moderate GSK-3I^ inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. ( 20809259 )
2010
48
Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy. ( 19536308 )
2009
49
Stimulating angiogenesis to prevent ischemic retinopathy. ( 19729095 )
2009
50
Effects of intravitreal morphine administered at different time points after reperfusion in a rabbit model of ischemic retinopathy. ( 18854781 )
2009

Variations for Ischemic Retinopathy

Expression for Ischemic Retinopathy

Search GEO for disease gene expression data for Ischemic Retinopathy.

Pathways for Ischemic Retinopathy

GO Terms for Ischemic Retinopathy

Biological processes related to Ischemic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.26 PLXND1 SEMA3E
2 regulation of cell shape GO:0008360 9.16 PLXND1 SEMA3E
3 semaphorin-plexin signaling pathway GO:0071526 8.96 PLXND1 SEMA3E
4 branching involved in blood vessel morphogenesis GO:0001569 8.62 PLXND1 SEMA3E

Sources for Ischemic Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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