MCID: ISL109
MIFTS: 20

Isolated Cleft Lip

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Isolated Cleft Lip

MalaCards integrated aliases for Isolated Cleft Lip:

Name: Isolated Cleft Lip 59

Classifications:



External Ids:

Orphanet 59 ORPHA199302
UMLS via Orphanet 74 C0008924
ICD10 via Orphanet 34 Q36.0 Q36.1 Q36.9

Summaries for Isolated Cleft Lip

MalaCards based summary : Isolated Cleft Lip is related to cleft lip and cleft lip/palate. An important gene associated with Isolated Cleft Lip is IRF6 (Interferon Regulatory Factor 6). Affiliated tissues include brain, bone and pituitary.

Related Diseases for Isolated Cleft Lip

Diseases related to Isolated Cleft Lip via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cleft lip 10.7
2 cleft lip/palate 10.5
3 cleft palate, isolated 10.4
4 sleep apnea 9.9
5 hypothyroidism 9.9
6 aggressive periodontitis 9.9
7 thyroid cancer 9.9
8 periodontitis 9.9

Graphical network of the top 20 diseases related to Isolated Cleft Lip:



Diseases related to Isolated Cleft Lip

Symptoms & Phenotypes for Isolated Cleft Lip

Drugs & Therapeutics for Isolated Cleft Lip

Search Clinical Trials , NIH Clinical Center for Isolated Cleft Lip

Genetic Tests for Isolated Cleft Lip

Anatomical Context for Isolated Cleft Lip

MalaCards organs/tissues related to Isolated Cleft Lip:

41
Brain, Bone, Pituitary, Thyroid

Publications for Isolated Cleft Lip

Articles related to Isolated Cleft Lip:

(show all 42)
# Title Authors Year
1
Rethinking isolated cleft lip and palate as a syndrome. ( 29500156 )
2018
2
A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in <i>ESRRG</i>. ( 29535761 )
2018
3
Isolated Cleft Lip and Palate: Maxillary Gap Sign and Palatino-Maxillary Diameter at 11-13 Weeks. ( 29073631 )
2017
4
The detection of areas in Poland with an increased prevalence of isolated cleft lip with or without cleft palate. ( 25780839 )
2015
5
Ear Infection in Isolated Cleft Lip: Etiological Implications. ( 26153759 )
2015
6
Isolated cleft lip with generalized aggressive periodontitis: A rare entity. ( 25810600 )
2015
7
High-Resolution Array Comparative Genomic Hybridization Utility in Polish Newborns with Isolated Cleft Lip and Palate. ( 25613075 )
2015
8
Parental age and the risk of isolated cleft lip: a registry-based study. ( 26092647 )
2015
9
A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1. ( 25652407 )
2015
10
Incidence of positive screening for obstructive sleep apnea in patients with isolated cleft lip and/or palate. ( 25535465 )
2014
11
Spatial and temporal clustering of isolated cleft lip with or without cleft palate in Poland. ( 24559046 )
2014
12
Additional post-natal diagnoses following antenatal diagnosis of isolated cleft lip +/a89 palate. ( 24625434 )
2014
13
A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk. ( 24528994 )
2014
14
Is fetal cerebral MRI worthwhile in antenatally diagnosed isolated cleft lip with or without palate? ( 23355017 )
2013
15
Social motivation in individuals with isolated cleft lip and palate. ( 23634967 )
2013
16
Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate. ( 22322386 )
2012
17
Risk of cancer in relatives of children born with isolated cleft lip and palate. ( 22585460 )
2012
18
Growth trajectory of children and adolescents with isolated cleft lip and/or palate through the first two decades of life. ( 22832665 )
2012
19
Fetal genetic risk of isolated cleft lip only versus isolated cleft lip and palate: a subphenotype analysis using two population-based studies of orofacial clefts in Scandinavia. ( 21319277 )
2011
20
Is an isolated cleft lip an isolated anomaly? ( 21146482 )
2011
21
Maternal uniparental heterodisomy of chromosome 6 in a boy with an isolated cleft lip and palate. ( 20583164 )
2010
22
Fetoscopic imaging of isolated cleft lip. ( 22778376 )
2010
23
Evaluation of growth in patients with isolated cleft lip and/or cleft palate. ( 20142284 )
2010
24
FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. ( 19779022 )
2009
25
Craniofacial cephalometric morphology in 6-year-old children with isolated cleft lip, isolated submucous cleft palate, and combined cleft lip and submucous cleft palate. ( 17605436 )
2007
26
Contributions of PTCH gene variants to isolated cleft lip and palate. ( 16405370 )
2006
27
[Genetic polymorphisms of GSTM1 and GSTT1 in mothers of children with isolated cleft lip with or without cleft palate]. ( 16521944 )
2005
28
Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population. ( 16132054 )
2005
29
The IRF6 p.274V polymorphism is not a risk factor for isolated cleft lip. ( 15775759 )
2005
30
An epidemiologic study of isolated cleft lip, palate, or both in Victoria, Australia from 1983 to 2000. ( 14989685 )
2004
31
Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. ( 15317890 )
2004
32
Finding needles in haystacks--IRF6 gene variants in isolated cleft lip or cleft palate. ( 15317897 )
2004
33
Ultrasonographic detection of orbicularis oris defects in first degree relatives of isolated cleft lip patients. ( 10607956 )
2000
34
Abnormal brain morphology in patients with isolated cleft lip, cleft palate, or both: a preliminary analysis. ( 11034025 )
2000
35
A prospective evaluation of the prevalence of submucous cleft palate in patients with isolated cleft lip versus controls. ( 10359245 )
1999
36
Stature of Russian children with isolated cleft lip and palate. ( 9832221 )
1998
37
Millard repair of unilateral isolated cleft lip: a 25-year follow-up. ( 9862106 )
1998
38
Developmental dental changes in isolated cleft lip and palate. ( 9106872 )
1997
39
Bone grafting the piriform aperture deformity in isolated cleft lip patients: indication, technique, and results. ( 9331231 )
1997
40
Size and form of the cranial base in isolated cleft lip and palate. ( 8452839 )
1993
41
Delayed dental development in children with isolated cleft lip and palate. ( 2372250 )
1990
42
The isolated cleft lip nose. Report of five cases in adults. ( 5639207 )
1968

Variations for Isolated Cleft Lip

Expression for Isolated Cleft Lip

Search GEO for disease gene expression data for Isolated Cleft Lip.

Pathways for Isolated Cleft Lip

GO Terms for Isolated Cleft Lip

Sources for Isolated Cleft Lip

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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