ION
MCID: ISL119
MIFTS: 36

Isolated Optic Neuritis (ION)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Isolated Optic Neuritis

MalaCards integrated aliases for Isolated Optic Neuritis:

Name: Isolated Optic Neuritis 59
Ion 59

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA499096

Summaries for Isolated Optic Neuritis

MalaCards based summary : Isolated Optic Neuritis, also known as ion, is related to multiple sclerosis and hyperphenylalaninemia. An important gene associated with Isolated Optic Neuritis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Neuroscience and MECP2 and Associated Rett Syndrome. Affiliated tissues include lung, brain and liver, and related phenotype is Negative genetic interaction between BLM-/- and BLM+/+.

Related Diseases for Isolated Optic Neuritis

Diseases related to Isolated Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 594)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 29.9 CNP MBP
2 hyperphenylalaninemia 29.3 CNP MBP
3 schizophrenia 29.1 CNP MBP
4 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.5
5 pseudohypoaldosteronism, type iid 11.4
6 chronic relapsing inflammatory optic neuropathy 11.3
7 metabolic acidosis 11.3
8 hyperuricemia 11.2
9 short qt syndrome 11.2
10 osteomalacia 11.2
11 gitelman syndrome 11.2
12 renal tubular acidosis 11.1
13 familial periodic paralysis 11.1
14 hyperaldosteronism, familial, type i 10.9
15 axial osteomalacia 10.9
16 jalili syndrome 10.9
17 fructose-1,6-bisphosphatase deficiency 10.9
18 eosinophil peroxidase deficiency 10.9
19 rh-null, regulator type 10.9
20 hyperaldosteronism, familial, type ii 10.9
21 nephrolithiasis, uric acid 10.9
22 hyperinsulinemic hypoglycemia, familial, 6 10.9
23 qt interval, variation in 10.9
24 secretory diarrhea 10.9
25 juvenile absence epilepsy 10.9
26 bartter syndrome type 4 10.9
27 hyper-reninism 10.9
28 triiodothyronine receptor auxiliary protein 10.6
29 prostate cancer 10.6
30 optic neuritis 10.6
31 neuritis 10.6
32 polycystic kidney disease 10.5
33 rheumatoid arthritis 10.5
34 endometriosis 10.4
35 cystic fibrosis 10.2
36 streptococcal group a invasive disease 10.2
37 tetralogy of fallot 10.2
38 pancreatic ductal adenocarcinoma 10.1
39 chordoma 10.1
40 melanoma 10.1
41 long qt syndrome 10.1
42 adamantinoma of long bones 10.1
43 retinitis pigmentosa 10.1
44 rapidly involuting congenital hemangioma 10.1
45 retinoblastoma 10.1
46 alzheimer disease 10.1
47 lung cancer 10.0
48 neuroblastoma 10.0
49 pancreatic cancer 10.0
50 primary orthostatic tremor 10.0

Graphical network of the top 20 diseases related to Isolated Optic Neuritis:



Diseases related to Isolated Optic Neuritis

Symptoms & Phenotypes for Isolated Optic Neuritis

GenomeRNAi Phenotypes related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.62 CNP MBP

Drugs & Therapeutics for Isolated Optic Neuritis

Search Clinical Trials , NIH Clinical Center for Isolated Optic Neuritis

Genetic Tests for Isolated Optic Neuritis

Anatomical Context for Isolated Optic Neuritis

MalaCards organs/tissues related to Isolated Optic Neuritis:

41
Lung, Brain, Liver, Bone, Testes, Eye, T Cells

Publications for Isolated Optic Neuritis

Articles related to Isolated Optic Neuritis:

(show top 50) (show all 1031)
# Title Authors Year
1
Discrimination of dried sea cucumber (Apostichopus japonicus) products from different geographical origins by sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS)-based proteomic analysis and chemometrics. ( 30372983 )
2019
2
An improved "ion pairing agent free" HPLC-RP method for testing cAMP Phosphodiesterase activity. ( 30348395 )
2019
3
Application of a novel compact Cs evaporator prototype for enhancing negative ion yields during FIB-TOF-SIMS analysis in high vacuum. ( 30267991 )
2019
4
Large-scale profiling of carotenoids by using non aqueous reversed phase liquid chromatography - photodiode array detection - triple quadrupole linear ion trap mass spectrometry: Application to some varieties of sweet pepper (Capsicum annuum L.). ( 30481639 )
2019
5
The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma. ( 30406211 )
2019
6
Mitigation of Volume Expansion of Silica Anodes by Porous Titanium Dioxide Coating for Lithium-Ion Batteries. ( 30469216 )
2019
7
MoS₂-TiC-C Nanocomposites as New Anode Materials for High-Performance Lithium-Ion Batteries. ( 30360188 )
2019
8
Microstructure and Mechanical Properties of Functional Graded Ti-Al-Si-N-O Nanocomposite Films Deposited by Filtered Arc Ion Plating Technique. ( 30360206 )
2019
9
One-Pot Decoration of Graphene with SnO₂ Nanocrystals by an Elevated Hydrothermal Process and Their Application as Anode Materials for Lithium Ion Batteries. ( 30360162 )
2019
10
Ion mobility spectrometry coupled to gas chromatography: A rapid tool to assess eggs freshness. ( 30236732 )
2019
11
Role of Hydrophilic APTES-PP Separator in Enhancing the Electrochemical Performance of Ni-Rich Cathode for Li-Ion Battery. ( 30469183 )
2019
12
Thermally stable and green cellulose-based composites strengthened by styrene-co-acrylate latex for lithium-ion battery separators. ( 30553387 )
2019
13
Investigation of In-Situ Carbon Coated LiFePO₄ as a Superior Cathode Material for Lithium Ion Batteries. ( 30501812 )
2019
14
Effects of calcium ion on gel properties and gelation of tilapia (Oreochromis niloticus) protein isolates processed with pH shift method. ( 30502154 )
2019
15
Fabrication and application of nanoporous polymer ion-track membranes. ( 30511655 )
2019
16
Computational design of metal-supported molecular switches: transient ion formation during light- and electron-induced isomerisation of azobenzene. ( 30523934 )
2019
17
Effect of precipitation pH and coexisting magnesium ion on phosphate adsorption onto hydrous zirconium oxide. ( 30528008 )
2019
18
Basics on the use of acid-sensing ion channels' inhibitors as therapeutics. ( 30539804 )
2019
19
Novel Core-Shell-Type Design of Na0.5[Li0.5(Ni0.8Co0.1Mn0.1)1-x(Ni0.5 Co0.1Mn0.4)x]O₂ Cathode Material for Sodium-Ion Batteries. ( 30469184 )
2019
20
New Observation Structural Change from O3 to P2 Type by Changing Sodium Contents for Na-Ion Batteries. ( 30469189 )
2019
21
Study of Annealing Influence on Basic Properties of Indium Tin Oxide Nanorod Films Deposited Using Glancing Angle Ion-Assisted Electron Beam Evaporation. ( 30469201 )
2019
22
Facile and Scalable Preparation of a MoS₂/Carbon Nanotube Nanocomposite Anode for High-Performance Lithium-Ion Batteries: Effects of Carbon Nanotube Content. ( 30469212 )
2019
23
Use of polymeric sub-micron ion-exchange resins for removal of lead, copper, zinc, and nickel from natural waters. ( 30473290 )
2019
24
Effects of Molybdenum on Improvement of Anti-Corrosion by Plasma Ion Nitriding for Austenitic Stainless Steels. ( 30486967 )
2019
25
Conformal carbon coating on WS2 nanotubes for excellent electrochemical performance of lithium-ion batteries. ( 30444729 )
2019
26
Genotyping-by-Sequencing on the Ion Torrent Platform in Barley. ( 30460569 )
2019
27
Pseudocapacitive Li-ion storage boosts high-capacity and long-life performance in multi-layer CoFe2O4/rGO/C composite. ( 30465545 )
2019
28
Comprehensive metabolic profile of phenolic acids and flavonoids in Glechomae Herba using ultra-high-performance liquid chromatography coupled to quadrupole-time-of-flight tandem mass spectrometry with diagnostic ion filtering strategy. ( 30469111 )
2019
29
Carbon-enhanced centrifugally-spun SnSb/carbon microfiber composite as advanced anode material for sodium-ion battery. ( 30396121 )
2019
30
In situ synthesis of carbon doped porous silicon nanocomposites as high-performance anodes for lithium-ion batteries. ( 30418956 )
2019
31
Particulate and ion forms of cobalt-chromium challenged preosteoblasts promote osteoclastogenesis and osteolysis in a murine model of prosthesis failure. ( 30358096 )
2019
32
Water, sediment and agricultural soil contamination from an ion-adsorption rare earth mining area. ( 30359919 )
2019
33
Molybdenum Oxide and Hybride Films as Anodes for Lithium Ion Batteries. ( 30360177 )
2019
34
Electrochemical Performance of Sn/SnO/Ni3Sn Composite Anodes for Lithium-Ion Batteries. ( 30360189 )
2019
35
Removal of Heavy Metal Ion in Wastewater by Dendritic Nano-Structured Complex Material. ( 30360191 )
2019
36
One-step mild fabrication of porous core-shelled Si@TiO2 nanocomposite as high performance anode for Li-ion batteries. ( 30366182 )
2019
37
Paper-based ion-selective optodes for continuous sensing: Reversible potassium ion monitoring. ( 30368297 )
2019
38
Single injection ion-exclusion/cation-exchange chromatography for simultaneous determination of organic/inorganic anions, inorganic cations, and ethanol in beer samples. ( 30372994 )
2019
39
In situ synthesis of open hollow tubular MnO/C with high performance anode materials for lithium ion batteries using kapok fiber as carbon matrix. ( 30375360 )
2019
40
In-situ ion exchange electrocatalysis biological coupling (i-IEEBC) for simultaneously enhanced degradation of organic pollutants and heavy metals in electroplating wastewater. ( 30388640 )
2019
41
Adsorption characteristics of ammonium ion onto hydrous biochars in dilute aqueous solutions. ( 30390539 )
2019
42
Formation of multilayer through layer-by-layer assembly of starch-based polyanion with divalent metal ion. ( 30318229 )
2019
43
A Review of Electrode for Rechargeable Magnesium Ion Batteries. ( 30326998 )
2019
44
Controllable Synthesis of Hierarchical Rose-Like MnCo₂O₄ Spinel as Lithium-Ion Anode Materials. ( 30327014 )
2019
45
Facile Synthesis of Tremella-Like V₂O5 Microspheres and Their Application as Cathode Materials in Lithium Ion Batteries. ( 30327022 )
2019
46
Electrospun Carbon Nanofiber/Boron Nitride Composites as Flexible Anodes for Lithium-Ion Batteries. ( 30327026 )
2019
47
TiO₂ Nanotubes Array on Carbon Cloth as a Flexibility Anode for Sodium-Ion Batteries. ( 30327027 )
2019
48
Design of Rugby-Like GeO₂ Grown on Carbon Cloth as a Flexible Anode for High-Performance Lithium-Ion Batteries. ( 30327034 )
2019
49
Facile Preparation of Nb₂O5@Carbon Hollow Microspheres as High-Performance Anode Materials for Lithium-Ion Batteries. ( 30327035 )
2019
50
Computational simulations of the mass transfer zone in GS adsorption column packed with Fe3+ type ion exchanger. ( 30340159 )
2019

Variations for Isolated Optic Neuritis

Expression for Isolated Optic Neuritis

Search GEO for disease gene expression data for Isolated Optic Neuritis.

Pathways for Isolated Optic Neuritis

Pathways related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.69 CNP MBP
2 10.75 CNP MBP
3 9.53 CNP MBP

GO Terms for Isolated Optic Neuritis

Cellular components related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 8.96 CNP MBP
2 myelin sheath GO:0043209 8.62 CNP MBP

Biological processes related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.16 CNP MBP
2 response to toxic substance GO:0009636 8.96 CNP MBP
3 substantia nigra development GO:0021762 8.62 CNP MBP

Sources for Isolated Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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