MCID: ISL119
MIFTS: 24

Isolated Optic Neuritis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Isolated Optic Neuritis

MalaCards integrated aliases for Isolated Optic Neuritis:

Name: Isolated Optic Neuritis 59
Ion 59

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA499096

Summaries for Isolated Optic Neuritis

MalaCards based summary : Isolated Optic Neuritis, also known as ion, is related to multiple sclerosis and pseudohypoaldosteronism, type iid. An important gene associated with Isolated Optic Neuritis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Neuroscience and MECP2 and Associated Rett Syndrome. Affiliated tissues include eye, t cells and spinal cord, and related phenotype is Negative genetic interaction between BLM-/- and BLM+/+.

Related Diseases for Isolated Optic Neuritis

Diseases related to Isolated Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 28.8 CNP MBP
2 pseudohypoaldosteronism, type iid 11.2
3 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 11.2
4 chronic relapsing inflammatory optic neuropathy 11.2
5 metabolic acidosis 11.1
6 hyperuricemia 11.1
7 osteomalacia 11.1
8 gitelman syndrome 11.0
9 epilepsy, idiopathic generalized 10 11.0
10 renal tubular acidosis 10.9
11 familial periodic paralysis 10.9
12 jalili syndrome 10.7
13 fructose-1,6-bisphosphatase deficiency 10.7
14 eosinophil peroxidase deficiency 10.7
15 hyperaldosteronism, familial, type i 10.7
16 rh-null, regulator type 10.7
17 secretory diarrhea 10.7
18 axial osteomalacia 10.7
19 hyperaldosteronism, familial, type ii 10.7
20 juvenile absence epilepsy 10.7
21 nephrolithiasis, uric acid 10.7
22 hyperinsulinemic hypoglycemia, familial, 6 10.7
23 qt interval, variation in 10.7
24 bartter syndrome type 4 10.7
25 hyper-reninism 10.7
26 prostate cancer 10.5
27 neuritis 10.4
28 optic neuritis 10.4
29 polycystic kidney disease 10.4
30 neuronitis 10.3
31 pancreatitis 10.1
32 cystic fibrosis 10.1
33 long qt syndrome 10.0
34 retinitis 10.0
35 prostatitis 10.0
36 melanoma 10.0
37 chordoma 10.0
38 pancreatic ductal adenocarcinoma 10.0
39 lung cancer 10.0
40 endotheliitis 9.9
41 alzheimer disease 9.9
42 neuromyelitis optica 9.9
43 epilepsy 9.9
44 neuroblastoma 9.9
45 breast cancer 9.9
46 pancreatic cancer 9.8
47 aging 9.8
48 colorectal adenoma 9.8
49 cutaneous leishmaniasis 9.8
50 hepatosplenic t-cell lymphoma 9.8

Graphical network of the top 20 diseases related to Isolated Optic Neuritis:



Diseases related to Isolated Optic Neuritis

Symptoms & Phenotypes for Isolated Optic Neuritis

GenomeRNAi Phenotypes related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.62 CNP MBP

Drugs & Therapeutics for Isolated Optic Neuritis

Search Clinical Trials , NIH Clinical Center for Isolated Optic Neuritis

Genetic Tests for Isolated Optic Neuritis

Anatomical Context for Isolated Optic Neuritis

MalaCards organs/tissues related to Isolated Optic Neuritis:

41
Eye, T Cells, Spinal Cord

Publications for Isolated Optic Neuritis

Articles related to Isolated Optic Neuritis:

(show all 21)
# Title Authors Year
1
Isolated optic neuritis associated with Mycoplasma pneumoniae infection: report of two cases and literature review. ( 28321515 )
2017
2
Recurrent isolated optic neuritis: A study on 22 patients. ( 29114368 )
2017
3
Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode. ( 27775238 )
2017
4
Antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and the glycine receptor I+1 subunit in patients with isolated optic neuritis. ( 25506781 )
2015
5
MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study. ( 25749692 )
2015
6
Analysis of spectral domain optical coherence tomography measurements in optic neuritis: differences in neuromyelitis optica, multiple sclerosis, isolated optic neuritis and normal healthy controls. ( 23889747 )
2014
7
Predicting multiple sclerosis following isolated optic neuritis in children. ( 23663558 )
2013
8
Aquaporin-4 antibody negative recurrent isolated optic neuritis: clinical evidence for disease heterogeneity. ( 23735776 )
2013
9
Noninvasive assessments of optic nerve neurodegeneration in transgenic mice with isolated optic neuritis. ( 23722393 )
2013
10
Retinal nerve fibre layer thinning in patients with clinically isolated optic neuritis and early treatment with interferon-beta. ( 23272128 )
2012
11
Isolated optic neuritis secondary to presumed tuberculosis in an immunocompetent child. ( 22582557 )
2012
12
Anti-aquaporin-4 antibody-positive recurrent isolated optic neuritis and primary SjAPgren's syndrome. ( 22327571 )
2012
13
Cognitive dysfunction 24-31 years after isolated optic neuritis. ( 18573827 )
2008
14
Predictive role of evoked potential examinations in patients with clinically isolated optic neuritis in light of the revised McDonald criteria. ( 18208873 )
2008
15
Isolated optic neuritis from an identified Gnathostoma spinigerum. ( 17294395 )
2007
16
Prognosis of Taiwanese patients with isolated optic neuritis after intravenous methylprednisolone pulse therapy. ( 17711799 )
2007
17
Is the frequency of abnormalities on magnetic resonance imaging in isolated optic neuritis related to the prevalence of multiple sclerosis? A global comparison. ( 16788011 )
2006
18
The approach to bilateral simultaneous isolated optic neuritis. ( 16622079 )
2006
19
Immunohistochemical evidence of inducible nitric oxide synthase and nitrotyrosine in a case of clinically isolated optic neuritis. ( 16845306 )
2006
20
Systemic T-cell activation in acute clinically isolated optic neuritis. ( 15833372 )
2005
21
Spinal cord MRI in clinically isolated optic neuritis. ( 14617723 )
2003

Variations for Isolated Optic Neuritis

Expression for Isolated Optic Neuritis

Search GEO for disease gene expression data for Isolated Optic Neuritis.

Pathways for Isolated Optic Neuritis

Pathways related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.69 CNP MBP
2 10.75 CNP MBP
3 9.53 CNP MBP

GO Terms for Isolated Optic Neuritis

Cellular components related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 8.96 CNP MBP
2 myelin sheath GO:0043209 8.62 CNP MBP

Biological processes related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.16 CNP MBP
2 response to toxic substance GO:0009636 8.96 CNP MBP
3 substantia nigra development GO:0021762 8.62 CNP MBP

Sources for Isolated Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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