ION
MCID: ISL119
MIFTS: 26

Isolated Optic Neuritis (ION)

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Isolated Optic Neuritis

MalaCards integrated aliases for Isolated Optic Neuritis:

Name: Isolated Optic Neuritis 58
Ion 58

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases


External Ids:

Orphanet 58 ORPHA499096

Summaries for Isolated Optic Neuritis

MalaCards based summary : Isolated Optic Neuritis, also known as ion, is related to neuritis and multiple sclerosis. An important gene associated with Isolated Optic Neuritis is CNP (2',3'-Cyclic Nucleotide 3' Phosphodiesterase), and among its related pathways/superpathways are Neuroscience and MECP2 and Associated Rett Syndrome. Affiliated tissues include eye, cortex and spinal cord, and related phenotype is Negative genetic interaction between BLM-/- and BLM+/+.

Related Diseases for Isolated Optic Neuritis

Diseases related to Isolated Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1543)
# Related Disease Score Top Affiliating Genes
1 neuritis 30.7 MBP CNP
2 multiple sclerosis 29.5 MBP CNP
3 hyperphenylalaninemia 29.4 MBP CNP
4 oligodendroglioma 28.9 MBP CNP
5 niemann-pick disease 28.9 MBP CNP
6 hypertrophic neuropathy of dejerine-sottas 28.8 MBP CNP
7 metachromatic leukodystrophy 28.7 MBP CNP
8 isolated optic neuritis without anti-mog antibodies 11.4
9 chronic relapsing inflammatory optic neuropathy 11.3
10 triiodothyronine receptor auxiliary protein 11.3
11 short qt syndrome 11.0
12 mucolipidosis iv 11.0
13 long qt syndrome 11.0
14 pseudohypoaldosteronism, type iid 11.0
15 metabolic acidosis 11.0
16 periodic paralysis 10.9
17 episodic ataxia 10.9
18 hyperuricemia 10.9
19 hair whorl 10.9
20 jervell and lange-nielsen syndrome 1 10.9
21 juvenile absence epilepsy 10.9
22 familial periodic paralysis 10.9
23 distal renal tubular acidosis 10.9
24 metatropic dysplasia 10.9
25 dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema 10.9
26 bestrophinopathy, autosomal recessive 10.9
27 bartter syndrome type 4 10.9
28 hypotonia-speech impairment-severe cognitive delay syndrome 10.9
29 hyperaldosteronism, familial, type i 10.8
30 jalili syndrome 10.8
31 rh-null, regulator type 10.8
32 hyperaldosteronism, familial, type ii 10.8
33 qt interval, variation in 10.8
34 nondystrophic myotonia 10.8
35 optic neuritis 10.7
36 rapidly involuting congenital hemangioma 10.7
37 helix syndrome 10.7
38 cystic fibrosis 10.6
39 neuroblastoma 10.5
40 anoxia 10.4
41 hypoxia 10.4
42 glioblastoma 10.4
43 cardiac conduction defect 10.4
44 pancreatic cancer 10.4
45 cholera 10.4
46 chordoma 10.4
47 pertussis 10.4
48 glial tumor 10.4
49 cardiac arrhythmia 10.4
50 glioma 10.4

Graphical network of the top 20 diseases related to Isolated Optic Neuritis:



Diseases related to Isolated Optic Neuritis

Symptoms & Phenotypes for Isolated Optic Neuritis

GenomeRNAi Phenotypes related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.62 CNP MBP

Drugs & Therapeutics for Isolated Optic Neuritis

Search Clinical Trials , NIH Clinical Center for Isolated Optic Neuritis

Genetic Tests for Isolated Optic Neuritis

Anatomical Context for Isolated Optic Neuritis

MalaCards organs/tissues related to Isolated Optic Neuritis:

40
Eye, Cortex, Spinal Cord, B Cells

Publications for Isolated Optic Neuritis

Articles related to Isolated Optic Neuritis:

(show top 50) (show all 138)
# Title Authors PMID Year
1
Defining the disease course of TNFα blockers-associated Multiple Sclerosis. 61
33647875 2021
2
Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder. 61
33276239 2021
3
Clinical Features and Risk of Relapse in Children and Adults with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. 61
32959427 2021
4
Different alteration patterns of sub-macular choroidal thicknesses in aquaporin-4 immunoglobulin G antibodies sero-positive neuromyelitis optica spectrum diseases and isolated optic neuritis. 61
32657009 2020
5
MRI Characteristics of NMO, MOG and MS Related Optic Neuritis. 61
33395326 2020
6
Isolated Optic Neuritis after Pembrolizumab Administration for Non-Small-Cell Lung Carcinoma. 61
32998608 2020
7
Effect of phenytoin on retinal ganglion cells in acute isolated optic neuritis. 61
32212009 2020
8
Longitudinal Development of Peripapillary Hyper-Reflective Ovoid Masslike Structures Suggests a Novel Pathological Pathway in Multiple Sclerosis. 61
32426856 2020
9
Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Associated Disease in Korean Children. 61
32657068 2020
10
A rare pediatric case of neurobrucellosis with bilateral optic neuritis. 61
33372450 2020
11
Vision improvement in severe acute isolated optic neuritis after plasma exchange treatment in Chinese population: a prospective case series study. 61
32913445 2020
12
Clinical Features and Outcomes of Pediatric Monophasic and Recurrent Idiopathic Optic Neuritis. 61
31566057 2020
13
Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event. 61
31432354 2020
14
Central Nervous System Demyelination Associated With Immune Checkpoint Inhibitors: Review of the Literature. 61
33362680 2020
15
Clinical spectrum of inflammatory central nervous system demyelinating disorders associated with antibodies against myelin oligodendrocyte glycoprotein. 61
30365980 2019
16
Epidemiologic and Clinical Characteristics of Optic Neuritis in Japan. 61
31196727 2019
17
Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders. 61
29771186 2019
18
Clinical presentation of optic neuritis with autoantibodies anti-myelin oligodendrocyte glycoprotein. 61
29972029 2019
19
Neurological presentations of Bartonella henselae infection. 61
30368695 2019
20
Should Spinal MRI Be Routinely Performed in Patients With Clinically Isolated Optic Neuritis? 61
30001224 2018
21
Isolated optic neuritis with a concurrent abnormal trigeminal nucleus on imaging: case report of a rare complication of herpes zoster ophthalmicus. 61
30286736 2018
22
Optic neuritis in dogs: 96 cases (1983-2016). 61
29251394 2018
23
Different features between pediatric-onset and adult-onset patients who are seropositive for MOG-IgG: A multicenter study in South China. 61
29957392 2018
24
MRI of the first event in pediatric acquired demyelinating syndromes with antibodies to myelin oligodendrocyte glycoprotein. 61
29423614 2018
25
Prevalence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4-IgG in Patients in the Optic Neuritis Treatment Trial. 61
29470571 2018
26
MOG Spectrum Disorders and Role of MOG-Antibodies in Clinical Practice. 61
28859212 2018
27
Aquaporin 4 Antibody in the Korean Patient with New-Onset Optic Neuritis. 61
27668553 2018
28
Central Nervous System Involvement in Common Variable Immunodeficiency: A Case of Acute Unilateral Optic Neuritis in a 26-Year-Old Italian Patient. 61
30555409 2018
29
Clinical presentation and prognosis in MOG-antibody disease: a UK study. 61
29136091 2017
30
MOG-IgG associated optic neuritis is not multiple sclerosis. 61
29166458 2017
31
Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode. 61
27775238 2017
32
Recurrent isolated optic neuritis: A study on 22 patients. 61
29114368 2017
33
Isolated optic neuritis associated with Mycoplasma pneumoniae infection: report of two cases and literature review. 61
28321515 2017
34
Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients. 61
28738904 2017
35
An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis. 61
28043954 2017
36
Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases. 61
28533781 2017
37
The neuromyelitis optica presentation and the aquaporin-4 antibody in HIV-seropositive and seronegative patients in KwaZulu-Natal, South Africa. 61
29568625 2017
38
Disease Activity and Conversion into Multiple Sclerosis after Optic Neuritis Is Treated with Erythropoietin. 61
27706045 2016
39
Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes. 61
27147513 2016
40
MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study. 61
25749692 2016
41
Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses. 61
26537743 2016
42
Status of diagnostic approaches to AQP4-IgG seronegative NMO and NMO/MS overlap syndromes. 61
26530512 2016
43
Oligoclonal bands predict multiple sclerosis in children with optic neuritis. 61
25820181 2015
44
Antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and the glycine receptor α1 subunit in patients with isolated optic neuritis. 61
25506781 2015
45
Neurogenic vision loss: Causes and outcome. An experience from a tertiary center in Northern India. 61
25288834 2014
46
Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort. 61
24133290 2014
47
Diagnosis and classification of autoimmune optic neuropathy. 61
24424177 2014
48
The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review. 61
24524923 2014
49
Analysis of spectral domain optical coherence tomography measurements in optic neuritis: differences in neuromyelitis optica, multiple sclerosis, isolated optic neuritis and normal healthy controls. 61
23889747 2014
50
Macular spectral domain optical coherence tomography findings in Tanzanian endemic optic neuropathy. 61
24018312 2013

Variations for Isolated Optic Neuritis

Expression for Isolated Optic Neuritis

Search GEO for disease gene expression data for Isolated Optic Neuritis.

Pathways for Isolated Optic Neuritis

Pathways related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.69 MBP CNP
2 10.75 MBP CNP
3 9.53 MBP CNP

GO Terms for Isolated Optic Neuritis

Cellular components related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 8.96 MBP CNP
2 myelin sheath GO:0043209 8.62 MBP CNP

Biological processes related to Isolated Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.16 MBP CNP
2 response to toxic substance GO:0009636 8.96 MBP CNP
3 substantia nigra development GO:0021762 8.62 MBP CNP

Sources for Isolated Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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