MCID: ISN001
MIFTS: 16

Isoniazid Toxicity

Categories: Rare diseases

Aliases & Classifications for Isoniazid Toxicity

MalaCards integrated aliases for Isoniazid Toxicity:

Name: Isoniazid Toxicity 60

Classifications:



External Ids:

Orphanet 60 ORPHA240887

Summaries for Isoniazid Toxicity

MalaCards based summary : Isoniazid Toxicity is related to aceruloplasminemia and metabolic acidosis. An important gene associated with Isoniazid Toxicity is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Affiliated tissues include liver.

Related Diseases for Isoniazid Toxicity

Diseases related to Isoniazid Toxicity via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 aceruloplasminemia 10.0
2 metabolic acidosis 10.0
3 pulmonary tuberculosis 10.0
4 lactic acidosis 10.0
5 bladder cancer 9.9
6 status epilepticus 9.9
7 peripheral nervous system disease 9.9
8 neuropathy 9.9
9 lupus erythematosus 9.9
10 psoriasis 9.9
11 drug-induced hepatitis 9.7 CYP2E1 NAT2
12 methemoglobinemia 9.6 CYP2E1 NAT2
13 alcoholic liver cirrhosis 9.5 CYP2E1 NAT2

Graphical network of the top 20 diseases related to Isoniazid Toxicity:



Diseases related to Isoniazid Toxicity

Symptoms & Phenotypes for Isoniazid Toxicity

Drugs & Therapeutics for Isoniazid Toxicity

Search Clinical Trials , NIH Clinical Center for Isoniazid Toxicity

Genetic Tests for Isoniazid Toxicity

Anatomical Context for Isoniazid Toxicity

MalaCards organs/tissues related to Isoniazid Toxicity:

42
Liver

Publications for Isoniazid Toxicity

Articles related to Isoniazid Toxicity:

(show all 36)
# Title Authors Year
1
Discovery of Novel Enhancers of Isoniazid Toxicity in Mycobacterium tuberculosis. ( 29617279 )
2018
2
Isoniazid toxicity presenting as bilateral dentate hyperintensities. ( 28879938 )
2017
3
Isoniazid toxicity and TB development during biological therapy of patients with psoriasis in Colombia. ( 27003177 )
2016
4
Prevention of isoniazid toxicity by NAT2 genotyping in Senegalese tuberculosis patients. ( 28959610 )
2016
5
An unusual case of isoniazid toxicity. ( 25670661 )
2015
6
Isoniazid Toxicity among an Older Veteran Population: A Retrospective Cohort Study. ( 23365735 )
2013
7
Isoniazid toxicity in a 5-year-old boy. ( 23670154 )
2013
8
Does CYP2E1 play a major role in the aggravation of isoniazid toxicity by rifampicin in human hepatocytes? ( 19371336 )
2009
9
Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( 19753763 )
2009
10
Acute isoniazid toxicity and the need for adequate pyridoxine supplies. ( 16999664 )
2006
11
Hepatoprotective effect of isonicotinoylhydrazone SH7 against chronic isoniazid toxicity. ( 15739904 )
2005
12
Treatment of acute isoniazid toxicity of unknown dose. ( 12602731 )
2003
13
Isoniazid toxicity in health care workers. ( 10825056 )
1999
14
Protective role of the Mycobacterium smegmatis IdeR against reactive oxygen species and isoniazid toxicity. ( 10645447 )
1998
15
Isoniazid toxicity: a survey of pyridoxine availability. ( 8179762 )
1994
16
Isoniazid toxicity with cerebellar ataxia in a child. ( 8439890 )
1993
17
Isoniazid toxicity with cerebellar ataxia in a child. ( 8457941 )
1993
18
Isoniazid toxicity presenting as seizures and metabolic acidosis. ( 2304098 )
1990
19
Acute isoniazid toxicity--report of 2 cases and review of literature. ( 3596852 )
1987
20
Relationship of acetylator status to isoniazid toxicity, lupus erythematosus, and bladder cancer. ( 6628700 )
1983
21
Isoniazid toxicity as a cause of peripheral neuropathy. Case presentation and discussion. ( 6274942 )
1981
22
Isoniazid toxicity. Pyridoxine controlled seizures in a dialysis patient. ( 7310217 )
1981
23
Isoniazid toxicity and pyridoxine. ( 7368325 )
1980
24
Convulsions as the etiology of lactic acidosis in acute isoniazid toxicity in dogs. ( 40324 )
1979
25
Failure of pyruvate to counteract isoniazid toxicity in rabbits. ( 1507 )
1975
26
Treatment of acute isoniazid toxicity. ( 1136966 )
1975
27
Treatment of acute isoniazid toxicity. ( 4447461 )
1974
28
Isoniazid toxicity. Reversal with pyridoxine. ( 4813614 )
1974
29
Editorial: Isoniazid toxicity. ( 4827614 )
1974
30
Isoniazid toxicity. A prospective study in secondary chemoprophylaxis. ( 5067581 )
1972
31
Isoniazid toxicity: reports of lactic acidosis and keratitis. ( 5101723 )
1971
32
Isoniazid toxicity. ( 5109874 )
1971
33
Rheumatic symptoms during tuberculosis therapy. A manifestation of isoniazid toxicity? ( 4158741 )
1965
34
THE PREVENTION AND TREATMENT OF ISONIAZID TOXICITY IN THE THERAPY OF PULMONARY TUBERCULOSIS. 2. AN ASSESSMENT OF THE PROPHYLACTIC EFFECT OF PYRIDOXINE IN LOW DOSAGE. ( 14099673 )
1963
35
The prevention and treatment of isoniazid toxicity in the therapy of pulmonary tuberculosis: 1. An assessment of two vitamin B preparations and glutamic acid. ( 20604148 )
1963
36
Use of pyridoxine hydrochloride to prevent isoniazid toxicity. ( 13575154 )
1958

Variations for Isoniazid Toxicity

Expression for Isoniazid Toxicity

Search GEO for disease gene expression data for Isoniazid Toxicity.

Pathways for Isoniazid Toxicity

Pathways related to Isoniazid Toxicity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 CYP2E1 NAT2
2
Show member pathways
11.68 CYP2E1 NAT2
3
Show member pathways
10.1 CYP2E1 NAT2

GO Terms for Isoniazid Toxicity

Biological processes related to Isoniazid Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 8.62 CYP2E1 NAT2

Sources for Isoniazid Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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