MCID: ISN001
MIFTS: 15

Isoniazid Toxicity

Categories: Rare diseases

Aliases & Classifications for Isoniazid Toxicity

MalaCards integrated aliases for Isoniazid Toxicity:

Name: Isoniazid Toxicity 59

Classifications:



External Ids:

Orphanet 59 ORPHA240887

Summaries for Isoniazid Toxicity

MalaCards based summary : Isoniazid Toxicity is related to aceruloplasminemia and ataxia-oculomotor apraxia 3. An important gene associated with Isoniazid Toxicity is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450.

Related Diseases for Isoniazid Toxicity

Diseases related to Isoniazid Toxicity via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 aceruloplasminemia 9.9
2 ataxia-oculomotor apraxia 3 9.9
3 metabolic acidosis 9.9
4 bladder cancer 9.7
5 status epilepticus 9.7
6 lactic acidosis 9.7
7 peripheral nervous system disease 9.7
8 neuropathy 9.7
9 lupus erythematosus 9.7
10 psoriasis 9.7
11 drug-induced hepatitis 9.3 CYP2E1 NAT2
12 methemoglobinemia 9.2 CYP2E1 NAT2
13 alcoholic liver cirrhosis 9.0 CYP2E1 NAT2

Graphical network of the top 20 diseases related to Isoniazid Toxicity:



Diseases related to Isoniazid Toxicity

Symptoms & Phenotypes for Isoniazid Toxicity

Drugs & Therapeutics for Isoniazid Toxicity

Search Clinical Trials , NIH Clinical Center for Isoniazid Toxicity

Genetic Tests for Isoniazid Toxicity

Anatomical Context for Isoniazid Toxicity

Publications for Isoniazid Toxicity

Articles related to Isoniazid Toxicity:

(show all 25)
# Title Authors Year
1
Discovery of Novel Enhancers of Isoniazid Toxicity in <i>Mycobacterium tuberculosis</i>. ( 29617279 )
2018
2
Isoniazid toxicity presenting as bilateral dentate hyperintensities. ( 28879938 )
2017
3
Isoniazid toxicity and TB development during biological therapy of patients with psoriasis in Colombia. ( 27003177 )
2016
4
Prevention of isoniazid toxicity by NAT2 genotyping in Senegalese tuberculosis patients. ( 28959610 )
2016
5
An unusual case of isoniazid toxicity. ( 25670661 )
2015
6
Isoniazid toxicity in a 5-year-old boy. ( 23670154 )
2013
7
Isoniazid Toxicity among an Older Veteran Population: A Retrospective Cohort Study. ( 23365735 )
2013
8
Does CYP2E1 play a major role in the aggravation of isoniazid toxicity by rifampicin in human hepatocytes? ( 19371336 )
2009
9
Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( 19753763 )
2009
10
Acute isoniazid toxicity and the need for adequate pyridoxine supplies. ( 16999664 )
2006
11
Hepatoprotective effect of isonicotinoylhydrazone SH7 against chronic isoniazid toxicity. ( 15739904 )
2005
12
Treatment of acute isoniazid toxicity of unknown dose. ( 12602731 )
2003
13
Isoniazid toxicity in health care workers. ( 10825056 )
1999
14
Protective role of the Mycobacterium smegmatis IdeR against reactive oxygen species and isoniazid toxicity. ( 10645447 )
1998
15
Isoniazid toxicity: a survey of pyridoxine availability. ( 8179762 )
1994
16
Isoniazid toxicity with cerebellar ataxia in a child. ( 8457941 )
1993
17
Isoniazid toxicity with cerebellar ataxia in a child. ( 8439890 )
1993
18
Isoniazid toxicity presenting as seizures and metabolic acidosis. ( 2304098 )
1990
19
Acute isoniazid toxicity--report of 2 cases and review of literature. ( 3596852 )
1987
20
Relationship of acetylator status to isoniazid toxicity, lupus erythematosus, and bladder cancer. ( 6628700 )
1983
21
Isoniazid toxicity as a cause of peripheral neuropathy. Case presentation and discussion. ( 6274942 )
1981
22
Isoniazid toxicity. Pyridoxine controlled seizures in a dialysis patient. ( 7310217 )
1981
23
Isoniazid toxicity and pyridoxine. ( 7368325 )
1980
24
Convulsions as the etiology of lactic acidosis in acute isoniazid toxicity in dogs. ( 40324 )
1979
25
Failure of pyruvate to counteract isoniazid toxicity in rabbits. ( 1507 )
1975

Variations for Isoniazid Toxicity

Expression for Isoniazid Toxicity

Search GEO for disease gene expression data for Isoniazid Toxicity.

Pathways for Isoniazid Toxicity

Pathways related to Isoniazid Toxicity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 CYP2E1 NAT2
2
Show member pathways
11.65 CYP2E1 NAT2
3
Show member pathways
10.05 CYP2E1 NAT2

GO Terms for Isoniazid Toxicity

Biological processes related to Isoniazid Toxicity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 8.62 CYP2E1 NAT2

Sources for Isoniazid Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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