MCID: ISR001
MIFTS: 23

Israeli Tick Typhus

Categories: Infectious diseases

Aliases & Classifications for Israeli Tick Typhus

MalaCards integrated aliases for Israeli Tick Typhus:

Name: Israeli Tick Typhus 12 15
Israeli Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050043

Summaries for Israeli Tick Typhus

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp israelensis, which is transmitted by ticks (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar, has symptom regional adenopathy, and has symptom maculopapular rash on extremities.

MalaCards based summary : Israeli Tick Typhus, also known as israeli spotted fever, is related to robinow syndrome, autosomal recessive and robinow syndrome, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Israeli Tick Typhus is PLEKHG4 (Pleckstrin Homology And RhoGEF Domain Containing G4), and among its related pathways/superpathways are Immune response IFN gamma signaling pathway and Salmonella infection (KEGG). Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Israeli Tick Typhus

Diseases related to Israeli Tick Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 robinow syndrome, autosomal recessive 10.5 HPSE PLEKHG4
2 robinow syndrome 10.4 HPSE PLEKHG4
3 spotted fever 10.4
4 cowpox 9.9 CASP1 CXCL8
5 shigellosis 9.8 CASP1 CXCL8
6 purpura fulminans 9.8
7 purpura 9.8
8 endotheliitis 9.8
9 osteomyelitis 9.7 CASP1 CXCL8
10 herpes simplex virus keratitis 9.7 CCL2 CXCL8
11 denture stomatitis 9.7 CCL2 CXCL8
12 chlamydia 9.7 CASP1 CXCL8
13 macular holes 9.7 CCL2 CXCL8
14 pleural tuberculosis 9.7 CCL2 CXCL8
15 tuberculous meningitis 9.7 CCL2 CXCL8
16 acute cystitis 9.7 CCL2 CXCL8
17 viral meningitis 9.7 CCL2 CXCL8
18 viral encephalitis 9.7 CCL2 CXCL8
19 pleurisy 9.7 CCL2 CXCL8
20 leptospirosis 9.7 CCL2 CXCL8
21 pyelonephritis 9.6 CCL2 CXCL8
22 severe acute respiratory syndrome 9.6 CCL2 CXCL8
23 extrinsic allergic alveolitis 9.6 CCL2 CXCL8
24 silicosis 9.6 CCL2 CXCL8
25 chorioamnionitis 9.6 CCL2 CXCL8
26 microvascular complications of diabetes 1 9.6 CCL2 CXCL8
27 pneumoconiosis 9.6 CCL2 CXCL8
28 alcoholic hepatitis 9.6 CCL2 CXCL8
29 autoinflammation, lipodystrophy, and dermatosis syndrome 9.6 CCL2 CXCL8
30 bone inflammation disease 9.5 CCL2 CXCL8
31 idiopathic interstitial pneumonia 9.5 CCL2 CXCL8
32 peritonitis 9.4 CCL2 CXCL8
33 respiratory system disease 9.4 CCL2 CXCL8
34 trypanosomiasis 9.4 CCL2 CXCL8
35 endometriosis 9.3 CCL2 CXCL8
36 meningitis 9.2 CCL2 CXCL8
37 chagas disease 9.1 CCL2 CXCL8
38 periodontitis 8.9 CCL2 CXCL8

Graphical network of the top 20 diseases related to Israeli Tick Typhus:



Diseases related to Israeli Tick Typhus

Symptoms & Phenotypes for Israeli Tick Typhus

Symptoms:

12
  • fever
  • eschar
  • regional adenopathy
  • maculopapular rash on extremities

GenomeRNAi Phenotypes related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 ATR CASP1 CXCL8 PLEKHG4
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 PLEKHG4 ATR CASP1 CXCL8

Drugs & Therapeutics for Israeli Tick Typhus

Search Clinical Trials , NIH Clinical Center for Israeli Tick Typhus

Genetic Tests for Israeli Tick Typhus

Anatomical Context for Israeli Tick Typhus

Publications for Israeli Tick Typhus

Articles related to Israeli Tick Typhus:

# Title Authors Year
1
Rickettsia conorii Israeli tick typhus strain isolated from Rhipicephalus sanguineus ticks in Portugal. ( 17767403 )
2007

Variations for Israeli Tick Typhus

Expression for Israeli Tick Typhus

Search GEO for disease gene expression data for Israeli Tick Typhus.

Pathways for Israeli Tick Typhus

Pathways related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 CASP1 CCL2 CXCL8
2 11.39 CASP1 CXCL8
3 11.31 CASP1 CXCL8
4 11.17 CCL2 CXCL8
5
Show member pathways
11.08 CCL2 CXCL8
6 11 CASP1 CXCL8
7 10.85 CCL2 CXCL8
8 10.65 CCL2 CXCL8
9 10.15 CCL2 CXCL8

GO Terms for Israeli Tick Typhus

Biological processes related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.5 CASP1 CCL2 CXCL8
2 cellular response to interleukin-1 GO:0071347 9.43 CCL2 CXCL8
3 chemokine-mediated signaling pathway GO:0070098 9.4 CCL2 CXCL8
4 neutrophil chemotaxis GO:0030593 9.37 CCL2 CXCL8
5 response to bacterium GO:0009617 9.26 CASP1 CCL2
6 cellular response to fibroblast growth factor stimulus GO:0044344 9.16 CCL2 CXCL8
7 cellular response to lipopolysaccharide GO:0071222 9.13 CASP1 CCL2 CXCL8
8 PERK-mediated unfolded protein response GO:0036499 8.62 CCL2 CXCL8

Molecular functions related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CCL2 CXCL8

Sources for Israeli Tick Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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