MCID: ISR001
MIFTS: 26

Israeli Tick Typhus

Categories: Infectious diseases

Aliases & Classifications for Israeli Tick Typhus

MalaCards integrated aliases for Israeli Tick Typhus:

Name: Israeli Tick Typhus 12 15
Israeli Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050043

Summaries for Israeli Tick Typhus

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp israelensis, which is transmitted by ticks (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar, has symptom regional adenopathy, and has symptom maculopapular rash on extremities.

MalaCards based summary : Israeli Tick Typhus, also known as israeli spotted fever, is related to spotted fever and robinow syndrome, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Israeli Tick Typhus is PLEKHG4 (Pleckstrin Homology And RhoGEF Domain Containing G4), and among its related pathways/superpathways are Immune response IFN gamma signaling pathway and Salmonella infection (KEGG). Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Israeli Tick Typhus

Diseases related to Israeli Tick Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 spotted fever 10.6
2 robinow syndrome 10.2 HPSE PLEKHG4
3 robinow syndrome, autosomal recessive 10.2 HPSE PLEKHG4
4 japanese spotted fever 10.1 CCL2 PLEKHG4
5 cowpox 9.9 CASP1 CXCL8
6 arthritis 9.9
7 purpura fulminans 9.9
8 purpura 9.9
9 shigellosis 9.9 CASP1 CXCL8
10 herpes simplex virus keratitis 9.9 CCL2 CXCL8
11 denture stomatitis 9.9 CCL2 CXCL8
12 placenta disease 9.9 ANXA5 CXCL8
13 viral meningitis 9.8 CCL2 CXCL8
14 meningitis 9.8 CCL2 CXCL8
15 bacteriuria 9.8 CCL2 CXCL8
16 pleural tuberculosis 9.8 CCL2 CXCL8
17 macular holes 9.8 CCL2 CXCL8
18 chlamydia 9.8 CASP1 CXCL8
19 tuberculous meningitis 9.8 CCL2 CXCL8
20 acute cystitis 9.8 CCL2 CXCL8
21 cystitis 9.8 CCL2 CXCL8
22 viral encephalitis 9.8 CCL2 CXCL8
23 pleurisy 9.8 CCL2 CXCL8
24 pyelonephritis 9.8 CCL2 CXCL8
25 leptospirosis 9.8 CCL2 CXCL8
26 severe acute respiratory syndrome 9.8 CCL2 CXCL8
27 silicosis 9.8 CCL2 CXCL8
28 extrinsic allergic alveolitis 9.8 CCL2 CXCL8
29 pneumoconiosis 9.8 CCL2 CXCL8
30 chorioamnionitis 9.8 CCL2 CXCL8
31 alcoholic hepatitis 9.8 CCL2 CXCL8
32 idiopathic interstitial pneumonia 9.8 CCL2 CXCL8
33 bone inflammation disease 9.8 CCL2 CXCL8
34 cytomegalovirus infection 9.7 CCL2 CXCL8
35 peritonitis 9.7 CCL2 CXCL8
36 trypanosomiasis 9.7 CCL2 CXCL8
37 proteasome-associated autoinflammatory syndrome 1 9.7 CCL2 CXCL8
38 chagas disease 9.7 CCL2 CXCL8
39 periodontitis 9.6 CCL2 CXCL8
40 bacterial infectious disease 9.6 CASP1 CCL2 CXCL8
41 endometrial stromal sarcoma 9.6 CCL2 CXCL8
42 microvascular complications of diabetes 1 9.4 CCL2 CXCL8

Graphical network of the top 20 diseases related to Israeli Tick Typhus:



Diseases related to Israeli Tick Typhus

Symptoms & Phenotypes for Israeli Tick Typhus

Symptoms:

12
  • fever
  • eschar
  • regional adenopathy
  • maculopapular rash on extremities

GenomeRNAi Phenotypes related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 ATR CASP1 CXCL8 PLEKHG4
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 ATR CASP1 CXCL8 PLEKHG4

Drugs & Therapeutics for Israeli Tick Typhus

Search Clinical Trials , NIH Clinical Center for Israeli Tick Typhus

Genetic Tests for Israeli Tick Typhus

Anatomical Context for Israeli Tick Typhus

Publications for Israeli Tick Typhus

Articles related to Israeli Tick Typhus:

# Title Authors Year
1
Israeli Spotted Fever in Sicily. Description of two cases and minireview. ( 28408252 )
2017
2
Rickettsia conorii Israeli tick typhus strain isolated from Rhipicephalus sanguineus ticks in Portugal. ( 17767403 )
2007
3
Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, 'Israeli spotted fever group rickettsia' and Coxiella burnetii. ( 9222041 )
1997
4
Arthritis in Israeli spotted fever. ( 8549102 )
1995
5
Fatal Israeli spotted fever in children. ( 8286624 )
1993
6
Antigenic polypeptides of Israeli spotted fever isolates compared with other spotted fever group rickettsiae. ( 2378464 )
1990
7
Relapse of Israeli spotted fever treated with doxycycline. ( 3838833 )
1985

Variations for Israeli Tick Typhus

Expression for Israeli Tick Typhus

Search GEO for disease gene expression data for Israeli Tick Typhus.

Pathways for Israeli Tick Typhus

Pathways related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.56 CASP1 CCL2 CXCL8
2 11.39 CASP1 CXCL8
3 11.31 CASP1 CXCL8
4 11.2 CCL2 CXCL8
5
Show member pathways
11.08 CCL2 CXCL8
6 11 CASP1 CXCL8
7 10.85 CCL2 CXCL8
8 10.65 CCL2 CXCL8
9 10.15 CCL2 CXCL8

GO Terms for Israeli Tick Typhus

Biological processes related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.43 CASP1 CCL2 CXCL8
2 neutrophil chemotaxis GO:0030593 9.4 CCL2 CXCL8
3 cellular response to interleukin-1 GO:0071347 9.37 CCL2 CXCL8
4 chemokine-mediated signaling pathway GO:0070098 9.32 CCL2 CXCL8
5 cellular response to fibroblast growth factor stimulus GO:0044344 9.16 CCL2 CXCL8
6 cellular response to lipopolysaccharide GO:0071222 9.13 CASP1 CCL2 CXCL8
7 PERK-mediated unfolded protein response GO:0036499 8.62 CCL2 CXCL8

Molecular functions related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CCL2 CXCL8

Sources for Israeli Tick Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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