MCID: ISR001
MIFTS: 29

Israeli Tick Typhus

Categories: Infectious diseases

Aliases & Classifications for Israeli Tick Typhus

MalaCards integrated aliases for Israeli Tick Typhus:

Name: Israeli Tick Typhus 12 15
Israeli Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050043

Summaries for Israeli Tick Typhus

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp israelensis, which is transmitted by ticks (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar, has symptom regional adenopathy, and has symptom maculopapular rash on extremities.

MalaCards based summary : Israeli Tick Typhus, also known as israeli spotted fever, is related to spotted fever and robinow syndrome, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Israeli Tick Typhus is PLEKHG4 (Pleckstrin Homology And RhoGEF Domain Containing G4), and among its related pathways/superpathways are Immune response IFN gamma signaling pathway and Salmonella infection (KEGG). Affiliated tissues include endothelial, bone and placenta, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Israeli Tick Typhus

Diseases related to Israeli Tick Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 spotted fever 10.6
2 robinow syndrome 10.2 HPSE PLEKHG4
3 robinow syndrome, autosomal recessive 10.2 HPSE PLEKHG4
4 japanese spotted fever 10.1 CCL2 PLEKHG4
5 epidemic typhus 10.1
6 cowpox 9.9 CASP1 CXCL8
7 arthritis 9.9
8 purpura fulminans 9.9
9 purpura 9.9
10 shigellosis 9.9 CASP1 CXCL8
11 herpes simplex virus keratitis 9.9 CCL2 CXCL8
12 denture stomatitis 9.9 CCL2 CXCL8
13 placenta disease 9.9 ANXA5 CXCL8
14 viral meningitis 9.9 CCL2 CXCL8
15 meningitis 9.9 CCL2 CXCL8
16 bacteriuria 9.8 CCL2 CXCL8
17 pleural tuberculosis 9.8 CCL2 CXCL8
18 macular holes 9.8 CCL2 CXCL8
19 chlamydia 9.8 CASP1 CXCL8
20 tuberculous meningitis 9.8 CCL2 CXCL8
21 acute cystitis 9.8 CCL2 CXCL8
22 cystitis 9.8 CCL2 CXCL8
23 viral encephalitis 9.8 CCL2 CXCL8
24 pleurisy 9.8 CCL2 CXCL8
25 pyelonephritis 9.8 CCL2 CXCL8
26 leptospirosis 9.8 CCL2 CXCL8
27 severe acute respiratory syndrome 9.8 CCL2 CXCL8
28 silicosis 9.8 CCL2 CXCL8
29 extrinsic allergic alveolitis 9.8 CCL2 CXCL8
30 pneumoconiosis 9.8 CCL2 CXCL8
31 chorioamnionitis 9.8 CCL2 CXCL8
32 alcoholic hepatitis 9.8 CCL2 CXCL8
33 idiopathic interstitial pneumonia 9.8 CCL2 CXCL8
34 bone inflammation disease 9.8 CCL2 CXCL8
35 cytomegalovirus infection 9.7 CCL2 CXCL8
36 peritonitis 9.7 CCL2 CXCL8
37 trypanosomiasis 9.7 CCL2 CXCL8
38 proteasome-associated autoinflammatory syndrome 1 9.7 CCL2 CXCL8
39 chagas disease 9.7 CCL2 CXCL8
40 periodontitis 9.6 CCL2 CXCL8
41 bacterial infectious disease 9.6 CASP1 CCL2 CXCL8
42 endometrial stromal sarcoma 9.6 CCL2 CXCL8
43 microvascular complications of diabetes 1 9.4 CCL2 CXCL8

Graphical network of the top 20 diseases related to Israeli Tick Typhus:



Diseases related to Israeli Tick Typhus

Symptoms & Phenotypes for Israeli Tick Typhus

Symptoms:

12
  • fever
  • eschar
  • regional adenopathy
  • maculopapular rash on extremities

GenomeRNAi Phenotypes related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 ATR CASP1 CXCL8 PLEKHG4
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 ATR CASP1 CXCL8 PLEKHG4

Drugs & Therapeutics for Israeli Tick Typhus

Search Clinical Trials , NIH Clinical Center for Israeli Tick Typhus

Genetic Tests for Israeli Tick Typhus

Anatomical Context for Israeli Tick Typhus

MalaCards organs/tissues related to Israeli Tick Typhus:

42
Endothelial, Bone, Placenta

Publications for Israeli Tick Typhus

Articles related to Israeli Tick Typhus:

(show all 19)
# Title Authors Year
1
Two Cases of Israeli Spotted Fever with Purpura Fulminans, Sharon District, Israel. ( 29664383 )
2018
2
Israeli Spotted Fever in Sicily. Description of two cases and minireview. ( 28408252 )
2017
3
Severe Israeli spotted fever with multiorgan failure in a child. ( 26905298 )
2016
4
Rickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses. ( 26394396 )
2015
5
Genome sequence of Rickettsia conorii subsp. israelensis, the agent of Israeli spotted fever. ( 22933760 )
2012
6
Israeli spotted fever, Tunisia. ( 21762610 )
2011
7
Fatal Israeli spotted fever in a UK traveler to South Portugal. ( 18346246 )
2008
8
Fatal case of Israeli spotted fever after Mediterranean cruise. ( 19046528 )
2008
9
Rickettsia conorii Israeli tick typhus strain isolated from Rhipicephalus sanguineus ticks in Portugal. ( 17767403 )
2007
10
Presence of Rickettsia conorii subsp. israelensis, the causative agent of Israeli spotted fever, in Sicily, Italy, ascertained in a retrospective study. ( 16333093 )
2005
11
The presence of eschars, but not greater severity, in Portuguese patients infected with Israeli spotted fever. ( 16481514 )
2005
12
Israeli spotted fever Rickettsia in Sicilian Rhipicephalus sanguineus ticks. ( 12899144 )
2003
13
Glucose-6-phosphate dehydrogenase deficiency: possible determinant for a fulminant course of Israeli spotted fever. ( 11344735 )
2000
14
Israeli spotted fever rickettsia (Rickettsia conorii complex) associated with human disease in Portugal. ( 10603225 )
1999
15
Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, 'Israeli spotted fever group rickettsia' and Coxiella burnetii. ( 9222041 )
1997
16
Arthritis in Israeli spotted fever. ( 8549102 )
1995
17
Fatal Israeli spotted fever in children. ( 8286624 )
1993
18
Antigenic polypeptides of Israeli spotted fever isolates compared with other spotted fever group rickettsiae. ( 2378464 )
1990
19
Relapse of Israeli spotted fever treated with doxycycline. ( 3838833 )
1985

Variations for Israeli Tick Typhus

Expression for Israeli Tick Typhus

Search GEO for disease gene expression data for Israeli Tick Typhus.

Pathways for Israeli Tick Typhus

Pathways related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.56 CASP1 CCL2 CXCL8
2 11.39 CASP1 CXCL8
3 11.31 CASP1 CXCL8
4 11.2 CCL2 CXCL8
5
Show member pathways
11.08 CCL2 CXCL8
6 11 CASP1 CXCL8
7 10.85 CCL2 CXCL8
8 10.65 CCL2 CXCL8
9 10.15 CCL2 CXCL8

GO Terms for Israeli Tick Typhus

Biological processes related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.43 CASP1 CCL2 CXCL8
2 neutrophil chemotaxis GO:0030593 9.4 CCL2 CXCL8
3 cellular response to interleukin-1 GO:0071347 9.37 CCL2 CXCL8
4 chemokine-mediated signaling pathway GO:0070098 9.32 CCL2 CXCL8
5 cellular response to fibroblast growth factor stimulus GO:0044344 9.16 CCL2 CXCL8
6 cellular response to lipopolysaccharide GO:0071222 9.13 CASP1 CCL2 CXCL8
7 PERK-mediated unfolded protein response GO:0036499 8.62 CCL2 CXCL8

Molecular functions related to Israeli Tick Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CCL2 CXCL8

Sources for Israeli Tick Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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