MCID: IST001
MIFTS: 17

Isthmus Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Isthmus Cancer

MalaCards integrated aliases for Isthmus Cancer:

Name: Isthmus Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9459
ICD9CM 34 182.1
UMLS 71 C0153575

Summaries for Isthmus Cancer

MalaCards based summary : Isthmus Cancer is related to microinvasive cervical squamous cell carcinoma and bleeding disorder, platelet-type, 17. An important gene associated with Isthmus Cancer is INSM1 (INSM Transcriptional Repressor 1), and among its related pathways/superpathways is Reelin Pathway (Cajal-Retzius cells). Affiliated tissues include cervix and uterus, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Isthmus Cancer

Graphical network of the top 20 diseases related to Isthmus Cancer:



Diseases related to Isthmus Cancer

Symptoms & Phenotypes for Isthmus Cancer

GenomeRNAi Phenotypes related to Isthmus Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.53 MAPK8IP1 PTPRN
2 Decreased viability GR00221-A-2 9.53 MAPK8IP2
3 Decreased viability GR00221-A-4 9.53 MAPK8IP1
4 Decreased viability GR00301-A 9.53 MAPK8IP1
5 Decreased viability GR00342-S-1 9.53 MAPK8IP2
6 Decreased viability GR00342-S-3 9.53 MAPK8IP1 MAPK8IP2
7 Decreased viability GR00402-S-2 9.53 MAPK8IP1 MAPK8IP2 PTPRN

MGI Mouse Phenotypes related to Isthmus Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.26 INSM1 MAPK8IP1 MAPK8IP2 PTPRN
2 taste/olfaction MP:0005394 8.62 INSM1 MAPK8IP2

Drugs & Therapeutics for Isthmus Cancer

Search Clinical Trials , NIH Clinical Center for Isthmus Cancer

Genetic Tests for Isthmus Cancer

Anatomical Context for Isthmus Cancer

MalaCards organs/tissues related to Isthmus Cancer:

40
Cervix, Uterus

Publications for Isthmus Cancer

Variations for Isthmus Cancer

Expression for Isthmus Cancer

Search GEO for disease gene expression data for Isthmus Cancer.

Pathways for Isthmus Cancer

Pathways related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 MAPK8IP2 MAPK8IP1

GO Terms for Isthmus Cancer

Biological processes related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of canonical Wnt signaling pathway GO:0090090 9.26 MAPK8IP2 MAPK8IP1
2 receptor-mediated endocytosis GO:0006898 9.16 MAPK8IP2 MAPK8IP1
3 positive regulation of endocytosis GO:0045807 8.96 MAPK8IP2 MAPK8IP1
4 regulation of JNK cascade GO:0046328 8.62 MAPK8IP2 MAPK8IP1

Molecular functions related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinesin binding GO:0019894 8.96 MAPK8IP2 MAPK8IP1
2 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP2 MAPK8IP1

Sources for Isthmus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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