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MCID: IST001
MIFTS: 17

Isthmus Cancer

Categories: Cancer diseases, Reproductive diseases
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Genes Related diseases
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Aliases & Classifications for Isthmus Cancer

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MalaCards integrated aliases for Isthmus Cancer:

Name: Isthmus Cancer 11 14

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:9459
ICD9CM 34 182.1
UMLS 71 C0153575
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Summaries for Isthmus Cancer

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MalaCards based summary: Isthmus Cancer is related to papillary squamous carcinoma and microinvasive cervical squamous cell carcinoma. An important gene associated with Isthmus Cancer is TIMM8A (Translocase Of Inner Mitochondrial Membrane 8A), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Cell adhesion_Cell-matrix glycoconjugates. Related phenotypes are nervous system and endocrine/exocrine gland
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Related Diseases for Isthmus Cancer

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Diseases related to Isthmus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 papillary squamous carcinoma 10.2 MAPK8IP1 INSM1
2 microinvasive cervical squamous cell carcinoma 10.2 PTPRN INSM1
3 vaginal cancer 10.2 MAPK8IP1 INSM1
4 fallopian tube endometrioid adenocarcinoma 10.1 PTPRN INSM1
5 cervical adenosquamous carcinoma 10.1 PTPRN MAPK8IP1
6 endocervical carcinoma 10.1 MAPK8IP1 INSM1
7 pancreatic cystadenoma 10.1 PTPRN INSM1
8 vulvar keratinizing squamous cell carcinoma 10.1 TG LGALS3
9 colloid adenoma 10.1 TG LGALS3
10 heart leiomyosarcoma 10.1 TG LGALS3
11 malignant struma ovarii 10.0 TG LGALS3
12 endocervical adenocarcinoma 10.0 MAPK8IP1 INSM1
13 adrenal cortical hypofunction 10.0 TG PTPRN
14 postsurgical hypothyroidism 10.0 TG PTH
15 hemometra 10.0 PTPRN MAPK8IP1 INSM1
16 pernicious anemia 10.0 TG PTPRN
17 lymphocele 10.0 PTPRN MAPK8IP1 INSM1
18 cervical incompetence 10.0 PTPRN MAPK8IP1 INSM1
19 uterus carcinoma in situ 10.0 PTPRN MAPK8IP1 INSM1
20 cervix uteri carcinoma in situ 10.0 PTPRN MAPK8IP1 INSM1
21 adenocarcinoma in situ 10.0 PTPRN MAPK8IP1 INSM1
22 adenosquamous carcinoma 10.0 PTPRN MAPK8IP1 INSM1
23 tetanic cataract 10.0 PTH CALCA
24 malignant ovarian brenner tumor 10.0 PTH CALCA
25 thyroid angiosarcoma 10.0 TG CALCA
26 suppurative thyroiditis 10.0 TG CALCA
27 spindle epithelial tumor with thymus-like differentiation tumor 10.0 TG CALCA
28 atypical follicular adenoma 10.0 TG CALCA
29 papillary thyroid microcarcinoma 10.0 TG CALCA
30 thyroid sarcoma 10.0 TG CALCA
31 kohler's disease 10.0 PTH CALCA
32 fetal adenoma 10.0 TG CALCA
33 nonencapsulated sclerosing carcinoma 10.0 TG CALCA
34 acute thyroiditis 10.0 TG CALCA
35 epithelial malignant thymoma 10.0 TG CALCA
36 ectopic thymus 10.0 TG CALCA
37 cervix carcinoma 10.0 PTPRN MAPK8IP1 INSM1
38 hypothyroidism, congenital, nongoitrous, 1 10.0 TG PTH
39 hypervitaminosis d 10.0 PTH CALCA
40 urinary bladder small cell neuroendocrine carcinoma 10.0 NCAM1 INSM1
41 thyroid lymphoma 10.0 TG CALCA
42 hypercalcemia, infantile, 1 10.0 PTH CALCA
43 gorham's disease 10.0 PTH CALCA
44 pulmonary large cell neuroendocrine carcinoma 10.0 NCAM1 INSM1
45 large cell neuroendocrine carcinoma 10.0 NCAM1 INSM1
46 thyroid dyshormonogenesis 2a 9.9 TG CALCA
47 horner's syndrome 9.9 TG CALCA
48 cervix small cell carcinoma 9.9 NCAM1 MAPK8IP1
49 bursitis 9.9 PTH CALCA
50 basaloid squamous cell carcinoma 9.9 NCAM1 INSM1

Graphical network of the top 20 diseases related to Isthmus Cancer:



Diseases related to Isthmus Cancer
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Symptoms & Phenotypes for Isthmus Cancer

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MGI Mouse Phenotypes related to Isthmus Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.5 CALCA INSM1 LGALS3 LYZ MAPK8IP1 NCAM1
2 endocrine/exocrine gland MP:0005379 9.17 INSM1 LGALS3 LYZ MAPK8IP1 PTH PTPRN
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Drugs & Therapeutics for Isthmus Cancer

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Search Clinical Trials, NIH Clinical Center for Isthmus Cancer

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Genetic Tests for Isthmus Cancer

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Anatomical Context for Isthmus Cancer

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Publications for Isthmus Cancer

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Variations for Isthmus Cancer

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Expression for Isthmus Cancer

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Search GEO for disease gene expression data for Isthmus Cancer.
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Pathways for Isthmus Cancer

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Pathways related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.81 PTH CALCA
2
Cell adhesion_Cell-matrix glycoconjugates 22
10.55 NCAM1 LGALS3
3
Regucalcin in proximal tubule epithelial kidney cells 74
9.97 PTH CALCA
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GO Terms for Isthmus Cancer

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Molecular functions related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 TG PTH CALCA
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Sources for Isthmus Cancer

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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