Isthmus Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Isthmus Cancer

MalaCards integrated aliases for Isthmus Cancer:

Name: Isthmus Cancer ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9459

ICD9CM ³⁴ 182.1

UMLS ⁷¹ C0153575

Sources

Summaries for Isthmus Cancer

MalaCards based summary : Isthmus Cancer is related to cervical carcinosarcoma and microinvasive cervical squamous cell carcinoma. An important gene associated with Isthmus Cancer is TIMM8A (Translocase Of Inner Mitochondrial Membrane 8A), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates. Related phenotypes are Decreased viability and Decreased viability

Sources

Related Diseases for Isthmus Cancer

Diseases related to Isthmus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)

#	Related Disease	Score	Top Affiliating Genes
1	cervical carcinosarcoma	10.2	MAPK8IP2 MAPK8IP1
2	microinvasive cervical squamous cell carcinoma	10.2	PTPRN INSM1
3	radiation cystitis	10.2	MAPK8IP2 MAPK8IP1
4	bleeding disorder, platelet-type, 17	10.2	PTPRN INSM1
5	cervix small cell carcinoma	10.2	MAPK8IP2 MAPK8IP1
6	sigmoid disease	10.2	MAPK8IP2 MAPK8IP1
7	cervical adenosquamous carcinoma	10.2	MAPK8IP2 MAPK8IP1
8	urinary bladder small cell neuroendocrine carcinoma	10.2	NCAM1 INSM1
9	fallopian tube endometrioid adenocarcinoma	10.1	PTPRN INSM1
10	vaginal discharge	10.1	MAPK8IP2 MAPK8IP1
11	prostate stromal sarcoma	10.1	TIMM8A NCAM1
12	endocervical carcinoma	10.1	MAPK8IP1 INSM1
13	papillary squamous carcinoma	10.0	MAPK8IP2 MAPK8IP1 INSM1
14	vaginal cancer	10.0	MAPK8IP2 MAPK8IP1 INSM1
15	malignant struma ovarii	10.0	TG LGALS3
16	colloid adenoma	10.0	TG LGALS3
17	papillary thymic adenocarcinoma	10.0	TG NCAM1
18	hemometra	9.9	PTPRN MAPK8IP1 INSM1
19	cervical incompetence	9.9	PTPRN MAPK8IP1 INSM1
20	uterus carcinoma in situ	9.9	PTPRN MAPK8IP1 INSM1
21	cervix uteri carcinoma in situ	9.9	PTPRN MAPK8IP1 INSM1
22	tall cell variant papillary carcinoma	9.9	TG LGALS3
23	ovarian germ cell teratoma	9.9	TG LGALS3
24	endometrial small cell carcinoma	9.9	TG NCAM1
25	ovarian serous adenofibroma	9.9	TG NCAM1
26	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	9.9	TG PTPRN
27	ovarian serous cystadenofibroma	9.9	TG NCAM1
28	adrenal cortical hypofunction	9.9	TG PTPRN
29	pernicious anemia	9.8	TG PTPRN
30	hypothyroidism, congenital, nongoitrous, 2	9.8	TG LGALS3
31	ureter small cell carcinoma	9.8	NCAM1 CALCA
32	laryngeal neuroendocrine tumor	9.8	NCAM1 CALCA
33	thyroid tumor	9.8	TG LGALS3
34	thyroid gland mucoepidermoid carcinoma	9.8	TG CALCA
35	colon neuroendocrine neoplasm	9.8	NCAM1 CALCA
36	spindle epithelial tumor with thymus-like differentiation tumor	9.8	TG CALCA
37	atypical follicular adenoma	9.7	TG CALCA
38	substernal goiter	9.7	TG CALCA
39	thyroid sarcoma	9.7	TG CALCA
40	fetal adenoma	9.7	TG CALCA
41	nonencapsulated sclerosing carcinoma	9.7	TG CALCA
42	acute thyroiditis	9.7	TG CALCA
43	thyroiditis	9.7	TG CALCA
44	carotid body cancer	9.7	TG CALCA
45	epithelial malignant thymoma	9.7	TG CALCA
46	dendritic cell thymoma	9.7	TG CALCA
47	ectopic thymus	9.7	TG CALCA
48	thyroid angiosarcoma	9.7	TG CALCA
49	thyroid lymphoma	9.7	TG CALCA
50	papillary thyroid microcarcinoma	9.7	TG CALCA

Graphical network of the top 20 diseases related to Isthmus Cancer:

Sources

Symptoms & Phenotypes for Isthmus Cancer

GenomeRNAi Phenotypes related to Isthmus Cancer according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00173-A	9.23	MAPK8IP1 PTPRN
2	Decreased viability	GR00221-A-4	9.23	MAPK8IP1
3	Decreased viability	GR00249-S	9.23	PTPRN
4	Decreased viability	GR00301-A	9.23	MAPK8IP1
5	Decreased viability	GR00342-S-3	9.23	MAPK8IP1
6	Decreased viability	GR00386-A-1	9.23	MAPK8IP1
7	Decreased viability	GR00402-S-2	9.23	MAPK8IP1

Sources

Drugs & Therapeutics for Isthmus Cancer

Search Clinical Trials , NIH Clinical Center for Isthmus Cancer

Sources

Genetic Tests for Isthmus Cancer

Sources

Anatomical Context for Isthmus Cancer

Sources

Publications for Isthmus Cancer

Sources

Genes for Isthmus Cancer

Genes related to Isthmus Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TIMM8A	Translocase Of Inner Mitochondrial Membrane 8A	Protein Coding	5.51	DISEASES inferred ¹⁵
2	INSM1	INSM Transcriptional Repressor 1	Protein Coding	5.13	DISEASES inferred ¹⁵
3	MAPK8IP2	Mitogen-Activated Protein Kinase 8 Interacting Protein 2	Protein Coding	4.94	DISEASES inferred ¹⁵
4	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	4.84	DISEASES inferred ¹⁵
5	PTPRN	Protein Tyrosine Phosphatase Receptor Type N	Protein Coding	4.64	DISEASES inferred ¹⁵
6	LGALS3	Galectin 3	Protein Coding	4.28	DISEASES inferred ¹⁵
7	TG	Thyroglobulin	Protein Coding	4.07	DISEASES inferred ¹⁵
8	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	3.82	DISEASES inferred ¹⁵
9	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	3.8	DISEASES inferred ¹⁵

Sources

Variations for Isthmus Cancer

Sources

Expression for Isthmus Cancer

Search GEO for disease gene expression data for Isthmus Cancer.

Sources

Pathways for Isthmus Cancer

Pathways related to Isthmus Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cell adhesion_Cell-matrix glycoconjugates ²²	10.21	NCAM1 LGALS3

Sources

GO Terms for Isthmus Cancer

Biological processes related to Isthmus Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	monocyte chemotaxis	GO:0002548	9.16	LGALS3 CALCA
2	positive regulation of endocytosis	GO:0045807	8.96	MAPK8IP2 MAPK8IP1
3	regulation of JNK cascade	GO:0046328	8.62	MAPK8IP2 MAPK8IP1

Molecular functions related to Isthmus Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinesin binding	GO:0019894	8.96	MAPK8IP2 MAPK8IP1
2	MAP-kinase scaffold activity	GO:0005078	8.62	MAPK8IP2 MAPK8IP1

Sources

Sources for Isthmus Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia