MCID: IST001
MIFTS: 16

Isthmus Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Isthmus Cancer

MalaCards integrated aliases for Isthmus Cancer:

Name: Isthmus Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9459
ICD9CM 34 182.1
UMLS 71 C0153575

Summaries for Isthmus Cancer

MalaCards based summary : Isthmus Cancer is related to cervical carcinosarcoma and microinvasive cervical squamous cell carcinoma. An important gene associated with Isthmus Cancer is TIMM8A (Translocase Of Inner Mitochondrial Membrane 8A), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Isthmus Cancer

Diseases related to Isthmus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 cervical carcinosarcoma 10.2 MAPK8IP2 MAPK8IP1
2 microinvasive cervical squamous cell carcinoma 10.2 PTPRN INSM1
3 radiation cystitis 10.2 MAPK8IP2 MAPK8IP1
4 bleeding disorder, platelet-type, 17 10.2 PTPRN INSM1
5 cervix small cell carcinoma 10.2 MAPK8IP2 MAPK8IP1
6 sigmoid disease 10.2 MAPK8IP2 MAPK8IP1
7 cervical adenosquamous carcinoma 10.2 MAPK8IP2 MAPK8IP1
8 urinary bladder small cell neuroendocrine carcinoma 10.2 NCAM1 INSM1
9 fallopian tube endometrioid adenocarcinoma 10.1 PTPRN INSM1
10 vaginal discharge 10.1 MAPK8IP2 MAPK8IP1
11 prostate stromal sarcoma 10.1 TIMM8A NCAM1
12 endocervical carcinoma 10.1 MAPK8IP1 INSM1
13 papillary squamous carcinoma 10.0 MAPK8IP2 MAPK8IP1 INSM1
14 vaginal cancer 10.0 MAPK8IP2 MAPK8IP1 INSM1
15 malignant struma ovarii 10.0 TG LGALS3
16 colloid adenoma 10.0 TG LGALS3
17 papillary thymic adenocarcinoma 10.0 TG NCAM1
18 hemometra 9.9 PTPRN MAPK8IP1 INSM1
19 cervical incompetence 9.9 PTPRN MAPK8IP1 INSM1
20 uterus carcinoma in situ 9.9 PTPRN MAPK8IP1 INSM1
21 cervix uteri carcinoma in situ 9.9 PTPRN MAPK8IP1 INSM1
22 tall cell variant papillary carcinoma 9.9 TG LGALS3
23 ovarian germ cell teratoma 9.9 TG LGALS3
24 endometrial small cell carcinoma 9.9 TG NCAM1
25 ovarian serous adenofibroma 9.9 TG NCAM1
26 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 TG PTPRN
27 ovarian serous cystadenofibroma 9.9 TG NCAM1
28 adrenal cortical hypofunction 9.9 TG PTPRN
29 pernicious anemia 9.8 TG PTPRN
30 hypothyroidism, congenital, nongoitrous, 2 9.8 TG LGALS3
31 ureter small cell carcinoma 9.8 NCAM1 CALCA
32 laryngeal neuroendocrine tumor 9.8 NCAM1 CALCA
33 thyroid tumor 9.8 TG LGALS3
34 thyroid gland mucoepidermoid carcinoma 9.8 TG CALCA
35 colon neuroendocrine neoplasm 9.8 NCAM1 CALCA
36 spindle epithelial tumor with thymus-like differentiation tumor 9.8 TG CALCA
37 atypical follicular adenoma 9.7 TG CALCA
38 substernal goiter 9.7 TG CALCA
39 thyroid sarcoma 9.7 TG CALCA
40 fetal adenoma 9.7 TG CALCA
41 nonencapsulated sclerosing carcinoma 9.7 TG CALCA
42 acute thyroiditis 9.7 TG CALCA
43 thyroiditis 9.7 TG CALCA
44 carotid body cancer 9.7 TG CALCA
45 epithelial malignant thymoma 9.7 TG CALCA
46 dendritic cell thymoma 9.7 TG CALCA
47 ectopic thymus 9.7 TG CALCA
48 thyroid angiosarcoma 9.7 TG CALCA
49 thyroid lymphoma 9.7 TG CALCA
50 papillary thyroid microcarcinoma 9.7 TG CALCA

Graphical network of the top 20 diseases related to Isthmus Cancer:



Diseases related to Isthmus Cancer

Symptoms & Phenotypes for Isthmus Cancer

GenomeRNAi Phenotypes related to Isthmus Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.23 MAPK8IP1 PTPRN
2 Decreased viability GR00221-A-4 9.23 MAPK8IP1
3 Decreased viability GR00249-S 9.23 PTPRN
4 Decreased viability GR00301-A 9.23 MAPK8IP1
5 Decreased viability GR00342-S-3 9.23 MAPK8IP1
6 Decreased viability GR00386-A-1 9.23 MAPK8IP1
7 Decreased viability GR00402-S-2 9.23 MAPK8IP1

Drugs & Therapeutics for Isthmus Cancer

Search Clinical Trials , NIH Clinical Center for Isthmus Cancer

Genetic Tests for Isthmus Cancer

Anatomical Context for Isthmus Cancer

Publications for Isthmus Cancer

Variations for Isthmus Cancer

Expression for Isthmus Cancer

Search GEO for disease gene expression data for Isthmus Cancer.

Pathways for Isthmus Cancer

Pathways related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 NCAM1 LGALS3

GO Terms for Isthmus Cancer

Biological processes related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monocyte chemotaxis GO:0002548 9.16 LGALS3 CALCA
2 positive regulation of endocytosis GO:0045807 8.96 MAPK8IP2 MAPK8IP1
3 regulation of JNK cascade GO:0046328 8.62 MAPK8IP2 MAPK8IP1

Molecular functions related to Isthmus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinesin binding GO:0019894 8.96 MAPK8IP2 MAPK8IP1
2 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP2 MAPK8IP1

Sources for Isthmus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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