MCID: JCK003
MIFTS: 17

Jackhammer Esophagus

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Jackhammer Esophagus

MalaCards integrated aliases for Jackhammer Esophagus:

Name: Jackhammer Esophagus 52
Hypercontractile Esophagus 52

Classifications:



Summaries for Jackhammer Esophagus

NIH Rare Diseases : 52 Jackhammer esophagu s is a motility disorder of the esophagus, the tube that connects the mouth with the stomach, classified under esophageal spasms. Esophageal spasms are divided in 2 main types, diffuse esophageal spasm and hypertensive peristalsis or nutcracker esophagus. Jackhammer esophagus is the most serious manifestation of the hypertensive type and it is also known as hypercontractile peristalsis. Contractions (spasms) are very intensive (very high amplitude), involve most of the esophagus, and last for a long time. There is a jackhammer-type appearance on the high-resolution manometry , an exam which measures the muscle contractions that occur in the esophagus when swallowing. Symptoms may include feeding difficulty (dysphagia ) and chest pain that might be confused with a heart attack. The cause is unknown but it may occur with, or as a consequence of, other conditions, especially gastroesophageal reflux disease (GERD) . Treatment depends on the frequency and severity of the esophageal spasms. It may include medication, Botox injections, and surgical procedures. Very hot or cold liquids, loud noises, and stress may worsen dysphagia. Jackhammer esophagus can progress to achalasia , a rare and serious condition that makes it very difficult for food and liquid to pass into the stomach.

MalaCards based summary : Jackhammer Esophagus, also known as hypercontractile esophagus, is related to dysphagia and gastroesophageal reflux. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes.

Related Diseases for Jackhammer Esophagus

Diseases related to Jackhammer Esophagus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 dysphagia 10.8
2 gastroesophageal reflux 10.6
3 achalasia 10.6
4 esophagitis 10.5
5 esophagitis, eosinophilic, 1 10.5
6 hernia, hiatus 10.4
7 dyskinesia of esophagus 10.4
8 myositis 10.3
9 pulmonary disease, chronic obstructive 10.2
10 barrett esophagus 10.2
11 aspiration pneumonia 10.2
12 atrial fibrillation 10.2
13 gastroparesis 10.2
14 peptic esophagitis 10.2
15 pneumothorax 10.2
16 lung disease 10.2
17 bronchiectasis 10.2
18 hypereosinophilic syndrome 10.2
19 hypertonia 10.2

Graphical network of the top 20 diseases related to Jackhammer Esophagus:



Diseases related to Jackhammer Esophagus

Symptoms & Phenotypes for Jackhammer Esophagus

Drugs & Therapeutics for Jackhammer Esophagus

Drugs for Jackhammer Esophagus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 2
3 Cholinergic Agents Phase 2
4 Neurotransmitter Agents Phase 2
5 Botulinum Toxins Phase 2
6 Botulinum Toxins, Type A Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Injection of Botulinum Toxin in Patients With Hypercontractile Esophageal Motility Disorders: a Prospective, Randomized, Double-blind, Controlled Study Completed NCT01955174 Phase 2 Esophageal endoscopic injection of botulinum toxin
2 Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease Completed NCT03347903
3 Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in the Treatment of Medical Refractory Spastic Esophageal Disorders Withdrawn NCT02663206

Search NIH Clinical Center for Jackhammer Esophagus

Genetic Tests for Jackhammer Esophagus

Anatomical Context for Jackhammer Esophagus

MalaCards organs/tissues related to Jackhammer Esophagus:

40
Heart, Lung, Testes, Spinal Cord

Publications for Jackhammer Esophagus

Articles related to Jackhammer Esophagus:

(show top 50) (show all 129)
# Title Authors PMID Year
1
Opioid-induced esophageal dysfunction. 61
32427604 2020
2
Jackhammer esophagus: Clinical presentation, manometric diagnosis, and therapeutic results-Results from a multicenter French cohort. 61
32510747 2020
3
Hypercontractile esophagus resolved after radiofrequency catheter ablation for atrial fibrillation: About a case. 61
32483908 2020
4
Endoscopic management of gastrointestinal motility disorders - part 1: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. 61
32375192 2020
5
Jackhammer esophagus: A meta-analysis of patient demographics, disease presentation, high-resolution manometry data, and treatment outcomes. 61
32406556 2020
6
Differences in clinical characteristics between conservative-treatment-response group and refractory (surgical-treatment) group in patients with jackhammer esophagus. 61
32458101 2020
7
Should Pre-Transplant Esophageal Dysmotility Preclude Candidacy for Lung Transplantation? 61
32464848 2020
8
Jackhammer Esophagus After Lung Transplantation: Results of a Retrospective Multicenter Study. 61
31393281 2020
9
Gastroesophageal Reflux Disease Is Not Associated With Jackhammer Esophagus: A Case-control Study. 61
32235029 2020
10
Markedly Effective Steroid Treatment of Three Patients with Allergy-related Jackhammer Esophagus. 61
31708550 2020
11
Changes in high-resolution manometric diagnosis over time: implications for clinical decision-making. 61
31909786 2020
12
Clinical efficacy of per-oral endoscopic myotomy (POEM) for spastic esophageal disorders: a systematic review and meta-analysis. 61
31073769 2020
13
Per-oral endoscopic myotomy for esophageal diverticula with or without esophageal motility disorders. 61
31080116 2020
14
Peroral endoscopic myotomy for esophageal motility disorders. 61
31606768 2020
15
Progression of Jackhammer Esophagus to Type III Achalasia and Improvement After Extended Myotomy. 61
31917918 2020
16
Efficacy of per-oral endoscopic myotomy for the treatment of non-achalasia esophageal motor disorders. 61
31932930 2020
17
Clinical Symptom Presentation of Hypercontractile Peristalsis in the Era of High-Resolution Manometry: A Single-Center Experience. 61
31995802 2020
18
Jackhammer esophagus: Prevalence and demographic, clinical, and manometric characteristics. 61
31917034 2020
19
Chaotic peak propagation in patients with Jackhammer esophagus. 61
31532046 2020
20
Minor esophageal functional disorders: are they relevant? 61
31953604 2020
21
Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation. 61
31076744 2019
22
Modern Esophageal Function Testing and Gastroesophageal Reflux Disease in Morbidly Obese Patients. 61
31201693 2019
23
Difficult peroral endoscopic myotomy: definition and management strategies. 61
31566998 2019
24
Jackhammer esophagus with and without esophagogastric junction outflow obstruction demonstrates altered neural control resembling type 3 achalasia. 61
31310444 2019
25
Opioid-Induced Esophageal Dysfunction: Differential Effects of Type and Dose. 61
31403963 2019
26
Clinical outcomes and safety of high-resolution manometry guided superficial partial circular muscle myotomy in per-oral endoscopic myotomy for Jackhammer esophagus: Two cases report. 61
31531326 2019
27
[Emerging Issues in Esophageal Motility Diseases]. 61
31234622 2019
28
[Research advances of hypercontractile esophagus]. 61
31060152 2019
29
Botulinum toxin for the treatment of hypercontractile esophagus: Results of a double-blind randomized sham-controlled study. 61
30974039 2019
30
Reversible Jackhammer esophagus in a patient with a gastric band. 61
30843357 2019
31
Jackhammer Esophagus: Symptom Presentation, Associated Distal Contractile Integral, and Assessment of Bolus Transit. 61
29521727 2019
32
Provocative testing in patients with jackhammer esophagus: evidence for altered neural control. 61
30543463 2019
33
Clinical features and long-term outcomes of lower esophageal sphincter-dependent and lower esophageal sphincter-independent jackhammer esophagus. 61
30443964 2019
34
Jackhammer Esophagus: From Manometric Diagnosis to Clinical Presentation. 61
30941328 2019
35
Peroral endoscopic myotomy (POEM) is effective in treatment of noncardiac chest pain caused by hypercontractile esophageal motility disorders: results of the POEM-HYPE-Study. 61
30296811 2018
36
A case of Jackhammer esophagus caused by eosinophilic esophagitis in which per-oral endoscopic myotomy resulted in symptom improvement. 61
29790076 2018
37
Eosinophilic Esophageal Myositis (EoEM) Causes Jackhammer Esophagus, Rarely Posing a Problem in the Differential Diagnosis of Eosinophilic Esophagitis. 61
29895983 2018
38
Gender, medication use and other factors associated with esophageal motility disorders in non-obstructive dysphagia. 61
30151201 2018
39
Peroral endoscopic myotomy is effective and safe in non-achalasia esophageal motility disorders: an international multicenter study. 61
30105290 2018
40
The Relevance of Spastic Esophageal Disorders as a Diagnostic Category. 61
30079434 2018
41
Phenotypes of Jackhammer esophagus in patients with typical symptoms of gastroesophageal reflux disease responsive to proton pump inhibitors. 61
29967357 2018
42
Peroral endoscopic myotomy in pediatric jackhammer esophagus. 61
29667413 2018
43
Factors predictive of gastroesophageal reflux disease and esophageal motility disorders in patients with non-cardiac chest pain. 61
29848163 2018
44
Eosinophilia in the muscle layer of the esophagus and the urinary bladder in a Multiple System Atrophy patient with dysphagia and dysuria. 61
29633461 2018
45
Esophageal motor disorders are frequent during pre and post lung transplantation. Can they influence lung rejection? 61
29421915 2018
46
High resolution manometry and new classification of esophageal motility disorders. 61
30701897 2018
47
[Dysphagia from a gastroenterologist's perspective]. 61
29684933 2018
48
Jackhammer esophagus: Assessing the balance between prepeak and postpeak contractile integral. 61
29193439 2018
49
Dysphagia severity is related to the amplitude of distal contractile integral in patients with Jackhammer esophagus. 61
29266608 2018
50
Jackhammer Esophagus Accompanied by Esophageal Intramural Pseudodiverticulosis. 61
29225275 2018

Variations for Jackhammer Esophagus

Expression for Jackhammer Esophagus

Search GEO for disease gene expression data for Jackhammer Esophagus.

Pathways for Jackhammer Esophagus

GO Terms for Jackhammer Esophagus

Sources for Jackhammer Esophagus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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