MCID: JCK003
MIFTS: 18

Jackhammer Esophagus

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Jackhammer Esophagus

MalaCards integrated aliases for Jackhammer Esophagus:

Name: Jackhammer Esophagus 52
Hypercontractile Esophagus 52

Classifications:



Summaries for Jackhammer Esophagus

NIH Rare Diseases : 52 Jackhammer esophagu s is a motility disorder of the esophagus, the tube that connects the mouth with the stomach, classified under esophageal spasms. Esophageal spasms are divided in 2 main types, diffuse esophageal spasm and hypertensive peristalsis or nutcracker esophagus. Jackhammer esophagus is the most serious manifestation of the hypertensive type and it is also known as hypercontractile peristalsis. Contractions (spasms) are very intensive (very high amplitude), involve most of the esophagus, and last for a long time. There is a jackhammer-type appearance on the high-resolution manometry , an exam which measures the muscle contractions that occur in the esophagus when swallowing. Symptoms may include feeding difficulty (dysphagia ) and chest pain that might be confused with a heart attack. The cause is unknown but it may occur with, or as a consequence of, other conditions, especially gastroesophageal reflux disease (GERD) . Treatment depends on the frequency and severity of the esophageal spasms. It may include medication, Botox injections, and surgical procedures. Very hot or cold liquids, loud noises, and stress may worsen dysphagia. Jackhammer esophagus can progress to achalasia , a rare and serious condition that makes it very difficult for food and liquid to pass into the stomach.

MalaCards based summary : Jackhammer Esophagus, also known as hypercontractile esophagus, is related to dysphagia and achalasia. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes.

Related Diseases for Jackhammer Esophagus

Diseases related to Jackhammer Esophagus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 dysphagia 10.8
2 achalasia 10.6
3 esophagitis 10.5
4 gastroesophageal reflux 10.5
5 esophagitis, eosinophilic, 1 10.5
6 hernia, hiatus 10.4
7 dyskinesia of esophagus 10.4
8 myositis 10.3
9 pulmonary disease, chronic obstructive 10.2
10 barrett esophagus 10.2
11 aspiration pneumonia 10.2
12 atrial fibrillation 10.2
13 gastroparesis 10.2
14 peptic esophagitis 10.2
15 pneumothorax 10.2
16 lung disease 10.2
17 bronchiectasis 10.2
18 hypereosinophilic syndrome 10.2
19 hypertonia 10.2

Graphical network of the top 20 diseases related to Jackhammer Esophagus:



Diseases related to Jackhammer Esophagus

Symptoms & Phenotypes for Jackhammer Esophagus

Drugs & Therapeutics for Jackhammer Esophagus

Drugs for Jackhammer Esophagus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
2 Neurotransmitter Agents Phase 2
3 Acetylcholine Release Inhibitors Phase 2
4 Botulinum Toxins Phase 2
5 abobotulinumtoxinA Phase 2
6 Cholinergic Agents Phase 2
7 Botulinum Toxins, Type A Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Injection of Botulinum Toxin in Patients With Hypercontractile Esophageal Motility Disorders: a Prospective, Randomized, Double-blind, Controlled Study Completed NCT01955174 Phase 2 Esophageal endoscopic injection of botulinum toxin
2 Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease Completed NCT03347903
3 Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in the Treatment of Medical Refractory Spastic Esophageal Disorders Withdrawn NCT02663206

Search NIH Clinical Center for Jackhammer Esophagus

Genetic Tests for Jackhammer Esophagus

Anatomical Context for Jackhammer Esophagus

MalaCards organs/tissues related to Jackhammer Esophagus:

40
Heart, Lung, Testes, Spinal Cord

Publications for Jackhammer Esophagus

Articles related to Jackhammer Esophagus:

(show top 50) (show all 121)
# Title Authors PMID Year
1
Per-oral endoscopic myotomy for esophageal diverticula with or without esophageal motility disorders. 61
31080116 2020
2
Clinical efficacy of per-oral endoscopic myotomy (POEM) for spastic esophageal disorders: a systematic review and meta-analysis. 61
31073769 2020
3
Jackhammer esophagus: Prevalence and demographic, clinical, and manometric characteristics. 61
31917034 2020
4
Chaotic peak propagation in patients with Jackhammer esophagus. 61
31532046 2020
5
Minor esophageal functional disorders: are they relevant? 61
31953604 2020
6
Changes in high-resolution manometric diagnosis over time: implications for clinical decision-making. 61
31909786 2020
7
Clinical Symptom Presentation of Hypercontractile Peristalsis in the Era of High-Resolution Manometry: A Single-Center Experience. 61
31995802 2020
8
Peroral endoscopic myotomy for esophageal motility disorders. 61
31606768 2020
9
Efficacy of per-oral endoscopic myotomy for the treatment of non-achalasia esophageal motor disorders. 61
31932930 2020
10
Progression of Jackhammer Esophagus to Type III Achalasia and Improvement After Extended Myotomy. 61
31917918 2020
11
Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation. 61
31076744 2019
12
Modern Esophageal Function Testing and Gastroesophageal Reflux Disease in Morbidly Obese Patients. 61
31201693 2019
13
Markedly Effective Steroid Treatment of Three Patients with Allergy-related Jackhammer Esophagus. 61
31708550 2019
14
Difficult peroral endoscopic myotomy: definition and management strategies. 61
31566998 2019
15
Jackhammer esophagus with and without esophagogastric junction outflow obstruction demonstrates altered neural control resembling type 3 achalasia. 61
31310444 2019
16
Opioid-Induced Esophageal Dysfunction: Differential Effects of Type and Dose. 61
31403963 2019
17
Clinical outcomes and safety of high-resolution manometry guided superficial partial circular muscle myotomy in per-oral endoscopic myotomy for Jackhammer esophagus: Two cases report. 61
31531326 2019
18
Jackhammer Esophagus After Lung Transplantation: Results of a Retrospective Multicenter Study. 61
31393281 2019
19
[Emerging Issues in Esophageal Motility Diseases]. 61
31234622 2019
20
[Research advances of hypercontractile esophagus]. 61
31060152 2019
21
Botulinum toxin for the treatment of hypercontractile esophagus: Results of a double-blind randomized sham-controlled study. 61
30974039 2019
22
Reversible Jackhammer esophagus in a patient with a gastric band. 61
30843357 2019
23
Jackhammer Esophagus: Symptom Presentation, Associated Distal Contractile Integral, and Assessment of Bolus Transit. 61
29521727 2019
24
Provocative testing in patients with jackhammer esophagus: evidence for altered neural control. 61
30543463 2019
25
Clinical features and long-term outcomes of lower esophageal sphincter-dependent and lower esophageal sphincter-independent jackhammer esophagus. 61
30443964 2019
26
Jackhammer Esophagus: From Manometric Diagnosis to Clinical Presentation. 61
30941328 2019
27
Peroral endoscopic myotomy (POEM) is effective in treatment of noncardiac chest pain caused by hypercontractile esophageal motility disorders: results of the POEM-HYPE-Study. 61
30296811 2018
28
A case of Jackhammer esophagus caused by eosinophilic esophagitis in which per-oral endoscopic myotomy resulted in symptom improvement. 61
29790076 2018
29
Gender, medication use and other factors associated with esophageal motility disorders in non-obstructive dysphagia. 61
30151201 2018
30
Peroral endoscopic myotomy is effective and safe in non-achalasia esophageal motility disorders: an international multicenter study. 61
30105290 2018
31
The Relevance of Spastic Esophageal Disorders as a Diagnostic Category. 61
30079434 2018
32
Eosinophilic Esophageal Myositis (EoEM) Causes Jackhammer Esophagus, Rarely Posing a Problem in the Differential Diagnosis of Eosinophilic Esophagitis. 61
29895983 2018
33
Phenotypes of Jackhammer esophagus in patients with typical symptoms of gastroesophageal reflux disease responsive to proton pump inhibitors. 61
29967357 2018
34
Peroral endoscopic myotomy in pediatric jackhammer esophagus. 61
29667413 2018
35
Factors predictive of gastroesophageal reflux disease and esophageal motility disorders in patients with non-cardiac chest pain. 61
29848163 2018
36
Eosinophilia in the muscle layer of the esophagus and the urinary bladder in a Multiple System Atrophy patient with dysphagia and dysuria. 61
29633461 2018
37
Esophageal motor disorders are frequent during pre and post lung transplantation. Can they influence lung rejection? 61
29421915 2018
38
High resolution manometry and new classification of esophageal motility disorders. 61
30701897 2018
39
Jackhammer esophagus: Assessing the balance between prepeak and postpeak contractile integral. 61
29193439 2018
40
Dysphagia severity is related to the amplitude of distal contractile integral in patients with Jackhammer esophagus. 61
29266608 2018
41
[Dysphagia from a gastroenterologist's perspective]. 61
29684933 2018
42
Jackhammer Esophagus Accompanied by Esophageal Intramural Pseudodiverticulosis. 61
29225275 2018
43
Non-Cardiac Chest Pain. 61
29888236 2018
44
A case of ventilatory impairment during per-oral endoscopic myotomy under general anesthesia. 61
32026954 2018
45
Factors Determining the Inter-observer Variability and Diagnostic Accuracy of High-resolution Manometry for Esophageal Motility Disorders. 61
29291608 2018
46
Esophageal Motility after Extensive Circumferential Endoscopic Submucosal Dissection for Superficial Esophageal Cancer. 61
29870972 2018
47
Eosinophilic Esophageal Myositis a Plausible Cause of Histological Changes of Primary Jackhammer Esophagus: A Case Report. 61
29311727 2018
48
Pathogenesis of Potassium-Competitive Acid Blocker-Resistant Non-Erosive Reflux Disease. 61
29870976 2018
49
Current Status of Peroral Endoscopic Myotomy. 61
29397656 2018
50
Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function. 61
29698944 2018

Variations for Jackhammer Esophagus

Expression for Jackhammer Esophagus

Search GEO for disease gene expression data for Jackhammer Esophagus.

Pathways for Jackhammer Esophagus

GO Terms for Jackhammer Esophagus

Sources for Jackhammer Esophagus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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