JE
MCID: JPN002
MIFTS: 60

Japanese Encephalitis (JE)

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Japanese Encephalitis

MalaCards integrated aliases for Japanese Encephalitis:

Name: Japanese Encephalitis 12 76 53 59 3 3 15 73
Je 53 3
Japanese B Encephalitis 12
Encephalitis, Japanese 44
Encephalitis Japanese 55

Characteristics:

Orphanet epidemiological data:

59
japanese encephalitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:10844
ICD10 33 A83.0
ICD9CM 35 062.0
MeSH 44 D004672
NCIt 50 C34577
SNOMED-CT 68 52947006
Orphanet 59 ORPHA79139
MESH via Orphanet 45 D004672
UMLS via Orphanet 74 C0014057
ICD10 via Orphanet 34 A83.0
UMLS 73 C0014057

Summaries for Japanese Encephalitis

CDC : 3 Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia and the western Pacific. For most travelers to Asia, the risk for JE is very low but varies based on destination, duration of travel, season, and activities. JE virus is maintained in a cycle involving mosquitoes and vertebrate hosts, mainly pigs and wading birds. Humans can be infected when bitten by an infected mosquito. Most human infections are asymptomatic or result in only mild symptoms. However, a small percentage of infected persons develop inflammation of the brain (encephalitis), with symptoms including sudden onset of headache, high fever, disorientation, coma, tremors and convulsions. About 1 in 4 cases are fatal. There is no specific treatment for JE. Patient management focuses on supportive care and management of complications. Steps to prevent JE include using personal protective measures to prevent mosquito bites and vaccination.

MalaCards based summary : Japanese Encephalitis, also known as je, is related to encephalitis and west nile virus, and has symptoms including coma, headache and disorientation. An important gene associated with Japanese Encephalitis is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ethanol and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A viral infectious disease that results in infection located in brain, has material basis in Japanese encephalitis virus, which is transmitted by Culex tritaeniorhynchus mosquito bite. The infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, and has symptom spastic paralysis.

Wikipedia : 76 Japanese encephalitis (JE) is an infection of the brain caused by the Japanese encephalitis virus (JEV).... more...

Related Diseases for Japanese Encephalitis

Diseases related to Japanese Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 encephalitis 30.7 TLR3 DDX58 CXCL10 CLEC4M CLEC4G CD209
2 west nile virus 30.3 CD209 CLEC4M DDX58 TLR3
3 hemorrhagic fever 29.9 TNF CD209
4 chikungunya 29.8 TNF DDX58 CCL5
5 tick-borne encephalitis 29.7 TLR3 CXCL10 CD209
6 viral encephalitis 29.7 TNF CXCL10 CCL5
7 venezuelan equine encephalitis 29.7 STAT1 IFNB1
8 noonan syndrome 3 29.7 TLR3 IFNB1 DDX58
9 herpes simplex 29.6 TLR3 IFNB1 DDX58 CD209
10 viral infectious disease 29.6 TNF TLR3 STAT1 IFNB1 DDX58 CXCL10
11 measles 29.4 CD209 DDX58 IFNB1 STAT1 TLR3
12 avian influenza 29.4 TNF DDX58 CXCL10
13 rabies 29.4 CCL5 CXCL10 STAT1 TLR3
14 dengue hemorrhagic fever 29.3 CD209 STAT1 TLR3 TNF
15 influenza 28.9 CCL5 CXCL10 DDX58 IFNB1 TLR3
16 hepatitis c 28.6 TNF TLR3 STAT1 IFNB1 DDX58 CXCL10
17 st. louis encephalitis 11.5
18 dengue virus 10.3
19 zika fever 10.2 STAT1 IFNB1
20 la crosse encephalitis 10.2 IFNB1 DDX58
21 yellow fever 10.1
22 listeria meningitis 10.1 TNF IFNB1
23 ocular hyperemia 10.1 SOD1 IFNB1
24 malaria 10.1
25 respiratory syncytial virus infectious disease 10.1 IFNB1 CCL5
26 autoimmune peripheral neuropathy 10.1 IFNB1 CXCL10
27 murray valley encephalitis 10.1
28 compartment syndrome 10.1 TNF HELLS
29 anthracosis 10.0 TNF SOD1
30 microphthalmia with limb anomalies 10.0 STAT1 IFNB1
31 erysipelas 10.0 TNF SOD1
32 marburg hemorrhagic fever 10.0 CD209 IFNB1 TNF
33 acute cervicitis 10.0 CXCL10 CCL5
34 crimean-congo hemorrhagic fever 10.0 TNF CXCL10
35 scorpion envenomation 10.0 TNF CCL5
36 neuroblastoma 10.0
37 noonan syndrome 5 10.0
38 stromal keratitis 10.0 TNF CXCL10
39 newcastle disease 10.0 TNF IFNB1 DDX58
40 eales disease 10.0 TNF SOD1
41 progressive multifocal leukoencephalopathy 10.0 TNF STAT1
42 spinal cord disease 10.0 TNF IFNB1
43 glaucomatocyclitic crisis 10.0 TNF CXCL10
44 stachybotrys chartarum 10.0 TNF CCL5
45 retinal vasculitis 10.0 TLR3 IFNB1
46 viral meningitis 10.0 CXCL10 CCL5
47 orofacial granulomatosis 10.0 TNF CCL5
48 autoimmune disease of eyes, ear, nose and throat 10.0 TNF CCL5
49 mycobacterium tuberculosis 1 10.0 TNF CXCL10 CD209
50 acute myocarditis 10.0 TLR3 STAT1

Graphical network of the top 20 diseases related to Japanese Encephalitis:



Diseases related to Japanese Encephalitis

Symptoms & Phenotypes for Japanese Encephalitis

Symptoms:

12
  • coma
  • headache
  • disorientation
  • tremors
  • stupor
  • spastic paralysis
  • neck stiffness
  • convulsions
  • high fever

MGI Mouse Phenotypes related to Japanese Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CCL5 CLEC4G CLEC4M CXCL10 DDX58 HELLS
2 homeostasis/metabolism MP:0005376 9.85 CLEC4G CLEC4M CXCL10 DDX58 HELLS IFNB1
3 immune system MP:0005387 9.7 CCL5 CLEC4G CLEC4M CXCL10 DDX58 HELLS
4 neoplasm MP:0002006 9.1 DDX58 IFNB1 SOD1 STAT1 TLR3 TNF

Drugs & Therapeutics for Japanese Encephalitis

Drugs for Japanese Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
4 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
6 Antibodies, Blocking Phase 4,Phase 3,Phase 2
7
Aluminum hydroxide Approved, Investigational Phase 3,Phase 1 21645-51-2
8
Lactitol Investigational Phase 3 585-86-4 3871
9 DEET Phase 3
10 Insect Repellents Phase 3
11 Protective Agents Phase 3
12 Pharmaceutical Solutions Phase 3,Phase 2
13 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
14
Ribavirin Approved Phase 2 36791-04-5 37542
15
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
16 Antimetabolites Phase 2
17 Anti-Infective Agents Phase 2
18 Antiviral Agents Phase 2
19 Immunoglobulins, Intravenous Phase 2
20 gamma-Globulins Phase 2
21 Rho(D) Immune Globulin Phase 2
22
Aluminum sulfate Approved Phase 1 10043-01-3
23
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
24
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
25
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030

Interventional clinical trials:

(show top 50) (show all 85)
# Name Status NCT ID Phase Drugs
1 Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Unknown status NCT01954810 Phase 4
2 A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2 Completed NCT01656200 Phase 4
3 Long-term Immunogenicity and Safety of Fourth Administration of Boryung Cell-Culture Japanese Encephalitis Vaccineinj Completed NCT02532569 Phase 4
4 Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX Completed NCT02526550 Phase 4
5 Immunogenicity of Co-administration of Measles and Japanese Encephalitis Vaccines Completed NCT02643433 Phase 4
6 Lot-to-lot Consistency Trial of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine Completed NCT01567865 Phase 4
7 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
8 Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine Completed NCT01398540 Phase 4
9 This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population Completed NCT01158599 Phase 4
10 6-year Antibody Check After Third Vaccination Against Japanese Encephalitis Completed NCT02039440 Phase 4
11 Post-licensure Safety Study of IMOJEV® in Thailand Completed NCT01981967 Phase 4
12 Long-term Immunogenicity After Receipt of JE Vaccine and Antibody Response and Safety to a Booster Dose Completed NCT02514746 Phase 4
13 Immunogenicity of SA 14-14-2 JE Vaccine Completed NCT01635816 Phase 4
14 Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine Completed NCT01815073 Phase 4
15 Clinical Study on Combined Immune Effect of EV71 Inactivated Vaccine Recruiting NCT03519568 Phase 4
16 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
17 Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR Unknown status NCT00938379 Phase 3 20% deet insect repellent;placebo control
18 Study of a Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV™) Compared to CD.JEVAX™ in Toddlers Completed NCT01396512 Phase 3
19 A Study of Japanese Encephalitis Chimeric Virus Vaccine Compared With SA14-14-2 Vaccine in Infants and Toddlers Completed NCT01092507 Phase 3
20 Study of a Single Primary Dose Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV®) in Healthy Subjects Completed NCT02492165 Phase 3
21 Study of ChimeriVax™-Japanese Encephalitis Vaccine in Toddlers in Thailand and the Philippines Completed NCT00735644 Phase 3
22 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
23 Ixiaro as Booster After Mouse-brain Derived Vaccines for Japanese Encephalitis Completed NCT01386827 Phase 3
24 Rapid Immunization Study of the Japanese Encephalitis Vaccine IC51 Completed NCT00595790 Phase 3
25 Long Term Persistence and Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51 Completed NCT00595270 Phase 3
26 Immunogenicity Study of the Japanese Encephalitis Vaccine IC51 Completed NCT00604708 Phase 3
27 Safety and Immunogenicity of 2 Different Vaccination Schedules of Rabies and Japanese Encephalitis Vaccines in Healthy Adult Subjects Completed NCT01662440 Phase 3
28 Live Attenuated Japanese Encephalitis (JE) Vaccine Coadministered With Measles Vaccine in Infants 9 Months of Age Completed NCT00463684 Phase 3
29 A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVax™-JE and JE-VAX Completed NCT00314145 Phase 3
30 Boosterability of Live Attenuated Japanese Encephalitis (JE) Vaccine in Children Who Have Previously Received Inactivated JE Vaccine Completed NCT00463476 Phase 3
31 Safety and Tolerability of the Japanese Encephalitis Vaccine IC51 Completed NCT00605085 Phase 3
32 Study of a Booster Dose of IMOJEV® One Year After Primary Immunization in Healthy Children in South Korea Completed NCT01900444 Phase 3
33 A Clinical Trial for Inactivated Japanese Encephalitis Vaccine in Healthy Chinese Infants Completed NCT02367664 Phase 3
34 Comparison of Three Commercial Batches of the Japanese Encephalitis Vaccine IC51 Completed NCT00595465 Phase 3
35 Comparison of Three Batches of the Japanese Encephalitis Vaccine IC51 Completed NCT00594958 Phase 3
36 Long-term Follow-up of Immunogenicity of a Single Dose of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Toddlers Completed NCT01001988 Phase 3
37 Study of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Previously Immunized With JE-CV Completed NCT01190228 Phase 3
38 Determining Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine Completed NCT00249769 Phase 3
39 Concomitant Vaccination With the Japanese Encephalitis Vaccine IC51 and HARVIX® 1440 Completed NCT00596271 Phase 3
40 Safety and Immunogenicity of the Japanese Encephalitis Vaccine IC51 (IXIARO®) in a Pediatric Population Completed NCT01041573 Phase 3
41 Open-label, Randomized Study in a Pediatric Population in a JEV (Japanese Encephalitis Virus)-Endemic Country Completed NCT01296360 Phase 3
42 Safety Study of ChimeriVax™-JE Vaccine to Prevent Japanese Encephalitis. Completed NCT00314132 Phase 3
43 Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51 Completed NCT00595309 Phase 3
44 Immunogenicity of a Commercial Batch of JEV IC51 up to 24 Months Post Filling Completed NCT00776230 Phase 3
45 Immunogenicity and Safety of Inactivated Vero Cell Derived Japanese Encephalitis Vaccine in Thai Children Completed NCT01408537 Phase 3
46 Determining Long-Term Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine Completed NCT00412516 Phase 3
47 Evaluate Safety and Immunogenicity of a Vero Cell-Derived JE Vaccine in 9-24 Months of Age Children in Vietnam Completed NCT03282370 Phase 3
48 Immunogenicity and Safety of the Japanese Encephalitis Vaccine IC51 (IXIARO®, JESPECT®) in a Pediatric Population in Non-endemic Countries Completed NCT01047839 Phase 3
49 Clinical Trial to Assess the Immunogenicity and Safety of the Vero Cell-derived JE Vaccine in Korea Completed NCT01150942 Phase 3
50 Long Term Immunity and Safety Following Vaccination With the JEV IC51 (IXIARO®, JESPECT®) in Pediatric Population In Non Endemic Countries. Uncontrolled, Ph3 FU-Study Completed NCT01246479 Phase 3

Search NIH Clinical Center for Japanese Encephalitis

Cochrane evidence based reviews: encephalitis, japanese

Genetic Tests for Japanese Encephalitis

Anatomical Context for Japanese Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Japanese Encephalitis:

19
Brain

MalaCards organs/tissues related to Japanese Encephalitis:

41
Brain, Monocytes, T Cells, Testes, Endothelial, B Cells, Bone

Publications for Japanese Encephalitis

Articles related to Japanese Encephalitis:

(show top 50) (show all 1350)
# Title Authors Year
1
Crustin-capped selenium nanowires against microbial pathogens and Japanese encephalitis mosquito vectors - Insights on their toxicity and internalization. ( 30466931 )
2019
2
Development of a Japanese encephalitis virus genotype V virus-like particle vaccine in silkworms. ( 29877787 )
2018
3
Mutation of I176R in the E coding region weakens Japanese encephalitis virus neurovirulence, but not its growth rate in BHK-21 cells. ( 29411136 )
2018
4
IP-10 Promotes Blood-Brain Barrier Damage by Inducing Tumor Necrosis Factor Alpha Production in Japanese Encephalitis. ( 29910805 )
2018
5
Overview of Japanese encephalitis disease and its prevention. Focus on IC51 vaccine (IXIARO<sup>Ar</sup>). ( 29938245 )
2018
6
Five-Year Antibody Persistence Following a Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) Booster in JE-CV-Primed Children in the Philippines. ( 29325161 )
2018
7
Protecting children against Japanese encephalitis in Bali, Indonesia. ( 29976465 )
2018
8
Modelling the skip-and-resurgence of Japanese encephalitis epidemics in Hong Kong. ( 29792875 )
2018
9
Diphenyleneiodonium enhances oxidative stress and inhibits Japanese encephalitis virus induced autophagy and ER stress pathways. ( 29792860 )
2018
10
Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway. ( 29885805 )
2018
11
TaqMan real-time RT-PCR assay for detecting Japanese encephalitis virus in swine blood samples and mosquitoes. ( 29938578 )
2018
12
Epigallocatechin-3-gallate inhibits the early stages of Japanese encephalitis virus infection. ( 29958923 )
2018
13
Association of ICAM-1 (K469E) and MCP-1-2518 Aa8^&amp;gt;a8^G polymorphism with risk of Japanese encephalitis in North Indian population. ( 29871779 )
2018
14
Detection of Japanese Encephalitis Virus in bone marrow of healthy young wild birds collected in 1997-2000 in Central Italy. ( 29974677 )
2018
15
Changes of Epidemiological Characteristics of Japanese Encephalitis Viral Infection and Birds as a Potential Viral Transmitter in Korea. ( 29441740 )
2018
16
Japanese encephalitis. ( 29807939 )
2018
17
Evolving Epidemiology of Japanese Encephalitis: Implications for Vaccination. ( 29959548 )
2018
18
Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children. ( 29227177 )
2018
19
Japanese encephalitis in a 59-year-old female: Brain image finding. ( 29884526 )
2018
20
Human Kinase/Phosphatase-Wide RNAi Screening Identified Checkpoint Kinase 2 as a Cellular Factor Facilitating Japanese Encephalitis Virus Infection. ( 29868498 )
2018
21
Effect of prior dengue infection on severity and outcome of Japanese encephalitis. ( 29411187 )
2018
22
Meta-Analyses of Japanese Encephalitis Virus Infection, Dissemination, and Transmission Rates in Vectors. ( 29363456 )
2018
23
Japanese encephalitis in Malaysia: An overview and timeline. ( 29856986 )
2018
24
Risk assessment for Japanese encephalitis vaccination. ( 29244615 )
2018
25
A Simple Mechanism Based on Amino Acid Substitutions is not a Critical Determinant of High Mortality of Japanese Encephalitis Virus Infection in Mice. ( 29401664 )
2018
26
Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies. ( 29379207 )
2018
27
Antibody Persistence up to 3 Years after Primary Immunization with Inactivated Japanese Encephalitis Vaccine IXIAROAr in Philippine Children and Effect of a Booster Dose. ( 29912844 )
2018
28
Comparison of neutralizing antibody titers against Japanese encephalitis virus genotype V strain with those against genotype I and III strains in the sera of Japanese encephalitis patients in Japan in 2016. ( 29962489 )
2018
29
Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. ( 29915260 )
2018
30
Adverse events following vaccination with an inactivated, Vero cell culture-derived Japanese encephalitis vaccine in the United States, 2012-2016. ( 29891351 )
2018
31
An infection cocktail: malaria, dengue, chikungunya and Japanese encephalitis. ( 30259796 )
2018
32
A quantitative risk assessment (QRA) of the risk of introduction of the Japanese encephalitis virus (JEV) in the United States via infected mosquitoes transported in aircraft and cargo ships. ( 30388990 )
2018
33
Structure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus. ( 30413749 )
2018
34
TIM-1 Promotes Japanese Encephalitis Virus Entry and Infection. ( 30441759 )
2018
35
Teaching NeuroImages: Japanese encephalitis. ( 30455264 )
2018
36
Artificial MicroRNA-Mediated Inhibition of Japanese Encephalitis Virus Replication in Neuronal Cells. ( 30457923 )
2018
37
Evaluation of cholinergic functions in patients with Japanese encephalitis and Herpes simplex encephalitis. ( 30468725 )
2018
38
Possible pathogenicity of Japanese encephalitis virus in newly hatched domestic ducklings. ( 30473356 )
2018
39
Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5. ( 30481615 )
2018
40
Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells. ( 30489239 )
2018
41
Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. ( 30527622 )
2018
42
Japanese Encephalitis Virus NS1' Protein Antagonizes Interferon Beta Production. ( 30542978 )
2018
43
Japanese Encephalitis Virus-induced let-7a/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation. ( 30556910 )
2018
44
Increased serum microRNA-29b expression and bad recovery in Japanese encephalitis virus infected patients; A new component to improve the disease recovery. ( 30196835 )
2018
45
Changing Geographic Distribution of Japanese Encephalitis Virus Genotypes, 1935-2017. ( 30207876 )
2018
46
Effective inhibition of different Japanese encephalitis virus genotypes by RNA interference targeting two conserved viral gene sequences in vitro and in vivo. ( 30229544 )
2018
47
Modeling the long-term persistence of neutralizing antibody in children and toddlers after vaccination with live attenuated Japanese encephalitis chimeric virus vaccine. ( 30230947 )
2018
48
A rare case of Japanese encephalitis-induced anti-N-methyl-d-aspartate receptor encephalitis. ( 30233032 )
2018
49
Dengue and Japanese encephalitis E: Concurrent infection, cross reactivity, and false positivity. ( 30233048 )
2018
50
Molecular and clinical relationship between live-attenuated Japanese encephalitis vaccination and childhood onset myasthenia gravis. ( 30246904 )
2018

Variations for Japanese Encephalitis

Expression for Japanese Encephalitis

Search GEO for disease gene expression data for Japanese Encephalitis.

Pathways for Japanese Encephalitis

Pathways related to Japanese Encephalitis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CCL5 CD209 CXCL10 DDX58 IFNB1 STAT1
2
Show member pathways
13.16 CCL5 CXCL10 DDX58 IFNB1 STAT1 TNF
3
Show member pathways
12.84 CCL5 DDX58 IFNB1 STAT1 TLR3 TNF
4
Show member pathways
12.79 CCL5 CXCL10 IFNB1 STAT1 TLR3 TNF
5
Show member pathways
12.51 CCL5 CXCL10 DDX58 IFNB1 TLR3 TNF
6
Show member pathways
12.15 CCL5 SOD1 TNF
7 12.15 CCL5 CXCL10 DDX58 STAT1 TLR3 TNF
8
Show member pathways
12.08 IFNB1 TLR3 TNF
9
Show member pathways
12.08 CD209 CLEC4M STAT1 TNF
10
Show member pathways
12.06 IFNB1 STAT1 TLR3 TNF
11
Show member pathways
12.03 CXCL10 IFNB1 STAT1 TNF
12 12.02 CXCL10 DDX58 IFNB1 STAT1 TNF
13 12 STAT1 TLR3 TNF
14
Show member pathways
11.96 CCL5 CD209 CLEC4M CXCL10 DDX58 IFNB1
15 11.91 CD209 CLEC4M IFNB1 STAT1 TNF
16
Show member pathways
11.88 STAT1 TLR3 TNF
17 11.87 IFNB1 STAT1 TNF
18 11.75 CCL5 CXCL10 IFNB1 TNF
19 11.61 CD209 IFNB1 TNF
20 11.59 CCL5 CXCL10 TNF
21 11.47 DDX58 IFNB1 STAT1 TLR3 TNF
22 11.41 CCL5 CXCL10 TNF
23 11.24 CXCL10 IFNB1 STAT1
24 11.18 CCL5 SOD1
25 11.09 IFNB1 TNF
26 11.02 CCL5 CXCL10 TNF
27 10.99 CCL5 IFNB1 TNF
28
Show member pathways
10.96 DDX58 STAT1

GO Terms for Japanese Encephalitis

Cellular components related to Japanese Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 CCL5 CXCL10 IFNB1 SOD1 TLR3 TNF
2 extracellular region GO:0005576 9.5 CCL5 CD209 CLEC4M CXCL10 IFNB1 SOD1
3 host cell GO:0043657 8.62 CD209 CLEC4M

Biological processes related to Japanese Encephalitis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.99 CD209 CLEC4M DDX58 TLR3
2 innate immune response GO:0045087 9.98 CD209 CLEC4M DDX58 TLR3
3 regulation of signaling receptor activity GO:0010469 9.96 CCL5 CXCL10 IFNB1 TNF
4 inflammatory response GO:0006954 9.94 CCL5 CXCL10 TLR3 TNF
5 viral process GO:0016032 9.92 CD209 CLEC4G CLEC4M DDX58 STAT1
6 cellular response to interferon-gamma GO:0071346 9.8 CCL5 STAT1 TLR3
7 viral entry into host cell GO:0046718 9.79 CD209 CLEC4G CLEC4M
8 cellular response to organic cyclic compound GO:0071407 9.77 CCL5 STAT1 TNF
9 defense response GO:0006952 9.76 CXCL10 IFNB1 TLR3 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.74 DDX58 TLR3 TNF
11 cytokine-mediated signaling pathway GO:0019221 9.72 CCL5 CXCL10 IFNB1 STAT1 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 CCL5 STAT1 TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.68 CCL5 TNF
14 regulation of protein kinase activity GO:0045859 9.68 CXCL10 SOD1
15 positive regulation of interferon-beta production GO:0032728 9.68 DDX58 TLR3
16 negative regulation of myoblast differentiation GO:0045662 9.67 CXCL10 TNF
17 positive regulation of defense response to virus by host GO:0002230 9.67 DDX58 STAT1
18 positive regulation of innate immune response GO:0045089 9.67 CCL5 IFNB1
19 negative regulation of viral genome replication GO:0045071 9.67 CCL5 IFNB1 TNF
20 positive regulation of chemokine production GO:0032722 9.66 TLR3 TNF
21 microglial cell activation GO:0001774 9.65 TLR3 TNF
22 positive regulation of monocyte chemotaxis GO:0090026 9.65 CCL5 CXCL10
23 positive regulation of T cell migration GO:2000406 9.65 CCL5 CXCL10
24 response to exogenous dsRNA GO:0043330 9.65 DDX58 IFNB1 TLR3
25 viral genome replication GO:0019079 9.64 CD209 CLEC4M
26 positive regulation of interferon-alpha production GO:0032727 9.63 DDX58 STAT1
27 intracellular transport of virus GO:0075733 9.62 CD209 CLEC4M
28 positive regulation of chemokine biosynthetic process GO:0045080 9.61 TLR3 TNF
29 positive regulation of cytokine production GO:0001819 9.61 SOD1 TLR3 TNF
30 modulation by virus of host morphology or physiology GO:0019048 9.6 CD209 CLEC4M
31 cell-cell recognition GO:0009988 9.58 CD209 CLEC4M
32 necroptotic signaling pathway GO:0097527 9.58 TLR3 TNF
33 leukocyte cell-cell adhesion GO:0007159 9.58 CCL5 CD209 CLEC4M
34 detection of virus GO:0009597 9.56 DDX58 TLR3
35 virion attachment to host cell GO:0019062 9.55 CD209 CLEC4M
36 positive regulation of interleukin-8 production GO:0032757 9.54 DDX58 TLR3 TNF
37 peptide antigen transport GO:0046968 9.51 CD209 CLEC4M
38 cellular response to interferon-beta GO:0035458 9.43 IFNB1 STAT1 TLR3
39 defense response to virus GO:0051607 9.35 CXCL10 DDX58 IFNB1 STAT1 TLR3
40 cellular response to exogenous dsRNA GO:0071360 9.33 DDX58 IFNB1 TLR3
41 response to virus GO:0009615 9.1 CCL5 CXCL10 DDX58 IFNB1 TLR3 TNF
42 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 CXCL10 DDX58 IFNB1 STAT1 TLR3 TNF

Molecular functions related to Japanese Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.63 CD209 CLEC4G CLEC4M
2 peptide antigen binding GO:0042605 9.43 CD209 CLEC4M
3 virus receptor activity GO:0001618 9.43 CD209 CLEC4G CLEC4M
4 identical protein binding GO:0042802 9.43 CCL5 DDX58 SOD1 STAT1 TLR3 TNF
5 tumor necrosis factor receptor binding GO:0005164 9.4 STAT1 TNF
6 mannose binding GO:0005537 9.37 CD209 CLEC4M
7 virion binding GO:0046790 9.32 CD209 CLEC4M
8 CCR5 chemokine receptor binding GO:0031730 9.16 CCL5 STAT1
9 cytokine activity GO:0005125 8.92 CCL5 CXCL10 IFNB1 TNF

Sources for Japanese Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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