Aliases & Classifications for Japanese Spotted Fever

MalaCards integrated aliases for Japanese Spotted Fever:

Name: Japanese Spotted Fever 12 15
Rickettsia Japonica Spotted Fever 12
Oriental Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050050

Summaries for Japanese Spotted Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia japonica, which is transmitted by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary : Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to spotted fever and scrub typhus, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways/superpathways are PAK Pathway and Akt Signaling. Affiliated tissues include testes, skin and liver, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 spotted fever 31.2 AFF2 CXCL10 PLEKHG4
2 scrub typhus 30.6 CD40LG CRP
3 endemic typhus 10.8 AFF2 PLEKHG4
4 brill-zinsser disease 10.8 AFF2 CD40LG
5 indian tick typhus 10.8 CD40LG PLEKHG4
6 ornithosis 10.8 AFF2 CD40LG
7 rocky mountain spotted fever 10.8 AFF2 CD40LG
8 acalculous cholecystitis 10.7 CD40LG CRP
9 mononeuritis multiplex 10.7 CD40LG CRP
10 acute maxillary sinusitis 10.6 CD40LG CRP
11 epidemic typhus 10.6 AFF2 CD40LG
12 suppurative otitis media 10.6 CD40LG CRP
13 epididymitis 10.6 CD40LG CRP
14 dressler's syndrome 10.6 CD40LG CRP
15 hypersensitivity vasculitis 10.6 CD40LG CRP
16 central nervous system vasculitis 10.6 CD40LG CRP
17 intussusception 10.6 CD40LG CRP
18 hypersensitivity reaction type iii disease 10.6 CD40LG CRP
19 pyelitis 10.6 CD40LG CRP
20 chronic meningitis 10.6 CCL11 CRP
21 eosinophilic meningitis 10.6 CCL11 CD40LG
22 streptococcal meningitis 10.6 CD40LG CRP
23 endocardium disease 10.6 CD40LG CRP
24 asymptomatic neurosyphilis 10.5 CD40LG CXCL10
25 granulomatous hepatitis 10.5 CD40LG CRP
26 syphilitic meningitis 10.5 CD40LG SERPINC1
27 fournier gangrene 10.5 CD40LG SERPINC1
28 heparin-induced thrombocytopenia 10.5 CD40LG SERPINC1
29 conjunctival disease 10.5 CCL11 CD40LG
30 dirofilariasis 10.5 CD40LG CRP
31 trench fever 10.5 CD40LG KANTR
32 cerebral arteritis 10.5 CD40LG KANTR
33 multiple cranial nerve palsy 10.5 CD40LG CRP
34 geniculate herpes zoster 10.5 CD40LG KANTR
35 facial hemiatrophy 10.5 CD40LG KANTR
36 brachial plexus neuritis 10.5 CD40LG KANTR
37 pelvic inflammatory disease 10.5 CD40LG CRP
38 flinders island spotted fever 10.5 AFF2 CD40LG PLEKHG4
39 hemorrhagic fever with renal syndrome 10.4 CD40LG CRP
40 blue toe syndrome 10.4 CRP SERPINC1
41 dental abscess 10.4 CRP KANTR
42 lymphoproliferative syndrome 2 10.4 CD40LG CXCL10
43 korean hemorrhagic fever 10.4 CD40LG SERPINC1
44 lymph node disease 10.4 CD40LG CRP
45 facial nerve disease 10.4 CD40LG KANTR
46 angina pectoris 10.4 CRP SERPINC1
47 exanthem 10.4 CD40LG CRP
48 acute pyelonephritis 10.4 CRP CXCL10
49 functional colonic disease 10.4 CD40LG KANTR
50 hemorrhagic fever 10.4 CD40LG SERPINC1

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to Japanese Spotted Fever

Symptoms & Phenotypes for Japanese Spotted Fever

Symptoms:

12
  • fever
  • eschars
  • regional adenopathy
  • rash on extremities

GenomeRNAi Phenotypes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00231-A 9.02 CCL4 CXCL10
2 Decreased viability GR00342-S-3 9.02 CCL4
3 Decreased viability GR00402-S-2 9.02 CCL4 CXCL10

Drugs & Therapeutics for Japanese Spotted Fever

Search Clinical Trials , NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

Anatomical Context for Japanese Spotted Fever

MalaCards organs/tissues related to Japanese Spotted Fever:

41
Testes, Skin, Liver

Publications for Japanese Spotted Fever

Articles related to Japanese Spotted Fever:

(show all 38)
# Title Authors Year
1
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
2
Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan. ( 29722440 )
2018
3
Important Clinical Features of Japanese Spotted Fever. ( 29968555 )
2018
4
Japanese spotted fever. ( 29660067 )
2018
5
Two cases of Japanese spotted fever infected in Rokko mountain near urban area of southern Hyogo Prefecture. ( 29315729 )
2018
6
Case Report: Family Cluster of Japanese Spotted Fever. ( 29363442 )
2018
7
Geographical Distribution of Japanese Spotted Fever and Tsutsugamushi Disease in Japan - Possible Effect of Environmental Temperature. ( 28250253 )
2017
8
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. ( 26130479 )
2015
9
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. ( 24671792 )
2014
10
A neonatal case of Japanese spotted fever. ( 23743544 )
2013
11
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. ( 21668575 )
2012
12
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. ( 22466839 )
2012
13
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. ( 20553108 )
2011
14
Predictive values of clinical parameters for severe Japanese spotted fever. ( 20827564 )
2011
15
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? ( 21091673 )
2010
16
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. ( 19688250 )
2009
17
A case of Japanese spotted fever complicated with acute myocarditis. ( 17314430 )
2007
18
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. ( 17642547 )
2007
19
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. ( 16922489 )
2006
20
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. ( 16936351 )
2006
21
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. ( 16785708 )
2006
22
Severe Japanese spotted fever successfully treated with fluoroquinolone. ( 17170509 )
2006
23
Japanese spotted fever, South Korea. ( 16836831 )
2006
24
Japanese spotted fever in Korea. ( 16082011 )
2005
25
Clinical study of Japanese spotted fever and its aggravating factors. ( 12673413 )
2003
26
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. ( 12373493 )
2002
27
Japanese spotted fever involving the central nervous system: two case reports and a literature review. ( 12354906 )
2002
28
Japanese spotted fever associated with multiorgan failure. ( 11810592 )
2001
29
Fulminant Japanese spotted fever associated with hypercytokinemia. ( 11376087 )
2001
30
A patient with Japanese spotted fever complicated by meningoencephalitis. ( 11605191 )
2001
31
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. ( 11135712 )
2000
32
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. ( 10871919 )
2000
33
Japanese spotted fever cases in Kochi prefecture. ( 10777859 )
2000
34
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. ( 10783585 )
2000
35
Japanese spotted fever: report of 31 cases and review of the literature. ( 9204291 )
1997
36
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. ( 8189407 )
1994
37
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. ( 1383270 )
1992
38
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. ( 1603001 )
1992

Variations for Japanese Spotted Fever

Expression for Japanese Spotted Fever

Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for Japanese Spotted Fever

GO Terms for Japanese Spotted Fever

Cellular components related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL11 CCL4 CCL4L1 CD40LG CRP CXCL10

Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 CCL11 CCL4 CD40LG CXCL10
2 regulation of signaling receptor activity GO:0010469 9.72 CCL11 CCL4 CCL4L1 CD40LG CXCL10
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 CCL11 CCL4 CCL4L1
4 chemotaxis GO:0006935 9.69 CCL11 CCL4 CXCL10
5 cellular response to tumor necrosis factor GO:0071356 9.67 CCL11 CCL4 CCL4L1
6 response to virus GO:0009615 9.65 CCL11 CCL4 CXCL10
7 cellular response to interferon-gamma GO:0071346 9.63 CCL11 CCL4 CCL4L1
8 cellular response to interleukin-1 GO:0071347 9.61 CCL11 CCL4 CCL4L1
9 neutrophil chemotaxis GO:0030593 9.58 CCL11 CCL4 CCL4L1
10 monocyte chemotaxis GO:0002548 9.54 CCL11 CCL4 CCL4L1
11 lymphocyte chemotaxis GO:0048247 9.43 CCL11 CCL4 CCL4L1
12 eosinophil chemotaxis GO:0048245 9.33 CCL11 CCL4 CCL4L1
13 chemokine-mediated signaling pathway GO:0070098 9.26 CCL11 CCL4 CCL4L1 CXCL10
14 inflammatory response GO:0006954 9.1 CCL11 CCL4 CCL4L1 CD40LG CRP CXCL10

Molecular functions related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CCL11 CCL4 CD40LG CXCL10
2 CCR chemokine receptor binding GO:0048020 9.13 CCL11 CCL4 CCL4L1
3 chemokine activity GO:0008009 8.92 CCL11 CCL4 CCL4L1 CXCL10

Sources for Japanese Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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45 MESH via Orphanet
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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