MCID: JPN001
MIFTS: 36

Japanese Spotted Fever

Categories: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

MalaCards integrated aliases for Japanese Spotted Fever:

Name: Japanese Spotted Fever 12 15
Rickettsia Japonica Spotted Fever 12
Oriental Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050050

Summaries for Japanese Spotted Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia japonica, which is transmitted by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary : Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to spotted fever and indian tick typhus, and has symptoms including fever, regional adenopathy and eschars. An important gene associated with Japanese Spotted Fever is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways/superpathways are Integrin Pathway and Akt Signaling. Affiliated tissues include testes, skin and liver, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 spotted fever 31.1 AFF2 CXCL10 PLEKHG4
2 indian tick typhus 10.3 AFF2 PLEKHG4
3 flinders island spotted fever 10.2 AFF2 PLEKHG4
4 endemic typhus 10.2 AFF2 PLEKHG4
5 chronic meningitis 10.2 CCL11 CRP
6 burns 10.2 CRP SERPINC1
7 blue toe syndrome 10.2 CRP SERPINC1
8 israeli tick typhus 10.2 CCL2 PLEKHG4
9 cryptosporidiosis 10.1 CCL11 CXCL10
10 carrion's disease 10.1 CCL11 CXCL10
11 subclavian steal syndrome 10.1 CRP KANTR
12 peripheral vertigo 10.1 CRP SERPINC1
13 dental abscess 10.1 CRP KANTR
14 acute pyelonephritis 10.1 CRP CXCL10
15 sphenoid sinusitis 10.1 CRP KANTR
16 intermediate coronary syndrome 10.1 CRP SERPINC1
17 ischemic heart disease 10.1 CCL2 CRP
18 scrub typhus 10.1
19 subdural empyema 10.1 CRP KANTR
20 xanthogranulomatous pyelonephritis 10.1 CCL2 CRP
21 pyelonephritis 10.1 CCL2 CRP
22 chronic eosinophilic pneumonia 10.1 CCL11 CCL2
23 angina pectoris 10.1 CRP SERPINC1
24 fungal meningitis 10.1 CCL2 CXCL10
25 leech infestation 10.1 KANTR SERPINC1
26 radiculopathy 10.1 CCL11 CCL2
27 acute cystitis 10.1 CCL2 CRP
28 posterior myocardial infarction 10.1 KANTR SERPINC1
29 subendocardial myocardial infarction 10.1 KANTR SERPINC1
30 calcific tendinitis 10.1 CRP KANTR
31 stromal keratitis 10.1 CCL2 CXCL10
32 retinal vascular occlusion 10.1 CCL2 SERPINC1
33 intermittent claudication 10.1 CRP SERPINC1
34 anterior spinal artery syndrome 10.1 KANTR SERPINC1
35 pelvic inflammatory disease 10.1 CCL2 CRP
36 post-thrombotic syndrome 10.1 CCL2 SERPINC1
37 suppurative cholangitis 10.1 CRP KANTR
38 tertiary neurosyphilis 10.1 CXCL10 KANTR
39 extrinsic cardiomyopathy 10.1 CCL2 CRP
40 branch retinal artery occlusion 10.1 KANTR SERPINC1
41 proliferative glomerulonephritis 10.1 CCL2 CXCL10
42 viral encephalitis 10.0 CCL2 CXCL10
43 pleurisy 10.0 CCL2 CRP
44 peripheral artery disease 10.0 CCL2 CRP
45 leptospirosis 10.0 CCL2 CRP
46 retinal vein occlusion 10.0 CCL2 SERPINC1
47 pneumonia 10.0 CCL11 CCL2 CRP
48 acute cervicitis 10.0 CCL4 CXCL10
49 viral meningitis 10.0 CCL2 CRP CXCL10
50 severe acute respiratory syndrome 10.0 CCL2 CRP CXCL10

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to Japanese Spotted Fever

Symptoms & Phenotypes for Japanese Spotted Fever

Symptoms:

12
  • fever
  • regional adenopathy
  • eschars
  • rash on extremities

GenomeRNAi Phenotypes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00231-A 9.02 CCL4 CXCL10
2 Decreased viability GR00342-S-3 9.02 CCL4
3 Decreased viability GR00402-S-2 9.02 CCL4 CXCL10

Drugs & Therapeutics for Japanese Spotted Fever

Search Clinical Trials , NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

Anatomical Context for Japanese Spotted Fever

MalaCards organs/tissues related to Japanese Spotted Fever:

41
Testes, Skin, Liver, Lung, Bone, Heart, Nk Cells

Publications for Japanese Spotted Fever

Articles related to Japanese Spotted Fever:

(show all 41)
# Title Authors Year
1
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
2
Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan. ( 29722440 )
2018
3
Important Clinical Features of Japanese Spotted Fever. ( 29968555 )
2018
4
Japanese spotted fever. ( 29660067 )
2018
5
Two cases of Japanese spotted fever infected in Rokko mountain near urban area of southern Hyogo Prefecture. ( 29315729 )
2018
6
Case Report: Family Cluster of Japanese Spotted Fever. ( 29363442 )
2018
7
Distinguishing Japanese Spotted Fever and Scrub Typhus, Central Japan, 2004- 2015. ( 30124190 )
2018
8
Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan. ( 30298801 )
2018
9
Japanese Spotted Fever in Eastern China, 2013. ( 30334711 )
2018
10
Geographical Distribution of Japanese Spotted Fever and Tsutsugamushi Disease in Japan - Possible Effect of Environmental Temperature. ( 28250253 )
2017
11
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. ( 26130479 )
2015
12
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. ( 24671792 )
2014
13
A neonatal case of Japanese spotted fever. ( 23743544 )
2013
14
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. ( 21668575 )
2012
15
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. ( 22466839 )
2012
16
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. ( 20553108 )
2011
17
Predictive values of clinical parameters for severe Japanese spotted fever. ( 20827564 )
2011
18
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? ( 21091673 )
2010
19
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. ( 19688250 )
2009
20
A case of Japanese spotted fever complicated with acute myocarditis. ( 17314430 )
2007
21
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. ( 17642547 )
2007
22
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. ( 16922489 )
2006
23
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. ( 16936351 )
2006
24
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. ( 16785708 )
2006
25
Severe Japanese spotted fever successfully treated with fluoroquinolone. ( 17170509 )
2006
26
Japanese spotted fever, South Korea. ( 16836831 )
2006
27
Japanese spotted fever in Korea. ( 16082011 )
2005
28
Clinical study of Japanese spotted fever and its aggravating factors. ( 12673413 )
2003
29
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. ( 12373493 )
2002
30
Japanese spotted fever involving the central nervous system: two case reports and a literature review. ( 12354906 )
2002
31
Japanese spotted fever associated with multiorgan failure. ( 11810592 )
2001
32
Fulminant Japanese spotted fever associated with hypercytokinemia. ( 11376087 )
2001
33
A patient with Japanese spotted fever complicated by meningoencephalitis. ( 11605191 )
2001
34
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. ( 11135712 )
2000
35
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. ( 10871919 )
2000
36
Japanese spotted fever cases in Kochi prefecture. ( 10777859 )
2000
37
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. ( 10783585 )
2000
38
Japanese spotted fever: report of 31 cases and review of the literature. ( 9204291 )
1997
39
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. ( 8189407 )
1994
40
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. ( 1383270 )
1992
41
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. ( 1603001 )
1992

Variations for Japanese Spotted Fever

Expression for Japanese Spotted Fever

Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for Japanese Spotted Fever

Pathways related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 CCL11 CCL2 CCL4 CCL4L1 CXCL10
2
Show member pathways
13.08 CCL11 CCL2 CCL4 CCL4L1 CXCL10 YAP1
3
Show member pathways
12.96 CCL11 CCL2 CCL4 CCL4L1 CXCL10
4
Show member pathways
12.69 CCL2 CCL4 CCL4L1 CXCL10
5
Show member pathways
12.56 CCL11 CCL2 CCL4 CCL4L1 CXCL10
6
Show member pathways
12.02 CCL11 CCL2 CXCL10
7
Show member pathways
11.87 CCL11 CCL2 CCL4 CCL4L1 CXCL10
8
Show member pathways
11.52 CCL11 CCL2 CCL4 CXCL10
9 11.41 CCL11 CCL2 CCL4
10 11.12 CCL2 CCL4 CXCL10
11 11.11 CCL11 CCL2 CCL4 CXCL10
12 11.06 CCL11 CXCL10
13 10.76 CCL11 CCL2
14 10.62 CCL11 CCL2 CCL4 CCL4L1 CXCL10
15 10.25 CCL11 CCL2 CCL4 CCL4L1 CXCL10

GO Terms for Japanese Spotted Fever

Cellular components related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CCL2 CCL4 CRP CXCL10 SERPINC1
2 extracellular space GO:0005615 9.17 CCL11 CCL2 CCL4 CCL4L1 CRP CXCL10

Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.97 CCL11 CCL2 CCL4 CCL4L1 CXCL10
2 regulation of signaling receptor activity GO:0010469 9.89 CCL11 CCL2 CCL4 CCL4L1 CXCL10
3 immune response GO:0006955 9.86 CCL11 CCL2 CCL4 CXCL10
4 inflammatory response GO:0006954 9.85 CCL11 CCL2 CCL4 CCL4L1 CRP CXCL10
5 positive regulation of GTPase activity GO:0043547 9.84 CCL11 CCL2 CCL4 CCL4L1
6 cytokine-mediated signaling pathway GO:0019221 9.83 CCL11 CCL2 CCL4 CXCL10
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 CCL11 CCL2 CCL4 CCL4L1
8 chemotaxis GO:0006935 9.78 CCL11 CCL2 CCL4 CXCL10
9 cellular response to tumor necrosis factor GO:0071356 9.76 CCL11 CCL2 CCL4 CCL4L1
10 cellular response to interferon-gamma GO:0071346 9.73 CCL11 CCL2 CCL4 CCL4L1
11 response to virus GO:0009615 9.72 CCL11 CCL4 CXCL10
12 cellular response to interleukin-1 GO:0071347 9.71 CCL11 CCL2 CCL4 CCL4L1
13 monocyte chemotaxis GO:0002548 9.62 CCL11 CCL2 CCL4 CCL4L1
14 lymphocyte chemotaxis GO:0048247 9.56 CCL11 CCL2 CCL4 CCL4L1
15 neutrophil chemotaxis GO:0030593 9.55 CCL11 CCL2 CCL4 CCL4L1 CXCL10
16 eosinophil chemotaxis GO:0048245 9.26 CCL11 CCL2 CCL4 CCL4L1
17 chemokine-mediated signaling pathway GO:0070098 9.02 CCL11 CCL2 CCL4 CCL4L1 CXCL10

Molecular functions related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CCL11 CCL2 CCL4 CXCL10
2 CCR chemokine receptor binding GO:0048020 9.26 CCL11 CCL2 CCL4 CCL4L1
3 chemokine activity GO:0008009 9.02 CCL11 CCL2 CCL4 CCL4L1 CXCL10

Sources for Japanese Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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