MCID: JPN001
MIFTS: 21

Japanese Spotted Fever

Categories: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

MalaCards integrated aliases for Japanese Spotted Fever:

Name: Japanese Spotted Fever 12 15
Rickettsia Japonica Spotted Fever 12
Oriental Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050050

Summaries for Japanese Spotted Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia japonica, which is transmitted by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary : Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to spotted fever and epidemic typhus, and has symptoms including fever, regional adenopathy and eschars. An important gene associated with Japanese Spotted Fever is AFF2 (AF4/FMR2 Family Member 2). Affiliated tissues include skin.

Wikipedia : 73 Japanese spotted fever is a condition characterized by a rash that has early macules, and later, in some... more...

Related Diseases for Japanese Spotted Fever

Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.4 PPP1R14A PLEKHG4 HTRA1 CS AFF2
2 epidemic typhus 29.1 PPP1R14A PLEKHG4 HTRA1 CS CRP AFF2
3 disseminated intravascular coagulation 10.5
4 scrub typhus 10.4
5 exanthem 10.3
6 meningoencephalitis 10.2
7 respiratory failure 10.2
8 purpura 10.2
9 adult respiratory distress syndrome 10.1
10 rickettsial disease 10.1
11 flinders island spotted fever 10.1 PLEKHG4 AFF2
12 tungiasis 10.0 PPP1R14A AFF2
13 israeli tick typhus 10.0 PPP1R14A PLEKHG4
14 glossopharyngeal nerve disease 10.0 LONP1 CRP
15 myositis 10.0
16 ocular motor apraxia 10.0
17 kawasaki disease 10.0
18 cyanosis, transient neonatal 10.0
19 proteinuria, chronic benign 10.0
20 hemophagocytic lymphohistiocytosis 10.0
21 metabolic acidosis 10.0
22 q fever 10.0
23 lyme disease 10.0
24 aseptic meningitis 10.0
25 neutropenia 10.0
26 thrombocytopenia 10.0
27 status epilepticus 10.0
28 cholecystitis 10.0
29 tularemia 10.0
30 acute myocarditis 10.0
31 systemic scleroderma 10.0
32 pneumonia 10.0
33 myocarditis 10.0
34 arthritis 10.0
35 nervous system disease 10.0
36 cytokine deficiency 10.0
37 viral hemorrhagic fever 10.0
38 meningitis and encephalitis 10.0
39 carrion's disease 10.0 PPP1R14A CS
40 spinocerebellar ataxia 1 9.9 PLEKHG4 AFF2
41 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 9.9 HTRA1 CRP
42 critical illness polyneuropathy 9.9 CS CRP
43 ornithosis 9.9 HTRA1 CRP
44 brill-zinsser disease 9.9 PLEKHG4 HSD17B14 AFF2
45 neuroretinitis 9.9 CS CRP
46 indian tick typhus 9.9 PPP1R14A PLEKHG4 AFF2
47 pediculus humanus corporis infestation 9.9 PPP1R14A CS AFF2
48 spondylosis 9.8 HTRA1 CRP
49 bacillary angiomatosis 9.8 PPP1R14A HTRA1 CS
50 queensland tick typhus 9.8 PLEKHG4 HSD17B14 CS

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to Japanese Spotted Fever

Symptoms & Phenotypes for Japanese Spotted Fever

Symptoms:

12
  • fever
  • regional adenopathy
  • eschars
  • rash on extremities

Drugs & Therapeutics for Japanese Spotted Fever

Search Clinical Trials , NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

Anatomical Context for Japanese Spotted Fever

MalaCards organs/tissues related to Japanese Spotted Fever:

40
Skin

Publications for Japanese Spotted Fever

Articles related to Japanese Spotted Fever:

(show top 50) (show all 104)
# Title Authors PMID Year
1
Diversity and distribution of ticks in Niigata prefecture, Japan (2016-2018): Changes since 1950. 61
33578257 2021
2
Growth Characteristics of Rickettsia Species LON Strains Closely Related to Rickettsia japonica Isolated from Haemaphysalis longicornis Ticks in Mouse Derived L929 and Human-Derived THP-1 Host Cell Lines. 61
32863353 2021
3
Descriptive epidemiology of rickettsial infections in Japan: Scrub typhus and Japanese spotted fever, 2007-2016. 61
33610785 2021
4
Spotted fever group rickettsiae (SFGR) detection in ticks following reported human case of Japanese spotted fever in Niigata Prefecture, Japan. 61
33510192 2021
5
Predictive variables for hemodialysis and death in Japanese spotted fever, and the association between distance from rivers and incidence. 61
33011438 2021
6
Associations between Japanese spotted fever (JSF) cases and wildlife distribution on the Boso Peninsula, Central Japan (2006-2017). 61
33012734 2020
7
Japanese spotted fever and rickettsial pneumonia. 61
33346839 2020
8
Impact of C-Reactive Protein Levels on Differentiating of Severe Fever With Thrombocytopenia Syndrome From Japanese Spotted Fever. 61
33204759 2020
9
Japanese spotted fever. 61
31851356 2020
10
Case of Japanese spotted fever infected 2 consecutive years. 61
32483854 2020
11
Preliminary Evaluation of Human Personal Protective Measures Against the Nymphal Stage of the Asian Longhorned Tick (Acari: Ixodidae). 61
32073128 2020
12
Japanese Spotted Fever with Hemophagocytic Lymphohistiocytosis. 61
31645532 2020
13
In vitro evaluation of minimum inhibitory concentration of several antibacterial agents against Rickettsia japonica using a plaque reduction assay system. 61
31186196 2019
14
Japanese Spotted Fever: A Rare Cause of Arthritis. 61
30918201 2019
15
Diversity of spotted fever group rickettsiae and their association with host ticks in Japan. 61
30728409 2019
16
Genomic Features of Rickettsia heilongjiangensis Revealed by Intraspecies Comparison and Detailed Comparison With Rickettsia japonica. 61
31866968 2019
17
Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan. 61
30298801 2018
18
Japanese Spotted Fever in Eastern China, 2013. 61
30334711 2018
19
Rickettsia japonica Infections in Humans, Zhejiang Province, China, 2015. 61
30334710 2018
20
Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan. 61
29722440 2018
21
Japanese spotted fever. 61
29660067 2018
22
Distinguishing Japanese Spotted Fever and Scrub Typhus, Central Japan, 2004- 2015. 61
30124190 2018
23
Important Clinical Features of Japanese Spotted Fever. 61
29968555 2018
24
Distribution of tick-borne diseases in Japan: Past patterns and implications for the future. 61
29685854 2018
25
Serological Cross-Reactivity among Orientia tsutsugamushi Serotypes but Not with Rickettsia japonica in Japan. 61
30274470 2018
26
Evaluation of Diagnostic Assay for Rickettsioses Using Duplex Real-Time PCR in Multiple Laboratories in Japan. 61
29709963 2018
27
Two cases of Japanese spotted fever infected in Rokko mountain near urban area of southern Hyogo Prefecture. 61
29315729 2018
28
Case Report: Family Cluster of Japanese Spotted Fever. 61
29363442 2018
29
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. 61
29021432 2018
30
Geographical Distribution of Japanese Spotted Fever and Tsutsugamushi Disease in Japan - Possible Effect of Environmental Temperature. 61
28250253 2017
31
Extremely Low Genomic Diversity of Rickettsia japonica Distributed in Japan. 61
28057731 2017
32
[Severe Japanese Spotted Fever Complicated by Acute Respiratory Failure in Kobe City]. 61
27197438 2016
33
Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan. 61
26551325 2016
34
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. 61
26130479 2015
35
[Intravenous Minocycline and Levofloxacin for Treatment of Two Cases of Japanese Spotted Fever]. 61
26630793 2015
36
[Clinical Manifestations of Japanese Spotted Fever: Multi-institution Study in Endemic Areas in Japan]. 61
26554228 2015
37
Detection of rickettsial DNA in ticks and wild boars in Kyoto City, Japan. 61
25298315 2015
38
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. 61
24671792 2014
39
Higher sika deer density is associated with higher local abundance of Haemaphysalis longicornis nymphs and adults but not larvae in central Japan. 61
23702338 2014
40
A neonatal case of Japanese spotted fever. 61
23743544 2013
41
Ticks (Acari: Ixodidae) from medium-sized to large mammals in Ehime Prefecture, Japan. 61
23242932 2013
42
Complete genomic DNA sequence of the East Asian spotted fever disease agent Rickettsia japonica. 61
24039725 2013
43
Genomic analysis of Rickettsia japonica strain YHT. 61
23209240 2012
44
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. 61
21668575 2012
45
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. 61
22466839 2012
46
[Clinical investigation of nine pediatric Japanese spotted fever cases]. 61
22250454 2011
47
Predictive values of clinical parameters for severe Japanese spotted fever. 61
20827564 2011
48
[Knowledge and attitude in medical behavior in Japanese spotted fever in endemic and non-endemic areas]. 61
21560423 2011
49
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. 61
20553108 2011
50
The diagnostic usefulness of dermoscopy for identifying six-legged larval ticks. 61
21771529 2010

Variations for Japanese Spotted Fever

Expression for Japanese Spotted Fever

Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for Japanese Spotted Fever

GO Terms for Japanese Spotted Fever

Sources for Japanese Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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