MCID: JWC001
MIFTS: 37

Jaw Cancer

Categories: Bone diseases, Cancer diseases, Oral diseases

Aliases & Classifications for Jaw Cancer

MalaCards integrated aliases for Jaw Cancer:

Name: Jaw Cancer 12 15
Jaw Neoplasms 44 73
Neoplasm of Jaw 12
Cancer of Jaw 73
Jaw Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1862
MeSH 44 D007573
SNOMED-CT 68 126634001

Summaries for Jaw Cancer

Disease Ontology : 12 A bone cancer and jaw disease that is located in the jaw and results in a swollen jaw, results in numbness or a tingling sensation in jaw, and results in an abnormal growth of the jaw bone.

MalaCards based summary : Jaw Cancer, also known as jaw neoplasms, is related to mandibular cancer and maxillary neoplasm. An important gene associated with Jaw Cancer is ST7 (Suppression Of Tumorigenicity 7), and among its related pathways/superpathways are Regulation of IFNA signaling and Tuberculosis. The drugs Bupivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include the jaw, bone and testes, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Jaw Cancer

Diseases related to Jaw Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 mandibular cancer 27.3 CEP70 CSF1 CTSL CTSS GFAP SERPINB5
2 maxillary neoplasm 10.8
3 extraskeletal chondroma 10.6 PTH PTHLH
4 sclerosing hepatic carcinoma 10.6 PTH PTHLH
5 invasive malignant thymoma 10.6 PTH PTHLH
6 hypocalciuric hypercalcemia, familial, type iii 10.6 PTH PTHLH
7 clear cell adenoma 10.6 PTH PTHLH
8 syringoma 10.6 GFAP SERPINB5
9 leukoregulin 10.6 CSF1 IL1A
10 oncogenic osteomalacia 10.6 PTH PTHLH
11 lipoadenoma 10.5 PTH SERPINB5
12 hypercalcemia, infantile, 1 10.5 PTH PTHLH
13 multicentric reticulohistiocytosis 10.5 CSF1 TNFSF11
14 stachybotrys chartarum 10.4 CSF1 IL1A
15 tooth ankylosis 10.4 PTHLH TNFSF11
16 postsurgical hypothyroidism 10.4 CSF3 PTH
17 pigmented villonodular synovitis 10.4 CSF1 TNFSF11
18 pseudohypoparathyroidism, type ib 10.3 PTH PTHLH
19 multicentric carpotarsal osteolysis syndrome 10.3 PTHLH TNFSF11
20 cerebral neuroblastoma 10.3 CSF3 GFAP
21 clonorchiasis 10.3 CTSL IFNG
22 chondroblastoma 10.2 PTHLH TNFSF11
23 chronic graft versus host disease 10.2 IFNG IL1A
24 fascioliasis 10.2 CTSL IFNG
25 paget's disease of bone 10.2 CSF1 PTH TNFSF11
26 cloacogenic carcinoma 10.2 PTH PTHLH
27 dysgerminoma of ovary 10.2 GFAP PTHLH
28 trichosporonosis 10.1 CSF3 IFNG
29 cyclic neutropenia 10.0 CSF3 IFNG
30 langerhans cell histiocytosis 9.9 CSF1 IFNG TNFSF11
31 glucocorticoid-induced osteoporosis 9.9 PTH TNFSF11
32 bone disease 9.8 CSF1 PTH PTHLH TNFSF11
33 osteomyelitis 9.8 IFNG IL1A TNFSF11
34 bone inflammation disease 9.8 IFNG IL1A TNFSF11
35 periodontitis 9.8 IFNG IL1A TNFSF11
36 medulloblastoma 9.7
37 myofibroma 9.7
38 cerebellopontine angle tumor 9.7 CTSS GFAP
39 periodontosis 9.6 CTSS TNFSF11
40 aseptic meningitis 9.5 IFNG IL1A
41 arthritis 9.4 CSF1 IFNG IL1A TNFSF11
42 rheumatoid arthritis 9.1 CSF1 CTSL IFNG IL1A TNFSF11
43 osteoporosis 8.7 CSF1 IFNG IL1A PTH PTHLH TNFSF11

Graphical network of the top 20 diseases related to Jaw Cancer:



Diseases related to Jaw Cancer

Symptoms & Phenotypes for Jaw Cancer

MGI Mouse Phenotypes related to Jaw Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.92 GFAP IFNG NEK8 PTHLH SERPINB5 TNFSF11
2 cardiovascular system MP:0005385 9.86 CSF1 CTSS GFAP IFNG IL1A NEK8
3 hematopoietic system MP:0005397 9.81 PTH PTHLH SERPINB5 TNFSF11 CSF1 CSF3
4 immune system MP:0005387 9.61 CSF1 CSF3 CTSS GFAP IFNG IL1A
5 respiratory system MP:0005388 9.1 CSF1 CTSS IFNG NEK8 PTHLH TNFSF11

Drugs & Therapeutics for Jaw Cancer

Drugs for Jaw Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
2 Anesthetics Not Applicable
3 Anesthetics, Local Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Inferior Alveolar Nerve Block for Intraoperative Analgesia for Maxillofacial Cancer Surgery - RCT Completed NCT02745288 Not Applicable
2 Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making Recruiting NCT03239834
3 Three-Dimensional Printing of Patient-Specific Titanium Plates in Jaw Surgery: A Pilot Study Recruiting NCT03057223 Not Applicable

Search NIH Clinical Center for Jaw Cancer

Cochrane evidence based reviews: jaw neoplasms

Genetic Tests for Jaw Cancer

Anatomical Context for Jaw Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Jaw Cancer:

19
The Jaw

MalaCards organs/tissues related to Jaw Cancer:

41
Bone, Testes

Publications for Jaw Cancer

Articles related to Jaw Cancer:

# Title Authors Year
1
Assessment of the quality of life in patients with oral cavity and jaw cancer in three regions of Bulgaria. ( 17918295 )
2007
2
Testing your diagnostic skills. Case No. 1: a relatively rare jaw neoplasm called a myofibroma. ( 17708027 )
2006

Variations for Jaw Cancer

Expression for Jaw Cancer

Search GEO for disease gene expression data for Jaw Cancer.

Pathways for Jaw Cancer

Pathways related to Jaw Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 CSF3 GFAP IFNG IL1A
2 12 CTSS IFNG IL1A
3
Show member pathways
11.95 CTSL CTSS IFNG
4 11.87 CTSL IFNG IL1A
5 11.78 GFAP IFNG IL1A
6 11.75 CSF1 CSF3 IFNG
7 11.68 PTH PTHLH TNFSF11
8 11.67 CSF1 IFNG IL1A TNFSF11
9 11.62 CSF1 CSF3 IL1A
10 11.27 CSF1 CSF3 IL1A
11 11.23 CSF1 CSF3 IL1A
12 11.11 IFNG IL1A PTH TNFSF11
13 11.09 PTH PTHLH TNFSF11
14 10.98 CSF1 CTSL IFNG IL1A TNFSF11
15 10.84 IFNG IL1A
16 10.73 CSF1 CSF3 IFNG IL1A
17 10.64 PTH TNFSF11

GO Terms for Jaw Cancer

Cellular components related to Jaw Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CSF1 CSF3 CTSL CTSS IFNG IL1A
2 extracellular space GO:0005615 9.32 CSF1 CSF3 CTSL CTSS IFNG IL1A
3 endolysosome lumen GO:0036021 9.16 CTSL CTSS

Biological processes related to Jaw Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 CSF3 CTSS IFNG IL1A TNFSF11
2 cytokine-mediated signaling pathway GO:0019221 9.67 CSF1 CSF3 IL1A TNFSF11
3 osteoclast differentiation GO:0030316 9.52 CSF1 TNFSF11
4 homeostasis of number of cells within a tissue GO:0048873 9.51 CSF1 PTH
5 bone resorption GO:0045453 9.49 PTH TNFSF11
6 macrophage differentiation GO:0030225 9.48 CSF1 CSF3
7 negative regulation of chondrocyte differentiation GO:0032331 9.46 PTH PTHLH
8 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.43 PTH PTHLH
9 cellular response to thyroid hormone stimulus GO:0097067 9.4 CTSL CTSS
10 cAMP metabolic process GO:0046058 9.26 PTH PTHLH
11 regulation of signaling receptor activity GO:0010469 9.17 CSF1 CSF3 IFNG IL1A PTH PTHLH
12 osteoclast proliferation GO:0002158 9.16 CSF1 TNFSF11
13 positive regulation of osteoclast differentiation GO:0045672 9.13 CSF1 IFNG TNFSF11

Molecular functions related to Jaw Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibronectin binding GO:0001968 9.26 CTSL CTSS
2 proteoglycan binding GO:0043394 9.16 CTSL CTSS
3 cytokine activity GO:0005125 9.02 CSF1 CSF3 IFNG IL1A TNFSF11
4 peptide hormone receptor binding GO:0051428 8.96 PTH PTHLH

Sources for Jaw Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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