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MCID: JJN007
MIFTS: 30

Jejunal Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Jejunal Adenocarcinoma

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MalaCards integrated aliases for Jejunal Adenocarcinoma:

Name: Jejunal Adenocarcinoma 12 15 70

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050926
UMLS 70 C4072935
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Summaries for Jejunal Adenocarcinoma

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Disease Ontology : 12 A jejunal cancer that is located in the jejunum and has material basis in epithelial tissue that has glandular origin.

MalaCards based summary : Jejunal Adenocarcinoma is related to intestinal obstruction and adenocarcinoma. An important gene associated with Jejunal Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are DNA Double-Strand Break Repair and DNA Damage. Affiliated tissues include jejunum, small intestine and colon, and related phenotypes are cellular and neoplasm

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Related Diseases for Jejunal Adenocarcinoma

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Diseases related to Jejunal Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 intestinal obstruction 30.0 KRT7 KRT20 CDX2
2 adenocarcinoma 29.9 MSH6 MLH1 KRT7 KRT20 CDX2
3 small intestine adenocarcinoma 29.7 PMS2 MSH6 MLH1
4 appendix adenocarcinoma 29.7 KRT7 KRT20 CDX2
5 gastrointestinal carcinoma 29.7 KRT20 CDX2
6 lynch syndrome i 29.5 PMS2 MSH6 MLH1
7 gastric adenocarcinoma 29.4 MLH1 KRT20 CDX2
8 familial adenomatous polyposis 29.2 MUTYH MSH6 MLH1
9 mucinous adenocarcinoma 29.2 MLH1 KRT7 KRT20 CDX2
10 lynch syndrome 29.0 PMS2 MUTYH MSH6 MLH1
11 sebaceous adenoma 28.8 PMS2 MUTYH MSH6 MLH1
12 muir-torre syndrome 28.5 PMS2 MUTYH MSH6 MLH1 KRT7
13 adenoma 28.2 MUTYH MSH6 MLH1 KRT7 KRT20 CDX2
14 jejunal cancer 27.7 PMS2 MUTYH MSH6 MLH1 KRT7 KRT20
15 bile duct adenoma 10.2 KRT7 KRT20
16 cystadenoma 10.2 KRT7 KRT20
17 clear cell adenocarcinoma 10.2 KRT7 KRT20
18 urethral villous adenoma 10.2 KRT7 KRT20
19 bladder benign neoplasm 10.2 KRT7 KRT20
20 nephrogenic adenoma of urinary bladder 10.2 KRT7 KRT20
21 atrophic vulva 10.2 KRT7 KRT20
22 pancreatic serous cystadenocarcinoma 10.2 KRT7 KRT20
23 renal pelvis carcinoma 10.2 MSH6 KRT7
24 rectosigmoid junction neoplasm 10.2 KRT7 KRT20
25 urinary bladder small cell neuroendocrine carcinoma 10.2 KRT7 KRT20
26 vulvar apocrine adenocarcinoma 10.2 KRT7 KRT20
27 eyelid carcinoma 10.2 KRT7 KRT20
28 jejunal neoplasm 10.2 KRT7 KRT20
29 colonic lymphangioma 10.2 KRT7 KRT20
30 intratubular embryonal carcinoma 10.2 KRT7 KRT20
31 malignant syringoma 10.2 KRT7 KRT20
32 ovarian large-cell neuroendocrine carcinoma 10.2 KRT7 KRT20
33 papillary transitional carcinoma 10.2 KRT7 KRT20
34 supine hypotensive syndrome 10.2 KRT7 KRT20
35 meibomian cyst 10.2 KRT7 KRT20
36 acute orbital inflammation 10.2 KRT7 KRT20
37 eccrine sweat gland cancer 10.2 KRT7 KRT20
38 sweat gland cancer 10.2 KRT7 KRT20
39 nephrogenic adenoma of the urethra 10.2 KRT7 KRT20
40 pancreatic mucinous cystadenoma 10.2 KRT7 KRT20
41 intussusception 10.2
42 squamous papillomatosis 10.2 KRT7 KRT20
43 ovarian brenner tumor 10.2 KRT7 KRT20
44 lung leiomyosarcoma 10.2 KRT7 KRT20
45 ovary neuroendocrine neoplasm 10.2 KRT7 CDX2
46 prostate neuroendocrine neoplasm 10.2 KRT7 KRT20
47 bladder lateral wall cancer 10.2 KRT7 KRT20
48 anal canal paget's disease 10.2 KRT7 CDX2
49 anal paget's disease 10.2 KRT7 CDX2
50 gastric signet ring cell adenocarcinoma 10.2 KRT7 CDX2

Graphical network of the top 20 diseases related to Jejunal Adenocarcinoma:



Diseases related to Jejunal Adenocarcinoma
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Symptoms & Phenotypes for Jejunal Adenocarcinoma

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MGI Mouse Phenotypes related to Jejunal Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 CDX2 KRT7 MLH1 MSH6 MUTYH PMS2
2 neoplasm MP:0002006 9.02 CDX2 MLH1 MSH6 MUTYH PMS2
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Drugs & Therapeutics for Jejunal Adenocarcinoma

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Search Clinical Trials , NIH Clinical Center for Jejunal Adenocarcinoma

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Genetic Tests for Jejunal Adenocarcinoma

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Anatomical Context for Jejunal Adenocarcinoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Jejunal Adenocarcinoma:

19
Jejunum

MalaCards organs/tissues related to Jejunal Adenocarcinoma:

40
Small Intestine, Colon, Pancreas
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Publications for Jejunal Adenocarcinoma

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Articles related to Jejunal Adenocarcinoma:

(show top 50) (show all 95)
# Title Authors PMID Year
1
Jejunal Adenocarcinoma as a Rare Cause of Small Bowel Obstruction: A Case Report. 61
33154836 2020
2
A case of small bowel adenocarcinoma wherein nivolumab conferred temporary benefit in disease control. 61
31701367 2020
3
Obscure gastrointestinal bleeding with negative abdominal computed tomography study: The importance of enteroscopy for early diagnosis of small bowel malignancy. 61
32055704 2020
4
Rare presentation of small bowel adenocarcinoma with neuroendocrine differentiation in the jejunum: A case report and summary of diagnostic and management options. 61
31616561 2019
5
Stage IV jejunal adenocarcinoma: a multimodal therapeutic success story. 61
31462984 2019
6
Second jejunal loop adenocarcinoma associated with celiac disease: the first case report. 61
31484013 2019
7
A 53-Year-Old Man Presenting With Diplopia and Cavitary Lung Nodules. 61
30955581 2019
8
Adenocarcinoma of jejunum. 61
30181864 2018
9
Primary Jejunal adenocarcinoma - An unsuspected culprit. 61
29540890 2018
10
[A case of jejunal neuroendocrine carcinoma complicated with dermatomyositis]. 61
30531112 2018
11
A Challenging Diagnosis of Jejunal Adenocarcinoma in a Celiac Patient: Case Report and Systematic Review of the Literature. 61
29253057 2017
12
Primary Jejunal Adenocarcinoma Presenting as Bilateral Ovarian Metastasis. 61
29317945 2017
13
Metastatic Ovarian Tumors Originating From a Small Bowel Adenocarcinoma - A Case Report and Brief Literature Review. 61
27513076 2017
14
Small bowel adenocarcinoma arising in a patient with hereditary hemorrhagic telangiectasia: A case report. 61
26998137 2016
15
Adult jejunojejunal intussusception in the face of jejunal adenocarcinoma: two infrequently encountered entities. 61
26961563 2016
16
Computed Tomographic presentation of obstructive jejunal adenocarcinoma associated with celiac disease and incomplete intestinal malrotation. 61
26670410 2016
17
Surgical management of small intestinal intussusception associated with jejunal adenocarcinoma in a dairy cow. 61
25530282 2015
18
Jejunal adenocarcinoma with cutaneous metastasis. 61
26436979 2015
19
[Robot-assisted resection of duodenal inferior horizontal part and duodeno-jejunal transition]. 61
26031948 2015
20
[A case of long-term survival of small intestinal adenocarcinoma treated by resection and chemotherapy]. 61
25731553 2014
21
Gastrointestinal tract obstruction due to jejunal adenocarcinoma--case report. 61
24988236 2014
22
Jejunal adenocarcinoma with concomitant enterolith presenting as acute intestinal obstruction. 61
24717991 2014
23
Jejunal adenocarcinoma-a case report with review. 61
24426522 2013
24
Challenging diagnosis of a jejunal adenocarcinoma with ovarian metastasis: report of an unusual case. 61
23580681 2013
25
Primary jejunal adenocarcinoma incidentally diagnosed on positron emission tomography/computed tomography in a patient with metastatic colorectal cancer: suspicion of Lynch syndrome and effect on therapeutic management. 61
23341528 2013
26
Prospective enteroscopic evaluation of jejunal polyposis in patients with familial adenomatous polyposis and advanced duodenal polyposis. 61
23054214 2013
27
Jejunal adenocarcinoma: an elusive diagnosis. 61
22942611 2011
28
Familial adenomatous polyposis with synchronous invasive colonic carcinomas and metastatic jejunal adenocarcinoma in a Nigerian male. 61
21234258 2010
29
Intussusception and volvulus secondary to jejunal adenocarcinoma in an adult Nigerian male: a case report. 61
21220868 2010
30
[A case of jejunal adenocarcinoma with serum DUPAN-2 elevation]. 61
21071898 2010
31
Metastatic Small Intestinal Cancer of the Urinary Bladder. 61
21060770 2010
32
Atypical identification of Lynch syndrome by immunohistochemistry and microsatellite instability analysis on jejunal adenocarcinoma. 61
20379851 2010
33
Double primary adenocarcinomas of the jejunum and descending colon with lung metastases presenting rare immunohistochemical phenotypes: a case report. 61
19923997 2010
34
A case of jejunal adenocarcinoma diagnosed by preoperative double balloon enteroscopy. 61
20431766 2009
35
Peutz-Jeghers syndrome and duodeno-jejunal adenocarcinoma--therapeutic implications. 61
20082550 2009
36
[Adenocarcinoma of the small intestines complicating coeliac disease in an adult: case report]. 61
19777919 2009
37
Multimedia articles. Small-bowel tumors with extensive mesenteric involvement can be resected with careful dissection of the mesenteric vessels with good outcomes. 61
19581866 2009
38
Blood loss anemia due to adenocarcinoma of the jejunum: case report and review of the literature. 61
19918564 2009
39
Small bowel polyps and tumours: endoscopic detection and treatment by double-balloon enteroscopy. 61
18945259 2009
40
Complications and follow-up after pancreas-preserving total duodenectomy for duodenal polyps. 61
18991295 2008
41
Jejunojejunal intussusception by a known jejunal adenocarcinoma. 61
18815635 2008
42
Jejunal adenocarcinoma: still an elusive diagnosis. Case report and review of the literature. 61
18709788 2008
43
Primary jejunal adenocarcinoma as part of multiple primary cancers of the digestive tract. 61
18397495 2008
44
[Jejunal adenocarcinoma: a difficult diagnostic entity]. 61
18358183 2008
45
Preoperative diagnosis of jejunal adenocarcinoma--a case report. 61
18404799 2008
46
Oxaliplatin/5-fluorouracil/leucovorin (FOLFOX4) regimen as an adjuvant chemotherapy in the treatment of advanced jejunal adenocarcinoma: a report of 2 cases. 61
18836281 2008
47
Early experience with double balloon enteroscopy: a leap forward for the gastroenterologist. 61
17245517 2007
48
Intestinal neoplasia in horses. 61
17186861 2006
49
[A case of primary jejunal adenocarcinoma diagnosed by enteroscopy using pediatric colonoscope]. 61
17132927 2006
50
Jejunal adenocarcinoma: a rare cause of chronic anemia in children. 61
16385262 2006
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Variations for Jejunal Adenocarcinoma

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Expression for Jejunal Adenocarcinoma

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Search GEO for disease gene expression data for Jejunal Adenocarcinoma.
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Pathways for Jejunal Adenocarcinoma

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Pathways related to Jejunal Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
DNA Double-Strand Break Repair 65
Show member pathways
 12.56 PMS2 MUTYH MSH6 MLH1
2
DNA Damage 4
11.8 MUTYH MSH6 MLH1
3
Mismatch repair 1 36 65
Show member pathways
 11.11 PMS2 MSH6 MLH1
4
Platinum Pathway, Pharmacokinetics/Pharmacodynamics 60
10.26 PMS2 MSH6 MLH1
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GO Terms for Jejunal Adenocarcinoma

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Cellular components related to Jejunal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 condensed nuclear chromosome GO:0000794 9.16 MLH1 CDX2
2 MutLalpha complex GO:0032389 8.96 PMS2 MLH1
3 mismatch repair complex GO:0032300 8.8 PMS2 MSH6 MLH1

Biological processes related to Jejunal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.62 PMS2 MUTYH MSH6 MLH1
2 DNA repair GO:0006281 9.56 PMS2 MUTYH MSH6 MLH1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.4 MSH6 MLH1
4 isotype switching GO:0045190 9.37 MSH6 MLH1
5 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MSH6 MLH1
6 somatic hypermutation of immunoglobulin genes GO:0016446 9.13 PMS2 MSH6 MLH1
7 mismatch repair GO:0006298 8.92 PMS2 MUTYH MSH6 MLH1

Molecular functions related to Jejunal Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.54 PMS2 MSH6 MLH1
2 MutLalpha complex binding GO:0032405 9.32 MUTYH MSH6
3 oxidized purine DNA binding GO:0032357 9.26 MUTYH MSH6
4 guanine/thymine mispair binding GO:0032137 9.16 MSH6 MLH1
5 mismatched DNA binding GO:0030983 9.13 PMS2 MSH6 MLH1
6 MutSalpha complex binding GO:0032407 8.8 PMS2 MUTYH MLH1
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Sources for Jejunal Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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