MCID: JJN003
MIFTS: 37

Jejunal Cancer

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Jejunal Cancer

MalaCards integrated aliases for Jejunal Cancer:

Name: Jejunal Cancer 11 14 16
Jejunal Neoplasms 43 71 75
Malignant Neoplasm of Jejunum 11 71
Malignant Tumor of Jejunum 11

Classifications:



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Disease Ontology 11 DOID:13499
ICD9CM 34 152.1
MeSH 43 D007580
NCIt 49 C170919
SNOMED-CT 68 93846004
ICD10 31 C17.1
UMLS 71 C0022374 C0153427

Summaries for Jejunal Cancer

MalaCards based summary: Jejunal Cancer, also known as jejunal neoplasms, is related to jejunal adenocarcinoma and small intestine benign neoplasm. An important gene associated with Jejunal Cancer is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Homology Directed Repair and Homologous DNA Pairing and Strand Exchange. Affiliated tissues include small intestine, colon and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia: 75 Small intestine cancer is a cancer of the small intestine. It is relatively rare compared to other... more...

Related Diseases for Jejunal Cancer

Diseases related to Jejunal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 jejunal adenocarcinoma 30.2 PMS2 MUTYH MSH6 MSH2 MLH1 KRT7
2 small intestine benign neoplasm 29.9 CHGA CDX2
3 myh-associated polyposis 29.8 MUTYH MSH2
4 lynch syndrome i 29.3 PMS2 MSH6 MSH2 MLH1
5 familial adenomatous polyposis 29.3 PMS2 MUTYH MSH6 MSH2 MLH1
6 desmoid tumor 29.1 PMS2 MUTYH MSH6 MSH2
7 small intestine adenocarcinoma 28.8 PMS2 MSH6 MSH2 MLH1 KRT7 CDX2
8 colorectal adenoma 28.5 PMS2 MUTYH MSH6 MSH2 MLH1 CEACAM5
9 ascending colon cancer 28.4 PMS2 MSH6 MSH2 MLH1 KRT7 CEACAM5
10 colonic benign neoplasm 28.1 PMS2 MUTYH MSH6 MSH2 MLH1 KRT7
11 small intestine cancer 28.1 PMS2 MUTYH MSH6 MSH2 MLH1 KRT7
12 adenocarcinoma 28.1 MSH6 MSH2 MLH1 KRT7 CHGA CEACAM5
13 lynch syndrome 27.9 PMS2 MUTYH MSH6 MSH2 MLH1 KRT7
14 adenoma 27.9 PMS2 MUTYH MSH6 MSH2 MLH1 KRT7
15 spindle cell intraocular melanoma 10.2 PMS2 MLH1
16 bladder signet ring cell adenocarcinoma 10.2 KRT7 CDX2
17 ovary neuroendocrine neoplasm 10.2 KRT7 CDX2
18 anal canal paget's disease 10.2 KRT7 CDX2
19 seminal vesicle adenocarcinoma 10.2 KRT7 CDX2
20 anal gland adenocarcinoma 10.2 KRT7 CDX2
21 nasal cavity adenocarcinoma 10.2 KRT7 CDX2
22 anus adenocarcinoma 10.2 KRT7 CDX2
23 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT7 CDX2
24 anal canal adenocarcinoma 10.2 KRT7 CDX2
25 gastric signet ring cell adenocarcinoma 10.2 KRT7 CDX2
26 bladder urachal carcinoma 10.2 KRT7 CDX2
27 rectum neuroendocrine neoplasm 10.2 KRT7 CDX2
28 breast hemangioma 10.2 KRT7 CDX2
29 urachus cancer 10.2 KRT7 CDX2
30 cystitis cystica 10.2 KRT7 CDX2
31 sublingual gland cancer 10.2 KRT7 CDX2
32 breast mucinous carcinoma 10.2 KRT7 CDX2
33 ovarian seromucinous carcinoma 10.2 KRT7 CDX2
34 gallbladder signet ring cell adenocarcinoma 10.2 KRT7 CDX2
35 colorectal cancer, hereditary nonpolyposis, type 4 10.2 PMS2 MLH1
36 laryngeal mucoepidermoid carcinoma 10.2 CEACAM5 CDX2
37 glandular cystitis 10.2 KRT7 CDX2
38 thymus adenocarcinoma 10.2 CEACAM5 CDX2
39 bladder clear cell adenocarcinoma 10.2 KRT7 CDX2
40 bartholin's gland carcinoma 10.2 KRT7 CDX2
41 gallbladder carcinoma in situ 10.2 CEACAM5 CDX2
42 periampullary adenocarcinoma 10.2 KRT7 CDX2
43 ovarian cyst 10.2 MSH2 CEACAM5
44 cystic basal cell carcinoma 10.2 KRT7 CDX2
45 epididymis adenocarcinoma 10.1 KRT7 CDX2
46 epididymis cancer 10.1 KRT7 CDX2
47 anus basaloid carcinoma 10.1 KRT7 CDX2
48 lentigines 10.1 MSH2 MLH1
49 cervical endometrioid adenocarcinoma 10.1 MSH6 MSH2
50 chronic cystitis 10.1 KRT7 CDX2

Comorbidity relations with Jejunal Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Intestinal Obstruction

Graphical network of the top 20 diseases related to Jejunal Cancer:



Diseases related to Jejunal Cancer

Symptoms & Phenotypes for Jejunal Cancer

GenomeRNAi Phenotypes related to Jejunal Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.5 MLH1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.5 MLH1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.5 MLH1 MSH2 MSH6 MUTYH PMS2
4 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.32 MSH6

MGI Mouse Phenotypes related to Jejunal Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 CDX2 CEACAM5 CHGA KRT7 MLH1 MSH2
2 neoplasm MP:0002006 9.87 CDX2 CEACAM5 MLH1 MSH2 MSH6 MUTYH
3 cellular MP:0005384 9.56 CDX2 CEACAM5 KRT7 MLH1 MSH2 MSH6
4 digestive/alimentary MP:0005381 9.55 CDX2 CEACAM5 MLH1 MSH2 PMS2
5 mortality/aging MP:0010768 9.23 CDX2 CEACAM5 CHGA MLH1 MSH2 MSH6

Drugs & Therapeutics for Jejunal Cancer

Search Clinical Trials, NIH Clinical Center for Jejunal Cancer

Cochrane evidence based reviews: jejunal neoplasms

Genetic Tests for Jejunal Cancer

Anatomical Context for Jejunal Cancer

Organs/tissues related to Jejunal Cancer:

MalaCards : Small Intestine, Colon, Lung, Pancreas, Brain

Publications for Jejunal Cancer

Articles related to Jejunal Cancer:

(show all 44)
# Title Authors PMID Year
1
Pancreas-preserving total duodenectomy for advanced duodenal polyposis in patients with familial adenomatous polyposis: short and long-term outcomes. 62
35568653 2022
2
Extracolonic tumours in a pedigree with EPCAM-related Lynch Syndrome. 62
35367635 2022
3
Rare case of early jejunal cancer with laterally spreading tumor-like appearance. 62
34657334 2022
4
[A Case of Primary Jejunal Cancer Treated with Laparoscopic Jejunectomy with Appearance of Ileus]. 62
35046276 2021
5
Double-balloon endoscopy facilitates efficient endoscopic resection of duodenal and jejunal polyps in patients with familial adenomatous polyposis. 62
32464675 2021
6
Minimally invasive surgery with adenocarcinoma of jejunum diagnosed pathologically before surgery: A case report. 62
33508617 2021
7
Laparoscopic duodenojejunostomy requiring a side-to-side jejunojejunostomy in malignant stenosis of the gastrojejunal anastomosis in jejunal cancer: A case report. 62
32846278 2020
8
A sequentially metastatic gastric and jejunal cancer originating from colon cancer: A case report. 62
32470913 2020
9
Late metastatic colon cancer masquerading as primary jejunal carcinoma. 62
26890851 2016
10
PIK3CA mutations in small bowel adenocarcinoma. 62
25908046 2015
11
[A case of primary micropapillary carcinoma of the jejunum]. 62
25759227 2015
12
[A case of Lynch syndrome with advanced jejunal cancer]. 62
25373375 2014
13
[A case of an elderly patient who underwent single-incision laparoscopic surgery for small intestine cancer]. 62
25731551 2014
14
Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview. 62
25018888 2014
15
[A case of cancer in the dilated jejunal pouch after total gastrectomy]. 62
24393901 2013
16
Successful treatment of primary jejunal cancer after esophageal and colon cancer resection. 62
24620639 2013
17
[A case of jejnal cancer who was controlled peritoneal metastasis, successfully by combination therapy with docetaxel and S-1]. 62
24393899 2013
18
[A case of small intestinal cancer with peritoneal metastases treated with FOLFOX regimen]. 62
22902454 2012
19
Response to jejunal cancer in patients with familial adenomatous polyposis. 62
21182984 2011
20
Jejunal cancer detected after a resection of bilateral ovarian metastasis: report of a case. 62
21046510 2010
21
Jejunal cancer in patients with familial adenomatous polyposis. 62
20621624 2010
22
Metastatic Small Intestinal Cancer of the Urinary Bladder. 62
21060770 2010
23
Jejunal cancer in patients with familial adenomatous polyposis. 62
20399906 2010
24
[A case of locally invasive obstructive jejunal cancer with curative resection after stenting and chemotherapy]. 62
20664318 2010
25
Double primary adenocarcinomas of the jejunum and descending colon with lung metastases presenting rare immunohistochemical phenotypes: a case report. 62
19923997 2010
26
Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case. 62
19404084 2009
27
A case of primary jejunal cancer diagnosed by preoperative small intestinal endoscopy. 62
21318964 2008
28
Education and imaging. Gastrointestinal: metallic stent for an obstructing jejunal cancer. 62
17074030 2006
29
Primary jejunal cancer. 62
16246696 2005
30
Huge ovarian metastasis from jejunal cancer occurring immediately after initial operation. 62
15816449 2005
31
[Case with double primary cancers occurring synchronously in both the lung and jejunum diagnosed according to TTF-1 expression]. 62
15770938 2005
32
[Multiple jejunal cancer diagnosed as a consequence of severe anemia]. 62
14968589 2004
33
Stereotactic radiosurgery for brain metastases from gastrointestinal tract cancer. 62
14670663 2003
34
The diagnosis and treatment of adult intussusception. 62
12488701 2003
35
Primary jejunal adenocarcinoma masquerading as a primary ovarian malignancy. 62
7789880 1995
36
Taxol and platinum chemotherapy in the treatment of pancreatic and jejunal carcinoma. 62
7609530 1995
37
Duodeno-jejunal tumors. Report of 9 cases and literature review. 62
8154664 1993
38
Two sisters with coeliac disease and jejunal cancer: just a coincidence? 62
8446219 1993
39
[Case of jejunal cancer]. 62
5692020 1968
40
[4 Cases of jejunal cancer]. 62
13598323 1958
41
[Fistulized jejunal cancer in the transverse colon]. 62
13408674 1956
42
[Clinically silent jejunal cancer detected by radiography without preparation]. 62
13315832 1956
43
[Generalized pulmonary carcinomatosis secondary to jejunal cancer]. 62
14935836 1952
44
Jejunal cancer; a case report. 62
20992565 1946

Variations for Jejunal Cancer

Expression for Jejunal Cancer

Search GEO for disease gene expression data for Jejunal Cancer.

Pathways for Jejunal Cancer

Pathways related to Jejunal Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 PMS2 MUTYH MSH6 MSH2 MLH1
2
Show member pathways
12.31 PMS2 MUTYH MSH6 MSH2 MLH1
3 12.14 MUTYH MSH6 MSH2 MLH1
4
Show member pathways
12.11 PMS2 MUTYH MSH6 MSH2 MLH1
5 11.85 MSH6 MSH2 MLH1
6
Show member pathways
11.76 PMS2 MUTYH MSH6 MSH2 MLH1
7 11.72 PMS2 MSH2 MLH1
8
Show member pathways
11.16 MSH2 MLH1
9
Show member pathways
11.1 MSH2 MLH1
10 11.06 MSH6 MSH2
11 10.39 PMS2 MSH6 MSH2 MLH1
12
Show member pathways
9.92 MLH1 PMS2

GO Terms for Jejunal Cancer

Cellular components related to Jejunal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.46 PMS2 MLH1
2 MutSalpha complex GO:0032301 9.26 MSH6 MSH2
3 mismatch repair complex GO:0032300 9.02 PMS2 MSH2 MLH1

Biological processes related to Jejunal Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.97 MLH1 MSH2 MSH6 MUTYH PMS2
2 determination of adult lifespan GO:0008340 9.84 MSH6 MSH2
3 negative regulation of DNA recombination GO:0045910 9.83 MSH6 MSH2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.83 MSH6 MSH2 MLH1
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.81 MSH2 MLH1
6 positive regulation of helicase activity GO:0051096 9.8 MSH6 MSH2
7 cellular response to DNA damage stimulus GO:0006974 9.8 PMS2 MUTYH MSH6 MSH2 MLH1
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.78 MSH2 MLH1
9 isotype switching GO:0045190 9.73 MSH6 MSH2 MLH1
10 maintenance of DNA repeat elements GO:0043570 9.63 MSH6 MSH2
11 somatic hypermutation of immunoglobulin genes GO:0016446 9.56 PMS2 MSH6 MSH2 MLH1
12 somatic recombination of immunoglobulin gene segments GO:0016447 9.55 MSH6 MSH2 MLH1
13 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.5 MSH2 MLH1
14 mismatch repair GO:0006298 9.32 PMS2 MUTYH MSH6 MSH2 MLH1

Molecular functions related to Jejunal Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 single-stranded DNA binding GO:0003697 9.93 PMS2 MSH2 MLH1
2 double-stranded DNA binding GO:0003690 9.89 MSH6 MSH2 CDX2
3 MutSalpha complex binding GO:0032407 9.85 PMS2 MUTYH MLH1
4 oxidized purine DNA binding GO:0032357 9.8 MSH2 MSH6 MUTYH
5 four-way junction DNA binding GO:0000400 9.78 MSH6 MSH2
6 single guanine insertion binding GO:0032142 9.73 MSH6 MSH2
7 single thymine insertion binding GO:0032143 9.71 MSH6 MSH2
8 MutLalpha complex binding GO:0032405 9.65 MSH2 MSH6 MUTYH
9 guanine/thymine mispair binding GO:0032137 9.63 MSH6 MSH2 MLH1
10 ATP-dependent DNA damage sensor activity GO:0140664 9.56 PMS2 MSH6 MSH2 MLH1
11 mismatched DNA binding GO:0030983 9.1 PMS2 MSH6 MSH2 MLH1

Sources for Jejunal Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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