MCID: JJN003
MIFTS: 34

Jejunal Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Jejunal Cancer

MalaCards integrated aliases for Jejunal Cancer:

Name: Jejunal Cancer 12 15 17
Malignant Neoplasm of Jejunum 12 70
Jejunal Neoplasms 44 70
Malignant Tumor of Jejunum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13499
ICD9CM 34 152.1
MeSH 44 D007580
SNOMED-CT 67 93846004
ICD10 32 C17.1
UMLS 70 C0022374 C0153427

Summaries for Jejunal Cancer

MalaCards based summary : Jejunal Cancer, also known as malignant neoplasm of jejunum, is related to jejunal adenocarcinoma and myh-associated polyposis. An important gene associated with Jejunal Cancer is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and DNA Damage. Affiliated tissues include small intestine and colon, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Jejunal Cancer

Diseases related to Jejunal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)
# Related Disease Score Top Affiliating Genes
1 jejunal adenocarcinoma 30.2 PMS2 MUTYH MSH6 MLH1 KRT7 KRT20
2 myh-associated polyposis 29.5 MUTYH MSH2
3 ascending colon cancer 29.5 MSH2 MLH1 CDX2
4 familial adenomatous polyposis 29.4 MUTYH MSH6 MSH2 MLH1
5 colorectal adenoma 29.3 MUTYH MSH2 MLH1
6 adenocarcinoma 28.4 MSH6 MSH2 MLH1 KRT7 KRT20 CDX2
7 adenoma 28.2 MUTYH MSH6 MSH2 MLH1 KRT7 KRT20
8 lynch syndrome 28.1 PMS2 MUTYH MSH6 MSH2 MLH1 BMPR1A
9 spindle cell intraocular melanoma 10.3 PMS2 MLH1
10 ovary neuroendocrine neoplasm 10.3 KRT7 CDX2
11 anal canal paget's disease 10.3 KRT7 CDX2
12 anal paget's disease 10.3 KRT7 CDX2
13 gastric signet ring cell adenocarcinoma 10.3 KRT7 CDX2
14 anal gland adenocarcinoma 10.3 KRT7 CDX2
15 ureter adenocarcinoma 10.3 KRT7 CDX2
16 anus adenocarcinoma 10.3 KRT7 CDX2
17 mucinous adenofibroma 10.3 KRT7 CDX2
18 pancreatic foamy gland adenocarcinoma 10.3 KRT7 CDX2
19 bartholin's gland disease 10.3 KRT7 CDX2
20 bartholin's gland carcinoma 10.3 KRT7 CDX2
21 mucinous intrahepatic cholangiocarcinoma 10.2 KRT7 CDX2
22 ovarian seromucinous carcinoma 10.2 KRT7 CDX2
23 rectum neuroendocrine neoplasm 10.2 KRT7 CDX2
24 appendiceal neoplasm 10.2 KRT7 CDX2
25 colorectal cancer, hereditary nonpolyposis, type 4 10.2 PMS2 MLH1
26 mucinous stomach adenocarcinoma 10.2 KRT7 CDX2
27 esophageal adenosquamous carcinoma 10.2 KRT7 CDX2
28 nasal cavity olfactory neuroblastoma 10.2 KRT7 CDX2
29 epididymis adenocarcinoma 10.2 KRT7 CDX2
30 epididymis cancer 10.2 KRT7 CDX2
31 meckel diverticulum 10.2 KRT7 CDX2
32 periampullary adenoma 10.2 PMS2 MSH6
33 thymus adenocarcinoma 10.2 KRT20 CDX2
34 nasal cavity adenocarcinoma 10.2 KRT7 CDX2
35 bartholin's gland adenocarcinoma 10.2 KRT7 CDX2
36 adenomyoma 10.2 MLH1 KRT7
37 bile duct adenoma 10.2 KRT7 KRT20
38 nasal cavity cancer 10.2 KRT7 CDX2
39 esophageal tuberculosis 10.2 PMS2 MSH6
40 monophasic synovial sarcoma 10.2 MLH1 KRT7
41 clear cell adenocarcinoma 10.2 KRT7 KRT20
42 endometrioid ovary carcinoma 10.2 MSH6 MLH1
43 urethral villous adenoma 10.2 KRT7 KRT20
44 fallopian tube endometrioid adenocarcinoma 10.1 PMS2 MSH6
45 gastrointestinal adenoma 10.1 PMS2 MUTYH
46 bladder benign neoplasm 10.1 KRT7 KRT20
47 renal pelvis carcinoma 10.1 MSH6 KRT7
48 nephrogenic adenoma of urinary bladder 10.1 KRT7 KRT20
49 atrophic vulva 10.1 KRT7 KRT20
50 pancreatic serous cystadenocarcinoma 10.1 KRT7 KRT20

Comorbidity relations with Jejunal Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Intestinal Obstruction

Graphical network of the top 20 diseases related to Jejunal Cancer:



Diseases related to Jejunal Cancer

Symptoms & Phenotypes for Jejunal Cancer

GenomeRNAi Phenotypes related to Jejunal Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 MLH1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 MLH1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.17 MLH1 MSH2 MSH6 MUTYH PMS2

MGI Mouse Phenotypes related to Jejunal Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 BMPR1A CDX2 KRT7 MLH1 MSH2 MSH6
2 homeostasis/metabolism MP:0005376 9.56 BMPR1A CDX2 KRT7 MLH1 MSH2 MSH6
3 digestive/alimentary MP:0005381 9.55 BMPR1A CDX2 MLH1 MSH2 PMS2
4 neoplasm MP:0002006 9.17 BMPR1A CDX2 MLH1 MSH2 MSH6 MUTYH

Drugs & Therapeutics for Jejunal Cancer

Search Clinical Trials , NIH Clinical Center for Jejunal Cancer

Cochrane evidence based reviews: jejunal neoplasms

Genetic Tests for Jejunal Cancer

Anatomical Context for Jejunal Cancer

MalaCards organs/tissues related to Jejunal Cancer:

40
Small Intestine, Colon

Publications for Jejunal Cancer

Articles related to Jejunal Cancer:

(show all 39)
# Title Authors PMID Year
1
Minimally invasive surgery with adenocarcinoma of jejunum diagnosed pathologically before surgery: A case report. 61
33508617 2021
2
Double-balloon endoscopy facilitates efficient endoscopic resection of duodenal and jejunal polyps in patients with familial adenomatous polyposis. 61
32464675 2020
3
A sequentially metastatic gastric and jejunal cancer originating from colon cancer: A case report. 61
32470913 2020
4
Laparoscopic duodenojejunostomy requiring a side-to-side jejunojejunostomy in malignant stenosis of the gastrojejunal anastomosis in jejunal cancer: A case report. 61
32846278 2020
5
Late metastatic colon cancer masquerading as primary jejunal carcinoma. 61
26890851 2016
6
PIK3CA mutations in small bowel adenocarcinoma. 61
25908046 2015
7
[A case of primary micropapillary carcinoma of the jejunum]. 61
25759227 2015
8
[A case of Lynch syndrome with advanced jejunal cancer]. 61
25373375 2014
9
[A case of an elderly patient who underwent single-incision laparoscopic surgery for small intestine cancer]. 61
25731551 2014
10
Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview. 61
25018888 2014
11
[A case of jejnal cancer who was controlled peritoneal metastasis, successfully by combination therapy with docetaxel and S-1]. 61
24393899 2013
12
Successful treatment of primary jejunal cancer after esophageal and colon cancer resection. 61
24620639 2013
13
[A case of cancer in the dilated jejunal pouch after total gastrectomy]. 61
24393901 2013
14
[A case of small intestinal cancer with peritoneal metastases treated with FOLFOX regimen]. 61
22902454 2012
15
Response to jejunal cancer in patients with familial adenomatous polyposis. 61
21182984 2011
16
Jejunal cancer detected after a resection of bilateral ovarian metastasis: report of a case. 61
21046510 2010
17
Jejunal cancer in patients with familial adenomatous polyposis. 61
20621624 2010
18
Metastatic Small Intestinal Cancer of the Urinary Bladder. 61
21060770 2010
19
Jejunal cancer in patients with familial adenomatous polyposis. 61
20399906 2010
20
[A case of locally invasive obstructive jejunal cancer with curative resection after stenting and chemotherapy]. 61
20664318 2010
21
Double primary adenocarcinomas of the jejunum and descending colon with lung metastases presenting rare immunohistochemical phenotypes: a case report. 61
19923997 2010
22
Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case. 61
19404084 2009
23
A case of primary jejunal cancer diagnosed by preoperative small intestinal endoscopy. 61
21318964 2008
24
Education and imaging. Gastrointestinal: metallic stent for an obstructing jejunal cancer. 61
17074030 2006
25
Primary jejunal cancer. 61
16246696 2005
26
Huge ovarian metastasis from jejunal cancer occurring immediately after initial operation. 61
15816449 2005
27
[Case with double primary cancers occurring synchronously in both the lung and jejunum diagnosed according to TTF-1 expression]. 61
15770938 2005
28
[Multiple jejunal cancer diagnosed as a consequence of severe anemia]. 61
14968589 2004
29
Stereotactic radiosurgery for brain metastases from gastrointestinal tract cancer. 61
14670663 2003
30
The diagnosis and treatment of adult intussusception. 61
12488701 2003
31
Primary jejunal adenocarcinoma masquerading as a primary ovarian malignancy. 61
7789880 1995
32
Taxol and platinum chemotherapy in the treatment of pancreatic and jejunal carcinoma. 61
7609530 1995
33
Two sisters with coeliac disease and jejunal cancer: just a coincidence? 61
8446219 1993
34
[Case of jejunal cancer]. 61
5692020 1968
35
[4 Cases of jejunal cancer]. 61
13598323 1958
36
[Fistulized jejunal cancer in the transverse colon]. 61
13408674 1956
37
[Clinically silent jejunal cancer detected by radiography without preparation]. 61
13315832 1956
38
[Generalized pulmonary carcinomatosis secondary to jejunal cancer]. 61
14935836 1952
39
Jejunal cancer; a case report. 61
20992565 1946

Variations for Jejunal Cancer

Expression for Jejunal Cancer

Search GEO for disease gene expression data for Jejunal Cancer.

Pathways for Jejunal Cancer

Pathways related to Jejunal Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 PMS2 MUTYH MSH6 MSH2 MLH1
2 12.03 MUTYH MSH6 MSH2 MLH1
3 11.83 MSH6 MSH2 MLH1
4 11.77 MSH6 MSH2 BMPR1A
5 11.66 PMS2 MSH2 MLH1
6
Show member pathways
11.23 PMS2 MSH6 MSH2 MLH1
7 11.2 MSH6 MSH2 MLH1
8 11.16 MSH6 MSH2
9
Show member pathways
11.12 MSH2 MLH1
10
Show member pathways
11.06 MSH2 MLH1
11 10.39 PMS2 MSH6 MSH2 MLH1

GO Terms for Jejunal Cancer

Cellular components related to Jejunal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 condensed nuclear chromosome GO:0000794 9.26 MLH1 CDX2
2 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
3 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
4 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Jejunal Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 PMS2 MUTYH MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.72 PMS2 MUTYH MSH6 MSH2 MLH1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 MSH6 MSH2 MLH1
4 determination of adult lifespan GO:0008340 9.54 MSH6 MSH2
5 negative regulation of DNA recombination GO:0045910 9.52 MSH6 MSH2
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 MSH2 MLH1
7 positive regulation of helicase activity GO:0051096 9.49 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MSH2 MLH1
9 maintenance of DNA repeat elements GO:0043570 9.46 MSH6 MSH2
10 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
11 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MSH2 MLH1
12 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
13 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 PMS2 MSH6 MSH2 MLH1
14 mismatch repair GO:0006298 9.02 PMS2 MUTYH MSH6 MSH2 MLH1

Molecular functions related to Jejunal Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.91 PMS2 MSH6 MSH2 MLH1 BMPR1A
2 ATPase activity GO:0016887 9.73 PMS2 MSH6 MSH2 MLH1
3 double-stranded DNA binding GO:0003690 9.65 MSH6 MSH2 CDX2
4 single-stranded DNA binding GO:0003697 9.63 PMS2 MSH2 MLH1
5 ADP binding GO:0043531 9.54 MSH6 MSH2
6 DNA-dependent ATPase activity GO:0008094 9.52 MSH6 MSH2
7 MutSalpha complex binding GO:0032407 9.5 PMS2 MUTYH MLH1
8 four-way junction DNA binding GO:0000400 9.49 MSH6 MSH2
9 MutLalpha complex binding GO:0032405 9.43 MUTYH MSH6 MSH2
10 single guanine insertion binding GO:0032142 9.4 MSH6 MSH2
11 single thymine insertion binding GO:0032143 9.37 MSH6 MSH2
12 oxidized purine DNA binding GO:0032357 9.33 MUTYH MSH6 MSH2
13 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
14 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Jejunal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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