Aliases & Classifications for Jejunoileitis

MalaCards integrated aliases for Jejunoileitis:

Name: Jejunoileitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060188
ICD10 33 K50.0

Summaries for Jejunoileitis

Disease Ontology : 12 An inflammatory bowel disease that is characterized by patchy areas of inflammation located in jejunum, has symptom abdominal pain, has symptom diarrhea, has symptom cramps and has symptom formation of fistulas.

MalaCards based summary : Jejunoileitis is related to celiac disease 1 and diarrhea, and has symptoms including abdominal pain, diarrhea and cramps. An important gene associated with Jejunoileitis is PCYT1A (Phosphate Cytidylyltransferase 1, Choline, Alpha), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Immune response IL-23 signaling pathway. Affiliated tissues include jejunum, small intestine and colon, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Jejunoileitis

Diseases related to Jejunoileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 celiac disease 1 29.4 CD40LG CD79A TNF
2 diarrhea 29.4 CD40LG CD79A TNF
3 duodenitis 29.2 ATP12A ATP4A CD79A
4 jejunal atresia 11.1
5 atresia of small intestine 10.9
6 null-cell leukemia 10.7 ALDH7A1 TNF
7 systemic onset juvenile idiopathic arthritis 10.7 IL1B TNF
8 staphylococcal toxic shock syndrome 10.7 IL1B TNF
9 autoimmune myocarditis 10.7 IL1B TNF
10 kashin-beck disease 10.6 IL1B TNF
11 chronic follicular conjunctivitis 10.6 CD79A IL1B
12 vulvar vestibulitis syndrome 10.6 IL1B TNF
13 neuroschistosomiasis 10.5 CD79A NGF
14 burns 10.5 IL1B TNF
15 farmer's lung 10.5 CD79A TNF
16 selective igg deficiency disease 10.5 CD40LG CD79A
17 c1q nephropathy 10.5 CD40LG CD79A
18 spinal cord injury 10.5 GDNF NOS1 TNF
19 meningovascular neurosyphilis 10.5 CD40LG CD79A
20 alpha chain disease 10.5 CD40LG CD79A
21 brill-zinsser disease 10.5 CD40LG CD79A
22 exudative glomerulonephritis 10.5 CD40LG CD79A
23 cork-handlers' disease 10.5 CD40LG CD79A
24 salpingo-oophoritis 10.5 CD40LG CD79A
25 trench fever 10.5 CD40LG TNF
26 early yaws 10.5 CD40LG CD79A
27 encephalitozoonosis 10.5 CD40LG TNF
28 ventilation pneumonitis 10.5 CD40LG CD79A
29 chronic interstitial cystitis 10.5 CD40LG CD79A
30 axillary adenitis 10.5 CD40LG CD79A
31 rheumatoid lung disease 10.4 CD40LG TNF
32 cryofibrinogenemia 10.4 CD40LG CD79A
33 miller fisher syndrome 10.4 CD40LG TNF
34 trichostrongyloidiasis 10.4 CD40LG CD79A
35 acute vascular insufficiency of intestine 10.4 GDNF IL1B TNF
36 subacute bacterial endocarditis 10.4 CD40LG CD79A
37 heterophyiasis 10.4 CD40LG CD79A
38 immunoglobulin g deficiency 10.4 CD40LG CD79A
39 orbital granuloma 10.4 CD40LG CD79A
40 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
41 hyperglobulinemic purpura 10.4 CD40LG CD79A
42 gastroduodenitis 10.4 CD40LG CD79A
43 bacterial conjunctivitis 10.4 CD40LG CD79A
44 heavy chain disease 10.4 CD40LG CD79A
45 ophthalmia neonatorum 10.4 CD40LG CD79A
46 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
47 parotid disease 10.4 CD40LG CD79A
48 cerebral arteritis 10.4 CD40LG CD79A
49 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
50 geniculate herpes zoster 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Jejunoileitis:



Diseases related to Jejunoileitis

Symptoms & Phenotypes for Jejunoileitis

Symptoms:

12
  • abdominal pain
  • diarrhea
  • cramps
  • formation of fistulas

MGI Mouse Phenotypes related to Jejunoileitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 PCYT1A TNF NOS1 NOS3 CD40LG IL1B
2 homeostasis/metabolism MP:0005376 10.11 PCYT1A TNF NOS1 NOS3 CD40LG IL1B
3 hematopoietic system MP:0005397 10.1 PCYT1A TNF NOS1 NOS3 CD40LG IL1B
4 immune system MP:0005387 10.06 PCYT1A TNF NOS3 CD40LG GFRA1 IL1B
5 digestive/alimentary MP:0005381 10.03 TNF NOS1 NOS3 GFRA1 ELP1 ATP12A
6 mortality/aging MP:0010768 10 NOS3 PCYT1A TNF NOS1 GFRA1 CD40LG
7 muscle MP:0005369 9.7 NOS3 TNF NOS1 GFRA1 NGF ELP1
8 nervous system MP:0003631 9.65 TNF NOS1 NOS3 CD40LG GFRA1 IL1B
9 renal/urinary system MP:0005367 9.23 NOS3 CD40LG GFRA1 CD79A ELP1 NOS1

Drugs & Therapeutics for Jejunoileitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison Between Axial- and Lateral-viewing Capsule Endoscopy in Celiac Disease Recruiting NCT03095573 Not Applicable

Search NIH Clinical Center for Jejunoileitis

Genetic Tests for Jejunoileitis

Anatomical Context for Jejunoileitis

The Foundational Model of Anatomy Ontology organs/tissues related to Jejunoileitis:

19
Jejunum

MalaCards organs/tissues related to Jejunoileitis:

41
Small Intestine, Colon, T Cells, Liver

Publications for Jejunoileitis

Articles related to Jejunoileitis:

(show top 50) (show all 78)
# Title Authors Year
1
Cystic meconium peritonitis with jejunoileal atresia: Is it associated with unfavorable outcome? ( 28224094 )
2017
2
Colon adenocarcinoma after jejunoileal bypass for morbid obesity. ( 29230281 )
2017
3
Jejunoileitis in Adult-onset Familial Mediterranean Fever in Japan. ( 27150888 )
2016
4
Usefulness of Small Intestinal Endoscopy in a Case of Adult-onset Familial Mediterranean Fever Associated with Jejunoileitis. ( 26027984 )
2015
5
Clinical significance of jejunoileal involvement of non-Hodgkin's lymphoma detected by double-balloon enteroscopy. ( 23378170 )
2013
6
Postoperative infliximab and elemental diet combination in a case with diffuse, extensive jejunoileal Crohn's disease. ( 24150229 )
2013
7
Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis. ( 23049226 )
2012
8
Magnetic resonance enterography guiding treatment in children with Crohn's jejunoileitis. ( 22251165 )
2012
9
Risk factors for disease progression in advanced jejunoileal neuroendocrine tumors. ( 22205326 )
2012
10
Sleeve gastrectomy plus side-to-side jejunoileal anastomosis for the treatment of morbid obesity and metabolic diseases: a promising operation. ( 22527590 )
2012
11
Acrodermatitis due to zinc deficiency after combined vertical gastroplasty with jejunoileal bypass: case report. ( 23174873 )
2012
12
Gastrointestinal stromal tumor: a very rare cause of jejunoileal intussusception in a 6-year-old girl. ( 22595603 )
2012
13
Balloon dilatation of postoperative small bowel anastomotic stricture in an infant with apple peel intestinal atresia after serial transverse enteroplasty and jejunoileal anastomosis. ( 21129527 )
2010
14
Chronic Non-granulomatous ulcerative jejunoileitis assessed by wireless capsule endoscopy. ( 21173563 )
2010
15
TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. ( 19802525 )
2010
16
Should we be concerned about jejunoileal atresia during repair of duodenal atresia? ( 20701544 )
2010
17
Multiple jejunoileal perforations because of intestinal involvement of miliary tuberculosis in an infant. ( 18778982 )
2008
18
Multiple jejunoileal atresia and colonic atresia managed by multiple primary anastomosis with a single gastroperineal transanastomotic tube without stomas. ( 18970921 )
2008
19
Ulcerative jejunoileitis: a complication of celiac sprue simulating Crohn's disease diagnosed with capsule endoscopy (PillCam). ( 17268829 )
2007
20
Simultaneous diagnosis of ulcerative jejunoileitis and coeliac disease in an elderly man. ( 16493197 )
2006
21
Ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma. ( 16292096 )
2005
22
Crohn's jejunoileitis: the pediatrician's perspective on diagnosis and management. ( 15973125 )
2005
23
A case of ulcerative jejunoileitis treated with anti tumor necrosis factor-alpha antibodies. ( 16489326 )
2005
24
Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets. ( 15291402 )
2004
25
M2A wireless capsule endoscopy for diagnosing ulcerative jejunoileitis complicating celiac disease. ( 14986229 )
2004
26
Pediatric jejunoileitis: a severe Crohn's disease phenotype that requires intensive nutritional management. ( 15475743 )
2004
27
Severe jejunoileitis after placement of a feeding jejunostomy: a series of four cases and a review of the literature. ( 12861547 )
2003
28
Jejunoileal bypass changes the duodenal cholecystokinin and somatostatin cell density. ( 12935359 )
2003
29
Nonspecific jejunoileitis. ( 11990344 )
2002
30
Strictureplasty in diffuse Crohn's jejunoileitis: safe and durable. ( 12072628 )
2002
31
A clinicopathological study of acute necrotising jejunoileitis. ( 12415384 )
2002
32
Angiographic and immunologic studies in acute necrotizing jejunoileitis. ( 12022435 )
2002
33
Non specific jejunoileitis--a report of 8 cases. ( 11676332 )
2001
34
Literature review on the clinical relationship between ulcerative jejunoileitis, coeliac disease, and enteropathy-associated T-cell. ( 10994614 )
2000
35
Jejunoileal incarceration and strangulation through a splenic defect in a mare. ( 10495909 )
1999
36
Follow up of more than 10a88years after strictureplasty for jejunoileal Crohn's disease: long-term results and predictive factors for outcome. ( 23577713 )
1999
37
Colonic volvulus and ulcerative jejunoileitis due to occult celiac sprue. ( 9587089 )
1998
38
Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity. ( 9678192 )
1998
39
Symptomatic hypocalcemia, hypomagnesemia, and hyperphosphatemia secondary to Fleet's Phospho-Soda colonoscopy preparation in a patient with a jejunoileal bypass. ( 9125662 )
1997
40
Use of azathioprine for nongranulomatous ulcerative jejunoileitis. ( 9347165 )
1997
41
Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity. ( 9152741 )
1997
42
Reduced food intake after jejunoileal bypass: a possible association with prolonged gastric emptying and altered gut hormone patterns. ( 9209165 )
1997
43
Intestinal Microflora Settlement in Patients with Jejunoileal Bypass for Morbid Obesity. ( 10757926 )
1993
44
Truncated and native insulinlike growth factor I enhance mucosal adaptation after jejunoileal resection. ( 1375179 )
1992
45
A comparative immunohistochemical study of jejunoileal and appendiceal carcinoids. Implications for histogenesis and pathogenesis. ( 1381269 )
1992
46
Jejunoileal alveolar rhabdomyosarcoma. A case report. ( 1342201 )
1992
47
Myelofibrosis with bleeding jejunoileal angiodysplasia diagnosed by intraoperative endoscopy. ( 1946136 )
1991
48
Optic atrophy following jejunoileal bypass. ( 3156895 )
1985
49
Night blindness after jejunoileal bypass surgery. ( 3874540 )
1985
50
Colonic pseudo-obstruction: a late complication of jejunoileal bypass. ( 6547930 )
1984

Variations for Jejunoileitis

Expression for Jejunoileitis

Search GEO for disease gene expression data for Jejunoileitis.

Pathways for Jejunoileitis

Pathways related to Jejunoileitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 CD40LG CD79A NGF NOS3 TNF
2
Show member pathways
12.36 IL1B NOS1 NOS3 TNF
3 12.33 CD40LG CD79A IL1B TNF
4
Show member pathways
11.99 CD40LG IL1B NGF TNF
5 11.88 IL1B NOS3 TNF
6 11.65 IL1B NOS3 TNF
7 11.61 CD40LG IL1B TNF
8
Show member pathways
11.44 CD40LG NGF TNF
9
Show member pathways
11.34 CD40LG IL1B TNF
10
Show member pathways
11.25 ALDH7A1 NOS1 NOS3
11 11.12 CD40LG IL1B TNF
12 11 GDNF IL1B NOS1 TNF
13
Show member pathways
10.77 IL1B NOS1 TNF
14 10.74 IL1B TNF
15 10.61 NOS1 NOS3
16 10.34 NOS1 NOS3

GO Terms for Jejunoileitis

Cellular components related to Jejunoileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD40LG CD79A GFRA1 TNF

Biological processes related to Jejunoileitis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 CD40LG IL1B TNF
2 MAPK cascade GO:0000165 9.81 GDNF GFRA1 IL1B TNF
3 regulation of signaling receptor activity GO:0010469 9.72 CD40LG GDNF IL1B NGF TNF
4 vasodilation GO:0042311 9.65 NOS1 NOS3
5 regulation of nitric-oxide synthase activity GO:0050999 9.64 IL1B NOS3
6 regulation of sodium ion transport GO:0002028 9.63 NOS1 NOS3
7 regulation of blood vessel size GO:0050880 9.63 NOS1 NOS3
8 positive regulation of histone acetylation GO:0035066 9.62 IL1B NOS1
9 nitric oxide mediated signal transduction GO:0007263 9.62 NOS1 NOS3
10 cellular sodium ion homeostasis GO:0006883 9.61 ATP12A ATP4A
11 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
13 cellular potassium ion homeostasis GO:0030007 9.59 ATP12A ATP4A
14 sodium ion export across plasma membrane GO:0036376 9.58 ATP12A ATP4A
15 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.58 ATP12A ATP4A
16 negative regulation of calcium ion transport GO:0051926 9.57 NOS1 NOS3
17 nitric oxide biosynthetic process GO:0006809 9.56 NOS1 NOS3
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.55 IL1B TNF
19 positive regulation of guanylate cyclase activity GO:0031284 9.54 NOS1 NOS3
20 negative regulation of potassium ion transport GO:0043267 9.52 NOS1 NOS3
21 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IL1B TNF
22 arginine catabolic process GO:0006527 9.48 NOS1 NOS3
23 negative regulation of hydrolase activity GO:0051346 9.46 NOS1 NOS3
24 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
25 positive regulation of fever generation GO:0031622 9.4 IL1B TNF
26 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
27 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
29 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.13 GDNF IL1B TNF
30 lipopolysaccharide-mediated signaling pathway GO:0031663 8.8 IL1B NOS3 TNF

Molecular functions related to Jejunoileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.46 NOS1 NOS3
2 FMN binding GO:0010181 9.43 NOS1 NOS3
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.4 ATP12A ATP4A
4 arginine binding GO:0034618 9.37 NOS1 NOS3
5 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS1 NOS3
6 cadmium ion binding GO:0046870 9.26 NOS1 NOS3
7 tetrahydrobiopterin binding GO:0034617 9.16 NOS1 NOS3
8 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
9 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS3

Sources for Jejunoileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....