MCID: JJN008
MIFTS: 40

Jejunoileitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Jejunoileitis

MalaCards integrated aliases for Jejunoileitis:

Name: Jejunoileitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060188
ICD10 33 K50.0

Summaries for Jejunoileitis

Disease Ontology : 12 An inflammatory bowel disease that is characterized by patchy areas of inflammation located in jejunum, has symptom abdominal pain, has symptom diarrhea, has symptom cramps and has symptom formation of fistulas.

MalaCards based summary : Jejunoileitis is related to crohn's colitis and peritonitis, and has symptoms including abdominal pain, diarrhea and cramps. An important gene associated with Jejunoileitis is PCYT1A (Phosphate Cytidylyltransferase 1, Choline, Alpha), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include small intestine, t cells and colon, and related phenotypes are digestive/alimentary and cardiovascular system

Related Diseases for Jejunoileitis

Diseases related to Jejunoileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 crohn's colitis 29.8 IL1B TNF
2 peritonitis 29.7 ALB IL1B TNF
3 celiac disease 1 29.3 ALB ATP12A ATP4A TNF
4 jejunal atresia 11.2
5 atresia of small intestine 11.1
6 morbid obesity 10.4
7 crohn's disease 10.2
8 null-cell leukemia 10.2 ALDH7A1 TNF
9 exudative glomerulonephritis 10.2 IL1B TNF
10 cerebral artery occlusion 10.2 GDNF TNF
11 staphylococcal toxic shock syndrome 10.2 IL1B TNF
12 kashin-beck disease 10.2 IL1B TNF
13 rheumatoid lung disease 10.2 IL1B TNF
14 vulvar vestibulitis syndrome 10.2 IL1B TNF
15 burns 10.2 IL1B TNF
16 glossitis 10.1 IL1B TNF
17 haemophilus influenzae 10.1 IL1B TNF
18 pneumatosis cystoides intestinalis 10.1
19 opisthorchiasis 10.1 IL1B TNF
20 retinitis pigmentosa 60 10.1 IL1B TNF
21 irritant dermatitis 10.1 IL1B TNF
22 vasculogenic impotence 10.1 ALDH7A1 NOS3
23 purulent labyrinthitis 10.1 IL1B NOS3
24 congenital cytomegalovirus 10.1 IL1B TNF
25 actinic prurigo 10.1 IL1B TNF
26 neuropathy, hereditary sensory and autonomic, type iii 10.1 ELP1 NGF
27 spinal cord injury 10.1 GDNF NOS1 TNF
28 osteosclerotic myeloma 10.1 IL1B TNF
29 chronic graft versus host disease 10.1 ALB TNF
30 acute vascular insufficiency of intestine 10.1 GDNF IL1B TNF
31 poems syndrome 10.1 IL1B TNF
32 hirschsprung disease 1 10.1 GDNF GFRA1 NOS1
33 periapical periodontitis 10.1 IL1B TNF
34 euthyroid sick syndrome 10.1 ALB IL1B
35 sexual disorder 10.0 ALDH7A1 NOS1 NOS3
36 impotence 10.0 ALDH7A1 NOS1 NOS3
37 lymphoma 10.0
38 intestinal atresia 10.0
39 burning mouth syndrome 10.0 NGF TNF
40 hepatic encephalopathy 10.0 ALB NOS1 TNF
41 central nervous system vasculitis 10.0 IL1B TNF
42 autonomic neuropathy 10.0 ALB ELP1 NGF
43 pleural disease 10.0 ALB IL1B TNF
44 pyelonephritis 10.0 ALB IL1B TNF
45 appendicitis 10.0 ALB IL1B TNF
46 pulmonary edema 10.0 IL1B NOS3 TNF
47 typhoid fever 10.0 ALB IL1B TNF
48 bacterial meningitis 10.0 ALB IL1B TNF
49 meningitis 10.0 ALB IL1B TNF
50 upper respiratory tract disease 10.0 ALB IL1B TNF

Graphical network of the top 20 diseases related to Jejunoileitis:



Diseases related to Jejunoileitis

Symptoms & Phenotypes for Jejunoileitis

Symptoms:

12
  • abdominal pain
  • diarrhea
  • cramps
  • formation of fistulas

MGI Mouse Phenotypes related to Jejunoileitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.09 ALB ATP12A ATP4A ELP1 GDNF GFRA1
2 cardiovascular system MP:0005385 10.06 ELP1 GDNF IL1B NGF NOS1 NOS3
3 homeostasis/metabolism MP:0005376 10.02 ALB ATP12A ATP4A ELP1 IL1B NGF
4 hematopoietic system MP:0005397 9.97 ATP4A ELP1 GDNF IL1B NOS1 NOS3
5 endocrine/exocrine gland MP:0005379 9.95 ALB ATP4A ELP1 GDNF NOS1 NOS3
6 immune system MP:0005387 9.91 ATP4A ELP1 GDNF GFRA1 IL1B NOS1
7 mortality/aging MP:0010768 9.9 ALB ATP4A ELP1 GDNF GFRA1 IL1B
8 muscle MP:0005369 9.56 ALB ELP1 GDNF GFRA1 NGF NOS1
9 renal/urinary system MP:0005367 9.17 ALB ATP12A ELP1 GDNF GFRA1 NOS1

Drugs & Therapeutics for Jejunoileitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison Between Axial- and Lateral-viewing Capsule Endoscopy in Celiac Disease Recruiting NCT03095573 Not Applicable

Search NIH Clinical Center for Jejunoileitis

Genetic Tests for Jejunoileitis

Anatomical Context for Jejunoileitis

MalaCards organs/tissues related to Jejunoileitis:

41
Small Intestine, T Cells, Colon, Heart, Lymph Node, Spinal Cord, B Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Jejunoileitis:

19
Jejunum

Publications for Jejunoileitis

Articles related to Jejunoileitis:

(show all 32)
# Title Authors Year
1
Jejunoileitis in Adult-onset Familial Mediterranean Fever in Japan. ( 27150888 )
2016
2
Usefulness of Small Intestinal Endoscopy in a Case of Adult-onset Familial Mediterranean Fever Associated with Jejunoileitis. ( 26027984 )
2015
3
Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis. ( 23049226 )
2012
4
Magnetic resonance enterography guiding treatment in children with Crohn's jejunoileitis. ( 22251165 )
2012
5
Chronic Non-granulomatous ulcerative jejunoileitis assessed by wireless capsule endoscopy. ( 21173563 )
2010
6
TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. ( 19802525 )
2010
7
Ulcerative jejunoileitis: a complication of celiac sprue simulating Crohn's disease diagnosed with capsule endoscopy (PillCam). ( 17268829 )
2007
8
Simultaneous diagnosis of ulcerative jejunoileitis and coeliac disease in an elderly man. ( 16493197 )
2006
9
Ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma. ( 16292096 )
2005
10
Crohn's jejunoileitis: the pediatrician's perspective on diagnosis and management. ( 15973125 )
2005
11
A case of ulcerative jejunoileitis treated with anti tumor necrosis factor-alpha antibodies. ( 16489326 )
2005
12
M2A wireless capsule endoscopy for diagnosing ulcerative jejunoileitis complicating celiac disease. ( 14986229 )
2004
13
Pediatric jejunoileitis: a severe Crohn's disease phenotype that requires intensive nutritional management. ( 15475743 )
2004
14
Severe jejunoileitis after placement of a feeding jejunostomy: a series of four cases and a review of the literature. ( 12861547 )
2003
15
Nonspecific jejunoileitis. ( 11990344 )
2002
16
Strictureplasty in diffuse Crohn's jejunoileitis: safe and durable. ( 12072628 )
2002
17
A clinicopathological study of acute necrotising jejunoileitis. ( 12415384 )
2002
18
Angiographic and immunologic studies in acute necrotizing jejunoileitis. ( 12022435 )
2002
19
Non specific jejunoileitis--a report of 8 cases. ( 11676332 )
2001
20
Literature review on the clinical relationship between ulcerative jejunoileitis, coeliac disease, and enteropathy-associated T-cell. ( 10994614 )
2000
21
Colonic volvulus and ulcerative jejunoileitis due to occult celiac sprue. ( 9587089 )
1998
22
Use of azathioprine for nongranulomatous ulcerative jejunoileitis. ( 9347165 )
1997
23
Diffuse jejunoileitis with vasculitic abnormalities in the mesenteric arteries: a rare manifestation of Crohn's disease. ( 8935747 )
1996
24
Diffuse jejunoileitis of Crohn's disease. ( 8244104 )
1993
25
Radiographic features in ischemic jejunoileitis: serial changes and comparison with pathologic findings. ( 1426849 )
1992
26
Acute jejunoileitis. A distinct entity? ( 1556408 )
1992
27
Strictureplasty in diffuse Crohn's jejunoileitis. ( 4017813 )
1985
28
Nongranulomatous ulcerative jejunoileitis. ( 6731417 )
1984
29
Dual immune defects in nongranulomatous ulcerative jejunoileitis with hypogammaglobulinemia. ( 302774 )
1977
30
Proceedings: A case of pseudomembranous jejunoileitis. ( 1112684 )
1975
31
Nongranulomatous ulcerative jejunoileitis with hypogammaglobulinemia. Clinical remission after treatment with -globulin. ( 4110951 )
1972
32
Chronic ulcerative jejunoileitis. ( 4327633 )
1971

Variations for Jejunoileitis

Expression for Jejunoileitis

Search GEO for disease gene expression data for Jejunoileitis.

Pathways for Jejunoileitis

GO Terms for Jejunoileitis

Biological processes related to Jejunoileitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.96 GDNF IL1B NGF TNF
2 positive regulation of gene expression GO:0010628 9.96 IL1B NGF NOS3 TNF
3 response to lipopolysaccharide GO:0032496 9.84 IL1B NOS1 NOS3
4 MAPK cascade GO:0000165 9.73 GDNF GFRA1 IL1B TNF
5 negative regulation of neurogenesis GO:0050768 9.66 IL1B TNF
6 regulation of nitric-oxide synthase activity GO:0050999 9.65 IL1B NOS3
7 vasodilation GO:0042311 9.65 NOS1 NOS3
8 positive regulation of histone acetylation GO:0035066 9.64 IL1B NOS1
9 regulation of sodium ion transport GO:0002028 9.64 NOS1 NOS3
10 nitric oxide mediated signal transduction GO:0007263 9.63 NOS1 NOS3
11 cellular sodium ion homeostasis GO:0006883 9.63 ATP12A ATP4A
12 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
13 positive regulation of glial cell proliferation GO:0060252 9.62 IL1B TNF
14 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.61 IL1B TNF
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF
16 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.6 ATP12A ATP4A
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL1B TNF
18 negative regulation of calcium ion transport GO:0051926 9.58 NOS1 NOS3
19 cellular potassium ion homeostasis GO:0030007 9.58 ATP12A ATP4A
20 nitric oxide biosynthetic process GO:0006809 9.57 NOS1 NOS3
21 sodium ion export across plasma membrane GO:0036376 9.56 ATP12A ATP4A
22 negative regulation of potassium ion transport GO:0043267 9.55 NOS1 NOS3
23 positive regulation of guanylate cyclase activity GO:0031284 9.54 NOS1 NOS3
24 response to heat GO:0009408 9.54 IL1B NOS1 NOS3
25 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IL1B TNF
26 arginine catabolic process GO:0006527 9.51 NOS1 NOS3
27 negative regulation of hydrolase activity GO:0051346 9.49 NOS1 NOS3
28 regulation of establishment of endothelial barrier GO:1903140 9.48 IL1B TNF
29 positive regulation of neuroinflammatory response GO:0150078 9.46 IL1B TNF
30 positive regulation of fever generation GO:0031622 9.4 IL1B TNF
31 chronic inflammatory response to antigenic stimulus GO:0002439 9.32 IL1B TNF
32 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
34 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.13 GDNF IL1B TNF
35 lipopolysaccharide-mediated signaling pathway GO:0031663 8.8 IL1B NOS3 TNF

Molecular functions related to Jejunoileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 FMN binding GO:0010181 9.43 NOS1 NOS3
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.4 ATP12A ATP4A
3 arginine binding GO:0034618 9.37 NOS1 NOS3
4 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS1 NOS3
5 cadmium ion binding GO:0046870 9.26 NOS1 NOS3
6 tetrahydrobiopterin binding GO:0034617 9.16 NOS1 NOS3
7 nitric-oxide synthase activity GO:0004517 8.96 NOS1 NOS3
8 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Jejunoileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....