MCID: JJN008
MIFTS: 32

Jejunoileitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Jejunoileitis

MalaCards integrated aliases for Jejunoileitis:

Name: Jejunoileitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060188
ICD10 32 K50.0

Summaries for Jejunoileitis

Disease Ontology : 12 An inflammatory bowel disease that is characterized by patchy areas of inflammation located in jejunum, has symptom abdominal pain, has symptom diarrhea, has symptom cramps and has symptom formation of fistulas.

MalaCards based summary : Jejunoileitis is related to ileitis and celiac disease 1, and has symptoms including abdominal pain, diarrhea and cramps. An important gene associated with Jejunoileitis is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are Signaling events regulated by Ret tyrosine kinase and NCAM1 interactions. Affiliated tissues include jejunum, liver and colon, and related phenotypes are cellular and hematopoietic system

Related Diseases for Jejunoileitis

Diseases related to Jejunoileitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 ileitis 30.2 XPNPEP1 TNF
2 celiac disease 1 30.0 TOR1A TNF TGM2 MYO9B
3 dermatitis herpetiformis 29.6 TNF TGM2 MYO9B
4 megacolon 29.5 GFRA1 GDNF
5 jejunal atresia 11.7
6 leptin deficiency or dysfunction 10.9
7 body mass index quantitative trait locus 11 10.7
8 body mass index quantitative trait locus 9 10.7
9 body mass index quantitative trait locus 8 10.7
10 body mass index quantitative trait locus 4 10.7
11 body mass index quantitative trait locus 10 10.7
12 body mass index quantitative trait locus 7 10.7
13 body mass index quantitative trait locus 12 10.7
14 body mass index quantitative trait locus 14 10.7
15 body mass index quantitative trait locus 18 10.7
16 body mass index quantitative trait locus 19 10.7
17 body mass index quantitative trait locus 20 10.7
18 short bowel syndrome 10.5
19 intussusception 10.4
20 intestinal obstruction 10.4
21 diarrhea 10.4
22 crohn's disease 10.4
23 intestinal atresia 10.4
24 gluten allergy 10.3 TOR1A TGM2
25 lymphocytic gastritis 10.3 TOR1A TGM2
26 tropical sprue 10.3 TOR1A TGM2
27 wheat allergy 10.3 TOR1A TGM2
28 torsion dystonia 2 10.3 TOR1A TGM2
29 volvulus of midgut 10.3
30 osteomalacia 10.3
31 immunoglobulin a deficiency 1 10.3 TOR1A TGM2
32 lymphocytic colitis 10.3 TOR1A TGM2
33 duodenitis 10.3 TOR1A TGM2
34 focal hand dystonia 10.3 TOR1A GDNF
35 liver cirrhosis 10.3
36 overgrowth syndrome 10.3
37 whipple disease 10.3 TOR1A TGM2
38 alpha chain disease 10.3 TOR1A TGM2
39 dystonia 25 10.3 TOR1A TGM2
40 giardiasis 10.3 TOR1A TGM2
41 autoimmune disease of skin and connective tissue 10.3 TOR1A TGM2
42 lactose intolerance 10.2 TOR1A TGM2
43 nephrolithiasis, calcium oxalate 10.2
44 hyperparathyroidism 10.2
45 kidney disease 10.2
46 immunoglobulin alpha deficiency 10.2 TOR1A TGM2
47 bullous skin disease 10.2 TOR1A TGM2
48 cholelithiasis 10.2
49 peritonitis 10.2
50 gastroduodenal crohn's disease 10.2 TNF TGM2

Graphical network of the top 20 diseases related to Jejunoileitis:



Diseases related to Jejunoileitis

Symptoms & Phenotypes for Jejunoileitis

Symptoms:

12
  • abdominal pain
  • diarrhea
  • cramps
  • formation of fistulas

MGI Mouse Phenotypes related to Jejunoileitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 GDNF GFRA1 MYO9B PANX1 TGM2 TNF
2 hematopoietic system MP:0005397 9.8 GDNF MYO9B PANX1 PCYT1A TGM2 TNF
3 immune system MP:0005387 9.76 GDNF GFRA1 MYO9B PANX1 PCYT1A TGM2
4 muscle MP:0005369 9.35 GDNF GFRA1 TNF TOR1A XPNPEP1
5 nervous system MP:0003631 9.17 GDNF GFRA1 PANX1 TGM2 TNF TOR1A

Drugs & Therapeutics for Jejunoileitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Randomized Comparison Between Axial- and Lateral-viewing Capsule Endoscopy Systems in Celiac Patients: a Pilot Study Unknown status NCT03095573

Search NIH Clinical Center for Jejunoileitis

Genetic Tests for Jejunoileitis

Anatomical Context for Jejunoileitis

The Foundational Model of Anatomy Ontology organs/tissues related to Jejunoileitis:

19
Jejunum

MalaCards organs/tissues related to Jejunoileitis:

40
Liver, Colon, Skin, B Cells, Small Intestine, T Cells, Bone

Publications for Jejunoileitis

Articles related to Jejunoileitis:

(show top 50) (show all 84)
# Title Authors PMID Year
1
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn's Disease-Like Inflammation. 61
31276162 2020
2
Ulcerative Jejunoileitis Presenting as Protein-Losing Enteropathy: A Diagnostic and Therapeutic Dilemma. 61
31789630 2019
3
Cryptogenic Multifocal Ulcerating Stenosing Enteropathy(CMUSE) and/or Chronic Non-specific Multiple Ulcers of the Small Intestine(CNSU) and Non-granulomatous Ulcerating Jejunoileitis (NGUJI). 61
31501950 2019
4
Celiac disease: a comprehensive current review. 61
31331324 2019
5
Intestinal fibrosis. 61
30385174 2019
6
Successful use of TNF╬▒ blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura. 61
30899536 2019
7
Role of capsule endoscopy in alarm features and non-responsive celiac disease: A European multicenter study. 61
29253321 2018
8
Clinical cystoisosporosis associated to porcine cytomegalovirus (PCMV, Suid herpesvirus 2) infection in fattening pigs. 61
28942051 2017
9
Use of enteroscopy for the detection of malignant and premalignant lesions of the small bowel in complicated celiac disease: a meta-analysis. 61
28433612 2017
10
Beyond moulage sign and TTG levels: the role of cross-sectional imaging in celiac sprue. 61
28154909 2017
11
Celiac disease: a clinical review. 61
28078381 2017
12
Collagenous sprue cross-sectional imaging: a comparative blinded study. 61
28058450 2017
13
Enteroscopy and radiology for the management of celiac disease complications: Time for a pragmatic roadmap. 61
27012449 2016
14
Refractory Celiac Disease Type II: A Case Report that Demonstrates the Diagnostic and Therapeutic Challenges. 61
28868442 2016
15
Jejunoileitis in Adult-onset Familial Mediterranean Fever in Japan. 61
27150888 2016
16
Usefulness of Small Intestinal Endoscopy in a Case of Adult-onset Familial Mediterranean Fever Associated with Jejunoileitis. 61
26027984 2015
17
Is it worth investigating splenic function in patients with celiac disease? 61
23613624 2013
18
Unknown complicated celiac disease as an unexpected finding in patients investigated with capsule endoscopy for Crohn's disease. A case series. 61
23539398 2013
19
Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis. 61
23049226 2012
20
Magnetic resonance enterography guiding treatment in children with Crohn's jejunoileitis. 61
22251165 2012
21
[Gastrointestinal bleeding and intestinal perforation due to polyarteritis nodosa in a patient with celiac disease. A case report]. 61
22292228 2011
22
Chronic Non-granulomatous ulcerative jejunoileitis assessed by wireless capsule endoscopy. 61
21173563 2010
23
TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. 61
19802525 2010
24
Chronic bilious vomiting in children in developing countries due to high bowel obstruction: not always malrotation or tuberculosis. 61
19911183 2010
25
Celiac disease as a potential cause of idiopathic portal hypertension: a case report. 61
19220902 2009
26
Capability of capsule endoscopy in detecting small bowel ulcers. 61
18536988 2009
27
Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease. 61
18550468 2008
28
[Algorithm for diagnosis of small intestinal diseases]. 61
18491580 2008
29
Cystic lymphangioma of the mesentery and hyposplenism in celiac disease. 61
18049176 2007
30
[Acute abdomen in celiac disease: ulcerative jejunoileitis]. 61
17883303 2007
31
Ulcerative jejunoileitis: a complication of celiac sprue simulating Crohn's disease diagnosed with capsule endoscopy (PillCam). 61
17268829 2007
32
Splenic hypofunction and the spectrum of autoimmune and malignant complications in celiac disease. 61
16469678 2006
33
Simultaneous diagnosis of ulcerative jejunoileitis and coeliac disease in an elderly man. 61
16493197 2006
34
A case of ulcerative jejunoileitis treated with anti tumor necrosis factor-alpha antibodies. 61
16489326 2005
35
Ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma. 61
16292096 2005
36
Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression. 61
16133968 2005
37
Crohn's jejunoileitis: the pediatrician's perspective on diagnosis and management. 61
15973125 2005
38
[Spontaneous hemoperitoneum secondary the jejunoileitis by Anisakis]. 61
15997512 2005
39
Pediatric jejunoileitis: a severe Crohn's disease phenotype that requires intensive nutritional management. 61
15475743 2004
40
M2A wireless capsule endoscopy for diagnosing ulcerative jejunoileitis complicating celiac disease. 61
14986229 2004
41
Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia. 61
14724154 2004
42
Jejunoileal Crohn's disease: a case-control study. 61
15060461 2004
43
Severe jejunoileitis after placement of a feeding jejunostomy: a series of four cases and a review of the literature. 61
12861547 2003
44
Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells. 61
12806607 2003
45
A clinicopathological study of acute necrotising jejunoileitis. 61
12415384 2002
46
Strictureplasty in diffuse Crohn's jejunoileitis: safe and durable. 61
12072628 2002
47
Angiographic and immunologic studies in acute necrotizing jejunoileitis. 61
12022435 2002
48
Ataxia in the setting of complicated enteropathy: double jeopardy. 61
11909917 2002
49
Nonspecific jejunoileitis. 61
11990344 2002
50
Coeliac disease and malignancy. 61
11990397 2002

Variations for Jejunoileitis

Expression for Jejunoileitis

Search GEO for disease gene expression data for Jejunoileitis.

Pathways for Jejunoileitis

Pathways related to Jejunoileitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 GFRA1 GDNF
2 10.19 GFRA1 GDNF
3 9.63 GFRA1 GDNF

GO Terms for Jejunoileitis

Biological processes related to Jejunoileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.43 TNF GFRA1 GDNF
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.37 TNF TGM2
3 positive regulation of cell adhesion GO:0045785 9.32 TNF TGM2
4 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.16 TNF GDNF
5 positive regulation of cytokine secretion GO:0050715 8.96 TNF PANX1
6 regulation of dopamine uptake involved in synaptic transmission GO:0051584 8.62 TOR1A GDNF

Molecular functions related to Jejunoileitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.92 XPNPEP1 PCYT1A MYO9B GDNF

Sources for Jejunoileitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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