Aliases & Classifications for Joint Disorders

MalaCards integrated aliases for Joint Disorders:

Name: Joint Disorders 38 43
Arthropathy 73

External Ids:

UMLS 73 C0022408

Summaries for Joint Disorders

MedlinePlus : 43 A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. Joints can be damaged by many types of injuries or diseases, including Arthritis - inflammation of a joint. It causes pain, stiffness, and swelling. Over time, the joint can become severely damaged. Bursitis - inflammation of a fluid-filled sac that cushions the joint Dislocations - injuries that force the ends of the bones out of position Treatment of joint problems depends on the cause. If you have a sports injury, treatment often begins with the RICE (Rest, Ice, Compression, and Elevation) method to relieve pain, reduce swelling, and speed healing. Other possible treatments include pain relievers, keeping the injured area from moving, rehabilitation, and sometimes surgery. For arthritis, injuries, or other diseases, you may need joint replacement surgery to remove the damaged joint and put in a new one. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Joint Disorders, also known as arthropathy, is related to osteoarthritis and bone resorption disease, and has symptoms including joint stiffness, arthralgia and back pain. An important gene associated with Joint Disorders is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Etanercept and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Joint Disorders

Diseases related to Joint Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 osteoarthritis 29.8 IL1B IL6 MMP3 TIMP1 TNF
2 bone resorption disease 29.7 DKK1 IL6 TNFSF11
3 arthritis 29.6 CSF1 IL17A IL1B IL1RN IL6 MMP3
4 juvenile rheumatoid arthritis 29.5 IL1B IL1R1 IL1RN IL6 TNF
5 osteomyelitis 29.3 IL1B IL1RN IL6 TNF TNFSF11
6 psoriatic arthritis 29.2 IL17A IL1B IL6 MMP3 TNF TNFSF11
7 rheumatoid arthritis 28.8 CSF1 IL11 IL17A IL1B IL1R1 IL1RN
8 osteoporosis 28.3 CSF1 DKK1 IL11 IL1B IL1RAPL2 IL1RN
9 arthropathy 10.8
10 osteochondritis dissecans 10.6
11 adenosine monophosphate deaminase 1 deficiency 10.6
12 crystal arthropathies 10.6
13 familial osteochondritis dissecans 10.6
14 exostosis 10.6
15 ankylosis 10.5
16 bunion 10.5
17 cardiogenic shock 10.3 IL6 TNF
18 periodontitis, chronic 10.2 IL1B IL6 TNFSF11
19 recurrent corneal erosion 10.2 IL1B IL6
20 bagassosis 10.2 IL1B IL6
21 langerhans cell histiocytosis 10.2 CSF1 IL17A TNFSF11
22 scorpion envenomation 10.2 IL6 TNF
23 osteopetrosis, autosomal recessive 7 10.2 CSF1 TNFSF11
24 radiculopathy 10.2 IL17A IL1R1 IL6
25 paraneoplastic syndromes 10.2 IL1B IL6
26 preterm premature rupture of the membranes 10.2 IL1B IL6 IL6R
27 plasmacytoma 10.2 IL11 IL6 IL6R
28 multicentric reticulohistiocytosis 10.2 CSF1 TNFSF11
29 patella, chondromalacia of 10.2
30 bruck syndrome 10.2
31 hemarthrosis 10.2
32 cryopyrin-associated periodic syndrome 10.2 IL1R1 IL1RN IL6
33 kummell's disease 10.2 DKK1 TNFSF11
34 exudative glomerulonephritis 10.2 IL1B TNF
35 root resorption 10.2 IL1B IL1RN TNFSF11
36 leukomalacia 10.2 IL6 TNF
37 myelitis 10.2 IL17A IL6 TNF
38 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
39 bronchiolitis 10.2 IL17A IL6 TNF
40 monoclonal gammopathy of uncertain significance 10.2 DKK1 IL6 TNF
41 schnitzler syndrome 10.2 IL1B IL1R1 IL1RN
42 meningitis 10.2 IL1B IL6 TNF
43 autoimmune disease of eyes, ear, nose and throat 10.2 IL17A IL6 TNF
44 transverse myelitis 10.2 IL17A IL6 TNF
45 mycoplasma pneumoniae pneumonia 10.2 IL17A IL6 TNF
46 stromal keratitis 10.2 IL17A IL6 TNF
47 cinca syndrome 10.1 IL1B IL1R1 IL1RN
48 glossitis 10.1 IL1B IL6 TNF
49 laryngitis 10.1 IL1B IL6 TNF
50 acute vascular insufficiency of intestine 10.1 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Joint Disorders:



Diseases related to Joint Disorders

Symptoms & Phenotypes for Joint Disorders

UMLS symptoms related to Joint Disorders:


joint stiffness, arthralgia, back pain, sciatica, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

GenomeRNAi Phenotypes related to Joint Disorders according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.55 CSF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.55 CSF1 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.55 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.55 IL1RN
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.55 TNFSF11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.55 CSF1 IL18R1 IL1RN PLAU TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.55 PLAU
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.55 IL18R1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.55 PLAU
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.55 CSF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.55 CSF1 TNFSF11

MGI Mouse Phenotypes related to Joint Disorders:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 CSF1 IL17A IL18R1 IL1B IL1R1 IL1RN
2 homeostasis/metabolism MP:0005376 10.31 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
3 growth/size/body region MP:0005378 10.29 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
4 immune system MP:0005387 10.28 CSF1 IL17A IL18R1 IL1B IL1R1 IL1RN
5 endocrine/exocrine gland MP:0005379 10.19 CSF1 IL17A IL1R1 IL6 IL6R PLAU
6 mortality/aging MP:0010768 10.13 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
7 craniofacial MP:0005382 10.11 CSF1 DKK1 IL17A IL1B IL1R1 PLAU
8 integument MP:0010771 9.97 CSF1 IL1B IL1R1 IL1RN IL6 PLAU
9 muscle MP:0005369 9.86 CSF1 IL1R1 IL6 PLAU RARRES2 SERPINB2
10 neoplasm MP:0002006 9.81 IL1B IL1R1 IL6 IL6R PLAU SERPINB2
11 respiratory system MP:0005388 9.61 CSF1 DKK1 IL17A IL1R1 IL6 PLAU
12 skeleton MP:0005390 9.4 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN

Drugs & Therapeutics for Joint Disorders

Drugs for Joint Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 963)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 185243-69-0
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
3
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
5
Thrombin Approved, Investigational Phase 4,Not Applicable
6
Bevacizumab Approved, Investigational Phase 4 216974-75-3
7
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 124-94-7 31307
8
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
9
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
10
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
11
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
12
Dalteparin Approved Phase 4,Phase 3 9005-49-6
13
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
14
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3416-24-8 439213
15
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
17
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
18
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
19
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 378-44-9 9782
20
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 66635-83-4, 74103-06-3 3826
21
Iron Approved Phase 4,Phase 1,Phase 2,Not Applicable 7439-89-6 23925
22
Rivaroxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 366789-02-8
23
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 1302 156391
24
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
25
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
26
Chitosan Approved Phase 4,Phase 3,Not Applicable 9012-76-4 71853
27
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
28
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
29
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
30
Hyoscyamine Approved Phase 4,Not Applicable 101-31-5 64692
31
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
32
Norepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-41-2 439260
33
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
34
Tacrolimus Approved, Investigational Phase 4,Phase 3 104987-11-3 445643 439492
35
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-05-2, 1959-05-2 126941
36
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 332348-12-6 10237
37
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
38
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 599-79-1 5353980 5359476
39
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Not Applicable 118-42-3 3652
40
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
41
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
42
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
43
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 15307-86-5 3033
44
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 202409-33-4 123619
45
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 174722-31-7 10201696
46
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0
47
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
48
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2921-57-5
49
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 16590-41-3 5360515
50
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 7525)
# Name Status NCT ID Phase Drugs
1 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
2 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
3 A Clinical Phenotype Based Individualized Prophylaxis in Chinese Hemophilia A Children Unknown status NCT02999308 Phase 4
4 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
5 The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis Unknown status NCT00808496 Phase 4
6 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
7 Birmingham Hip Resurfacing (BHR) Study: Implantation of a Hip Resurfacing Endoprosthesis Unknown status NCT00180206 Phase 4
8 W-Shaped Acetabular Angular Plate (WAAP) Versus Reconstruction Plate Unknown status NCT02327949 Phase 4
9 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4 Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
10 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4 Bevacizumab intra-articular injection
11 Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02949466 Phase 4 Triamcinolone
12 Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty Unknown status NCT02865174 Phase 4 Topical tranexamic acid;Floseal®;Enoxaparin
13 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
14 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
15 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
16 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
17 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
18 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
19 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
20 26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle Unknown status NCT02627859 Phase 4
21 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
22 Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
23 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
24 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
25 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
26 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
27 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
28 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
29 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
30 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
31 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
32 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
33 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
34 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
35 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
36 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
37 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
38 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
39 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
40 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
41 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
42 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
43 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
44 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
45 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
46 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
47 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
48 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
49 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
50 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4

Search NIH Clinical Center for Joint Disorders

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Joint Disorders cell therapies at LifeMap Discovery.

Genetic Tests for Joint Disorders

Anatomical Context for Joint Disorders

MalaCards organs/tissues related to Joint Disorders:

41
Bone, Skin, Testes, Lung, Monocytes, Lymph Node, Eye

Publications for Joint Disorders

Articles related to Joint Disorders:

(show top 50) (show all 735)
# Title Authors Year
1
Clinical Applications of Positron Emission Tomography in the Evaluation of Spine and Joint Disorders. ( 30420222 )
2019
2
Platelet-rich plasma for the therapeutic management of temporomandibular joint disorders: a systematic review. ( 29066000 )
2018
3
Assessment of MRI findings and clinical symptoms in patients with temporomandibular joint disorders. ( 29451403 )
2018
4
Single puncture versus standard double needle arthrocentesis for the management of temporomandibular joint disorders: A systematic review. ( 29889989 )
2018
5
Mechanical perturbation model of temporomandibular joint disorders and assessment of musculature. ( 29578945 )
2018
6
The Use of Synovial Fluid Analysis for Diagnosis of Temporomandibular Joint Disorders. ( 29861340 )
2018
7
Prevalence of tinnitus according to temporomandibular joint disorders and dental pain: The Korean National Population-based Study. ( 29314140 )
2018
8
Pediatric Temporomandibular Joint Disorders. ( 29046237 )
2018
9
Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders. ( 29331039 )
2018
10
Prevalence, Nature, and Management of Oral Stage Dysphagia in Adults With Temporomandibular Joint Disorders: Findings From an Irish Cohort. ( 29549021 )
2018
11
Evaluation of Pain Syndromes, Headache, and Temporomandibular Joint Disorders in Children. ( 29153234 )
2018
12
Management of temporomandibular joint disorders: A surgeon's perspective. ( 29574810 )
2018
13
Evaluation of a Patient With Temporomandibular Joint Disorders in Paget's Disease of Bone. ( 29361426 )
2018
14
Nonhemorrhagic joint disorders and vitamin K antagonists: an under-recognized adverse drug reaction? ( 29729202 )
2018
15
Modified SauvAc-Kapandji procedure for the distal radioulnar joint disorders of osteoarthritis and rheumatoid arthritis. ( 29551357 )
2018
16
Analysis of synovial fluid visfatin level in temporomandibular joint disorders. ( 29385907 )
2018
17
Current Concepts in the Management of Proximal Interphalangeal Joint Disorders. ( 29625647 )
2018
18
Intra-articular biomaterials-assisted delivery to treat temporomandibular joint disorders. ( 29785258 )
2018
19
Temporomandibular Joint Disorders in Older Adults. ( 29719041 )
2018
20
Temporomandibular joint disorders as the only manifestation of juvenile idiopathic arthritis: a case report. ( 30208154 )
2018
21
Arthropathy-like findings and a carpal tunnel syndrome as the presenting features of Scheie syndrome: Three cases from the same family. ( 30511553 )
2018
22
Knee Arthroscopy: A Diagnostic and Therapeutic Tool for Management of Ochronotic Arthropathy. ( 30533354 )
2018
23
Clinical Features and Treatment of Down Syndrome Arthropathy: Experience from Two US Tertiary Hospitals. ( 30547384 )
2018
24
Jaccoud's Arthropathy and Jaundice in a Young Female. ( 30557734 )
2018
25
Heel pain in psoriatic arthropathy: Analysis of a series of 291 patients. ( 28576643 )
2018
26
Health-Related Quality of Life and Association With Arthropathy in Greek Patients with Hemophilia. ( 28992766 )
2018
27
Hybrid Fixation for Ankle Fusion in Diabetic Charcot Arthropathy. ( 29035584 )
2018
28
Angiographic assessment of atherosclerotic load at the lower extremity in patients with diabetic foot and charcot neuro-arthropathy. ( 29056486 )
2018
29
Response to: missing angiogenic factors in hemophilic arthropathy. ( 29092644 )
2018
30
MRI ankle and subtalar characteristics in haemochromatosis arthropathy: a case-control study. ( 29126545 )
2018
31
Treating Charcot Arthropathy Is a Challenge: Explaining Why My Treatment Algorithm Has Changed. ( 29156160 )
2018
32
Intra-articular corticosteroid injections in haemophilic arthropathy: are they recommended? ( 29172843 )
2018
33
Mid-term outcomes and complications of total knee arthroplasty in haemophilic arthropathy: A review of consecutive 131 knees between 2006 and 2015 in a single institute. ( 29193440 )
2018
34
Crystalline arthropathy and bone health. ( 29194109 )
2018
35
Characteristics of children with acute lymphoblastic leukemia presenting with arthropathy. ( 29464526 )
2018
36
Injury to the axillary and suprascapular nerves in rotator cuff arthropathy and after reverse shoulder arthroplasty: a prospective electromyographic analysis. ( 29475786 )
2018
37
Physiotherapist inter-rater reliability of the Haemophilia Early Arthropathy Detection with Ultrasound protocol. ( 29493853 )
2018
38
Beekeeper' arthropathy. ( 29530760 )
2018
39
Prevalence of Charcot Arthropathy in Type 2 Diabetes Patients Aged over 50 Years with Severe Peripheral Neuropathy: A Retrospective Study in a Tertiary Care South Indian Hospital. ( 29535947 )
2018
40
Assessment of passive musculoarticular ankle stiffness in children, adolescents and young adults with haemophilic ankle arthropathy. ( 29600577 )
2018
41
The contribution of thoracic vertebral deformity and arthropathy to trunk pain in patients with chronic obstructive pulmonary disease (COPD). ( 29605193 )
2018
42
Diabetic Neuropathic Arthropathy of the Knee: Two Case Reports and a Review of the Literature. ( 29610694 )
2018
43
Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Amyloid Arthropathy Associated to Multiple Myeloma. ( 29620592 )
2018
44
Challenge of handling a Charcot spinal arthropathy with a novel hybrid fibular autograft and expandable cage. ( 29652238 )
2018
45
Jaccoud's Arthropathy. ( 29987749 )
2018
46
Bone mineral density in type 2 diabetes patients with Charcot arthropathy. ( 29992889 )
2018
47
Charcot arthropathy of the shoulder joint as a presenting feature of basilar impression with syringomyelia: A case report and literature review. ( 29995782 )
2018
48
Clinical and radiologic results after open-wedge high tibial osteotomy in haemophilic knee arthropathy with varus deformity. ( 30004150 )
2018
49
Hemophilic arthropathy in a patient with multi-joint replacement: A case report and literature review. ( 30024499 )
2018
50
The combination of urinary CTX-II and serum CS-846: Promising biochemical markers to predict radiographic progression of haemophilic arthropathy-An exploratory study. ( 30044054 )
2018

Variations for Joint Disorders

Expression for Joint Disorders

Search GEO for disease gene expression data for Joint Disorders.

Pathways for Joint Disorders

Pathways related to Joint Disorders according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
2
Show member pathways
13.89 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
3
Show member pathways
13.71 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
4
Show member pathways
13.58 IL11 IL17A IL18R1 IL1B IL1R1 IL6
5
Show member pathways
13.4 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
6
Show member pathways
13.33 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
7
Show member pathways
13.21 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
8 12.79 CSF1 IL1B IL1R1 IL1R2 TNF
9
Show member pathways
12.77 IL1B IL1R1 IL1R2 IL6 TIMP1 TNF
10
Show member pathways
12.67 IL17A IL18R1 IL1B IL1R1 IL6 IL6R
11
Show member pathways
12.66 IL17A IL18R1 IL1B IL6 TIMP1 TNF
12 12.61 IL17A IL1B IL1RN TNF TNFSF11
13
Show member pathways
12.44 IL17A IL1B IL6 TNF
14 12.44 IL1R1 IL1R2 IL6 TNF
15
Show member pathways
12.42 IL17A IL1B IL6 IL6R MMP3 TNF
16
Show member pathways
12.36 CSF1 IL1B IL6 TNF
17
Show member pathways
12.34 IL1B IL1R1 IL1R2 IL1RN
18
Show member pathways
12.33 IL1B IL1R1 IL6 TNF
19
Show member pathways
12.31 IL17A IL1B IL6 TIMP1 TNF
20 12.29 IL1R2 IL6 MMP3 PLAU
21
Show member pathways
12.28 IL18R1 IL1B IL1R1 IL1R2 IL1RN IL6
22
Show member pathways
12.26 IL11 IL1B IL1R1 IL6 TNF
23 12.25 IL1B IL1RN IL6 IL6R TNF
24
Show member pathways
12.15 IL11 IL17A IL18R1 IL1B IL1R1 IL6
25 12.14 IL1B IL1R1 IL1R2 TNF
26 12.13 CSF1 IL1B IL1R1 TNF TNFSF11
27
Show member pathways
12.09 IL1B IL6 MMP3 TNF
28 12.07 IL1B IL1R1 IL6 TNF
29 12.07 CSF1 IL18R1 IL1B IL6 MMP3 TNF
30
Show member pathways
12.06 IL17A IL18R1 IL1B IL1R1 IL6 IL6R
31 12.05 IL1B IL6 IL6R PLAU SERPINB2
32 12.04 CSF1 IL11 IL6 TNF
33 11.99 IL1B IL1R1 IL1R2 IL6 TNF
34 11.97 IL1B IL1R1 PLAU TNF TNFSF11
35 11.97 IL17A IL1B IL6 IL6R MMP3 TIMP1
36 11.92 IL6 IL6R TIMP1
37 11.91 IL1B IL6 TNF
38
Show member pathways
11.91 MMP3 TIMP1 TNF
39
Show member pathways
11.91 IL6 IL6R TIMP1 TNFSF11
40
Show member pathways
11.88 IL17A IL6 IL6R
41 11.87 IL17A IL1B IL1R1 TNF
42 11.83 CSF1 IL1B IL6 TNF
43 11.79 IL1B IL6 TNF
44
Show member pathways
11.76 IL1B IL6 MMP3 TNF
45 11.76 IL1B IL6 PLAU TIMP1 TNF
46 11.76 IL17A IL1B IL1RN IL6 MMP3 TNF
47 11.74 CSF1 IL11 IL1B IL1R1 IL1R2 IL6
48 11.68 MMP3 PLAU TIMP1
49
Show member pathways
11.66 IL11 IL6 IL6R
50 11.63 IL1B IL6 TNF

GO Terms for Joint Disorders

Cellular components related to Joint Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CSF1 DKK1 IL11 IL17A IL1B IL1RN
2 extracellular region GO:0005576 9.55 CSF1 DKK1 IL11 IL17A IL1B IL1R1
3 interleukin-6 receptor complex GO:0005896 9.16 IL6 IL6R
4 plasma membrane GO:0005886 10.03 CSF1 DKK1 IL18R1 IL1R1 IL1R2 IL1RAPL2

Biological processes related to Joint Disorders according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 IL1B IL1RN TNF TNFSF11
2 cellular response to lipopolysaccharide GO:0071222 9.94 IL1B IL1RN IL6 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL18R1 IL1B IL6 TNF TNFSF11
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL1B IL6 TNF TNFSF11
5 immune response GO:0006955 9.91 IL17A IL18R1 IL1B IL1R1 IL1R2 IL1RN
6 defense response to Gram-positive bacterium GO:0050830 9.87 IL6 RARRES2 TNF
7 positive regulation of JNK cascade GO:0046330 9.87 IL1B IL1RN TNF TNFSF11
8 wound healing GO:0042060 9.86 IL1B SERPINB2 TIMP1
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.86 IL11 IL6 IL6R
10 defense response to Gram-negative bacterium GO:0050829 9.86 IL6 IL6R RARRES2
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 IL11 IL6 TNF
12 response to glucocorticoid GO:0051384 9.85 IL1B IL1RN IL6 TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 IL6 IL6R TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 IL18R1 IL1B TNF
15 interleukin-1-mediated signaling pathway GO:0070498 9.83 IL1B IL1R1 IL1R2 IL1RN
16 monocyte chemotaxis GO:0002548 9.81 IL6 IL6R TNFSF11
17 positive regulation of JUN kinase activity GO:0043507 9.81 DKK1 IL1B IL1RN TNF
18 inflammatory response GO:0006954 9.81 CSF1 IL17A IL18R1 IL1B IL1R1 IL1RN
19 cytokine-mediated signaling pathway GO:0019221 9.8 CSF1 IL11 IL17A IL1B IL1R1 IL1R2
20 osteoclast differentiation GO:0030316 9.79 CSF1 TNF TNFSF11
21 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
22 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL1RN IL6 IL6R TNF
23 positive regulation of chemokine production GO:0032722 9.75 IL6 IL6R TNF
24 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B IL6 TNF
25 positive regulation of interferon-gamma production GO:0032729 9.72 IL18R1 IL1B IL1R1 IL6R TNF
26 positive regulation of osteoclast differentiation GO:0045672 9.71 CSF1 IL17A TNF TNFSF11
27 interleukin-6-mediated signaling pathway GO:0070102 9.7 IL6 IL6R
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
29 regulation of osteoclast differentiation GO:0045670 9.7 TNF TNFSF11
30 positive regulation of macrophage chemotaxis GO:0010759 9.69 CSF1 RARRES2
31 positive regulation of leukocyte chemotaxis GO:0002690 9.68 IL6 IL6R
32 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
33 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B