Aliases & Classifications for Joint Disorders

MalaCards integrated aliases for Joint Disorders:

Name: Joint Disorders 39 44
Arthropathy 74

External Ids:

UMLS 74 C0022408

Summaries for Joint Disorders

MedlinePlus : 44 A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. Joints can be damaged by many types of injuries or diseases, including Arthritis - inflammation of a joint. It causes pain, stiffness, and swelling. Over time, the joint can become severely damaged. Bursitis - inflammation of a fluid-filled sac that cushions the joint Dislocations - injuries that force the ends of the bones out of position Treatment of joint problems depends on the cause. If you have a sports injury, treatment often begins with the RICE (Rest, Ice, Compression, and Elevation) method to relieve pain, reduce swelling, and speed healing. Other possible treatments include pain relievers, keeping the injured area from moving, rehabilitation, and sometimes surgery. For arthritis, injuries, or other diseases, you may need joint replacement surgery to remove the damaged joint and put in a new one. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Joint Disorders, also known as arthropathy, is related to bone resorption disease and osteoarthritis, and has symptoms including joint stiffness, arthralgia and back pain. An important gene associated with Joint Disorders is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adalimumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Joint Disorders

Diseases related to Joint Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 bone resorption disease 29.9 DKK1 IL6 TNFSF11
2 osteoarthritis 29.6 IL1B IL6 MMP3 TIMP1 TNF
3 juvenile rheumatoid arthritis 29.5 IL1B IL1R1 IL1RN IL6 TNF
4 arthritis 29.3 CSF1 IL17A IL1B IL1RN IL6 MMP3
5 osteomyelitis 29.2 IL1B IL1RN IL6 TNF TNFSF11
6 rheumatic disease 29.2 IL1B IL1R1 TNF
7 psoriatic arthritis 28.9 IL17A IL1B IL6 MMP3 TNF TNFSF11
8 osteoporosis 28.6 CSF1 DKK1 IL11 IL1B IL1RN IL6
9 rheumatoid arthritis 28.0 CSF1 IL11 IL17A IL1B IL1R1 IL1RN
10 arthropathy 10.9
11 osteochondritis dissecans 10.6
12 adenosine monophosphate deaminase 1 deficiency 10.6
13 crystal arthropathies 10.6
14 familial osteochondritis dissecans 10.6
15 exostosis 10.6
16 ankylosis 10.5
17 bunion 10.5
18 mandibular cancer 10.5 CSF1 TNFSF11
19 acute cholangitis 10.5 IL1RN IL6
20 cryopyrin-associated periodic syndrome 10.4 IL1R1 IL1RN IL6
21 osteopetrosis, autosomal recessive 7 10.4 CSF1 TNFSF11
22 multicentric reticulohistiocytosis 10.4 CSF1 TNFSF11
23 kummell's disease 10.3 DKK1 TNFSF11
24 scleral disease 10.3 IL1RN TNF
25 pustulosis of palm and sole 10.3 IL1RN TNF
26 recurrent corneal erosion 10.3 IL1B IL6
27 periodontitis, chronic 10.3 IL1B IL6 TNFSF11
28 scorpion envenomation 10.3 IL6 TNF
29 plasmacytoma 10.3 IL11 IL6 IL6R
30 radiculopathy 10.3 IL17A IL1R1 IL6
31 bagassosis 10.3 IL1B IL6
32 langerhans cell histiocytosis 10.3 CSF1 IL17A TNFSF11
33 trichosporonosis 10.3 IL17A TNF
34 root resorption 10.3 IL1B IL1RN TNFSF11
35 leukomalacia 10.2 IL6 TNF
36 schnitzler syndrome 10.2 IL1B IL1R1 IL1RN
37 patella, chondromalacia of 10.2
38 bruck syndrome 10.2
39 hemarthrosis 10.2
40 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
41 cinca syndrome 10.2 IL1B IL1R1 IL1RN
42 hydrarthrosis 10.2 IL1B IL1RN MMP3
43 preterm premature rupture of the membranes 10.2 IL1B IL6 IL6R
44 autoimmune myocarditis 10.2 IL6 TNF
45 juvenile ankylosing spondylitis 10.2 IL1RN IL6 TNF
46 monoclonal gammopathy of uncertain significance 10.2 DKK1 IL6 TNF
47 post-transplant lymphoproliferative disease 10.2 IL1R1 IL6 TNF
48 exanthem 10.2 IL1RN IL6 TNF
49 brucellosis 10.2 IL1RN IL6 TNF
50 exudative glomerulonephritis 10.2 IL1B TNF

Graphical network of the top 20 diseases related to Joint Disorders:



Diseases related to Joint Disorders

Symptoms & Phenotypes for Joint Disorders

UMLS symptoms related to Joint Disorders:


joint stiffness, arthralgia, back pain, sciatica, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

GenomeRNAi Phenotypes related to Joint Disorders according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.53 CSF1 TNFSF11
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.53 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.53 IL1RN
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.53 TNFSF11
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 CSF1 IL18R1 IL1RN PLAU TNFSF11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.53 PLAU
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.53 IL18R1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.53 PLAU
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 CSF1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 CSF1 TNFSF11

MGI Mouse Phenotypes related to Joint Disorders:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 CSF1 IL17A IL18R1 IL1B IL1R1 IL1RN
2 homeostasis/metabolism MP:0005376 10.31 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
3 growth/size/body region MP:0005378 10.29 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
4 immune system MP:0005387 10.28 CSF1 IL17A IL18R1 IL1B IL1R1 IL1RN
5 endocrine/exocrine gland MP:0005379 10.19 CSF1 IL17A IL1R1 IL6 IL6R PLAU
6 mortality/aging MP:0010768 10.13 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
7 craniofacial MP:0005382 10.11 CSF1 DKK1 IL17A IL1B IL1R1 PLAU
8 integument MP:0010771 9.97 CSF1 IL1B IL1R1 IL1RN IL6 PLAU
9 muscle MP:0005369 9.86 CSF1 IL1R1 IL6 PLAU RARRES2 SERPINB2
10 neoplasm MP:0002006 9.81 IL1B IL1R1 IL6 IL6R PLAU SERPINB2
11 respiratory system MP:0005388 9.61 CSF1 DKK1 IL17A IL1R1 IL6 PLAU
12 skeleton MP:0005390 9.4 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN

Drugs & Therapeutics for Joint Disorders

Drugs for Joint Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1023)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
2
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 185243-69-0
3
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
5
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
6
Thrombin Approved, Investigational Phase 4,Not Applicable
7
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
8
Rivaroxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 366789-02-8
9
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
10
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 124-94-7 31307
11
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
12
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
13
Dalteparin Approved Phase 4,Phase 3 9005-49-6
14
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 46507594 772
15
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
16
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 15307-86-5 3033
17
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3416-24-8 439213
18
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
19
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
21
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 74103-06-3, 66635-83-4 3826
22
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
23
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 378-44-9 9782
24
Iron Approved, Experimental Phase 4,Phase 1,Phase 2,Not Applicable 7439-89-6, 15438-31-0 27284 23925
25
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
26
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 156391 1302
27
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
28
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
29
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
30
Hyoscyamine Approved Phase 4,Not Applicable 101-31-5 64692
31
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
32
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
33
Norepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-41-2 439260
34
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 38396-39-3, 2180-92-9 2474
35
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
36
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
37
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 332348-12-6 10237
38
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Not Applicable 118-42-3 3652
39
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 599-79-1 5359476 5353980
40
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
41
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
42
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
43
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 202409-33-4 123619
44
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 174722-31-7 10201696
45
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 16590-41-3 5360515
46
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
47
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0
48
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
49
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
50
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2921-57-5

Interventional clinical trials:

(show top 50) (show all 8009)
# Name Status NCT ID Phase Drugs
1 Study of Adalimumab to Lower Cardiovascular Risk in RA Patients With Well Controlled Joint Disease Unknown status NCT01893996 Phase 4 Adalimumab;Placebo
2 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
3 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
4 A Clinical Phenotype Based Individualized Prophylaxis in Chinese Hemophilia A Children Unknown status NCT02999308 Phase 4
5 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
6 The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis Unknown status NCT00808496 Phase 4
7 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
8 Birmingham Hip Resurfacing (BHR) Study: Implantation of a Hip Resurfacing Endoprosthesis Unknown status NCT00180206 Phase 4
9 W-Shaped Acetabular Angular Plate (WAAP) Versus Reconstruction Plate Unknown status NCT02327949 Phase 4
10 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4 Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
11 Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty Unknown status NCT03328832 Phase 4 Topical tranexamic acid;Floseal®;rivaroxaban (10mg)
12 Outcomes of Injections in Patients Waiting for Total Knee Replacement Unknown status NCT03090698 Phase 4 Hylan G-F 20;Triamcinolone
13 The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients Unknown status NCT03067194 Phase 4 Celecoxib 100 MG;Celecoxib 200mg
14 Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02949466 Phase 4 Triamcinolone
15 Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty Unknown status NCT02865174 Phase 4 Topical tranexamic acid;Floseal®;Enoxaparin
16 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
17 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
18 Clinical Study of Artz in the Treatment of Knee Osteoarthritis Unknown status NCT02826031 Phase 4 Sodium Hyaluronate Injection;DICL-SR
19 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
20 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
21 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
22 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
23 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
24 26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle Unknown status NCT02627859 Phase 4
25 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
26 Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
27 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
28 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
29 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
30 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
31 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
32 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
33 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
34 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
35 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
36 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
37 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
38 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
39 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
40 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
41 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
42 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
43 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
44 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
45 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
46 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
47 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
48 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
49 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
50 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg

Search NIH Clinical Center for Joint Disorders

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Joint Disorders cell therapies at LifeMap Discovery.

Genetic Tests for Joint Disorders

Anatomical Context for Joint Disorders

MalaCards organs/tissues related to Joint Disorders:

42
Bone, Testes, Eye, Bone Marrow, Breast, Skin, B Cells

Publications for Joint Disorders

Articles related to Joint Disorders:

(show top 50) (show all 2822)
# Title Authors Year
1
Arthropathy in acromegaly: a questionnaire-based estimation of motor disability and its relation with quality of life and work productivity. ( 31032537 )
2019
2
Massive acromio-clavicular joint ganglion cyst associated with cuff tear arthropathy and acromioclavicular joint arthritis with normal functional shoulder-A case report. ( 31061582 )
2019
3
MR neurography showed brachial plexus abnormalities in syringomyelia with shoulder Charcot arthropathy: a case report. ( 30892961 )
2019
4
Risks and patient outcomes of surgical intervention for hemophilic arthropathy. ( 30929534 )
2019
5
Overlapping features of rapidly progressive osteoarthrosis and Charcot arthropathy. ( 30936675 )
2019
6
Using synovial volume measurement by MRI to evaluate the effect of 32P Radiation synovectomy on hemophilic arthropathy patients. ( 30958324 )
2019
7
Monitoring Bone Health in Children with Hemophilic Arthropathy: Where Do We Stand? ( 30972699 )
2019
8
Chronic postrheumatic fever arthropathy. ( 30978163 )
2019
9
Commentary on the paper: "Hindfoot malalignment in adults with haemophilic ankle arthropathy: The importance of early detection and orthotic treatment": Authored by: De la Corte-Rodriguez, Rodriguez-Merchan, Alvarez-Roman, Martin-Salces, Jimenez-Yuste. ( 30994252 )
2019
10
Low-dose computed tomography as diagnostic tool in calcium pyrophosphate deposition disease arthropathy: focus on ligamentous calcifications of the wrist. ( 31025927 )
2019
11
Familial Mediterranean Fever Gene Mutations and Gout as an Auto-Inflammatory Arthropathy. ( 31097862 )
2019
12
Imaging of Progressive Neuropathic Arthropathy of the Shoulder. ( 29979203 )
2019
13
Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment. ( 30128683 )
2019
14
Ultrasound-Guided Prolotherapy for Acromial Enthesopathy and Acromioclavicular Joint Arthropathy: A Single-Arm Prospective Study. ( 30171616 )
2019
15
Models of arthropathy: what can we learn from them to improve patient care? ( 30239955 )
2019
16
Glenohumeral Dislocation Arthropathy: Etiology, Diagnosis, and Management. ( 30278009 )
2019
17
Corrigendum to "Primary Total Knee Arthroplasty in Patients With Neuropathic (Charcot) Arthropathy: Contemporary Results" [Journal of Arthroplasty 33 (2018) 2815-2820]. ( 30293755 )
2019
18
Subclinical crystal arthropathy: a silent contributor to inflammation and functional disability in knees with osteoarthritis-an ultrasound study. ( 30327988 )
2019
19
Assessment of tensile mechanical properties of the Achilles tendon in adult patients with haemophilic arthropathy. Reproducibility study. ( 30375147 )
2019
20
Clinical effectiveness and safety of the extended humeral head arthroplasty for selected patients with rotator cuff tear arthropathy. ( 30392935 )
2019
21
Clinicopathological case: rapid cognitive decline and myoclonus associated with fever, arthropathy and scleritis. ( 30425126 )
2019
22
Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score. ( 30444298 )
2019
23
Charcot spinal arthropathy presenting as adjacent segment disease after lumbar spinal fusion surgery in Parkinson's disease: A case report. ( 30446371 )
2019
24
Glenoid morphology is associated with the development of instability arthropathy. ( 30509607 )
2019
25
Bleed volume of experimental knee haemarthrosis correlates with the subsequent degree of haemophilic arthropathy. ( 30648774 )
2019
26
Hindfoot malalignment in adults with haemophilic ankle arthropathy: The importance of early detection and orthotic treatment. ( 30664313 )
2019
27
Poor patient-reported outcome after shoulder replacement in young patients with cuff-tear arthropathy: a matched-pair analysis from the Danish Shoulder Arthroplasty Registry. ( 30669910 )
2019
28
Serum Sclerostin Level and Bone Mineral Density in Pediatric Hemophilic Arthropathy. ( 30671760 )
2019
29
Arthropathy and Cutaneous Eruption in a Patient With Cystic Fibrosis. ( 30673074 )
2019
30
Clinical manifestations and risk factors of arthropathy in cystic fibrosis. ( 30704701 )
2019
31
Assessment of haemophilic arthropathy through balance analysis: a promising tool. ( 30714398 )
2019
32
The Prevalence of Asymptomatic Cervical and Lumbar Facet Arthropathy: A Computed Tomography Study. ( 30744307 )
2019
33
Neuromuscular control during gait in people with haemophilic arthropathy. ( 30748060 )
2019
34
Syphilis with Charcot arthropathy: a case report. ( 30758895 )
2019
35
Can a functional difference be detected in reverse arthroplasty with 135° versus 155° prosthesis for the treatment of rotator cuff arthropathy: a prospective randomized study. ( 30773441 )
2019
36
Facet arthropathy evaluation: CT or MRI? ( 30796571 )
2019
37
Humeral head histopathological changes in cuff tear arthropathy. ( 30798768 )
2019
38
Neuropathic arthropathy of the shoulder joint caused by syringomyelia: report of a rare case. ( 30850574 )
2019
39
Pressure distribution under the contralateral limb in Charcot arthropathy with different walking speeds. ( 30851651 )
2019
40
Long-term results of total knee arthroplasty in hemophilic arthropathy. ( 30852987 )
2019
41
An exploratory comparison of single intra-articular injection of platelet-rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee. ( 30866117 )
2019
42
Outpatient treatment for haemophilic arthropathy with radiosynovectomy: Radiation dose to family members. ( 30866133 )
2019
43
Anterior osteophyte resection of the ankle joint to increase range of motion in haemophilic ankle arthropathy. ( 30866148 )
2019
44
Destructive arthropathy of the shoulder complicating a cervical ependymoma. ( 30890366 )
2019
45
Is splint therapy required after arthrocentesis to improve outcome in the management of temporomandibular joint disorders? A systematic review and meta-analysis. ( 30393091 )
2019
46
Clinical Applications of Positron Emission Tomography in the Evaluation of Spine and Joint Disorders. ( 30420222 )
2019
47
Correlations between the Helkimo indices and the maximal mandibular excursion capacities of patients with temporomandibular joint disorders. ( 30691742 )
2019
48
Correlation of magnetic resonance imaging grades with cytokine levels of synovial fluid of patients with temporomandibular joint disorders: a cross-sectional study. ( 30729345 )
2019
49
THE USE OF BOTULINUM TOXIN-A IN THE TREATMENT OF MUSCULAR TEMPOROMANDIBULAR JOINT DISORDERS. ( 30807862 )
2019
50
Comparison of the effectiveness of high resolution ultrasound with MRI in patients with temporomandibular joint dısorders. ( 30810356 )
2019

Variations for Joint Disorders

Expression for Joint Disorders

Search GEO for disease gene expression data for Joint Disorders.

Pathways for Joint Disorders

Pathways related to Joint Disorders according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
2
Show member pathways
13.89 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
3
Show member pathways
13.71 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
4
Show member pathways
13.57 IL11 IL17A IL18R1 IL1B IL1R1 IL6
5
Show member pathways
13.4 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
6
Show member pathways
13.33 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
7
Show member pathways
13.21 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
8 12.79 CSF1 IL1B IL1R1 IL1R2 TNF
9
Show member pathways
12.77 IL1B IL1R1 IL1R2 IL6 TIMP1 TNF
10
Show member pathways
12.67 IL17A IL18R1 IL1B IL1R1 IL6 IL6R
11
Show member pathways
12.66 IL17A IL18R1 IL1B IL6 TIMP1 TNF
12 12.61 IL17A IL1B IL1RN TNF TNFSF11
13
Show member pathways
12.57 IL17A IL1B IL6 TNF
14
Show member pathways
12.42 IL17A IL1B IL6 IL6R MMP3 TNF
15 12.37 IL1R1 IL1R2 IL6 TNF
16
Show member pathways
12.36 CSF1 IL1B IL6 TNF
17
Show member pathways
12.33 IL1B IL1R1 IL6 TNF
18
Show member pathways
12.33 IL1B IL1R1 IL1R2 IL1RN
19
Show member pathways
12.31 IL17A IL1B IL6 TIMP1 TNF
20 12.29 IL1R2 IL6 MMP3 PLAU
21
Show member pathways
12.28 IL18R1 IL1B IL1R1 IL1R2 IL1RN IL6
22
Show member pathways
12.26 IL11 IL1B IL1R1 IL6 TNF
23 12.25 IL1B IL1RN IL6 IL6R TNF
24
Show member pathways
12.15 IL11 IL17A IL18R1 IL1B IL1R1 IL6
25 12.14 IL1B IL1R1 IL1R2 TNF
26 12.13 CSF1 IL1B IL1R1 TNF TNFSF11
27
Show member pathways
12.09 IL1B IL6 MMP3 TNF
28 12.07 CSF1 IL18R1 IL1B IL6 MMP3 TNF
29 12.06 IL1B IL1R1 IL6 TNF
30
Show member pathways
12.06 IL17A IL18R1 IL1B IL1R1 IL6 IL6R
31 12.05 IL1B IL6 IL6R PLAU SERPINB2
32 12.04 CSF1 IL11 IL6 TNF
33 12 IL1B IL1R1 PLAU TNF TNFSF11
34 11.99 IL1B IL1R1 IL1R2 IL6 TNF
35 11.97 IL17A IL1B IL6 IL6R MMP3 TIMP1
36 11.92 IL6 IL6R TIMP1
37 11.92 IL1B IL6 TNF
38
Show member pathways
11.91 MMP3 TIMP1 TNF
39
Show member pathways
11.88 IL17A IL6 IL6R
40 11.87 IL17A IL1B IL1R1 TNF
41 11.83 CSF1 IL1B IL6 TNF
42 11.79 IL1B IL6 TNF
43
Show member pathways
11.76 IL1B IL6 MMP3 TNF
44 11.76 IL1B IL6 PLAU TIMP1 TNF
45 11.76 IL17A IL1B IL1RN IL6 MMP3 TNF
46 11.74 CSF1 IL11 IL1B IL1R1 IL1R2 IL6
47 11.68 MMP3 PLAU TIMP1
48
Show member pathways
11.66 IL11 IL6 IL6R
49 11.63 IL1B IL6 TNF
50 11.59 IL1B IL6 TNF TNFSF11

GO Terms for Joint Disorders

Cellular components related to Joint Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CSF1 DKK1 IL11 IL17A IL1B IL1RN
2 extracellular region GO:0005576 9.55 CSF1 DKK1 IL11 IL17A IL1B IL1R1
3 interleukin-6 receptor complex GO:0005896 9.16 IL6 IL6R
4 plasma membrane GO:0005886 10.03 CSF1 DKK1 IL18R1 IL1R1 IL1R2 IL1RAPL2

Biological processes related to Joint Disorders according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.99 DKK1 IL6 SERPINB2 TIMP1
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 IL1B IL1RN TNF TNFSF11
3 cellular response to lipopolysaccharide GO:0071222 9.94 IL1B IL1RN IL6 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL18R1 IL1B IL6 TNF TNFSF11
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL1B IL6 TNF TNFSF11
6 immune response GO:0006955 9.91 IL17A IL18R1 IL1B IL1R1 IL1R2 IL1RN
7 defense response to Gram-positive bacterium GO:0050830 9.87 IL6 RARRES2 TNF
8 positive regulation of JNK cascade GO:0046330 9.87 IL1B IL1RN TNF TNFSF11
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.86 IL11 IL6 IL6R
10 defense response to Gram-negative bacterium GO:0050829 9.85