MCID: JVN059
MIFTS: 35

Juvenile Ankylosing Spondylitis

Categories: Immune diseases

Aliases & Classifications for Juvenile Ankylosing Spondylitis

MalaCards integrated aliases for Juvenile Ankylosing Spondylitis:

Name: Juvenile Ankylosing Spondylitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040092
ICD10 33 M08.1
UMLS 73 C0409675

Summaries for Juvenile Ankylosing Spondylitis

Disease Ontology : 12 An autoimmune disease of musculoskeletal system that is an ankylosing spondylitis with onset during childhood.

MalaCards based summary : Juvenile Ankylosing Spondylitis is related to spondyloarthropathy 1 and spondylitis. An important gene associated with Juvenile Ankylosing Spondylitis is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. Affiliated tissues include lung, bone and heart, and related phenotypes are cellular and hematopoietic system

Related Diseases for Juvenile Ankylosing Spondylitis

Diseases related to Juvenile Ankylosing Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 31.2 MRAP TNF TNFRSF1B
2 spondylitis 30.6 IL1RN IL6 TNF TNFRSF1B
3 bursitis 30.5 MRAP PHB2
4 tendinitis 30.3 MRAP PHB2
5 enthesopathy 30.2 MEFV MRAP PHB2
6 arthritis 29.5 IL1RN IL6 TNF TNFRSF1B
7 atlantoaxial subluxation 10.3
8 posterior scleritis 10.2 MRAP TNF
9 balanitis 10.2 MRAP PHB2
10 diffuse infiltrative lymphocytosis syndrome 10.2 MRAP TNF
11 urethritis 10.2 MRAP PHB2
12 coccidiosis 10.2 MRAP TNF
13 inclusion conjunctivitis 10.2 MRAP TNF
14 conjunctival disease 10.2 MRAP TNF
15 tenosynovitis 10.2 MRAP TNFRSF1B
16 glaucomatocyclitic crisis 10.2 MRAP TNF
17 orbital plasma cell granuloma 10.2 MRAP TNFRSF1B
18 skin sarcoidosis 10.2 TNF TNFRSF1B
19 chronic orbital inflammation 10.2 MRAP TNFRSF1B
20 chronic gonococcal salpingitis 10.2 TNF TNFRSF1B
21 granulomatous dermatitis 10.2 TNF TNFRSF1B
22 rheumatoid lung disease 10.2 TNF TNFRSF1B
23 peroneal neuropathy 10.2 TNF TNFRSF1B
24 urethral syndrome 10.2 MRAP PHB2
25 specific bursitis often of occupational origin 10.2 MEFV MRAP
26 olecranon bursitis 10.2 MEFV MRAP
27 autoinflammation, panniculitis, and dermatosis syndrome 10.2 MEFV TNF
28 chronic salpingitis 10.2 TNF TNFRSF1B
29 erysipelas 10.2 MEFV TNF
30 relapsing fever 10.2 MEFV TNF
31 byssinosis 10.1 MEFV MRAP
32 spondylarthropathy 10.1 CD80 TNF
33 cogan syndrome 10.1 TNF TNFRSF1B
34 blau syndrome 10.1 MEFV TNF
35 melkersson-rosenthal syndrome 10.1 TNF TNFRSF1B
36 uveitis 10.1
37 pyoderma 10.1 MEFV TNF
38 pyoderma gangrenosum 10.1 MEFV TNF
39 vulvar vestibulitis syndrome 10.1 IL1RN TNF
40 aseptic meningitis 10.1 IL1RN TNF
41 chondromalacia 10.1 IL1RN TNFRSF1B
42 acute salpingitis 10.1 MRAP TNF TNFRSF1B
43 panuveitis 10.1 MRAP TNF TNFRSF1B
44 human immunodeficiency virus infectious disease 10.1 IL6 TNF
45 pleurisy 10.1 MEFV TNF
46 myelitis 10.1 IL6 TNF
47 scorpion envenomation 10.0 IL6 TNF
48 iritis 10.0 MRAP PHB2 TNFRSF1B
49 leukomalacia 10.0 IL6 TNF
50 angioimmunoblastic lymphadenopathy with dysproteinemia 10.0 IL6 TNF

Graphical network of the top 20 diseases related to Juvenile Ankylosing Spondylitis:



Diseases related to Juvenile Ankylosing Spondylitis

Symptoms & Phenotypes for Juvenile Ankylosing Spondylitis

MGI Mouse Phenotypes related to Juvenile Ankylosing Spondylitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 CD80 IL1RN IL6 MEFV PHB2 TNF
2 hematopoietic system MP:0005397 9.43 CD80 IL1RN IL6 MEFV TNF TNFRSF1B
3 integument MP:0010771 9.1 IL1RN IL6 MEFV PHB2 TNF TNFRSF1B

Drugs & Therapeutics for Juvenile Ankylosing Spondylitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The CARRA Registry Completed NCT01697254
2 German Spondyloarthritis Inception Cohort Recruiting NCT01277419

Search NIH Clinical Center for Juvenile Ankylosing Spondylitis

Genetic Tests for Juvenile Ankylosing Spondylitis

Anatomical Context for Juvenile Ankylosing Spondylitis

MalaCards organs/tissues related to Juvenile Ankylosing Spondylitis:

41
Lung, Bone, Heart, Lymph Node, Eye, Spinal Cord, Pancreas

Publications for Juvenile Ankylosing Spondylitis

Articles related to Juvenile Ankylosing Spondylitis:

(show all 36)
# Title Authors Year
1
The Disease of the Italian Poet Giacomo Leopardi (1798-1837): A Case of Juvenile Ankylosing Spondylitis in the 19th Century? ( 28489625 )
2017
2
Recurrent macrophage activation syndrome since toddler age in an adolescent boy with HLA B27 positive juvenile ankylosing spondylitis. ( 27826329 )
2016
3
Juvenile ankylosing spondylitis in Turner syndrome. ( 25073991 )
2013
4
Disability impact on quality of life in Mexican adults with juvenile idiopathic arthritis and juvenile ankylosing spondylitis. ( 18173931 )
2007
5
Spontaneous atlantoaxial subluxation as a presenting manifestation of juvenile ankylosing spondylitis in a female HLA-B27-negative patient. ( 15798910 )
2005
6
Juvenile ankylosing spondylitis--is it the same disease as adult ankylosing spondylitis? ( 14655021 )
2005
7
Infliximab in two patients with juvenile ankylosing spondylitis. ( 14648110 )
2004
8
Juvenile ankylosing spondylitis with uveitis. ( 12931754 )
2003
9
Tamale foot: deposit of acid mucopolysaccharides in the synovial sheaths of extensor tendons of the foot, resembling tendinitis, in a patient with juvenile ankylosing spondylitis. ( 10914870 )
2000
10
Shoulder, knee, and hip pain as initial symptoms of juvenile ankylosing spondylitis: a case report. ( 9475141 )
1998
11
A case of juvenile ankylosing spondylitis and Crohn's disease. ( 9223928 )
1997
12
Osteochondroma in a patient with juvenile ankylosing spondylitis associated with idiopathic thrombocytopenic purpura and alpha thalassemia. ( 8774559 )
1996
13
Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis. ( 8847233 )
1995
14
Prevalence of cardiac manifestations of juvenile ankylosing spondylitis. ( 7900679 )
1995
15
Chest expansion in healthy adolescents and patients with the seronegative enthesopathy and arthropathy syndrome or juvenile ankylosing spondylitis. ( 8308785 )
1993
16
Juvenile ankylosing spondylitis in X-linked agammaglobulinaemia. ( 8402008 )
1993
17
Immunological study in three families of juvenile ankylosing spondylitis. ( 1514412 )
1992
18
Juvenile ankylosing spondylitis. ( 1561399 )
1992
19
Uveitis of juvenile ankylosing spondylitis. ( 3418632 )
1988
20
Atlantoaxial subluxation in juvenile ankylosing spondylitis. ( 3619967 )
1987
21
Antibodies to peptidoglycan in juvenile ankylosing spondylitis. ( 3625658 )
1987
22
Tarsal ankylosis in juvenile ankylosing spondylitis. ( 3761186 )
1986
23
Bilateral deep infrapatellar bursitis associated with tibial tuberosity enthesopathy in a case of juvenile ankylosing spondylitis. ( 4048762 )
1985
24
Juvenile ankylosing spondylitis and HLA B27 homozygosity. ( 3873692 )
1985
25
Rapidly progressive aortic incompetence in juvenile ankylosing spondylitis: a case report. ( 6233987 )
1984
26
Enthesopathic erosive lesions of patella and tibial tuberosity in juvenile ankylosing spondylitis. Anatomico-radiological study of a case with tibial bursitis. ( 6416967 )
1983
27
Spontaneous atlantoaxial subluxation as a presenting manifestation of juvenile ankylosing spondylitis. A case report. ( 7071666 )
1982
28
Juvenile ankylosing spondylitis and aortic regurgitation: a case presentation. ( 7279473 )
1981
29
Aortic insufficiency in association with juvenile ankylosing spondylitis. ( 480020 )
1979
30
Atlantoaxial subluxation in juvenile ankylosing spondylitis. ( 690785 )
1978
31
Juvenile ankylosing spondylitis, its clinical features and HLA-B27. ( 836220 )
1977
32
Juvenile ankylosing spondylitis. ( 928708 )
1977
33
Juvenile ankylosing spondylitis. Report of three cases. ( 5164928 )
1971
34
Juvenile ankylosing spondylitis. ( 5315295 )
1971
35
Juvenile ankylosing spondylitis. ( 6025361 )
1967
36
Juvenile ankylosing spondylitis. ( 13725760 )
1960

Variations for Juvenile Ankylosing Spondylitis

Expression for Juvenile Ankylosing Spondylitis

Search GEO for disease gene expression data for Juvenile Ankylosing Spondylitis.

Pathways for Juvenile Ankylosing Spondylitis

Pathways related to Juvenile Ankylosing Spondylitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CD80 IL1RN IL6 TNF TNFRSF1B
2
Show member pathways
12.71 CD80 IL6 MEFV TNF
3
Show member pathways
12.58 CD80 IL6 TNF TNFRSF1B
4
Show member pathways
11.92 IL1RN IL6 TNF
5 11.82 IL1RN IL6 TNF
6
Show member pathways
11.69 CD80 IL6 TNF
7 11.61 CD80 IL6 TNF
8 11.55 IL6 TNF TNFRSF1B
9 11.47 IL6 TNF TNFRSF1B
10
Show member pathways
11.33 TNF TNFRSF1B
11 11.31 IL6 TNF
12 11.3 IL6 TNF
13 11.29 CD80 IL6 TNF
14 11.26 IL6 TNF
15 11.15 IL6 TNF
16 11.14 IL6 TNF
17 11.11 CD80 TNFRSF1B
18 11.11 CD80 IL1RN IL6 TNF
19 11.09 TNF TNFRSF1B
20 11.08 IL6 TNF
21 11.06 IL6 TNF
22 11.01 IL6 TNF
23 10.93 CD80 IL6 TNF
24 10.85 IL6 TNF
25 10.74 IL6 TNF
26 10.71 CD80 IL1RN IL6 TNF TNFRSF1B

GO Terms for Juvenile Ankylosing Spondylitis

Biological processes related to Juvenile Ankylosing Spondylitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.67 IL6 PHB2 TNF
2 immune response GO:0006955 9.65 CD80 IL1RN IL6 TNF TNFRSF1B
3 negative regulation of fat cell differentiation GO:0045599 9.58 IL6 TNF
4 extrinsic apoptotic signaling pathway GO:0097191 9.58 TNF TNFRSF1B
5 response to glucocorticoid GO:0051384 9.58 IL1RN IL6 TNF
6 positive regulation of JUN kinase activity GO:0043507 9.57 IL1RN TNF
7 negative regulation of neurogenesis GO:0050768 9.56 IL6 TNF
8 protein import into nucleus, translocation GO:0000060 9.55 PHB2 TNF
9 inflammatory response GO:0006954 9.55 IL1RN IL6 MEFV TNF TNFRSF1B
10 positive regulation of chemokine production GO:0032722 9.54 IL6 TNF
11 positive regulation of interleukin-6 production GO:0032755 9.54 IL1RN IL6 TNF
12 positive regulation of glial cell proliferation GO:0060252 9.52 IL6 TNF
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.51 TNF TNFRSF1B
14 negative regulation of lipid storage GO:0010888 9.48 IL6 TNF
15 positive regulation of neuroinflammatory response GO:0150078 9.46 IL6 TNF
16 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.43 IL1RN IL6
17 cytokine-mediated signaling pathway GO:0019221 9.35 CD80 IL1RN IL6 TNF TNFRSF1B
18 chronic inflammatory response to antigenic stimulus GO:0002439 9.32 IL1RN TNF
19 cellular response to lipopolysaccharide GO:0071222 9.02 CD80 IL1RN IL6 TNF TNFRSF1B

Molecular functions related to Juvenile Ankylosing Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL1RN IL6 TNF

Sources for Juvenile Ankylosing Spondylitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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