MCID: JVN059
MIFTS: 24

Juvenile Ankylosing Spondylitis

Categories: Bone diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Juvenile Ankylosing Spondylitis

MalaCards integrated aliases for Juvenile Ankylosing Spondylitis:

Name: Juvenile Ankylosing Spondylitis 12 15 32

Classifications:



External Ids:

Disease Ontology 12 DOID:0040092
SNOMED-CT 67 201802002
ICD10 32 M08.1
UMLS 70 C0409675

Summaries for Juvenile Ankylosing Spondylitis

Disease Ontology : 12 An autoimmune disease of musculoskeletal system that is an ankylosing spondylitis with onset during childhood.

MalaCards based summary : Juvenile Ankylosing Spondylitis is related to spondylitis and spondyloarthropathy 1. An important gene associated with Juvenile Ankylosing Spondylitis is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Apoptosis-related network due to altered Notch3 in ovarian cancer and Interleukin-10 signaling.

Related Diseases for Juvenile Ankylosing Spondylitis

Diseases in the Juvenile Ankylosing Spondylitis family:

Ankylosing Spondylitis 1 Ankylosing Spondylitis 2
Ankylosing Spondylitis 3

Diseases related to Juvenile Ankylosing Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 spondylitis 31.6 TNF ERAP1
2 spondyloarthropathy 1 30.9 TNF MRAP IL1RN ERAP1
3 iridocyclitis 30.6 TNF MRAP
4 enthesopathy 30.3 TNF MEFV ERAP1
5 purpura 29.9 TNF MEFV
6 inflammatory spondylopathy 10.9
7 juvenile rheumatoid arthritis 10.7
8 uveitis 10.3
9 ankylosis 10.3
10 arthropathy 10.3
11 whipple disease 10.2 TNF MRAP
12 urethritis 10.2 TNF MRAP
13 autoimmune disease 10.2
14 frozen shoulder 10.2
15 bursitis 10.2
16 reactive arthritis 10.2
17 cheilitis 10.1 TNF ERAP1
18 vulvar vestibulitis syndrome 10.1 TNF IL1RN
19 pouchitis 10.1 TNF IL1RN
20 aortitis 10.1 TNF IL1RN
21 pustulosis of palm and sole 10.1 TNF IL1RN
22 idiopathic neutropenia 10.1 TNF IL1RN
23 autoimmune disease of skin and connective tissue 10.1 TNF ERAP1
24 helicobacter pylori infection 10.1 TNF IL1RN
25 dengue shock syndrome 10.1 TNF IL1RN
26 aseptic meningitis 10.1 TNF IL1RN
27 hereditary periodic fever syndrome 10.1 TNF MEFV
28 systemic onset juvenile idiopathic arthritis 10.1 TNF MEFV
29 palindromic rheumatism 10.1 TNF MEFV
30 gastric ulcer 10.1 TNF IL1RN
31 erysipelas 10.1 TNF MEFV
32 bacterial sepsis 10.1 TNF IL1RN
33 pyoderma 10.0 TNF MEFV
34 pyoderma gangrenosum 10.0 TNF MEFV
35 relapsing fever 10.0 TNF MEFV
36 hypersensitivity vasculitis 10.0 TNF MEFV
37 hypersensitivity reaction type iii disease 10.0 TNF MEFV
38 bacterial vaginosis 10.0 TNF IL1RN
39 pericardium disease 10.0 TNF MEFV
40 pharyngitis 10.0 TNF MEFV
41 fasciitis 10.0 TNF IL1RN
42 sebaceous gland disease 10.0 TNF MEFV
43 hidradenitis 10.0 TNF MEFV
44 hidradenitis suppurativa 10.0 TNF MEFV
45 silicosis 10.0 TNF IL1RN
46 myositis 10.0
47 thrombocytopenic purpura, autoimmune 10.0
48 alpha-thalassemia 10.0
49 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
50 tendinitis 10.0

Graphical network of the top 20 diseases related to Juvenile Ankylosing Spondylitis:



Diseases related to Juvenile Ankylosing Spondylitis

Symptoms & Phenotypes for Juvenile Ankylosing Spondylitis

Drugs & Therapeutics for Juvenile Ankylosing Spondylitis

Search Clinical Trials , NIH Clinical Center for Juvenile Ankylosing Spondylitis

Genetic Tests for Juvenile Ankylosing Spondylitis

Anatomical Context for Juvenile Ankylosing Spondylitis

Publications for Juvenile Ankylosing Spondylitis

Articles related to Juvenile Ankylosing Spondylitis:

(show top 50) (show all 92)
# Title Authors PMID Year
1
Do geography and ethnicity play a role in juvenile Spondyloarthritis? A multi-center binational retrospective study. 61
33407634 2021
2
Unexpected increase of aortic stiffness in juvenile Spondyloarthropathies. 61
32938508 2020
3
Bone tumors developed in patients with juvenile inflammatory arthritis after anti-TNF╬▒ therapy. 61
30185135 2018
4
Classifications and imaging of juvenile spondyloarthritis. 61
30451405 2018
5
The Disease of the Italian Poet Giacomo Leopardi (1798-1837): A Case of Juvenile Ankylosing Spondylitis in the 19th Century? 61
28489625 2017
6
Recurrent macrophage activation syndrome since toddler age in an adolescent boy with HLA B27 positive juvenile ankylosing spondylitis. 61
27826329 2016
7
Biologic agents in juvenile spondyloarthropathies. 61
26968522 2016
8
Differential plasma microRNAs expression in juvenile idiopathic arthritis. 61
26054419 2016
9
Juvenile ankylosing spondylitis in Turner syndrome. 61
25073991 2013
10
Pediatric fibromyalgia. 61
23024967 2012
11
Diagnosis and treatment of enthesitis-related arthritis. 61
23236258 2012
12
Atypical infectious mononucleosis in a patient receiving tumor necrosis factor alpha inhibitory treatment. 61
19034455 2009
13
[Analysis of diagnosis and treatment for juvenile ankylosing spondylitis in 5 cases]. 61
19105492 2008
14
Central nervous system involvement in pediatric rheumatic diseases: current concepts in treatment. 61
18537653 2008
15
Disability impact on quality of life in Mexican adults with juvenile idiopathic arthritis and juvenile ankylosing spondylitis. 61
18173931 2007
16
[Other rheumatic diseases with uveitis besides juvenile idiopathic arthritis]. 61
17594615 2007
17
Juvenile psoriatic arthritis carrying familial Mediterranean fever gene mutations in a 14-year-old Turkish girl. 61
17408446 2007
18
Juvenile spondyloarthropathies associated with Mycoplasma pneumoniae infection. 61
16391883 2006
19
Chronic musculoskeletal pain in children: part II. Rheumatic causes. 61
16883927 2006
20
Spontaneous atlantoaxial subluxation as a presenting manifestation of juvenile ankylosing spondylitis in a female HLA-B27-negative patient. 61
15798910 2005
21
[Importance of the new biologicals and cytokine antagonists in the treatment of juvenile idiopathic arthritis (JIA)]. 61
15965816 2005
22
Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study. 61
15940778 2005
23
Juvenile ankylosing spondylitis--is it the same disease as adult ankylosing spondylitis? 61
14655021 2005
24
Infliximab in two patients with juvenile ankylosing spondylitis. 61
14648110 2004
25
Fever of unknown origin in Turkey: evaluation of 87 cases during a nine-year-period of study. 61
14667795 2004
26
Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria. 61
14528529 2003
27
Juvenile ankylosing spondylitis with uveitis. 61
12931754 2003
28
Tamale foot: deposit of acid mucopolysaccharides in the synovial sheaths of extensor tendons of the foot, resembling tendinitis, in a patient with juvenile ankylosing spondylitis. 61
10914870 2000
29
Neuroendocrine immune features of pediatric inflammatory rheumatic diseases. 61
10415595 1999
30
Spondyloarthropathies in childhood. 61
9890099 1998
31
Shoulder, knee, and hip pain as initial symptoms of juvenile ankylosing spondylitis: a case report. 61
9475141 1998
32
Sulphasalazine in the treatment of children with chronic arthritis. 61
9805178 1998
33
Sulphasalazine therapy in chronic uveitis of children with chronic arthritis. 61
9346269 1997
34
A case of juvenile ankylosing spondylitis and Crohn's disease. 61
9223928 1997
35
Endocrine aspects of paediatric rheumatic diseases. 61
8911653 1996
36
Osteochondroma in a patient with juvenile ankylosing spondylitis associated with idiopathic thrombocytopenic purpura and alpha thalassemia. 61
8774559 1996
37
Juvenile psoriatic arthritis: followup and evaluation of diagnostic criteria. 61
8838527 1996
38
Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis. 61
8847233 1995
39
Prevalence of cardiac manifestations of juvenile ankylosing spondylitis. 61
7900679 1995
40
[Childhood and juvenile ankylosing spondylitis]. 61
8297992 1993
41
[Childhood and juvenile ankylosing spondylitis?]. 61
8297993 1993
42
Chest expansion in healthy adolescents and patients with the seronegative enthesopathy and arthropathy syndrome or juvenile ankylosing spondylitis. 61
8308785 1993
43
Juvenile ankylosing spondylitis in X-linked agammaglobulinaemia. 61
8402008 1993
44
Immunological study in three families of juvenile ankylosing spondylitis. 61
1514412 1992
45
Juvenile ankylosing spondylitis. 61
1561399 1992
46
[Juvenile ankylosing spondylitis and the joint hypermobility syndrome]. 61
1641701 1992
47
[Spondylodiscitis as a dominant early symptom of juvenile ankylosing spondylitis]. 61
1927065 1991
48
[Juvenile ankylosing spondylitis (JAS) and juvenile rheumatoid arthritis (JRA)]. 61
2092954 1990
49
HLA-B27 and rheumatic diseases of childhood. 61
2082018 1990
50
Pattern of rheumatic diseases in south India. V. Ankylosing spondylitis. A clinical and radiological study. 61
2084081 1990

Variations for Juvenile Ankylosing Spondylitis

Expression for Juvenile Ankylosing Spondylitis

Search GEO for disease gene expression data for Juvenile Ankylosing Spondylitis.

Pathways for Juvenile Ankylosing Spondylitis

Pathways related to Juvenile Ankylosing Spondylitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2 10.31 TNF IL1RN

GO Terms for Juvenile Ankylosing Spondylitis

Biological processes related to Juvenile Ankylosing Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 TNF MEFV IL1RN
2 response to glucocorticoid GO:0051384 9.16 TNF IL1RN
3 humoral immune response GO:0006959 8.96 TNFRSF21 TNF
4 immune system process GO:0002376 8.92 TNFRSF21 RAET1L MEFV ERAP1

Molecular functions related to Juvenile Ankylosing Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1, type II receptor binding GO:0005151 8.62 IL1RN ERAP1

Sources for Juvenile Ankylosing Spondylitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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