MCID: JVN001
MIFTS: 26

Juvenile Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Juvenile Astrocytoma

MalaCards integrated aliases for Juvenile Astrocytoma:

Name: Juvenile Astrocytoma 12 15 71
Pediatric Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3079
NCIt 49 C9022
SNOMED-CT 67 67859002
UMLS 71 C1321865

Summaries for Juvenile Astrocytoma

MalaCards based summary : Juvenile Astrocytoma, also known as pediatric astrocytoma, is related to juvenile pilocytic astrocytoma and grade iii astrocytoma. An important gene associated with Juvenile Astrocytoma is MIR376A1 (MicroRNA 376a-1), and among its related pathways/superpathways are ATP/ITP metabolism and Oncogenic MAPK signaling. Affiliated tissues include spinal cord, cerebellum and brain.

Related Diseases for Juvenile Astrocytoma

Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Juvenile Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 juvenile pilocytic astrocytoma 29.9 LUC7L2 KIAA1549 IDH1
2 grade iii astrocytoma 29.2 TP53 KIAA1549 IDH1
3 low-grade astrocytoma 29.0 TP53 IDH1
4 pleomorphic xanthoastrocytoma 28.3 TP53 KIAA1549 IDH1 FAM131B BRAF
5 childhood cerebellar astrocytic neoplasm 11.3
6 childhood cerebral astrocytoma 11.3
7 pediatric meningioma 10.5 LUC7L2 KIAA1549
8 cerebellar liponeurocytoma 10.4 KIAA1549 FAM131B
9 optic nerve neoplasm 10.4 KIAA1549 FAM131B
10 spinal cord ependymoma 10.3 LUC7L2 KIAA1549
11 spinal cord astrocytoma 10.2 KIAA1549 IDH1
12 adult oligodendroglioma 10.2 KIAA1549 IDH1
13 aicardi-goutieres syndrome 10.2 ADARB2 ADARB1 ADAR
14 clear cell ependymoma 10.1 KIAA1549 IDH1
15 papillary craniopharyngioma 10.1 KIAA1549 FAM131B BRAF
16 glioblastoma multiforme 10.1
17 pigmentation disease 10.1 MIR376A1 ADARB2 ADARB1 ADAR
18 childhood pilocytic astrocytoma 10.1 LUC7L2 KIAA1549 IDH1
19 spinal cord glioma 10.1 LUC7L2 KIAA1549 IDH1
20 myxopapillary ependymoma 10.1 LUC7L2 KIAA1549
21 spinal cancer 10.1 LUC7L2 KIAA1549 IDH1
22 childhood oligodendroglioma 10.0 KIAA1549 IDH1 FAM131B
23 astrocytoma 10.0
24 non-gestational ovarian choriocarcinoma 10.0 TP53 ADAR
25 supratentorial primitive neuroectodermal tumor 9.9 LUC7L2 IDH1
26 astroblastoma 9.9 IDH1 BRAF
27 glioma susceptibility 1 9.9
28 nevus of ota 9.9 TP53 BRAF
29 hyperplastic polyposis syndrome 9.9 TP53 BRAF
30 dysembryoplastic neuroepithelial tumor 9.9 LUC7L2 KIAA1549 IDH1 FAM131B
31 spitz nevus 9.9 TP53 BRAF
32 subependymal glioma 9.9 KIAA1549 FAM131B
33 choriocarcinoma of ovary 9.9 TP53 ADAR
34 meningioma, radiation-induced 9.8
35 meningioma, familial 9.8
36 spinal meningioma 9.8
37 secretory meningioma 9.8
38 lymphoplasmacyte-rich meningioma 9.8
39 thyroid gland anaplastic carcinoma 9.8 TP53 BRAF
40 pilocytic astrocytoma of cerebellum 9.8 KIAA1549 IDH1 FAM131B BRAF
41 cerebellar astrocytoma 9.8 KIAA1549 IDH1 FAM131B BRAF
42 frontal lobe neoplasm 9.8 TP53 IDH1
43 exostoses, multiple, type i 9.7
44 retinoblastoma 9.7
45 mesenchymal cell neoplasm 9.7
46 familial retinoblastoma 9.7
47 chromosomal triplication 9.7
48 glioma 9.7
49 high-grade astrocytoma 9.7
50 breast hemangioma 9.7 TP53 IDH1

Graphical network of the top 20 diseases related to Juvenile Astrocytoma:



Diseases related to Juvenile Astrocytoma

Symptoms & Phenotypes for Juvenile Astrocytoma

Drugs & Therapeutics for Juvenile Astrocytoma

Search Clinical Trials , NIH Clinical Center for Juvenile Astrocytoma

Genetic Tests for Juvenile Astrocytoma

Anatomical Context for Juvenile Astrocytoma

MalaCards organs/tissues related to Juvenile Astrocytoma:

40
Spinal Cord, Cerebellum, Brain, Bone, Breast, Thyroid, Ovary

Publications for Juvenile Astrocytoma

Articles related to Juvenile Astrocytoma:

(show all 23)
# Title Authors PMID Year
1
Germline cancer predisposition variants and pediatric glioma: a population-based study in California. 61
31970404 2020
2
Vestibular Rehabilitation for a Child With Posterior Fossa Syndrome: A Case Report. 61
31815925 2020
3
Intradural Lumbar Migration of Intracranial Neurosurgical Hemostatic Clip Associated with Lumbosciatic Pain. 61
29689402 2018
4
Differentially Expressed Long Non-Coding RNAs Were Predicted to Be Involved in the Control of Signaling Pathways in Pediatric Astrocytoma. 61
27738870 2017
5
Circulating microRNAs as Biomarkers for Pediatric Astrocytomas. 61
29157673 2017
6
Approaches toward improving the prognosis of pediatric patients with glioma: pursuing mutant drug targets with emerging small molecules. 61
25976258 2015
7
A proteomic approach of pediatric astrocytomas: MiRNAs and network insight. 61
24060999 2013
8
Tumor-specific targeted therapy in pediatric astrocytoma demonstrated in a murine model. 61
22989972 2012
9
Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet. 61
20009300 2009
10
Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. 61
19099200 2009
11
Targeting energy metabolism in brain cancer: review and hypothesis. 61
16242042 2005
12
[Transitory cerebellar mutism: report of 2 cases]. 61
10683695 1999
13
MIB-1 labeling index in nonpilocytic astrocytoma of childhood: a study of 101 cases. 61
9635540 1998
14
Pediatric astrocytomas. The Louisville experience: 1978-1988. 61
7977163 1994
15
Patterns and temporal trends in the incidence of malignant disease in children: II. Solid tumours of childhood. 61
7833109 1994
16
Evolution of tumor chromosome abnormalities after therapy in a pediatric astrocytoma. 61
1645227 1991
17
Benign recurrence of a pilocytic cerebellar astrocytoma 36 years after radical removal: case report. 61
2034360 1991
18
Intracranial tumours in the first 18 months of life. 61
1669243 1990
19
A review of astrocytoma in childhood. 61
2518326 1989
20
A study of glial fibrillary acidic protein (GFAP) in childhood brain tumours. 61
6339423 1983
21
The fine structure of the axonal torpedo in Purkinje cells of the human cerebellum. 61
6107881 1980
22
Pilocytic (juvenile) astrocytoma of the optic nerve. The influence of biopsy. 61
662271 1978
23
Juvenile astrocytomas with subarachnoid spread. 61
1255303 1976

Variations for Juvenile Astrocytoma

Expression for Juvenile Astrocytoma

Search GEO for disease gene expression data for Juvenile Astrocytoma.

Pathways for Juvenile Astrocytoma

Pathways related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 ADARB2 ADARB1 ADAR
2
Show member pathways
11.15 KIAA1549 FAM131B BRAF AKAP9 AGTRAP
3
Show member pathways
9.73 ADARB1 ADAR

GO Terms for Juvenile Astrocytoma

Biological processes related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA processing GO:0006396 9.33 ADARB2 ADARB1 ADAR
2 ionotropic glutamate receptor signaling pathway GO:0035235 9.26 GRIK2 GRIA2
3 negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 8.96 ADARB1 ADAR
4 adenosine to inosine editing GO:0006382 8.8 ADARB2 ADARB1 ADAR

Molecular functions related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 9.43 ADARB2 ADARB1 ADAR
2 adenosine deaminase activity GO:0004000 9.33 ADARB2 ADARB1 ADAR
3 ionotropic glutamate receptor activity GO:0004970 9.32 GRIK2 GRIA2
4 tRNA-specific adenosine deaminase activity GO:0008251 9.13 ADARB2 ADARB1 ADAR
5 double-stranded RNA adenosine deaminase activity GO:0003726 8.8 ADARB2 ADARB1 ADAR

Sources for Juvenile Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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