MCID: JVN001
MIFTS: 19

Juvenile Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Juvenile Astrocytoma

MalaCards integrated aliases for Juvenile Astrocytoma:

Name: Juvenile Astrocytoma 12 15 73
Pediatric Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3079
NCIt 50 C9022
UMLS 73 C1321865

Summaries for Juvenile Astrocytoma

MalaCards based summary : Juvenile Astrocytoma, also known as pediatric astrocytoma, is related to childhood cerebellar astrocytic neoplasm and childhood cerebral astrocytoma. An important gene associated with Juvenile Astrocytoma is XYLT1 (Xylosyltransferase 1), and among its related pathways/superpathways is heparan sulfate biosynthesis. Related phenotypes are cellular and embryo

Related Diseases for Juvenile Astrocytoma

Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Juvenile Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 childhood cerebellar astrocytic neoplasm 11.0
2 childhood cerebral astrocytoma 11.0
3 astrocytoma 9.7

Symptoms & Phenotypes for Juvenile Astrocytoma

MGI Mouse Phenotypes related to Juvenile Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 CALR DDX3X ELAVL1 EXT1 SDC4 SULF2
2 embryo MP:0005380 9.63 CALR DDX3X ELAVL1 EXT1 SDC4 SULF2
3 mortality/aging MP:0010768 9.56 CALR DDX3X ELAVL1 EXT1 SDC4 SULF2
4 muscle MP:0005369 9.02 DDX3X SDC4 SULF2 YWHAE CALR

Drugs & Therapeutics for Juvenile Astrocytoma

Search Clinical Trials , NIH Clinical Center for Juvenile Astrocytoma

Genetic Tests for Juvenile Astrocytoma

Anatomical Context for Juvenile Astrocytoma

Publications for Juvenile Astrocytoma

Articles related to Juvenile Astrocytoma:

# Title Authors Year
1
Pilocytic (juvenile) astrocytoma of the optic nerve. The influence of biopsy. ( 662271 )
1978

Variations for Juvenile Astrocytoma

Expression for Juvenile Astrocytoma

Search GEO for disease gene expression data for Juvenile Astrocytoma.

Pathways for Juvenile Astrocytoma

Pathways related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 EXT1 XYLT1

GO Terms for Juvenile Astrocytoma

Cellular components related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.13 CALR SDC4 YWHAE
2 cytoplasmic stress granule GO:0010494 8.62 DDX3X ELAVL1

Biological processes related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of translation GO:0017148 9.37 CALR DDX3X
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.32 DDX3X YWHAE
3 positive regulation of translation GO:0045727 9.26 DDX3X ELAVL1
4 glycosaminoglycan metabolic process GO:0030203 9.16 SDC4 XYLT1
5 heparan sulfate proteoglycan biosynthetic process GO:0015012 8.96 EXT1 XYLT1
6 glycosaminoglycan biosynthetic process GO:0006024 8.8 EXT1 SDC4 XYLT1

Molecular functions related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetylglucosaminyltransferase activity GO:0008375 8.62 EXT1 XYLT1

Sources for Juvenile Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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