MCID: JVN011
MIFTS: 26

Juvenile Dermatitis Herpetiformis

Categories: Genetic diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Juvenile Dermatitis Herpetiformis

MalaCards integrated aliases for Juvenile Dermatitis Herpetiformis:

Name: Juvenile Dermatitis Herpetiformis 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8507
ICD9CM 36 694.2
SNOMED-CT 69 5906000
ICD10 34 L12.2
UMLS 74 C0152092

Summaries for Juvenile Dermatitis Herpetiformis

MalaCards based summary : Juvenile Dermatitis Herpetiformis is related to dermatitis herpetiformis, familial and dermatitis. An important gene associated with Juvenile Dermatitis Herpetiformis is GLS2 (Glutaminase 2), and among its related pathways/superpathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Affiliated tissues include skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Dermatitis Herpetiformis

Graphical network of the top 20 diseases related to Juvenile Dermatitis Herpetiformis:



Diseases related to Juvenile Dermatitis Herpetiformis

Symptoms & Phenotypes for Juvenile Dermatitis Herpetiformis

GenomeRNAi Phenotypes related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

27 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.11 HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.11 C4A C4B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.11 HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.11 C4A C4B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.11 C4A C4B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.11 HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.11 GLS2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.11 GLS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.11 C4A C4B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.11 HLA-A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.11 C4A C4B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.11 HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.11 C4A C4B HLA-A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.11 HLA-A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-4 10.11 GLS2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.11 C4A C4B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.11 GLS2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.11 C4A C4B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.11 GLS2 HLA-A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.11 GLS2 HLA-A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.11 C4A C4B
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.11 GLS2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.11 GLS2

Drugs & Therapeutics for Juvenile Dermatitis Herpetiformis

Search Clinical Trials , NIH Clinical Center for Juvenile Dermatitis Herpetiformis

Genetic Tests for Juvenile Dermatitis Herpetiformis

Anatomical Context for Juvenile Dermatitis Herpetiformis

MalaCards organs/tissues related to Juvenile Dermatitis Herpetiformis:

42
Skin

Publications for Juvenile Dermatitis Herpetiformis

Articles related to Juvenile Dermatitis Herpetiformis:

(show all 15)
# Title Authors Year
1
Immunoglobulin and HLA-DP genes contribute to the susceptibility to juvenile dermatitis herpetiformis. ( 1627534 )
1992
2
HLA in juvenile dermatitis herpetiformis: clinical heterogeneity correlated with DNA and serological polymorphism. ( 1979987 )
1990
3
HLA antigens in juvenile dermatitis herpetiformis. ( 6167108 )
1981
4
Juvenile dermatitis herpetiformis. ( 375840 )
1979
5
Juvenile dermatitis herpetiformis: an immunoelectron microscopic study. ( 389268 )
1979
6
Juvenile dermatitis herpetiformis and chronic acquired bullous disease in children. ( 367643 )
1978
7
Juvenile dermatitis herpetiformis: an immunologically proven case. ( 865949 )
1977
8
Juvenile dermatitis herpetiformis versus "benign chronic bullous dermatosis of childhood." Are these immunologic diseases? ( 1104719 )
1975
9
Juvenile dermatitis herpetiformis (a case report). ( 4777767 )
1973
10
Juvenile dermatitis herpetiformis in Jamaica: clinical and gastrointestinal features. ( 5018677 )
1972
11
Juvenile dermatitis herpetiformis. ( 5087210 )
1972
12
Juvenile dermatitis herpetiformis in the light of immunofluorescence studies. ( 4942237 )
1971
13
Juvenile dermatitis herpetiformis. ( 5715707 )
1968
14
Juvenile dermatitis herpetiformis. Case reports of six children from Birmingham. ( 6024738 )
1967
15
Epidermolysis bullosa resembling juvenile dermatitis herpetiformis. ( 13149726 )
1954

Variations for Juvenile Dermatitis Herpetiformis

Expression for Juvenile Dermatitis Herpetiformis

Search GEO for disease gene expression data for Juvenile Dermatitis Herpetiformis.

Pathways for Juvenile Dermatitis Herpetiformis

GO Terms for Juvenile Dermatitis Herpetiformis

Cellular components related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.16 C4A C4B
2 dendrite GO:0030425 9.13 ADCY10 C4A C4B
3 axon GO:0030424 8.8 ADCY10 C4A C4B

Biological processes related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 9.37 C4A C4B
2 immune system process GO:0002376 9.33 C4A C4B HLA-A
3 negative regulation of endopeptidase activity GO:0010951 9.32 C4A C4B
4 regulation of complement activation GO:0030449 9.26 C4A C4B
5 complement activation GO:0006956 8.96 C4A C4B
6 positive regulation of apoptotic cell clearance GO:2000427 8.62 C4A C4B

Molecular functions related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C4A C4B

Sources for Juvenile Dermatitis Herpetiformis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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