MCID: JVN011
MIFTS: 27

Juvenile Dermatitis Herpetiformis

Categories: Immune diseases, Skin diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Juvenile Dermatitis Herpetiformis

MalaCards integrated aliases for Juvenile Dermatitis Herpetiformis:

Name: Juvenile Dermatitis Herpetiformis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8507
ICD10 33 L12.2
ICD9CM 35 694.2
UMLS 73 C0152092

Summaries for Juvenile Dermatitis Herpetiformis

MalaCards based summary : Juvenile Dermatitis Herpetiformis is related to dermatitis herpetiformis, familial and dermatitis. An important gene associated with Juvenile Dermatitis Herpetiformis is GLS2 (Glutaminase 2), and among its related pathways/superpathways are Complement Pathway and Pertussis. Affiliated tissues include skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Dermatitis Herpetiformis

Diseases in the Dermatitis Herpetiformis family:

Dermatitis Herpetiformis, Familial Juvenile Dermatitis Herpetiformis

Diseases related to Juvenile Dermatitis Herpetiformis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 dermatitis herpetiformis, familial 10.5
2 dermatitis 10.5
3 dermatitis herpetiformis 10.5
4 haemophilus meningitis 10.3 HLA-A TNFRSF25
5 malignant essential hypertension 10.3 HLA-A TNFRSF25
6 sclerosing keratitis 10.2 CD79A GLS2
7 anterior scleritis 10.1 CD79A GLS2
8 periodontosis 10.0 CD79A HLA-A
9 byssinosis 10.0 CD79A HLA-A
10 autoimmune disease of skin and connective tissue 10.0 CD79A TNFRSF25
11 cholangitis, primary sclerosing 10.0 HLA-A TNFRSF25
12 thymic dysplasia 10.0 CD79A HLA-A
13 geographic tongue 10.0 CD79A HLA-A
14 epidermolysis bullosa 9.9
15 autoimmune disease of gastrointestinal tract 9.9 CD79A TNFRSF25
16 herpes gestationis 9.8 C4A TNFRSF25
17 hypersensitivity reaction disease 9.8 CD79A TNFRSF25
18 immunodeficiency due to a classical component pathway complement deficiency 9.8 C4A C4B
19 epilepsy, familial temporal lobe, 2 9.7 C4A C4B
20 pediatric systemic lupus erythematosus 9.7 C4A C4B
21 celiac disease 1 9.6 CD79A HLA-A TNFRSF25
22 hypersensitivity vasculitis 9.6 C4A CD79A
23 immune system disease 9.5 CD79A TNFRSF25
24 membranoproliferative glomerulonephritis 9.4 C4A CD79A
25 cholera 9.2 ADCY10 CD79A
26 iga glomerulonephritis 9.2 C4A CD79A
27 immunoglobulin alpha deficiency 9.1 C4A CD79A TNFRSF25
28 behcet syndrome 9.1 C4A CD79A HLA-A
29 hypersensitivity reaction type iii disease 9.1 C4A C4B CD79A
30 indeterminate leprosy 9.1 C4A C4B CD79A
31 glomerulonephritis 9.0 C4A C4B CD79A
32 diabetes mellitus, insulin-dependent 8.6 C4A CD79A HLA-A TNFRSF25

Graphical network of the top 20 diseases related to Juvenile Dermatitis Herpetiformis:



Diseases related to Juvenile Dermatitis Herpetiformis

Symptoms & Phenotypes for Juvenile Dermatitis Herpetiformis

GenomeRNAi Phenotypes related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

26 (show all 26)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.18 HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.18 C4A C4B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.18 CD79A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.18 HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.18 C4A C4B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.18 C4A C4B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.18 HLA-A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.18 GLS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.18 GLS2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.18 C4A C4B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.18 HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.18 C4A C4B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.18 CD79A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.18 HLA-A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.18 HLA-A C4A C4B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.18 HLA-A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-4 10.18 GLS2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.18 C4A C4B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.18 GLS2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.18 CD79A C4A C4B
21 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.18 GLS2 HLA-A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.18 CD79A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.18 CD79A GLS2 HLA-A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.18 C4A C4B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.18 GLS2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.18 GLS2

Drugs & Therapeutics for Juvenile Dermatitis Herpetiformis

Search Clinical Trials , NIH Clinical Center for Juvenile Dermatitis Herpetiformis

Genetic Tests for Juvenile Dermatitis Herpetiformis

Anatomical Context for Juvenile Dermatitis Herpetiformis

MalaCards organs/tissues related to Juvenile Dermatitis Herpetiformis:

41
Skin

Publications for Juvenile Dermatitis Herpetiformis

Articles related to Juvenile Dermatitis Herpetiformis:

(show all 15)
# Title Authors Year
1
Immunoglobulin and HLA-DP genes contribute to the susceptibility to juvenile dermatitis herpetiformis. ( 1627534 )
1992
2
HLA in juvenile dermatitis herpetiformis: clinical heterogeneity correlated with DNA and serological polymorphism. ( 1979987 )
1990
3
HLA antigens in juvenile dermatitis herpetiformis. ( 6167108 )
1981
4
Juvenile dermatitis herpetiformis. ( 375840 )
1979
5
Juvenile dermatitis herpetiformis: an immunoelectron microscopic study. ( 389268 )
1979
6
Juvenile dermatitis herpetiformis and chronic acquired bullous disease in children. ( 367643 )
1978
7
Juvenile dermatitis herpetiformis: an immunologically proven case. ( 865949 )
1977
8
Juvenile dermatitis herpetiformis versus "benign chronic bullous dermatosis of childhood." Are these immunologic diseases? ( 1104719 )
1975
9
Juvenile dermatitis herpetiformis (a case report). ( 4777767 )
1973
10
Juvenile dermatitis herpetiformis in Jamaica: clinical and gastrointestinal features. ( 5018677 )
1972
11
Juvenile dermatitis herpetiformis. ( 5087210 )
1972
12
Juvenile dermatitis herpetiformis in the light of immunofluorescence studies. ( 4942237 )
1971
13
Juvenile dermatitis herpetiformis. ( 5715707 )
1968
14
Juvenile dermatitis herpetiformis. Case reports of six children from Birmingham. ( 6024738 )
1967
15
Epidermolysis bullosa resembling juvenile dermatitis herpetiformis. ( 13149726 )
1954

Variations for Juvenile Dermatitis Herpetiformis

Expression for Juvenile Dermatitis Herpetiformis

Search GEO for disease gene expression data for Juvenile Dermatitis Herpetiformis.

Pathways for Juvenile Dermatitis Herpetiformis

Pathways related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.18 C4A C4B
2 10.84 C4A C4B
3 10.37 C4A C4B

GO Terms for Juvenile Dermatitis Herpetiformis

Cellular components related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.63 ADCY10 C4A C4B CD79A HLA-A TNFRSF25
2 dendrite GO:0030425 9.13 ADCY10 C4A C4B
3 axon GO:0030424 8.8 ADCY10 C4A C4B

Biological processes related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.33 C4A C4B TNFRSF25
2 regulation of complement activation GO:0030449 9.32 C4A C4B
3 complement activation GO:0006956 9.26 C4A C4B
4 immune system process GO:0002376 9.26 C4A C4B CD79A HLA-A
5 positive regulation of apoptotic cell clearance GO:2000427 8.62 C4A C4B

Molecular functions related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C4A C4B

Sources for Juvenile Dermatitis Herpetiformis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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