MCID: JVN011
MIFTS: 24

Juvenile Dermatitis Herpetiformis

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Juvenile Dermatitis Herpetiformis

MalaCards integrated aliases for Juvenile Dermatitis Herpetiformis:

Name: Juvenile Dermatitis Herpetiformis 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:8507
ICD9CM 34 694.2
SNOMED-CT 67 267799009
ICD10 32 L12.2
UMLS 70 C0152092

Summaries for Juvenile Dermatitis Herpetiformis

MalaCards based summary : Juvenile Dermatitis Herpetiformis is related to dermatitis herpetiformis, familial and dermatitis herpetiformis. An important gene associated with Juvenile Dermatitis Herpetiformis is GLS2 (Glutaminase 2), and among its related pathways/superpathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Affiliated tissues include temporal lobe, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Dermatitis Herpetiformis

Diseases in the Dermatitis Herpetiformis family:

Dermatitis Herpetiformis, Familial Juvenile Dermatitis Herpetiformis

Diseases related to Juvenile Dermatitis Herpetiformis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 dermatitis herpetiformis, familial 10.7
2 dermatitis herpetiformis 10.7
3 dermatitis 10.4
4 pemphigoid 10.2
5 bullous pemphigoid 10.2
6 epidermolysis bullosa simplex, dowling-meara type 10.0
7 rheumatic fever-related antigen 10.0
8 rheumatic fever 10.0
9 epidermolysis bullosa 10.0
10 selective igg deficiency disease 10.0 TNFRSF25 HLA-A
11 haemophilus meningitis 10.0 TNFRSF25 HLA-A
12 immunoglobulin alpha deficiency 10.0 TNFRSF25 C4A
13 immunodeficiency due to a classical component pathway complement deficiency 9.8 C4B C4A
14 complement deficiency 9.8 C4B C4A
15 louse-borne relapsing fever 9.8 C4B C4A
16 cholangitis, primary sclerosing 9.8 TNFRSF25 HLA-A
17 relapsing fever 9.8 C4B C4A
18 tick-borne relapsing fever 9.8 C4B C4A
19 complement factor i deficiency 9.8 C4B C4A
20 pediatric systemic lupus erythematosus 9.8 C4B C4A
21 monkeypox 9.8 C4B C4A
22 epilepsy, familial temporal lobe, 2 9.8 C4B C4A
23 complement component 3 deficiency 9.8 C4B C4A
24 felty syndrome 9.8 C4B C4A
25 complement component 5 deficiency 9.8 C4B C4A
26 hypersensitivity vasculitis 9.8 C4B C4A
27 complement component 2 deficiency 9.8 C4B C4A
28 hypersensitivity reaction type iii disease 9.8 C4B C4A
29 3mc syndrome 9.7 C4B C4A
30 blood protein disease 9.7 C4B C4A
31 hereditary angioedema 9.7 C4B C4A
32 angioedema 9.7 C4B C4A
33 type 1 diabetes mellitus 9.7 TNFRSF25 HLA-A C4A
34 hemolytic uremic syndrome, atypical 1 9.6 C4B C4A
35 hemorrhagic disease 9.5 TNFRSF25 C4B C4A
36 blood coagulation disease 9.5 C4B C4A

Graphical network of the top 20 diseases related to Juvenile Dermatitis Herpetiformis:



Diseases related to Juvenile Dermatitis Herpetiformis

Symptoms & Phenotypes for Juvenile Dermatitis Herpetiformis

GenomeRNAi Phenotypes related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.4 C4A C4B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.4 HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.4 C4A C4B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.4 C4A C4B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 C4A C4B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.4 C4A C4B

Drugs & Therapeutics for Juvenile Dermatitis Herpetiformis

Search Clinical Trials , NIH Clinical Center for Juvenile Dermatitis Herpetiformis

Genetic Tests for Juvenile Dermatitis Herpetiformis

Anatomical Context for Juvenile Dermatitis Herpetiformis

MalaCards organs/tissues related to Juvenile Dermatitis Herpetiformis:

40
Temporal Lobe

Publications for Juvenile Dermatitis Herpetiformis

Articles related to Juvenile Dermatitis Herpetiformis:

(show all 19)
# Title Authors PMID Year
1
Immunoglobulin and HLA-DP genes contribute to the susceptibility to juvenile dermatitis herpetiformis. 61
1627534 1992
2
HLA in juvenile dermatitis herpetiformis: clinical heterogeneity correlated with DNA and serological polymorphism. 61
1979987 1990
3
[HLA antigens and morphology of the small intestinal mucosa in Duhring's juvenile dermatitis herpetiformis]. 61
4022623 1985
4
Epidermolysis bullosa herpetiformis Dowling-Meara. Report of a case and pathomorphogenesis. 61
7084543 1982
5
HLA antigens in juvenile dermatitis herpetiformis. 61
6167108 1981
6
[Association between HLA antigens and juvenile dermatitis herpetiformis]. 61
6171469 1980
7
Juvenile dermatitis herpetiformis: an immunoelectron microscopic study. 61
389268 1979
8
Juvenile dermatitis herpetiformis. 61
375840 1979
9
Juvenile dermatitis herpetiformis and chronic acquired bullous disease in children. 61
367643 1978
10
[On the immunopathologic findings in a case of juvenile dermatitis herpetiformis with rheumatic fever (author's transl)]. 61
306464 1978
11
Juvenile dermatitis herpetiformis: an immunologically proven case. 61
865949 1977
12
Juvenile dermatitis herpetiformis versus "benign chronic bullous dermatosis of childhood." Are these immunologic diseases? 61
1104719 1975
13
Juvenile dermatitis herpetiformis (a case report). 61
4777767 1973
14
Juvenile dermatitis herpetiformis. 61
5087210 1972
15
Juvenile dermatitis herpetiformis in Jamaica: clinical and gastrointestinal features. 61
5018677 1972
16
Juvenile dermatitis herpetiformis in the light of immunofluorescence studies. 61
4942237 1971
17
Juvenile dermatitis herpetiformis. 61
5715707 1968
18
Juvenile dermatitis herpetiformis. Case reports of six children from Birmingham. 61
6024738 1967
19
Epidermolysis bullosa resembling juvenile dermatitis herpetiformis. 61
13149726 1954

Variations for Juvenile Dermatitis Herpetiformis

Expression for Juvenile Dermatitis Herpetiformis

Search GEO for disease gene expression data for Juvenile Dermatitis Herpetiformis.

Pathways for Juvenile Dermatitis Herpetiformis

Pathways related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.48 C4B C4A
2 11.42 C4B C4A
3 11.14 C4B C4A
4
Show member pathways
10.86 C4B C4A
5 10.5 C4B C4A

GO Terms for Juvenile Dermatitis Herpetiformis

Cellular components related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.13 C4B C4A ADCY10
2 axon GO:0030424 8.8 C4B C4A ADCY10

Biological processes related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.33 HLA-A C4B C4A
2 regulation of complement activation GO:0030449 9.26 C4B C4A
3 complement activation GO:0006956 8.96 C4B C4A
4 positive regulation of apoptotic cell clearance GO:2000427 8.62 C4B C4A

Molecular functions related to Juvenile Dermatitis Herpetiformis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C4B C4A

Sources for Juvenile Dermatitis Herpetiformis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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