JIIM
MCID: JVN060
MIFTS: 18

Juvenile Idiopathic Inflammatory Myopathy (JIIM)

Categories: Bone diseases, Genetic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Juvenile Idiopathic Inflammatory Myopathy

MalaCards integrated aliases for Juvenile Idiopathic Inflammatory Myopathy:

Name: Juvenile Idiopathic Inflammatory Myopathy 59
Jiim 59

Classifications:



External Ids:

Orphanet 59 ORPHA329888

Summaries for Juvenile Idiopathic Inflammatory Myopathy

MalaCards based summary : Juvenile Idiopathic Inflammatory Myopathy, also known as jiim, is related to juvenile polymyositis and myopathy. An important gene associated with Juvenile Idiopathic Inflammatory Myopathy is LMNA (Lamin A/C). The drugs rituximab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include bone and testes.

Related Diseases for Juvenile Idiopathic Inflammatory Myopathy

Diseases in the Idiopathic Inflammatory Myopathy family:

Juvenile Idiopathic Inflammatory Myopathy

Diseases related to Juvenile Idiopathic Inflammatory Myopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 juvenile polymyositis 11.8
2 myopathy 10.8
3 myositis 10.7
4 dermatomyositis 10.6
5 idiopathic inflammatory myopathy 10.6
6 childhood type dermatomyositis 10.5
7 rheumatic disease 10.4
8 enthesopathy 10.4
9 exanthem 10.4
10 polymyositis 10.4
11 interstitial lung disease 10.3
12 raynaud phenomenon 10.2
13 overlap myositis 10.2
14 autoimmune disease 10.1
15 scleroderma, familial progressive 10.1
16 skin disease 10.1
17 connective tissue disease 10.1
18 lung disease 10.1
19 muscular dystrophy 10.1
20 carpal tunnel syndrome 10.0
21 inclusion body myositis 10.0
22 poikiloderma with neutropenia 10.0
23 systemic lupus erythematosus 2 10.0
24 adult dermatomyositis 10.0
25 calcinosis 10.0
26 synovitis 10.0
27 dyskeratosis congenita 10.0
28 congestive heart failure 10.0
29 myocarditis 10.0
30 homologous wasting disease 10.0
31 leukoplakia 10.0
32 juvenile overlap myositis 10.0
33 overgrowth syndrome 10.0
34 skeletal muscle disease 10.0

Graphical network of the top 20 diseases related to Juvenile Idiopathic Inflammatory Myopathy:



Diseases related to Juvenile Idiopathic Inflammatory Myopathy

Symptoms & Phenotypes for Juvenile Idiopathic Inflammatory Myopathy

Drugs & Therapeutics for Juvenile Idiopathic Inflammatory Myopathy

Drugs for Juvenile Idiopathic Inflammatory Myopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 2 174722-31-7 10201696
2 Immunologic Factors Phase 2
3 Antineoplastic Agents, Immunological Phase 2
4 Antirheumatic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rituximab Therapy in Refractory Adult and Juvenile Idiopathic Inflammatory Myopathy (IIM) Completed NCT00106184 Phase 2 Rituximab;Placebo

Search NIH Clinical Center for Juvenile Idiopathic Inflammatory Myopathy

Genetic Tests for Juvenile Idiopathic Inflammatory Myopathy

Anatomical Context for Juvenile Idiopathic Inflammatory Myopathy

MalaCards organs/tissues related to Juvenile Idiopathic Inflammatory Myopathy:

41
Bone, Testes

Publications for Juvenile Idiopathic Inflammatory Myopathy

Articles related to Juvenile Idiopathic Inflammatory Myopathy:

(show all 34)
# Title Authors PMID Year
1
Histological heterogeneity in a large clinical cohort of juvenile idiopathic inflammatory myopathy: analysis by myositis autoantibody and pathological features. 38
30378704 2019
2
Long-term outcomes in Juvenile Myositis patients. 38
31303436 2019
3
Juvenile idiopathic inflammatory myopathies: A clinicopathological study with emphasis on muscle histology. 38
30706861 2019
4
A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy. 38
31001260 2019
5
Juvenile Idiopathic Inflammatory Myopathies. 38
30031496 2018
6
Comparing the importance of quality measurement themes in juvenile idiopathic inflammatory myositis between patients and families and healthcare professionals. 38
29673367 2018
7
Effect of Adalimumab on Refractory Arthritis in Juvenile Idiopathic Inflammatory Myopathy with Anti-MDA5 Autoantibody. 38
29552370 2018
8
Effective induction therapy for anti-SRP associated myositis in childhood: A small case series and review of the literature. 38
29089059 2017
9
Monitoring change in volume of calcifications in juvenile idiopathic inflammatory myopathy: a pilot study using low dose computed tomography. 38
27894310 2016
10
The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes. 38
27028907 2016
11
Subcutaneous Immunoglobulin in Refractory Juvenile Dermatomyositis. 38
26966131 2016
12
Juvenile Idiopathic Inflammatory Myopathy in a Patient With Dyskeratosis Congenita Due to C16orf57 Mutation. 38
26535771 2016
13
Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy. 38
26338728 2015
14
Efficacy of ultrasound elastography in detecting active myositis in children: can it replace MRI? 38
25903842 2015
15
Infantile-onset LMNA-associated Muscular Dystrophy Mimicking Juvenile Idiopathic Inflammatory Myopathy. 38
26034236 2015
16
Recent advances in juvenile idiopathic inflammatory myopathies. 38
25160931 2014
17
Developments in the classification and treatment of the juvenile idiopathic inflammatory myopathies. 38
24182859 2013
18
An update on inflammatory myositis in children. 38
23912317 2013
19
The myositis autoantibody phenotypes of the juvenile idiopathic inflammatory myopathies. 38
23877355 2013
20
The clinical phenotypes of the juvenile idiopathic inflammatory myopathies. 38
23263716 2013
21
Environmental factors preceding illness onset differ in phenotypes of the juvenile idiopathic inflammatory myopathies. 38
20802007 2010
22
Update on the assessment of children with juvenile idiopathic inflammatory myopathy. 38
20425522 2010
23
HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy. 38
19690132 2009
24
The Cutaneous Assessment Tool: development and reliability in juvenile idiopathic inflammatory myopathy. 38
17890275 2007
25
Intra-rater and inter-rater reliability of the 10-point Manual Muscle Test (MMT) of strength in children with juvenile idiopathic inflammatory myopathies (JIIM). 38
16966313 2006
26
Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies. 38
16082628 2005
27
Anaerobic exercise capacity in patients with juvenile-onset idiopathic inflammatory myopathies. 38
15818720 2005
28
Validation and clinical significance of the Childhood Myositis Assessment Scale for assessment of muscle function in the juvenile idiopathic inflammatory myopathies. 38
15146430 2004
29
Persistent maternally derived peripheral microchimerism is associated with the juvenile idiopathic inflammatory myopathies. 38
11709612 2001
30
Validation of the Childhood Health Assessment Questionnaire in the juvenile idiopathic myopathies. Juvenile Dermatomyositis Disease Activity Collaborative Study Group. 38
11361197 2001
31
Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies. Childhood Myositis Heterogeneity Collaborative Group. 38
11191545 2000
32
Polymorphisms in the IL-1 receptor antagonist gene VNTR are possible risk factors for juvenile idiopathic inflammatory myopathies. 38
10886238 2000
33
Juvenile idiopathic inflammatory myopathies: the value of magnetic resonance imaging in the detection of muscle involvement. 38
10772694 2000
34
Juvenile idiopathic inflammatory myopathy: exercise-induced changes in muscle at short inversion time inversion-recovery MR imaging. 38
9769831 1998

Variations for Juvenile Idiopathic Inflammatory Myopathy

Expression for Juvenile Idiopathic Inflammatory Myopathy

Search GEO for disease gene expression data for Juvenile Idiopathic Inflammatory Myopathy.

Pathways for Juvenile Idiopathic Inflammatory Myopathy

GO Terms for Juvenile Idiopathic Inflammatory Myopathy

Sources for Juvenile Idiopathic Inflammatory Myopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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