MCID: JVN038
MIFTS: 34

Juvenile Myasthenia Gravis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Juvenile Myasthenia Gravis

MalaCards integrated aliases for Juvenile Myasthenia Gravis:

Name: Juvenile Myasthenia Gravis 60
Juvenile Autoimmune Myasthenia Gravis 60
Juvenile Acquired Myasthenia 60
Childhood Myasthenia Gravis 60

Characteristics:

Orphanet epidemiological data:

60
juvenile myasthenia gravis
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:



External Ids:

ICD10 via Orphanet 35 G70.0
Orphanet 60 ORPHA391497

Summaries for Juvenile Myasthenia Gravis

MalaCards based summary : Juvenile Myasthenia Gravis, also known as juvenile autoimmune myasthenia gravis, is related to systemic lupus erythematosus and myasthenia gravis. An important gene associated with Juvenile Myasthenia Gravis is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include eye, bone and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Myasthenia Gravis

Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Juvenile Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 29.1 HLA-DRB1 IL10 TGFB1
2 myasthenia gravis 10.9
3 myasthenia gravis congenital 10.9
4 ptosis 10.1
5 inflammatory bowel disease 10.0 IL10 TGFB1
6 inflammatory bowel disease 25, autosomal recessive 10.0 IL10 TGFB1
7 clonorchiasis 10.0 IL10 TGFB1
8 tuberculoid leprosy 10.0 IL10 TGFB1
9 autoimmune gastritis 10.0 IL10 TGFB1
10 chronic active epstein-barr virus infection 10.0 IL10 TGFB1
11 paranasal sinus disease 10.0 IL10 TGFB1
12 prostatitis 10.0 IL10 TGFB1
13 congenital ptosis 10.0
14 suppression amblyopia 10.0
15 amblyopia 10.0
16 lupus erythematosus 10.0
17 ureteral obstruction 10.0 IL10 TGFB1
18 chronic fatigue syndrome 9.9 IL10 TGFB1
19 anemia, autoimmune hemolytic 9.9
20 hemolytic anemia 9.9
21 eosinophilia-myalgia syndrome 9.9 HLA-DRB1 TGFB1
22 chagas disease 9.9 IL10 TGFB1
23 osteonecrosis of the jaw 9.9 HLA-DRB1 TGFB1
24 oligoarticular juvenile idiopathic arthritis 9.9 HLA-DRB1 TGFB1
25 ocular cicatricial pemphigoid 9.9 HLA-DRB1 TGFB1
26 respiratory system disease 9.9 IL10 TGFB1
27 discoid lupus erythematosus 9.9 HLA-DRB1 IL10
28 cystic echinococcosis 9.9 HLA-DRB1 IL10
29 echinococcosis 9.9 HLA-DRB1 IL10
30 peanut allergy 9.9 HLA-DRB1 IL10
31 hemorrhagic fever 9.9 HLA-DRB1 IL10
32 interstitial lung disease 9.9 IL10 TGFB1
33 acute disseminated encephalomyelitis 9.8 HLA-DRB1 IL10
34 panuveitis 9.8 HLA-DRB1 IL10
35 polyradiculoneuropathy 9.8 HLA-DRB1 IL10
36 autoimmune pancreatitis 9.8 HLA-DRB1 IL10
37 rheumatic fever 9.8 HLA-DRB1 IL10
38 mixed connective tissue disease 9.8 HLA-DRB1 IL10
39 lung disease 9.8 IL10 TGFB1
40 connective tissue disease 9.8 HLA-DRB1 IL10
41 primary progressive multiple sclerosis 9.8 HLA-DRB1 IL10
42 dengue hemorrhagic fever 9.8 HLA-DRB1 IL10
43 vogt-koyanagi-harada disease 9.8 HLA-DRB1 IL10
44 autoimmune disease of central nervous system 9.8 HLA-DRB1 IL10
45 autoimmune disease 9.8 HLA-DRB1 IL10
46 rubella 9.8 HLA-DRB1 IL10
47 bone inflammation disease 9.8 HLA-DRB1 IL10
48 graft-versus-host disease 9.8 HLA-DRB1 IL10
49 pulmonary tuberculosis 9.7 HLA-DRB1 IL10
50 aging 9.7 IL10 TGFB1

Graphical network of the top 20 diseases related to Juvenile Myasthenia Gravis:



Diseases related to Juvenile Myasthenia Gravis

Symptoms & Phenotypes for Juvenile Myasthenia Gravis

GenomeRNAi Phenotypes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

27 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.21 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.21 TGFB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.21 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.21 TGFB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.21 HLA-DRB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.21 TGFB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.21 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.21 IL10 HLA-DRB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.21 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.21 HLA-DRB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.21 TGFB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.21 TGFB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.21 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.21 TGFB1 HLA-DRB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.21 HLA-DRB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.21 TGFB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.21 HLA-DRB1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.21 HLA-DRB1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.21 IL10 TGFB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.21 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.21 IL10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.21 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.21 TGFB1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.21 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.21 TGFB1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.21 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.21 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-77 10.21 TGFB1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.21 IL10 HLA-DRB1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.21 IL10
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.21 IL10
33 Decreased viability with paclitaxel GR00179-A-1 9.13 IL10 TGFB1
34 Decreased viability with paclitaxel GR00179-A-3 9.13 TGFB1

Drugs & Therapeutics for Juvenile Myasthenia Gravis

Search Clinical Trials , NIH Clinical Center for Juvenile Myasthenia Gravis

Genetic Tests for Juvenile Myasthenia Gravis

Anatomical Context for Juvenile Myasthenia Gravis

MalaCards organs/tissues related to Juvenile Myasthenia Gravis:

42
Eye, Bone, Testes, Thymus

Publications for Juvenile Myasthenia Gravis

Articles related to Juvenile Myasthenia Gravis:

(show top 50) (show all 73)
# Title Authors Year
1
Thoracoscopic thymectomy for juvenile myasthenia gravis. ( 30729982 )
2019
2
Clinical Characteristics of Juvenile Myasthenia Gravis in Southern China. ( 29535672 )
2018
3
Serial Stimulated Jitter Analysis In Juvenile Myasthenia Gravis. ( 30106469 )
2018
4
Juvenile myasthenia gravis in Norway: Clinical characteristics, treatment, and long-term outcome in a nationwide population-based cohort. ( 28457757 )
2017
5
Early onset bilateral juvenile myasthenia gravis masquerading as simple congenital ptosis. ( 28293536 )
2017
6
The role of thymectomy in the treatment of juvenile myasthenia gravis: a systematic review. ( 28401300 )
2017
7
Outcome after Robotic-Assisted Thymectomy in Children and Adolescents with Acetylcholine Receptor Antibody-Positive Juvenile Myasthenia Gravis. ( 28628938 )
2017
8
Juvenile myasthenia gravis. ( 28784230 )
2017
9
Clinical features and evolution of juvenile myasthenia gravis in a French cohort. ( 28877546 )
2017
10
Juvenile myasthenia gravis in Norway: HLA-DRB1*04:04 is positively associated with prepubertal onset. ( 29036181 )
2017
11
Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age. ( 27581849 )
2016
12
Outcomes of thoracoscopic thymectomy in patients with juvenile myasthenia gravis. ( 26831531 )
2016
13
The African-387 C>T TGFB1 variant is functional and associates with the ophthalmoplegic complication in juvenile myasthenia gravis. ( 26632886 )
2016
14
Juvenile myasthenia gravis in Norway: A nationwide epidemiological study. ( 27666466 )
2016
15
Multidisciplinary treatment for prepubertal juvenile myasthenia gravis with crisis. ( 27324449 )
2016
16
Co-existence of juvenile-onset systemic lupus erythematosus and juvenile myasthenia gravis. ( 26085593 )
2015
17
Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis. ( 25780436 )
2015
18
Results of surgical treatment for juvenile myasthenia gravis. ( 26585984 )
2015
19
Sevoflurane and thoracic epidural anesthesia for trans-sternal thymectomy in a child with juvenile myasthenia gravis. ( 24803774 )
2014
20
Outcome of children with acetylcholine receptor (AChR) antibody positive juvenile myasthenia gravis following thymectomy. ( 24239058 )
2014
21
Comparison of plasmapheresis and intravenous immunoglobulin as maintenance therapies for juvenile myasthenia gravis. ( 24590389 )
2014
22
Juvenile myasthenia gravis: recommendations for diagnostic approaches and treatment. ( 24470240 )
2014
23
Juvenile myasthenia gravis: a twenty-year experience. ( 23492460 )
2013
24
Clinical outcome of juvenile myasthenia gravis after extended transsternal thymectomy in a chinese cohort. ( 23374447 )
2013
25
Efficacy and safety of thoracoscopic thymectomy in the treatment of juvenile myasthenia gravis. ( 23423693 )
2013
26
The effect of steroid treatment and thymectomy on bone age and height development in juvenile myasthenia gravis. ( 23619530 )
2013
27
Update on juvenile myasthenia gravis. ( 24141560 )
2013
28
Management of juvenile myasthenia gravis. ( 23337001 )
2013
29
Rituximab in severe seronegative juvenile myasthenia gravis: review of the literature. ( 22883288 )
2012
30
The characteristics of juvenile myasthenia gravis among South Africans. ( 22668957 )
2012
31
Juvenile myasthenia gravis: a paediatric perspective. ( 22110902 )
2011
32
Hybrid combination of small subxiphoid incision and thoracoscopic thymectomy for juvenile myasthenia gravis. ( 21496556 )
2011
33
Thymectomy for inducing remission in juvenile myasthenia gravis. ( 21243366 )
2011
34
Childhood myasthenia gravis: clinical features and outcomes. ( 22043769 )
2011
35
Anesthesia for patients undergoing transsternal thymectomy for juvenile myasthenia gravis. ( 21655012 )
2011
36
Juvenile myasthenia gravis: three case reports and a literature review. ( 19406758 )
2009
37
Juvenile myasthenia gravis. ( 19229875 )
2009
38
Ptosis and cranial nerve IV palsy reveal juvenile myasthenia gravis. ( 19545846 )
2009
39
Long-term clinical outcome after extended thymectomy combined postoperative high-dose steroid therapy for juvenile myasthenia gravis. ( 18414352 )
2008
40
High interleukin-10 production is associated with anti-acetylcholine receptor antibody production and treatment response in juvenile myasthenia gravis. ( 17917921 )
2007
41
A combination of total intravenous anesthesia and thoracic epidural for thymectomy in juvenile myasthenia gravis. ( 17359407 )
2007
42
Juvenile myasthenia gravis mimicking recurrent VI nerve palsy of childhood. ( 14709527 )
2004
43
Antibodies against muscle-specific kinase in juvenile myasthenia gravis. ( 12776235 )
2003
44
[Thymectomy in juvenile myasthenia gravis]. ( 12221621 )
2002
45
Thoracoscopic thymectomy for juvenile myasthenia gravis. ( 12522275 )
2002
46
Foreign body aspiration: a presenting sign of juvenile myasthenia gravis. ( 11506135 )
2001
47
Video-assisted thoracoscopic thymectomy in juvenile myasthenia gravis. ( 11510927 )
2001
48
High-dose intravenous immunoglobulin therapy in juvenile myasthenia gravis. ( 10669204 )
2000
49
Thoracoscopic thymectomy in juvenile myasthenia gravis. ( 10813346 )
2000
50
Juvenile myasthenia gravis: treatment with immune globulin and thymectomy. ( 9492094 )
1998

Variations for Juvenile Myasthenia Gravis

Expression for Juvenile Myasthenia Gravis

Search GEO for disease gene expression data for Juvenile Myasthenia Gravis.

Pathways for Juvenile Myasthenia Gravis

Pathways related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 HLA-DRB1 IL10 TGFB1
2
Show member pathways
12.35 HLA-DRB1 IL10 TGFB1
3
Show member pathways
11.99 IL10 TGFB1
4
Show member pathways
11.97 HLA-DRB1 IL10 TGFB1
5 11.92 HLA-DRB1 TGFB1
6
Show member pathways
11.7 IL10 TGFB1
7
Show member pathways
11.66 IL10 TGFB1
8
Show member pathways
11.6 HLA-DRB1 IL10 TGFB1
9 11.59 IL10 TGFB1
10 11.51 IL10 TGFB1
11 11.47 HLA-DRB1 TGFB1
12 11.38 HLA-DRB1 IL10 TGFB1
13 11.36 IL10 TGFB1
14 11.33 IL10 TGFB1
15 11.29 HLA-DRB1 IL10
16 11.09 IL10 TGFB1
17 11.02 IL10 TGFB1
18 10.77 HLA-DRB1 TGFB1
19 10.26 HLA-DRB1 IL10 TGFB1

GO Terms for Juvenile Myasthenia Gravis

Biological processes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.43 IL10 TGFB1
2 aging GO:0007568 9.4 IL10 TGFB1
3 response to organic substance GO:0010033 9.37 IL10 TGFB1
4 liver regeneration GO:0097421 9.32 IL10 TGFB1
5 negative regulation of mitotic cell cycle GO:0045930 9.26 IL10 TGFB1
6 negative regulation of interferon-gamma production GO:0032689 9.16 HLA-DRB1 IL10
7 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.96 IL10 TGFB1
8 negative regulation of T cell proliferation GO:0042130 8.8 HLA-DRB1 IL10 TGFB1

Molecular functions related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 IL10 TGFB1
2 growth factor activity GO:0008083 8.62 IL10 TGFB1

Sources for Juvenile Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....