MCID: JVN038
MIFTS: 31

Juvenile Myasthenia Gravis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Juvenile Myasthenia Gravis

MalaCards integrated aliases for Juvenile Myasthenia Gravis:

Name: Juvenile Myasthenia Gravis 58
Juvenile Autoimmune Myasthenia Gravis 58
Juvenile Acquired Myasthenia 58
Childhood Myasthenia Gravis 58

Characteristics:

Orphanet epidemiological data:

58
juvenile myasthenia gravis
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 G70.0
Orphanet 58 ORPHA391497

Summaries for Juvenile Myasthenia Gravis

MalaCards based summary : Juvenile Myasthenia Gravis, also known as juvenile autoimmune myasthenia gravis, is related to autoimmune disease and systemic lupus erythematosus. An important gene associated with Juvenile Myasthenia Gravis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include eye, thyroid and thymus, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Juvenile Myasthenia Gravis

Diseases in the Myasthenia Gravis family:

Juvenile Myasthenia Gravis Adult-Onset Myasthenia Gravis

Diseases related to Juvenile Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 autoimmune disease 29.9 TGFB1 IL10 HLA-DRB1
2 systemic lupus erythematosus 29.0 TGFB1 IL10 HLA-DRB1
3 myasthenia gravis 11.0
4 thymoma, familial 10.5
5 ptosis 10.5
6 thymoma 10.5
7 kearns-sayre syndrome 10.2
8 suppression amblyopia 10.2
9 amblyopia 10.2
10 strabismus 10.1
11 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
12 mechanical strabismus 10.1
13 beryllium disease 10.0 TGFB1 HLA-DRB1
14 chronic beryllium disease 10.0 TGFB1 HLA-DRB1
15 osteonecrosis of the jaw 10.0 TGFB1 HLA-DRB1
16 oligoarticular juvenile idiopathic arthritis 10.0 TGFB1 HLA-DRB1
17 idiopathic nephrotic syndrome 10.0 TGFB1 HLA-DRB1
18 eosinophilia-myalgia syndrome 10.0 TGFB1 HLA-DRB1
19 ocular cicatricial pemphigoid 10.0 TGFB1 HLA-DRB1
20 teeth, supernumerary 10.0
21 autoimmune thyroid disease 1 10.0
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
23 cyanosis, transient neonatal 10.0
24 congenital ptosis 10.0
25 alternating exotropia 10.0
26 exotropia 10.0
27 hypothyroidism 10.0
28 congenital myasthenic syndrome 10.0
29 thyroid gland disease 10.0
30 hyperthyroidism 10.0
31 lupus erythematosus 10.0
32 hypertropia 10.0
33 dysphagia 10.0
34 hypotonia 10.0
35 seizure disorder 10.0
36 adult-onset myasthenia gravis 10.0
37 premature aging 10.0
38 myasthenic syndrome, congenital, 6, presynaptic 10.0
39 alport syndrome 9.9 TGFB1 HLA-DRB1
40 chronic active epstein-barr virus infection 9.9 TGFB1 IL10
41 clonorchiasis 9.9 TGFB1 IL10
42 tuberculoid leprosy 9.9 TGFB1 IL10
43 evans' syndrome 9.9 TGFB1 IL10
44 giardiasis 9.9 TGFB1 IL10
45 multidrug-resistant tuberculosis 9.9 TGFB1 IL10
46 inflammatory bowel disease 25, autosomal recessive 9.9 TGFB1 IL10
47 gingival disease 9.9 TGFB1 IL10
48 paranasal sinus disease 9.9 TGFB1 IL10
49 brucellosis 9.9 TGFB1 IL10
50 silicosis 9.9 TGFB1 IL10

Graphical network of the top 20 diseases related to Juvenile Myasthenia Gravis:



Diseases related to Juvenile Myasthenia Gravis

Symptoms & Phenotypes for Juvenile Myasthenia Gravis

GenomeRNAi Phenotypes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.32 HLA-DRB1 IL10
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.32 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.32 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.32 IL10
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 9.32 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.32 IL10
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.32 HLA-DRB1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-80 9.32 HLA-DRB1 IL10

Drugs & Therapeutics for Juvenile Myasthenia Gravis

Search Clinical Trials , NIH Clinical Center for Juvenile Myasthenia Gravis

Genetic Tests for Juvenile Myasthenia Gravis

Anatomical Context for Juvenile Myasthenia Gravis

MalaCards organs/tissues related to Juvenile Myasthenia Gravis:

40
Eye, Thyroid, Thymus, Bone, Heart, Liver, Lung

Publications for Juvenile Myasthenia Gravis

Articles related to Juvenile Myasthenia Gravis:

(show top 50) (show all 125)
# Title Authors PMID Year
1
Corrigendum to "Workshop report: 242nd ENMC international workshop: Diagnosis and management of juvenile myasthenia gravis, Hoofddorp, the Netherlands, 1-3 March 2019" [Neuromuscular Disorders 30 (2020) 254-264]. 61
33602550 2021
2
Extended thymectomy via subxiphoid uniportal Video-Assisted Thoracoscopic Surgery: A case report. 61
33640643 2021
3
Developing outcome measures of disease activity in pediatric myasthenia. 61
33604899 2021
4
Outcomes of juvenile myasthenia gravis: a comparison of robotic thymectomy with medication treatment. 61
33482164 2021
5
Thymectomy in Juvenile Myasthenia Gravis Is Safe Regarding Long Term Immunological Effects. 61
33716918 2021
6
Rituximab as Adjunct Maintenance Therapy for Refractory Juvenile Myasthenia Gravis. 61
32951658 2020
7
Open versus thoracoscopic thymectomy for juvenile myasthenia gravis. 61
31826816 2020
8
What's in the Neuromuscular Junction Literature? 61
32453095 2020
9
242nd ENMC International Workshop: Diagnosis and management of juvenile myasthenia gravis Hoofddorp, the Netherlands, 1-3 March 2019. 61
32173249 2020
10
Response to treatment in pediatric ocular myasthenia gravis. 61
31650555 2020
11
Management of Juvenile Myasthenia Gravis. 61
32793107 2020
12
Cell-Based Versus Enzyme-Linked Immunosorbent Assay for the Detection of Acetylcholine Receptor Antibodies in Chinese Juvenile Myasthenia Gravis. 61
31307830 2019
13
Pediatric Ocular Myasthenia Gravis. 61
31559492 2019
14
"Mummy, my eyelids are heavy": A case series of juvenile myasthenia gravis. 61
31390886 2019
15
Correlation of anti-acetylcholine receptor antibody levels and long-term outcomes of juvenile myasthenia gravis in Taiwan: a case control study. 61
31319795 2019
16
Thoracoscopic thymectomy for juvenile myasthenia gravis. 61
30729982 2019
17
Incidence and Ocular Features of Pediatric Myasthenias. 61
30653958 2019
18
[Treatment of juvenile myasthenia gravis]. 61
31603848 2019
19
Serial Stimulated Jitter Analysis In Juvenile Myasthenia Gravis. 61
30106469 2018
20
Clinical features and evolution of juvenile myasthenia gravis in a French cohort. 61
28877546 2018
21
Clinical Characteristics of Juvenile Myasthenia Gravis in Southern China. 61
29535672 2018
22
[Peripheral nervous system immunological disorder]. 61
30199371 2018
23
Juvenile myasthenia gravis in Norway: Clinical characteristics, treatment, and long-term outcome in a nationwide population-based cohort. 61
28457757 2017
24
Juvenile myasthenia gravis. 61
28784230 2017
25
Outcome after Robotic-Assisted Thymectomy in Children and Adolescents with Acetylcholine Receptor Antibody-Positive Juvenile Myasthenia Gravis. 61
28628938 2017
26
The role of thymectomy in the treatment of juvenile myasthenia gravis: a systematic review. 61
28401300 2017
27
Pediatric Myasthenia Gravis. 61
28941526 2017
28
Results of surgical treatment for juvenile myasthenia gravis. 61
26585984 2017
29
Juvenile myasthenia gravis in Norway: A nationwide epidemiological study. 61
27666466 2017
30
[The pitfalls of using diagnosis and treatment guidelines for patients with juvenile myasthenia gravis]. 61
30113150 2017
31
Juvenile myasthenia gravis in Norway: HLA-DRB1*04:04 is positively associated with prepubertal onset. 61
29036181 2017
32
Early onset bilateral juvenile myasthenia gravis masquerading as simple congenital ptosis. 61
28293536 2017
33
[Juvenile myasthenia gravis in sub-Saharan Africa: a case study of two consanguine sisters born from consanguinity in Togo]. 61
29230265 2017
34
Anti-MuSK-Positive Myasthenic Crisis in a 7-Year-Old Female. 61
28540092 2017
35
Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age. 61
27581849 2016
36
Multidisciplinary treatment for prepubertal juvenile myasthenia gravis with crisis. 61
27324449 2016
37
Outcomes of thoracoscopic thymectomy in patients with juvenile myasthenia gravis. 61
26831531 2016
38
The African-387 C>T TGFB1 variant is functional and associates with the ophthalmoplegic complication in juvenile myasthenia gravis. 61
26632886 2016
39
Co-existence of juvenile-onset systemic lupus erythematosus and juvenile myasthenia gravis. 61
26085593 2015
40
[Clinical characteristics and managements of juvenile myasthenia gravis]. 61
26480755 2015
41
[Effects of thymectomy on bone age and height development in juvenile myasthenia gravis]. 61
26675797 2015
42
Ophthalmological manifestations in patients with Leigh syndrome. 61
25351680 2015
43
[Delayed development of multiple supernumerary teeth in a patient with juvenile myasthenia gravis treated with azathioprine]. 61
24315416 2014
44
Comparison of plasmapheresis and intravenous immunoglobulin as maintenance therapies for juvenile myasthenia gravis. 61
24590389 2014
45
Juvenile myasthenia gravis: recommendations for diagnostic approaches and treatment. 61
24470240 2014
46
Sevoflurane and thoracic epidural anesthesia for trans-sternal thymectomy in a child with juvenile myasthenia gravis. 61
24803774 2014
47
Outcome of children with acetylcholine receptor (AChR) antibody positive juvenile myasthenia gravis following thymectomy. 61
24239058 2014
48
The effect of steroid treatment and thymectomy on bone age and height development in juvenile myasthenia gravis. 61
23619530 2013
49
Update on juvenile myasthenia gravis. 61
24141560 2013
50
Clinical characteristics of pediatric myasthenia: a surveillance study. 61
24019417 2013

Variations for Juvenile Myasthenia Gravis

Expression for Juvenile Myasthenia Gravis

Search GEO for disease gene expression data for Juvenile Myasthenia Gravis.

Pathways for Juvenile Myasthenia Gravis

Pathways related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 TGFB1 IL10 HLA-DRB1
2
Show member pathways
12.32 TGFB1 IL10 HLA-DRB1
3
Show member pathways
11.97 TGFB1 IL10 HLA-DRB1
4 11.92 TGFB1 HLA-DRB1
5
Show member pathways
11.69 TGFB1 IL10
6
Show member pathways
11.61 TGFB1 IL10 HLA-DRB1
7 11.6 TGFB1 IL10
8 11.54 TGFB1 IL10
9 11.51 IL10 HLA-DRB1
10 11.48 TGFB1 HLA-DRB1
11 11.39 TGFB1 IL10 HLA-DRB1
12
Show member pathways
11.38 TGFB1 IL10
13 11.35 TGFB1 IL10
14 11.28 TGFB1 IL10
15 11.13 TGFB1 IL10
16
Show member pathways
10.92 TGFB1 IL10
17 10.77 TGFB1 HLA-DRB1
18 10.26 TGFB1 IL10 HLA-DRB1

GO Terms for Juvenile Myasthenia Gravis

Biological processes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.54 TGFB1 IL10 HLA-DRB1
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.48 TGFB1 HLA-DRB1
3 positive regulation of protein phosphorylation GO:0001934 9.46 TGFB1 HLA-DRB1
4 aging GO:0007568 9.43 TGFB1 IL10
5 response to organic substance GO:0010033 9.4 TGFB1 IL10
6 negative regulation of interferon-gamma production GO:0032689 9.32 IL10 HLA-DRB1
7 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.26 TGFB1 IL10
8 negative regulation of mitotic cell cycle GO:0045930 9.16 TGFB1 IL10
9 liver regeneration GO:0097421 8.96 TGFB1 IL10
10 negative regulation of T cell proliferation GO:0042130 8.8 TGFB1 IL10 HLA-DRB1

Molecular functions related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.62 TGFB1 IL10

Sources for Juvenile Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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