MCID: JVN038
MIFTS: 34

Juvenile Myasthenia Gravis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Juvenile Myasthenia Gravis

MalaCards integrated aliases for Juvenile Myasthenia Gravis:

Name: Juvenile Myasthenia Gravis 60
Juvenile Autoimmune Myasthenia Gravis 60
Juvenile Acquired Myasthenia 60
Childhood Myasthenia Gravis 60

Characteristics:

Orphanet epidemiological data:

60
juvenile myasthenia gravis
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:



External Ids:

ICD10 via Orphanet 35 G70.0
Orphanet 60 ORPHA391497

Summaries for Juvenile Myasthenia Gravis

MalaCards based summary : Juvenile Myasthenia Gravis, also known as juvenile autoimmune myasthenia gravis, is related to systemic lupus erythematosus and myasthenia gravis. An important gene associated with Juvenile Myasthenia Gravis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include bone, lung and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Myasthenia Gravis

Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Juvenile Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 29.1 HLA-DRB1 IL10 TGFB1
2 myasthenia gravis 10.9
3 myasthenia gravis congenital 10.9
4 ptosis 10.1
5 eosinophilia-myalgia syndrome 10.0 HLA-DRB1 TGFB1
6 osteonecrosis of the jaw 10.0 HLA-DRB1 TGFB1
7 oligoarticular juvenile idiopathic arthritis 10.0 HLA-DRB1 TGFB1
8 ocular cicatricial pemphigoid 10.0 HLA-DRB1 TGFB1
9 congenital ptosis 10.0
10 suppression amblyopia 10.0
11 amblyopia 10.0
12 lupus erythematosus 10.0
13 anemia, autoimmune hemolytic 9.9
14 hemolytic anemia 9.9
15 inflammatory bowel disease 9.9 IL10 TGFB1
16 inflammatory bowel disease 25, autosomal recessive 9.9 IL10 TGFB1
17 clonorchiasis 9.9 IL10 TGFB1
18 tuberculoid leprosy 9.9 IL10 TGFB1
19 autoimmune gastritis 9.9 IL10 TGFB1
20 chronic active epstein-barr virus infection 9.9 IL10 TGFB1
21 paranasal sinus disease 9.9 IL10 TGFB1
22 prostatitis 9.9 IL10 TGFB1
23 discoid lupus erythematosus 9.9 HLA-DRB1 IL10
24 cystic echinococcosis 9.9 HLA-DRB1 IL10
25 echinococcosis 9.9 HLA-DRB1 IL10
26 peanut allergy 9.9 HLA-DRB1 IL10
27 acute disseminated encephalomyelitis 9.9 HLA-DRB1 IL10
28 panuveitis 9.8 HLA-DRB1 IL10
29 ureteral obstruction 9.8 IL10 TGFB1
30 polyradiculoneuropathy 9.8 HLA-DRB1 IL10
31 autoimmune pancreatitis 9.8 HLA-DRB1 IL10
32 rheumatic fever 9.8 HLA-DRB1 IL10
33 chronic fatigue syndrome 9.8 IL10 TGFB1
34 mixed connective tissue disease 9.8 HLA-DRB1 IL10
35 connective tissue disease 9.8 HLA-DRB1 IL10
36 primary progressive multiple sclerosis 9.8 HLA-DRB1 IL10
37 dengue hemorrhagic fever 9.8 HLA-DRB1 IL10
38 chagas disease 9.8 IL10 TGFB1
39 vogt-koyanagi-harada disease 9.8 HLA-DRB1 IL10
40 autoimmune disease of central nervous system 9.8 HLA-DRB1 IL10
41 autoimmune disease 9.8 HLA-DRB1 IL10
42 rubella 9.8 HLA-DRB1 IL10
43 bone inflammation disease 9.8 HLA-DRB1 IL10
44 respiratory system disease 9.8 IL10 TGFB1
45 graft-versus-host disease 9.8 HLA-DRB1 IL10
46 pulmonary tuberculosis 9.7 HLA-DRB1 IL10
47 interstitial lung disease 9.7 IL10 TGFB1
48 lung disease 9.7 IL10 TGFB1
49 leishmaniasis 9.7 HLA-DRB1 IL10
50 rheumatic disease 9.6 HLA-DRB1 IL10

Graphical network of the top 20 diseases related to Juvenile Myasthenia Gravis:



Diseases related to Juvenile Myasthenia Gravis

Symptoms & Phenotypes for Juvenile Myasthenia Gravis

GenomeRNAi Phenotypes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

27 (show all 33)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.21 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.21 TGFB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.21 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.21 TGFB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.21 HLA-DRB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.21 TGFB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.21 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.21 IL10 HLA-DRB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.21 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.21 HLA-DRB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.21 TGFB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.21 TGFB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.21 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.21 TGFB1 HLA-DRB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.21 HLA-DRB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.21 TGFB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.21 HLA-DRB1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.21 HLA-DRB1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.21 IL10 TGFB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.21 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.21 IL10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.21 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.21 TGFB1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.21 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.21 TGFB1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.21 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.21 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.21 IL10 HLA-DRB1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.21 IL10
31 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.21 IL10
32 Decreased viability with paclitaxel GR00179-A-1 9.13 IL10 TGFB1
33 Decreased viability with paclitaxel GR00179-A-3 9.13 TGFB1

Drugs & Therapeutics for Juvenile Myasthenia Gravis

Search Clinical Trials , NIH Clinical Center for Juvenile Myasthenia Gravis

Genetic Tests for Juvenile Myasthenia Gravis

Anatomical Context for Juvenile Myasthenia Gravis

MalaCards organs/tissues related to Juvenile Myasthenia Gravis:

42
Bone, Lung, Eye, Testes, Thymus, Heart, Prostate

Publications for Juvenile Myasthenia Gravis

Articles related to Juvenile Myasthenia Gravis:

(show top 50) (show all 73)
# Title Authors Year
1
Thoracoscopic thymectomy for juvenile myasthenia gravis. ( 30729982 )
2019
2
Clinical features and evolution of juvenile myasthenia gravis in a French cohort. ( 28877546 )
2018
3
Clinical Characteristics of Juvenile Myasthenia Gravis in Southern China. ( 29535672 )
2018
4
Serial Stimulated Jitter Analysis In Juvenile Myasthenia Gravis. ( 30106469 )
2018
5
Early onset bilateral juvenile myasthenia gravis masquerading as simple congenital ptosis. ( 28293536 )
2017
6
Results of surgical treatment for juvenile myasthenia gravis. ( 26585984 )
2017
7
Juvenile myasthenia gravis in Norway: A nationwide epidemiological study. ( 27666466 )
2017
8
The role of thymectomy in the treatment of juvenile myasthenia gravis: a systematic review. ( 28401300 )
2017
9
Juvenile myasthenia gravis in Norway: Clinical characteristics, treatment, and long-term outcome in a nationwide population-based cohort. ( 28457757 )
2017
10
Outcome after Robotic-Assisted Thymectomy in Children and Adolescents with Acetylcholine Receptor Antibody-Positive Juvenile Myasthenia Gravis. ( 28628938 )
2017
11
Juvenile myasthenia gravis. ( 28784230 )
2017
12
Juvenile myasthenia gravis in Norway: HLA-DRB1*04:04 is positively associated with prepubertal onset. ( 29036181 )
2017
13
The African-387 C>T TGFB1 variant is functional and associates with the ophthalmoplegic complication in juvenile myasthenia gravis. ( 26632886 )
2016
14
Outcomes of thoracoscopic thymectomy in patients with juvenile myasthenia gravis. ( 26831531 )
2016
15
Multidisciplinary treatment for prepubertal juvenile myasthenia gravis with crisis. ( 27324449 )
2016
16
Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age. ( 27581849 )
2016
17
Co-existence of juvenile-onset systemic lupus erythematosus and juvenile myasthenia gravis. ( 26085593 )
2015
18
Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis. ( 25780436 )
2015
19
Outcome of children with acetylcholine receptor (AChR) antibody positive juvenile myasthenia gravis following thymectomy. ( 24239058 )
2014
20
Juvenile myasthenia gravis: recommendations for diagnostic approaches and treatment. ( 24470240 )
2014
21
Comparison of plasmapheresis and intravenous immunoglobulin as maintenance therapies for juvenile myasthenia gravis. ( 24590389 )
2014
22
Sevoflurane and thoracic epidural anesthesia for trans-sternal thymectomy in a child with juvenile myasthenia gravis. ( 24803774 )
2014
23
Management of juvenile myasthenia gravis. ( 23337001 )
2013
24
Clinical outcome of juvenile myasthenia gravis after extended transsternal thymectomy in a chinese cohort. ( 23374447 )
2013
25
Efficacy and safety of thoracoscopic thymectomy in the treatment of juvenile myasthenia gravis. ( 23423693 )
2013
26
Juvenile myasthenia gravis: a twenty-year experience. ( 23492460 )
2013
27
The effect of steroid treatment and thymectomy on bone age and height development in juvenile myasthenia gravis. ( 23619530 )
2013
28
Update on juvenile myasthenia gravis. ( 24141560 )
2013
29
The characteristics of juvenile myasthenia gravis among South Africans. ( 22668957 )
2012
30
Rituximab in severe seronegative juvenile myasthenia gravis: review of the literature. ( 22883288 )
2012
31
Thymectomy for inducing remission in juvenile myasthenia gravis. ( 21243366 )
2011
32
Hybrid combination of small subxiphoid incision and thoracoscopic thymectomy for juvenile myasthenia gravis. ( 21496556 )
2011
33
Anesthesia for patients undergoing transsternal thymectomy for juvenile myasthenia gravis. ( 21655012 )
2011
34
Juvenile myasthenia gravis: a paediatric perspective. ( 22110902 )
2011
35
Childhood myasthenia gravis: clinical features and outcomes. ( 22043769 )
2011
36
Juvenile myasthenia gravis. ( 19229875 )
2009
37
Juvenile myasthenia gravis: three case reports and a literature review. ( 19406758 )
2009
38
Ptosis and cranial nerve IV palsy reveal juvenile myasthenia gravis. ( 19545846 )
2009
39
Long-term clinical outcome after extended thymectomy combined postoperative high-dose steroid therapy for juvenile myasthenia gravis. ( 18414352 )
2008
40
A combination of total intravenous anesthesia and thoracic epidural for thymectomy in juvenile myasthenia gravis. ( 17359407 )
2007
41
High interleukin-10 production is associated with anti-acetylcholine receptor antibody production and treatment response in juvenile myasthenia gravis. ( 17917921 )
2007
42
Juvenile myasthenia gravis mimicking recurrent VI nerve palsy of childhood. ( 14709527 )
2004
43
Antibodies against muscle-specific kinase in juvenile myasthenia gravis. ( 12776235 )
2003
44
Thoracoscopic thymectomy for juvenile myasthenia gravis. ( 12522275 )
2002
45
[Thymectomy in juvenile myasthenia gravis]. ( 12221621 )
2002
46
Foreign body aspiration: a presenting sign of juvenile myasthenia gravis. ( 11506135 )
2001
47
Video-assisted thoracoscopic thymectomy in juvenile myasthenia gravis. ( 11510927 )
2001
48
High-dose intravenous immunoglobulin therapy in juvenile myasthenia gravis. ( 10669204 )
2000
49
Thoracoscopic thymectomy in juvenile myasthenia gravis. ( 10813346 )
2000
50
Juvenile myasthenia gravis: treatment with immune globulin and thymectomy. ( 9492094 )
1998

Variations for Juvenile Myasthenia Gravis

Expression for Juvenile Myasthenia Gravis

Search GEO for disease gene expression data for Juvenile Myasthenia Gravis.

Pathways for Juvenile Myasthenia Gravis

Pathways related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 HLA-DRB1 IL10 TGFB1
2
Show member pathways
12.35 HLA-DRB1 IL10 TGFB1
3
Show member pathways
12.12 IL10 TGFB1
4
Show member pathways
11.97 HLA-DRB1 IL10 TGFB1
5 11.92 HLA-DRB1 TGFB1
6
Show member pathways
11.7 IL10 TGFB1
7
Show member pathways
11.66 IL10 TGFB1
8
Show member pathways
11.6 HLA-DRB1 IL10 TGFB1
9 11.59 IL10 TGFB1
10 11.51 IL10 TGFB1
11 11.47 HLA-DRB1 TGFB1
12 11.38 HLA-DRB1 IL10 TGFB1
13 11.36 IL10 TGFB1
14 11.33 IL10 TGFB1
15 11.29 HLA-DRB1 IL10
16 11.09 IL10 TGFB1
17 11.02 IL10 TGFB1
18 10.77 HLA-DRB1 TGFB1
19 10.26 HLA-DRB1 IL10 TGFB1

GO Terms for Juvenile Myasthenia Gravis

Biological processes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.43 IL10 TGFB1
2 aging GO:0007568 9.4 IL10 TGFB1
3 response to organic substance GO:0010033 9.37 IL10 TGFB1
4 liver regeneration GO:0097421 9.32 IL10 TGFB1
5 negative regulation of mitotic cell cycle GO:0045930 9.26 IL10 TGFB1
6 negative regulation of interferon-gamma production GO:0032689 9.16 HLA-DRB1 IL10
7 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.96 IL10 TGFB1
8 negative regulation of T cell proliferation GO:0042130 8.8 HLA-DRB1 IL10 TGFB1

Molecular functions related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 IL10 TGFB1
2 growth factor activity GO:0008083 8.62 IL10 TGFB1

Sources for Juvenile Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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