MCID: JVN038
MIFTS: 32

Juvenile Myasthenia Gravis

Categories: Neuronal diseases, Rare diseases, Immune diseases

Aliases & Classifications for Juvenile Myasthenia Gravis

MalaCards integrated aliases for Juvenile Myasthenia Gravis:

Name: Juvenile Myasthenia Gravis 59
Juvenile Autoimmune Myasthenia Gravis 59
Juvenile Acquired Myasthenia 59
Childhood Myasthenia Gravis 59

Characteristics:

Orphanet epidemiological data:

59
juvenile myasthenia gravis
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA391497
ICD10 via Orphanet 34 G70.0

Summaries for Juvenile Myasthenia Gravis

MalaCards based summary : Juvenile Myasthenia Gravis, also known as juvenile autoimmune myasthenia gravis, is related to aging and myasthenia gravis. An important gene associated with Juvenile Myasthenia Gravis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Myasthenia Gravis

Diseases in the Myasthenia Gravis family:

Myasthenia Gravis Congenital Juvenile Myasthenia Gravis
Adult-Onset Myasthenia Gravis

Diseases related to Juvenile Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 aging 29.3 IL10 TGFB1
2 myasthenia gravis 10.6
3 myasthenia gravis congenital 10.6
4 beryllium disease 10.1 HLA-DRB1 TGFB1
5 eosinophilia-myalgia syndrome 10.1 HLA-DRB1 TGFB1
6 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DRB1 TGFB1
7 ocular cicatricial pemphigoid 10.0 HLA-DRB1 TGFB1
8 ptosis 10.0
9 inflammatory bowel disease 25, autosomal recessive 9.9 IL10 TGFB1
10 tuberculoid leprosy 9.9 IL10 TGFB1
11 clonorchiasis 9.9 IL10 TGFB1
12 chronic active epstein-barr virus infection 9.8 IL10 TGFB1
13 systemic lupus erythematosus 9.8
14 congenital ptosis 9.8
15 lupus erythematosus 9.8
16 paranasal sinus disease 9.8 IL10 TGFB1
17 prostatitis 9.8 IL10 TGFB1
18 microscopic polyangiitis 9.8 HLA-DRB1 IL10
19 acute disseminated encephalomyelitis 9.7 HLA-DRB1 IL10
20 ureteral obstruction 9.7 IL10 TGFB1
21 discoid lupus erythematosus 9.7 HLA-DRB1 IL10
22 cystic echinococcosis 9.7 HLA-DRB1 IL10
23 peanut allergy 9.7 HLA-DRB1 IL10
24 hemorrhagic fever 9.7 HLA-DRB1 IL10
25 panuveitis 9.7 HLA-DRB1 IL10
26 severe hemophilia a 9.7 HLA-DRB1 IL10
27 chronic fatigue syndrome 9.7 IL10 TGFB1
28 hemorrhagic fever with renal syndrome 9.7 HLA-DRB1 IL10
29 respiratory system disease 9.7 IL10 TGFB1
30 mixed connective tissue disease 9.7 HLA-DRB1 IL10
31 echinococcosis 9.7 HLA-DRB1 IL10
32 dengue hemorrhagic fever 9.7 HLA-DRB1 IL10
33 vogt-koyanagi-harada disease 9.7 HLA-DRB1 IL10
34 rubella 9.6 HLA-DRB1 IL10
35 chagas disease 9.6 IL10 TGFB1
36 bone inflammation disease 9.6 HLA-DRB1 IL10
37 helicobacter pylori infection 9.6 HLA-DRB1 IL10
38 hypersensitivity reaction disease 9.6 HLA-DRB1 IL10
39 graft-versus-host disease 9.6 HLA-DRB1 IL10
40 interstitial lung disease 9.6 IL10 TGFB1
41 rheumatic disease 9.5 HLA-DRB1 IL10
42 pulmonary tuberculosis 9.5 HLA-DRB1 IL10
43 leishmaniasis 9.5 HLA-DRB1 IL10
44 lung disease 9.4 IL10 TGFB1
45 connective tissue disease 9.4 HLA-DRB1 IL10
46 diabetes mellitus, insulin-dependent 9.2 HLA-DRB1 IL10
47 idiopathic neutropenia 9.1 HLA-DRB1 IL10 TGFB1
48 rheumatic heart disease 9.1 HLA-DRB1 IL10 TGFB1
49 arthritis 9.1 HLA-DRB1 IL10
50 rheumatoid arthritis 9.1 HLA-DRB1 IL10 TGFB1

Graphical network of the top 20 diseases related to Juvenile Myasthenia Gravis:



Diseases related to Juvenile Myasthenia Gravis

Symptoms & Phenotypes for Juvenile Myasthenia Gravis

GenomeRNAi Phenotypes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10 IL10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10 HLA-DRB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10 IL10 HLA-DRB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10 IL10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10 HLA-DRB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10 HLA-DRB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10 HLA-DRB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10 HLA-DRB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10 HLA-DRB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10 IL10
20 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10 HLA-DRB1 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10 IL10
23 Decreased viability with paclitaxel GR00179-A-1 9.13 IL10 TGFB1
24 Decreased viability with paclitaxel GR00179-A-3 9.13 TGFB1

Drugs & Therapeutics for Juvenile Myasthenia Gravis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Juvenile Myasthenia Gravis

Genetic Tests for Juvenile Myasthenia Gravis

Anatomical Context for Juvenile Myasthenia Gravis

MalaCards organs/tissues related to Juvenile Myasthenia Gravis:

41
Bone

Publications for Juvenile Myasthenia Gravis

Articles related to Juvenile Myasthenia Gravis:

(show all 40)
# Title Authors Year
1
Clinical Characteristics of Juvenile Myasthenia Gravis in Southern China. ( 29535672 )
2018
2
Juvenile myasthenia gravis in Norway: Clinical characteristics, treatment, and long-term outcome in a nationwide population-based cohort. ( 28457757 )
2017
3
Early onset bilateral juvenile myasthenia gravis masquerading as simple congenital ptosis. ( 28293536 )
2017
4
The role of thymectomy in the treatment of juvenile myasthenia gravis: a systematic review. ( 28401300 )
2017
5
Outcome after Robotic-Assisted Thymectomy in Children and Adolescents with Acetylcholine Receptor Antibody-Positive Juvenile Myasthenia Gravis. ( 28628938 )
2017
6
Juvenile myasthenia gravis. ( 28784230 )
2017
7
Clinical features and evolution of juvenile myasthenia gravis in a French cohort. ( 28877546 )
2017
8
Juvenile myasthenia gravis in Norway: HLA-DRB1*04:04 is positively associated with prepubertal onset. ( 29036181 )
2017
9
Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age. ( 27581849 )
2016
10
Outcomes of thoracoscopic thymectomy in patients with juvenile myasthenia gravis. ( 26831531 )
2016
11
The African-387 C>T TGFB1 variant is functional and associates with the ophthalmoplegic complication in juvenile myasthenia gravis. ( 26632886 )
2016
12
Juvenile myasthenia gravis in Norway: A nationwide epidemiological study. ( 27666466 )
2016
13
Multidisciplinary treatment for prepubertal juvenile myasthenia gravis with crisis. ( 27324449 )
2016
14
Co-existence of juvenile-onset systemic lupus erythematosus and juvenile myasthenia gravis. ( 26085593 )
2015
15
Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis. ( 25780436 )
2015
16
Results of surgical treatment for juvenile myasthenia gravis. ( 26585984 )
2015
17
Sevoflurane and thoracic epidural anesthesia for trans-sternal thymectomy in a child with juvenile myasthenia gravis. ( 24803774 )
2014
18
Outcome of children with acetylcholine receptor (AChR) antibody positive juvenile myasthenia gravis following thymectomy. ( 24239058 )
2014
19
Comparison of plasmapheresis and intravenous immunoglobulin as maintenance therapies for juvenile myasthenia gravis. ( 24590389 )
2014
20
Juvenile myasthenia gravis: recommendations for diagnostic approaches and treatment. ( 24470240 )
2014
21
Juvenile myasthenia gravis: a twenty-year experience. ( 23492460 )
2013
22
Clinical outcome of juvenile myasthenia gravis after extended transsternal thymectomy in a chinese cohort. ( 23374447 )
2013
23
Efficacy and safety of thoracoscopic thymectomy in the treatment of juvenile myasthenia gravis. ( 23423693 )
2013
24
The effect of steroid treatment and thymectomy on bone age and height development in juvenile myasthenia gravis. ( 23619530 )
2013
25
Update on juvenile myasthenia gravis. ( 24141560 )
2013
26
Management of juvenile myasthenia gravis. ( 23337001 )
2013
27
Rituximab in severe seronegative juvenile myasthenia gravis: review of the literature. ( 22883288 )
2012
28
The characteristics of juvenile myasthenia gravis among South Africans. ( 22668957 )
2012
29
Juvenile myasthenia gravis: a paediatric perspective. ( 22110902 )
2011
30
Hybrid combination of small subxiphoid incision and thoracoscopic thymectomy for juvenile myasthenia gravis. ( 21496556 )
2011
31
Thymectomy for inducing remission in juvenile myasthenia gravis. ( 21243366 )
2011
32
Childhood myasthenia gravis: clinical features and outcomes. ( 22043769 )
2011
33
Anesthesia for patients undergoing transsternal thymectomy for juvenile myasthenia gravis. ( 21655012 )
2011
34
Juvenile myasthenia gravis: three case reports and a literature review. ( 19406758 )
2009
35
Juvenile myasthenia gravis. ( 19229875 )
2009
36
Ptosis and cranial nerve IV palsy reveal juvenile myasthenia gravis. ( 19545846 )
2009
37
Long-term clinical outcome after extended thymectomy combined postoperative high-dose steroid therapy for juvenile myasthenia gravis. ( 18414352 )
2008
38
High interleukin-10 production is associated with anti-acetylcholine receptor antibody production and treatment response in juvenile myasthenia gravis. ( 17917921 )
2007
39
[Thymectomy in juvenile myasthenia gravis]. ( 12221621 )
2002
40
High-dose intravenous immunoglobulin therapy in juvenile myasthenia gravis. ( 10669204 )
2000

Variations for Juvenile Myasthenia Gravis

Expression for Juvenile Myasthenia Gravis

Search GEO for disease gene expression data for Juvenile Myasthenia Gravis.

Pathways for Juvenile Myasthenia Gravis

Pathways related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 HLA-DRB1 IL10 TGFB1
2
Show member pathways
12.35 HLA-DRB1 IL10 TGFB1
3
Show member pathways
11.98 IL10 TGFB1
4 11.97 HLA-DRB1 TGFB1
5 11.86 HLA-DRB1 IL10
6
Show member pathways
11.85 HLA-DRB1 IL10 TGFB1
7
Show member pathways
11.82 IL10 TGFB1
8
Show member pathways
11.66 IL10 TGFB1
9
Show member pathways
11.6 HLA-DRB1 IL10 TGFB1
10 11.57 IL10 TGFB1
11 11.48 IL10 TGFB1
12 11.43 HLA-DRB1 TGFB1
13 11.38 HLA-DRB1 IL10 TGFB1
14 11.33 IL10 TGFB1
15 11.15 HLA-DRB1 IL10
16 11.06 IL10 TGFB1
17 10.77 HLA-DRB1 TGFB1
18 10.28 HLA-DRB1 IL10 TGFB1

GO Terms for Juvenile Myasthenia Gravis

Biological processes related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.4 IL10 TGFB1
2 aging GO:0007568 9.37 IL10 TGFB1
3 response to organic substance GO:0010033 9.32 IL10 TGFB1
4 liver regeneration GO:0097421 9.26 IL10 TGFB1
5 negative regulation of mitotic cell cycle GO:0045930 9.16 IL10 TGFB1
6 negative regulation of interferon-gamma production GO:0032689 8.96 HLA-DRB1 IL10
7 negative regulation of T cell proliferation GO:0042130 8.8 HLA-DRB1 IL10 TGFB1

Molecular functions related to Juvenile Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 IL10 TGFB1
2 growth factor activity GO:0008083 8.62 IL10 TGFB1

Sources for Juvenile Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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