JNA
MCID: JVN033
MIFTS: 45

Juvenile Nasopharyngeal Angiofibroma (JNA)

Categories: Rare diseases

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

MalaCards integrated aliases for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 58 29
Nasopharyngeal Angiofibroma 70
Jna 58

Characteristics:

Orphanet epidemiological data:

58
juvenile nasopharyngeal angiofibroma
Inheritance: Not applicable; Age of onset: Adolescent,Childhood;

Classifications:



External Ids:

ICD10 via Orphanet 33 D10.6
Orphanet 58 ORPHA289596
UMLS 70 C1367536

Summaries for Juvenile Nasopharyngeal Angiofibroma

MalaCards based summary : Juvenile Nasopharyngeal Angiofibroma, also known as nasopharyngeal angiofibroma, is related to rare tumor and spindle cell sarcoma, and has symptoms including dyspnea, headache and tinnitus. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. Affiliated tissues include endothelial, eye and retina, and related phenotypes are juvenile nasopharyngeal angiofibroma and diplopia

Wikipedia : 73 Nasopharyngeal angiofibroma, also known as juvenile nasal angiofibroma, is a histologically benign but... more...

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
# Related Disease Score Top Affiliating Genes
1 rare tumor 31.0 KIT ACTC1
2 spindle cell sarcoma 30.4 VEGFA KIT ACTC1
3 angiomyolipoma 30.3 PGR KIT ESR1 ACTC1
4 fibrous histiocytoma 30.2 PECAM1 KIT ACTC1
5 fibrosarcoma 30.0 MYC KIT FGF2 ACTC1
6 sarcoma 29.9 VEGFA MYC KIT FGF2 ACTC1
7 vascular cancer 29.8 VEGFA PECAM1 KIT FGF2 ENG
8 hemangioma 29.5 VEGFA PGR PECAM1 MYC KIT FGF2
9 leiomyosarcoma 29.4 VEGFA PGR PECAM1 MYC KIT ESR1
10 glassy cell carcinoma of the cervix 10.4 PGR ESR1
11 breast intraductal papillomatosis 10.4 PGR ESR1
12 nipple carcinoma 10.4 PGR ESR1
13 bartholin's gland adenoma 10.4 PGR ESR1
14 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
15 uterine corpus adenosarcoma 10.4 PGR ESR1
16 bartholin's gland benign neoplasm 10.4 PGR ESR1
17 chronic tympanitis 10.4 PGR ESR1
18 vestibular gland benign neoplasm 10.4 PGR ESR1
19 granulomatous endometritis 10.4 PGR ESR1
20 vulvar syringoma 10.4 PGR ESR1
21 branch retinal artery occlusion 10.4
22 central retinal artery occlusion 10.4
23 retinal artery occlusion 10.4
24 exophthalmos 10.4
25 lymphangiomatosis 10.4 PGR PCNA
26 lung leiomyoma 10.4 PGR ESR1
27 scleromyxedema 10.4 FGF2 ACTC1
28 calcifying aponeurotic fibroma 10.4 PGR ACTC1
29 adult type testicular granulosa cell tumor 10.4 PGR ESR1
30 breast scirrhous carcinoma 10.4 PGR ESR1
31 oncocytic breast carcinoma 10.4 PGR ESR1
32 cervical clear cell adenocarcinoma 10.4 PGR ESR1
33 intravascular papillary endothelial hyperplasia 10.4 VEGFA ACTC1
34 dupuytren contracture 10.4 FGF2 BMP6
35 ovarian seromucinous carcinoma 10.4 PGR ESR1
36 breast papillary carcinoma 10.4 PGR ESR1
37 glycogen-rich clear cell breast carcinoma 10.4 PGR ACTC1
38 familial adenomatous polyposis 10.4
39 facial paralysis 10.4
40 intravenous leiomyomatosis 10.4 PGR ESR1
41 comedo carcinoma 10.4 PGR ESR1
42 breast adenoid cystic carcinoma 10.4 PGR ESR1
43 breast metaplastic carcinoma 10.4 PGR ESR1
44 ulcer of lower limbs 10.4 VEGFA FGF2
45 breast myoepithelial carcinoma 10.4 PGR ACTC1
46 subserous uterine fibroid 10.4 PGR CYP19A1
47 diffuse peritoneal leiomyomatosis 10.3 PGR CYP19A1
48 intracranial meningioma 10.3 PGR PCNA ESR1
49 lipodermatosclerosis 10.3 VEGFA PCNA
50 breast adenoma 10.3 PGR ESR1

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to Juvenile Nasopharyngeal Angiofibroma

Symptoms & Phenotypes for Juvenile Nasopharyngeal Angiofibroma

Human phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

58 31 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 juvenile nasopharyngeal angiofibroma 58 31 obligate (100%) Obligate (100%) HP:0030429
2 diplopia 58 31 frequent (33%) Frequent (79-30%) HP:0000651
3 proptosis 58 31 frequent (33%) Frequent (79-30%) HP:0000520
4 epistaxis 58 31 frequent (33%) Frequent (79-30%) HP:0000421
5 facial edema 58 31 frequent (33%) Frequent (79-30%) HP:0000282
6 nasal obstruction 58 31 frequent (33%) Frequent (79-30%) HP:0001742
7 increased intracranial pressure 58 31 occasional (7.5%) Occasional (29-5%) HP:0002516
8 juvenile colonic polyposis 58 31 very rare (1%) Very rare (<4-1%) HP:0012198

UMLS symptoms related to Juvenile Nasopharyngeal Angiofibroma:


dyspnea; headache; tinnitus

GenomeRNAi Phenotypes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in HCT116 cells GR00103-A-0 8.62 BMI1 PCNA

MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 ACTC1 CYP11A1 CYP19A1 ENG ESR1 FGF2
2 cardiovascular system MP:0005385 10.42 ACTC1 CFL1 CYP11A1 CYP19A1 ENG ESR1
3 cellular MP:0005384 10.41 ACTC1 CFL1 CYP11A1 CYP19A1 ESR1 FGF2
4 homeostasis/metabolism MP:0005376 10.41 ACTC1 CFL1 CYP11A1 CYP19A1 ENG ESR1
5 behavior/neurological MP:0005386 10.36 CFL1 CYP11A1 CYP19A1 ENG ESR1 FGF2
6 mortality/aging MP:0010768 10.33 ACTC1 CFL1 CYP11A1 ENG ESR1 FGF2
7 immune system MP:0005387 10.31 CYP11A1 CYP19A1 ESR1 KIT MYC PCNA
8 digestive/alimentary MP:0005381 10.21 CYP19A1 ENG ESR1 KIT MYC PECAM1
9 muscle MP:0005369 10.21 ACTC1 CYP11A1 CYP19A1 ENG ESR1 FGF2
10 embryo MP:0005380 10.2 ACTC1 CFL1 ENG ESR1 KIT MYC
11 endocrine/exocrine gland MP:0005379 10.19 CYP11A1 CYP19A1 ESR1 KIT MYC PCNA
12 nervous system MP:0003631 10.15 ACTC1 CFL1 CYP11A1 CYP19A1 ENG ESR1
13 limbs/digits/tail MP:0005371 10.02 ENG ESR1 KIT MYC PGR TGFB3
14 normal MP:0002873 10 ACTC1 CFL1 CYP11A1 CYP19A1 ENG ESR1
15 neoplasm MP:0002006 9.95 ESR1 FGF2 KIT MYC PGR TLR3
16 no phenotypic analysis MP:0003012 9.87 CFL1 ESR1 KIT MYC PCNA PGR
17 renal/urinary system MP:0005367 9.76 CFL1 CYP19A1 ESR1 KIT PECAM1 TLR7
18 reproductive system MP:0005389 9.7 BMP6 CYP11A1 CYP19A1 ESR1 FGF2 KIT
19 skeleton MP:0005390 9.36 BMP6 CYP11A1 CYP19A1 ESR1 FGF2 KIT

Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

Search Clinical Trials , NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

Genetic tests related to Juvenile Nasopharyngeal Angiofibroma:

# Genetic test Affiliating Genes
1 Juvenile Nasopharyngeal Angiofibroma 29

Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

40
Endothelial, Eye, Retina, Prostate, Pituitary

Publications for Juvenile Nasopharyngeal Angiofibroma

Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50) (show all 770)
# Title Authors PMID Year
1
Validation of Postoperative Angiofibroma Radionuclide Imaging Study (PARIS) Protocol Using PSMA PET/CT-A Proof of Concept Study. 61
33630789 2021
2
Direct Tumoral Puncture Onyx Embolization for a Juvenile Nasopharyngeal Angiofibroma in a Hybrid Neurointerventional Suite. 61
33309895 2021
3
Embolization of Internal Carotid Artery Branches in Juvenile Nasopharyngeal Angiofibroma. 61
33001464 2021
4
Review of Pediatric Head and Neck Neoplasms that Raise the Possibility of a Cancer Predisposition Syndrome. 61
33723760 2021
5
EBV-Positive Plasmacytomas Involving a Nasopharyngeal Angiofibroma in an Adolescent. 61
33683983 2021
6
Combined endoscopic and transoral resection of a high-staged juvenile nasopharyngeal angiofibroma: A pictorial essay. 61
33111428 2021
7
Combined Anterior Transmaxillary (Caldwell-Luc) With an Endoscopic Endonasal Transpterygoid Approach for Resection of a Large Juvenile Nasopharyngeal Angiofibroma: 2-Dimensional Operative Video. 61
33372963 2021
8
Fusion 68Ga-DOTANOC PET/MRI in Primary Juvenile Nasal Angiofibroma. 61
33630795 2021
9
Advantage of 68Ga-PSMA PET/CT on Postradiotherapy Response Assessment of Juvenile Nasal Angiofibroma. 61
33156054 2021
10
Angiofibroma of the Nasal Cavity in a Dog: Case Report. 61
33636377 2021
11
Clinical utility of Ga68 DOTANOC PET/CT imaging in juvenile nasal angiofibroma and the PARIS protocol: a preliminary report. 61
33481507 2021
12
Juvenile nasopharyngeal angiofibroma in a male of 16 years old. A case report. 61
33489182 2021
13
Endoscopic Endonasal and Transmaxillary Approach for Resection of Juvenile Nasopharyngeal Angiofibroma With Preoperative Embolization in a Child. 61
33534320 2021
14
Diode Laser Management of Primary Extranasopharyngeal Angiofibroma Presenting as Maxillary Epulis: Report of a Case and Literature Review. 61
33401498 2021
15
Cerebral amyloid angiopathy in a 51-year-old patient with embolization by dura mater extract and surgery for nasopharyngeal angiofibroma at age 17. 61
33274650 2020
16
68 Ga DOTANOC PET/CT Scan in Primary Juvenile Nasopharyngeal Angiofibroma - A Pilot Study. 61
33355921 2020
17
Plasma ablation-assisted endoscopic excision versus traditional technique of endoscopic excision of juvenile nasopharyngeal angiofibroma. 61
33022553 2020
18
Can palatovaginal canal be the site of origin of juvenile nasopharyngeal angiofibroma? 61
33254490 2020
19
Spontaneous Involution of Juvenile Nasopharyngeal Angiofibromas: Report of a Case. 61
33174222 2020
20
Robotic-assisted transmaxillary approach for removal of juvenile nasopharyngeal angiofibroma of the pterygopalatine and infratemporal fossa. 61
32364647 2020
21
The role of diagnostic and interventional radiology in juvenile nasopharyngeal angiofibroma: A case report and literature review. 61
32346460 2020
22
Olfaction in Juvenile Nasopharyngeal Angiofibroma: The first study. 61
32451287 2020
23
Fusion 68Ga-Prostate-Specific Membrane Antigen PET/MRI on Postoperative Surveillance of Juvenile Nasal Angiofibroma. 61
32404701 2020
24
A safer endovascular technique for pre-operative embolization of juvenile nasopharyngeal angiofibroma: avoiding the pitfalls of external carotid artery - internal carotid artery anastomoses. 61
32665917 2020
25
Juvenile Nasopharyngeal Angiofibroma and Familial Adenomatous Polyposis. 61
32543227 2020
26
Juvenile Nasopharyngeal Angiofibroma Outcomes and Cost: Analysis of the Kids' Inpatient Database. 61
31876164 2020
27
Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma. 61
31925925 2020
28
Comparison of 68Ga-PSMA PET/CT and Contrast-Enhanced MRI on Residual Disease Assessment of Juvenile Nasal Angiofibroma. 61
32049728 2020
29
Trimodal embolization of juvenile nasopharyngeal angiofibroma with intracranial extension. 61
31864085 2020
30
Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck. 61
31950474 2020
31
Clinical Applications of 68Ga-PSMA PET/CT on Residual Disease Assessment of Juvenile Nasopharyngeal Angiofibroma (JNA). 61
32206135 2020
32
[Experience of transnazal endoscopic surgery of juvenile angiofibroma of the skull base and nasopharynx without performing preoperative embolization]. 61
32885644 2020
33
Mixed olfactory neuroblastoma and neuroendocrine carcinoma: An unusual case report and literature review. 61
32494376 2020
34
Recurrence Rate after Endoscopic vs. Open Approaches for Juvenile Nasopharyngeal Angiofibroma: A Meta-analysis. 61
31750043 2019
35
Tissue microarray analysis reveals that cofilin expression is a poor prognostic factor in juvenile nasopharyngeal angiofibroma. 61
31623023 2019
36
The Genetic and Molecular Determinants of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review. 61
31148463 2019
37
Is 'Group and Save' Blood Request Routinely Required for Nasopharyngeal Biopsy? 61
31763234 2019
38
Massive Angiomatous Nasal Polyp Mimicking Nasopharyngeal Angiofibroma. 61
31763304 2019
39
Extra Nasopharyngeal Angiofibroma from Lateral Nasal Wall: A Rare Case Report. 61
31763305 2019
40
Endoscopic Resection of Pediatric Skull Base Tumors: An Evidence-Based Review. 61
31534896 2019
41
Juvenile nasopharyngeal angiofibroma with intracranial extension - diagnosis and treatment. 61
32022702 2019
42
Nasolacrimal Duct Management During Endoscopic Sinus and Skull Base Surgery. 61
31088142 2019
43
From Juvenile Nasopharyngeal Angiofibroma to Nasopharyngeal Carcinoma; A Rare Case Report of Nasopharyngeal Mass. 61
31858008 2019
44
Juvenile nasopharyngeal angiofibroma surgical treatment in paediatric patients. 61
30093086 2019
45
Juvenile nasopharyngeal angiofibroma in prepubertal males: A diagnostic dilemma. 61
30569464 2019
46
Case Series of Pre-Operative Endovascular Embolization of Nasopharyngeal Angiofibroma Using Polyvinyl Alcohol Foam Particle: A Single Centre Experience. 61
31666855 2019
47
Nasopharyngeal Angiofibroma Staging with a Novel Nominal Basis: An 18-Year Study in a Tertiary Center. 61
31012381 2019
48
Posterior Nasal Pack After Transpalatal Excision of Juvenile Nasopharyngeal Angiofibroma: Can It be Avoided? 61
31275844 2019
49
Current perspectives on the origin theory of juvenile nasopharyngeal angiofibroma. 61
31421693 2019
50
Occurrence of Hemi-Central Retinal Artery Occlusion Following Embolization in a Case of Recurrent Juvenile Nasopharyngeal Angiofibroma. 61
31233156 2019

Variations for Juvenile Nasopharyngeal Angiofibroma

Expression for Juvenile Nasopharyngeal Angiofibroma

Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for Juvenile Nasopharyngeal Angiofibroma

Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 TLR9 TLR7 TLR3 TGFB3 KIT FGF2
2
Show member pathways
13.13 TLR9 TLR7 TLR3 TGFB3 PCNA MYC
3
Show member pathways
12.8 VEGFA TGFB3 PCNA MYC KIT
4 12.7 VEGFA TGFB3 MYC KIT FGF2 ESR1
5 12.68 VEGFA TGFB3 MYC KIT FGF2
6
Show member pathways
12.6 TGFB3 PGR MYC KIT FGF2 ESR1
7 12.44 TLR9 TLR7 TLR3 PECAM1 KIT
8
Show member pathways
12.35 TLR9 TLR7 TLR3 TGFB3 FGF2 BMP6
9
Show member pathways
12.32 TGFB3 KIT FGF2 CFL1 BMP6
10 12.22 VEGFA MYC FGF2 ESR1
11
Show member pathways
12.14 TGFB3 MYC KIT FGF2 BMP6
12 12.06 VEGFA MYC ESR1 CYP19A1
13 11.94 VEGFA MYC FGF2 BMI1
14 11.81 TGFB3 MYC BMP6
15 11.75 TLR9 TLR7 TLR3
16 11.72 TGFB3 MYC ESR1 ENG
17 11.71 VEGFA FGF2 BMI1
18
Show member pathways
11.69 TLR9 TLR7 TLR3
19 11.67 TLR9 TLR7 KIT
20
Show member pathways
11.67 VEGFA MYC KIT ESR1
21
Show member pathways
11.63 TLR9 TLR7 TLR3 TGFB3
22 11.6 VEGFA FGF2 BMP6
23 11.57 TGFB3 PECAM1 FGF2 ENG
24 11.5 KIT FGF2 ACTC1
25 11.48 CYP19A1 CYP11A1 BMP6
26 11.46 TLR9 TGFB3 PECAM1
27 11.43 VEGFA MYC ESR1
28 11.37 VEGFA MYC FGF2
29 11.33 TGFB3 KIT FGF2 ENG BMP6
30 11.32 VEGFA TLR9 TLR7 TLR3 TGFB3 MYC
31 11.14 VEGFA TGFB3 KIT FGF2
32 11.07 VEGFA TGFB3 FGF2
33 10.95 TGFB3 KIT FGF2 CFL1 BMP6
34 10.15 ESR1 CYP19A1

GO Terms for Juvenile Nasopharyngeal Angiofibroma

Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 VEGFA TLR3 TGFB3 PECAM1 KIT FGF2
2 early phagosome GO:0032009 9.16 TLR9 TLR7
3 endolysosome membrane GO:0036020 8.8 TLR9 TLR7 TLR3

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.16 VEGFA TLR9 TLR7 TLR3 TGFB3 PGR
2 negative regulation of transcription by RNA polymerase II GO:0000122 10.07 VEGFA PCNA MYC ESR1 ENG BMP6
3 inflammatory response GO:0006954 10.03 TLR9 TLR7 TLR3 KIT BMP6
4 positive regulation of cell proliferation GO:0008284 10.01 VEGFA TGFB3 MYC KIT FGF2 BMP6
5 negative regulation of gene expression GO:0010629 9.97 VEGFA PGR FGF2 ESR1 ENG
6 positive regulation of protein phosphorylation GO:0001934 9.95 VEGFA PECAM1 FGF2 ENG
7 positive regulation of angiogenesis GO:0045766 9.9 VEGFA TLR3 FGF2 ENG
8 positive regulation of inflammatory response GO:0050729 9.87 TLR9 TLR7 TLR3
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.86 VEGFA PECAM1 BMP6
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.86 VEGFA KIT FGF2
11 positive regulation of interleukin-6 production GO:0032755 9.86 TLR9 TLR7 TLR3
12 BMP signaling pathway GO:0030509 9.85 TGFB3 ENG BMP6
13 positive regulation of endothelial cell proliferation GO:0001938 9.84 VEGFA FGF2 BMP6
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 TLR9 TLR7 TLR3
15 positive regulation of interferon-gamma production GO:0032729 9.83 TLR9 TLR7 TLR3
16 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.83 TLR9 TLR7 TLR3
17 positive regulation of MAP kinase activity GO:0043406 9.81 VEGFA KIT FGF2
18 positive regulation of interleukin-8 production GO:0032757 9.81 TLR9 TLR7 TLR3
19 positive regulation of MAPK cascade GO:0043410 9.81 VEGFA TLR9 KIT FGF2
20 positive regulation of fibroblast proliferation GO:0048146 9.8 MYC ESR1 BMI1
21 positive regulation of protein kinase B signaling GO:0051897 9.8 VEGFA KIT FGF2 ESR1 ENG
22 positive regulation of cell division GO:0051781 9.79 VEGFA TGFB3 FGF2
23 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.79 TGFB3 ENG BMP6
24 toll-like receptor signaling pathway GO:0002224 9.78 TLR9 TLR7 TLR3
25 positive regulation of chemokine production GO:0032722 9.75 TLR9 TLR7 TLR3
26 positive regulation of interferon-beta production GO:0032728 9.73 TLR9 TLR7 TLR3
27 cellular response to mechanical stimulus GO:0071260 9.73 TLR7 TLR3 ENG BMP6
28 positive regulation of vascular permeability GO:0043117 9.68 VEGFA BMP6
29 intracellular steroid hormone receptor signaling pathway GO:0030518 9.67 PGR ESR1
30 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.67 VEGFA BMP6
31 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.66 KIT ENG
32 positive regulation of interferon-alpha production GO:0032727 9.65 TLR9 TLR7 TLR3
33 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 VEGFA TLR9 TLR3 TGFB3 PGR MYC
34 paracrine signaling GO:0038001 9.64 PGR FGF2
35 positive regulation of epithelial cell proliferation GO:0050679 9.62 VEGFA MYC FGF2 BMP6
36 positive regulation of epithelial tube formation GO:1905278 9.59 VEGFA FGF2
37 positive regulation of toll-like receptor signaling pathway GO:0034123 9.58 TLR9 TLR3
38 negative regulation of adherens junction organization GO:1903392 9.55 VEGFA BMP6
39 positive regulation of DNA biosynthetic process GO:2000573 9.54 VEGFA MYC FGF2
40 detection of hypoxia GO:0070483 9.49 TGFB3 ENG
41 positive regulation of phospholipase C activity GO:0010863 9.43 KIT FGF2 ESR1
42 I-kappaB phosphorylation GO:0007252 9.33 TLR9 TLR7 TLR3
43 positive regulation of gene expression GO:0010628 9.28 VEGFA TLR9 TLR3 MYC KIT FGF2

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.76 VEGFA TLR3 TGFB3 PGR PCNA FGF2
2 cytokine activity GO:0005125 9.62 VEGFA TGFB3 FGF2 BMP6
3 pattern recognition receptor activity GO:0038187 9.43 TLR9 TLR7
4 siRNA binding GO:0035197 9.4 TLR9 TLR7
5 type I transforming growth factor beta receptor binding GO:0034713 9.37 TGFB3 ENG
6 type II transforming growth factor beta receptor binding GO:0005114 9.26 TGFB3 ENG
7 growth factor activity GO:0008083 9.26 VEGFA TGFB3 FGF2 BMP6
8 transmembrane signaling receptor activity GO:0004888 9.02 TLR9 TLR7 TLR3 PECAM1 ENG

Sources for Juvenile Nasopharyngeal Angiofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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