MCID: JVN058
MIFTS: 21

Juvenile-Onset Parkinson's Disease

Categories: Neuronal diseases, Genetic diseases, Rare diseases, Mental diseases, Metabolic diseases

Aliases & Classifications for Juvenile-Onset Parkinson's Disease

MalaCards integrated aliases for Juvenile-Onset Parkinson's Disease:

Name: Juvenile-Onset Parkinson's Disease 12
Juvenile-Onset Parkinson Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060893

Summaries for Juvenile-Onset Parkinson's Disease

MalaCards based summary : Juvenile-Onset Parkinson's Disease, also known as juvenile-onset parkinson disease, is related to kufor-rakeb syndrome and parkinson disease 19a, juvenile-onset. An important gene associated with Juvenile-Onset Parkinson's Disease is DNAJC6 (DnaJ Heat Shock Protein Family (Hsp40) Member C6), and among its related pathways/superpathways are Cardiac conduction and Ion channel transport.

Related Diseases for Juvenile-Onset Parkinson's Disease

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease Early-Onset Parkinson's Disease
Lrrk2-Related Parkinson Disease Vps35-Related Parkinson Disease
Parkinson Disease Type 9 Hereditary Late-Onset Parkinson Disease

Diseases related to Juvenile-Onset Parkinson's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 kufor-rakeb syndrome 27.5 ATP13A1 ATP13A2 ATP13A5 ATP1B4 FBXO7 PLA2G6
2 parkinson disease 19a, juvenile-onset 11.5
3 parkinson disease, late-onset 11.1
4 neurodegeneration with brain iron accumulation 9.7 ATP13A2 PLA2G6
5 neurodegeneration with brain iron accumulation 2b 9.7 FBXO7 PLA2G6
6 aceruloplasminemia 9.5 ATP13A2 PLA2G6
7 parkinson disease 15, autosomal recessive early-onset 9.3 ATP13A2 FBXO7 PLA2G6
8 neurodegeneration with brain iron accumulation 2a 9.3 ATP13A2 FBXO7 PLA2G6

Graphical network of the top 20 diseases related to Juvenile-Onset Parkinson's Disease:



Diseases related to Juvenile-Onset Parkinson's Disease

Symptoms & Phenotypes for Juvenile-Onset Parkinson's Disease

Drugs & Therapeutics for Juvenile-Onset Parkinson's Disease

Search Clinical Trials , NIH Clinical Center for Juvenile-Onset Parkinson's Disease

Genetic Tests for Juvenile-Onset Parkinson's Disease

Anatomical Context for Juvenile-Onset Parkinson's Disease

Publications for Juvenile-Onset Parkinson's Disease

Articles related to Juvenile-Onset Parkinson's Disease:

# Title Authors Year
1
A novel nonsense mutation in DNAJC6 expands the phenotype of autosomal-recessive juvenile-onset Parkinson's disease. ( 26703368 )
2016
2
Juvenile onset Parkinson's disease. ( 3825691 )
1987

Variations for Juvenile-Onset Parkinson's Disease

Expression for Juvenile-Onset Parkinson's Disease

Search GEO for disease gene expression data for Juvenile-Onset Parkinson's Disease.

Pathways for Juvenile-Onset Parkinson's Disease

GO Terms for Juvenile-Onset Parkinson's Disease

Cellular components related to Juvenile-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.26 ATP13A1 ATP13A2 ATP13A5 ATP1B4
2 intracellular membrane-bounded organelle GO:0043231 8.92 ATP13A1 ATP13A2 ATP13A5 DNAJC6

Biological processes related to Juvenile-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.5 ATP13A1 ATP13A2 ATP13A5
2 calcium ion transmembrane transport GO:0070588 9.43 ATP13A1 ATP13A2 ATP13A5
3 negative regulation of neuron death GO:1901215 9.37 ATP13A2 FBXO7
4 cellular calcium ion homeostasis GO:0006874 9.33 ATP13A1 ATP13A2 ATP13A5
5 cation transport GO:0006812 9.13 ATP13A1 ATP13A2 ATP13A5
6 ATP hydrolysis coupled cation transmembrane transport GO:0099132 8.8 ATP13A1 ATP13A2 ATP13A5

Molecular functions related to Juvenile-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.55 ATP13A1 ATP13A2 ATP13A5 DNAJC6 PLA2G6
2 ATPase activity GO:0016887 9.43 ATP13A1 ATP13A2 ATP13A5
3 cation-transporting ATPase activity GO:0019829 9.13 ATP13A1 ATP13A2 ATP13A5
4 calcium-transporting ATPase activity GO:0005388 8.8 ATP13A1 ATP13A2 ATP13A5

Sources for Juvenile-Onset Parkinson's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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