MCID: JVN058
MIFTS: 23

Juvenile-Onset Parkinson's Disease

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Juvenile-Onset Parkinson's Disease

MalaCards integrated aliases for Juvenile-Onset Parkinson's Disease:

Name: Juvenile-Onset Parkinson's Disease 12 15
Juvenile-Onset Parkinson Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060893

Summaries for Juvenile-Onset Parkinson's Disease

MalaCards based summary : Juvenile-Onset Parkinson's Disease, also known as juvenile-onset parkinson disease, is related to kufor-rakeb syndrome and parkinson disease 19a, juvenile-onset. An important gene associated with Juvenile-Onset Parkinson's Disease is DNAJC6 (DnaJ Heat Shock Protein Family (Hsp40) Member C6), and among its related pathways/superpathways are Cardiac conduction and Ion channel transport. Affiliated tissues include brain.

Related Diseases for Juvenile-Onset Parkinson's Disease

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease Early-Onset Parkinson's Disease
Lrrk2-Related Parkinson Disease Vps35-Related Parkinson Disease
Parkinson Disease Type 9 Hereditary Late-Onset Parkinson Disease

Diseases related to Juvenile-Onset Parkinson's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 kufor-rakeb syndrome 30.7 ATP13A1 ATP13A2 ATP13A5 FBXO7 PLA2G6
2 parkinson disease 19a, juvenile-onset 11.8
3 parkinson disease, late-onset 11.6
4 blepharitis 10.0 CRYAA PLA2G6
5 neurodegeneration with brain iron accumulation 2a 9.9 FA2H PLA2G6
6 spinocerebellar ataxia, autosomal recessive 21 9.9 ATP13A2 FA2H
7 neurodegeneration with brain iron accumulation 3 9.9 FA2H PLA2G6
8 neuroaxonal dystrophy 9.9 FA2H PLA2G6
9 spastic paraplegia 73, autosomal dominant 9.9 ATP13A2 FA2H
10 early-onset parkinson's disease 9.9 ATP13A2 DNAJC6
11 neurodegeneration with brain iron accumulation 1 9.9 FA2H PLA2G6
12 parkinson disease 15, autosomal recessive early-onset 9.8 ATP13A2 FBXO7 PLA2G6
13 spastic paraplegia 76, autosomal recessive 9.8 ATP13A2 FA2H
14 neurodegeneration with brain iron accumulation 9.7 ATP13A2 FA2H PLA2G6
15 aceruloplasminemia 9.7 ATP13A2 FA2H PLA2G6
16 neurodegeneration with brain iron accumulation 2b 9.7 FA2H FBXO7 PLA2G6
17 hereditary spastic paraplegia 9.7 ATP13A2 FA2H PLA2G6

Graphical network of the top 20 diseases related to Juvenile-Onset Parkinson's Disease:



Diseases related to Juvenile-Onset Parkinson's Disease

Symptoms & Phenotypes for Juvenile-Onset Parkinson's Disease

Drugs & Therapeutics for Juvenile-Onset Parkinson's Disease

Search Clinical Trials , NIH Clinical Center for Juvenile-Onset Parkinson's Disease

Genetic Tests for Juvenile-Onset Parkinson's Disease

Anatomical Context for Juvenile-Onset Parkinson's Disease

MalaCards organs/tissues related to Juvenile-Onset Parkinson's Disease:

42
Brain

Publications for Juvenile-Onset Parkinson's Disease

Articles related to Juvenile-Onset Parkinson's Disease:

# Title Authors Year
1
A Novel Nonsense Mutation in DNAJC6 Expands the Phenotype of Autosomal-Recessive Juvenile-Onset Parkinson's Disease. ( 26703368 )
2016
2
Juvenile onset Parkinson's disease. ( 3825691 )
1987

Variations for Juvenile-Onset Parkinson's Disease

Expression for Juvenile-Onset Parkinson's Disease

Search GEO for disease gene expression data for Juvenile-Onset Parkinson's Disease.

Pathways for Juvenile-Onset Parkinson's Disease

GO Terms for Juvenile-Onset Parkinson's Disease

Biological processes related to Juvenile-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.43 ATP13A1 ATP13A2 ATP13A5
2 cellular calcium ion homeostasis GO:0006874 9.33 ATP13A1 ATP13A2 ATP13A5
3 negative regulation of neuron death GO:1901215 9.32 ATP13A2 FBXO7
4 cation transport GO:0006812 9.13 ATP13A1 ATP13A2 ATP13A5
5 ATP hydrolysis coupled cation transmembrane transport GO:0099132 8.62 ATP13A1 ATP13A2

Molecular functions related to Juvenile-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.55 ATP13A1 ATP13A2 ATP13A5 DNAJC6 PLA2G6
2 ATPase activity GO:0016887 9.13 ATP13A1 ATP13A2 ATP13A5
3 cation-transporting ATPase activity GO:0019829 8.32 ATP13A2

Sources for Juvenile-Onset Parkinson's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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