MCID: JVN045
MIFTS: 16

Juvenile Ossifying Fibroma

Categories: Bone diseases, Cancer diseases, Oral diseases, Rare diseases

Aliases & Classifications for Juvenile Ossifying Fibroma

MalaCards integrated aliases for Juvenile Ossifying Fibroma:

Name: Juvenile Ossifying Fibroma 20 70

Classifications:



External Ids:

UMLS 70 C0457522

Summaries for Juvenile Ossifying Fibroma

GARD : 20 Juvenile ossifying fibroma (JOF) is rare, benign tumor of the craniofacial (skull and face) bones. It is considered a "fibro-osseous neoplasm " because it is characterized by an overgrowth of bone. Affected people generally experience a gradual or rapid, painless expansion of the affected bone or region. Other symptoms such as exophthalmos or nasal blockage can rarely be associated with the tumor depending on its exact location. In some cases, the condition can be particularly aggressive with rapid growth and significant facial disfigurement. Although the condition can affect people of all ages, it is most commonly diagnosed between the ages of 5 and 15. The exact underlying cause is currently unknown; however, most cases occur sporadically in people with no family history of the condition. JOF is usually treated with surgery. Because the recurrence rate of JOF ranges from 30% to 58%, continued follow-up is essential.

MalaCards based summary : Juvenile Ossifying Fibroma is related to ossifying fibroma and fibroma. An important gene associated with Juvenile Ossifying Fibroma is MDM2 (MDM2 Proto-Oncogene). Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Juvenile Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 ossifying fibroma 30.8 RASAL1 MDM2
2 fibroma 11.1
3 fibrous dysplasia 10.6
4 aneurysmal bone cysts 10.5
5 osteogenic sarcoma 10.4
6 exophthalmos 10.4
7 osteoblastoma 10.3
8 root resorption 10.2
9 burkitt lymphoma 10.1
10 cherubism 10.1
11 hypertelorism 10.1
12 yemenite deaf-blind hypopigmentation syndrome 10.1
13 meningioma, familial 10.1
14 osteofibrous dysplasia 10.1
15 dedifferentiated liposarcoma 10.1
16 intracranial meningioma 10.1
17 hyperparathyroidism 10.1
18 giant cell reparative granuloma 10.1
19 liposarcoma 10.1
20 secretory meningioma 10.1
21 lymphoplasmacyte-rich meningioma 10.1
22 back pain 10.1

Graphical network of the top 20 diseases related to Juvenile Ossifying Fibroma:



Diseases related to Juvenile Ossifying Fibroma

Symptoms & Phenotypes for Juvenile Ossifying Fibroma

GenomeRNAi Phenotypes related to Juvenile Ossifying Fibroma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.55 RASAL1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.55 RASAL1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.55 MDM2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.55 MDM2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.55 RASAL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.55 MDM2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.55 MDM2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.55 RASAL1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.55 MDM2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.55 MDM2 RASAL1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.55 RASAL1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.55 RASAL1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.55 RASAL1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.55 MDM2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.55 RASAL1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.55 RASAL1

Drugs & Therapeutics for Juvenile Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Juvenile Ossifying Fibroma

Genetic Tests for Juvenile Ossifying Fibroma

Anatomical Context for Juvenile Ossifying Fibroma

Publications for Juvenile Ossifying Fibroma

Articles related to Juvenile Ossifying Fibroma:

(show top 50) (show all 151)
# Title Authors PMID Year
1
Juvenile Psammomatoid Cemeto-ossifying Fibroma of Mandible: a Diagnostic dilemma. 61
33741572 2021
2
Entirely endoscopic resection of a complicated juvenile psammomatoid ossifying fibroma of the paranasal sinusitis: Case report and review of the literature. 61
33743250 2021
3
Cemento-ossifying fibroma and juvenile ossifying fibroma: Clarity in terminology. 61
33129707 2021
4
Rare case of juvenile ossifying fibroma of the lumbar spine causing vertebra plana. 61
33462042 2021
5
Primary Bone Tumors in North of Jordan. 61
33605114 2020
6
Endoscopic Optic Nerve Decompression for Optic Neuropathy in Sinonasal Fibro-Osseous Tumors. 61
32105872 2020
7
Intraoral Approach for Surgical Treatment of Psammomatoid Juvenile Ossifying Fibroma. 61
31934971 2020
8
Massive juvenile ossifying fibroma arising from the middle turbinate. 61
32295801 2020
9
Oral and Extraoral Intermediate Tumors: Are MMP-9 and Ki-67 Biomarkers Correlated to Their High Recurrence Rates? 61
30358613 2020
10
Juvenile ossifying fibroma of the jaws and paranasal sinuses: a systematic review of the cases reported in the literature. 61
31285096 2020
11
Simultaneous presentation of juvenile ossifying fibroma in the maxilla and mandible: a case report. 61
32480339 2020
12
Reconstruction and Mandibular Rehabilitation After Resection of Juvenile Aggressive Ossifying Fibroma Using Undifferentiated Mesenchymal Cells and Osseointegrated Implants: A Case Report. 61
31107685 2019
13
Craniofacial Approaches to Pediatric Orbital Tumors. 61
30865111 2019
14
Juvenile ossifying fibroma in a Nigerian boy: a rare case report. 61
31380504 2019
15
Two-stage surgical treatment for a giant sellar psammomatoid juvenile ossifying fibroma: case report. 61
30611151 2019
16
Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma. 61
31632653 2019
17
Management of an extensive equine juvenile ossifying fibroma by rostral mandibulectomy and reconstruction of the mandibular symphysis using String of Pearls plates with cortical and cancellous bone autografts. 61
30370537 2019
18
Juvenile Trabecular Ossifying Fibroma. 61
29027609 2018
19
Microvessel density and cell proliferation in juvenile ossifying fibroma: A comparative study with central ossifying fibroma. 61
30098514 2018
20
Juvenile Ossifying Fibroma of Maxilla. 61
31719318 2018
21
Psammomatoid variant of juvenile ossifying fibroma. 61
30004078 2018
22
Recurrent juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of the maxilla: a case report and review of literature. 61
30090219 2018
23
Rare case of a recurrent juvenile ossifying fibroma of the lumbosacral spine. 61
29521580 2018
24
Juvenile Trabecular Ossifying Fibroma-a Case Report. 61
29887713 2018
25
Fibro-Osseous Lesions of the Skull Base in the Pediatric Population. 61
29404238 2018
26
Corrigendum to "Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma". 61
29992060 2018
27
Juvenile Ossifying Fibroma in the Mandible. 61
29963444 2018
28
Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation. 61
29184270 2017
29
Cherubism. A case report. 61
27427211 2017
30
Psammomatoid Juvenile Ossifying Fibroma: Report of Three Cases with a Review of Literature. 61
29675079 2017
31
Costal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. 61
28642188 2017
32
Trabecular Variant Juvenile Ossifying Fibroma of the Maxilla. 61
29152441 2017
33
Radiotherapy for juvenile ossifying fibroma of the maxillary sinus: Case report and literature review. 61
28467645 2017
34
Conglomeration of Trabecular and Psammomatoid variants of juvenile ossifying fibroma - a rare case report. 61
28588818 2017
35
Denosumab-treated giant cell tumor of bone. Its histologic spectrum and potential diagnostic pitfalls. 61
28235628 2017
36
Non-odontogenic tumors of the facial bones in children and adolescents: role of multiparametric imaging. 61
28289810 2017
37
Epithelioid osteoblastoma: A histopathological dilemma between juvenile ossifying fibroma and low-grade osteosarcoma. 61
28479709 2017
38
Psammomatoid Juvenile Ossifying Fibroma of Mandible in a 41-Year Male Patient. 61
28292370 2017
39
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Proximal Radius: A Rare Entity. 61
28932332 2017
40
Trabecular Variant: A Rare Entity of Juvenile Ossifying Fibroma of the Mandible. 61
28566876 2017
41
Juvenile Trabecular Ossifying Fibroma of the Maxilla: a Case Report. 61
28210024 2016
42
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. 61
27513775 2016
43
Polyostotic Juvenile Ossifying Fibroma: An Exceptionally Rare Case. 61
26068381 2016
44
A new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification. 61
26997440 2016
45
Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases. 61
26740351 2016
46
Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants. 61
26900747 2016
47
Psammomatoid juvenile ossifying fibroma of mandible in a 6-year-old child. 61
27134454 2016
48
Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma. 61
28101383 2016
49
Psammomatoid variant of juvenile ossifying fibroma involving mandible: A rare case report. 61
26681872 2015
50
Management and Treatment Outcomes of Maxillofacial Fibro-osseous Lesions: A Retrospective Study. 61
26225069 2015

Variations for Juvenile Ossifying Fibroma

Expression for Juvenile Ossifying Fibroma

Search GEO for disease gene expression data for Juvenile Ossifying Fibroma.

Pathways for Juvenile Ossifying Fibroma

GO Terms for Juvenile Ossifying Fibroma

Sources for Juvenile Ossifying Fibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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