MCID: JVN045
MIFTS: 17

Juvenile Ossifying Fibroma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Juvenile Ossifying Fibroma

MalaCards integrated aliases for Juvenile Ossifying Fibroma:

Name: Juvenile Ossifying Fibroma 53 73

Classifications:



External Ids:

UMLS 73 C0457522

Summaries for Juvenile Ossifying Fibroma

NIH Rare Diseases : 53 Juvenile ossifying fibroma (JOF) is rare, benign tumor of the craniofacial (skull and face) bones. It is considered a "fibro-osseous neoplasm" because it is characterized by an overgrowth of bone. Affected people generally experience a gradual or rapid, painless expansion of the affected bone or region. Other symptoms such as exophthalmos or nasal blockage can rarely be associated with the tumor depending on its exact location. In some cases, the condition can be particularly aggressive with rapid growth and significant facial disfigurement. Although the condition can affect people of all ages, it is most commonly diagnosed between the ages of 5 and 15. The exact underlying cause is currently unknown; however, most cases occur sporadically in people with no family history of the condition. JOF is usually treated with surgery. Because the recurrence rate of JOF ranges from 30% to 58%, continued follow-up is essential.

MalaCards based summary : Juvenile Ossifying Fibroma is related to ossifying fibroma and fibrous dysplasia. An important gene associated with Juvenile Ossifying Fibroma is MDM2 (MDM2 Proto-Oncogene). Affiliated tissues include bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Juvenile Ossifying Fibroma

Diseases in the Ossifying Fibroma family:

Juvenile Ossifying Fibroma

Diseases related to Juvenile Ossifying Fibroma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ossifying fibroma 31.2 MDM2 RASAL1
2 fibrous dysplasia 10.2
3 osteoblastoma 10.1
4 connective tissue benign neoplasm 9.7 MDM2 RASAL1

Symptoms & Phenotypes for Juvenile Ossifying Fibroma

GenomeRNAi Phenotypes related to Juvenile Ossifying Fibroma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.58 RASAL1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.58 RASAL1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.58 MDM2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.58 MDM2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.58 RASAL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.58 MDM2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.58 MDM2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.58 RASAL1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.58 MDM2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.58 RASAL1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.58 RASAL1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.58 MDM2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 MDM2 RASAL1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 RASAL1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.58 RASAL1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.58 MDM2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.58 RASAL1

Drugs & Therapeutics for Juvenile Ossifying Fibroma

Search Clinical Trials , NIH Clinical Center for Juvenile Ossifying Fibroma

Genetic Tests for Juvenile Ossifying Fibroma

Anatomical Context for Juvenile Ossifying Fibroma

MalaCards organs/tissues related to Juvenile Ossifying Fibroma:

41
Bone

Publications for Juvenile Ossifying Fibroma

Articles related to Juvenile Ossifying Fibroma:

(show top 50) (show all 83)
# Title Authors Year
1
Rare case of a recurrent juvenile ossifying fibroma of the lumbosacral spine. ( 29521580 )
2018
2
Juvenile Ossifying Fibroma in the Mandible. ( 29963444 )
2018
3
Corrigendum to "Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma". ( 29992060 )
2018
4
Psammomatoid variant of juvenile ossifying fibroma. ( 30004078 )
2018
5
Microvessel density and cell proliferation in juvenile ossifying fibroma: A comparative study with central ossifying fibroma. ( 30098514 )
2018
6
Management of an extensive equine juvenile ossifying fibroma by rostral mandibulectomy and reconstruction of the mandibular symphysis using String of Pearls plates with cortical and cancellous bone autografts. ( 30370537 )
2018
7
Psammomatoid Juvenile Ossifying Fibroma of Mandible in a 41-Year Male Patient. ( 28292370 )
2017
8
Costal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. ( 28642188 )
2017
9
Trabecular Variant: A Rare Entity of Juvenile Ossifying Fibroma of the Mandible. ( 28566876 )
2017
10
Epithelioid osteoblastoma: A histopathological dilemma between juvenile ossifying fibroma and low-grade osteosarcoma. ( 28479709 )
2017
11
Trabecular Variant Juvenile Ossifying Fibroma of the Maxilla. ( 29152441 )
2017
12
Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation. ( 29184270 )
2017
13
Radiotherapy for juvenile ossifying fibroma of the maxillary sinus: Case report and literature review. ( 28467645 )
2017
14
Psammomatoid Juvenile Ossifying Fibroma: Report of Three Cases with a Review of Literature. ( 29675079 )
2017
15
Conglomeration of Trabecular and Psammomatoid variants of juvenile ossifying fibroma - a rare case report. ( 28588818 )
2017
16
Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma. ( 28101383 )
2016
17
Juvenile ossifying fibroma of the jaw: a retrospective study of 15 cases. ( 26740351 )
2016
18
Psammomatoid juvenile ossifying fibroma of mandible in a 6-year-old child. ( 27134454 )
2016
19
Le Fort I Disassembly for the Management of Juvenile Ossifying Fibroma Extending To the Skull Base. ( 27513775 )
2016
20
Juvenile ossifying fibroma of the maxilla: a case report. ( 25838672 )
2015
21
Juvenile ossifying fibroma diagnosed on fine needle aspiration cytology: a diagnostic challenge. ( 24591292 )
2015
22
Is Computed Tomography an Adequate Imaging Modality for the Evaluation of Juvenile Ossifying Fibroma? A Comparison of 2 Imaging Modalities (Computed Tomography and Magnetic Resonance Imaging). ( 25911216 )
2015
23
Polyostotic Juvenile Ossifying Fibroma: An Exceptionally Rare Case. ( 26068381 )
2015
24
Psammomatoid Juvenile Ossifying Fibroma Involving Upper Jaw: A Rare Case Report. ( 26393222 )
2015
25
Intranasal endoscopic prelacrimal recess approach to sinonasal juvenile ossifying fibroma. ( 25635449 )
2015
26
Psammomatoid variant of juvenile ossifying fibroma involving mandible: A rare case report. ( 26681872 )
2015
27
Juvenile ossifying fibroma with aneurysamal bone cyst: a case report. ( 25478458 )
2014
28
Psammomatoid Juvenile Ossifying Fibroma of the Maxilla: Radical Surgery with Maxillary Resection in a 7-year-old Girl. ( 24449425 )
2014
29
Juvenile ossifying fibroma of the middle turbinate. ( 25075725 )
2014
30
Chromosome 12 long arm rearrangement covering MDM2 and RASAL1 is associated with aggressive craniofacial juvenile ossifying fibroma and extracranial psammomatoid fibro-osseous lesions. ( 24925056 )
2014
31
Minimally invasive endoscopic removal of a massive trabecular juvenile ossifying fibroma of the paranasal sinuses. ( 25129190 )
2014
32
Psammomatoid and trabecular juvenile ossifying fibroma: two distinct radiologic entities. ( 25457891 )
2014
33
Clinicopathologic and radiologic correlation of ossifying fibroma and juvenile ossifying fibroma--an institutional study of 22 cases. ( 22841475 )
2013
34
Juvenile ossifying fibroma of mandible: a case report. ( 24431886 )
2013
35
Case report: Trabecular juvenile ossifying fibroma presenting as a sellar mass. ( 22777925 )
2013
36
A massive sinonasal psammomatoid variant of juvenile ossifying fibroma: Report of a rare entity. ( 24250099 )
2013
37
Psammomatoid type juvenile ossifying fibroma of mandible. ( 23662272 )
2013
38
Juvenile ossifying fibroma of paranasal sinuses-do we need to be radical in surgery? ( 23714983 )
2013
39
Psammomatoid Juvenile Ossifying Fibroma of the Maxilla: Radical Surgery with Maxillary Resection in a 7-year-old Girl. ( 24166092 )
2013
40
Psammomatoid juvenile ossifying fibroma: case study and a review. ( 23435579 )
2013
41
Rare pediatric presentation of aneurysmal bone cyst with trabecular juvenile ossifying fibroma and ossifying fibroma. ( 23305772 )
2013
42
Juvenile ossifying fibroma of the maxilla: a rare aggressive case in a young patient. ( 23771389 )
2013
43
Psammomatoid juvenile ossifying fibroma: an analysis of 2 cases affecting the mandible with review of the literature. ( 22668716 )
2012
44
Juvenile ossifying fibroma: Psammamatoid variant. ( 23293493 )
2012
45
Juvenile ossifying fibroma of the maxilla. ( 21596643 )
2011
46
Intraoral sublabial approach for anterior skull base juvenile ossifying fibroma. ( 21959488 )
2011
47
Rapidly maturing juvenile ossifying fibroma: a case report. ( 21346088 )
2011
48
Psammomatoid juvenile ossifying fibroma of the jaws. ( 22144839 )
2011
49
Trabecular juvenile ossifying fibroma with aneurysmal bone cyst: a rare presentation. ( 22104705 )
2011
50
General practitioner's radiology case 96. Juvenile ossifying fibroma. ( 23477273 )
2011

Variations for Juvenile Ossifying Fibroma

Expression for Juvenile Ossifying Fibroma

Search GEO for disease gene expression data for Juvenile Ossifying Fibroma.

Pathways for Juvenile Ossifying Fibroma

GO Terms for Juvenile Ossifying Fibroma

Sources for Juvenile Ossifying Fibroma

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74 UMLS via Orphanet
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