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MCID: JVN009
MIFTS: 47

Juvenile Pilocytic Astrocytoma

Categories: Cancer diseases, Rare diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Juvenile Pilocytic Astrocytoma

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MalaCards integrated aliases for Juvenile Pilocytic Astrocytoma:

Name: Juvenile Pilocytic Astrocytoma 12 55 15 73

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6811
MeSH 44 D001254
NCIt 50 C27081
UMLS 73 C0280783
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Summaries for Juvenile Pilocytic Astrocytoma

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MalaCards based summary : Juvenile Pilocytic Astrocytoma is related to pilocytic astrocytoma and glioma, and has symptoms including headache An important gene associated with Juvenile Pilocytic Astrocytoma is TIMP3 (TIMP Metallopeptidase Inhibitor 3), and among its related pathways/superpathways are ERK Signaling and Glioma. The drugs Vincristine and Procarbazine have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are cellular and behavior/neurological

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Related Diseases for Juvenile Pilocytic Astrocytoma

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Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Juvenile Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 32.5 CDKN2A FGF2 GFAP NF1 TIMP3 TP53
2 glioma 29.7 CDKN2A FGF2 NF1 TNC TP53
3 glioblastoma multiforme 29.1 CD44 CDKN2A GFAP TP53
4 oligodendroglioma 28.6 CDKN2A ENO2 GFAP MBP TP53
5 medulloblastoma 28.6 DDX3X ENO2 GFAP MAP2K1 TIMP3 TP53
6 astrocytoma 10.8
7 childhood pilocytic astrocytoma 10.8 NF1 NTM
8 brain stem astrocytic neoplasm 10.7 CDKN2A TP53
9 frontal convexity meningioma 10.7 GFAP TP53
10 cornea cancer 10.6 FGF2 GFAP
11 splenic diffuse red pulp small b-cell lymphoma 10.6 MAP2K1 TP53
12 cerebral convexity meningioma 10.6 GFAP TP53
13 protoplasmic astrocytoma 10.6 GFAP TP53
14 keratinizing squamous cell carcinoma 10.6 CDKN2A TP53
15 cellular ependymoma 10.6 GFAP TP53
16 spitz nevus 10.5 CDKN2A TP53
17 vulvar dystrophy 10.5 CDKN2A MBP
18 bladder squamous cell carcinoma 10.5 CDKN2A FGF2 TP53
19 actinic keratosis 10.4 CDKN2A TNC TP53
20 endometrial adenocarcinoma 10.4 CDKN2A FGF2 TP53
21 duodenal somatostatinoma 10.4 ENO2 NF1
22 epithelioid malignant peripheral nerve sheath tumor 10.4 ENO2 NF1
23 anaplastic oligodendroglioma 10.4 CDKN2A GFAP
24 gliofibroma 10.4 GFAP NF1 TP53
25 cellular schwannoma 10.4 CDKN2A NF1 TP53
26 mixed glioma 10.4 GFAP TP53
27 bladder carcinoma in situ 10.4 CDKN2A TP53
28 intracranial cysts 10.4 ENO2 GFAP
29 spinal cancer 10.4 GFAP TP53
30 bartholin's gland benign neoplasm 10.3 CDKN2A TP53
31 atypical follicular adenoma 10.3 ENO2 TP53
32 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 GFAP
33 malignant peripheral nerve sheath tumor 10.3 CDKN2A NF1 TP53
34 vulva squamous cell carcinoma 10.3 CDKN2A TP53
35 melanotic medulloblastoma 10.3 ENO2 GFAP
36 li-fraumeni syndrome 10.3 CDKN2A NF1 TP53
37 cerebellum cancer 10.3 ENO2 TP53
38 atypical neurofibroma 10.3 CDKN2A GFAP NF1
39 connective tissue cancer 10.3 ENO2 FGF2 TP53
40 finger agnosia 10.3 ENO2 MBP
41 necrotizing sialometaplasia 10.2 CDKN2A GFAP TP53
42 neonatal hypoxic and ischemic brain injury 10.2 ENO2 MBP
43 chiari malformation 10.2 GFAP MBP
44 cerebellar medulloblastoma 10.2 ENO2 GFAP
45 organ system benign neoplasm 10.2 ENO2 NF1 TP53
46 peripheral nervous system neoplasm 10.2 ENO2 NF1 TP53
47 grade iii astrocytoma 10.2 CDKN2A GFAP TP53
48 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
49 ependymoblastoma 10.2 GFAP TP53
50 chordoma 10.2 CDKN2A GFAP TP53

Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to Juvenile Pilocytic Astrocytoma
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Symptoms & Phenotypes for Juvenile Pilocytic Astrocytoma

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UMLS symptoms related to Juvenile Pilocytic Astrocytoma:


headache

MGI Mouse Phenotypes related to Juvenile Pilocytic Astrocytoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 FGF2 GFAP INSR MAP2K1 MBP NF1
2 behavior/neurological MP:0005386 10.35 CD44 CDKN2A ENO2 FGF2 GFAP INSR
3 cardiovascular system MP:0005385 10.3 CD44 CDKN2A DDX3X FGF2 GFAP INSR
4 growth/size/body region MP:0005378 10.3 DDX3X ENO2 GFAP INSR MAP2K1 MBP
5 homeostasis/metabolism MP:0005376 10.29 CD44 CDKN2A DDX3X FGF2 GFAP INSR
6 hematopoietic system MP:0005397 10.19 CD276 CD44 CDKN2A FGF2 INSR MBP
7 mortality/aging MP:0010768 10.18 CD44 CDKN2A DDX3X FGF2 GFAP TP53
8 immune system MP:0005387 10.16 CD276 CD44 CDKN2A GFAP INSR MBP
9 digestive/alimentary MP:0005381 10.08 CD44 CDKN2A GFAP INSR MAP2K1 NF1
10 muscle MP:0005369 10.07 CD44 CDKN2A DDX3X FGF2 GFAP INSR
11 nervous system MP:0003631 10.07 CD44 CDKN2A DDX3X ENO2 FGF2 GFAP
12 hearing/vestibular/ear MP:0005377 9.99 FGF2 MAP2K1 MBP NF1 TNC TP53
13 liver/biliary system MP:0005370 9.98 CD44 CDKN2A INSR NF1 TIMP3 TP53
14 neoplasm MP:0002006 9.8 CD44 CDKN2A FGF2 MAP2K1 NF1 TP53
15 normal MP:0002873 9.76 GFAP MAP2K1 MBP NF1 TNC TP53
16 respiratory system MP:0005388 9.5 CD44 CDKN2A ENO2 INSR NF1 TIMP3
17 vision/eye MP:0005391 9.32 CD44 CDKN2A FGF2 GFAP MAP2K1 MBP
Sources

Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

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Drugs for Juvenile Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 2, Phase 3,Phase 1 2068-78-2, 57-22-7 5978
2
Procarbazine Approved, Investigational Phase 2, Phase 3 671-16-9 4915
3
Lomustine Approved, Investigational Phase 2, Phase 3 13010-47-4 3950
4
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
Dopamine Approved Phase 3,Not Applicable 51-61-6, 62-31-7 681
7
Cyproheptadine Approved Phase 3 129-03-3 2913
8
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
9
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
10 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
11 Alkylating Agents Phase 2, Phase 3,Phase 1
12 Dermatologic Agents Phase 3,Phase 2,Phase 1
13 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 1
14 Analgesics Phase 3
15 Central Nervous System Depressants Phase 3
16 Adjuvants, Anesthesia Phase 3
17 Central Nervous System Stimulants Phase 3,Phase 2
18 Cholinergic Agents Phase 3,Phase 2
19 Cholinesterase Inhibitors Phase 3,Phase 2
20 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
21 Narcotics Phase 3
22 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
23 Analgesics, Opioid Phase 3
24 Anesthetics Phase 3
25 Nootropic Agents Phase 3,Phase 2
26 Anesthetics, General Phase 3
27 Anesthetics, Intravenous Phase 3
28 Peripheral Nervous System Agents Phase 3
29 Liver Extracts Phase 3,Phase 2,Phase 1
30 Antimitotic Agents Phase 2, Phase 3,Phase 1
31 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 1
32 Dopamine Agents Phase 3,Not Applicable
33
Histamine Phosphate Phase 3 51-74-1 65513
34 Serotonin Agents Phase 3
35 Serotonin Antagonists Phase 3
36 Histamine Antagonists Phase 3
37 Histamine H1 Antagonists Phase 3
38 Neurotransmitter Uptake Inhibitors Phase 3
39 Dexmethylphenidate Hydrochloride Phase 3
40 Anti-Allergic Agents Phase 3
41 Dopamine Uptake Inhibitors Phase 3
42 Antipruritics Phase 3
43 Cola Nutraceutical Phase 3,Phase 1
44
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
45
Dacarbazine Approved, Investigational Phase 2,Phase 1 4342-03-4 5351166
46
Temozolomide Approved, Investigational Phase 2,Phase 1 85622-93-1 5394
47
Trioxsalen Approved Phase 2,Phase 1 3902-71-4 5585
48
Cisplatin Approved Phase 2,Phase 1 15663-27-1 84093 441203 2767
49
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
50
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma Completed NCT00003375 Phase 2, Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
6 Temozolomide in Treating Patients With Low-Grade Glioma Completed NCT00313729 Phase 2 temozolomide
7 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2 erlotinib;temsirolimus
8 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
9 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
10 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
11 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
12 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
13 Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas Completed NCT00274755 Phase 2 chemotherapy
14 Imatinib Mesylate in Treating Patients With Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
15 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2 gefitinib
16 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
17 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
18 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2 imatinib mesylate
19 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
20 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
21 Phase II Pegylated Interferon Recruiting NCT02343224 Phase 2 Pegylated interferon alpha-2b
22 Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Recruiting NCT01089101 Phase 1, Phase 2 Selumetinib
23 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
24 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib;Carboplatin with vincristine
25 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Active, not recruiting NCT01553149 Phase 2 Lenalidomide
26 Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Active, not recruiting NCT01966809 Phase 2 Photofrin photodynamic therapy.
27 Bevacizumab in Recurrent Grade II and III Glioma Active, not recruiting NCT01164189 Phase 2 Temozolomide
28 Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Active, not recruiting NCT00553150 Phase 1, Phase 2 everolimus;temozolomide
29 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
30 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
31 Functional Magnetic Resonance Imaging and 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Treating Patients With Newly Diagnosed Brain Tumors Withdrawn NCT00005083 Phase 2
32 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
33 Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas Unknown status NCT00083096 Phase 1 lonafarnib;temozolomide
34 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
35 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
36 Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma Completed NCT00730613 Phase 1
37 Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers Completed NCT00498979 Phase 1 cisplatin;sodium stibogluconate;dacarbazine;vinblastine
38 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
39 Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00509431 Phase 1 Erlotinib + Sirolimus
40 Tumor Tissue Analysis in Patients Receiving Imatinib Mesylate for Malignant Glioma Completed NCT00401024 Phase 1 imatinib mesylate
41 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
42 BCX-1777 in Treating Patients With Refractory Cancer Completed NCT00073944 Phase 1 forodesine hydrochloride
43 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
44 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
45 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
46 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
47 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
48 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
49 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
50 Cognitive Biomarkers in Pediatric Brain Tumor Patients Recruiting NCT02914067 Phase 1

Search NIH Clinical Center for Juvenile Pilocytic Astrocytoma

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Genetic Tests for Juvenile Pilocytic Astrocytoma

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Anatomical Context for Juvenile Pilocytic Astrocytoma

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MalaCards organs/tissues related to Juvenile Pilocytic Astrocytoma:

41
Brain, Liver, Bone, Kidney, Spinal Cord, Pituitary, Pineal
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Publications for Juvenile Pilocytic Astrocytoma

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Articles related to Juvenile Pilocytic Astrocytoma:

(show top 50) (show all 51)
# Title Authors Year
1
Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children. ( 29125440 )
2018
2
Circulating serum oncologic miRNA in pediatric juvenile pilocytic astrocytoma patients predicts mural nodule volume. ( 29911246 )
2018
3
Resection of a Pediatric Thalamic Juvenile Pilocytic Astrocytoma with Whole Brain Tractography. ( 29234572 )
2017
4
Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. ( 27314542 )
2016
5
Spontaneous aneurysmal subarachnoid haemorrhage in a child with multiply recurrent posterior fossa juvenile pilocytic astrocytoma. ( 27927709 )
2016
6
Preoperative Presentation of a Variant of Cerebellar Mutism Syndrome in a Young Boy With Juvenile Pilocytic Astrocytoma. ( 26145481 )
2015
7
Hodgkin's lymphoma in an adolescent previously treated with surgical resection of third ventricular juvenile pilocytic astrocytoma. ( 26113587 )
2015
8
Peduncular Hallucinosis as First Presentation of Juvenile Pilocytic Astrocytoma. ( 26548431 )
2015
9
Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. ( 24456989 )
2014
10
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. ( 25241615 )
2014
11
An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. ( 23495067 )
2013
12
Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. ( 23227384 )
2012
13
Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. ( 22642312 )
2012
14
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. ( 22681727 )
2012
15
Transformation of juvenile pilocytic astrocytoma to anaplastic pilocytic astrocytoma in patients with neurofibromatosis type I. ( 21572348 )
2011
16
Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. ( 20439802 )
2010
17
Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. ( 20121362 )
2010
18
Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. ( 19951034 )
2009
19
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. ( 19603027 )
2009
20
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. ( 19418058 )
2009
21
Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver-Russell syndrome. ( 18661310 )
2008
22
Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle. ( 18255162 )
2008
23
Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy. ( 16902345 )
2006
24
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. ( 16206208 )
2006
25
Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. ( 15665281 )
2005
26
Juvenile pilocytic astrocytoma of the brainstem in children. ( 16206964 )
2004
27
Juvenile pilocytic astrocytoma presenting with subarachnoid hemorrhage. Case report and review of the literature. ( 15287467 )
2004
28
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. ( 15261239 )
2004
29
Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literature. ( 15070126 )
2004
30
Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. ( 12777080 )
2003
31
Juvenile pilocytic astrocytoma. ( 12880155 )
2003
32
Spontaneous cerebellar hemorrhage due to a juvenile pilocytic astrocytoma: case report and review of the literature. ( 11423772 )
2001
33
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. ( 11384146 )
2001
34
Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient. ( 11037859 )
2000
35
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. ( 10416986 )
1999
36
Multicentric juvenile pilocytic astrocytoma occurring primarily in the trigone of the lateral ventricle. ( 10502010 )
1999
37
Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study. ( 9524106 )
1998
38
Hypothalamic juvenile pilocytic astrocytoma presenting with intracerebral hemorrhage. ( 9872037 )
1998
39
Juvenile pilocytic astrocytoma masquerading as amblyopia. ( 9152078 )
1997
40
Diencephalic syndrome and disseminated juvenile pilocytic astrocytomas of the hypothalamic-optic chiasm region. ( 9210720 )
1997
41
Normal evoked otoacoustic emissions with a profound hearing loss due to a juvenile pilocytic astrocytoma. ( 8841714 )
1996
42
Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. ( 7536455 )
1995
43
Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma. ( 8207524 )
1994
44
Leptomeningeal dissemination of juvenile pilocytic astrocytoma: case report. ( 8165503 )
1994
45
Radiation therapy for juvenile pilocytic astrocytoma of the pituitary stalk. Case report. ( 1607955 )
1992
46
Metastatic juvenile pilocytic astrocytoma. Case report. ( 1941128 )
1991
47
Juvenile pilocytic astrocytoma of the optic nerve diagnosed by fine needle aspiration biopsy. ( 3376707 )
1988
48
Treatment results of juvenile pilocytic astrocytoma. ( 3392563 )
1988
49
Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. ( 4020465 )
1985
50
Juvenile pilocytic astrocytoma of the pineal region: report of a case. ( 7104961 )
1982
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Variations for Juvenile Pilocytic Astrocytoma

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Expression for Juvenile Pilocytic Astrocytoma

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Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.
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Pathways for Juvenile Pilocytic Astrocytoma

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Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.68 CDKN2A FGF2 GFAP INSR MAP2K1 NF1
2
Glioma 37
Show member pathways
 12.52 CDKN2A FGF2 MAP2K1 NF1 TP53
3
MAPK signaling pathway 1 37
12.5 FGF2 INSR MAP2K1 NF1 TP53
4
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.39 DDX3X FGF2 MAP2K1 TP53
5
Neuroscience 4
12.25 ENO2 GFAP MBP NF1 TNC
6
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 11.92 MAP2K1 MBP TIMP3 TP53
7
Spinal Cord Injury 1
11.83 GFAP MBP TP53
8
DNA Damage Response (only ATM dependent) 1
11.78 CDKN2A INSR TP53
9
Neural Crest Differentiation 1
11.72 FGF2 GFAP MBP
10
HIF-1 signaling pathway 37
11.7 ENO2 INSR MAP2K1
11
Proteoglycans in cancer 37
11.66 CD44 FGF2 MAP2K1 TIMP3 TP53
12
Angiogenesis (CST) 4
11.64 FGF2 TIMP3 TNC
13
Glioblastoma Multiforme 64
11.6 CDKN2A MAP2K1 NF1 TP53
14
MicroRNAs in cancer 37
11.58 CD44 CDKN2A MAP2K1 TIMP3 TNC TP53
15
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.57 CD44 FGF2 GFAP
16
Bladder cancer 37 1
11.52 CDKN2A MAP2K1 TP53
17
Senescence and Autophagy in Cancer 1
11.48 CD44 CDKN2A MAP2K1 TP53
18
MECP2 and Associated Rett Syndrome 1
11.37 FGF2 MBP NF1
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GO Terms for Juvenile Pilocytic Astrocytoma

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Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 CDKN2A FGF2 INSR MAP2K1 TP53
2 MAPK cascade GO:0000165 9.71 FGF2 MAP2K1 MBP NF1
3 activation of MAPK activity GO:0000187 9.7 FGF2 INSR MAP2K1
4 negative regulation of cell growth GO:0030308 9.69 CDKN2A DDX3X TP53
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 CD44 FGF2 INSR MAP2K1
6 positive regulation of gene expression GO:0010628 9.65 CDKN2A DDX3X MAP2K1 TNC TP53
7 wound healing GO:0042060 9.61 FGF2 NF1 TNC
8 hyaluronan catabolic process GO:0030214 9.49 CD44 FGF2
9 replicative senescence GO:0090399 9.46 CDKN2A TP53
10 extracellular matrix organization GO:0030198 9.35 CD44 FGF2 GFAP NF1 TNC
11 Bergmann glial cell differentiation GO:0060020 9.32 GFAP MAP2K1
12 neuron recognition GO:0008038 9.16 NTM OPCML
13 Ras protein signal transduction GO:0007265 8.92 CDKN2A FGF2 NF1 TP53

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 CD276 CD44 CDKN2A DDX3X ENO2 FGF2
2 protease binding GO:0002020 9.13 MBP TIMP3 TP53
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Sources for Juvenile Pilocytic Astrocytoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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