MCID: JVN009
MIFTS: 33

Juvenile Pilocytic Astrocytoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Juvenile Pilocytic Astrocytoma

MalaCards integrated aliases for Juvenile Pilocytic Astrocytoma:

Name: Juvenile Pilocytic Astrocytoma 11 53 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:6811
MeSH 43 D001254
NCIt 49 C27081
UMLS 71 C0280783

Summaries for Juvenile Pilocytic Astrocytoma

Disease Ontology: 11 A pilocytic astrocytoma that occurs during adolescence.

MalaCards based summary: Juvenile Pilocytic Astrocytoma is related to glioma susceptibility 1 and brain cancer, and has symptoms including headache An important gene associated with Juvenile Pilocytic Astrocytoma is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor), and among its related pathways/superpathways are Metabolism of proteins and ERK Signaling. Affiliated tissues include spinal cord, brain and pineal.

Related Diseases for Juvenile Pilocytic Astrocytoma

Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Juvenile Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 glioma susceptibility 1 31.3 TP53 IDH1 H3-3A
2 brain cancer 30.5 TP53 NF1 IDH1 H3-3A
3 oligodendroglioma 30.2 TP53 NF1 IDH1
4 neurofibromatosis, type i 30.2 TP53 NF1 KIAA1549 IDH1
5 meningioma, familial 30.2 TP53 NF1 KIAA1549 IDH1
6 pilocytic astrocytoma 30.2 TP53 NF1 KIAA1549 IDH1 H3C6 H3C4
7 glioma 30.0 TP53 TNC NF1 IDH1
8 cerebellar astrocytoma 29.9 NF1 KIAA1549 IDH1 H3-3A
9 glioblastoma 28.7 TP53 TNC NF1 IDH1 H3C4 H3-3B
10 pilomyxoid astrocytoma 27.9 NF1 LUC7L2 KIAA1549 IDH1 H3C6 H3C4
11 anaplastic astrocytoma 27.7 TP53 TNC NF1 KIAA1549 IDH1 H3C6
12 hydrocephalus 10.4
13 neurofibromatosis 10.3
14 spinal cord ependymoma 10.3 LUC7L2 KIAA1549
15 epidural spinal canal neoplasm 10.3 NF1 KIAA1549
16 optic nerve neoplasm 10.3 NF1 KIAA1549
17 chondroma 10.2 NF1 IDH1
18 medulloblastoma 10.2
19 hemorrhage, intracerebral 10.2
20 amblyopia 10.2
21 arteriovenous malformation 10.2
22 diencephalic syndrome 10.2
23 glial tumor 10.2
24 simple partial epilepsy 10.2 KIAA1549 IDH1
25 chordoid glioma 10.2 KIAA1549 IDH1
26 optic nerve astrocytoma 10.2 NF1 IDH1
27 atypical neurofibroma 10.2 TP53 NF1
28 gangliocytoma 10.2 KIAA1549 IDH1
29 myxopapillary ependymoma 10.2 LUC7L2 KIAA1549
30 papillary craniopharyngioma 10.2 KIAA1549 IDH1
31 astroblastoma 10.2 KIAA1549 IDH1
32 rela fusion-positive ependymoma 10.2 KIAA1549 IDH1
33 diamond-blackfan anemia 11 10.2 TP53 NF1
34 adult malignant schwannoma 10.2 TP53 NF1
35 frontal lobe neoplasm 10.2 TP53 IDH1
36 malignant spindle cell melanoma 10.2 TP53 NF1
37 conjunctival cancer 10.2 TP53 NF1
38 gemistocytic astrocytoma 10.2 TP53 IDH1
39 mixed oligodendroglioma-astrocytoma 10.2 TP53 IDH1
40 neurofibrosarcoma 10.1 TP53 NF1
41 peripheral osteosarcoma 10.1 TP53 H3-3B
42 peritoneal mesothelioma 10.1 TP53 LUC7L2
43 paranasal sinus cancer 10.1 TP53 IDH1
44 nodular malignant melanoma 10.1 TP53 NF1
45 cerebrovascular benign neoplasm 10.1 TP53 IDH1
46 peritoneum cancer 10.1 TP53 LUC7L2
47 childhood pilocytic astrocytoma 10.1 RSBN1L NF1 KIAA1549
48 dicer1 syndrome 10.1 TP53 NF1
49 giant cell reparative granuloma 10.1 NF1 H3-3A
50 klatskin's tumor 10.1 TP53 IDH1

Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to Juvenile Pilocytic Astrocytoma

Symptoms & Phenotypes for Juvenile Pilocytic Astrocytoma

UMLS symptoms related to Juvenile Pilocytic Astrocytoma:


headache

Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

Search Clinical Trials, NIH Clinical Center for Juvenile Pilocytic Astrocytoma

Genetic Tests for Juvenile Pilocytic Astrocytoma

Anatomical Context for Juvenile Pilocytic Astrocytoma

Organs/tissues related to Juvenile Pilocytic Astrocytoma:

MalaCards : Spinal Cord, Brain, Pineal, Cerebellum, Pituitary, Endothelial

Publications for Juvenile Pilocytic Astrocytoma

Articles related to Juvenile Pilocytic Astrocytoma:

(show top 50) (show all 141)
# Title Authors PMID Year
1
3D patient-derived tumor models to recapitulate pediatric brain tumors In Vitro. 62
35381525 2022
2
Pediatric Spinal Cord Diseases. 62
34470868 2021
3
A single center experience in the management of progressive juvenile pilocytic astrocytoma. 62
33870664 2021
4
Aggressively recurring cervical intramedullary anaplastic astrocytoma in a pregnant patient. 62
34621581 2021
5
Incidental Findings on Brain Magnetic Resonance Imaging (MRI) in Pediatric Endocrine Patients. 62
33471712 2020
6
Septum Pellucidum Chronic Encapsulated Hematoma With Osseous Metaplasia Mimicking Recurrent Astrocytoma and Shunt-Related Foreign Body Granuloma. 62
32953346 2020
7
INCIDENTAL FINDINGS ON BRAIN MAGNETIC RESONANCE IMAGING (MRI) IN PEDIATRIC ENDOCRINE PATIENTS. 62
32576030 2020
8
Peripheral circulation miRNA expression of pediatric brain tumors and its relation to tumor miRNA expression levels. 62
32384264 2020
9
Novel Use of Subcostal Polyethylene Bands to Manage Tumor-Related Scoliosis Requiring Serial Imaging: A Case Report. 62
32224656 2020
10
Keyhole Retrosigmoid Craniotomy for Resection of Pontine Juvenile Pilocytic Astrocytoma: 2-Dimensional Operative Video. 62
31329970 2020
11
Supracerebellar Approach to Radiation-Induced Giant Capillary Telangiectasia Within Juvenile Pilocytic Astrocytoma of Upper Brainstem. 62
31479784 2019
12
Predictive measures and outcomes of extent of resection in juvenile pilocytic astrocytoma. 62
31466905 2019
13
Twenty-three years follow-up after low-dose Gamma Knife surgery of a brainstem juvenile pilocytic astrocytoma: a case report and review of the literature. 62
30997566 2019
14
Unusual KRAS missense mutation (p.E63K) in patient with juvenile pilocytic astrocytoma of the tectum. 62
30798277 2019
15
Successful Use of Fludrocortisone in a Child with Refractory Cerebral Salt Wasting Syndrome: A Case Report and Review of Literature. 62
30648045 2018
16
Circulating serum oncologic miRNA in pediatric juvenile pilocytic astrocytoma patients predicts mural nodule volume. 62
29911246 2018
17
Regression after subtotal resection of an optic pathway glioma in an adult without adjuvant therapy: case report. 62
29999469 2018
18
Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children. 62
29125440 2018
19
Resection of a Pediatric Thalamic Juvenile Pilocytic Astrocytoma with Whole Brain Tractography. 62
29234572 2017
20
Visual and ocular motor outcomes in children with posterior fossa tumors. 62
28867398 2017
21
Apparent diffusion coefficient in differentiation of pediatric posterior fossa tumors. 62
28550357 2017
22
Chemoradiation impairs normal developmental cortical thinning in medulloblastoma. 62
28534154 2017
23
A Review of Visual and Oculomotor Outcomes in Children With Posterior Fossa Tumors. 62
28941523 2017
24
Proton Therapy for Juvenile Pilocytic Astrocytoma: Quantifying Treatment Responses by Magnetic Resonance Diffusion Tensor Imaging. 62
31772991 2017
25
Spontaneous aneurysmal subarachnoid haemorrhage in a child with multiply recurrent posterior fossa juvenile pilocytic astrocytoma. 62
27927709 2016
26
Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery. 62
27741220 2016
27
Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. 62
27314542 2016
28
Peduncular Hallucinosis as First Presentation of Juvenile Pilocytic Astrocytoma. 62
26548431 2016
29
Hearing Loss in Patients Who Received Cranial Radiation Therapy for Childhood Cancer. 62
26811531 2016
30
Extended Volumetric Follow-up of Juvenile Pilocytic Astrocytomas Treated with Proton Beam Therapy. 62
31772980 2016
31
Preoperative Presentation of a Variant of Cerebellar Mutism Syndrome in a Young Boy With Juvenile Pilocytic Astrocytoma. 62
26145481 2015
32
Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma. 62
26181420 2015
33
Hodgkin's lymphoma in an adolescent previously treated with surgical resection of third ventricular juvenile pilocytic astrocytoma. 62
26113587 2015
34
Involvement of the neural stem cell compartment by pediatric and adult gliomas: a retrospective review of 377 cases. 62
25502962 2015
35
Primary brain tumors and posterior reversible encephalopathy syndrome. 62
26034631 2014
36
Intraoperative magnetic resonance imaging for resection of intra-axial brain lesions: a decade of experience using low-field magnetic resonance imaging, Polestar N-10, 20, 30 systems. 62
24518885 2014
37
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. 62
25241615 2014
38
Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. 62
24456989 2014
39
The lost art of localization: Franc Ingraham's legacy in pediatric neurosurgery. 62
24073750 2013
40
An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. 62
23495067 2013
41
Young Australian adults with NF1 have poor access to health care, high complication rates, and limited disease knowledge. 62
23427176 2013
42
B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma. 62
23232807 2013
43
Tumors of the superior medullary velum in infancy and childhood: report of 6 cases. 62
23121115 2013
44
Outcome of patients with pilocytic astrocytoma and leptomeningeal dissemination. 62
22401918 2012
45
Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. 62
22642312 2012
46
Rosette-forming glioneuronal tumour of the lateral ventricle in a patient with neurofibromatosis 1. 62
22613490 2012
47
Central nervous system (CNS) tumor trends in children in a western Canadian province: a population-based 22-year retrospective study. 62
22109636 2012
48
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. 62
22681727 2012
49
Incidental MRI findings of acute gadolinium hypersensitivity. 62
22649344 2012
50
Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. 62
23227384 2012

Variations for Juvenile Pilocytic Astrocytoma

Expression for Juvenile Pilocytic Astrocytoma

Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

Pathways for Juvenile Pilocytic Astrocytoma

Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 TP53 TNC NTM H3C6 H3C4 H3C3
2
Show member pathways
13.62 TP53 TNC NF1 H3C6 H3C4 H3C3
3 13.57 TP53 NF1 H3C6 H3C4 H3C3 H3-3B
4
Show member pathways
13.52 TP53 NF1 KIAA1549 IDH1 H3C6 H3C4
5
Show member pathways
13.33 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
6
Show member pathways
13.31 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
7
Show member pathways
13.27 TP53 NF1 H3C6 H3C4 H3C3 H3-3B
8
Show member pathways
13.27 H3-3A H3-3B H3C3 H3C4 H3C6 IDH1
9
Show member pathways
13.11 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
10
Show member pathways
12.92 H3C6 H3C4 H3C3 H3-3B H3-3A
11
Show member pathways
12.85 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
12
Show member pathways
12.81 H3-3A H3-3B H3C3 H3C4 H3C6
13
Show member pathways
12.81 H3C6 H3C4 H3C3 H3-3B H3-3A
14
Show member pathways
12.71 H3C6 H3C4 H3C3 H3-3B H3-3A
15
Show member pathways
12.55 H3-3A H3-3B H3C3 H3C4 H3C6 TP53
16
Show member pathways
12.54 H3C6 H3C4 H3C3 H3-3B H3-3A
17
Show member pathways
12.52 H3C6 H3C4 H3C3 H3-3B H3-3A
18
Show member pathways
12.48 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
19
Show member pathways
11.85 H3C6 H3C4 H3C3 H3-3B H3-3A
20 11.51 H3C6 H3C4 H3C3 H3-3B H3-3A
21 11.19 H3C6 H3C4 H3C3
22
Show member pathways
11.16 H3-3B H3-3A
23 11.14 H3-3B H3-3A
24 11.08 H3C6 H3C4 H3-3B H3-3A
25 10.85 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
26 10.67 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A

GO Terms for Juvenile Pilocytic Astrocytoma

Cellular components related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.73 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
2 chromosome GO:0005694 9.55 H3C6 H3C4 H3C3 H3-3B H3-3A
3 nucleosome GO:0000786 9.32 H3C6 H3C4 H3C3 H3-3B H3-3A

Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosome assembly GO:0006334 9.65 H3C6 H3C4 H3C3 H3-3B H3-3A
2 epigenetic regulation of gene expression GO:0040029 9.63 H3C6 H3C4 H3C3
3 negative regulation of neuroblast proliferation GO:0007406 9.56 TP53 NF1
4 glial cell proliferation GO:0014009 9.54 TP53 NF1
5 negative regulation of glial cell proliferation GO:0060253 9.5 TP53 NF1
6 telomere organization GO:0032200 9.32 H3C6 H3C4 H3C3 H3-3B H3-3A

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.73 TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
2 structural constituent of chromatin GO:0030527 9.32 H3C6 H3C4 H3C3 H3-3B H3-3A

Sources for Juvenile Pilocytic Astrocytoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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