Juvenile Pilocytic Astrocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Juvenile Pilocytic Astrocytoma

MalaCards integrated aliases for Juvenile Pilocytic Astrocytoma:

Name: Juvenile Pilocytic Astrocytoma ¹¹ ⁵³ ¹⁴ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:6811

MeSH ⁴³ D001254

NCIt ⁴⁹ C27081

UMLS ⁷¹ C0280783

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Summaries for Juvenile Pilocytic Astrocytoma

Disease Ontology: ¹¹ A pilocytic astrocytoma that occurs during adolescence.

MalaCards based summary: Juvenile Pilocytic Astrocytoma is related to glioma susceptibility 1 and brain cancer, and has symptoms including headache An important gene associated with Juvenile Pilocytic Astrocytoma is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor), and among its related pathways/superpathways are Metabolism of proteins and ERK Signaling. Affiliated tissues include spinal cord, brain and pineal.

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Related Diseases for Juvenile Pilocytic Astrocytoma

Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Juvenile Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)

#	Related Disease	Score	Top Affiliating Genes
1	glioma susceptibility 1	31.3	TP53 IDH1 H3-3A
2	brain cancer	30.5	TP53 NF1 IDH1 H3-3A
3	oligodendroglioma	30.2	TP53 NF1 IDH1
4	neurofibromatosis, type i	30.2	TP53 NF1 KIAA1549 IDH1
5	meningioma, familial	30.2	TP53 NF1 KIAA1549 IDH1
6	pilocytic astrocytoma	30.2	TP53 NF1 KIAA1549 IDH1 H3C6 H3C4
7	glioma	30.0	TP53 TNC NF1 IDH1
8	cerebellar astrocytoma	29.9	NF1 KIAA1549 IDH1 H3-3A
9	glioblastoma	28.7	TP53 TNC NF1 IDH1 H3C4 H3-3B
10	pilomyxoid astrocytoma	27.9	NF1 LUC7L2 KIAA1549 IDH1 H3C6 H3C4
11	anaplastic astrocytoma	27.7	TP53 TNC NF1 KIAA1549 IDH1 H3C6
12	hydrocephalus	10.4
13	neurofibromatosis	10.3
14	spinal cord ependymoma	10.3	LUC7L2 KIAA1549
15	epidural spinal canal neoplasm	10.3	NF1 KIAA1549
16	optic nerve neoplasm	10.3	NF1 KIAA1549
17	chondroma	10.2	NF1 IDH1
18	medulloblastoma	10.2
19	hemorrhage, intracerebral	10.2
20	amblyopia	10.2
21	arteriovenous malformation	10.2
22	diencephalic syndrome	10.2
23	glial tumor	10.2
24	simple partial epilepsy	10.2	KIAA1549 IDH1
25	chordoid glioma	10.2	KIAA1549 IDH1
26	optic nerve astrocytoma	10.2	NF1 IDH1
27	atypical neurofibroma	10.2	TP53 NF1
28	gangliocytoma	10.2	KIAA1549 IDH1
29	myxopapillary ependymoma	10.2	LUC7L2 KIAA1549
30	papillary craniopharyngioma	10.2	KIAA1549 IDH1
31	astroblastoma	10.2	KIAA1549 IDH1
32	rela fusion-positive ependymoma	10.2	KIAA1549 IDH1
33	diamond-blackfan anemia 11	10.2	TP53 NF1
34	adult malignant schwannoma	10.2	TP53 NF1
35	frontal lobe neoplasm	10.2	TP53 IDH1
36	malignant spindle cell melanoma	10.2	TP53 NF1
37	conjunctival cancer	10.2	TP53 NF1
38	gemistocytic astrocytoma	10.2	TP53 IDH1
39	mixed oligodendroglioma-astrocytoma	10.2	TP53 IDH1
40	neurofibrosarcoma	10.1	TP53 NF1
41	peripheral osteosarcoma	10.1	TP53 H3-3B
42	peritoneal mesothelioma	10.1	TP53 LUC7L2
43	paranasal sinus cancer	10.1	TP53 IDH1
44	nodular malignant melanoma	10.1	TP53 NF1
45	cerebrovascular benign neoplasm	10.1	TP53 IDH1
46	peritoneum cancer	10.1	TP53 LUC7L2
47	childhood pilocytic astrocytoma	10.1	RSBN1L NF1 KIAA1549
48	dicer1 syndrome	10.1	TP53 NF1
49	giant cell reparative granuloma	10.1	NF1 H3-3A
50	klatskin's tumor	10.1	TP53 IDH1

Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:

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Symptoms & Phenotypes for Juvenile Pilocytic Astrocytoma

UMLS symptoms related to Juvenile Pilocytic Astrocytoma:

headache

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Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

Search Clinical Trials, NIH Clinical Center for Juvenile Pilocytic Astrocytoma

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Genetic Tests for Juvenile Pilocytic Astrocytoma

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Anatomical Context for Juvenile Pilocytic Astrocytoma

Organs/tissues related to Juvenile Pilocytic Astrocytoma:

MalaCards : Spinal Cord, Brain, Pineal, Cerebellum, Pituitary, Endothelial

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Publications for Juvenile Pilocytic Astrocytoma

Articles related to Juvenile Pilocytic Astrocytoma:

(show top 50) (show all 141)

#	Title	Authors	PMID	Year
1	3D patient-derived tumor models to recapitulate pediatric brain tumors In Vitro. ⁶²	Tang-Schomer MD...George J	35381525	2022
2	Pediatric Spinal Cord Diseases. ⁶²	Lu VM...Niazi TN	34470868	2021
3	A single center experience in the management of progressive juvenile pilocytic astrocytoma. ⁶²	Shams I...Fleming AJ	33870664	2021
4	Aggressively recurring cervical intramedullary anaplastic astrocytoma in a pregnant patient. ⁶²	Caruso JP...Bagley CA	34621581	2021
5	Incidental Findings on Brain Magnetic Resonance Imaging (MRI) in Pediatric Endocrine Patients. ⁶²	Brener A...Lebenthal Y	33471712	2020
6	Septum Pellucidum Chronic Encapsulated Hematoma With Osseous Metaplasia Mimicking Recurrent Astrocytoma and Shunt-Related Foreign Body Granuloma. ⁶²	Roberti F...Bell J	32953346	2020
7	INCIDENTAL FINDINGS ON BRAIN MAGNETIC RESONANCE IMAGING (MRI) IN PEDIATRIC ENDOCRINE PATIENTS. ⁶²	Brener A...Lebenthal Y	32576030	2020
8	Peripheral circulation miRNA expression of pediatric brain tumors and its relation to tumor miRNA expression levels. ⁶²	Bookland M...Kolmakova A	32384264	2020
9	Novel Use of Subcostal Polyethylene Bands to Manage Tumor-Related Scoliosis Requiring Serial Imaging: A Case Report. ⁶²	Toll BJ...Hwang SW	32224656	2020
10	Keyhole Retrosigmoid Craniotomy for Resection of Pontine Juvenile Pilocytic Astrocytoma: 2-Dimensional Operative Video. ⁶²	Yagmurlu K...Syed H	31329970	2020
11	Supracerebellar Approach to Radiation-Induced Giant Capillary Telangiectasia Within Juvenile Pilocytic Astrocytoma of Upper Brainstem. ⁶²	Rubio RR...Abla AA	31479784	2019
12	Predictive measures and outcomes of extent of resection in juvenile pilocytic astrocytoma. ⁶²	Maharaj A...Yarascavitch B	31466905	2019
13	Twenty-three years follow-up after low-dose Gamma Knife surgery of a brainstem juvenile pilocytic astrocytoma: a case report and review of the literature. ⁶²	Liu JS...Karlsson B	30997566	2019
14	Unusual KRAS missense mutation (p.E63K) in patient with juvenile pilocytic astrocytoma of the tectum. ⁶²	Chau LQ...Crawford JR	30798277	2019
15	Successful Use of Fludrocortisone in a Child with Refractory Cerebral Salt Wasting Syndrome: A Case Report and Review of Literature. ⁶²	Gurnurkar S...Chegondi M	30648045	2018
16	Circulating serum oncologic miRNA in pediatric juvenile pilocytic astrocytoma patients predicts mural nodule volume. ⁶²	Bookland M...Kolmakova A	29911246	2018
17	Regression after subtotal resection of an optic pathway glioma in an adult without adjuvant therapy: case report. ⁶²	Hidalgo ET...Wisoff JH	29999469	2018
18	Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children. ⁶²	Yecies D...Grant G	29125440	2018
19	Resection of a Pediatric Thalamic Juvenile Pilocytic Astrocytoma with Whole Brain Tractography. ⁶²	Weiner HL...Placantonakis DG	29234572	2017
20	Visual and ocular motor outcomes in children with posterior fossa tumors. ⁶²	Peeler CE...Heidary G	28867398	2017
21	Apparent diffusion coefficient in differentiation of pediatric posterior fossa tumors. ⁶²	Zitouni S...Kontas O	28550357	2017
22	Chemoradiation impairs normal developmental cortical thinning in medulloblastoma. ⁶²	Kundu P...Gibbs IC	28534154	2017
23	A Review of Visual and Oculomotor Outcomes in Children With Posterior Fossa Tumors. ⁶²	Peeler CE	28941523	2017
24	Proton Therapy for Juvenile Pilocytic Astrocytoma: Quantifying Treatment Responses by Magnetic Resonance Diffusion Tensor Imaging. ⁶²	Hou P...Grosshans DR	31772991	2017
25	Spontaneous aneurysmal subarachnoid haemorrhage in a child with multiply recurrent posterior fossa juvenile pilocytic astrocytoma. ⁶²	Chen DY...Crawford JR	27927709	2016
26	Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery. ⁶²	Lee JY...Singhal S	27741220	2016
27	Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. ⁶²	Pricola Fehnel K...Smith ER	27314542	2016
28	Peduncular Hallucinosis as First Presentation of Juvenile Pilocytic Astrocytoma. ⁶²	Biswas SN...Chakraborty PP	26548431	2016
29	Hearing Loss in Patients Who Received Cranial Radiation Therapy for Childhood Cancer. ⁶²	Bass JK...Merchant TE	26811531	2016
30	Extended Volumetric Follow-up of Juvenile Pilocytic Astrocytomas Treated with Proton Beam Therapy. ⁶²	Mannina EM...McMullen KP	31772980	2016
31	Preoperative Presentation of a Variant of Cerebellar Mutism Syndrome in a Young Boy With Juvenile Pilocytic Astrocytoma. ⁶²	Chen DY...Crawford JR	26145481	2015
32	Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma. ⁶²	Davis J...Hummel TR	26181420	2015
33	Hodgkin's lymphoma in an adolescent previously treated with surgical resection of third ventricular juvenile pilocytic astrocytoma. ⁶²	Chen DY...Crawford JR	26113587	2015
34	Involvement of the neural stem cell compartment by pediatric and adult gliomas: a retrospective review of 377 cases. ⁶²	Marsh JC...Fangusaro J	25502962	2015
35	Primary brain tumors and posterior reversible encephalopathy syndrome. ⁶²	Kamiya-Matsuoka C...Gilbert MR	26034631	2014
36	Intraoperative magnetic resonance imaging for resection of intra-axial brain lesions: a decade of experience using low-field magnetic resonance imaging, Polestar N-10, 20, 30 systems. ⁶²	Livne O...Cohen ZR	24518885	2014
37	A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. ⁶²	Catli G...Mutafoglu K	25241615	2014
38	Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. ⁶²	Ginat DT...Nahed B	24456989	2014
39	The lost art of localization: Franc Ingraham's legacy in pediatric neurosurgery. ⁶²	Cohen AR...Lidov HG	24073750	2013
40	An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. ⁶²	Minhas HM...Morrow EM	23495067	2013
41	Young Australian adults with NF1 have poor access to health care, high complication rates, and limited disease knowledge. ⁶²	Oates EC...North KN	23427176	2013
42	B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma. ⁶²	Zhou Z...Souweidane MM	23232807	2013
43	Tumors of the superior medullary velum in infancy and childhood: report of 6 cases. ⁶²	Tomita T...Frassanito P	23121115	2013
44	Outcome of patients with pilocytic astrocytoma and leptomeningeal dissemination. ⁶²	Mazloom A...Paulino AC	22401918	2012
45	Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. ⁶²	Nachman AJ	22642312	2012
46	Rosette-forming glioneuronal tumour of the lateral ventricle in a patient with neurofibromatosis 1. ⁶²	Kemp S...Dexter MA	22613490	2012
47	Central nervous system (CNS) tumor trends in children in a western Canadian province: a population-based 22-year retrospective study. ⁶²	Rosychuk RJ...Stobart K	22109636	2012
48	Juvenile pilocytic astrocytoma in association with arteriovenous malformation. ⁶²	Soltanolkotabi M...Shaibani A	22681727	2012
49	Incidental MRI findings of acute gadolinium hypersensitivity. ⁶²	Amene C...Crawford JR	22649344	2012
50	Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. ⁶²	Amene CS...Crawford JR	23227384	2012

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Genes for Juvenile Pilocytic Astrocytoma

Genes related to Juvenile Pilocytic Astrocytoma (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	LUC7L2	LUC7 Like 2, Pre-MRNA Splicing Factor	Protein Coding	6.68	DISEASES inferred ¹⁴ ¹⁴
2	KIAA1549	KIAA1549	Protein Coding	6.52	DISEASES inferred ¹⁴
3	TNC	Tenascin C	Protein Coding	6.48	Novoseek inferred ⁵³	7531617
4	NF1	Neurofibromin 1	Protein Coding	6.23	DISEASES inferred ¹⁴
5	TMEM158	Transmembrane Protein 158	Protein Coding	4.78	DISEASES inferred ¹⁴
6	RSBN1L	Round Spermatid Basic Protein 1 Like	Protein Coding	4.75	DISEASES inferred ¹⁴
7	TP53	Tumor Protein P53	Protein Coding	4.7	DISEASES inferred ¹⁴
8	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	4.7	DISEASES inferred ¹⁴
9	H3-3B	H3.3 Histone B	Protein Coding	4.61	DISEASES inferred ¹⁴
10	H3-3A	H3.3 Histone A	Protein Coding	4.6	DISEASES inferred ¹⁴
11	H3C6	H3 Clustered Histone 6	Protein Coding	4.55	DISEASES inferred ¹⁴
12	H3C3	H3 Clustered Histone 3	Protein Coding	4.55	DISEASES inferred ¹⁴
13	H3C4	H3 Clustered Histone 4	Protein Coding	4.54	DISEASES inferred ¹⁴
14	NTM	Neurotrimin	Protein Coding	4.51	DISEASES inferred ¹⁴

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Variations for Juvenile Pilocytic Astrocytoma

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Expression for Juvenile Pilocytic Astrocytoma

Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

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Pathways for Juvenile Pilocytic Astrocytoma

Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁶ Show member pathways Post-translational protein modification ⁶⁶	13.73	TP53 TNC NTM H3C6 H3C4 H3C3
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.62	TP53 TNC NF1 H3C6 H3C4 H3C3
3	Signal Transduction ⁶⁶	13.57	TP53 NF1 H3C6 H3C4 H3C3 H3-3B
4	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.52	TP53 NF1 KIAA1549 IDH1 H3C6 H3C4
5	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.33	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
6	Cell Cycle, Mitotic ⁶⁶ Show member pathways Cell Cycle ⁶⁶ M Phase ⁶⁶	13.31	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
7	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.27	TP53 NF1 H3C6 H3C4 H3C3 H3-3B
8	Cellular responses to stimuli ⁶⁶ Show member pathways Cellular responses to stress ⁶⁶	13.27	H3-3A H3-3B H3C3 H3C4 H3C6 IDH1
9	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.11	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
10	Assembly of the pre-replicative complex ⁶⁶ Show member pathways DNA Replication ⁶⁶ DNA Replication Pre-Initiation ⁶⁶ RUNX1 regulates transcription of genes involved in differentiation of HSCs ⁶⁶ Transcriptional regulation by RUNX1 ⁶⁶	12.92	H3C6 H3C4 H3C3 H3-3B H3-3A
11	Golgi-to-ER retrograde transport ⁶⁶ Show member pathways COPI-dependent Golgi-to-ER retrograde traffic ⁶⁶ Factors involved in megakaryocyte development and platelet production ⁶⁶ Intra-Golgi and retrograde Golgi-to-ER traffic ⁶⁶ Kinesins ⁶⁶ MHC class II antigen presentation ⁶⁶	12.85	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
12	RNA Polymerase II Transcription Initiation And Promoter Clearance ⁶⁶ Show member pathways Assembly of RNA Polymerase-II Initiation Complex ⁶⁴ Crosstalk Between CARM1 and ESRs ⁶⁴ Eukaryotic transcription initiation ⁷⁴ HIV Transcription Initiation ⁶⁶ Protein Acetylation and Deacetylation ⁶⁴ RNA Polymerase II HIV Promoter Escape ⁶⁶ RNA Polymerase II Promoter Escape ⁶⁶ RNA Polymerase II Transcription Initiation ⁶⁶ RNA Polymerase II Transcription Pre-Initiation And Promoter Opening ⁶⁶ Transcription Ligand-Dependent Transcription of Retinoid-Target genes ²² Transcription of mRNA ⁶⁴	12.81	H3-3A H3-3B H3C3 H3C4 H3C6
13	ESR-mediated signaling ⁶⁶ Show member pathways Estrogen-dependent gene expression ⁶⁶ RUNX1 regulates estrogen receptor mediated transcription ⁶⁶ Signaling by Nuclear Receptors ⁶⁶	12.81	H3C6 H3C4 H3C3 H3-3B H3-3A
14	Signaling by WNT ⁶⁶ Show member pathways TCF dependent signaling in response to WNT ⁶⁶	12.71	H3C6 H3C4 H3C3 H3-3B H3-3A
15	Pre-NOTCH Expression and Processing ⁶⁶ Show member pathways Defective LFNG causes SCDO3 ⁶⁶ Pre-NOTCH Processing in Golgi ⁶⁶ Pre-NOTCH Processing in the Endoplasmic Reticulum ⁶⁶ Pre-NOTCH Transcription and Translation ⁶⁶ Signaling by NOTCH ⁶⁶	12.55	H3-3A H3-3B H3C3 H3C4 H3C6 TP53
16	Meiosis ⁶⁶ Show member pathways Meiotic recombination ⁶⁶ Meiotic synapsis ⁶⁶ Reproduction ⁶⁶	12.54	H3C6 H3C4 H3C3 H3-3B H3-3A
17	Gene Silencing by RNA ⁶⁶ Show member pathways Golgi Cisternae Pericentriolar Stack Reorganization ⁶⁶ MASTL Facilitates Mitotic Progression ⁶⁶ Mitotic Prophase ⁶⁶ RNAi Pathway ⁶⁴ Small interfering RNA (siRNA) biogenesis ⁶⁶ Transcriptional regulation by small RNAs ⁶⁶ tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ⁶⁶	12.52	H3C6 H3C4 H3C3 H3-3B H3-3A
18	Cellular Senescence ⁶⁶ Show member pathways Oxidative Stress Induced Senescence ⁶⁶ Senescence-Associated Secretory Phenotype (SASP) ⁶⁶	12.48	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
19	PKMTs methylate histone lysines ⁶⁶ Show member pathways Histone modifications ⁷⁴	11.85	H3C6 H3C4 H3C3 H3-3B H3-3A
20	Interferon Pathway ⁶⁴	11.51	H3C6 H3C4 H3C3 H3-3B H3-3A
21	Interleukin-7 signaling ⁶⁶	11.19	H3C6 H3C4 H3C3
22	Tumor suppressor activity of SMARCB1 ⁷⁴ Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁶	11.16	H3-3B H3-3A
23	Cell cycle_Chromosome condensation in prometaphase ²²	11.14	H3-3B H3-3A
24	FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma ⁷⁴	11.08	H3C6 H3C4 H3-3B H3-3A
25	Transcription_Transcription factor Tubby signaling pathways ²²	10.85	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
26	Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome ⁷⁴	10.67	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A

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GO Terms for Juvenile Pilocytic Astrocytoma

Cellular components related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex	GO:0032991	9.73	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
2	chromosome	GO:0005694	9.55	H3C6 H3C4 H3C3 H3-3B H3-3A
3	nucleosome	GO:0000786	9.32	H3C6 H3C4 H3C3 H3-3B H3-3A

Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleosome assembly	GO:0006334	9.65	H3C6 H3C4 H3C3 H3-3B H3-3A
2	epigenetic regulation of gene expression	GO:0040029	9.63	H3C6 H3C4 H3C3
3	negative regulation of neuroblast proliferation	GO:0007406	9.56	TP53 NF1
4	glial cell proliferation	GO:0014009	9.54	TP53 NF1
5	negative regulation of glial cell proliferation	GO:0060253	9.5	TP53 NF1
6	telomere organization	GO:0032200	9.32	H3C6 H3C4 H3C3 H3-3B H3-3A

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein heterodimerization activity	GO:0046982	9.73	TP53 H3C6 H3C4 H3C3 H3-3B H3-3A
2	structural constituent of chromatin	GO:0030527	9.32	H3C6 H3C4 H3C3 H3-3B H3-3A

Sources

Sources for Juvenile Pilocytic Astrocytoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: JVN009 MIFTS: 33	Juvenile Pilocytic Astrocytoma Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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