MCID: JVN009
MIFTS: 55

Juvenile Pilocytic Astrocytoma

Categories: Bone diseases, Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Juvenile Pilocytic Astrocytoma

MalaCards integrated aliases for Juvenile Pilocytic Astrocytoma:

Name: Juvenile Pilocytic Astrocytoma 12 52 54 15 71
Pilocytic Astrocytoma 52 58 29 54 6

Characteristics:

Orphanet epidemiological data:

58
pilocytic astrocytoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6811
MeSH 43 D001254
NCIt 49 C27081
ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 72 C0334583
Orphanet 58 ORPHA251612
UMLS 71 C0280783

Summaries for Juvenile Pilocytic Astrocytoma

NIH Rare Diseases : 52 Pilocytic astrocytoma is an often benign , slow-growing tumor of the brain or spinal cord. The tumor may be in the form of a cyst and usually does not spread to nearby tissues . Symptoms vary depending upon the size and location of the tumor. Most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. The underlying cause of a pilocytic astrocytoma is unknown. It most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome , and tuberous sclerosis . This type of tumor can often be cured with surgery.

MalaCards based summary : Juvenile Pilocytic Astrocytoma, also known as pilocytic astrocytoma, is related to childhood pilocytic astrocytoma and glial tumor, and has symptoms including headache An important gene associated with Juvenile Pilocytic Astrocytoma is NF1 (Neurofibromin 1), and among its related pathways/superpathways are ERK Signaling and Phospholipase-C Pathway. The drugs Donepezil and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related phenotypes are Decreased sensitivity to paclitaxel and homeostasis/metabolism

Wikipedia : 74 A pilocytic astrocytoma (and its variant juvenile pilomyxoid astrocytoma) is a brain tumor that occurs... more...

Related Diseases for Juvenile Pilocytic Astrocytoma

Diseases related to Juvenile Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 childhood pilocytic astrocytoma 34.6 NF1 LUC7L2 IDH1
2 glial tumor 31.1 PTEN OLIG2 IDH1
3 obstructive hydrocephalus 31.1 SYP OLIG2 NF1 GFAP
4 neurofibromatosis, type iv, of riccardi 31.0 SDHA PTEN NF1 KRAS
5 anaplastic oligodendroglioma 31.0 OLIG2 MGMT
6 arteriovenous malformation 30.9 TIMP3 PTEN KRAS
7 malignant glioma 30.7 PTEN MGMT GFAP FGF2 CDK4
8 high-grade astrocytoma 30.6 PTEN IDH1
9 hydromyelia 30.6 S100B PTEN
10 cerebellar astrocytoma 30.6 NF1 IDH1
11 benign ependymoma 30.5 SYP S100B NF1 NES MGMT GFAP
12 gliofibroma 30.5 SYP NF1 IDH1 GFAP
13 fibrillary astrocytoma 30.5 PTEN OLIG2 NF1 MGMT LUC7L2 IDH1
14 hemangioblastoma 30.5 SYP S100B PDGFRB GFAP
15 optic nerve glioma 30.5 S100B NF1 NES GFAP
16 rosette-forming glioneuronal tumor 30.5 SYP S100B
17 pleomorphic xanthoastrocytoma 30.5 SYP S100B MGMT IDH1 GFAP
18 cystic teratoma 30.4 SYP PTEN KRAS GFAP
19 papilloma of choroid plexus 30.4 SYP S100B GFAP
20 brain glioma 30.4 NES MGMT IDH1 GFAP
21 atypical teratoid rhabdoid tumor 30.3 SYP S100B GFAP
22 anaplastic ependymoma 30.2 SYP S100B PTEN GFAP
23 subependymal giant cell astrocytoma 30.2 SYP S100B NES GFAP
24 myxopapillary ependymoma 30.1 SYP S100B LUC7L2 GFAP
25 pilomyxoid astrocytoma 30.1 SYP NF1 LUC7L2 KRAS IDH1 GFAP
26 hydrocephalus 30.1 SYP S100B PTEN PDGFRB NES GFAP
27 ganglioglioma 30.0 SYP S100B NF1 NES LUC7L2 GFAP
28 adenocarcinoma 30.0 TIMP3 PTEN PDGFRB KRAS CDK4
29 gemistocytic astrocytoma 30.0 S100B PTEN MGMT IDH1 GFAP
30 glioma susceptibility 1 30.0 TNC PTEN OLIG2 NES MGMT IDH1
31 supratentorial primitive neuroectodermal tumor 29.9 SYP S100B LUC7L2 IDH1 GFAP
32 meningioma, familial 29.9 SYP PTEN OLIG2 NF1 MGMT IDH1
33 glioma 29.9 TNC PTEN PDGFRB NF1 IDH1 FGF2
34 dysembryoplastic neuroepithelial tumor 29.9 SYP S100B OLIG2 NES LUC7L2 IDH1
35 neurilemmoma 29.7 SOX10 S100B PDGFRB NF1 NES GFAP
36 neuroblastoma 29.2 SYP PTEN PDGFRB NF1 NES GFAP
37 grade iii astrocytoma 29.2 PTEN PDGFRB OLIG2 NES MGMT IDH1
38 brain cancer 28.7 SYP PTEN PDGFRB OLIG2 NF1 NES
39 glioblastoma multiforme 28.6 TIMP3 SYP PTEN PDGFRB PDGFA NF1
40 oligodendroglioma 28.5 SYP SOX10 S100B PTEN PDGFA OLIG2
41 medulloblastoma 28.2 TIMP3 SYP S100B PTEN PDGFRB PDGFA
42 gliosarcoma 28.1 SYP S100B PTEN PDGFRB OLIG2 NF1
43 pilocytic astrocytoma of cerebellum 12.7
44 astrocytoma 11.0
45 urachal adenocarcinoma 10.6 NF1 KRAS
46 third ventricle chordoid glioma 10.6 OLIG2 GFAP
47 cellular neurofibroma 10.6 SOX10 NF1
48 oligoastrocytoma 10.5 MGMT GFAP
49 desmoplastic infantile ganglioglioma 10.5 SYP GFAP
50 ovarian clear cell adenofibroma 10.5 PTEN KRAS

Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to Juvenile Pilocytic Astrocytoma

Symptoms & Phenotypes for Juvenile Pilocytic Astrocytoma

UMLS symptoms related to Juvenile Pilocytic Astrocytoma:


headache

GenomeRNAi Phenotypes related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 NF1 PTEN

MGI Mouse Phenotypes related to Juvenile Pilocytic Astrocytoma:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 APOD CDK4 FGF2 GFAP IDH1 KRAS
2 behavior/neurological MP:0005386 10.39 APOD CDK4 FGF2 GFAP KRAS NF1
3 mortality/aging MP:0010768 10.33 APOD CDK4 FGF2 GFAP IDH1 KRAS
4 growth/size/body region MP:0005378 10.29 CDK4 GFAP IDH1 KRAS NF1 OLIG2
5 cardiovascular system MP:0005385 10.24 APOD CDK4 FGF2 GFAP KRAS NF1
6 nervous system MP:0003631 10.21 APOD CDK4 FGF2 GFAP KRAS MGMT
7 digestive/alimentary MP:0005381 10.13 CDK4 GFAP KRAS NF1 PDGFA PDGFRB
8 integument MP:0010771 10.13 CDK4 KRAS NF1 PDGFA PDGFRB PTEN
9 muscle MP:0005369 10.13 CDK4 FGF2 GFAP KRAS NF1 OLIG2
10 normal MP:0002873 10.02 CDK4 GFAP KRAS NF1 PDGFRB PTEN
11 neoplasm MP:0002006 10.01 CDK4 FGF2 KRAS MGMT NF1 OLIG2
12 respiratory system MP:0005388 9.81 IDH1 KRAS MGMT NF1 OLIG2 PDGFA
13 pigmentation MP:0001186 9.73 CDK4 KRAS NF1 PTEN SOX10 TIMP3
14 skeleton MP:0005390 9.65 CDK4 FGF2 IDH1 KRAS NF1 OLIG2
15 vision/eye MP:0005391 9.28 CDK4 FGF2 GFAP KRAS NF1 OLIG2

Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

Drugs for Juvenile Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 153)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Lomustine Approved, Investigational Phase 2, Phase 3 13010-47-4 3950
3
Procarbazine Approved, Investigational Phase 2, Phase 3 671-16-9 4915
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
5
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
6
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
7
Histamine Approved, Investigational Phase 3 51-45-6 774
8
Cyproheptadine Approved Phase 3 129-03-3 2913
9 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
10 Nootropic Agents Phase 3
11 Cholinergic Agents Phase 3
12 Cholinesterase Inhibitors Phase 3
13 Liver Extracts Phase 3
14 Cola Phase 3
15 Narcotics Phase 3
16 Anesthetics Phase 3
17 Anesthetics, General Phase 3
18 Analgesics, Opioid Phase 3
19 Adjuvants, Anesthesia Phase 3
20 Central Nervous System Depressants Phase 3
21 Anesthetics, Intravenous Phase 3
22 Analgesics Phase 3
23 Dermatologic Agents Phase 3
24 Neurotransmitter Agents Phase 3
25 Dopamine Uptake Inhibitors Phase 3
26 Central Nervous System Stimulants Phase 3
27 Dexmethylphenidate Hydrochloride Phase 3
28 Dopamine Agents Phase 3
29 Gastrointestinal Agents Phase 3
30 Antipruritics Phase 3
31 Histamine H1 Antagonists Phase 3
32 Serotonin Agents Phase 3
33 Histamine Antagonists Phase 3
34
Histamine Phosphate Phase 3 51-74-1 65513
35 Serotonin Antagonists Phase 3
36 Anti-Allergic Agents Phase 3
37
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
38
Tamoxifen Approved Phase 2 10540-29-1 2733526
39
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
40
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
41
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
42
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
43
Modafinil Approved, Investigational Phase 2 68693-11-8 4236
44
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
45
Sodium citrate Approved, Investigational Phase 1, Phase 2 68-04-2
46
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
47
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
48
Vincristine Approved, Investigational Phase 1, Phase 2 2068-78-2, 57-22-7 5978
49
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
50
Piperazine Approved, Vet_approved Phase 1, Phase 2 110-85-0 4837

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 A Phase II Study of Observation in Favorable Low-Grade Glioma and a Phase II Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma Completed NCT00003375 Phase 2, Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
2 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 A Phase III, Double-Blind, Prospective Randomized Clinical Trial of the Effect of D-threo-methylphenidate HCl (d-MPH) on Quality of Life in Brain Tumor Patients Receiving Radiation Therapy Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
5 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
6 Phase II Treatment of Adults and Children With Progressive Low Grade Gliomas With Temodal Completed NCT00003466 Phase 2 temozolomide
7 A Phase II Trial of Continuous Low-Dose Temozolomide for Patients With Recurrent Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
8 Open Label Phase II Study On STI571 (Glivec) Administered As A Daily Oral Treatment In Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
9 Phase II Treatment of Adults With Recurrent Supratentorial Low Grade Glioma With Gliadel Wafers Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
10 A Phase II Study of Temozolomide (TEMODAR) in the Treatment of Adult Patients With Supratentorial Low Grade Glioma Completed NCT00313729 Phase 2 temozolomide
11 Improved Characterization of Brain Tumors By MRI and MRS Completed NCT00274755 Phase 2 chemotherapy
12 PHASE I STUDY OF ANTI-TENASCIN MONOCLONAL ANTIBODY 131I 81C6 VIA SURGICALLY CREATED CYSTIC RESECTION CAVITY IN THE TREATMENT OF PATIENTS WITH PRIMARY OR METASTATIC MALIGNANT BRAIN TUMORS Completed NCT00002752 Phase 1, Phase 2
13 A Pilot Study of Tamoxifen, Carboplatin and Topotecan in the Treatment of Recurrent or Refractory Primary Brain or Spinal Cord Tumors or Metastatic Epithelial Cancers With Central Nervous System Metastases Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
14 Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases Completed NCT00070161 Phase 2 donepezil hydrochloride
15 ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs Completed NCT00025675 Phase 2 gefitinib
16 Phase I Study of At-Labeled Anti-Tenascin Human/Mouse Chimeric Monoclonal Antibody 81C6 (ch81C6) Via Surgically Created Cystic Resection Cavity in the Treatment of Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
17 Cisplatin, Doxorubicin and Tamoxifen in the Treatment of Incurable Soft Tissue and Endocrine Malignancies Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
18 A Feasibility Study of Armodafinil for Brain Radiation-Induced Fatigue Completed NCT01032200 Phase 2 Armodafinil
19 Phase I/II Trial of STI571 (NSC 716051) in Patients With Recurrent Malignant Gliomas Completed NCT00010049 Phase 1, Phase 2 imatinib mesylate
20 Randomized Trial Assessing the Significance of Bevacizumab in Recurrent Grade II and Grade III Gliomas - The TAVAREC Trial Completed NCT01164189 Phase 2 Temozolomide
21 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
22 Phase I/II Evaluation of Everolimus (RAD001), Radiation and Temozolomide (TMZ) Followed by Adjuvant Temozolomide and Everolimus in Newly Diagnosed Glioblastoma Active, not recruiting NCT00553150 Phase 1, Phase 2 everolimus;temozolomide
23 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
24 A Phase II Study of Photodynamic Therapy (PDT) With Photofrin® (IND 104,613) For Recurrent High Grade Gliomas in Adults Terminated NCT01966809 Phase 2 Photofrin photodynamic therapy.
25 Defining Functional Tissue in Brain Tumors With Integrated Neuroimaging (Pilot Study) Withdrawn NCT00005083 Phase 2
26 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
27 Phase I Study Of SCH66336 (Lonafarnib), A Farnesyl Protein Transferase Inhibitor In Combination With Temozolomide In Gliomas Unknown status NCT00083096 Phase 1 lonafarnib;temozolomide
28 Determination of the In-Tumor-Concentration of Imatinib Mesylate in Malignant Glioma After Oral Administration Completed NCT00401024 Phase 1 imatinib mesylate
29 Phase I Study of Anti-Tenascin Monoclonal Antibody I-Labeled 81C6 Via Surgically Created Cystic Resection Cavity in the Treatment of Patients With Primary Brain Tumors After External Beam Radiotherapy Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
30 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
31 A Phase I/II, Dual-Center, Open-Label Trial of the Safety and Efficacy of Tarceva™ (Erlotinib Hydrochloride) Plus Sirolimus in Patients With Recurrent Malignant Glioma Not on P450-Inducing Anti-Epileptics Completed NCT00509431 Phase 1 Erlotinib + Sirolimus
32 Phase I Evaluation of Sodium Stibogluconate in Combination With Interferon α-2b Followed by Cisplatin, Vinblastine and Dacarbazine for Patients With Melanoma or Malignancies Potentially Responsive to SSG and/or Interferons Completed NCT00498979 Phase 1 cisplatin;sodium stibogluconate;dacarbazine;vinblastine
33 A Phase I Study of Bortezomib and Temozolomide in Patients With Refractory Solid Tumors Completed NCT00544284 Phase 1 bortezomib;temozolomide
34 Photodynamic Therapy (PDT) for Poor Prognosis Recurrent/Refractory Malignant Brain Tumors - A Phase I Study Completed NCT01682746 Phase 1 Photofrin (porfimer sodium) & photodynamic therapy.
35 Pilot Feasibility and Safety Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Genetically-Modified Autologous CD8+ T Cell Clones Completed NCT00730613 Phase 1
36 Phase I Pharmacology Study Of Oral And Intravenous BCX-1777 In Patients With Refractory T-Cell And Non-T-Cell Malignancies Completed NCT00073944 Phase 1 forodesine hydrochloride
37 A Phase I Trial of Subcutaneous And/Or Oral Calcitriol [(1,25-COH)2D3] and Carboplatin in Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
38 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium
39 A PHASE I STUDY OF THE COMBINATION OF CAI AND PACLITAXEL IN ADULT PATIENTS WITH REFRACTORY CANCERS OR LYMPHOMA Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
40 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
41 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
42 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
43 Cognitive Biomarkers in Pediatric Brain Tumor Patients Recruiting NCT02914067 Phase 1
44 Mutant MGMT Gene Transfer Into Human Hematopoietic Progenitors to Protect Hematopoiesis During O6-Benzylguanine (BG, NSC 637037) and Carmustine Followed by Temozolomide Therapy of Advanced Solid Tumors Terminated NCT00003567 Phase 1 O6-benzylguanine;carmustine;temozolomide
45 CD4 Count And Risk Of Infection In Patients With Brain Tumors Completed NCT00999622
46 Identification of Genes Involved in the Pathogenesis of Gliomas by Transcriptome Analysis Completed NCT00967200
47 Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
48 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671
49 Magnetic Resonance Correlates of Glioma Tumor Burden Completed NCT00005082
50 San Francisco Bay Area Adult Glioma Prognosis Study Protocol Completed NCT01009307

Search NIH Clinical Center for Juvenile Pilocytic Astrocytoma

Genetic Tests for Juvenile Pilocytic Astrocytoma

Genetic tests related to Juvenile Pilocytic Astrocytoma:

# Genetic test Affiliating Genes
1 Pilocytic Astrocytoma 29

Anatomical Context for Juvenile Pilocytic Astrocytoma

MalaCards organs/tissues related to Juvenile Pilocytic Astrocytoma:

40
Brain, Spinal Cord, Cerebellum, Pineal, Pituitary, Thyroid, Eye

Publications for Juvenile Pilocytic Astrocytoma

Articles related to Juvenile Pilocytic Astrocytoma:

(show top 50) (show all 1416)
# Title Authors PMID Year
1
RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. 61 6
16247081 2005
2
Impact of morphology, MIB-1, p53 and MGMT on outcome in pilocytic astrocytomas. 54 61
19832838 2010
3
Diversity of glial cell components in pilocytic astrocytoma. 54 61
18312545 2008
4
Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. 54 61
17712732 2007
5
Expression of SOX9 and SOX10 in central neuroepithelial tumor. 54 61
16791471 2006
6
Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. 54 61
16453317 2006
7
Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors. 54 61
15805275 2005
8
Epithelioid glioblastoma: a case report. 54 61
18095100 2005
9
Rosette-forming glioneuronal tumor of the fourth ventricle. 54 61
12915951 2003
10
Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1. 54 61
14565158 2003
11
Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation. 54 61
12902920 2003
12
Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non-infiltrating primary CNS neoplasms. 54 61
11895042 2002
13
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. 54 61
11119125 2000
14
Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. 54 61
9255258 1997
15
[Expression of glial fibrillary acidic protein and protein S-100 in cerebral astrocytic gliomas of varying degrees of malignancy (immunohistochemical study)]. 54 61
8526753 1995
16
The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric population. 61
31677015 2020
17
Posterior fossa tumors in children: Radiological tips & tricks in the age of genomic tumor classification and advance MR technology. 61
31541639 2020
18
Adult Pilocytic Astrocytomas: A Brazilian Series. 61
31550545 2020
19
Functional herniated choroid plexus in brain parenchyma following VP shunt removal. 61
31913712 2020
20
Uptake of Pineal Gland Visible on 18F-DOPA PET/CT With Last Generation of SiPM PET/CT. 61
31348082 2020
21
Role of diffusion weighted imaging for differentiating cerebral pilocytic astrocytoma and ganglioglioma BRAF V600E-mutant from wild type. 61
31667545 2020
22
[Classification of the types of pediatric posterior fossa brain tumors based on routine MRI using wavelet transformation analysis of whole tumor]. 61
32008282 2020
23
Diffusion Tensor Imaging Connectomics Reveals Preoperative Neural Connectivity Changes in Children with Postsurgical Posterior Fossa Syndrome. 61
31908091 2020
24
Deadly Proliferation and Transformation of Pilocytic Astrocytoma in Pregnancy. 61
31574330 2020
25
Rare Case of Sporadic Malignant Optic Pathway Glioma in 71-Year-Old Woman. 61
31336173 2020
26
Dabrafenib in BRAFV600E mutant pilocytic astrocytoma. 61
32002607 2020
27
Keyhole Retrosigmoid Craniotomy for Resection of Pontine Juvenile Pilocytic Astrocytoma: 2-Dimensional Operative Video. 61
31329970 2020
28
Erratum to Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma. 61
31986901 2020
29
Dabrafenib in BRAFV600E mutant pilocytic astrocytoma in a pediatric patient. 61
31418082 2020
30
Brain 123I-FP-CIT SPECT of a Holmes Tremor Due to Midbrain Pilocytic Astrocytoma. 61
31306206 2020
31
Predictive measures and outcomes of extent of resection in juvenile pilocytic astrocytoma. 61
31466905 2019
32
Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma. 61
31032625 2019
33
Supracerebellar Approach to Radiation-Induced Giant Capillary Telangiectasia Within Juvenile Pilocytic Astrocytoma of Upper Brainstem. 61
31479784 2019
34
Purely neuroendoscopic resection of intraventricular tumors with an endoscopic ultrasonic aspirator. 61
30019320 2019
35
A Multi-Institutional Analysis of Factors Influencing Surgical Outcomes for Patients with Newly Diagnosed Grade I Gliomas. 61
31901497 2019
36
Audiovestibular findings in a 6 year old child with pilocytic astrocytoma - a case report. 61
31790608 2019
37
Aberrantly expressed microRNAs and their implications in childhood central nervous system tumors. 61
31797180 2019
38
Extramedullary tanycytic ependymoma of the lumbar spinal cord. 61
31707775 2019
39
Peripheral retinal neovascularization in a patient with pilocytic astrocytoma. 61
31771349 2019
40
Dual BRAF/MEK therapy in BRAF V600E-mutated primary brain tumors: a case series showing dramatic clinical and radiographic responses and a reduction in cutaneous toxicity. 61
31675726 2019
41
Outcomes of stereotactic radiosurgery for pilocytic astrocytoma: an international multiinstitutional study. 61
31783364 2019
42
Immunohistochemical Expression of Epidermal Growth Factor Receptor in Astrocytic Tumors in Iraqi Patients. 61
32010368 2019
43
Experience Profiling of Fluorescence-Guided Surgery I: Gliomas. 61
31686440 2019
44
Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities. 61
31661039 2019
45
Survival and Prognosis of Patients with Pilocytic Astrocytoma: A Single-Center Study. 61
31686439 2019
46
Pilocytic astrocytoma: Where do they belong in cancer reporting? 61
31637436 2019
47
Co-existent pilocytic astrocytoma with acute B-cell leukemia within the cerebellum. 61
31408921 2019
48
Posterior fossa pilocytic astrocytoma presenting with opisthotonus in an infant - A case report. 61
31358429 2019
49
Favorable prognosis in pediatric brainstem low-grade glioma: Report from the German SIOP-LGG 2004 cohort. 61
31613986 2019
50
68Ga-NOTA-Aca-BBN(7-14) PET imaging of GRPR in children with optic pathway glioma. 61
31270559 2019

Variations for Juvenile Pilocytic Astrocytoma

ClinVar genetic disease variations for Juvenile Pilocytic Astrocytoma:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 KRAS NM_033360.4(KRAS):c.37G>C (p.Gly13Arg)SNV Pathogenic 12593 rs121913535 12:25398282-25398282 12:25245348-25245348
2 SDHA NM_004168.4(SDHA):c.91C>T (p.Arg31Ter)SNV Pathogenic 142601 rs142441643 5:223624-223624 5:223509-223509
3 NF1 NM_000267.3(NF1):c.6103A>T (p.Lys2035Ter)SNV Pathogenic 590842 rs1555534667 17:29663671-29663671 17:31336653-31336653
4 FLCN NM_144997.7(FLCN):c.872-1G>TSNV Likely pathogenic 620629 rs1567813248 17:17122524-17122524 17:17219210-17219210
5 PALB2 NM_024675.3(PALB2):c.1478C>T (p.Pro493Leu)SNV Conflicting interpretations of pathogenicity 225853 rs770965402 16:23646389-23646389 16:23635068-23635068
6 APC NM_000038.6(APC):c.1240C>T (p.Arg414Cys)SNV Conflicting interpretations of pathogenicity 797 rs137854567 5:112154969-112154969 5:112819272-112819272
7 RET NM_020975.6(RET):c.1344C>G (p.Asn448Lys)SNV Uncertain significance 136098 rs549907428 10:43606735-43606735 10:43111287-43111287
8 ALK NM_004304.5(ALK):c.2633-3C>TSNV Uncertain significance 620627 rs200341945 2:29451935-29451935 2:29229069-29229069
9 MSH6 NM_000179.2(MSH6):c.188C>G (p.Ser63Cys)SNV Uncertain significance 410430 rs587779920 2:48010560-48010560 2:47783421-47783421
10 RUNX1 NM_001754.4(RUNX1):c.1243C>T (p.Gln415Ter)SNV Uncertain significance 561225 rs1397702481 21:36164632-36164632 21:34792335-34792335

Copy number variations for Juvenile Pilocytic Astrocytoma from CNVD:

7 (show all 22)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 38161 10 1 3000000 Gain DIP2C Pilocytic astrocytoma
2 40599 10 130600000 135534747 Loss DRD1IP Pilocytic astrocytoma
3 64537 12 129300000 133851895 Loss BCL7A Pilocytic astrocytoma
4 84233 14 24600000 33300000 Loss FOXG1B Pilocytic astrocytoma
5 97079 15 98500000 102531392 Loss LASS3 Pilocytic astrocytoma
6 112680 17 40811265 40819024 Loss TUBG2 Pilocytic astrocytoma
7 112684 17 40834631 40852011 Loss CNTNAP1 Pilocytic astrocytoma
8 220399 7 138200000 143100000 Amplification Pilocytic astrocytoma
9 227901 7 72200000 77500000 Loss BCL7B Pilocytic astrocytoma
10 230764 8 1 2200000 Loss Pilocytic astrocytoma
11 234563 8 136400000 146364022 Gain COL22A1 Pilocytic astrocytoma
12 234873 8 139900000 146364022 Gain CYHR1 Pilocytic astrocytoma
13 234878 8 139900000 146364022 Gain FOXH1 Pilocytic astrocytoma
14 234881 8 139900000 146364022 Gain GPT Pilocytic astrocytoma
15 234884 8 139900000 146364022 Gain KIFC2 Pilocytic astrocytoma
16 234886 8 139900000 146364022 Gain LRRC14 Pilocytic astrocytoma
17 234888 8 139900000 146364022 Gain LRRC24 Pilocytic astrocytoma
18 234890 8 139900000 146364022 Gain MFSD3 Pilocytic astrocytoma
19 234893 8 139900000 146364022 Gain PPP1R16A Pilocytic astrocytoma
20 234897 8 139900000 146364022 Gain RECQL4 Pilocytic astrocytoma
21 244900 9 1 2200000 Loss ANKRD15 Pilocytic astrocytoma
22 256191 9 9000000 28000000 Loss SH3GL2 Pilocytic astrocytoma

Expression for Juvenile Pilocytic Astrocytoma

Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

Pathways for Juvenile Pilocytic Astrocytoma

Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 TNC TIMP3 SOX10 PTEN PDGFRB PDGFA
2
Show member pathways
12.93 TNC TIMP3 PTEN PDGFRB PDGFA KRAS
3
Show member pathways
12.81 TNC PTEN PDGFRB PDGFA KRAS FGF2
4
Show member pathways
12.77 PTEN PDGFRB PDGFA KRAS CDK4
5 12.71 PTEN PDGFRB PDGFA KRAS FGF2 CDK4
6 12.68 PDGFRB PDGFA NF1 KRAS FGF2
7
Show member pathways
12.65 PDGFRB PDGFA NF1 KRAS FGF2
8
Show member pathways
12.64 PTEN PDGFRB PDGFA KRAS FGF2
9 12.51 TNC SYP S100B NF1 GFAP
10
Show member pathways
12.44 PTEN PDGFRB PDGFA NF1 KRAS FGF2
11
Show member pathways
12.31 TIMP3 PDGFRB PDGFA KRAS FGF2
12
Show member pathways
12.3 PTEN PDGFRB PDGFA NF1 KRAS FGF2
13 12.29 TNC TIMP3 PTEN PDGFRB PDGFA KRAS
14
Show member pathways
12.17 TIMP3 PDGFRB PDGFA KRAS FGF2
15
Show member pathways
12.15 TIMP3 PTEN KRAS FGF2
16 12.07 PTEN NF1 KRAS CDK4
17
Show member pathways
12.04 PTEN PDGFRB PDGFA KRAS
18 11.79 SOX10 OLIG2 GFAP FGF2
19 11.74 PDGFRB PDGFA KRAS
20 11.71 TNC TIMP3 PDGFRB FGF2
21 11.62 TIMP3 PDGFRB PDGFA KRAS FGF2
22 11.55 PTEN PDGFRB PDGFA NF1 MGMT KRAS
23 11.51 PTEN PDGFRB KRAS IDH1
24 11.19 PDGFRB PDGFA KRAS FGF2
25 11.12 SYP SOX10 S100B PDGFA OLIG2 NES
26 10.9 TNC TIMP3 PDGFRB PDGFA GFAP FGF2

GO Terms for Juvenile Pilocytic Astrocytoma

Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 10.02 SDHA PTEN OLIG2 NES FGF2
2 positive regulation of apoptotic process GO:0043065 9.93 S100B PTEN PDGFRB NF1 CDK4
3 angiogenesis GO:0001525 9.91 PTEN PDGFA FGF2 APOD
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 PTEN PDGFRB PDGFA FGF2
5 MAPK cascade GO:0000165 9.83 PDGFRB PDGFA NF1 KRAS FGF2
6 response to organic substance GO:0010033 9.8 TIMP3 PTEN CDK4
7 response to organic cyclic compound GO:0014070 9.78 PTEN PDGFRB MGMT IDH1
8 response to wounding GO:0009611 9.77 TNC PDGFA GFAP
9 Ras protein signal transduction GO:0007265 9.77 NF1 KRAS FGF2
10 extracellular matrix organization GO:0030198 9.77 TNC PDGFA NF1 GFAP FGF2
11 positive regulation of fibroblast proliferation GO:0048146 9.72 PDGFRB PDGFA CDK4
12 long-term synaptic potentiation GO:0060291 9.7 S100B PTEN GFAP
13 platelet-derived growth factor receptor signaling pathway GO:0048008 9.63 PTEN PDGFRB PDGFA
14 positive regulation of phospholipase C activity GO:0010863 9.62 PDGFRB FGF2
15 negative regulation of protein import into nucleus GO:0042308 9.61 NF1 APOD
16 stem cell proliferation GO:0072089 9.58 NES FGF2
17 forebrain morphogenesis GO:0048853 9.58 PTEN NF1
18 peripheral nervous system axon regeneration GO:0014012 9.56 TNC APOD
19 positive regulation of TRAIL-activated apoptotic signaling pathway GO:1903984 9.51 TIMP3 PTEN
20 regulation of long-term neuronal synaptic plasticity GO:0048169 9.5 SYP NF1 KRAS
21 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 9.49 PDGFRB PDGFA
22 positive regulation of MAP kinase activity GO:0043406 9.46 PDGFRB PDGFA KRAS FGF2
23 regulation of synaptic transmission, GABAergic GO:0032228 9.43 PTEN NF1 KRAS
24 forebrain astrocyte development GO:0021897 9.4 NF1 KRAS
25 wound healing GO:0042060 9.35 TNC PDGFRB PDGFA NF1 FGF2
26 positive regulation of cell proliferation GO:0008284 9.23 TNC S100B PTEN PDGFRB PDGFA KRAS

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor binding GO:0048407 8.96 PDGFRB PDGFA
2 platelet-derived growth factor receptor binding GO:0005161 8.8 PTEN PDGFRB PDGFA

Sources for Juvenile Pilocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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