MCID: JVN047
MIFTS: 26

Juvenile Spondyloarthropathy

Categories: Rare diseases, Genetic diseases, Bone diseases

Aliases & Classifications for Juvenile Spondyloarthropathy

MalaCards integrated aliases for Juvenile Spondyloarthropathy:

Name: Juvenile Spondyloarthropathy 53 73

Classifications:



External Ids:

UMLS 73 C0409676

Summaries for Juvenile Spondyloarthropathy

NIH Rare Diseases : 53 Juvenile spondyloarthropathy refers to a group of rheumatic diseases that develop during childhood and are characterized by inflammation of the entheses (the regions where tendons or ligaments attach to bones) and joints. The joints of the lower extremities are generally affected first followed by the sacroiliac joints (between the pelvis and the spine) and spinal joints some years later. Signs and symptoms may include pain and swelling of the affected entheses and joints that may be misdiagnosed and treated as an injury. The underlying cause of juvenile spondyloarthropathy is currently unknown; however, the condition is strongly associated with HLA-B27. Some cases appear to occur sporadically while other affected people have a family history of arthritis, or other related condition. Treatment varies based on the type of juvenile spondyloarthropathy but may include various medications.

MalaCards based summary : Juvenile Spondyloarthropathy is related to spondyloarthropathy and arthritis. An important gene associated with Juvenile Spondyloarthropathy is IL2 (Interleukin 2), and among its related pathways/superpathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Allograft rejection. The drugs Infliximab and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Juvenile Spondyloarthropathy

Diseases in the Spondyloarthropathy family:

Spondyloarthropathy 1 Spondyloarthropathy 2
Spondyloarthropathy 3 Juvenile Spondyloarthropathy

Diseases related to Juvenile Spondyloarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 10.4
2 arthritis 10.2
3 rheumatoid arthritis 10.1
4 juvenile rheumatoid arthritis 10.1
5 uveitis 10.0
6 familial mediterranean fever 9.7
7 brucellosis 9.7
8 sapho syndrome 9.7
9 aneurysm 9.7
10 streptococcal toxic-shock syndrome 9.7 IL2 LTA
11 necrotizing fasciitis 9.7 IL2 LTA
12 tonsillitis 9.7 IL2 LTA
13 toxic shock syndrome 9.6 IL2 LTA
14 tetanus 9.6 IL2 LTA
15 behcet syndrome 9.6 IL2 LTA
16 t-cell leukemia 9.6 IL2 LTA
17 human immunodeficiency virus type 1 9.6 IL2 LTA
18 multiple sclerosis 9.5 IL2 LTA
19 psoriasis 9.5 IL2 LTA
20 malaria 9.4 IL2 LTA
21 inflammatory bowel disease 9.3 IL2 LTA
22 systemic lupus erythematosus 9.2 IL2 LTA
23 diabetes mellitus 9.0 IL2 LTA

Graphical network of the top 20 diseases related to Juvenile Spondyloarthropathy:



Diseases related to Juvenile Spondyloarthropathy

Symptoms & Phenotypes for Juvenile Spondyloarthropathy

Drugs & Therapeutics for Juvenile Spondyloarthropathy

Drugs for Juvenile Spondyloarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 2, Phase 3 170277-31-3
2 Gastrointestinal Agents Phase 2, Phase 3
3 Dermatologic Agents Phase 2, Phase 3
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Antirheumatic Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy, Safety, and Tolerability Study of Infliximab in Juvenile Spondyloarthropathies Completed NCT00591201 Phase 2, Phase 3 infliximab;Placebo
2 German Spondyloarthritis Inception Cohort Recruiting NCT01277419

Search NIH Clinical Center for Juvenile Spondyloarthropathy

Genetic Tests for Juvenile Spondyloarthropathy

Anatomical Context for Juvenile Spondyloarthropathy

MalaCards organs/tissues related to Juvenile Spondyloarthropathy:

41
Bone

Publications for Juvenile Spondyloarthropathy

Articles related to Juvenile Spondyloarthropathy:

(show all 23)
# Title Authors Year
1
Comparison of patients with familial Mediterranean fever accompanied with sacroiliitis and patients with juvenile spondyloarthropathy. ( 28980897 )
2017
2
Juvenile spondyloarthropathy: an important clinical lesson to remember. ( 26677159 )
2015
3
Magnetic resonance imaging findings in juvenile spondyloarthropathy and effects of treatment observed on subsequent imaging. ( 25067925 )
2014
4
Progressive bilateral lipoma arborescens of the knee complicated by juvenile spondyloarthropathy: a case report and review of the literature. ( 23352250 )
2013
5
Diagnosis and treatment of juvenile spondyloarthropathy and related diseases. ( 23814933 )
2012
6
Tarsitis as an initial manifestation of juvenile spondyloarthropathy. ( 19772808 )
2009
7
HLA-B*27/HLA-B*07 in combination with D6S273-134 allele is associated with increased susceptibility to juvenile spondyloarthropathies. ( 18578977 )
2008
8
Radiographic and clinical outcome in early juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3-year prospective study. ( 16758503 )
2006
9
Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study. ( 15940778 )
2005
10
Juvenile spondyloarthropathy. ( 12819463 )
2003
11
Recurrent uveitis in a patient with juvenile spondyloarthropathy associated with tumour necrosis factor alpha inhibitors. ( 12480683 )
2003
12
Prognosis of patients with juvenile chronic arthritis and juvenile spondyloarthropathy. ( 10990244 )
2000
13
Pulmonary function in children affected by juvenile spondyloarthropathy. ( 10381060 )
1999
14
Aerobic fitness and physical activity in patients with HLA-B27 positive juvenile spondyloarthropathy that is inactive or in remission. ( 9712111 )
1998
15
Outcome and predictive factors in juvenile rheumatoid arthritis and juvenile spondyloarthropathy. ( 9489836 )
1998
16
Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: prominence of interleukin 4 in restricted disease. ( 9676774 )
1998
17
Aneurysmal dilatation of ascending aorta and aortic insufficiency in juvenile spondyloarthropathy. ( 9225879 )
1997
18
Identification of childhood arthritis in archaeological material: juvenile rheumatoid arthritis versus juvenile spondyloarthropathy. ( 9066903 )
1997
19
Enteropathic arthritis, Whipple's disease, juvenile spondyloarthropathy, uveitis, and SAPHO syndrome. ( 7547105 )
1995
20
Enteropathic arthritis, Whipple's disease, juvenile spondyloarthropathy, and uveitis. ( 7520727 )
1994
21
Juvenile rheumatoid arthritis, juvenile chronic arthritis, and juvenile spondyloarthropathies. ( 1419506 )
1992
22
Juvenile chronic arthritis and juvenile spondyloarthropathy. ( 1751317 )
1991
23
Tarsometatarsal involvement in juvenile spondyloarthropathy. ( 2265814 )
1990

Variations for Juvenile Spondyloarthropathy

Expression for Juvenile Spondyloarthropathy

Search GEO for disease gene expression data for Juvenile Spondyloarthropathy.

Pathways for Juvenile Spondyloarthropathy

Pathways related to Juvenile Spondyloarthropathy according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 IL2 LTA
2
Show member pathways
12.24 IL2 LTA
3
Show member pathways
12.15 IL2 LTA
4
Show member pathways
12.05 IL2 LTA
5
Show member pathways
12 IL2 LTA
6 11.77 IL2 LTA
7
Show member pathways
11.6 IL2 LTA
8
Show member pathways
11.18 IL2 LTA
9 11.06 IL2 LTA
10
Show member pathways
10.78 IL2 LTA
11 10.04 IL2 LTA

GO Terms for Juvenile Spondyloarthropathy

Biological processes related to Juvenile Spondyloarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.26 IL2 LTA
2 regulation of signaling receptor activity GO:0010469 9.16 IL2 LTA
3 cell-cell signaling GO:0007267 8.96 IL2 LTA
4 positive regulation of interferon-gamma production GO:0032729 8.62 IL2 LTA

Molecular functions related to Juvenile Spondyloarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 IL2 LTA

Sources for Juvenile Spondyloarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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