MCID: JVN047
MIFTS: 24

Juvenile Spondyloarthropathy

Categories: Bone diseases, Eye diseases, Genetic diseases, Immune diseases, Muscle diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Juvenile Spondyloarthropathy

MalaCards integrated aliases for Juvenile Spondyloarthropathy:

Name: Juvenile Spondyloarthropathy 20 70

Classifications:



External Ids:

UMLS 70 C0409676

Summaries for Juvenile Spondyloarthropathy

GARD : 20 Juvenile spondyloarthropathy refers to a group of rheumatic diseases that develop during childhood and are characterized by inflammation of the entheses (the regions where tendons or ligaments attach to bones) and joints. The joints of the lower extremities are generally affected first followed by the sacroiliac joints (between the pelvis and the spine) and spinal joints some years later. Signs and symptoms may include pain and swelling of the affected entheses and joints that may be misdiagnosed and treated as an injury. The underlying cause of juvenile spondyloarthropathy is currently unknown; however, the condition is strongly associated with HLA-B27. Some cases appear to occur sporadically while other affected people have a family history of arthritis, or other related condition. Treatment varies based on the type of juvenile spondyloarthropathy but may include various medications.

MalaCards based summary : Juvenile Spondyloarthropathy is related to spondyloarthropathy and juvenile rheumatoid arthritis. An important gene associated with Juvenile Spondyloarthropathy is IL2 (Interleukin 2), and among its related pathways/superpathways are Allograft rejection and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Infliximab and Pharmaceutical Solutions have been mentioned in the context of this disorder.

Related Diseases for Juvenile Spondyloarthropathy

Diseases in the Spondyloarthropathy family:

Spondyloarthropathy 1 Spondyloarthropathy 2
Spondyloarthropathy 3 Juvenile Spondyloarthropathy

Diseases related to Juvenile Spondyloarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 30.6 LTA IL2
2 juvenile rheumatoid arthritis 30.1 LTA IL2
3 uveitis 29.9 LTA IL2
4 fasciitis 29.6 LTA IL2
5 posterior uveitis 29.6 LTA IL2
6 inflammatory spondylopathy 10.3
7 spondylitis 10.3
8 spondyloarthropathy 1 10.2
9 arthropathy 10.2
10 familial mediterranean fever 10.1
11 brucellosis 10.1
12 juvenile arthritis 10.0
13 enthesopathy 10.0
14 lipomatosis, multiple 9.9
15 systemic lupus erythematosus 9.9
16 juvenile ankylosing spondylitis 9.9
17 autosomal recessive disease 9.9
18 pleomorphic lipoma 9.9
19 sapho syndrome 9.9
20 arthritis 9.9
21 lupus erythematosus 9.9
22 plantar fasciitis 9.9
23 cytokine deficiency 9.9
24 back pain 9.9
25 streptococcal toxic-shock syndrome 9.8 LTA IL2
26 necrotizing fasciitis 9.8 LTA IL2
27 tonsillitis 9.8 LTA IL2
28 chronic fatigue syndrome 9.8 LTA IL2
29 toxic shock syndrome 9.8 LTA IL2
30 myasthenia gravis 9.8 LTA IL2
31 visceral leishmaniasis 9.8 LTA IL2
32 tetanus 9.8 LTA IL2
33 sarcoidosis 1 9.8 LTA IL2
34 psoriatic arthritis 9.8 LTA IL2
35 behcet syndrome 9.8 LTA IL2
36 disease by infectious agent 9.8 LTA IL2
37 t-cell lymphoblastic leukemia/lymphoma 9.8 LTA IL2
38 dermatitis, atopic 9.7 LTA IL2
39 human immunodeficiency virus type 1 9.7 LTA IL2
40 aplastic anemia 9.7 LTA IL2
41 autoimmune disease 9.7 LTA IL2
42 immune deficiency disease 9.7 LTA IL2
43 leukemia, chronic lymphocytic 9.6 LTA IL2
44 psoriasis 9.6 LTA IL2
45 multiple sclerosis 9.5 LTA IL2

Graphical network of the top 20 diseases related to Juvenile Spondyloarthropathy:



Diseases related to Juvenile Spondyloarthropathy

Symptoms & Phenotypes for Juvenile Spondyloarthropathy

Drugs & Therapeutics for Juvenile Spondyloarthropathy

Drugs for Juvenile Spondyloarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 2, Phase 3 170277-31-3
2 Pharmaceutical Solutions Phase 2, Phase 3
3 Antirheumatic Agents Phase 2, Phase 3
4 Dermatologic Agents Phase 2, Phase 3
5 Gastrointestinal Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy, Safety, and Tolerability of Infliximab (Remicade; Schering-Plough) in Juvenile Spondyloarthropathies: a Three-Month, Randomized, Double-Blind, Placebo-Controlled Trial and 52-Week Open Extension. Completed NCT00591201 Phase 2, Phase 3 infliximab;Placebo

Search NIH Clinical Center for Juvenile Spondyloarthropathy

Genetic Tests for Juvenile Spondyloarthropathy

Anatomical Context for Juvenile Spondyloarthropathy

Publications for Juvenile Spondyloarthropathy

Articles related to Juvenile Spondyloarthropathy:

(show top 50) (show all 60)
# Title Authors PMID Year
1
Unexpected increase of aortic stiffness in juvenile Spondyloarthropathies. 61
32938508 2020
2
Evaluation of familial Mediterranean fever patients concomitant with juvenile spondyloarthropathy. 61
32815445 2020
3
Management of juvenile spondyloarthropathy through Ayurveda:- a case report. 61
32768345 2020
4
Coexistence of Juvenile Systemic Lupus Erythematosus and Juvenile Spondyloarthropathy: A Case Report and Review of the Literature. 61
32637929 2020
5
Similarities between pediatric FMF patients with sacroiliitis and pediatric juvenile spondyloarthropathy patients with sacroiliitis: a preliminary study. 61
32009575 2020
6
The frequency of uveitis in patients with juvenile inflammatory rheumatic diseases. 61
31207292 2019
7
Enthesitis-related arthritis: current perspectives. 61
30774484 2019
8
Comparison of patients with familial Mediterranean fever accompanied with sacroiliitis and patients with juvenile spondyloarthropathy. 61
28980897 2017
9
Juvenile spondyloarthropathy: an important clinical lesson to remember. 61
26677159 2015
10
Enthesitis-related arthritis. 61
26233720 2015
11
Enthesitis-related arthritis: time to re-define? 61
25366933 2014
12
Magnetic resonance imaging findings in juvenile spondyloarthropathy and effects of treatment observed on subsequent imaging. 61
25067925 2014
13
Radiological imaging in pediatric rheumatic diseases. 61
24669280 2014
14
Progressive bilateral lipoma arborescens of the knee complicated by juvenile spondyloarthropathy: a case report and review of the literature. 61
23352250 2013
15
Diagnostic imaging of sacroiliac joints and the spine in the course of spondyloarthropathies. 61
23807884 2013
16
Diagnosis and treatment of juvenile spondyloarthropathy and related diseases. 61
23814933 2012
17
Juvenile spondyloarthropathies. 61
22911266 2012
18
Human leukocyte antigen B27 in 453 Asian Indian patients with seronegative spondyloarthropathy. 61
21189449 2010
19
Massive bilateral tarsal ankylosis and surgical correction: a case report. 61
20494593 2010
20
Tarsitis as an initial manifestation of juvenile spondyloarthropathy. 61
19772808 2009
21
Sacroiliac joint pathologies in low back pain. 61
20023336 2009
22
Is HLA-B27 a useful test in the diagnosis of juvenile spondyloarthropathies? 61
18946613 2008
23
Radiographic and clinical outcome in early juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3-year prospective study. 61
16758503 2006
24
Juvenile spondyloarthropathies associated with Mycoplasma pneumoniae infection. 61
16391883 2006
25
Radiologic Improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. 61
16755667 2006
26
Optic neuritis associated with etanercept therapy for juvenile arthritis. 61
16527676 2006
27
Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study. 61
15940778 2005
28
Evaluation of revised International League of Associations for Rheumatology classification criteria for juvenile idiopathic arthritis in Spanish children (Edmonton 2001). 61
15742453 2005
29
Joint lavage for treating recurrent knee involvement in patients with juvenile idiopathic arthritis. 61
15288854 2004
30
Relationship of psoriatic arthritis with the other spondyloarthropathies. 61
15201595 2004
31
Juvenile spondyloarthropathy. 61
12819463 2003
32
[Sacroiliitis in children with spondyloarthropathy: therapeutic effect of CT-Guided intra-articular corticosteroid injection]. 61
12811695 2003
33
Treatment of refractory juvenile idiopathic arthritis via pulse therapy using methylprednisolone and cyclophosphamide. 61
12920473 2003
34
Remission in juvenile chronic arthritis: a cohort study of 683 consecutive cases with a mean 10 year followup. 61
12610820 2003
35
Recurrent uveitis in a patient with juvenile spondyloarthropathy associated with tumour necrosis factor alpha inhibitors. 61
12480683 2003
36
[Seronegative spondyloarthropathies]. 61
12428438 2002
37
Health care provision in pediatric rheumatology in Germany--national rheumatologic database. 61
11908581 2002
38
Evaluation of ILAR classification criteria for juvenile idiopathic arthritis in Spanish children. 61
11764225 2001
39
Prognosis of patients with juvenile chronic arthritis and juvenile spondyloarthropathy. 61
10990244 2000
40
Non-infectious causes of uveitis in 70 Swiss children. 61
10976838 2000
41
Juvenile spondyloarthropathies. 61
10910178 2000
42
Cardiac manifestations in patients with HLA B27-associated juvenile arthritis. 61
10754085 2000
43
Ocular manifestations in children and adolescents with Lyme arthritis. 61
10502576 1999
44
Recognition and treatment of arthritis in children. 61
10470519 1999
45
Pulmonary function in children affected by juvenile spondyloarthropathy. 61
10381060 1999
46
Aerobic fitness and physical activity in patients with HLA-B27 positive juvenile spondyloarthropathy that is inactive or in remission. 61
9712111 1998
47
Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: prominence of interleukin 4 in restricted disease. 61
9676774 1998
48
Outcome and predictive factors in juvenile rheumatoid arthritis and juvenile spondyloarthropathy. 61
9489836 1998
49
Identification of childhood arthritis in archaeological material: juvenile rheumatoid arthritis versus juvenile spondyloarthropathy. 61
9066903 1997
50
Aneurysmal dilatation of ascending aorta and aortic insufficiency in juvenile spondyloarthropathy. 61
9225879 1997

Variations for Juvenile Spondyloarthropathy

Expression for Juvenile Spondyloarthropathy

Search GEO for disease gene expression data for Juvenile Spondyloarthropathy.

Pathways for Juvenile Spondyloarthropathy

Pathways related to Juvenile Spondyloarthropathy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.24 LTA IL2
2
Show member pathways
12.15 LTA IL2
3
Show member pathways
12.08 LTA IL2
4 11.74 LTA IL2
5
Show member pathways
11.7 LTA IL2
6
Show member pathways
11.64 LTA IL2
7
Show member pathways
11.24 LTA IL2
8 11.16 LTA IL2
9
Show member pathways
11.04 LTA IL2
10
Show member pathways
10.78 LTA IL2
11 10.41 LTA IL2
12 10.04 LTA IL2

GO Terms for Juvenile Spondyloarthropathy

Biological processes related to Juvenile Spondyloarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.16 LTA IL2
2 cell-cell signaling GO:0007267 8.96 LTA IL2
3 positive regulation of interferon-gamma production GO:0032729 8.62 LTA IL2

Molecular functions related to Juvenile Spondyloarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 LTA IL2

Sources for Juvenile Spondyloarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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