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MCID: JVN002
MIFTS: 35

Juvenile Type Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Juvenile Type Testicular Granulosa Cell Tumor

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MalaCards integrated aliases for Juvenile Type Testicular Granulosa Cell Tumor:

Name: Juvenile Type Testicular Granulosa Cell Tumor 12 15 71
Juvenile Granulosa Cell Tumor 12 71
Juvenile Type Testicular Granulosa Cell Tumour 12
Juvenile Type Granulosa Cell Neoplasm 12
Juvenile Type Granulosa Cell Tumour 12
Juvenile Type Granulosa Cell Tumor 12
Juvenile Granulosa Cell Tumour 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6032
NCIt 49 C39947 C4207
SNOMED-CT 67 77029009
UMLS 71 C0334403 C1515285
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Summaries for Juvenile Type Testicular Granulosa Cell Tumor

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MalaCards based summary : Juvenile Type Testicular Granulosa Cell Tumor, also known as juvenile granulosa cell tumor, is related to gynandroblastoma and luteoma. An important gene associated with Juvenile Type Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and BRCA1 Pathway. Affiliated tissues include ovary, testis and testes, and related phenotypes are endocrine/exocrine gland and liver/biliary system

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Related Diseases for Juvenile Type Testicular Granulosa Cell Tumor

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Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Juvenile Type Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 30.7 FOXL2 DICER1 CALB2
2 luteoma 30.6 FOXL2 CALB2
3 cystic lymphangioma 30.5 CALB2 AFP
4 mixed gonadal dysgenesis 30.5 MIR302C FOXL2
5 benign mesothelioma 30.2 WT1 CALB2 AFP
6 sertoli cell tumor 30.1 WT1 CALB2 AFP
7 leydig cell tumor 29.9 GNAS CALB2 AFP
8 ovarian cyst 29.9 GNAS FOXL2 AFP
9 small cell carcinoma 29.9 WT1 SMARCA4 SMARCA2
10 teratoma 29.6 SMARCB1 CD99 CALB2 AFP
11 sertoli-leydig cell tumor 29.4 WT1 MIR302C FOXL2 DICER1 CALB2 AFP
12 granulosa cell tumor of the ovary 10.8
13 precocious puberty 10.5
14 rare tumor 10.4
15 maligant granulosa cell tumor of the ovary 10.4 FOXL2 DICER1
16 corpus luteum cyst 10.4 FOXL2 AFP
17 enchondromatosis, multiple, ollier type 10.4
18 rete testis neoplasm 10.4 CALB2 AFP
19 rete testis adenocarcinoma 10.4 CALB2 AFP
20 dermoid cyst of ovary 10.4 CALB2 AFP
21 papillary thymic adenocarcinoma 10.4 CALB2 AFP
22 infected hydrocele 10.4 CALB2 AFP
23 hydrocele 10.4 CALB2 AFP
24 non-gestational choriocarcinoma 10.4 MIR302C AFP
25 pediatric germ cell cancer 10.3 MIR302C AFP
26 adenofibroma 10.3 WT1 CALB2
27 fallopian tube carcinosarcoma 10.3 WT1 CALB2
28 botryoid rhabdomyosarcoma 10.3 DICER1 AFP
29 choriocarcinoma of the testis 10.3 INTS13 AFP
30 wolffian duct adenocarcinoma 10.3 WT1 CALB2
31 malignant biphasic mesothelioma 10.3 WT1 CALB2
32 endodermal sinus tumor 10.3
33 testicular yolk sac tumor 10.3
34 pericardium cancer 10.3 WT1 CALB2
35 ovarian endometrioid stromal sarcoma 10.3 WT1 CALB2
36 endosalpingiosis 10.3 WT1 CALB2
37 chondrodysplasia-pseudohermaphroditism syndrome 10.3 WT1 FOXL2
38 ovarian mixed germ cell neoplasm 10.3 WT1 AFP
39 endometrioid ovary carcinoma 10.2 WT1 SMARCA4
40 peritoneal serous adenocarcinoma 10.2 WT1 CALB2
41 kidney sarcoma 10.2 WT1 DICER1
42 benign peritoneal mesothelioma 10.2 WT1 CALB2
43 middle ear carcinoma 10.2 WT1 AFP
44 amenorrhea 10.2
45 adult type testicular granulosa cell tumor 10.2 FOXL2 CALB2 AFP
46 heart cancer 10.2 WT1 CALB2
47 mature teratoma 10.2 MIR302C AFP
48 ovarian germ cell teratoma 10.2 MIR302C CALB2 AFP
49 wilms tumor predisposition 10.2 WT1 DICER1
50 ovarian germ cell cancer 10.2 MIR302C CALB2 AFP

Graphical network of the top 20 diseases related to Juvenile Type Testicular Granulosa Cell Tumor:



Diseases related to Juvenile Type Testicular Granulosa Cell Tumor
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Symptoms & Phenotypes for Juvenile Type Testicular Granulosa Cell Tumor

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MGI Mouse Phenotypes related to Juvenile Type Testicular Granulosa Cell Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 AFP BMPR1B DICER1 FOXL2 GNAS SMARCA2
2 liver/biliary system MP:0005370 9.8 AFP DICER1 GNAS SMARCA4 SMARCB1 WT1
3 muscle MP:0005369 9.73 DICER1 GNAS SMARCA2 SMARCA4 SMARCB1 WT1
4 neoplasm MP:0002006 9.7 AFP DICER1 GNAS SMARCA2 SMARCA4 SMARCB1
5 normal MP:0002873 9.5 BMPR1B CALB2 DICER1 FOXL2 GNAS SMARCA4
6 reproductive system MP:0005389 9.17 AFP BMPR1B DICER1 FOXL2 SMARCA2 SMARCB1
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Drugs & Therapeutics for Juvenile Type Testicular Granulosa Cell Tumor

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Juvenile Type Testicular Granulosa Cell Tumor

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Genetic Tests for Juvenile Type Testicular Granulosa Cell Tumor

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Anatomical Context for Juvenile Type Testicular Granulosa Cell Tumor

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MalaCards organs/tissues related to Juvenile Type Testicular Granulosa Cell Tumor:

40
Ovary, Testis, Testes, Bone Marrow, Bone, Lymph Node, Smooth Muscle
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Publications for Juvenile Type Testicular Granulosa Cell Tumor

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Articles related to Juvenile Type Testicular Granulosa Cell Tumor:

(show top 50) (show all 197)
# Title Authors PMID Year
1
Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature. 61
32144835 2020
2
Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case. 61
32341591 2020
3
Multiple Luteinized Follicle Cysts of the Ovary in a Patient With a Pituitary Adenoma: Report of a Case and Review of the Literature. 61
30358638 2019
4
Malignant Sex Cord-Stromal Tumor, Not Otherwise Specified, Harboring FOXL2, p53, and TERT Promoter Mutations: Report of a Case. 61
31789679 2019
5
Adult Granulosa Cell Tumor With High-grade Transformation: Report of a Series With FOXL2 Mutation Analysis. 61
31162286 2019
6
Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty. 61
31582893 2019
7
Juvenile granulosa cell tumor associated with Maffucci syndrome in pregnancy: A case report. 61
30965205 2019
8
A Rare Case of Uterine Torsion With Juvenile Granulosa Cell Tumor in the Pediatric Patient. 61
30796991 2019
9
Outcomes of fertility-sparing surgery in ovarian juvenile granulosa cell tumor. 61
30728165 2019
10
Juvenile Granulosa Cell Tumor of the Testis: Prenatal Diagnosis and Management. 61
31871849 2019
11
Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD. 61
30500284 2018
12
Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature. 61
30547828 2018
13
Multimodal molecular analysis of an atypical small cell carcinoma of the ovary, hypercalcemic type. 61
30275002 2018
14
Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review. 61
30011982 2018
15
Granulosa-cell tumor after ovarian stimulation: A case report. 61
30123871 2018
16
A rare case report of ovarian juvenile granulosa cell tumor with massive ascites as the first sign, and review of literature: Case report and review of literature. 61
29923976 2018
17
The molecular mechanism of ovarian granulosa cell tumors. 61
29409506 2018
18
Juvenile Granulosa Cell Tumor of the Testicle - Report of a Neonatal Case with Positive Alpha-fetoprotein Immunohistochemical Staining. 61
28331810 2017
19
The association of enchondromatosis with malignant transformed chondrosarcoma and ovarian juvenile granulosa cell tumor (Ollier disease). 61
28420520 2017
20
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. 61
27702598 2017
21
Spontaneous regression of suspected cystic dysplasia of the rete testis in three neonates. 61
27372158 2016
22
Long-term survival in a patient with an advanced ovarian juvenile granulosa cell tumor with para-aortic lymph node metastasis. 61
28040149 2016
23
Juvenile granulosa cell tumor associated with Ollier disease. 61
28144098 2016
24
Juvenile granulosa cell tumor of the testis in a newborn. 61
27569101 2016
25
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric ovarian tumors: a novel treatment approach. 61
26500075 2016
26
[Peripheral precocious puberty]. 61
27897024 2016
27
[Recurrence occurring ten years after the initial diagnosis of granulosa cell tumour of the ovary: about two cases and review of the literatur]. 61
28154722 2016
28
Long-term Remission in a Female With Multiple Relapsed Juvenile Granulosa Cell Tumor. 61
26165406 2015
29
SMARCA4-deficient undifferentiated carcinoma of the ovary (small cell carcinoma, hypercalcemic type): clinicopathologic and immunohistochemical study of 3 cases. 61
26123103 2015
30
Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. 61
26169919 2015
31
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases. 61
25828390 2015
32
Ovarian sex cord-stromal tumors in patients with probable or confirmed germline DICER1 mutations. 61
25844550 2015
33
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. 61
25656930 2015
34
Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. 61
25165122 2014
35
Juvenile granulosa cell tumor of the testis: a bilateral and synchronous case. Should testis-sparing surgery be mandatory? 61
25053523 2014
36
Ovarian tumors and tumor-like lesions in the first three decades. 61
25440719 2014
37
Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades. 61
25440720 2014
38
Juvenile granulosa cell tumor of the testis. 61
25148497 2014
39
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. 61
24656706 2014
40
Ovarian juvenile granulosa cell tumor in a 20-month-old infant. 61
25266542 2014
41
Juvenile granulosa cell tumors: immunoreactivity for CD99 and Fli-1 and EWSR1 translocation status: a study of 11 cases. 61
24300529 2014
42
Granulosa cell tumor of the testis in a newborn. 61
28652991 2014
43
Juvenile granulosa cell tumor with an unusual immunoprofile, presenting as precocious puberty. 61
24455600 2013
44
FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines. 61
23348906 2013
45
Paraneoplastic hypercalcemia associated with juvenile granulosa cell tumor. 61
23519754 2013
46
Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature. 61
23776871 2013
47
Hypercalcemia in a child with juvenile granulosa cell tumor of ovary: Report of an unusual paraneoplastic syndrome and review of the literature. 61
24371683 2013
48
Central precocious puberty and granulosa cell ovarian tumor in an 8-year old female. 61
24198925 2013
49
Massive ascites as the only sign of ovarian juvenile granulosa cell tumor in an adolescent: a case report and a review of the literature. 61
23424695 2013
50
Juvenile granulosa cell tumor of the testis: prenatal diagnosis and prescrotal approach. 61
23217189 2012
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Variations for Juvenile Type Testicular Granulosa Cell Tumor

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Expression for Juvenile Type Testicular Granulosa Cell Tumor

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Search GEO for disease gene expression data for Juvenile Type Testicular Granulosa Cell Tumor.
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Pathways for Juvenile Type Testicular Granulosa Cell Tumor

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Pathways related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 64
11.56 WT1 SMARCA4 AFP
2
BRCA1 Pathway 63
Show member pathways
 11.25 SMARCB1 SMARCA4 SMARCA2
3
AMPK Enzyme Complex Pathway 63
Show member pathways
 11.16 SMARCB1 SMARCA4 SMARCA2 GNAS
4
Transcription Ligand-dependent activation of the ESR1/SP pathway 22
Show member pathways
 10.98 SMARCB1 SMARCA4 SMARCA2
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GO Terms for Juvenile Type Testicular Granulosa Cell Tumor

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Cellular components related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.56 GNAS DICER1 CALB2 BMPR1B
2 SWI/SNF complex GO:0016514 9.33 SMARCB1 SMARCA4 SMARCA2
3 nBAF complex GO:0071565 9.13 SMARCB1 SMARCA4 SMARCA2
4 npBAF complex GO:0071564 8.8 SMARCB1 SMARCA4 SMARCA2

Biological processes related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.91 WT1 SMARCB1 SMARCA4 SMARCA2 FOXL2
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.88 WT1 SMARCA4 SMARCA2 FOXL2 DICER1
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 WT1 SMARCB1 SMARCA4 SMARCA2 FOXL2 BMPR1B
4 negative regulation of cell growth GO:0030308 9.61 WT1 SMARCA4 SMARCA2
5 chromatin remodeling GO:0006338 9.54 SMARCB1 SMARCA4 SMARCA2
6 nucleosome disassembly GO:0006337 9.49 SMARCB1 SMARCA4
7 positive regulation by host of viral transcription GO:0043923 9.46 SMARCB1 SMARCA4
8 apoptotic DNA fragmentation GO:0006309 9.4 FOXL2 DICER1
9 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.26 SMARCB1 SMARCA4
10 RNA polymerase I preinitiation complex assembly GO:0001188 9.16 SMARCB1 SMARCA4
11 positive regulation of glucose mediated signaling pathway GO:1902661 8.96 SMARCB1 SMARCA4
12 ATP-dependent chromatin remodeling GO:0043044 8.8 SMARCB1 SMARCA4 SMARCA2

Molecular functions related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 helicase activity GO:0004386 9.43 SMARCA4 SMARCA2 DICER1
2 Tat protein binding GO:0030957 9.16 SMARCB1 SMARCA4
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.96 SMARCA4 SMARCA2
4 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 8.62 SMARCB1 SMARCA4
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Sources for Juvenile Type Testicular Granulosa Cell Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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