MCID: JVN002
MIFTS: 36

Juvenile Type Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Juvenile Type Testicular Granulosa Cell Tumor:

Name: Juvenile Type Testicular Granulosa Cell Tumor 12 15 73
Juvenile Granulosa Cell Tumor 12 73
Juvenile Type Granulosa Cell Neoplasm 12
Juvenile Type Granulosa Cell Tumor 12
Juvenile Granulosa Cell Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6032
NCIt 50 C39947 C4207
SNOMED-CT 68 77029009

Summaries for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards based summary : Juvenile Type Testicular Granulosa Cell Tumor, also known as juvenile granulosa cell tumor, is related to gynandroblastoma and granulosa cell tumor of the ovary. An important gene associated with Juvenile Type Testicular Granulosa Cell Tumor is PTH1R (Parathyroid Hormone 1 Receptor), and among its related pathways/superpathways are Direct p53 effectors and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary, testis and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Juvenile Type Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Juvenile Type Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 30.4 DICER1 FOXL2
2 granulosa cell tumor of the ovary 10.7
3 enchondromatosis, multiple, ollier type 10.3
4 precocious puberty 10.2
5 maligant granulosa cell tumor of the ovary 10.0 DICER1 FOXL2
6 ovarian small cell carcinoma 10.0 SMARCA4 WT1
7 insulin-like growth factor i 10.0
8 rhabdoid cancer 10.0 SMARCA4 WT1
9 renal cell carcinoma, nonpapillary 10.0
10 chondrosarcoma 10.0
11 aromatase deficiency 10.0
12 hyperprolactinemia 10.0
13 tuberous sclerosis 10.0
14 amenorrhea 10.0
15 adenosarcoma 10.0
16 hermaphroditism 10.0
17 triploidy 10.0
18 central precocious puberty 10.0
19 kidney sarcoma 10.0 DICER1 WT1
20 cystic nephroma 10.0 DICER1 WT1
21 gonadoblastoma 10.0 FOXL2 WT1
22 kidney benign neoplasm 9.9 DICER1 WT1
23 tumor predisposition syndrome 9.9 DICER1 SMARCA4
24 corpus luteum cyst 9.9 AFP FOXL2
25 gonadal dysgenesis 9.9 FOXL2 WT1
26 dysgerminoma 9.9 AFP WT1
27 ovarian cyst 9.9 AFP FOXL2
28 adenomatoid tumor 9.9 AFP WT1
29 reproductive organ benign neoplasm 9.9 AFP DICER1
30 nephrotic syndrome, type 1 9.9 AFP WT1
31 premature ovarian failure 1 9.8 FOXL2 WT1
32 pineoblastoma 9.8 AFP DICER1
33 gonadal disease 9.8 AFP FOXL2
34 testicular disease 9.8 AFP DICER1
35 sertoli-leydig cell tumor 9.7 AFP DICER1 WT1
36 dysgerminoma of ovary 9.7 AFP DICER1 WT1
37 male reproductive organ benign neoplasm 9.5 AFP DICER1 FOXL2 WT1
38 sex cord-gonadal stromal tumor 9.5 AFP DICER1 FOXL2 WT1
39 testicular granulosa cell tumor 9.2 AFP DICER1 FOXL2 PTH1R SMARCA4 WT1

Graphical network of the top 20 diseases related to Juvenile Type Testicular Granulosa Cell Tumor:



Diseases related to Juvenile Type Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Juvenile Type Testicular Granulosa Cell Tumor

GenomeRNAi Phenotypes related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.5 AFP FOXL2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.5 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.5 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.5 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.5 AFP FOXL2
6 shRNA abundance <= 50% GR00343-S 9.02 DICER1 FOXL2 PTH1R SMARCA4 WT1

MGI Mouse Phenotypes related to Juvenile Type Testicular Granulosa Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.88 AFP DICER1 FOXL2 PTH1R SMARCA4 WT1
2 homeostasis/metabolism MP:0005376 9.85 AFP DICER1 FOXL2 PTH1R SMARCA4 WT1
3 embryo MP:0005380 9.73 DICER1 PTH1R SMARCA4 WT1
4 mortality/aging MP:0010768 9.73 AFP DICER1 FOXL2 PTH1R SMARCA4 WT1
5 liver/biliary system MP:0005370 9.72 AFP DICER1 PTH1R SMARCA4 WT1
6 neoplasm MP:0002006 9.55 AFP DICER1 PTH1R SMARCA4 WT1
7 respiratory system MP:0005388 9.26 DICER1 PTH1R SMARCA4 WT1
8 vision/eye MP:0005391 8.92 DICER1 FOXL2 PTH1R SMARCA4

Drugs & Therapeutics for Juvenile Type Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Juvenile Type Testicular Granulosa Cell Tumor

Genetic Tests for Juvenile Type Testicular Granulosa Cell Tumor

Anatomical Context for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Juvenile Type Testicular Granulosa Cell Tumor:

41
Ovary, Testis, Bone, Lymph Node, Smooth Muscle, Bone Marrow, Kidney

Publications for Juvenile Type Testicular Granulosa Cell Tumor

Articles related to Juvenile Type Testicular Granulosa Cell Tumor:

(show top 50) (show all 108)
# Title Authors Year
1
Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature. ( 30547828 )
2018
2
Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review. ( 30011982 )
2018
3
A rare case report of ovarian juvenile granulosa cell tumor with massive ascites as the first sign, and review of literature: Case report and review of literature. ( 29923976 )
2018
4
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. ( 27702598 )
2017
5
The association of enchondromatosis with malignant transformed chondrosarcoma and ovarian juvenile granulosa cell tumor (Ollier disease). ( 28420520 )
2017
6
Juvenile Granulosa Cell Tumor of the Testicle - Report of a Neonatal Case with Positive Alpha-fetoprotein Immunohistochemical Staining. ( 28331810 )
2017
7
Juvenile granulosa cell tumor associated with Ollier disease. ( 28144098 )
2016
8
Juvenile granulosa cell tumor of the testis in a newborn. ( 27569101 )
2016
9
Long-term survival in a patient with an advanced ovarian juvenile granulosa cell tumor with para-aortic lymph node metastasis. ( 28040149 )
2016
10
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
11
Long-term Remission in a Female With Multiple Relapsed Juvenile Granulosa Cell Tumor. ( 26165406 )
2015
12
Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. ( 26169919 )
2015
13
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. ( 24656706 )
2014
14
Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. ( 25165122 )
2014
15
Juvenile granulosa cell tumor of the testis: a bilateral and synchronous case. Should testis-sparing surgery be mandatory? ( 25053523 )
2014
16
Juvenile granulosa cell tumor of the testis. ( 25148497 )
2014
17
Ovarian juvenile granulosa cell tumor in a 20-month-old infant. ( 25266542 )
2014
18
Paraneoplastic hypercalcemia associated with juvenile granulosa cell tumor. ( 23519754 )
2013
19
Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature. ( 23776871 )
2013
20
Hypercalcemia in a child with juvenile granulosa cell tumor of ovary: Report of an unusual paraneoplastic syndrome and review of the literature. ( 24371683 )
2013
21
Juvenile granulosa cell tumor with an unusual immunoprofile, presenting as precocious puberty. ( 24455600 )
2013
22
Massive ascites as the only sign of ovarian juvenile granulosa cell tumor in an adolescent: a case report and a review of the literature. ( 23424695 )
2013
23
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. ( 22353374 )
2012
24
Juvenile granulosa cell tumor arising from intra-abdominal testis in newborn: case report and review of the literature. ( 22088573 )
2012
25
A rare case of ovarian juvenile granulosa cell tumor without precocious pseudopuberty in an 11-month-old infant. ( 22244428 )
2012
26
Juvenile granulosa cell tumor of the testis: prenatal diagnosis and prescrotal approach. ( 23217189 )
2012
27
Childhood ovarian juvenile granulosa cell tumor: a retrospective study with 3 cases including clinical features, pathologic results, and therapies. ( 21358338 )
2011
28
Early pregnancy complicated with juvenile granulosa cell tumor. ( 21841464 )
2011
29
Re: congenital juvenile granulosa cell tumor of the testis in newborns. ( 22088653 )
2011
30
A rare neonatal testicular tumor: juvenile granulosa cell tumor of infant testis: a report of 3 cases. ( 20445412 )
2010
31
Congenital juvenile granulosa cell tumor of the testis in newborns. ( 20592370 )
2010
32
[Juvenile granulosa-cell tumor: clinical and molecular expression]. ( 19119048 )
2009
33
An Unusual Case of Juvenile Granulosa Cell Tumor of the Ovary. ( 27843515 )
2009
34
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. ( 19225930 )
2009
35
First case of juvenile granulosa cell tumor in an adult with Ollier disease. ( 19696617 )
2009
36
Three-month-old boy with juvenile granulosa cell tumor of testis and ossifying renal tumor of infancy. ( 19573898 )
2009
37
Juvenile granulosa cell tumor of the ovary associated with hypercalcemia. ( 17849133 )
2008
38
Aberrant expression of ovary determining gene FOXL2 in the testis and juvenile granulosa cell tumor in children. ( 18721930 )
2008
39
Recurrent juvenile granulosa cell tumor of the ovary managed by palliative radiotherapy. ( 18028383 )
2008
40
Juvenile granulosa cell tumor of adult testis: a case report. ( 18313118 )
2008
41
Juvenile granulosa cell tumor of testis: case report and review of literature. ( 18548396 )
2008
42
Prenatal diagnosis of juvenile granulosa cell tumor of the testis. ( 18760677 )
2008
43
Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report. ( 17624097 )
2007
44
Testicular juvenile granulosa cell tumor: a case report. ( 17718142 )
2007
45
Juvenile granulosa cell tumor of the epididymis. ( 17406141 )
2007
46
Testicular juvenile granulosa cell tumor in a newborn: case report and review of the literature. ( 17652550 )
2007
47
MRI findings of bilateral juvenile granulosa cell tumor of the testis in a newborn presenting as intraabdominal masses. ( 17661024 )
2007
48
Unusual presentation of juvenile granulosa cell tumor of the ovary. ( 16957416 )
2006
49
Juvenile granulosa cell tumor of the ovary associated with tuberous sclerosis. ( 16516278 )
2006
50
Juvenile granulosa cell tumor associated with pregnancy: Report of a case and review of the literature. ( 16256182 )
2006

Variations for Juvenile Type Testicular Granulosa Cell Tumor

Expression for Juvenile Type Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Juvenile Type Testicular Granulosa Cell Tumor.

Pathways for Juvenile Type Testicular Granulosa Cell Tumor

Pathways related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.28 AFP SMARCA4
2 10.92 AFP SMARCA4 WT1
3 10.87 AFP SMARCA4

GO Terms for Juvenile Type Testicular Granulosa Cell Tumor

Biological processes related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.5 FOXL2 SMARCA4 WT1
2 negative regulation of transcription, DNA-templated GO:0045892 9.43 FOXL2 SMARCA4 WT1
3 negative regulation of cell growth GO:0030308 9.37 SMARCA4 WT1
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.26 DICER1 FOXL2 SMARCA4 WT1
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.16 SMARCA4 WT1
6 apoptotic DNA fragmentation GO:0006309 8.62 DICER1 FOXL2

Sources for Juvenile Type Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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