MCID: JVN002
MIFTS: 28

Juvenile Type Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Reproductive diseases, Endocrine diseases

Aliases & Classifications for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Juvenile Type Testicular Granulosa Cell Tumor:

Name: Juvenile Type Testicular Granulosa Cell Tumor 12 15 73
Juvenile Granulosa Cell Tumor 12 73
Juvenile Type Granulosa Cell Neoplasm 12
Juvenile Type Granulosa Cell Tumor 12
Juvenile Granulosa Cell Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6032
NCIt 50 C39947
SNOMED-CT 68 189735004 77029009

Summaries for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards based summary : Juvenile Type Testicular Granulosa Cell Tumor, also known as juvenile granulosa cell tumor, is related to gynandroblastoma and maligant granulosa cell tumor of the ovary. An important gene associated with Juvenile Type Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary and testis, and related phenotype is liver/biliary system.

Related Diseases for Juvenile Type Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Juvenile Type Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 31.3 DICER1 FOXL2
2 maligant granulosa cell tumor of the ovary 10.8 DICER1 FOXL2
3 corpus luteum cyst 10.8 AFP FOXL2
4 ovarian cyst 10.7 AFP FOXL2
5 ovarian small cell carcinoma 10.6 SMARCA4 WT1
6 tumor predisposition syndrome 10.6 DICER1 SMARCA4
7 granulosa cell tumor of the ovary 10.6
8 kidney sarcoma 10.6 DICER1 WT1
9 adenomatoid tumor 10.6 AFP WT1
10 cystic nephroma 10.6 DICER1 WT1
11 nephrotic syndrome, type 1 10.5 AFP WT1
12 pineoblastoma 10.5 AFP DICER1
13 testicular trophoblastic tumor 10.5 CSH1 CSH2
14 kidney rhabdoid cancer 10.5 CD99 WT1
15 choriocarcinoma of ovary 10.5 CSH1 CSH2
16 mucinous cystadenofibroma 10.5 AFP CEACAM5
17 reproductive organ benign neoplasm 10.5 AFP DICER1
18 urachal adenocarcinoma 10.5 AFP CEACAM5
19 liver lymphoma 10.5 AFP CEACAM5
20 melanotic medulloblastoma 10.5 AFP CEACAM5
21 non-gestational choriocarcinoma 10.4 CSH1 CSH2
22 hematocele of tunica vaginalis testis 10.4 AFP CEACAM5
23 bile duct cystadenocarcinoma 10.4 AFP CEACAM5
24 liver sarcoma 10.4 AFP CEACAM5
25 rete testis adenocarcinoma 10.4 AFP CEACAM5
26 gestational trophoblastic neoplasm 10.4 CSH1 CSH2
27 gonadoblastoma 10.4 FOXL2 WT1
28 rete testis neoplasm 10.3 AFP CEACAM5
29 pancreatic cystadenocarcinoma 10.3 AFP CEACAM5
30 extragonadal seminoma 10.3 AFP CEACAM5
31 bone ewing's sarcoma 10.3 CD99 WT1
32 epidermolysis bullosa, junctional, herlitz type 10.3 AFP CEACAM5
33 sertoli-leydig cell tumor 10.3 AFP DICER1 WT1
34 breast adenomyoepithelioma 10.3 CD99 CEACAM5
35 dysgerminoma of ovary 10.3 AFP DICER1 WT1
36 chronic salpingitis 10.2 CSH1 CSH2
37 breast myoepithelial neoplasm 10.2 CD99 CEACAM5
38 ovarian mucinous neoplasm 10.2 CEACAM5 WT1
39 female reproductive system disease 10.2 CSH1 CSH2 FOXL2
40 choriocarcinoma of the testis 10.2 AFP CSH1 CSH2
41 rh isoimmunization 10.2 AFP CSH1 CSH2
42 germ cell and embryonal cancer 10.1 AFP CSH1 CSH2
43 uterine anomalies 10.1 AFP CSH1 CSH2
44 placenta disease 10.1 AFP CSH1 CSH2
45 bile duct adenocarcinoma 10.1 AFP CEACAM5
46 ovarian melanoma 10.1 MLANA SMARCA4
47 enchondromatosis, multiple, ollier type 10.1
48 malignant biphasic mesothelioma 10.0 AFP CEACAM5 WT1
49 precocious puberty 10.0
50 ovarian cancer 1 10.0 CEACAM5 WT1

Graphical network of the top 20 diseases related to Juvenile Type Testicular Granulosa Cell Tumor:



Diseases related to Juvenile Type Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Juvenile Type Testicular Granulosa Cell Tumor

MGI Mouse Phenotypes related to Juvenile Type Testicular Granulosa Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.02 AFP DICER1 IGFBP2 SMARCA4 WT1

Drugs & Therapeutics for Juvenile Type Testicular Granulosa Cell Tumor

Search Clinical Trials , NIH Clinical Center for Juvenile Type Testicular Granulosa Cell Tumor

Genetic Tests for Juvenile Type Testicular Granulosa Cell Tumor

Anatomical Context for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Juvenile Type Testicular Granulosa Cell Tumor:

41
Ovary, Testis

Publications for Juvenile Type Testicular Granulosa Cell Tumor

Articles related to Juvenile Type Testicular Granulosa Cell Tumor:

(show top 50) (show all 53)
# Title Authors Year
1
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. ( 27702598 )
2017
2
The association of enchondromatosis with malignant transformed chondrosarcoma and ovarian juvenile granulosa cell tumor (Ollier disease). ( 28420520 )
2017
3
Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads. ( 26362254 )
2015
4
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
5
Long-term Remission in a Female With Multiple Relapsed Juvenile Granulosa Cell Tumor. ( 26165406 )
2015
6
Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. ( 26169919 )
2015
7
A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors. ( 26137586 )
2015
8
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. ( 24656706 )
2014
9
Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. ( 25165122 )
2014
10
Paraneoplastic hypercalcemia associated with juvenile granulosa cell tumor. ( 23519754 )
2013
11
Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature. ( 23776871 )
2013
12
Hypercalcemia in a child with juvenile granulosa cell tumor of ovary: Report of an unusual paraneoplastic syndrome and review of the literature. ( 24371683 )
2013
13
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. ( 22353374 )
2012
14
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary. ( 21623383 )
2011
15
Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency. ( 20395670 )
2010
16
[Juvenile granulosa-cell tumor: clinical and molecular expression]. ( 19119048 )
2009
17
An Unusual Case of Juvenile Granulosa Cell Tumor of the Ovary. ( 27843515 )
2009
18
No activating mutations of FSH receptor in four children with ovarian juvenile granulosa cell tumors and the association of these tumors with central precocious puberty. ( 19539204 )
2009
19
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. ( 19225930 )
2009
20
First case of juvenile granulosa cell tumor in an adult with Ollier disease. ( 19696617 )
2009
21
Juvenile granulosa cell tumor of the ovary associated with hypercalcemia. ( 17849133 )
2008
22
Aberrant expression of ovary determining gene FOXL2 in the testis and juvenile granulosa cell tumor in children. ( 18721930 )
2008
23
Recurrent juvenile granulosa cell tumor of the ovary managed by palliative radiotherapy. ( 18028383 )
2008
24
Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report. ( 17624097 )
2007
25
Testicular juvenile granulosa cell tumor: a case report. ( 17718142 )
2007
26
Unusual presentation of juvenile granulosa cell tumor of the ovary. ( 16957416 )
2006
27
Juvenile granulosa cell tumor of the ovary associated with tuberous sclerosis. ( 16516278 )
2006
28
Juvenile granulosa cell tumor of the ovary in an elderly woman. ( 16167924 )
2005
29
Congenital juvenile granulosa cell tumor of the testis in a fetus showing full 69,XXY triploidy. ( 15864389 )
2005
30
Late recurrence of juvenile granulosa cell tumor of the ovary. ( 15295395 )
2004
31
Juvenile granulosa cell tumor of the testis:: contemporary clinical management and pathological diagnosis. ( 15076304 )
2004
32
Juvenile granulosa cell tumor of the ovary: imprint cytology findings. ( 12462106 )
2002
33
Clinical analysis of 4 cases of juvenile granulosa cell tumor of the ovary. ( 12411036 )
2002
34
Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary. ( 11990313 )
2002
35
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. ( 11531301 )
2001
36
Management of recurrent juvenile granulosa cell tumor of the ovary. ( 11277661 )
2001
37
Severe hypercalcemia in association with a juvenile granulosa cell tumor of the ovary. ( 10742079 )
2000
38
Trisomy 12 in juvenile granulosa cell tumor of the ovary during pregnancy. A report of two cases. ( 10509309 )
1999
39
Gynandroblastoma with elements of juvenile granulosa cell tumor. ( 9553819 )
1998
40
Gynandroblastoma with elements resembling juvenile granulosa cell tumor. ( 9421080 )
1997
41
Management of advanced juvenile granulosa cell tumor of the ovary. ( 9038278 )
1997
42
Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature. ( 9165474 )
1997
43
Juvenile granulosa cell tumor discovered during pregnancy: case report with immunohistochemical study of steroidogenesis. ( 9143029 )
1997
44
Juvenile granulosa-cell tumor of the ovary - interphase cytogenetics for chromosome-12 and chromosome-x and flow cytometric DNA-ploidy study. ( 21552888 )
1995
45
Testicular juvenile granulosa cell tumor in an infant with X/XY mosaicism clinically diagnosed as true hermaphroditism. ( 8116801 )
1994
46
Management of advanced juvenile granulosa cell tumor of the ovary. ( 8423014 )
1993
47
Congenital bilateral juvenile granulosa cell tumor of the ovary in leprechaunism: a case report. ( 8247952 )
1993
48
Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases. ( 3373268 )
1988
49
Cystic juvenile granulosa cell tumor of the ovary. ( 3176932 )
1988
50
Ollier disease (enchondromatosis) associated with ovarian juvenile granulosa cell tumor and precocious pseudopuberty. ( 3712163 )
1986

Variations for Juvenile Type Testicular Granulosa Cell Tumor

Expression for Juvenile Type Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Juvenile Type Testicular Granulosa Cell Tumor.

Pathways for Juvenile Type Testicular Granulosa Cell Tumor

Pathways related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 AFP SMARCA4 WT1

GO Terms for Juvenile Type Testicular Granulosa Cell Tumor

Biological processes related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic DNA fragmentation GO:0006309 8.62 DICER1 FOXL2

Sources for Juvenile Type Testicular Granulosa Cell Tumor

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10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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