MCID: JVN002
MIFTS: 34

Juvenile Type Testicular Granulosa Cell Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards integrated aliases for Juvenile Type Testicular Granulosa Cell Tumor:

Name: Juvenile Type Testicular Granulosa Cell Tumor 12 15 70
Juvenile Granulosa Cell Tumor 12 70
Juvenile Type Testicular Granulosa Cell Tumour 12
Juvenile Type Granulosa Cell Neoplasm 12
Juvenile Type Granulosa Cell Tumour 12
Juvenile Type Granulosa Cell Tumor 12
Juvenile Granulosa Cell Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6032
NCIt 50 C39947 C4207
SNOMED-CT 67 189735004
UMLS 70 C0334403 C1515285

Summaries for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards based summary : Juvenile Type Testicular Granulosa Cell Tumor, also known as juvenile granulosa cell tumor, is related to gynandroblastoma and mixed gonadal dysgenesis. An important gene associated with Juvenile Type Testicular Granulosa Cell Tumor is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and BRCA1 Pathway. Affiliated tissues include ovary, testis and bone marrow, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Related Diseases for Juvenile Type Testicular Granulosa Cell Tumor

Diseases in the Testicular Granulosa Cell Tumor family:

Juvenile Type Testicular Granulosa Cell Tumor Adult Type Testicular Granulosa Cell Tumor

Diseases related to Juvenile Type Testicular Granulosa Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 30.9 FOXL2 DICER1 CALB2
2 mixed gonadal dysgenesis 30.4 MIR302C FOXL2
3 cystic lymphangioma 30.4 CALB2 AFP
4 leydig cell tumor 30.3 GNAS CALB2 AFP
5 sertoli-leydig cell tumor 30.2 WT1 MIR302C DICER1 CALB2 AFP
6 sertoli cell tumor 30.2 WT1 CALB2 AFP
7 teratoma 29.9 SMARCB1 CD99 CALB2 AFP
8 ovarian cyst 29.9 GNAS FOXL2 AFP
9 cystadenoma 29.8 GNAS CALB2 AFP
10 ovarian sex-cord stromal tumor 29.7 WT1 FOXL2 DICER1 CD99 CALB2
11 granulosa cell tumor of the ovary 10.8
12 precocious puberty 10.5
13 rare tumor 10.5
14 enchondromatosis, multiple, ollier type 10.4
15 maligant granulosa cell tumor of the ovary 10.3 FOXL2 DICER1
16 luteoma 10.3 FOXL2 CALB2
17 corpus luteum cyst 10.3 FOXL2 AFP
18 amenorrhea 10.3
19 gonadoblastoma 10.3 WT1 FOXL2
20 rete testis neoplasm 10.3 CALB2 AFP
21 rete testis adenocarcinoma 10.3 CALB2 AFP
22 bladder leiomyoma 10.3 DICER1 CALB2
23 dermoid cyst of ovary 10.3 CALB2 AFP
24 spermatocele 10.3 CALB2 AFP
25 infected hydrocele 10.3 CALB2 AFP
26 hydrocele 10.3 CALB2 AFP
27 non-gestational choriocarcinoma 10.3 MIR302C AFP
28 botryoid rhabdomyosarcoma 10.3 DICER1 AFP
29 common bile duct disease 10.3 MIR302C AFP
30 fallopian tube carcinosarcoma 10.2 WT1 CALB2
31 pediatric germ cell cancer 10.2 MIR302C AFP
32 wolffian duct adenocarcinoma 10.2 WT1 CALB2
33 pericardium cancer 10.2 WT1 CALB2
34 malignant biphasic mesothelioma 10.2 WT1 CALB2
35 cystadenofibroma 10.2 WT1 CALB2
36 ovarian endometrioid stromal sarcoma 10.2 WT1 CALB2
37 endosalpingiosis 10.2 WT1 CALB2
38 kidney sarcoma 10.2 WT1 DICER1
39 peritoneal serous adenocarcinoma 10.2 WT1 CALB2
40 ovarian mixed germ cell neoplasm 10.2 WT1 AFP
41 testicular torsion 10.2
42 chondrosarcoma 10.2
43 multiple enchondromatosis, maffucci type 10.2
44 gonadal dysgenesis 10.2
45 endodermal sinus tumor 10.2
46 hemangioma 10.2
47 chondroma 10.2
48 hermaphroditism 10.2
49 testicular yolk sac tumor 10.2
50 enchondroma 10.2

Graphical network of the top 20 diseases related to Juvenile Type Testicular Granulosa Cell Tumor:



Diseases related to Juvenile Type Testicular Granulosa Cell Tumor

Symptoms & Phenotypes for Juvenile Type Testicular Granulosa Cell Tumor

MGI Mouse Phenotypes related to Juvenile Type Testicular Granulosa Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.92 AFP BMPR1B DICER1 FOXL2 GNAS SMARCA2
2 liver/biliary system MP:0005370 9.73 AFP DICER1 GNAS SMARCA4 SMARCB1 WT1
3 muscle MP:0005369 9.63 DICER1 GNAS SMARCA2 SMARCA4 SMARCB1 WT1
4 neoplasm MP:0002006 9.5 AFP DICER1 GNAS SMARCA2 SMARCA4 SMARCB1
5 normal MP:0002873 9.17 BMPR1B CALB2 DICER1 FOXL2 GNAS SMARCA4

Drugs & Therapeutics for Juvenile Type Testicular Granulosa Cell Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Juvenile Type Testicular Granulosa Cell Tumor

Genetic Tests for Juvenile Type Testicular Granulosa Cell Tumor

Anatomical Context for Juvenile Type Testicular Granulosa Cell Tumor

MalaCards organs/tissues related to Juvenile Type Testicular Granulosa Cell Tumor:

40
Ovary, Testis, Bone Marrow, Lymph Node, Smooth Muscle, Testes, Pituitary

Publications for Juvenile Type Testicular Granulosa Cell Tumor

Articles related to Juvenile Type Testicular Granulosa Cell Tumor:

(show top 50) (show all 209)
# Title Authors PMID Year
1
Case of fetal ovarian juvenile granulosa cell tumor: Complications and management. 61
33754426 2021
2
Extraovarian juvenile granulosa cell tumor in a prepubertal child: novel location of a rare tumor. 61
33621150 2021
3
[Juvenile granulosa cell tumor-Testicular tumor of the very young : Report of three cases and contemporary recommendations]. 61
33201299 2021
4
Metachronous Contralateral Cystadenoma After Ovariectomy for Juvenile Granulosa Cell Tumor in a Young Girl: An Uncommon Association. 61
32745618 2021
5
Juvenile granulosa cell tumor of the ovary: A comprehensive clinicopathologic analysis of 15 cases. 61
33725665 2021
6
Sertoli-Leydig Cell Tumors of the Ovary With Follicular Differentiation Often Resembling Juvenile Granulosa Cell Tumor: A Report of 38 Cases Including Comments on Sex Cord-Stromal Tumors of Mixed Forms (So-called Gynandroblastoma). 61
32815828 2021
7
An Unusual Cause of Secondary Amenorrhea in an Adolescent: Expanding the Differential. 61
33241170 2020
8
Hyperreactio Luteinalis (Multiple Luteinized Follicle Cysts): A Report of 10 Cases. 61
33323862 2020
9
Malignant Sex Cord-Stromal Tumor, Not Otherwise Specified, Harboring FOXL2, p53, and TERT Promoter Mutations: Report of a Case. 61
31789679 2020
10
Gender Dysphoria Disrupting the Course of Treatment of a Recurrent Juvenile Granulosa Cell Tumor in an Adolescent Female: A Case Report. 61
33362514 2020
11
Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman. 61
32751726 2020
12
[Juvenile granulosa cell tumor in children: a clinicopathological analysis of eight cases]. 61
32610388 2020
13
[Neonatal juvenile granulosa cell tumor, a rare entity]. 61
32616398 2020
14
Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature. 61
32144835 2020
15
Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case. 61
32341591 2020
16
Multiple Luteinized Follicle Cysts of the Ovary in a Patient With a Pituitary Adenoma: Report of a Case and Review of the Literature. 61
30358638 2019
17
Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty. 61
31582893 2019
18
Adult Granulosa Cell Tumor With High-grade Transformation: Report of a Series With FOXL2 Mutation Analysis. 61
31162286 2019
19
Juvenile granulosa cell tumor associated with Maffucci syndrome in pregnancy: A case report. 61
30965205 2019
20
A Rare Case of Uterine Torsion With Juvenile Granulosa Cell Tumor in the Pediatric Patient. 61
30796991 2019
21
Outcomes of fertility-sparing surgery in ovarian juvenile granulosa cell tumor. 61
30728165 2019
22
Juvenile Granulosa Cell Tumor of the Testis: Prenatal Diagnosis and Management. 61
31871849 2019
23
Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature. 61
30547828 2018
24
Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD. 61
30500284 2018
25
Multimodal molecular analysis of an atypical small cell carcinoma of the ovary, hypercalcemic type. 61
30275002 2018
26
Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review. 61
30011982 2018
27
Granulosa-cell tumor after ovarian stimulation: A case report. 61
30123871 2018
28
A rare case report of ovarian juvenile granulosa cell tumor with massive ascites as the first sign, and review of literature: Case report and review of literature. 61
29923976 2018
29
The molecular mechanism of ovarian granulosa cell tumors. 61
29409506 2018
30
Juvenile Granulosa Cell Tumor of the Testicle - Report of a Neonatal Case with Positive Alpha-fetoprotein Immunohistochemical Staining. 61
28331810 2017
31
The association of enchondromatosis with malignant transformed chondrosarcoma and ovarian juvenile granulosa cell tumor (Ollier disease). 61
28420520 2017
32
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. 61
27702598 2017
33
Long-term survival in a patient with an advanced ovarian juvenile granulosa cell tumor with para-aortic lymph node metastasis. 61
28040149 2016
34
Spontaneous regression of suspected cystic dysplasia of the rete testis in three neonates. 61
27372158 2016
35
Juvenile granulosa cell tumor associated with Ollier disease. 61
28144098 2016
36
Juvenile granulosa cell tumor of the testis in a newborn. 61
27569101 2016
37
[Recurrence occurring ten years after the initial diagnosis of granulosa cell tumour of the ovary: about two cases and review of the literatur]. 61
28154722 2016
38
[Peripheral precocious puberty]. 61
27897024 2016
39
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric ovarian tumors: a novel treatment approach. 61
26500075 2016
40
Long-term Remission in a Female With Multiple Relapsed Juvenile Granulosa Cell Tumor. 61
26165406 2015
41
SMARCA4-deficient undifferentiated carcinoma of the ovary (small cell carcinoma, hypercalcemic type): clinicopathologic and immunohistochemical study of 3 cases. 61
26123103 2015
42
Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. 61
26169919 2015
43
Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases. 61
25828390 2015
44
Ovarian sex cord-stromal tumors in patients with probable or confirmed germline DICER1 mutations. 61
25844550 2015
45
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. 61
25656930 2015
46
Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. 61
25165122 2014
47
Juvenile granulosa cell tumor of the testis. 61
25148497 2014
48
Juvenile granulosa cell tumor of the testis: a bilateral and synchronous case. Should testis-sparing surgery be mandatory? 61
25053523 2014
49
Ovarian tumors and tumor-like lesions in the first three decades. 61
25440719 2014
50
Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades. 61
25440720 2014

Variations for Juvenile Type Testicular Granulosa Cell Tumor

Expression for Juvenile Type Testicular Granulosa Cell Tumor

Search GEO for disease gene expression data for Juvenile Type Testicular Granulosa Cell Tumor.

Pathways for Juvenile Type Testicular Granulosa Cell Tumor

Pathways related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 WT1 SMARCA4 AFP
2
Show member pathways
11.25 SMARCB1 SMARCA4 SMARCA2
3
Show member pathways
11.16 SMARCB1 SMARCA4 SMARCA2 GNAS
4
Show member pathways
10.98 SMARCB1 SMARCA4 SMARCA2

GO Terms for Juvenile Type Testicular Granulosa Cell Tumor

Cellular components related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.56 GNAS DICER1 CALB2 BMPR1B
2 SWI/SNF complex GO:0016514 9.33 SMARCB1 SMARCA4 SMARCA2
3 nBAF complex GO:0071565 9.13 SMARCB1 SMARCA4 SMARCA2
4 npBAF complex GO:0071564 8.8 SMARCB1 SMARCA4 SMARCA2

Biological processes related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell growth GO:0030308 9.61 WT1 SMARCA4 SMARCA2
2 chromatin remodeling GO:0006338 9.5 SMARCB1 SMARCA4 SMARCA2
3 nucleosome disassembly GO:0006337 9.46 SMARCB1 SMARCA4
4 positive regulation by host of viral transcription GO:0043923 9.4 SMARCB1 SMARCA4
5 apoptotic DNA fragmentation GO:0006309 9.37 FOXL2 DICER1
6 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.26 SMARCB1 SMARCA4
7 RNA polymerase I preinitiation complex assembly GO:0001188 9.16 SMARCB1 SMARCA4
8 positive regulation of glucose mediated signaling pathway GO:1902661 8.96 SMARCB1 SMARCA4
9 ATP-dependent chromatin remodeling GO:0043044 8.8 SMARCB1 SMARCA4 SMARCA2

Molecular functions related to Juvenile Type Testicular Granulosa Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 helicase activity GO:0004386 9.43 SMARCA4 SMARCA2 DICER1
2 Tat protein binding GO:0030957 9.16 SMARCB1 SMARCA4
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.96 SMARCA4 SMARCA2
4 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 8.62 SMARCB1 SMARCA4

Sources for Juvenile Type Testicular Granulosa Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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