Aliases & Classifications for Juxtacortical Chondroma

MalaCards integrated aliases for Juxtacortical Chondroma:

Name: Juxtacortical Chondroma 12 15 73
Periosteal Chondroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2601
NCIt 50 C4302
SNOMED-CT 68 9266000
UMLS 73 C0334548

Summaries for Juxtacortical Chondroma

MalaCards based summary : Juxtacortical Chondroma, also known as periosteal chondroma, is related to chondroma and multiple enchondromatosis, maffucci type, and has symptoms including pain An important gene associated with Juxtacortical Chondroma is MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Mesodermal Commitment Pathway. Affiliated tissues include bone and cortex, and related phenotypes are digestive/alimentary and craniofacial

Related Diseases for Juxtacortical Chondroma

Diseases related to Juxtacortical Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 chondroma 30.8 CTNNB1 HMGA2 PTH1R
2 multiple enchondromatosis, maffucci type 10.6 EXT1 PTH1R
3 periostitis 10.3
4 atypical lipomatous tumor 10.3 FUS HMGA2
5 kidney fibrosarcoma 10.3 EWSR1 HMGA2
6 clear cell chondrosarcoma 10.3 PTH1R PTHLH
7 tooth ankylosis 10.3 PTH1R PTHLH
8 lipomatosis, multiple 10.3 FUS HMGA2
9 hypercalcemia, infantile, 1 10.2 PTH1R PTHLH
10 extraosseous chondrosarcoma 10.2 EWSR1 FUS
11 pyle disease 10.2 PTH1R PTHLH
12 chondroblastoma 10.2 PTH1R PTHLH
13 pseudohypoparathyroidism, type ib 10.2 PTH1R PTHLH
14 extraskeletal ewing sarcoma 10.2 EWSR1 FUS
15 metaphyseal chondrodysplasia, jansen type 10.2 PTH1R PTHLH
16 angiomyoma 10.1 HMGA2 PTHLH
17 chondromyxoid fibroma 10.1 PTH1R PTHLH
18 ideomotor apraxia 10.1 EWSR1 FUS
19 gastrointestinal system benign neoplasm 10.1 CTNNB1 HMGA2
20 osteochondroma 10.0 EXT1 PTHLH
21 clear cell adenoma 10.0 CTNNB1 PTHLH
22 skeletal dysplasias 10.0 PTH1R PTHLH
23 chondrosarcoma, extraskeletal myxoid 10.0 EWSR1 FUS
24 pseudohypoparathyroidism 10.0 PTH1R PTHLH
25 atypical teratoid rhabdoid tumor 9.9 CTNNB1 HMGA2
26 enchondromatosis, multiple, ollier type 9.9 EXT1 PTH1R PTHLH
27 connective tissue cancer 9.8 EWSR1 EXT1 FUS
28 bone disease 9.8 EXT1 PTH1R PTHLH
29 clear cell sarcoma 9.8 EWSR1 FUS
30 myxoid liposarcoma 9.8 EWSR1 FUS HMGA2
31 liposarcoma 9.8 EWSR1 FUS HMGA2
32 soft tissue sarcoma 9.7 EWSR1 TERT
33 fibrous histiocytoma 9.7 EWSR1 FUS
34 cystitis cystica 9.6 CTNNB1 TERT
35 periosteal chondrosarcoma 9.6 CTNNB1 EXT1 PTHLH
36 chondrosarcoma 9.6 EWSR1 EXT1 PTHLH
37 cell type benign neoplasm 9.5 CTNNB1 HMGA2

Graphical network of the top 20 diseases related to Juxtacortical Chondroma:



Diseases related to Juxtacortical Chondroma

Symptoms & Phenotypes for Juxtacortical Chondroma

UMLS symptoms related to Juxtacortical Chondroma:


pain

MGI Mouse Phenotypes related to Juxtacortical Chondroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.85 PTH1R PTHLH CTNNB1 EXT1 TERT MIB1
2 craniofacial MP:0005382 9.8 MIB1 PTH1R PTHLH CTNNB1 EXT1
3 endocrine/exocrine gland MP:0005379 9.8 MIB1 PTH1R PTHLH CTNNB1 RBP1 TERT
4 growth/size/body region MP:0005378 9.8 MIB1 PTH1R PTHLH CTNNB1 RBP1 EXT1
5 limbs/digits/tail MP:0005371 9.55 MIB1 PTH1R PTHLH CTNNB1 EXT1
6 nervous system MP:0003631 9.5 MIB1 PTH1R PTHLH CTNNB1 RBP1 EXT1
7 skeleton MP:0005390 9.1 MIB1 PTH1R PTHLH CTNNB1 TERT EXT1

Drugs & Therapeutics for Juxtacortical Chondroma

Search Clinical Trials , NIH Clinical Center for Juxtacortical Chondroma

Genetic Tests for Juxtacortical Chondroma

Anatomical Context for Juxtacortical Chondroma

MalaCards organs/tissues related to Juxtacortical Chondroma:

41
Bone, Cortex

Publications for Juxtacortical Chondroma

Articles related to Juxtacortical Chondroma:

(show all 12)
# Title Authors Year
1
Imaging features of juxtacortical chondroma in children. ( 23955368 )
2014
2
Juxtacortical chondroma of the sacrum. ( 18843465 )
2008
3
First occurrence of periosteal chondroma (juxtacortical chondroma) in Uromastyxmaliensis (Reptilia: Sauria: Agamidae). ( 17867460 )
2007
4
Juxtacortical chondroma of the hand: treatment by resection of the tumour and the adjacent bone cortex. ( 15935532 )
2005
5
Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. ( 7785598 )
1995
6
Phalangeal periosteal (juxtacortical)chondroma of the foot. ( 1430837 )
1992
7
Case report 196: juxtacortical chondroma of C2. ( 6954647 )
1982
8
Juxtacortical chondroma of the hyoid bone. Report of a case. ( 6058416 )
1967
9
Juxtacortical chondroma. A case report. ( 5837642 )
1965
10
Periosteal chondroma (juxtacortical chondroma). ( 5889127 )
1964
11
Juxtacortical chondroma. ( 13499868 )
1958
12
Juxtacortical chondroma. ( 13374443 )
1956

Variations for Juxtacortical Chondroma

Expression for Juxtacortical Chondroma

Search GEO for disease gene expression data for Juxtacortical Chondroma.

Pathways for Juxtacortical Chondroma

Pathways related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 EWSR1 FUS HMGA2
2
Show member pathways
11.41 CTNNB1 EXT1 HMGA2 PTHLH
3 11.4 EWSR1 FUS HMGA2
4 10.75 PTH1R PTHLH

GO Terms for Juxtacortical Chondroma

Cellular components related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 8.62 CTNNB1 HMGA2

Biological processes related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 beta-catenin-TCF complex assembly GO:1904837 9.49 CTNNB1 TERT
2 chondrocyte differentiation GO:0002062 9.48 HMGA2 PTH1R
3 epithelial to mesenchymal transition GO:0001837 9.46 CTNNB1 HMGA2
4 cell maturation GO:0048469 9.43 CTNNB1 PTH1R
5 bone mineralization GO:0030282 9.4 PTH1R PTHLH
6 bone resorption GO:0045453 9.37 CTNNB1 PTH1R
7 negative regulation of cellular senescence GO:2000773 9.32 HMGA2 TERT
8 osteoblast development GO:0002076 9.26 PTH1R PTHLH
9 negative regulation of chondrocyte differentiation GO:0032331 9.16 CTNNB1 PTHLH
10 positive regulation of stem cell proliferation GO:2000648 8.96 HMGA2 TERT
11 skeletal system development GO:0001501 8.92 CTNNB1 EXT1 PTH1R PTHLH

Molecular functions related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 8.96 CTNNB1 HMGA2
2 estrogen receptor binding GO:0030331 8.62 CTNNB1 FUS

Sources for Juxtacortical Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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