MCID: JXT001
MIFTS: 31

Juxtacortical Chondroma

Categories: Cancer diseases

Aliases & Classifications for Juxtacortical Chondroma

MalaCards integrated aliases for Juxtacortical Chondroma:

Name: Juxtacortical Chondroma 12 15 73
Periosteal Chondroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2601
NCIt 50 C4302
SNOMED-CT 68 9266000
UMLS 73 C0334548

Summaries for Juxtacortical Chondroma

MalaCards based summary : Juxtacortical Chondroma, also known as periosteal chondroma, is related to chondroma and chondrosarcoma, and has symptoms including pain An important gene associated with Juxtacortical Chondroma is MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Mesodermal Commitment Pathway. Affiliated tissues include bone, cortex and kidney, and related phenotypes are digestive/alimentary and growth/size/body region

Related Diseases for Juxtacortical Chondroma

Diseases related to Juxtacortical Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 chondroma 31.0 CTNNB1 HMGA2 PTH1R
2 chondrosarcoma 30.3 EWSR1 EXT1 PTHLH
3 osteochondroma 30.3 EXT1 PTHLH
4 periosteal chondrosarcoma 30.2 EXT1 PTHLH
5 enchondroma 10.2
6 multiple enchondromatosis, maffucci type 10.2 EXT1 PTH1R
7 atypical lipomatous tumor 10.1 FUS HMGA2
8 sarcomatosis 10.1 EWSR1 HMGA2
9 tooth ankylosis 10.1 PTH1R PTHLH
10 clear cell chondrosarcoma 10.1 PTH1R PTHLH
11 kidney fibrosarcoma 10.1 EWSR1 HMGA2
12 lipomatosis, multiple 10.1 FUS HMGA2
13 cellular myxoid liposarcoma 10.1 EWSR1 FUS
14 hypercalcemia, infantile, 1 10.1 PTH1R PTHLH
15 extraosseous chondrosarcoma 10.1 EWSR1 FUS
16 chondroblastoma 10.1 PTH1R PTHLH
17 carpal tunnel syndrome 10.1
18 mononeuropathy of the median nerve, mild 10.1
19 secondary hyperparathyroidism of renal origin 10.1
20 hyperparathyroidism 10.1
21 hyperostosis 10.1
22 osgood-schlatter's disease 10.1
23 bizzare parosteal osteochondromatous proliferation 10.1
24 extraskeletal ewing sarcoma 10.0 EWSR1 FUS
25 metaphyseal chondrodysplasia, jansen type 10.0 PTH1R PTHLH
26 chondromyxoid fibroma 10.0 PTH1R PTHLH
27 angiomyoma 10.0 HMGA2 PTHLH
28 pseudohypoparathyroidism 10.0 PTH1R PTHLH
29 chondrosarcoma, extraskeletal myxoid 10.0 EWSR1 FUS
30 pseudohypoparathyroidism, type ib 10.0 PTH1R PTHLH
31 clear cell adenoma 10.0 CTNNB1 PTHLH
32 atypical teratoid rhabdoid tumor 10.0 CTNNB1 HMGA2
33 clear cell sarcoma 10.0 EWSR1 FUS
34 enchondromatosis, multiple, ollier type 10.0 EXT1 PTH1R PTHLH
35 fibrous histiocytoma 10.0 EWSR1 FUS
36 connective tissue cancer 9.9 EWSR1 EXT1 FUS
37 bone disease 9.9 EXT1 PTH1R PTHLH
38 histiocytoma 9.9 EWSR1 FUS
39 myxoid liposarcoma 9.9 EWSR1 FUS HMGA2
40 liposarcoma 9.9 EWSR1 FUS HMGA2
41 soft tissue sarcoma 9.9 EWSR1 TERT
42 cell type benign neoplasm 9.9 CTNNB1 HMGA2
43 cystitis cystica 9.9 CTNNB1 TERT
44 wilms tumor 1 9.7 CTNNB1 EWSR1 TERT
45 anaplastic thyroid cancer 9.7 CTNNB1 TERT

Graphical network of the top 20 diseases related to Juxtacortical Chondroma:



Diseases related to Juxtacortical Chondroma

Symptoms & Phenotypes for Juxtacortical Chondroma

UMLS symptoms related to Juxtacortical Chondroma:


pain

MGI Mouse Phenotypes related to Juxtacortical Chondroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 CTNNB1 EXT1 MIB1 PTH1R PTHLH TERT
2 growth/size/body region MP:0005378 9.91 CTNNB1 EXT1 MIB1 PTH1R PTHLH RBP1
3 endocrine/exocrine gland MP:0005379 9.88 CTNNB1 MIB1 PTH1R PTHLH RBP1 TERT
4 craniofacial MP:0005382 9.85 CTNNB1 EXT1 MIB1 PTH1R PTHLH
5 limbs/digits/tail MP:0005371 9.72 CTNNB1 EXT1 MIB1 PTH1R PTHLH
6 nervous system MP:0003631 9.7 CTNNB1 EXT1 MIB1 PTH1R PTHLH RBP1
7 neoplasm MP:0002006 9.65 CTNNB1 EXT1 PTH1R PTHLH TERT
8 skeleton MP:0005390 9.43 CTNNB1 EXT1 MIB1 PTH1R PTHLH TERT
9 vision/eye MP:0005391 9.02 CTNNB1 EXT1 PTH1R PTHLH RBP1

Drugs & Therapeutics for Juxtacortical Chondroma

Search Clinical Trials , NIH Clinical Center for Juxtacortical Chondroma

Genetic Tests for Juxtacortical Chondroma

Anatomical Context for Juxtacortical Chondroma

MalaCards organs/tissues related to Juxtacortical Chondroma:

41
Bone, Cortex, Kidney, Thyroid

Publications for Juxtacortical Chondroma

Articles related to Juxtacortical Chondroma:

(show all 16)
# Title Authors Year
1
A case of benign periosteal chondroma seeding into humeral medullary bone via percutaneous needle biopsy tract. ( 30363208 )
2015
2
Imaging features of juxtacortical chondroma in children. ( 23955368 )
2014
3
Periosteal chondroma of the ischium; an unusual location. ( 22627638 )
2012
4
Juxtacortical chondroma of the sacrum. ( 18843465 )
2008
5
Periosteal chondroma at birth. ( 18369616 )
2008
6
First occurrence of periosteal chondroma (juxtacortical chondroma) in Uromastyxmaliensis (Reptilia: Sauria: Agamidae). ( 17867460 )
2007
7
Juxtacortical chondroma of the hand: treatment by resection of the tumour and the adjacent bone cortex. ( 15935532 )
2005
8
Periosteal chondroma of the clavicle. ( 8738012 )
1996
9
Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. ( 7785598 )
1995
10
Phalangeal periosteal (juxtacortical)chondroma of the foot. ( 1430837 )
1992
11
Case report 196: juxtacortical chondroma of C2. ( 6954647 )
1982
12
Juxtacortical chondroma of the hyoid bone. Report of a case. ( 6058416 )
1967
13
Juxtacortical chondroma. A case report. ( 5837642 )
1965
14
Periosteal chondroma (juxtacortical chondroma). ( 5889127 )
1964
15
Juxtacortical chondroma. ( 13499868 )
1958
16
Juxtacortical chondroma. ( 13374443 )
1956

Variations for Juxtacortical Chondroma

Expression for Juxtacortical Chondroma

Search GEO for disease gene expression data for Juxtacortical Chondroma.

Pathways for Juxtacortical Chondroma

Pathways related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 EWSR1 FUS HMGA2
2
Show member pathways
11.41 CTNNB1 EXT1 HMGA2 PTHLH
3 11.4 EWSR1 FUS HMGA2
4 10.75 PTH1R PTHLH

GO Terms for Juxtacortical Chondroma

Cellular components related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 8.62 CTNNB1 HMGA2

Biological processes related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 bone mineralization GO:0030282 9.49 PTH1R PTHLH
2 chondrocyte differentiation GO:0002062 9.48 HMGA2 PTH1R
3 epithelial to mesenchymal transition GO:0001837 9.46 CTNNB1 HMGA2
4 cell maturation GO:0048469 9.43 CTNNB1 PTH1R
5 beta-catenin-TCF complex assembly GO:1904837 9.4 CTNNB1 TERT
6 bone resorption GO:0045453 9.37 CTNNB1 PTH1R
7 negative regulation of cellular senescence GO:2000773 9.32 HMGA2 TERT
8 osteoblast development GO:0002076 9.26 PTH1R PTHLH
9 negative regulation of chondrocyte differentiation GO:0032331 9.16 CTNNB1 PTHLH
10 positive regulation of stem cell proliferation GO:2000648 8.96 HMGA2 TERT
11 skeletal system development GO:0001501 8.92 CTNNB1 EXT1 PTH1R PTHLH

Molecular functions related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 8.96 CTNNB1 HMGA2
2 estrogen receptor binding GO:0030331 8.62 CTNNB1 FUS

Sources for Juxtacortical Chondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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