Juxtacortical Chondroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Juxtacortical Chondroma

MalaCards integrated aliases for Juxtacortical Chondroma:

Name: Juxtacortical Chondroma ¹² ¹⁵ ⁷³

Periosteal Chondroma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2601

NCIt ⁵⁰ C4302

SNOMED-CT ⁶⁸ 9266000

UMLS ⁷³ C0334548

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Summaries for Juxtacortical Chondroma

MalaCards based summary : Juxtacortical Chondroma, also known as periosteal chondroma, is related to chondroma and multiple enchondromatosis, maffucci type, and has symptoms including pain An important gene associated with Juxtacortical Chondroma is MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Mesodermal Commitment Pathway. Affiliated tissues include bone and cortex, and related phenotypes are digestive/alimentary and craniofacial

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Related Diseases for Juxtacortical Chondroma

Diseases related to Juxtacortical Chondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)

#	Related Disease	Score	Top Affiliating Genes
1	chondroma	30.8	CTNNB1 HMGA2 PTH1R
2	multiple enchondromatosis, maffucci type	10.6	EXT1 PTH1R
3	periostitis	10.3
4	atypical lipomatous tumor	10.3	FUS HMGA2
5	kidney fibrosarcoma	10.3	EWSR1 HMGA2
6	clear cell chondrosarcoma	10.3	PTH1R PTHLH
7	tooth ankylosis	10.3	PTH1R PTHLH
8	lipomatosis, multiple	10.3	FUS HMGA2
9	hypercalcemia, infantile, 1	10.2	PTH1R PTHLH
10	extraosseous chondrosarcoma	10.2	EWSR1 FUS
11	pyle disease	10.2	PTH1R PTHLH
12	chondroblastoma	10.2	PTH1R PTHLH
13	pseudohypoparathyroidism, type ib	10.2	PTH1R PTHLH
14	extraskeletal ewing sarcoma	10.2	EWSR1 FUS
15	metaphyseal chondrodysplasia, jansen type	10.2	PTH1R PTHLH
16	angiomyoma	10.1	HMGA2 PTHLH
17	chondromyxoid fibroma	10.1	PTH1R PTHLH
18	ideomotor apraxia	10.1	EWSR1 FUS
19	gastrointestinal system benign neoplasm	10.1	CTNNB1 HMGA2
20	osteochondroma	10.0	EXT1 PTHLH
21	clear cell adenoma	10.0	CTNNB1 PTHLH
22	skeletal dysplasias	10.0	PTH1R PTHLH
23	chondrosarcoma, extraskeletal myxoid	10.0	EWSR1 FUS
24	pseudohypoparathyroidism	10.0	PTH1R PTHLH
25	atypical teratoid rhabdoid tumor	9.9	CTNNB1 HMGA2
26	enchondromatosis, multiple, ollier type	9.9	EXT1 PTH1R PTHLH
27	connective tissue cancer	9.8	EWSR1 EXT1 FUS
28	bone disease	9.8	EXT1 PTH1R PTHLH
29	clear cell sarcoma	9.8	EWSR1 FUS
30	myxoid liposarcoma	9.8	EWSR1 FUS HMGA2
31	liposarcoma	9.8	EWSR1 FUS HMGA2
32	soft tissue sarcoma	9.7	EWSR1 TERT
33	fibrous histiocytoma	9.7	EWSR1 FUS
34	cystitis cystica	9.6	CTNNB1 TERT
35	periosteal chondrosarcoma	9.6	CTNNB1 EXT1 PTHLH
36	chondrosarcoma	9.6	EWSR1 EXT1 PTHLH
37	cell type benign neoplasm	9.5	CTNNB1 HMGA2

Graphical network of the top 20 diseases related to Juxtacortical Chondroma:

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Symptoms & Phenotypes for Juxtacortical Chondroma

UMLS symptoms related to Juxtacortical Chondroma:

pain

MGI Mouse Phenotypes related to Juxtacortical Chondroma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.85	PTH1R PTHLH CTNNB1 EXT1 TERT MIB1
2	craniofacial	MP:0005382	9.8	MIB1 PTH1R PTHLH CTNNB1 EXT1
3	endocrine/exocrine gland	MP:0005379	9.8	MIB1 PTH1R PTHLH CTNNB1 RBP1 TERT
4	growth/size/body region	MP:0005378	9.8	MIB1 PTH1R PTHLH CTNNB1 RBP1 EXT1
5	limbs/digits/tail	MP:0005371	9.55	MIB1 PTH1R PTHLH CTNNB1 EXT1
6	nervous system	MP:0003631	9.5	MIB1 PTH1R PTHLH CTNNB1 RBP1 EXT1
7	skeleton	MP:0005390	9.1	MIB1 PTH1R PTHLH CTNNB1 TERT EXT1

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Drugs & Therapeutics for Juxtacortical Chondroma

Search Clinical Trials , NIH Clinical Center for Juxtacortical Chondroma

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Genetic Tests for Juxtacortical Chondroma

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Anatomical Context for Juxtacortical Chondroma

MalaCards organs/tissues related to Juxtacortical Chondroma:

⁴¹

Bone, Cortex

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Publications for Juxtacortical Chondroma

Articles related to Juxtacortical Chondroma:

(show all 12)

#	Title	Authors	Year
1	Imaging features of juxtacortical chondroma in children. ( 23955368 )	Miller S.F.	2014
2	Juxtacortical chondroma of the sacrum. ( 18843465 )	Akiyama T....Kawano H.	2008
3	First occurrence of periosteal chondroma (juxtacortical chondroma) in Uromastyxmaliensis (Reptilia: Sauria: Agamidae). ( 17867460 )	GA!l J....Farkas B.	2007
4	Juxtacortical chondroma of the hand: treatment by resection of the tumour and the adjacent bone cortex. ( 15935532 )	Takada A....Shimamura T.	2005
5	Musculoskeletal case of the day. Periosteal (juxtacortical) chondroma. ( 7785598 )	Nguyen T.P....Burk D.L.	1995
6	Phalangeal periosteal (juxtacortical)chondroma of the foot. ( 1430837 )	Wu K.K.	1992
7	Case report 196: juxtacortical chondroma of C2. ( 6954647 )	Calderone A....Schiller A.L.	1982
8	Juxtacortical chondroma of the hyoid bone. Report of a case. ( 6058416 )	Grayson A....Bain M.	1967
9	Juxtacortical chondroma. A case report. ( 5837642 )	Cary G.R.	1965
10	Periosteal chondroma (juxtacortical chondroma). ( 5889127 )	MARMOR L.	1964
11	Juxtacortical chondroma. ( 13499868 )	Meyer R.	1958
12	Juxtacortical chondroma. ( 13374443 )	Jaffe H.L.	1956

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Genes for Juxtacortical Chondroma

Genes related to Juxtacortical Chondroma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIB1	Mindbomb E3 Ubiquitin Protein Ligase 1	Protein Coding	16.75	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PTH1R	Parathyroid Hormone 1 Receptor	Protein Coding	16.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	RBP1	Retinol Binding Protein 1	Protein Coding	15.53	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	EXT1	Exostosin Glycosyltransferase 1	Protein Coding	15.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	14.49	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	FUS	FUS RNA Binding Protein	Protein Coding	14.42	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	EWSR1	EWS RNA Binding Protein 1	Protein Coding	14.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	14.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	TERT	Telomerase Reverse Transcriptase	Protein Coding	13.97	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CTNNB1	Catenin Beta 1	Protein Coding	13.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Juxtacortical Chondroma

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Expression for Juxtacortical Chondroma

Search GEO for disease gene expression data for Juxtacortical Chondroma.

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Pathways for Juxtacortical Chondroma

Pathways related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Chromatin Regulation / Acetylation ⁴	11.84	EWSR1 FUS HMGA2
2	Mesodermal Commitment Pathway ¹ Show member pathways Endoderm Differentiation ¹	11.41	CTNNB1 EXT1 HMGA2 PTHLH
3	Transcriptional misregulation in cancer ³⁷	11.4	EWSR1 FUS HMGA2
4	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	10.75	PTH1R PTHLH

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GO Terms for Juxtacortical Chondroma

Cellular components related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-DNA complex	GO:0032993	8.62	CTNNB1 HMGA2

Biological processes related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	beta-catenin-TCF complex assembly	GO:1904837	9.49	CTNNB1 TERT
2	chondrocyte differentiation	GO:0002062	9.48	HMGA2 PTH1R
3	epithelial to mesenchymal transition	GO:0001837	9.46	CTNNB1 HMGA2
4	cell maturation	GO:0048469	9.43	CTNNB1 PTH1R
5	bone mineralization	GO:0030282	9.4	PTH1R PTHLH
6	bone resorption	GO:0045453	9.37	CTNNB1 PTH1R
7	negative regulation of cellular senescence	GO:2000773	9.32	HMGA2 TERT
8	osteoblast development	GO:0002076	9.26	PTH1R PTHLH
9	negative regulation of chondrocyte differentiation	GO:0032331	9.16	CTNNB1 PTHLH
10	positive regulation of stem cell proliferation	GO:2000648	8.96	HMGA2 TERT
11	skeletal system development	GO:0001501	8.92	CTNNB1 EXT1 PTH1R PTHLH

Molecular functions related to Juxtacortical Chondroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	SMAD binding	GO:0046332	8.96	CTNNB1 HMGA2
2	estrogen receptor binding	GO:0030331	8.62	CTNNB1 FUS

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Sources for Juxtacortical Chondroma

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