MCID: JXT003
MIFTS: 35

Juxtacortical Osteosarcoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Juxtacortical Osteosarcoma

MalaCards integrated aliases for Juxtacortical Osteosarcoma:

Name: Juxtacortical Osteosarcoma 12 15
Parosteal Osteosarcoma 12 73
Parosteal Osteogenic Sarcoma 12
Osteosarcoma, Juxtacortical 44

Classifications:



External Ids:

Disease Ontology 12 DOID:3373
MeSH 44 D018217
NCIt 50 C8969
UMLS 73 C0206642

Summaries for Juxtacortical Osteosarcoma

MalaCards based summary : Juxtacortical Osteosarcoma, also known as parosteal osteosarcoma, is related to periosteal osteogenic sarcoma and childhood parosteal osteogenic sarcoma. An important gene associated with Juxtacortical Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Apoptosis Modulation and Signaling. Affiliated tissues include bone, and related phenotypes are Increased cell death HMECs cells and Reduced mammosphere formation

Related Diseases for Juxtacortical Osteosarcoma

Diseases related to Juxtacortical Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 periosteal osteogenic sarcoma 30.4 CDK4 FOS IGF2 MDM2 SATB2
2 childhood parosteal osteogenic sarcoma 12.3
3 bizzare parosteal osteochondromatous proliferation 11.2
4 ring chromosome 7 10.8 CDK4 MDM2
5 undifferentiated embryonal sarcoma of the liver 10.8 CDK4 MDM2
6 infiltrating angiolipoma 10.8 CDK4 MDM2
7 spindle cell lipoma 10.8 CDK4 MDM2
8 extraosseous osteosarcoma 10.7 CDK4 MDM2
9 inflammatory mfh 10.7 CDK4 MDM2
10 lipoblastoma 10.7 CDK4 MDM2
11 conventional central osteosarcoma 10.7 MDM2 SATB2
12 mixed liposarcoma 10.7 CDK4 MDM2
13 ischemic fasciitis 10.7 CDK4 MDM2
14 atypical lipomatous tumor 10.6 CDK4 MDM2
15 spindle cell liposarcoma 10.6 CDK4 MDM2
16 well-differentiated liposarcoma 10.6 CDK4 MDM2
17 chondroid lipoma 10.6 CDK4 MDM2
18 dedifferentiated liposarcoma 10.5 CDK4 MDM2
19 connective tissue benign neoplasm 10.4 GNAS MDM2
20 lymph node cancer 10.4 FOS PLAUR
21 malignant fibrous histiocytoma of bone 10.4 CDK4 FOS MDM2
22 ossifying fibroma 10.3 GNAS MDM2
23 infiltrating lipoma 10.2 CDK4 MDM2
24 osteogenic sarcoma 10.2
25 sarcoma 10.2
26 bone osteosarcoma 10.2 CDK4 EMILIN1 MDM2 SATB2
27 periosteal chondrosarcoma 10.2 CDK4 MDM2 PTHLH
28 small cell sarcoma 10.1 CDK4 HSP90AA1 MDM2
29 adamantinoma of long bones 10.1 CDK4 MDM2 PLAUR
30 enthesopathy 10.0
31 leiomyosarcoma 9.8 CDK4 IGF2 MDM2
32 angiomatous meningioma 9.5 PLAUR WDFY2
33 prostate cancer 7.5 CDK4 CLU HSP90AA1 IGF2 MDM2 PLAUR
34 colorectal cancer 7.3 CDK4 CTSB FOS GNAS HSP90AA1 IGF2
35 peripheral osteosarcoma 5.3 CDK4 CLU CTSB EMILIN1 FABP3 FOS

Graphical network of the top 20 diseases related to Juxtacortical Osteosarcoma:



Diseases related to Juxtacortical Osteosarcoma

Symptoms & Phenotypes for Juxtacortical Osteosarcoma

GenomeRNAi Phenotypes related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.35 CLU CTSB FABP3 MDM2 PLAUR
2 Reduced mammosphere formation GR00396-S 9.17 MDM2 PLAUR CDK4 FABP3 GNAS HSP90AA1

MGI Mouse Phenotypes related to Juxtacortical Osteosarcoma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.37 CDK4 CLU CTSB FABP3 FOS GNAS
2 cellular MP:0005384 10.35 GNAS HSP90AA1 IGF2 MDM2 PLAUR POSTN
3 cardiovascular system MP:0005385 10.32 CDK4 CLU EMILIN1 FABP3 GNAS IGF2
4 homeostasis/metabolism MP:0005376 10.29 PLAUR POSTN PTHLH CDK4 CLU CTSB
5 growth/size/body region MP:0005378 10.28 CDK4 CTSB FOS GNAS HSP90AA1 IGF2
6 endocrine/exocrine gland MP:0005379 10.25 CDK4 CTSB FOS GNAS HSP90AA1 IGF2
7 immune system MP:0005387 10.24 CDK4 CLU CTSB FOS GNAS HSP90AA1
8 hematopoietic system MP:0005397 10.18 CDK4 EMILIN1 FOS GNAS IGF2 MDM2
9 craniofacial MP:0005382 10.17 FOS GNAS HSP90AA1 SATB2 IGF2 MDM2
10 mortality/aging MP:0010768 10.14 CDK4 CTSB FABP3 FOS GNAS HSP90AA1
11 integument MP:0010771 10.08 MDM2 PTHLH CTSB EMILIN1 FOS GNAS
12 limbs/digits/tail MP:0005371 10.06 FOS GNAS HSP90AA1 IGF2 MDM2 POSTN
13 digestive/alimentary MP:0005381 10.03 PTHLH SATB2 CDK4 CTSB IGF2 MDM2
14 muscle MP:0005369 9.97 CDK4 CLU FABP3 GNAS IGF2 MDM2
15 nervous system MP:0003631 9.96 CDK4 CLU CTSB FOS GNAS IGF2
16 liver/biliary system MP:0005370 9.91 CDK4 FABP3 GNAS IGF2 MDM2 PLAUR
17 neoplasm MP:0002006 9.8 CDK4 CTSB FOS GNAS MDM2 POSTN
18 renal/urinary system MP:0005367 9.76 CDK4 CLU CTSB GNAS IGF2 MDM2
19 reproductive system MP:0005389 9.5 CDK4 FOS HSP90AA1 IGF2 MDM2 POSTN
20 skeleton MP:0005390 9.23 POSTN PTHLH SATB2 FOS GNAS HSP90AA1

Drugs & Therapeutics for Juxtacortical Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Juxtacortical Osteosarcoma

Cochrane evidence based reviews: osteosarcoma, juxtacortical

Genetic Tests for Juxtacortical Osteosarcoma

Anatomical Context for Juxtacortical Osteosarcoma

MalaCards organs/tissues related to Juxtacortical Osteosarcoma:

41
Bone

Publications for Juxtacortical Osteosarcoma

Articles related to Juxtacortical Osteosarcoma:

(show all 14)
# Title Authors Year
1
Juxtacortical osteosarcoma of the mandible: Challenges in diagnosis and management. ( 26668470 )
2015
2
Juxtacortical osteosarcoma of mandible. ( 23483235 )
2011
3
An unusual case of juxtacortical osteosarcoma presenting on Tc-99m MDP bone scan with central photopenia. ( 14734911 )
2004
4
Juxtacortical osteosarcoma. A distinct malignant bone neoplasm. ( 11080792 )
2000
5
Clinical outcome of 38 patients with juxtacortical osteosarcoma. ( 10810479 )
2000
6
"Tumoral" enthesopathy: a juxtacortical osteosarcoma simulation. ( 1765994 )
1991
7
Juxtacortical osteosarcoma of the jaws. ( 2186801 )
1990
8
Juxtacortical osteosarcoma: a radiologic and histologic spectrum. ( 3860961 )
1985
9
Juxtacortical osteosarcoma of mandible: review of literature and report of case. ( 6940961 )
1981
10
Parosteal (juxtacortical) osteosarcoma. A clinical and histopathological study of 11 cases and a review of the literature. ( 6927979 )
1980
11
Parosteal (juxtacortical) osteosarcoma of the distal femur. ( 6938939 )
1980
12
Unusual spread of juxtacortical osteosarcoma. ( 6928013 )
1980
13
Juxtacortical osteosarcoma. Diagnosis, differential diagnosis, treatment, and an analysis of eighty cases. ( 5228781 )
1967
14
Early juxtacortical osteosarcoma (parosteal osteoma). ( 13610963 )
1958

Variations for Juxtacortical Osteosarcoma

Expression for Juxtacortical Osteosarcoma

Search GEO for disease gene expression data for Juxtacortical Osteosarcoma.

Pathways for Juxtacortical Osteosarcoma

GO Terms for Juxtacortical Osteosarcoma

Cellular components related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 CLU CTSB EMILIN1 FABP3 GNAS HSP90AA1
2 extracellular space GO:0005615 9.7 CLU CTSB EMILIN1 FABP3 IGF2 POSTN
3 perinuclear region of cytoplasm GO:0048471 9.35 CDK4 CLU CTSB GNAS HSP90AA1
4 extracellular region GO:0005576 9.28 CLU CTSB EMILIN1 GNAS HSP90AA1 IGF2

Biological processes related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to toxic substance GO:0009636 9.58 CDK4 FOS MDM2
2 positive regulation of protein phosphorylation GO:0001934 9.56 HSP90AA1 IGF2 PLAUR WDFY2
3 female pregnancy GO:0007565 9.54 FOS GNAS PTHLH
4 DNA methylation GO:0006306 9.52 FOS GNAS
5 negative regulation of cell cycle arrest GO:0071157 9.51 CDK4 MDM2
6 positive regulation of osteoclast differentiation GO:0045672 9.49 FOS GNAS
7 chaperone-mediated protein complex assembly GO:0051131 9.48 CLU HSP90AA1
8 osteoblast development GO:0002076 9.46 PTHLH SATB2
9 skeletal system development GO:0001501 9.46 GNAS IGF2 POSTN PTHLH
10 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.43 GNAS PTHLH
11 response to drug GO:0042493 9.35 CDK4 FABP3 FOS GNAS MDM2
12 positive regulation of tau-protein kinase activity GO:1902949 9.32 CLU HSP90AA1
13 regulation of gene expression GO:0010468 9.02 CDK4 IGF2 MDM2 PTHLH SATB2

Molecular functions related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 CDK4 CLU CTSB EMILIN1 FABP3 FOS
2 insulin-like growth factor receptor binding GO:0005159 9.16 GNAS IGF2
3 tau protein binding GO:0048156 8.96 CLU HSP90AA1

Sources for Juxtacortical Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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