MCID: JXT003
MIFTS: 40

Juxtacortical Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Juxtacortical Osteosarcoma

MalaCards integrated aliases for Juxtacortical Osteosarcoma:

Name: Juxtacortical Osteosarcoma 12 15
Parosteal Osteosarcoma 12 73
Parosteal Osteogenic Sarcoma 12
Osteosarcoma, Juxtacortical 44

Classifications:



External Ids:

Disease Ontology 12 DOID:3373
MeSH 44 D018217
NCIt 50 C8969
SNOMED-CT 68 91242000
UMLS 73 C0206642

Summaries for Juxtacortical Osteosarcoma

MalaCards based summary : Juxtacortical Osteosarcoma, also known as parosteal osteosarcoma, is related to periosteal osteogenic sarcoma and bone osteosarcoma. An important gene associated with Juxtacortical Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Apoptosis Modulation and Signaling. Affiliated tissues include bone, liver and lymph node, and related phenotypes are Increased cell death HMECs cells and Reduced mammosphere formation

Related Diseases for Juxtacortical Osteosarcoma

Diseases related to Juxtacortical Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 periosteal osteogenic sarcoma 31.7 CDK4 FOS IGF2 MDM2 SATB2
2 bone osteosarcoma 30.2 CDK4 EMILIN1 MDM2 SATB2
3 childhood parosteal osteogenic sarcoma 12.4
4 bizzare parosteal osteochondromatous proliferation 11.4
5 osteogenic sarcoma 10.7
6 sarcoma 10.7
7 osteochondroma 10.3
8 extraosseous osteosarcoma 10.3
9 ring chromosome 7 10.2 CDK4 MDM2
10 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2
11 infiltrating angiolipoma 10.2 CDK4 MDM2
12 spindle cell lipoma 10.2 CDK4 MDM2
13 cellular myxoid liposarcoma 10.2 CDK4 MDM2
14 lipoblastoma 10.2 CDK4 MDM2
15 conventional central osteosarcoma 10.2 MDM2 SATB2
16 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.2 GNAS SATB2
17 atypical lipomatous tumor 10.2 CDK4 MDM2
18 myositis 10.2
19 fibrous dysplasia 10.2
20 myositis ossificans 10.2
21 telangiectatic osteogenic sarcoma 10.2
22 mixed liposarcoma 10.2 CDK4 MDM2
23 chondroid lipoma 10.2 CDK4 MDM2
24 spindle cell liposarcoma 10.2 CDK4 MDM2
25 ischemic fasciitis 10.1 CDK4 MDM2
26 malignant fibrous histiocytoma of bone 10.1 CDK4 FOS MDM2
27 lymph node cancer 10.1 FOS PLAUR
28 periosteal chondrosarcoma 10.1 CDK4 MDM2 PTHLH
29 enthesopathy 10.1
30 ossifying fibroma 10.1 GNAS MDM2
31 small cell sarcoma 10.1 CDK4 HSP90AA1 MDM2
32 nasopharyngeal carcinoma 10.0
33 giant cell tumor 10.0
34 ossifying fibromyxoid tumor 10.0
35 brachydactyly, type e2 10.0 GNAS PTHLH
36 leiomyosarcoma 10.0 CDK4 IGF2 MDM2
37 dedifferentiated liposarcoma 10.0 CDK4 MDM2
38 inflammatory mfh 10.0 CDK4 FRS2 MDM2
39 well-differentiated liposarcoma 9.9 CDK4 FRS2 MDM2
40 large intestine cancer 9.8 CDK4 GNAS IGF2 MDM2 PLAUR
41 prostate cancer 9.4 CDK4 CLU HSP90AA1 IGF2 MDM2 PLAUR
42 peripheral osteosarcoma 8.6 CDK4 CLU CTSB EMILIN1 FABP3 FOS

Graphical network of the top 20 diseases related to Juxtacortical Osteosarcoma:



Diseases related to Juxtacortical Osteosarcoma

Symptoms & Phenotypes for Juxtacortical Osteosarcoma

GenomeRNAi Phenotypes related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.35 CLU CTSB FABP3 MDM2 PLAUR
2 Reduced mammosphere formation GR00396-S 9.23 CDK4 FABP3 FRS2 GNAS HSP90AA1 IGF2

MGI Mouse Phenotypes related to Juxtacortical Osteosarcoma:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.37 CDK4 CTSB FABP3 FOS FRS2 GNAS
2 behavior/neurological MP:0005386 10.35 CDK4 CLU CTSB FABP3 FOS GNAS
3 cardiovascular system MP:0005385 10.35 CDK4 CLU EMILIN1 FABP3 FRS2 GNAS
4 growth/size/body region MP:0005378 10.3 CDK4 CTSB FOS FRS2 GNAS HSP90AA1
5 homeostasis/metabolism MP:0005376 10.27 CDK4 CLU CTSB EMILIN1 FABP3 FOS
6 endocrine/exocrine gland MP:0005379 10.24 CDK4 CTSB FOS GNAS HSP90AA1 IGF2
7 immune system MP:0005387 10.22 CDK4 CLU CTSB FOS GNAS HSP90AA1
8 craniofacial MP:0005382 10.2 FOS FRS2 GNAS HSP90AA1 IGF2 MDM2
9 hematopoietic system MP:0005397 10.16 CDK4 EMILIN1 FOS GNAS IGF2 MDM2
10 mortality/aging MP:0010768 10.15 CDK4 CTSB FABP3 FOS FRS2 GNAS
11 limbs/digits/tail MP:0005371 10.09 FOS FRS2 GNAS HSP90AA1 IGF2 MDM2
12 integument MP:0010771 10.06 CDK4 CTSB EMILIN1 FOS GNAS IGF2
13 liver/biliary system MP:0005370 9.95 CDK4 FABP3 GNAS IGF2 MDM2 PLAUR
14 muscle MP:0005369 9.92 CDK4 CLU FABP3 GNAS IGF2 MDM2
15 nervous system MP:0003631 9.9 CDK4 CLU CTSB FOS FRS2 GNAS
16 neoplasm MP:0002006 9.8 CDK4 CTSB FOS GNAS MDM2 POSTN
17 renal/urinary system MP:0005367 9.61 CDK4 CLU CTSB FRS2 GNAS IGF2
18 skeleton MP:0005390 9.28 FOS FRS2 GNAS HSP90AA1 IGF2 MDM2

Drugs & Therapeutics for Juxtacortical Osteosarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 an Istitution Experience on Parosteal OsTeosarcoma Recruiting NCT03768076

Search NIH Clinical Center for Juxtacortical Osteosarcoma

Cochrane evidence based reviews: osteosarcoma, juxtacortical

Genetic Tests for Juxtacortical Osteosarcoma

Anatomical Context for Juxtacortical Osteosarcoma

MalaCards organs/tissues related to Juxtacortical Osteosarcoma:

41
Bone, Liver, Lymph Node, Prostate

Publications for Juxtacortical Osteosarcoma

Articles related to Juxtacortical Osteosarcoma:

(show top 50) (show all 126)
# Title Authors Year
1
Parosteal osteosarcoma with focal fatty metaplasia: A case report. ( 30425774 )
2019
2
Can imaging distinguish between low-grade and dedifferentiated parosteal osteosarcoma? ( 30190236 )
2018
3
Zygomatic Arch Parosteal Osteosarcoma in Dogs and a Cat. ( 30244660 )
2018
4
Dedifferentiated parosteal osteosarcoma of the maxilla: a case report and review of the literature. ( 30115116 )
2018
5
Analysis of miR-148b expression differences in stage-I and II parosteal osteosarcoma. ( 29963175 )
2018
6
Dedifferentiated parosteal osteosarcoma of the calvaria. ( 29686561 )
2018
7
Parosteal osteosarcoma of mandible: A rare case report. ( 29516945 )
2018
8
On the importance of considering disease subtypes: Earliest detection of a parosteal osteosarcoma? Differential diagnosis of an osteosarcoma in an Anglo-Saxon female. ( 29776880 )
2018
9
Juxtacortical osteosarcoma of the mandible: Challenges in diagnosis and management. ( 26668470 )
2015
10
Comments on Carter et al's "activating GNAS mutations in parosteal osteosarcoma". ( 25970689 )
2015
11
Custom-made intercalary endoprosthetic reconstruction for a parosteal osteosarcoma of the femoral diaphysis: A case report. ( 26722326 )
2015
12
Parosteal osteosarcoma. ( 24786129 )
2014
13
Cortical bone remodeling in parosteal osteosarcoma mimicking medullary involvement: a case with the difficulty in pre-surgical staging. ( 24965686 )
2014
14
Parosteal osteosarcoma of the 2nd metatarsal. ( 24471145 )
2013
15
12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. ( 22749040 )
2012
16
Primary parosteal osteosarcoma of the rib. ( 22514259 )
2012
17
Juxtacortical osteosarcoma of mandible. ( 23483235 )
2011
18
Treatment and outcome of parosteal osteosarcoma: biological versus endoprosthetic reconstruction. ( 21240982 )
2011
19
Outcome of re-excision for intralesionally treated parosteal osteosarcoma. ( 21337555 )
2011
20
Primary dedifferentiated parosteal osteosarcoma in a 21-year-old man. ( 22022683 )
2011
21
Local recurrence of a parosteal osteosarcoma 21 years after incomplete resection. ( 22059909 )
2011
22
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. ( 19826810 )
2010
23
Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. ( 19271217 )
2009
24
Femoral parosteal osteosarcoma 18 years after its discovery: a case report. ( 19501035 )
2009
25
Parosteal osteosarcoma. ( 19507652 )
2009
26
Abdominal metastasis of a parosteal osteosarcoma of the femur: an unusual cause of large-bowel obstruction. ( 19994810 )
2009
27
Parosteal osteosarcoma of the orbit. ( 18520844 )
2008
28
MRI findings in parosteal osteosarcoma: correlation with histopathology. ( 18814136 )
2008
29
Resection of parosteal osteosarcoma of the distal part of the femur: an original reconstruction technique with cement and plate. ( 18949052 )
2008
30
Parosteal osteosarcoma: case report and review of the literature. ( 17615569 )
2008
31
Clinical outcome of parosteal osteosarcoma. ( 18050289 )
2008
32
Late recurrence in primary region of parosteal osteosarcoma: a case report. ( 18231959 )
2008
33
Dedifferentiated parosteal osteosarcoma with well-differentiated metastases. ( 16518652 )
2006
34
Oncologic outcome of parosteal osteosarcoma. ( 16622746 )
2006
35
Parosteal osteosarcoma of the thumb metacarpal: a case report. ( 16789464 )
2006
36
Unusual benign bone lesion simulating parosteal osteosarcoma. ( 17013744 )
2006
37
Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute. ( 15852358 )
2005
38
An unusual case of juxtacortical osteosarcoma presenting on Tc-99m MDP bone scan with central photopenia. ( 14734911 )
2004
39
Parosteal osteosarcoma of the mastoid bone following radiotherapy for nasopharyngeal carcinoma. ( 15366412 )
2004
40
Local recurrence of parosteal osteosarcoma adjacent to a prosthesis after 20 years: a case report. ( 15621920 )
2004
41
Parosteal osteosarcoma of the distal ulna. A rare tumour at a rare location: a case report. ( 12822246 )
2003
42
Extraskeletal osteosarcoma histologically mimicking parosteal osteosarcoma. ( 12167110 )
2002
43
Imaging recurrent parosteal osteosarcoma. ( 11288853 )
2001
44
The role of imaging modalities in the diagnosis of primary dedifferentiated parosteal osteosarcoma. ( 11484126 )
2001
45
Parosteal osteosarcoma of the humerus. ( 11725572 )
2001
46
Parosteal osteosarcoma of the skull. ( 11787402 )
2001
47
Juxtacortical osteosarcoma. A distinct malignant bone neoplasm. ( 11080792 )
2000
48
Clinical outcome of 38 patients with juxtacortical osteosarcoma. ( 10810479 )
2000
49
Parosteal osteosarcoma of the posterior aspect of the distal part of the femur. Oncological and functional results following a new resection technique. ( 10954096 )
2000
50
Parosteal osteosarcoma of the ring finger metacarpal in a semi-professional pianist. ( 10961564 )
2000

Variations for Juxtacortical Osteosarcoma

Expression for Juxtacortical Osteosarcoma

Search GEO for disease gene expression data for Juxtacortical Osteosarcoma.

Pathways for Juxtacortical Osteosarcoma

Pathways related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 CDK4 GNAS HSP90AA1 IGF2 MDM2
2
Show member pathways
12.42 CTSB FOS HSP90AA1 IGF2 MDM2
3 12.16 CDK4 FOS GNAS PLAUR
4
Show member pathways
12.09 FOS HSP90AA1 IGF2 MDM2
5 11.86 FRS2 IGF2 MDM2 PLAUR
6 11.82 CDK4 FOS GNAS HSP90AA1 IGF2 MDM2
7
Show member pathways
11.75 CDK4 FOS GNAS PLAUR
8 11.73 CDK4 IGF2 MDM2
9 11.7 FOS GNAS PTHLH
10 11.62 FOS GNAS HSP90AA1
11 11.52 FOS HSP90AA1 MDM2
12 11.38 CDK4 FOS GNAS
13 11 FOS FRS2 PLAUR
14 10.91 FOS GNAS
15 10.72 FOS GNAS PTHLH

GO Terms for Juxtacortical Osteosarcoma

Cellular components related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CLU CTSB EMILIN1 FABP3 IGF2 POSTN
2 perinuclear region of cytoplasm GO:0048471 9.55 CDK4 CLU CTSB GNAS HSP90AA1
3 extracellular region GO:0005576 9.28 CLU CTSB EMILIN1 GNAS HSP90AA1 IGF2
4 collagen-containing extracellular matrix GO:0062023 9.26 CLU CTSB EMILIN1 POSTN

Biological processes related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.62 CDK4 MDM2 PTHLH SATB2
2 response to toxic substance GO:0009636 9.58 CDK4 FOS MDM2
3 female pregnancy GO:0007565 9.54 FOS GNAS PTHLH
4 DNA methylation GO:0006306 9.51 FOS GNAS
5 negative regulation of cell cycle arrest GO:0071157 9.49 CDK4 MDM2
6 positive regulation of osteoclast differentiation GO:0045672 9.48 FOS GNAS
7 osteoblast development GO:0002076 9.46 PTHLH SATB2
8 positive regulation of protein phosphorylation GO:0001934 9.46 HSP90AA1 IGF2 PLAUR WDFY2
9 chaperone-mediated protein complex assembly GO:0051131 9.43 CLU HSP90AA1
10 positive regulation of tau-protein kinase activity GO:1902949 9.26 CLU HSP90AA1
11 skeletal system development GO:0001501 9.26 GNAS IGF2 POSTN PTHLH
12 response to drug GO:0042493 9.02 CDK4 FABP3 FOS GNAS MDM2

Molecular functions related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 CDK4 CLU CTSB EMILIN1 FABP3 FOS
2 tau protein binding GO:0048156 9.16 CLU HSP90AA1
3 insulin-like growth factor receptor binding GO:0005159 8.96 GNAS IGF2

Sources for Juxtacortical Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....