MCID: JXT003
MIFTS: 28

Juxtacortical Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Juxtacortical Osteosarcoma

MalaCards integrated aliases for Juxtacortical Osteosarcoma:

Name: Juxtacortical Osteosarcoma 12 15 17
Parosteal Osteosarcoma 12 70
Parosteal Osteogenic Sarcoma 12
Osteosarcoma, Juxtacortical 44

Classifications:



External Ids:

Disease Ontology 12 DOID:3373
MeSH 44 D018217
NCIt 50 C8969
SNOMED-CT 67 91242000
UMLS 70 C0206642

Summaries for Juxtacortical Osteosarcoma

MalaCards based summary : Juxtacortical Osteosarcoma, also known as parosteal osteosarcoma, is related to osteogenic sarcoma and telangiectatic osteogenic sarcoma. An important gene associated with Juxtacortical Osteosarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Integrated Cancer Pathway and DNA damage_ATM/ATR regulation of G1/S checkpoint. Related phenotypes are craniofacial and normal

Related Diseases for Juxtacortical Osteosarcoma

Diseases related to Juxtacortical Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 osteogenic sarcoma 30.8 RECQL4 MDM2 COPS3 CDK4
2 telangiectatic osteogenic sarcoma 30.7 MDM2 COPS3
3 ring chromosome 30.4 MDM2 CDK4
4 embryonal sarcoma 30.4 MDM2 CDK4
5 myositis ossificans 30.3 SATB2 MDM2 CDK4
6 malignant fibrous histiocytoma 30.2 RECQL4 MDM2 CDK4
7 extraosseous osteosarcoma 30.1 SATB2 MDM2 CDK4
8 well-differentiated liposarcoma 30.0 MDM2 CDK4
9 periosteal osteogenic sarcoma 29.9 SATB2 MDM2 GNAS
10 conventional central osteosarcoma 29.2 SNRNP25 SATB2 MDM2 COPS3 CDK4
11 bone osteosarcoma 28.1 SNRNP25 SATB2 RECQL4 MDM2 KCNMB4 GNAS
12 peripheral osteosarcoma 27.5 VGLL3 SNRNP25 SATB2 MDM2 KCNMB4 GNAS
13 childhood parosteal osteogenic sarcoma 11.3
14 bizarre parosteal osteochondromatous proliferation 11.2
15 sarcoma 10.6
16 spindle cell sarcoma 10.6
17 osteochondroma 10.4
18 myositis 10.3
19 ring chromosome 7 10.3 MDM2 CDK4
20 mediastinum liposarcoma 10.3 MDM2 CDK4
21 gastric liposarcoma 10.3 MDM2 CDK4
22 infiltrating lipoma 10.3 MDM2 CDK4
23 spindle cell liposarcoma 10.3 MDM2 CDK4
24 undifferentiated embryonal sarcoma of the liver 10.3 MDM2 CDK4
25 pediatric liposarcoma 10.3 MDM2 CDK4
26 diffuse lipomatosis 10.3 MDM2 CDK4
27 lipoblastoma 10.3 MDM2 CDK4
28 malignant inflammatory fibrous histiocytoma 10.3 MDM2 CDK4
29 liposarcoma of bone 10.3 MDM2 CDK4
30 pancreas sarcoma 10.3 MDM2 CDK4
31 paratesticular lipoma 10.3 MDM2 CDK4
32 lipoma of spermatic cord 10.3 MDM2 CDK4
33 adult liposarcoma 10.2 MDM2 CDK4
34 mixed liposarcoma 10.2 MDM2 CDK4
35 infiltrating angiolipoma 10.2 MDM2 CDK4
36 pleomorphic lipoma 10.2 MDM2 CDK4
37 retroperitoneal sarcoma 10.2 MDM2 CDK4
38 fibrous dysplasia 10.2
39 fibrosarcomatous osteosarcoma 10.2
40 parameningeal embryonal rhabdomyosarcoma 10.2 MDM2 CDK4
41 hereditary melanoma 10.2 MDM2 CDK4
42 spindle cell lipoma 10.2 MDM2 CDK4
43 cellular myxoid liposarcoma 10.2 MDM2 CDK4
44 ischemic fasciitis 10.2 MDM2 CDK4
45 retroperitoneum carcinoma 10.2 MDM2 CDK4
46 pleomorphic liposarcoma 10.1 MDM2 CDK4
47 liposarcoma 10.1
48 fibrous histiocytoma 10.1
49 primary bone cancer 10.1
50 mandibular cancer 10.1 MDM2 GNAS

Graphical network of the top 20 diseases related to Juxtacortical Osteosarcoma:



Diseases related to Juxtacortical Osteosarcoma

Symptoms & Phenotypes for Juxtacortical Osteosarcoma

MGI Mouse Phenotypes related to Juxtacortical Osteosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.35 CDK4 GNAS MDM2 RECQL4 SATB2
2 normal MP:0002873 9.1 ATP8A1 CDK4 GNAS KCNMB4 MDM2 VGLL3

Drugs & Therapeutics for Juxtacortical Osteosarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parosteal OsTeosarcoma: a Single Istitution Experience Unknown status NCT03768076

Search NIH Clinical Center for Juxtacortical Osteosarcoma

Cochrane evidence based reviews: osteosarcoma, juxtacortical

Genetic Tests for Juxtacortical Osteosarcoma

Anatomical Context for Juxtacortical Osteosarcoma

Publications for Juxtacortical Osteosarcoma

Articles related to Juxtacortical Osteosarcoma:

(show top 50) (show all 326)
# Title Authors PMID Year
1
Parosteal osteosarcoma with a manifestation of subperiosteal low-grade central osteosarcoma. 61
33704522 2021
2
Computer-assisted surgical planning of complex bone tumor resections improves negative margin outcomes in a sawbones model. 61
33725339 2021
3
Parosteal osteosarcoma of the mandible in a pediatric patient. 61
33579634 2021
4
The value of chest and skeletal staging in parosteal osteosarcoma: two-centre experience and literature review. 61
32705301 2021
5
Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report. 61
32564106 2021
6
Two cases of parosteal osteosarcoma with unusual histological and molecular features. 61
33272695 2020
7
Was it Ewing's? A Diagnostic and Therapeutic Dilemma. 61
33364700 2020
8
Rapidly growing Fibro-osseous pseudotumor of the digit: A case report. 61
32664136 2020
9
Parosteal Osteosarcoma of the Proximal Phalanx of a Finger. 61
31537402 2020
10
Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion) in Pediatric Phalanges. 61
32611484 2020
11
Low-grade Osteosarcomatous Dedifferentiation of an Atypical Lipomatous Tumor in a Pediatric Patient. 61
31739757 2020
12
[Parosteal low-grade osteosarcoma with focal differentiation]. 61
31919554 2020
13
[Osteoid-forming bone tumors : Morphology and current translational cell biology]. 61
32078700 2020
14
Inflammation and infiltration: can the radiologist draw a line? MRI versus CT to accurately assess medullary involvement in parosteal osteosarcoma. 61
32079463 2020
15
Parosteal Osteosarcoma: A Benign-Looking Tumour, Amenable to a Variety of Surgical Reconstruction. 61
32550023 2020
16
Nail Salon a Potential Source of a Rare Mycobacterium Fortuitum Infection In Proximal Tibia Megaprosthesis? A Case Report. 61
32566452 2020
17
Gene amplification and tumor grading in parosteal osteosarcoma. 61
31634336 2019
18
Parosteal osteosarcoma: a monocentric retrospective analysis of 195 patients. 61
31128127 2019
19
Zygomatic Arch Parosteal Osteosarcoma in Dogs and a Cat. 61
30244660 2019
20
Parosteal osteosarcoma with focal fatty metaplasia: A case report. 61
30425774 2019
21
Modular endoprosthetic implant for maximizing residual limb length: A case report. 61
30319024 2019
22
A rare rib lesion due to parosteal osteosarcoma: a case report. 61
30670083 2019
23
Parosteal osteosarcoma of the fibula in a middle-aged patient: A case report. 61
30633158 2019
24
Osteosarcoma in patients below 25 years of age: An observational study of incidence, metastasis, treatment and outcomes. 61
30405789 2018
25
Can imaging distinguish between low-grade and dedifferentiated parosteal osteosarcoma? 61
30190236 2018
26
Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis. 61
30001240 2018
27
Dedifferentiated parosteal osteosarcoma of the maxilla: a case report and review of the literature. 61
30115116 2018
28
Analysis of miR-148b expression differences in stage-I and II parosteal osteosarcoma. 61
29963175 2018
29
Unsintered Hydroxyapatite and Poly-L-Lactide Composite Screws/Plates for Stabilizing β-Tricalcium Phosphate Bone Implants. 61
29854351 2018
30
On the importance of considering disease subtypes: Earliest detection of a parosteal osteosarcoma? Differential diagnosis of an osteosarcoma in an Anglo-Saxon female. 61
29776880 2018
31
[Dedifferentiated diaphyseal juxtacortical osteosarcoma of ulna with metastasis to the lung]. 61
30521709 2018
32
Parosteal osteosarcoma of mandible: A rare case report. 61
29516945 2018
33
Dedifferentiated parosteal osteosarcoma of the calvaria. 61
29686561 2018
34
Long-Term Functional Outcomes of Distal Femoral Replacements Compared to Geographic Resections for Parosteal Osteosarcomas of the Distal Femur. 61
30104942 2018
35
Parosteal Osteosarcoma of the Distal Radius Mimicking an Osteochondroma-A Diagnostic Misadventure. 61
28917546 2017
36
The History of Bone Tumour Treatment and the State of the Art in Vienna. 61
29668473 2017
37
Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status. 61
28235629 2017
38
A Pediatric Case of Metastatic Conventional Parosteal Osteosarcoma Treated With Multidrug Chemotherapy. 61
27149276 2016
39
[Value of MDM2, CDK4 and SATB2 immunohistochemistry in histologic diagnosis of low-grade osteosarcoma]. 61
27256046 2016
40
Solitary synovial chondromatosis arising in the gluteus maximus bursa: computed tomography and magnetic resonance imaging findings. 61
26998347 2016
41
Bizarre parosteal osteochondromatous proliferation (Nora's lesion) affecting the distal end of the ulna: a case report. 61
26984018 2016
42
Surface osteosarcoma: Clinical features and therapeutic implications. 61
26730360 2015
43
The prognostic and therapeutic factors which influence the oncological outcome of parosteal osteosarcoma. 61
26637687 2015
44
Custom-made intercalary endoprosthetic reconstruction for a parosteal osteosarcoma of the femoral diaphysis: A case report. 61
26722326 2015
45
GNAS mutations are not detected in parosteal and low-grade central osteosarcomas. 61
26248895 2015
46
Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones. 61
26301184 2015
47
Comments on Carter et al's "activating GNAS mutations in parosteal osteosarcoma". 61
25970689 2015
48
[Subtotal Segment Resection, Augmenting Angle-Stable Plate Osteosynthesis and Allogenic Bone Graft as Treatment Option for Juxtacortical Osteosarcoma in the Knee Region]. 61
26114561 2015
49
Clinical outcome of low-grade central osteosarcoma and role of CDK4 and MDM2 immunohistochemistry as a diagnostic adjunct. 61
25740728 2015
50
Osteoma of long bone: an expanding spectrum of imaging findings. 61
25380570 2015

Variations for Juxtacortical Osteosarcoma

Expression for Juxtacortical Osteosarcoma

Search GEO for disease gene expression data for Juxtacortical Osteosarcoma.

Pathways for Juxtacortical Osteosarcoma

Pathways related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 MDM2 CDK4
2 10.6 MDM2 CDK4
3 10.13 MDM2 CDK4

GO Terms for Juxtacortical Osteosarcoma

Biological processes related to Juxtacortical Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 9.16 MDM2 CDK4
2 cellular response to organic substance GO:0071310 8.96 SATB2 MDM2
3 negative regulation of cell cycle arrest GO:0071157 8.62 MDM2 CDK4

Sources for Juxtacortical Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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